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This page shows you the latest news and research items in this category.

Ovarian cancer prediction: development of a scoring system for primary care.
CONCLUSION: This scoring system could potentially direct general practitioners to appropriate investigations for ovarian cancer on the basis of symptoms and save a substantial number of unnecessary ultrasound scans being requested. PMID: 23759087 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 17, 2013 Category: OBGYN Authors: Grewal K, Hamilton W, Sharp D Tags: BJOG Source Type: research

Blood test one day may detect oral cancer from oral sex
BETHESDA, Md., June 17 (UPI) -- A test may one day detect human papillomavirus to identify those of increased risk of HPV-related oral cancer as a result of oral sex, U.S. researchers say. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 17, 2013 Category: Consumer Health News Source Type: news

'Quiet epidemic' of UK male cancer
Action is needed to fight a "quiet epidemic" of oesophageal cancer, which is on the rise in the UK, particularly in men, say cancer experts. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - June 17, 2013 Category: Consumer Health News Source Type: news

Sarcopenia and physical function in overweight patients with advanced cancer.
Abstract Advanced cancer is associated with numerous metabolic abnormalities that may lead to significant body composition changes, particularly muscle loss or sarcopenia. Sarcopenia in cancer has been associated with poor clinical outcomes, including poor physical function. Accurate tools to assess body composition are expensive and not readily available in clinical settings. Unfortunately, little is known about the efficacy of affordable and portable techniques to assess functional status in patients with cancer. We investigated the prevalence of sarcopenia and its association with different portable and low-cost...
Source: Canadian Journal of Dietetic Practice and Research - June 17, 2013 Category: Nutrition Authors: Prado CM, Lieffers JR, Bowthorpe L, Baracos VE, Mourtzakis M, McCargar LJ Tags: Can J Diet Pract Res Source Type: research

Tumor Thrombus
A 48-year-old nonsmoking woman presented with acute epigastric pain after several months of nocturnal sweats. Computed tomography revealed a 9-cm right renal mass with venous tumor thrombus extending from the right renal vein to the right atrium, with no pulmonary embolism and no evidence of distant metastasis. Intraoperative transesophageal echocardiogram demonstrated an 8- × 4-cm echogenic mass (TT) recoiling into the right atrium in systole (A, Online Video 1) and prolapsing into the right ventricle (RV) in diastole (B), with an intact tricuspid valve (Online Video 2). The mass prolapsed into the right ventricular ou...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 17, 2013 Category: Cardiology Source Type: research

Observation of Prostate Cancer Safe, Saves $$$ (CME/CE)
(MedPage Today) -- Observation topped initial treatment for low-risk prostate cancer in terms of cost and effectiveness, according to a decision-analysis study. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - June 17, 2013 Category: Consumer Health News Source Type: news

J&J in $1 billion deal to bolster prostate-cancer focus
(Reuters) - Johnson & Johnson said it would pay up to $1 billion for Aragon Pharmaceuticals and its experimental drugs for prostate cancer, to bolster J&J's role in the field after it acquired another experimental prostate-cancer treatment four years ago that has become a leading brand. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Wait-and-see may be best for early prostate cancer
NEW YORK (Reuters Health) - Watching and routinely examining men with early, slow-growing prostate cancer is more effective and cheaper than sending them to surgery or radiation right away, according to a new study. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Blood tests could detect sexually-transmitted oral cancers
LONDON (Reuters) - Antibodies to a high-risk type of a virus that causes mouth and throat cancers when transmitted via oral sex can be detected in blood tests many years before onset of the disease, according to a World Health Organisation-led team of researchers. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

‘How to Be a Friend to a Friend Who’s Sick’ Can Be Harder Than It Sounds
Supporting friends in times of serious trouble, like during an illness, can be difficult. (Source: NYT Health)
Source: NYT Health - June 17, 2013 Category: Consumer Health News Authors: By CORNELIA DEAN Tags: Friendship Breast Cancer Medicine and Health Books and Literature Source Type: news

Books: ‘How to Be a Friend to a Friend Who’s Sick’ Can Be Harder Than It Sounds
Supporting friends in times of serious trouble, like during an illness, can be difficult. (Source: NYT Health)
Source: NYT Health - June 17, 2013 Category: Consumer Health News Authors: By CORNELIA DEAN Tags: Friendship Breast Cancer Medicine and Health Books and Literature Source Type: news

