Carcinosarcoma This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Cytologic features of the endometrial adenocarcinoma: Comparison of ThinPrep and BD surepath preparations
We compared the cytoarchitectural features used for the cytologic diagnosis of endometrial adenocarcinoma (EC) using ThinPrep® (TPS = ThinPrep Sample) and BD SurePath™ (SPS = SurePath Sample) preparations. In 20 patients, a direct endometrial sample using the Uterobrush was obtained. Nineteen cases of EA and one case of carcinosarcoma were studied. TPS and SPS were performed according to the manufacturer's recommendations. Moreover, after the TPS preparation, the residual material was also used to prepare an SPS sample (TP–SPS = ThinPrep–Surepath sample). The following points were investigated in both preparations: ...
Source: Diagnostic Cytopathology - February 26, 2013 Category: Pathology Authors: Yoshiaki Norimatsu, Shingo Sakamoto, Hiroyuki Ohsaki, Satoru Ozaki, Toshiro Yokoyama, Keiko Shimizu, Kenji Yanoh, Minoru Akiyama, Masamichi Bamba, Tadao K. Kobayashi Tags: Original Article Source Type: research

Primary Cutaneous Carcinosarcoma of the Shoulder: Case Report with Literature Review
(Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 3, 2012 Category: Dermatology Authors: Sun Hwa Hong, Suk‐Joo Hong, Youngsuk Lee, Eun‐Young Kang Tags: Communications and Brief Reports Source Type: research

Sinonasal teratocarcinosarcoma with intracranial extension: Case report and literature review.
We report the case of a 58-year-old white man who presented with a 1-year history of a gradually enlarging left-sided nasal mass. The patient had previously undergone endoscopic sinus surgery at another facility, and the final pathologic specimen was reported as an SNTCS with positive margins. He was then referred to our institution, where he underwent a craniofacial resection combined with endoscopic intranasal resection. Postoperatively, he received combined chemotherapy and irradiation. At 48 months of follow-up, he was alive without evidence of disease. PMID: 23288820 [PubMed - in process] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - December 1, 2012 Category: ENT & OMF Authors: Wassef SN, Kapur P, Barnett SL, Myers LL Tags: Ear Nose Throat J Source Type: research

Very rare case of rectal carcinosarcoma
Content Type Journal ArticleCategory CorrespondencePages 1-3DOI 10.1007/s10151-012-0947-xAuthors M. Kołodziejczak, Department of General Surgery, Proctology Unit, Solec Hospital, 93 Solec str., 00-382 Warsaw, PolandK. Bielecki, Department of General Surgery, Proctology Unit, Solec Hospital, 93 Solec str., 00-382 Warsaw, PolandI. Sudoł-Szopińska, Department of Diagnostic Imaging, Institute of Rheumatology, Warsaw, PolandA. Szcześniak, Pathomorphology Department, Solec Hospital, Warsaw, PolandA. Obcowska, Department of General Surgery, Praski Hospital, Warsaw, Poland Journal Techniques in ColoproctologyOnline ...
Source: Techniques in Coloproctology - November 25, 2012 Category: Surgery Tags: Techniques in Coloproctology Source Type: research

Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats.
Abstract Cancer cachexia is a multifactorial syndrome characterised by progressive weight loss, frequently accompanied by anorexia, sarcopenia, and chronic systemic inflammation. The white adipose tissue is markedly affected by cachexia and contributes to this syndrome throught the secretion of pro-inflammatory factors which reach the adjacent tissues and the circulation. A nonpharmacologic intervention that may attenuate cancer cachexia is chronic physical activity, but the effect of resistance training upon adipose tissue inflammation in cachexia has never been examined. For that purpose we designed a protocol in...
Source: Cytokine - November 21, 2012 Category: Molecular Biology Authors: Donatto FF, Neves RX, Rosa FO, Camargo RG, Ribeiro H, Matos-Neto EM, Seelaender M Tags: Cytokine Source Type: research

