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The Role of Pelvic and/or Para-Aortic Lymphadenectomy in Surgical Management of Apparently Early Carcinosarcoma of UterusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pelvic and para-aortic lymphadenectomy should be performed in patients with apparently early carcinosarcoma of the uterus, especially in those with myometrial invasion >1/2 or LVSI. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1245/s10434-009-0833-6Authors Jeong-Yeol Park, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, College of Medicine Seoul KoreaDae-Yeon Kim, University of Ulsan, Asan Medical Center Department of Obstetrics and Gynecology, College of Medicine Seoul KoreaJong-Hyeok Kim, University of Ulsan, Asan Medical Center...
Source: Annals of Surgical Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

How to deal with prognostic factors and radiotherapy results in uterine neoplasms with a sarcomatous component?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Uterine tumours with a sarcomatous component have a poor outcome in spite of treatment in comparison to endometrial carcinoma, probably due to the higher frequency of adverse prognostic factors. In early stages tumour size was the most determining factor for OS, DFS, LRFS and DMFS. Radiotherapy significantly improved these survivals in advanced cases. Content Type Journal ArticleCategory Research ArticlesDOI 10.1007/s12094-009-0424-9Authors Ángeles Rovirosa, Hospital Clínic i Universitari Radiation Oncology Department ICMHO, IDIBAPS C/Villarroel, 170 ES-08036 Barcelona SpainCarlos Ascaso...
Source: Clinical and Translational Oncology - November 18, 2009 Category: Cancer & Oncology Tags: Clinical and Translational Oncology Source Type: journals

Scientists Release New Data On Endometrial Cancer TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current study results from the report, 'A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma,' have been published. According to a study from the United Kingdom, Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 17, 2009 Category: Cancer & Oncology Source Type: news

A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This regimen is generally well tolerated with encouraging efficacy. (Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Ang, J. E., Shah, R. N., Everard, M., Keyzor, C., Coombes, I., Jenkins, A., Thomas, K., A'Hern, R., Jones, R. L., Blake, P., Gabra, H., Hall, G., Gore, M. E., Kaye, S. B. Tags: gynecologic tumors Source Type: journals

Surgical outcome of carcinosarcoma of the gall bladder: A review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carcinosarcoma, which comprises less than one percent of all gall bladder neoplasms, is characterized by the presence of variable proportions of carcinomatous and sarcomatous elements. Recently, several reports have described patients suffering from carcinosarcoma of the gall bladder. However, there are no large studies regarding the clinicopathologic features, therapeutic management, and surgical outcome of this disease because the number of patients who undergo resection of gall bladder carcinosarcoma at a single institution is limited. A Medline search was performed using the keywords 'gall bladder' and 'carcinosarc...
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Okabayashi T, Sun ZL, Montgomey RA, Hanazaki K Tags: World J Gastroenterol Source Type: journals

Pulmonary carcinosarcoma masquerading as a cryptic disseminated malignancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case which presented with unusual clinical features and proved cryptic until death. At autopsy, it was a stage IV lung malignancy and histopathology revealed a carcinosarcoma comprising an adenocarcinoma and an osteosarcoma with metastasis to the heart, lymph nodes, and both adrenals. To our knowledge, this is the first case of this subtype with metastasis to the heart. The present case had an unusual clinical presentation and its elusive nature towards diagnosis despite dissemination is noteworthy and unique in the literature. PMID: 19805960 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Kaur A, Falleiro JJ, Ghosh AK, Mani NS Tags: Indian J Pathol Microbiol Source Type: journals

Hepatic carcinosarcoma demonstrated by Ga-67 scintigraphyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A case of a primary hepatic carcinosarcoma, a very uncommon liver tumor in adults, demonstrated by Ga-67 scintigraphy, was reported. The liver image showed a lesion of low activity in the left lobe of the liver, whereas the Ga-67 image showed a moderate accumulation in the lesion detected by the liver scan and further indicated a high accumulation extending downwards from the hepatic lesion. An autopsy revealed that the huge abdominal tumor was composed of hepatocellular carcinoma and malignant mesenchymoma in the left hepatic lobe and in the lower part of the tumor, respectively. The Ga-67 image de...
Source: Annals of Nuclear Medicine - September 29, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Carcinosarcoma of the duodenum: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of carcinosarcoma of the duodenum. Carcinosarcoma of the duodenum is a very rare tumor. A 72-year-old man was referred to the hospital because of appetite loss. Endoscopy demonstrated an irregularly depressed lesion (type 3) in the descending portion of the duodenum opposite to the ampulla of Vater. Computed tomography showed a thickened duodenal wall and swelling of the abdominal para-aortic lymph nodes. A biopsy specimen revealed a well-differentiated adenocarcinoma. A diagnosis of duodenal carcinoma was made (cT3, cN1, cM1, cStage IV according to the TNM classification). A subtotal stoma...
Source: Surgery Today - September 29, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Carcinosarcoma of the Ovary: A Review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 673DOI: 10.1097/OGX.0b013e3181b8aff3Authors: Cantrell, Leigh A. MD, MSPH *; Van Le, Linda MD + (Source: Obstetrical & Gynecological Survey)
Source: Obstetrical & Gynecological Survey - September 24, 2009 Category: OBGYN Tags: Abstract HTML PDF (858 K) Source Type: journals