Bevacizumab Shows Activity in Rare Ovarian CancerBevacizumab Shows Activity in Rare Ovarian Cancer
Dr. Rachel Grisham describes favorable responses to bevacizumab treatment in recurrent and persistent low-grade serous and serous borderline ovarian cancer. Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

PARP Inhibitors Hold Promise in Pancreas CancerPARP Inhibitors Hold Promise in Pancreas Cancer
Dr. O'Reilly reviews data on therapies in pancreatic cancer presented at ASCO 2013, including early findings suggesting that PARP inhibitors are active in this disease. Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Supreme Court Says No to Patents on Human Genes
On 13 June 2013 the United States Supreme Court ruled that human genes cannot be patented. The unanimous decision stated that isolating specific genes was not worthy of a patent. The case considered by the high court dealt with patents held by Myriad Genetics, Inc. for two genes (BRCA1 and BRCA2) that have been linked to breast and ovarian cancer. The company uses the genes to test patients for their risk of developing cancer. “Myriad did not create anything,” wrote Justice Clarence Thomas on behalf of the court. “To be sure, it found an important and useful gene, but separating that gene from its surro...
Source: Public Policy Reports - June 17, 2013 Category: Biology Authors: AIBS Source Type: news

J&J, in new $1 billion deal, bolsters prostate-cancer role
(Reuters) - Johnson & Johnson said it would pay up to $1 billion for Aragon Pharmaceuticals and its experimental drugs for prostate cancer, bolstering J&J's role in the field after it acquired another experimental prostate-cancer treatment four years ago that has become a leading brand. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Whole exome sequencing of adenoid cystic carcinoma
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, combined, implicate chromatin deregulation in half of cases. Further, mutations were identified in known cancer genes, including PIK3C...
Source: Journal of Clinical Investigation - June 17, 2013 Category: Biomedical Science Authors: Philip J. Stephens, Helen R. Davies, Yoshitsugu Mitani, Peter Van Loo, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Angela Cheverton, Graham R. Bignell, Adam P. Butler, John Gamble, Stephen Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Source Type: research

CD4+ follicular helper T cell infiltration predicts breast cancer survival
CD4+ T cells are critical regulators of immune responses, but their functional role in human breast cancer is relatively unknown. The goal of this study was to produce an image of CD4+ T cells infiltrating breast tumors using limited ex vivo manipulation to better understand the in vivo differences associated with patient prognosis. We performed comprehensive molecular profiling of infiltrating CD4+ T cells isolated from untreated invasive primary tumors and found that the infiltrating T cell subpopulations included follicular helper T (Tfh) cells, which have not previously been found in solid tumors, as well as Th1, Th2, ...
Source: Journal of Clinical Investigation - June 17, 2013 Category: Biomedical Science Authors: Chunyan Gu-Trantien, Sherene Loi, Soizic Garaud, Carole Equeter, Myriam Libin, Alexandre de Wind, Marie Ravoet, Hélène Le Buanec, Catherine Sibille, Germain Manfouo-Foutsop, Isabelle Veys, Benjamin Haibe-Kains, Sandeep K. Singhal, Stefan Michiels, Fran� Source Type: research

A 6-Shooter of Magic Bullets in Lung CancerA 6-Shooter of Magic Bullets in Lung Cancer
Drs. Mark Kris and Egbert Smit discuss highlights of the lung cancer sessions at ASCO 2013, including SBRT for early disease, emerging new agents, and the increasing availability of genetic testing. Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Origin of active transport in breast-cancer cells
Soft Matter, 2013, Advance ArticleDOI: 10.1039/C3SM50172H, PaperDiana Goldstein, Tal Elhanan, Maria Aronovitch, Daphne WeihsParticles inside breast-cancer cells are transported among microtubules by thermal-fluctuations, indirect/direct motor interactions, and occasional filament nudging.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)
Source: RSC - Soft Matter latest articles - June 17, 2013 Category: Chemistry Authors: Diana Goldstein Source Type: research

Microfluidics embedded within extracellular matrix to define vascular architectures and pattern diffusive gradients
Lab Chip, 2013, Accepted ManuscriptDOI: 10.1039/C3LC50493J, PaperBrendon Baker, Britta Trappmann, Sarah C Stapleton, Esteban Toro, Christopher S. ChenGradients of diffusive molecules within 3D extracellular matrix (ECM) are essential in guiding many processes such as development, angiogenesis, and cancer. The spatial distribution of factors that guide these processes...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Lab Chip latest articles)
Source: RSC - Lab Chip latest articles - June 17, 2013 Category: Chemistry Authors: Brendon Baker Source Type: research

