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Management of right upper airway patency by a silicon stent in a case of endobronchial metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The tumor was successfully resected using a multidisciplinary approach and a novel method of silicone stent placement using the usual rigid bronchoscopic technique was employed to maintain complete right airway patency. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 20, 2009 Category: Respiratory Medicine Authors: Ran Shioi, Masanori Yasuo, Atsuhito Ushiki, Tsuyoshi Tanabe, Kenji Tsushima, Masayuki Hanaoka, Keishi Kubo, Hideaki Moteki, Yutaka Takumi, Satoshi Kawakami, Masahiro Kurozumi, Yoshiki Hirose Source Type: journals

Outpatient administration of radioactive iodine after total thyroidectomy for pediatric thyroid cancer: A report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Radioactive iodine is used as an anti-cancer reagent for papillary and follicular thyroid carcinomas. Patients that are administered a large dose of radioactive iodine are required to stay alone in an isolated room for several days. Some young children with thyroid carcinoma who cannot take care of themselves are not able to undergo this therapy. We tried outpatient administration of 131I for these patients. In Japan, administration for outpatients is restricted to 500MBq (13.5mCi). We administrated 13mCi 131I to three patients suffering from pediatric thyroid carcinomas. One patient with recurrent follicular car...
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Toru Takano, Katsunari Yane, Takaharu Oue, Naoki Otsuki, Ken-ichi Nibu, Yoh Hidaka Tags: Case reports Source Type: journals

NICE Appraisal Of Sorafenib For Advanced Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of sorafenib for advanced hepatocellular carcinoma (HCC) in patients for whom surgery or therapies in the region the cancer arose have failed or are not suitable. In its latest draft guidance, published yesterday (19 November 2009), NICE does not recommend sorafenib. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

NICE Appraisal Of Sorafenib For Advanced Hepatocellular CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Institute for Health and Clinical Excellence (NICE) is currently appraising the use of sorafenib for advanced hepatocellular carcinoma (HCC) in patients for whom surgery or therapies in the region the cancer arose have failed or are not suitable. In its latest draft guidance, published yesterday (19 November 2009), NICE does not recommend sorafenib. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Alnylam Presents New Pre-clinical Data On ALN-VSP, An RNAi Therapeutic For The Treatment Of Liver CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. ALN-VSP is an RNAi therapeutic currently in a Phase I clinical trial for the treatment of liver cancers, including hepatocellular carcinoma (HCC) and other solid tumors with liver involvement. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: Liver Disease / Hepatitis Source Type: news

In vitro cytotoxic effects of Senecio stabianus Lacaita (Asteraceae) on human cancer cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interesting activity with IC(50) values of 62.7 and 71.1 mug mL(-1) against C32 and LNCaP, respectively. Two compounds identified in the n-hexane extract, linalool and beta-caryophyllene, were found to be active against C32 cells (IC(50) values of 23.2 and 20.1 mug mL(-1), respectively). Among tested constituents, the highest activity was found...
Source: Natural Product Research - November 20, 2009 Category: Biochemistry Authors: Tundis R, Loizzo MR, Bonesi M, Menichini F, Dodaro D, Passalacqua NG, Statti G, Menichini F Tags: Nat Prod Res Source Type: journals

Birt–Hogg–Dubé syndrome: clinical and genetic studies of 10 French familiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We report here the largest series to date of French patients with BHDS. We noted a high prevalence of thyroid nodules and renal cysts. However, the lack of a control group does not allow assessment of whether or not such association with BHDS is fortuitous. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 20, 2009 Category: Dermatology Authors: N. Kluger, S. Giraud, I. Coupier, M.-F. Avril, O. Dereure, B. Guillot, S. Richard, D. Bessis Source Type: journals

Distribution of Helicobacter pylori virulence markers in patients with gastroduodenal diseases in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). Methods: H. pylori infection established by both rapid urease test and histology were studied. The cagA and vacA allelic status was determined by polymerase chain reaction (PCR). Sequencing of vacA i1 and i2 PCR product was carried out. Results: ...
Source: BMC Gastroenterology - November 20, 2009 Category: Gastroenterology Authors: Javed YakoobShahab AbidZaigham AbbasWasim JafriZubair AhmadRashida AhmedMuhammad Islam Source Type: journals