Thymic carcinosarcoma consisting of sarcomatous and adenosquamous carcinomatous component.
PMID: 23158163 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - November 1, 2012 Category: Journals (General) Authors: Liu YG, Sun KK, Sui XZ, Li JF, Wang J Tags: Chin Med J (Engl) Source Type: research

Duodenal protrusion by carcinosarcoma of the extrahepatic bile duct
(Source: Digestive Endoscopy)
Source: Digestive Endoscopy - October 18, 2012 Category: Gastroenterology Authors: Masaki Tanaka, Tetsuo Ajiki, Ippei Matsumoto, Sadaki Asari, Takumi Fukumoto, Atsuhiro Masuda, Hideyuki Shiomi, Takanobu Hayakumo, Yonson Ku Tags: LETTERS, TECHNIQUES AND IMAGES Source Type: research

Energy controllable steep pulse (ECSP) treatment suppresses tumor growth in rats implanted with walker 256 carcinosarcoma cells through apoptosis and an antitumor immune response.
Abstract Electrochemotherapy has been widely used for the treatment of solid tumors, although the underlying mechanism remains unclear. We aimed to investigate the effects of energy controllable steep pulse (ECSP) on the regulation of tumor growth and apoptosis in rats implanted with Walker 256 carcinosarcoma cells. A rat tumor model was established by injection of Walker 256 carcinosarcoma cells into the inguinal area. H&E staining, transmission electron microscopy, and the TUNEL assay were used to detect apoptosis. Concanavalin A-induced lymphocyte transformation and MTT assays were used to assess lymphocyte ...
Source: Oncology Research - October 14, 2012 Category: Cancer & Oncology Authors: Luo XD, Sun JC, Liu F, Hu LN, Dong XJ, Sun DN, Xiao J Tags: Oncol Res Source Type: research

Pulmonary carcinosarcoma successfully resected using the rib-cross thoracotomy approach: report of a case
Abstract Pulmonary carcinosarcoma is extremely rare and disease prognosis is very poor. A solid large tumor occupying the left thorax was detected in a 66-year-old female. Rib-cross thoracotomy was performed to excise the tumor; the 5th and 6th ribs and intercostal muscles and vessels were cut along the mid-axillary line, and the thorax was entered posteriorly at the 4th intercostal space and anteriorly at the 6th intercostal space, providing wide exposure of the entire thorax. Left pneumonectomy combined with chest wall resection was successfully performed, followed by chest reconstruction to achieve comple...
Source: Surgery Today - October 12, 2012 Category: Surgery Tags: Surgery Today Source Type: research

[Uterine Carcinosarcoma induced by a vaginal foreign body: A case report and review.]
We report a case of uterine carcinosarcoma induced by a vaginal foreign body, forgotten nine years before. PMID: 23062745 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - October 9, 2012 Category: OBGYN Authors: Osman K, Abdellaoui B, Weyl B, Levêque J Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: research

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial‐Mesenchymal Transition is not a necessary step
This article discusses some of the controversies surrounding differentiation and metastasis from a clinicopathologic perspective and presents evidence that the epithelial phenotype is maintained throughout the process of cancer metastasis. (Source: International Journal of Cancer)
Source: International Journal of Cancer - September 28, 2012 Category: Cancer & Oncology Authors: Michael Herman Chui Tags: Mini Review Source Type: research

Esophageal Carcinosarcoma: A Unique Entity with Better Prognosis
Conclusions Our study identified the baseline NLR to be an independently prognostic factor for curatively resected esophageal carcinosarcoma. Content Type Journal ArticleCategory Thoracic OncologyPages 1-8DOI 10.1245/s10434-012-2658-yAuthors Liang Wang, Department of Hematologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of ChinaYongbin Lin, Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of ChinaHao Long, Department of Thoracic Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guang...
Source: Annals of Surgical Oncology - September 26, 2012 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: research

Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature
Conclusion: The observed molecular and cytogenetic findings may provide additional tools for the differential diagnosis of biphasic pulmonary neoplasms. Furthermore, TP53, MDM2, CDK4, and PTPN1 may be involved in tumourigenesis. (Source: BMC Cancer)
Source: BMC Cancer - September 25, 2012 Category: Cancer & Oncology Authors: Inga-Marie SchaeferCarsten-Oliver SahlmannTobias OverbeckStefan SchweyerJan Menke Source Type: research