Bioimaging of targeting cancers using aptamer-conjugated carbon nanodots
Chem. Commun., 2013, Advance ArticleDOI: 10.1039/C3CC42752H, CommunicationChang Hyun Lee, Ramesh Rajendran, Myoung-Seok Jeong, Hae Young Ko, Jin Young Joo, Sujeong Cho, Young Wook Chang, Soonhag KimUsing the excellent emission properties of carbon nanodots, we have developed an aptamer-conjugated imaging probe for targeting cancers.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - June 17, 2013 Category: Chemistry Authors: Chang Hyun Lee Source Type: research

FTIR spectral signature of anticancer drug effects on PC-3 cancer cells: is there any influence of the cell cycle?
Analyst, 2013, 138,3998-4005DOI: 10.1039/C3AN00225J, PaperAllison Derenne, Alix Mignolet, Erik GoormaghtighThe same cells are imaged successively by visible, FTIR and fluorescence imaging techniques.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 17, 2013 Category: Chemistry Authors: Allison Derenne Source Type: research

Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer
Analyst, 2013, 138,3967-3974DOI: 10.1039/C3AN36890D, PaperShangyuan Feng, Duo Lin, Juqiang Lin, Buhong Li, Zufang Huang, Guannan Chen, Wei Zhang, Lan Wang, Jianji Pan, Rong Chen, Haishan ZengCervical cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - June 17, 2013 Category: Chemistry Authors: Shangyuan Feng Source Type: research

J&J Buys Drug Developer Aragon
Johnson & Johnson is acquiring privately held Aragon Pharmaceuticals in a deal potentially valued at $1 billion, in a move to bolster its prostate cancer drug-development business. (Source: WSJ.com: Health)
Source: WSJ.com: Health - June 17, 2013 Category: Pharmaceuticals Tags: PAID Source Type: news

China's 'cancer villages'
Lo Sze Ping, founder of Greenovation Hub, talks about reason for the high incidents of cancer in some Chinese villages. (Source: CNN.com - Health)
Source: CNN.com - Health - June 17, 2013 Category: Consumer Health News Source Type: news

Boston Children’s Hospital To Offer World’s First Hand Transplant Program For Kids
BOSTON (CBS/AP) — A Boston hospital is starting the world’s first hand transplant program for children, and doctors say it won’t be long until face transplants and other radical operations to improve appearance and quality of life are offered to kids, too. WBZ NewsRadio 1030′s Karen Twomey reports play pause Children's Hospital To Start First Hand Transplant Program For Kids Karen Twomey Download ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 17, 2013 Category: Consumer Health News Authors: Kckatzman Tags: Daily Headlines Health Heard On WBZ NewsRadio 1030 Local Watch Listen Boston Children's Hospital CBS Boston Deb Lawler hand transplant program Karen Twomey Source Type: news

Abnormalities In New Molecular Pathway May Increase Breast Cancer Risk
A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. "Genomic instability is an increased tendency for abnormal changes in DNA, like the addition of extra copies of chromosomes, DNA breaks and mutations," said Ji-Hye Paik, Ph.D., assistant professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York, N.Y... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Boston Children’s Hospital To Offer Hand Transplants For Kids
BOSTON (CBS/AP) — A Boston hospital is starting the world’s first hand transplant program for children, and doctors say it won’t be long until face transplants and other radical operations to improve appearance and quality of life are offered to kids, too. “We consider children in a separate category from adults because they have longer to live, theoretically longer to live with the hand transplant and longer exposure to immune-suppressing drugs,” Dr. Amir Taghinia told WBZ NewsRadio 1030.”You need to ask yourself if the risk of the immune-suppressing drugs justifies the improvement in q...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - June 17, 2013 Category: Consumer Health News Authors: Kckatzman Tags: Daily Headlines Health Heard On WBZ NewsRadio 1030 Local Watch Listen Boston Children's Hospital CBS Boston Deb Lawler hand transplant program Karen Twomey Source Type: news