TACE it or leave it: hard choices for intermediate-stage hepatocellular carcinoma patients beyond perfect healthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Liver International)
Source: Liver International - November 20, 2009 Category: Gastroenterology Authors: Markus Peck-Radosavljevic Source Type: journals

Automated uro-oncology data collection: the Cancer Research Uro-Oncology DatabaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To develop a relational database (Cancer Research Uro-Oncology Database, CRUD©) to enable automatic data collection on all urological malignancies within our region, as there is increasing emphasis on good data collection for surgical patients with cancer, and numerous overlapping systems that are amassing data on the same patients. Links have been established between pathological databases, multidisciplinary team data-collection systems and patient-survival monitoring facilities, providing accurate pathology, treatment and survival data on all of uro-oncology patients. We are also developing individual modules for the on...
Source: BJU International - November 20, 2009 Category: Urology & Nephrology Authors: Philip J.S. Charlesworth, Neviana Kilbey, Marian Taylor, Russell Leek, David Cranston, Gareth Turner, Jeremy Crew, Adrian Harris, Andrew Protheroe Source Type: journals

Robotic partial nephrectomy without renal hilar occlusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate operative outcomes among patients undergoing robotic partial nephrectomy (RPN) without renal hilar clamping. This was a prospective observational study of patients undergoing RPN under perfused conditions (pRPN). Patients with solitary, radiographically enhancing renal cortical lesions gave consent for pRPN. Salient demographic data, including age, body mass index (BMI) and preoperative tumour size were obtained. Operative data, including mean operative time, estimated blood loss (EBL), and the presence of any complications, were collected. Renal function was evaluated before and after RPN. Remote adverse event...
Source: BJU International - November 20, 2009 Category: Urology & Nephrology Authors: Wesley M. White, Raj K. Goel, Georges-Pascal Haber, Jihad H. Kaouk Source Type: journals

Targeting Vascular Endothelial Growth Factor in Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor Biol 2009;30:292-299 (DOI:10.1159/000260241) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Neuroendocrine Carcinomas Arising in Solid-Organ Transplant Recipients: Rare but Aggressive MalignanciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oncology 2009;77:314-317 (DOI:10.1159/000260058) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Interleukin-6 Polymorphisms and Gender: Relationship with the Occurrence of Hepatocellular Carcinoma in Patients with End-Stage Liver DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oncology 2009;77:304-313 (DOI:10.1159/000260057) (Source: Karger Publishers)
Source: Karger Publishers - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Ten-year survival analysis for renal carcinoma patients treated with an autologous tumour ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Department of Urology, St. Elisabeth Hospital Straubing, St.-Elisabeth-Strasse 23, 94315, Straubing, Germany. (Source: UroToday)
Source: UroToday - November 19, 2009 Category: Urology & Nephrology Tags: Browse Categories - Renal Cancer Source Type: info

In Response to: Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive ChemoradiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: With interest we have read the paper by Button et al. on patterns of recurrence of esophageal cancer after primary chemoradiotherapy. Their purpose was to ascertain the adequacy of radiotherapy margins by studying the relapse patterns. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Christina T. Muijs, Jannet C. Beukema, Veronique E. Mul, Johannes A. Langendijk Tags: Letters to the Editor Source Type: journals

Answer to Case of the Month #157: Anuria in the Supine PositionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 79-year-old Caucasian man with a history of coronary heart disease and right-sided nephrectomy for renal cell carcinoma was admitted to the hospital with an acute confusional state secondary to narcotic overdose. On admission, all initial laboratory work was normal including a creatinine level of 1.1 mg/dL and a blood urea nitrogen level of 28 mg/dL. The patient's mental status improved after the adjustment of his narcotics. However, on day 4 of hospitalization, the patient developed anuria and his creatinine and blood urea nitrogen levels increased to 5.5 mg/dL and 60.0 mg/dL, respectively (). (Source: Canadian Associat...
Source: Canadian Association of Radiologists Journal - November 19, 2009 Category: Radiology Authors: Bilal Mujtaba, M. Fuad Jan Tags: Canadian Residents' Corner Source Type: journals