Metastasizing Pleomorphic Adenoma Presents Intraorally: A Case Report and Review of the Literature
We report the first, to our knowledge, example of MPA with alveolar bone metastasis. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - September 17, 2012 Category: ENT & OMF Authors: Matthew D. Reiland, Ioannis G. Koutlas, Raj Gopalakrishnan, Andrew G. Pearson, David L. Basi Tags: Pathology Source Type: research

A Multi-Institutional Cohort Study of Adjuvant Therapy in Stage I–II Uterine Carcinosarcoma
Results of this multi-institutional, retrospective study of women with stage I or II uterine carcinosarcoma who received adjuvant chemotherapy with or without radiotherapy showed an increase in PFS with... (Source: OncologySTAT Journal Scans)
Source: OncologySTAT Journal Scans - September 14, 2012 Category: Cancer & Oncology Source Type: research

Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis
Summary: The molecular events implicated in the development of endometrial carcinosarcoma remain poorly understood. Using complementary DNA microarrays, we analyzed a group of 15 endometrial carcinosarcomas and compared their gene expression profiles with those obtained from a group of 23 endometrioid endometrial carcinomas. We demonstrated changes in the expression of genes modulating processes such as the epithelial to mesenchymal transition, muscle differentiation, the expression of cancer/testis antigens, and immune response in endometrial carcinosarcomas. The high mobility group AT-hook 2 gene is an embryonic nuclear ...
Source: Human Pathology - September 12, 2012 Category: Pathology Authors: Laura Romero-Pérez, María Ángeles Castilla, María Ángeles López-García, Juan Díaz-Martín, Michele Biscuola, Susana Ramiro-Fuentes, Esther Oliva, Xavier Matias-Guiu, Jaime Prat, Amparo Cano, Gema Moreno-Bueno, José Palacios Tags: Original Contributions Source Type: research

A distinctive epitheliomesenchymal biphasic tumor in the duodenum: the first case of duodenoblastoma?
This report describes a duodenal location of a similar epitheliomesenchymal biphasic tumor in a 22-year-old woman. To our knowledge, this is the first reported case occurring primarily in the duodenum and might be the first case of “duodenoblastoma.” Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00428-012-1307-yAuthors F Poizat, Department of Biopathology, Paoli Calmettes Institut, 232 Bd Sainte Marguerite, 13009 Marseille, FranceC de Chaisemartin, Department of Surgery, Paoli Calmettes Institut, 232 Bd Sainte Marguerite, 13009 Marseille, FranceE Bories, Department of Endoscopy, Pa...
Source: Virchows Archiv - September 7, 2012 Category: Pathology Tags: Virchows Archiv Source Type: research

Growth inhibition of Walker carcinosarcoma 256 with alcoholic extract of green tea leaves (Camellia sinensis).
CONCLUSION: Alcoholic extracts of green tea have antitumor activity. PMID: 22936089 [PubMed - in process] (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - September 1, 2012 Category: Surgery Authors: Ponte MF, Targino TS, Mota MA, Landim JS, Ribeiro TR, Soares FP, Pereira MR, Silva SL, Silva SF Tags: Acta Cir Bras Source Type: research

Serum CA 125, CA 15-3, CEA, and CA 19-9: a prognostic factor for uterine carcinosarcomas?
Conclusion In this retrospective study, none of the preoperative serum tumor markers, neither epithelial component, histological type, nor grade showed a significant association with prognosis. This null finding may have significant implications in the common clinical practice; given that there is a controversy in the literature regarding the role and the significance of the prognostic significance of serum CEA, CA 125, CA 19-9, and CA 15-3. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-6DOI 10.1007/s00404-012-2529-6Authors Nikolaos Thomakos, Department of Obstetrics and Gynecolo...
Source: Archives of Gynecology and Obstetrics - August 31, 2012 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