Carcinosarcoma of the breast: report of a case and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a female patient with breast CS. Relevant literature is briefly reviewed. A 65-year-old-woman was admitted for the management of a palpable mass of the left breast. Mammography depicted a high-density mass with marginal irregularity and pleomorphic calcification. Subsequent excisional biopsy revealed a biphasic metaplastic breast carcinoma, and the patient underwent a left-modified radical mastectomy. The final histopathologic diagnosis was defined as a metaplastic breast carcinoma of CS type, with a squamous cell epithelial component of intermediate and mainly low-grade differentiation. Recent case series ...
Source: Gynecological Surgery - September 16, 2009 Category: OBGYN Tags: Gynecological Surgery Source Type: journals

Therapeutic effectiveness of chemoradiotherapy for carcinosarcoma of the esophagus: two case reports and a review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report two patients with carcinosarcoma of the esophagus who received neoadjuvant chemoradiotherapy and underwent curative resection. Patient 1 was a 50-year-old man with a type 2 lesion in the upper thoracic esophagus; clinical stage was T3 or partial T4N1M0. After chemoradiotherapy the tumor and the lymph nodes become smaller, and subtotal esophagectomy was performed. Patient 2 was a 66-year-old man with a protruding lesion in the lower thoracic esophagus. Preoperative chemoradiotherapy was administered, and he had a partial response. However, surgery was postponed because of pneumonia; 11 months later, tumor enl...
Source: Esophagus - September 15, 2009 Category: Gastroenterology Tags: Esophagus Source Type: journals

An intracapsular carcinoma ex pleomorphic adenoma with lung metastases composed exclusively of benign elements: Histological evidence of a continuum between metastasizing pleomorphic adenoma and carcinoma ex pleomorphic adenoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the case of a 62-year-old female with an intracapsular ca ex PA of the buccal mucosa with subsequent metastases to the lung. The metastatic deposits resembled benign PA with no histological evidence of malignancy. This pattern of spread is described with mPA, an entity that caused controversy in the past regarding its exact classification as a benign or malignant tumor. The possibility that ca ex PA originates from a mPA, with intracapsular ca ex PA representing an intermediate lesion in a histological continuum, is discussed. PMID: 19665316 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)
Source: Pathology, Research and Practice - August 5, 2009 Category: Pathology Authors: Weissferdt A, Langman G Tags: Pathol Res Pract Source Type: journals

Endoscopic polypectomy: a promising therapeutic choice for esophageal carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophageal carcinosarcoma is a rare malignant tumor composing of both carcinomatous and sarcomatous elements. Endoscopic therapy is less invasive and may represent an alternative to esophagectomy for superficial esophageal carcinosarcoma. Here, we report a 61-year-old male who was diagnosed as esophageal carcinosarcoma and underwent endoscopic polypectomy with well tolerance and favorable prognosis. We also present a brief review of the literature. PMID: 19610152 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 20, 2009 Category: Gastroenterology Authors: Ji F, Xu YM, Xu CF Tags: World J Gastroenterol Source Type: journals

Carcinosarcoma of the Prostate Replacing the Entire Lower Genitourinary TractEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Less than 100 cases of prostate carcinosarcoma have been described in published studies. Most of these cases describe symptoms due to bladder outlet obstruction that typically results in transurethral resection of the prostate. Our patient presented with tenesmus and stranguria due to prostate carcinosarcoma that developed years after being treated with external radiation and androgen deprivation for prostate adenocarcinoma. Because of the patient's escalating symptoms, a pelvic exenteration with creation of urinary and fecal diversions was performed. Despite the dismal survival associated with prostate carcinosarcoma, pal...
Source: Urology - July 7, 2009 Category: Urology & Nephrology Authors: Shawn M. McGee, Stephen A. Boorjian, R.J. Karnes Tags: Images in Clinical Urology Source Type: journals