Hepatic Segments and Vasculature: Projecting CT Anatomy onto Angiograms [Online Only]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatic transarterial interventional therapies such as chemoembolization and radiation embolization are important treatment options for hepatocellular carcinoma. Understanding the anatomy of individual arterial branches and hepatic segments is critical for selecting the correct embolization technique for treatment and to avoid complications. The authors describe the morphologic characteristics of hepatic arterial branches (and their mimickers) and hepatic segments on conventional angiograms. These vessels and segments include the celiac artery, the common and proper hepatic arteries, the left and right hepatic arteries and...
Source: Radiographics recent issues - November 19, 2009 Category: Radiology Authors: Furuta, T., Maeda, E., Akai, H., Hanaoka, S., Yoshioka, N., Akahane, M., Watadani, T., Ohtomo, K. Tags: Online Only Source Type: journals

Best Cases from the AFIP: Renal Cell Carcinoma Manifesting as a Solitary Bone Metastasis [AFIP Archives]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiographics recent issues)
Source: Radiographics recent issues - November 19, 2009 Category: Radiology Authors: Setlik, D. E., McCluskey, K. M., McDavit, J. A. Tags: Musculoskeletal Radiology, Oncologic Imaging, Genitourinary Radiology AFIP Archives Source Type: journals

Nonmelanoma skin cancer in vitiligo patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: In the June 2009 issue of the Journal, Hexsel et al reported the incidence of nonmelanoma skin cancer (NMSC) in a cohort of patients with vitiligo. In the “Introduction” section, they noted that the frequency of skin cancer in patients with vitiligo seems to be uncommon, with only a few reports in the literature. They identified 477 patients at their hospital with vitiligo, six of whom (42% of the study group) had a NMSC. Four were basal cell carcinomas, and two were squamous cell carcinomas (SCCs). The pathology specimens were stained for the presence of melanocytes. Two of the six cancers arose in viti...
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: James J. Nordlund Tags: Notes & Comments Source Type: journals

Initial presentation of stasis dermatitis mimicking solitary lesions: A previously unrecognized clinical scenarioEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Stasis dermatitis may present as a solitary lesion mimicking a neoplasm. Early recognition of stasis dermatitis can lead to appropriate treatment and possibly prevent further morbidity. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Joshua Weaver, Steven D. Billings Tags: Dermatopathology Source Type: journals

A Case Report of Tongue Metastasis from Lung CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

The Clinical Analysis of 21 Patients with Lymphoepithelioma-like Carcinoma after OperationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Lymphoepitheliomalike carcinoma of the lung is a very rare and unique subtype of large cell carcinomas of the lung, which has a better prognosis with surgical, chemotherapy and radiotherapy. (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2009 Category: Cancer & Oncology Source Type: journals

Unexplained Liver Hemorrhage After Metastasis Radiofrequency AblationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: Colorectal Cancer Source Type: news

Columnar cell lesions and pseudoangiomatous hyperplasia like stroma: is there an epithelial-stromal interaction?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The significance of association between cancer and its microenvironment has been increasingly recognized. It has been shown in animal models that interaction between neoplastic epithelial cells and adjacent stroma can modulate tumor behavior. Carcinoma associated stromal cells can transform normal epithelial cells into neoplastic cells. In breast, columnar cell lesions are non-obligate precursors of low grade ductal carcinoma in situ. Columnar cell lesions can be seen intimately associated with PASH-like-stroma, a lesion we termed as CCPLS. Our aim is to investigate epithelial-stromal interactions in CCPLS and compare ...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Recavarren RA, Chivukula M, Carter G, Dabbs DJ Tags: Int J Clin Exp Pathol Source Type: journals

The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
GATA4 is a transcription factor that plays a role in regulating the normal development of many mesoderm and endoderm derived tissues, including the pancreas. Silencing of GATA4 mRNA expression by promoter methylation has been implicated in carcinogenesis of the ovary, lung and colorectum. By contrast, GATA4 mRNA expression is upregulated in pancreatic cancer cell lines and tissues. To further clarify the relationship of GATA4 to pancreatic cancer, we immunolabeled 90 samples of pancreatic ductal adenocarcinoma using a GATA4 specific monoclonal antibody. Both the intensity and percent of labeling was recorded for each c...
Source: International Journal of Clinical and Experimental Pathology - November 19, 2009 Category: Pathology Authors: Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA Tags: Int J Clin Exp Pathol Source Type: journals