High grade serous carcinoma of the ovary with a yolk sac tumour component in a postmenopausal woman: report of an extremely rare phenomenon
High grade serous carcinoma is the most common ovarian epithelial malignancy.1 Ovarian yolk sac tumours (YST) are much more uncommon and are morphologically heterogeneous, primitive teratoid neoplasms differentiating into multiple endodermal structures.2 They almost always occur before age 30 and are extremely rare in perimenopausal and postmenopausal women. Rare examples have been reported in elderly patients, sometimes associated with an ovarian surface epithelial-stromal tumour, most commonly endometrioid adenocarcinoma but occasionally carcinosarcoma, clear cell carcinoma or a mucinous neoplasm; rarely the epithelial c...
Source: Journal of Clinical Pathology - August 28, 2012 Category: Pathology Authors: Varia, M., McCluggage, W. G., Oommen, R. Tags: PostScript Source Type: research

Rapidly deforming gastric carcinosarcoma with osteoblastic component: An autopsy case report.
In this report, we describe a case of gastric carcinosarcoma and presume its tumorigenesis based on the autopsy findings. PMID: 22912559 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - August 14, 2012 Category: Gastroenterology Authors: Yoshida H, Tanaka N, Tochigi N, Suzuki Y Tags: World J Gastroenterol Source Type: research

Serum neopterin levels in female dogs with malignant mammary tumours
In this study, we have determined serum neopterin levels in female dogs with primary malignant mammary tumours. The study involved 50 female dogs which had a malignant mammary tumours removed surgically (32 animals with carcinoma, 12 animals with sarcoma and 6 animals with carcinosarcoma) and 10 clinically healthy female dogs. Serum neopterin levels were determined using a commercial ELISA kit. The mean neopterin levels were lower in the malignant tumour groups than in healthy animals but differences were statistically significant only in carcinoma and sarcoma groups. The decrease of neopterin levels in animals with malign...
Source: Veterinary and Comparative Oncology - August 9, 2012 Category: Veterinary Research Authors: M. Szczubiał, R. Dąbrowski, W. Łopuszyński Tags: Original Article Source Type: research

Eight cases of malignant mixed müllerian tumor (carcinosarcoma) of the uterus: Findings in surepath™ cervical cytology
We present a series of eight cases of uterine MMMT in SurePath™ cervical samples.The mean age of the women was 65.5 years (range, 60–82 years) and the most common presenting symptom was postmenopausal bleeding. Three out of the eight cases had both epithelial and sarcomatous elements in highly cellular cervical samples. In two cases, abnormal glandular cell clusters were closely associated with the mesenchymal component. The glandular component was usually represented by three‐dimensional clusters of malignant glandular cells and a dispersed population of large, round to oval malignant epithelial cells with single pr...
Source: Diagnostic Cytopathology - August 4, 2012 Category: Pathology Authors: Nalini Gupta, Nicholas Dudding, J. H. F. Smith Tags: Brief Report Source Type: research

Carcinosarcoma ex Non-Recurrent Pleomorphic Adenoma Composed of TTF-1 Positive Large Cell Neuroendocrine Carcinoma and Myofibrosarcoma: Apropos a Rare Case
We present a carcinosarcoma ex non-recurrent pleomorphic adenoma composed of a large cell neuroendocrine carcinomatous component and a spindle cell sarcoma with myofibroblastic differentiation. The tumor contained a hyalinized transition zone where the classical PA appeared to acquire two different histopathological patterns of malignant transformation of the epithelial component. The carcinomatous component was strongly and diffusely positive for low-molecular weight cytokeratins (AE1-3), synaptophysin, thyroid transcription factor-1 and focally positive for chromogranin A. All these markers were negative in the sarco...
Source: Head and Neck Pathology - July 30, 2012 Category: Pathology Tags: Head and Neck Pathology Source Type: research

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial mesenchymal transition is not a necessary step
AbstractEpithelial‐mesenchymal transition (EMT) has been implicated as the critical event initiating cancer invasion and metastasis. After disseminating through the circulation, the malignant cells have been proposed to undergo subsequent mesenchymal‐epithelial transition (MET) to form secondary tumours. However, strong evidence from human tumour specimens for this paradigm is lacking. In carcinomas, cancers derived from epithelial tissues, epithelial morphology and gene expression are almost always retained to some degree. While mesenchymal transdifferentiation may be involved in the pathogenesis of carcinosarcomas, e...
Source: International Journal of Cancer - July 28, 2012 Category: Cancer & Oncology Authors: Michael Herman Chui Tags: Mini Review Source Type: research

Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
CONCLUSION: There are differences in the biology of type II endometrial cancers that develop in women with prior tamoxifen exposure. Tamoxifen associated cancers show higher expression of IGF-1R and mTOR, which should be further investigated. PMID: 22835717 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 24, 2012 Category: Cancer & Oncology Authors: Tergas AI, Buell-Gutbrod R, Gwin K, Kocherginsky M, Temkin SM, Fefferman A, Lengyel E, Yamada SD Tags: Gynecol Oncol Source Type: research

A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: A Gynecologic Oncology Group study.
CONCLUSIONS: Treatment with thalidomide met the protocol specified goal of prolonging PFS at 6months. However, based on results with newer agents, the activity was insufficient to support further investigation. Association between pre-treatment VEGFA and prognosis in this population supports further evaluation of anti-angiogenic therapies in uterine carcinosarcoma. PMID: 22796461 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - July 14, 2012 Category: Cancer & Oncology Authors: McMeekin DS, Sill MW, Darcy KM, Abulafia O, Hanjani P, Pearl ML, Rubin SC, Rose PG, Small L, Benbrook DM Tags: Gynecol Oncol Source Type: research

Clinicopathological Characteristics and Outcome of Primary Sarcomatoid Carcinoma and Carcinosarcoma of the Liver
Conclusions SC and CS were highly aggressive malignancies with similar poor survival regardless of the histological and immunohistochemical findings. Early detection through regular physical examination and treatment with radical resection may improve the outcome of those patients. Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s11605-012-1946-yAuthors Qi-Bo Wang, Department of Hepatobiliary Surgery, Cancer Center of Sun Yat-Sen University, 651 Dongfeng Road East, Guangzhou, 510060 People’s Republic of ChinaBo-Kang Cui, Department of Hepatobiliary Surgery, Cancer Center...
Source: Journal of Gastrointestinal Surgery - July 6, 2012 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: research

Diagnosis and treatment of sarcoma of the uterus. A review.
Conclusion. There are differences in survival between histological types of US. LMS and ESS can be divided into different prognostic groups and should be treated separately. PMID: 22793037 [PubMed - in process] (Source: Acta Oncologica)
Source: Acta Oncologica - July 1, 2012 Category: Cancer & Oncology Authors: Tropé CG, Abeler VM, Kristensen GB Tags: Acta Oncol Source Type: research

A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma.
CONCLUSIONS: In women with FIGO stage I-II uterine carcinosarcoma, adjuvant chemotherapy is associated with improved PFS compared to radiation or observation alone. Ongoing clinical trials will clarify the role of chemotherapy in women with this disease. PMID: 22727985 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - June 20, 2012 Category: Cancer & Oncology Authors: Cantrell LA, Havrilesky L, Moore DT, O'Malley D, Liotta M, Secord AA, Nagel CI, Cohn DE, Fader AN, Wallace AH, Rose P, Gehrig PA Tags: Gynecol Oncol Source Type: research

Multiparametric molecular characterization of pulmonary sarcomatoid carcinoma reveals a nonrandom amplification of anaplastic lymphoma kinase (ALK) gene
Abstract: Background: Genetic alterations for targeting therapy are largely unexplored issues in pulmonary sarcomatoid carcinoma (PSC), a life-threatening tumor subset.Methods: EGFR, HER2, KRAS, p53, CTNNB1, BRAF and PIK3CA mutations were assessed by direct sequencing, ALK, EGFR and HER2 gene status by fluorescence in situ hybridization (FISH), and ALK protein expression by immunohistochemistry (IHC) in 20 pleomorphic carcinomas (PLC), two pulmonary blastomas (PB) and one carcinosarcoma (CS). Surgical specimens and, in case of positivity, the corresponding preoperative biopsies were analyzed. Furthermore, 51 consecutive me...
Source: Lung Cancer - June 18, 2012 Category: Cancer & Oncology Authors: Giuseppe Pelosi, Patrizia Gasparini, Alberto Cavazza, Giulio Rossi, Paolo Graziano, Mattia Barbareschi, Federica Perrone, Massimo Barberis, Masayuki Takagi, Toshiaki Kunimura, Tetsuya Yamada, Yukio Nakatani, Ugo Pastorino, Paolo Scanagatta, Gabriella Sozz Tags: Diagnosis and pathology Source Type: research