Copper Depletion in Women With Breast CancerCopper Depletion in Women With Breast Cancer
A copper depletion strategy for breast cancer patients with an extraordinarily high-risk of relapse from occult residual disease yields interesting findings about the microenvironment for angiogenesis. Annals of Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Paraneoplastic Necrotizing Myopathy in Lung CancerParaneoplastic Necrotizing Myopathy in Lung Cancer
Paraneoplastic necrotizing myopathy is a recently defined clinical entity, characterized by massive necrosis of muscle fibers. What was the underlying cause in this patient? Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Type 2 Diabetes and Risk of Prostate CancerType 2 Diabetes and Risk of Prostate Cancer
Are patients with type 2 diabetes at a higher risk of developing prostate cancer? Prostate Cancer and Prostatic Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news

Targeting HER2 in Esophageal CancerTargeting HER2 in Esophageal Cancer
Human epidermal growth factor antagonists are being tested in HER2-positive gastric and gastroesophageal junction tumors. Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Cancer Spread May Be Stopped By Blocking Development Protein
A protein that is active in growing embryos but not normal adult tissue, has also been found in various types of cancer. Now a new US study suggests it may switch on metastasis, the ability of cancer cells to spread and form new tumors in other parts of the body. The researchers say it offers a new target for anti-cancer treatments that block the protein without harming healthy cells... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

HEXIM1 Found To Suppresses Breast Cancer Metastasis And Make The Heart Healthier
Researchers at Case Western Reserve University have found that a single gene poses a double threat to disease: Not only does it inhibit the growth and spread of breast tumors, but it also makes hearts healthier. In 2012, medical school researchers discovered the suppressive effects of the gene HEXIM1 on breast cancer in mouse models. Now they have demonstrated that it also enhances the number and density of blood vessels in the heart - a sure sign of cardiac fitness... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Growth Of Aggressive Brain Cancer Driven By Metabolic Molecule
A study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has identified an abnormal metabolic pathway that drives cancer-cell growth in a particular glioblastoma subtype. The finding might lead to new therapies for a subset of patients with glioblastoma, the most common and lethal form of brain cancer. The physician scientists sought to identify glioblastoma subtype-specific cancer stem cells... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Greater Potential Benefit In Overall Survival For Eribulin Compared With Capecitabine For Metastatic Breast Cancer
Subgroup analyses from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate, with capecitabine, a standard chemotherapy medication in women with previously treated metastatic breast cancer, showed increased benefit among women sharing certain traits. Specifically, these analyses demonstrated a greater potential benefit in certain subsets of patients with metastatic breast cancer. This analysis was presented by Peter A. Kaufman, M.D., during the 2013 ASCO Annual Meeting... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Identifying Women Most Likely To Respond To Preventive Breast Cancer Therapy
Newly discovered genetic variations may help predict breast cancer risk in women who receive preventive breast cancer therapy with the selective estrogen receptor modulator drugs tamoxifen and raloxifene, a Mayo Clinic-led study has found. The study is published in the journal Cancer Discovery. "Our findings are important because we identified genetic factors that could eventually be used to select women who should be offered the drugs for prevention," said James Ingle, M.D., an oncologist at Mayo Clinic. Dr... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Osteoporosis Drug Bazedoxifene Stops Growth Of Breast Cancer Cells
Bazedoxifene, an osteoporosis medication which is approved in Europe, stops the growth of breast cancer cells, including those that are resistant to current medications, researchers from the Duke Cancer Institute reported at ENDO 2013 - The Endocrine Society's Annual Meeting in San Francisco, California, June 15th, 2013. The team explained that bazedoxifene not only blocks estrogen so that it cannot fuel breast cancer cell growth, but it also makes sure the estrogen receptor is killed off - it flags the estrogen receptor for destruction... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Non-detection of Epstein-Barr virus and human papillomavirus in a region of high gastric cancer risk indicates a lack of a role for these viruses in gastric carcinomas
Gastric mucosa tissue was collected from patients with gastroduodenal diseases in a region of norrteastern China showing a high risk of gastric cancer incidence. The presence of EBV and HPV were assayed to investigate the relationship between gastric carcinomas and virus infection. Neither EBV nor HPV DNA was detected in tissue from the patients. The role of EBV and HPV in gastric cancer is not well understood and still needs to be clarified. (Source: Genetics and Molecular Biology)
Source: Genetics and Molecular Biology - June 17, 2013 Category: Genetics & Stem Cells Source Type: research

Roche drug approved in Japan for treatment of brain cancer
ZURICH (Reuters) - Japan's health ministry has approved drug Avastin for the treatment of aggressive brain cancer in Japan, Swiss pharmaceuticals company Roche said on Monday. (Source: Reuters: Health)
Source: Reuters: Health - June 17, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

miR‐223: infection, inflammation and cancer
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - June 17, 2013 Category: Internal Medicine Authors: Moritz Haneklaus, Motti Gerlic, Luke A. J. O'Neill, Seth L. Masters Tags: Review Source Type: research