ImmunoGen, Inc. Announces Encouraging Clinical Data With Its IMGN901 Compound In The Treatment Of Merkel Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics, today reported encouraging clinical data with its IMGN901 product candidate in the treatment of Merkel cell carcinoma (MCC). Meaningful evidence of anticancer activity has been noted among the limited number of patients with MCC who have received IMGN901. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

ImmunoGen, Inc. Announces Encouraging Clinical Data With Its IMGN901 Compound In The Treatment Of Merkel Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ImmunoGen, Inc. (Nasdaq: IMGN), a biopharmaceutical company that develops targeted anticancer therapeutics, today reported encouraging clinical data with its IMGN901 product candidate in the treatment of Merkel cell carcinoma (MCC). Meaningful evidence of anticancer activity has been noted among the limited number of patients with MCC who have received IMGN901. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 19, 2009 Category: Cancer & Oncology Tags: Cancer / Oncology Source Type: news

Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Transfection of Ang-1 into human gastric cancer cell line BGC-823 can significantly increase expression of integrin beta1 and CD44V6, by which cell adhesion and metastasis to the ECM are promoted. PMID: 19916173 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Ou XL, Chen HJ, Sun WH, Hang C, Yang L, Guan YY, Yan F, Chen BA Tags: World J Gastroenterol Source Type: journals

Association between Helicobacter pylori seropositivity and digestive tract cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma. PMID: 19916178 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Wu IC, Wu DC, Yu FJ, Wang JY, Kuo CH, Yang SF, Wang CL, Wu MT Tags: World J Gastroenterol Source Type: journals

Efficacy of surgical resection in management of isolated extrahepatic metastases of hepatocellular carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: SR can provide survival benefits for patients with 1 or 2 isolated extrahepatic metastases and who concurrently exhibit good hepatic functional reserve and general performance status as well as successful treatment of intrahepatic HCC. PMID: 19916180 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Chan KM, Yu MC, Wu TJ, Lee CF, Chen TC, Lee WC, Chen MF Tags: World J Gastroenterol Source Type: journals

Small invasive ductal carcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of small adenocarcinoma of the pancreas distinct from branch duct intraductal papillary mucinous neoplasm (IPMN) in which investigation by EUS took place every 6 mo and diagnosis was made accurately by additional CEH-EUS during the follow-up of the branch duct IPMN. A 68-year-old female was admitted to our hospital because of a branch duct IPMN in the pancreatic body. She had been followed-up by EUS every 6 mo. However, after 2 years EUS demonstrated a low echoic area distinct from the branch duct IPMN which was vaguely discernible by EUS, and accurate sizing and differential diagnosis were con...
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Sakamoto H, Kitano M, Komaki T, Imai H, Kamata K, Kimura M, Takeyama Y, Kudo M Tags: World J Gastroenterol Source Type: journals

Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy. We analyzed the influence of I105V polymorphism of GSTP1 on clinico-pathological features and outcomes in 166 Chinese patients with metastatic colorectal carcinoma who had been treated with first-line FOLFOX-4. Combined analysis of GSTP1 I105V, ERCC1-118, and XPD-751 polymorphisms was also conducted. The results showed that, in comparison with Caucasian populations, a remarkably lower prevalence of Val105 allele variants was noted (24.7%). Patients w...
Source: Cancer Science - November 19, 2009 Category: Cancer & Oncology Authors: Yen-Chung Chen, Cheng-Hwai Tzeng, Po-Min Chen, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kae Jiang, Huann-Sheng Wang, Wei-Shu Wang Source Type: journals

Chemotherapy intensity and toxicity among black and white women with advanced and recurrent endometrial cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to confirm whether black and white women with endometrial cancer are equally tolerant of chemotherapy and identify factors that impact survival.A retrospective review of 169 black women and 982 white women with the International Federation of Gynecologists and Obstetricians stage III, stage IV, or recurrent endometrial carcinoma was performed. All patients received doxorubicin combined with cisplatin. Chemotherapy parameters that were reviewed included relative dose, relative time, and relative dose intensity. Treatment cycles [ge]7 were defined as treatment completion.Although black patients ...
Source: Cancer - November 19, 2009 Category: Cancer & Oncology Authors: John H. Farley, Chunqiao Tian, G. Scott Rose, Carol L. Brown, Michael Birrer, John I. Risinger, J. Tate Thigpen, Gini F. Fleming, Holly H. Gallion, G. Larry Maxwell Source Type: journals

Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: S. gallolyticus most likely plays an essential role in the oncogenic progression of normal colorectal mucosa to adenoma and to CRC. This promoting/propagating role of S. gallolyticus might take place by utilizing certain inflammatory, anti-apoptotic, and angiogenic factors of transformation including NF-kappaB and IL-8. (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Ahmed AbdulamirRand HafidhLayla MahdiTarik AljebooriFatimah Abu bakar Source Type: journals

Initial activation of EpCAM cleavage via cell-to-cell contactEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine). (Source: BMC Cancer)
Source: BMC Cancer - November 19, 2009 Category: Cancer & Oncology Authors: Sabine DenzelDorothea MaetzelBrigitte MackCarola EggertGabriele BaerrOlivier Gires Source Type: journals

Early Response to Neo-adjuvant Chemotherapy in Carcinoma of the Breast Predicts Both Successful Breast-Conserving Surgery and Decreased Risk of Ipsilateral Breast Tumor RecurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the early response to neo-adjuvant chemotherapy may be a useful predictor of both selection of surgical method and IBTR risk. (Source: The Breast Journal)
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Makoto Ishitobi, Yoshifumi Komoike, Kazuyoshi Motomura, Hiroki Koyama, Hideo Inaji Source Type: journals

Clinical Implications of Subcategorizing BI-RADS 4 Breast Lesions associated with Microcalcification: A Radiology–Pathology Correlation StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Currently radiologists have the option of subcategorizing BI-RADS 4 breast lesions into 4A (low suspicion for malignancy), 4B (intermediate suspicion of malignancy), and 4C (moderate concern, but not classic for malignancy). To determine the clinical significance of BI-RADS 4 subcategories and the common pathologic changes associated with these mammographic lesions, a retrospective review of 239 consecutive stereotactic-needle core biopsies (SNCB) for microcalcifications was performed. All 239 SNCBs were BI-RADS 4 lesions, and of these, 191 were subcategorized to 4A, 4B or 4C. Ninety-four of 191 (49%) were 4A, 73...
Source: The Breast Journal - November 19, 2009 Category: Cancer & Oncology Authors: Mary Ann Sanders, Lane Roland, Sunati Sahoo Source Type: journals

NICE issues negative Final Appraisal Determination on sorafenib (first line) for advanced and metastatic hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: NICE Area: News In its Final Appraisal Determination, NICE has not recommended the use of sorafenib (first line) for the treatment of advanced and metastatic hepatocellular carcinoma in patients for whom surgical or locoregional therapies have failed or are not suitable, as it was not considered a cost-effective use of NHS resources. The appeal period for this appraisal will close on 3rd December 2009. (Source: NeLM - Oncology)
Source: NeLM - Oncology - November 19, 2009 Category: Cancer & Oncology Source Type: organizations

Clinical manifestations and survival of patients with hepatocellular carcinoma and cardiac metastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Hepatocellular carcinoma patients with cardiac metastases were in the advanced stages. These patients had limited survival from the diagnosis of cardiac metastases. The most common cause of death was related to HCC per se or the underlying liver disease. Only a few patients expired because of cardiac metastases. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Yu-Chun Liu, Yi-Lwun Ho, Guan-Tarn Huang, Ding-Shinn Chen, Jin-Chuan Sheu, Chien-Hung Chen Source Type: journals

Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Laparoscopic splenectomy may be superior to partial splenic embolization as a supportive intervention for cirrhotic patients with hypersplenism. Future prospective, randomized controlled patient studies are required to confirm these findings. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Morimasa Tomikawa, Tomohiko Akahoshi, Keishi Sugimachi, Yasuharu Ikeda, Kisaku Yoshida, Yuichi Tanabe, Hirofumi Kawanaka, Kenji Takenaka, Makoto Hashizume, Yoshihiko Maehara Source Type: journals