Current concepts in the imaging of uterine sarcoma
Abstract Recent advances in genetics and pathology have improved our understanding of diagnosis and staging of uterine sarcomas. The major types of uterine sarcomas include leiomyosarcoma, low-grade endometrial stromal sarcoma, undifferentiated endometrial sarcoma, adenosarcoma and carcinosarcoma. The distinctive biological behavior and poor overall survival of uterine sarcoma create challenges in the management of these tumors. We herein present a comprehensive review of taxonomy, epidemiology, pathology, imaging findings and natural history of a wide spectrum of uterine sarcomas. Content Type Journal ...
Source: Abdominal Imaging - June 15, 2012 Category: Radiology Tags: Abdominal Imaging Source Type: research

Use of mutation profiles to refine the classification of endometrial carcinomas
AbstractThe classification of endometrial carcinomas is based on pathological assessment of tumour cell type; the different cell types (endometrioid, serous, carcinosarcoma, mixed, undifferentiated and clear cell) are associated with distinct molecular alterations. This current classification system for high‐grade subtypes, in particular the distinction between high‐grade endometrioid (EEC‐3) and serous carcinomas (ESC), is limited in its reproducibility and prognostic abilities. Therefore, a search for specific molecular classifiers to improve endometrial carcinoma subclassification is warranted. We performed target...
Source: The Journal of Pathology - May 31, 2012 Category: Pathology Authors: Melissa K McConechy, Jiarui Ding, Maggie CU Cheang, Kimberly Wiegand, Janine Senz, Alicia Tone, Winnie Yang, Leah Prentice, Kane Tse, Thomas Zeng, Helen McDonald, Amy P. Schmidt, David G. Mutch, Jessica N McAlpine, Martin Hirst, Sohrab P Shah, Cheng‐Han Tags: Original Paper Source Type: research

Pulmonary carcinosarcoma with an osteosarcomatous component
We report a case of a potentially curative resection for carcinosarcoma with an osteosarcoma component. Thoracic surgeons should be aware of this rare tumor when lung tumors with ossification are encountered. Content Type Journal ArticleCategory Case ReportPages 1-4DOI 10.1007/s11748-012-0098-zAuthors Ryu Kanzaki, Department of General Thoracic Surgery, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habikino, Osaka 583-8588, JapanNaoki Ikeda, Department of General Thoracic Surgery, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, 3-7-1 Habikino, Habiki...
Source: General Thoracic and Cardiovascular Surgery - May 25, 2012 Category: Cardiovascular & Thoracic Surgery Tags: General Thoracic and Cardiovascular Surgery Source Type: research

Iniparib plus paclitaxel and carboplatin as initial treatment of advanced or recurrent uterine carcinosarcoma: A Gynecologic Oncology Group Study.
CONCLUSIONS: Iniparib plus paclitaxel and carboplatin did not show significant activity to warrant further study. The rate of exclusion upon central pathology review (23%) suggests that review of pathology slides for confirmation of eligibility is important in this tumor type. PMID: 22634397 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 24, 2012 Category: Cancer & Oncology Authors: Aghajanian C, Sill MW, Secord AA, Powell MA, Steinhoff M Tags: Gynecol Oncol Source Type: research