Comparative study analyzing survival and safety of bevacizumab/carboplatin/paclitaxel versus carboplatin/docetaxel in initial treatment of metastatic Her-2-negative breast cancer
Abdel Kader Y, Spielmann M, El-Nahas T, Sakr A, Metwally H (Source: Vascular Health and Risk Management)
Source: Vascular Health and Risk Management - June 17, 2013 Category: Cardiology Source Type: research

Diabetics who use meters to monitor their glucose have better control over disease
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Mount Sinai researchers will demonstrate new data on diabetes self-management, as well as the role of prostastic acid phosphatase in Prostate Cancer bone metastases; identify new molecules that can stimulate the thyroid gland; reveal the prevalence of primary aldosteronism; and show how thyroid autoimmunity may be triggered by endoplasmic reticulum stress. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2013 Category: Global & Universal Source Type: news

Exposure to low doses of BPA linked to increased risk of prostate cancer in human stem cells
(The Endocrine Society) Exposing developing tissue to low levels of the plastic bisphenol A, commonly known as BPA, is linked to a greater incidence of prostate cancer in tissue grown from human prostate stem cells, a new study finds. The results will be presented Monday, June 17, at The Endocrine Society's 95th Annual Meeting in San Francisco. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2013 Category: Global & Universal Source Type: news

Certain types of graft-versus-host disease may increase risk of death, Moffitt researcher says
(H. Lee Moffitt Cancer Center & Research Institute) Joseph Pidala, M.D., M.S., assistant member of the Blood and Bone Marrow Transplant and Immunology programs at Moffitt Cancer Center, and colleagues from the Chronic Graft-Versus-Host Disease Consortium have determined that certain gastrointestinal and liver-related types of chronic graft-versus-host disease are associated with worsened quality of life and death. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2013 Category: Global & Universal Source Type: news

Exposure to BPA in developing prostate increases risk of later cancer
(University of Illinois at Chicago) Early exposure to BPA (bisphenol A) -- an additive commonly found in plastic water bottles and soup can liners -- causes an increased cancer risk in an animal model of human prostate cancer, according to University of Illinois at Chicago researcher Gail Prins. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2013 Category: Global & Universal Source Type: news

Abnormalities in new molecular pathway may increase breast cancer risk
(American Association for Cancer Research) A new molecular pathway involving the gene ZNF365 has been identified and abnormalities in that pathway may predict worse outcomes for patients with breast cancer, according to data published in Cancer Discovery, a journal of the American Association for Cancer Research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2013 Category: Global & Universal Source Type: news

Rationally Designed Sulfamides As Glutamate Carboxypeptidase II (GCPII) Inhibitors
This article is protected by copyright. All rights reserved. This current study explores a new class of GCP II inhibitors, glutamyl sulfamides, which possess a neutral tetrahedral zinc‐binding motif. A small library containing 6 sulfamides was prepared and evaluated for inhibitory potency against purified GCPII. While most inhibitors have potencies in the micromolar range, one showed promising sub‐micromolar potency, with the optimal inhibitor in this series being aspartyl‐glutamyl sulfamide (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - June 17, 2013 Category: Biology Authors: Cindy J. Choy, Melody D. Fulton, Austen L. Davis, Mark Hopkins, Joseph K. Choi, Marc O. Anderson, Clifford E. Berkman Tags: Research Article Source Type: research

Major grant funds UCSC researchers using big data to predict cancer outcomes
(University of California - Santa Cruz) Despite some successes, predicting cancer outcomes based on the molecular signatures in cancer cells remains a major challenge. A new effort, funded by the National Cancer Institute and led by researchers at the University of California, Santa Cruz, aims to clear several key roadblocks that have stymied progress in this field. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 17, 2013 Category: Biology Source Type: news

Preventing eggs' death from chemotherapy
(Northwestern University) Young women who have cancer treatment often lose their fertility because chemotherapy and radiation can damage or kill their immature ovarian eggs, called oocytes. Now, Northwestern Medicine® scientists have found the molecular pathway that can prevent the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function. Scientists achieved this in mice by adding a currently approved chemotherapy drug, imatinib mesylate, to another chemotherapy drug cisplatin. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - June 17, 2013 Category: Global & Universal Source Type: news