Gastric metastasis of hepatocellular carcinoma via a possible existing retrograde hematogenous pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: When cirrhotic patients with portal hypertension have HCC with PVT, a hematogenous pathway can exist for gastric metastasis of tumor thrombi involving hepatofugal flow to the stomach after TAE or EVL apart from the major pathway of direct invasion. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Ming-Luen Hu, Wei-Chen Tai, Seng-Kee Chuah, Yi-Chun Chiu, Keng-Liang Wu, Yeh-Pin Chou, Chung-Mou Kuo, Tsung-Hui Hu, King-Wah Chiu Source Type: journals

Radiofrequency ablation therapy for hepatocellular carcinoma in elderly patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Elderly HCC patients, who have good performance status, should be treated in the same manner and with the same strategy as young HCC patients. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Atsushi Hiraoka, Kojiro Michitaka, Norio Horiike, Satoshi Hidaka, Takahide Uehara, Soichi Ichikawa, Aki Hasebe, Yasunao Miyamoto, Tomoyuki Ninomiya, Ichiro Sogabe, Yoshihiro Ishimaru, Hideki Kawasaki, Yohei Koizumi, Masashi Hirooka, Yoshimasa Yamashita, M Source Type: journals

Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migratio...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Pau Sancho-Bru, Elena Juez, Montserrat Moreno, Valeria Khurdayan, Manuel Morales-Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginès, Ramón Bataller Source Type: journals

Cervical cytology in patients with postmenopausal bleedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, the role of cervical cytology in the diagnosis of post or perimenopausal (PM) bleeding was explored. A total of 135 patients with PM bleeding were selected. In all these cases both conventional cervical cytology and histopathology follow up were available. The commonest causes of postmenopausal (PM) bleeding with abnormal histopathology were squamous cell carcinoma of cervix (14), endocervical polyp (13), endometrial adenocarcinomas (13) and simple hyperplasia without atypia (13). There were a total 13 cases of endometrial adenocarcinoma and cervical smears of these cases were reported as high grade squamous...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Jasleen Kaur, Pranab Dey, Subhash Chandra Saha, Arvind Rajwanshi, Raje Nijhawan, Srinivasan Radhika, Nalini Gupta Source Type: journals

Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 × 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these ...
Source: Diagnostic Cytopathology - November 19, 2009 Category: Pathology Authors: Akihiko Kawahara, Hiroshi Harada, Hiroyuki Mihashi, Jun Akiba, Masayoshi Kage Source Type: journals

Human epididymis protein 4 is a biomarker for transitional cell carcinoma in the urinary systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: To investigate human epididymis protein 4 (HE4) levels in transitional cell carcinoma (TCC) of the urinary system and its relationship with clinicopathological features.Methods: 102 patients with TCC, 60 with benign urinary diseases, and 60 healthy controls were included in this study. The HE4 levels were used to analyze different clinicopathologic characteristics and changes between pre- and postsurgical operation.Results: The HE4 level was significantly increased in patients with TCC compared to patients with benign urinary diseases patients (P (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 19, 2009 Category: Laboratory Medicine Authors: Zhu Xi, Ma LinLin, Tian Ye Tags: Original Articles Source Type: journals

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management [REVIEW ARTICLE]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion MRI detects contralateral lesions in a substantial proportion of women, but does not reliably distinguish benign from malignant findings. Relatively high ICDR may be due to selection bias and/or overdetection. Women must be informed of the uncertain benefit and potential harm, including additional investigations and surgery. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Brennan, Houssami, Lord, Macaskill, Irwig, Dixon, Warren, Ciatto Tags: Diagnosis & Staging REVIEW ARTICLE Source Type: journals

Dose Finding and Early Efficacy Study of Gemcitabine Plus Capecitabine in Combination With Bevacizumab Plus Erlotinib in Advanced Pancreatic Cancer [Gastrointestinal Cancer]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The maximum-tolerated dose of capecitabine was 1,660 mg/m2. The recommended capecitabine dose in this cytotoxic doublet/biologic doublet regimen is 1,440 mg/m2; this regimen is under evaluation in an ongoing phase II study. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 18, 2009 Category: Cancer & Oncology Authors: Starling, Watkins, Cunningham, Thomas, Webb, Brown, Thomas, Oates, Chau Tags: Chemotherapy Gastrointestinal Cancer Source Type: journals