Carcinosarcoma of the parotid gland featuring foci of malignant giant cell tumor
In this study, we describe the case of an 81-year-old male patient with parotid gland carcinosarcoma featuring foci of undifferentiated carcinoma and sarcomatous components such as chondrosarcoma, high-grade undifferentiated sarcoma, and malignant giant cell tumor. We reviewed and discussed this rare occurrence of salivary gland carcinosarcoma with areas of malignant giant cell tumor, which had been reported only twice previously.O carcinossarcoma de glândulas salivares é uma neoplasia rara na qual os componentes epitelial e estromal apresentam critérios microscópicos de malignidade. Setenta e quatro casos já foram re...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 18, 2012 Category: Pathology Source Type: research

A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study
Conclusion: Toremifene may be a valid and safe alternative to tamoxifen in premenopausal women with endocrine-responsive breast cancer. (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2012 Category: Cancer & Oncology Authors: Fengxi SuRan GuWeijuan JiaYunjie ZengNanyan RaoYue HuShunrong LiJiannan WuLiang JinLijuan ChenErwei SongMeijun LongKai ChenQiaozhen XiaoMei WuLili Chen Source Type: research

Diagnosis and Management of Multiple Carcinosarcoma of the Breast in a Young Chinese Patient
Breast Care 2012;7:147–149 (DOI:10.1159/000337772) (Source: Breast Care : Last 20 articles)
Source: Breast Care : Last 20 articles - April 23, 2012 Category: Cancer & Oncology Source Type: research

Squamotous-type sarcomatoid carcinoma of the lung with rhabdomyosarcomatous components
In this study, we describe a unique case of a 43-year-old man with a 75 packet/year smoking history in whom a rare mixed malignant tumor of the lung was diagnosed and treated by left pneumonectomy. Histological examination of the resected specimen showed squamous cell carcinoma and rhabdomyosarcoma components. Although rare, the association of a sarcomatoid carcinoma of the lung with squamous cell carcinoma and rhabdomyosarcomatous component is possible and should be kept in mind when dealing with these unusual tumors. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - April 19, 2012 Category: Cancer & Oncology Authors: Figen TurkGokhan YuncuFerda BirGokhan OzturkYasin Ekinci Source Type: research

Epithelial to mesenchymal transition in the pathogenesis of uterine malignant mixed Müllerian tumours: the role of ubiquitin proteasome system and therapeutic opportunities
Abstract Malignant mixed Müllerian tumours (malignant mixed mesodermal tumours, MMMT) of the uterus are metaplastic carcinomas with a sarcomatous component and thus they are also called carcinosarcomas. It has now been accepted that the sarcomatous component is derived from epithelial elements that have undergone metaplasia. The process that produces this metaplasia is epithelial to mesenchymal transition (EMT), which has recently been described as a neoplasia-associated programme shared with embryonic development and enabling neoplastic cells to move and metastasise. The ubiquitin proteasome system (UPS) r...
Source: Clinical and Translational Oncology - April 16, 2012 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: research

High level of Ets‐related gene expression has high specificity for prostate cancer: a tissue microarray study of 11 483 cancers
Conclusions: The high specificity of ERG expression in both normal and neoplastic tissues suggests a very narrow biological role for ERG in highly selected tissues. (Source: Histopathology)
Source: Histopathology - March 28, 2012 Category: Pathology Authors: Sarah Minner, Andreas M Luebke, Martina Kluth, Carsten Bokemeyer, Fritz Jänicke, Jakob Izbicki, Thorsten Schlomm, Guido Sauter, Waldemar Wilczak Source Type: research

Carcinosarcoma of the gallbladder: report of two cases
Abstract Adenocarcinoma is the predominant histological type of carcinoma of the gallbladder, accounting for more than 80% of all gallbladder carcinomas. In contrast, carcinosarcoma of the gallbladder is an extremely atypical subset of gallbladder malignancies. It is characterized by the presence of both epithelial and mesenchymal components. Currently, fewer than 100 cases have been reported in the English literature. Therefore, knowledge and experience regarding this disease are limited. Recently, we experienced two cases of gallbladder carcinosarcoma, which were diagnosed as gallbladder carcinoma based on...
Source: Surgery Today - March 6, 2012 Category: Surgery Tags: Surgery Today Source Type: research

Maxillary sarcomatoid carcinoma
A rare maxillary sarcomatoid carcinoma is reported, and the literature is reviewed. Sarcomatoid carcinoma is a high malignant variant of squamous cell carcinoma, also variously known as spindle cell carcinoma pseudosarcoma, carcinosarcoma, sarcomatoid squamous cell carcinoma, pleomorphic carcinoma, and polypoid carcinoma. It comprises a conventional squamous cell carcinoma (SCC) component, and an in situ and/or invasive malignant spindle component with sarcomatous appearance. The diverse nomenclature reflects the uncertain histogenesis of the spindle cell components. (Source: Oral Surgery, Oral Medicine, Oral Pathology, O...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - March 2, 2012 Category: ENT & OMF Authors: Sam Verco, Ian Chambers, Graham Hall Tags: Online Only Articles Source Type: research

Carcinosarcoma of the fallopian tube: Report of four cases and review of literature
Conclusion: Chemotherapy using a platinum drug after surgery seems to be most effective treatment in this disease. (Source: Asia-Pacific Journal of Clinical Oncology)
Source: Asia-Pacific Journal of Clinical Oncology - March 1, 2012 Category: Cancer & Oncology Authors: Yoshihito YOKOYAMA, Megumi YOKOTA, Masayuki FUTAGAMI, Hideki MIZUNUMA Source Type: research

Carcinosarcoma of the ovary: case report and literature review.
Abstract Ovarian carcinosarcoma is a rare and aggressive tumor; patients diagnosed with this cancer are usually given a poor prognosis of under three years. It consists of malignant epithelial and stromal elements. Because this tumor is so rare, the most effective route of chemotherapy has not been determined. We introduce a case of a 54-year-old woman diagnosed with carcinosarcoma of the ovary and review the literature discussing trends of the disease and optimal treatment options. PMID: 22715653 [PubMed - in process] (Source: Tennessee Medicine)
Source: Tennessee Medicine - March 1, 2012 Category: Internal Medicine Authors: Lamb MR, Gertsen E, Middlemas E Tags: Tenn Med Source Type: research

A Rat Pain Model of Facial Cancer
Cancer pain is a very severe problem for patients with advanced or terminal cancer. However, the induction mechanism remains unknown. Orofacial cancer patients often report difficulties in eating and swallowing, different from patients with cancer in other regions. Although several cancer pain animal models have been reported, these models have focused on the sciatic nerve areas. To understand the mechanisms of pain associated with orofacial cancer, we recently created a rat facial cancer model by inoculation of cancer cells into the vibrissal pad. This model provides mechanical allodynia, thermal hyperalgesia, and feeding...
Source: Springer protocols feed by Molecular Medicine - February 18, 2012 Category: Molecular Biology Source Type: news

Carcinosarcoma of the Gallbladder Manifesting as Cholangitis Due to Hemobilia
Conclusion Preoperative computed tomography and magnetic resonance imaging indicated the cause of cholangitis and provided qualitative information regarding the two components of the tumor. Content Type Journal ArticleCategory GI ImagePages 1-4DOI 10.1007/s11605-012-1836-3Authors Hiroshi Sadamori, Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Okayama, 700-8558 JapanHiroyasu Fujiwara, Department of Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shi...
Source: Journal of Gastrointestinal Surgery - February 15, 2012 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: research

Malignant Transformation in Mature Cystic Teratoma of the Ovary: Three Cases Mimicking Primary Ovarian Epithelial Tumors
This study reports 3 unusual cases of malignant transformation in mature cystic teratoma of the ovary (dermoid cyst), namely carcinosarcoma, atypical choroid plexus papilloma, and papillary thyroid carcinoma, the last case involving both ovaries and with peritoneal dissemination. Adequate sampling is essential in such ovarian tumors to establish their teratomatous origin and avoid an erroneous diagnosis of primary ovarian or metastatic tumors. The authors present the clinicopathological findings in these 3 cases with a review of literature. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - February 15, 2012 Category: Pathology Authors: Quadri, A. M., Ganesan, R., Hock, Y. L., Karim, S. N., Hirschowitz, L. Tags: Original Articles Source Type: research