Spindle cell sarcoma of larynxEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Spindle cell carcinoma of larynx is rare tumors constituting only 0.6% of laryngeal neoplasm with predominance in elderly males (average 63 yrs). These tumors were described under various names: pseudosarcoma, Carcinosarcoma, fibromyxosarcoma, mixed sarcoma, polypoidal sarcoma. Immunohistochemistry and electron microscopy suggest that spindle cell carcinoma are true neoplasm and spindle cells are part of the neoplasm and not benign reactive fibroblast. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF03050852Authors Sunil Samdhani, SMS Medical College and Hospital Department...
Source: Indian Journal of Otolaryngology and Head & Neck Surgery - July 7, 2009 Category: ENT & OMF Tags: Indian Journal of Otolaryngology and Head & Neck Surgery Source Type: journals

Establishment and characterization of the NEYS cell line derived from carcinosarcoma of human ovary with special reference to the susceptibility test of anticancer drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A cell line designated as NEYS was established from ovarian carcinosarcoma (stage IIIc) of a 56-year-old Japanese woman. The extirpated original tumor was carried in growth medium at 0 °C to the culture room. The primary culture was done on 20 August 2003. The cell line was composed of angular adhesive cells and showed neoplastic and pleomorphic features, such as bizarre aggregation of chromatin granules, an irregular thickening nuclear membrane and multiple large nucleoli. They grew as multi-layered cultures without contact inhibition. The cells proliferated moderately, and population doubling time was about 56 h. The ch...
Source: Human Cell - June 24, 2009 Category: Cytology Authors: Yoshiaki IDE, Taka NAKAHARA, Masanori NASU, Noriko TOMINAGA, Akihiro OHYAMA, Toshiaki TACHIBANA, Makoto YASUDA Source Type: journals

Rapid-growth carcinosarcoma of the esophagus arising from 0-IIc squamous cell carcinoma after definitive chemoradiotherapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A case of carcinosarcoma arising from the area of intraepithelial spread of relapsed esophageal squamous cell carcinoma (SCC) after definitive chemoradiotherapy (CRT) is reported herein. A 71-year-old man was referred to our hospital because of a superficial esophageal carcinoma. Definitive CRT was performed because the patient refused surgical treatment. Complete response was recognized after CRT, but tumor relapse was diagnosed 3 months later. The relapsed tumor initially revealed a minimal depression with a small white nodule. This nodule developed to a sessile elevated mass after 1 month and fin...
Source: Esophagus - June 17, 2009 Category: Gastroenterology Tags: Esophagus Source Type: journals

Malignant neoplasms of the uterus following radiation therapy for cervical carcinoma: a clinical study of 47 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The main uterine neoplasms development after radiation therapy for cervical carcinoma is endometrial carcinomas, of which there is a preponderance of high-risk histological subtypes and a poor prognosis. Most of the uterine sarcomas occurred following radiation therapy for cervical carcinoma are carcinosarcomas and the prognosis is very poor. Content Type Journal ArticleDOI 10.1007/s10330-009-0074-yAuthors Shaokang Ma, Chinese Academy of Medical Sciences Department of Gynecologic Oncology, Caner Hospital, Peking Union Medical College Beijing 100021 ChinaLingying Wu, Chinese Academy of Medic...
Source: The Chinese-German Journal of Clinical Oncology - June 15, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results confirm the antitumor effects of celecoxib in W256 cancer model, contributing to elucidating its antitumoral mechanism and corroborating scientific literature about its effect on other types of cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1031-8Authors Amanda Leite Bastos-Pereira, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilDaiana Lugarini, Federal University of Paraná, Biological Science Sector Department of Pharmacology 81530-990 Curitiba BrazilAdriana de Oliveira-Christof...
Source: Cancer Chemotherapy and Pharmacology - June 9, 2009 Category: Cancer & Oncology Tags: Cancer Chemotherapy and Pharmacology Source Type: journals

Bilateral breast metastasis of lung carcinosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 74-year-old woman presented symptoms of coughing with bloody sputum. A mass obliterating the bronchial segment of the superior lobe of the right lung was defined by thoracic computed tomography (CT) and treated by superior lobectomy. Grossly, a firm mass (7.5cm×6cm) with a heterogeneous cut surface from tan-grey to red was found. The tumor showed a diffuse proliferation of spindle-ovoid cells (vimentin+, S100 focally+) and an irregular glandular architecture (pancytokeratin: AE1&AE3+, EMA+). Desmin, smooth muscle actin (SMA), CD34, surfactant apoprotein A and TTF-1 were negative. The peribronchial lymph nodes were negat...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - June 4, 2009 Category: OBGYN Authors: Metin Akbulut, Canan Kelten, Ferda Bir, Arzu Yaren Tags: Letters to the Editors - Brief Communications Source Type: journals

Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uterine carcinosarcomas (UCSs) are considered to represent true examples of the epithelial-mesenchymal transition. Akt plays a key role in the induction of epithelial-mesenchymal transition, but little is known about its involvement in tumorigenesis. Here we examined the functional roles of the Akt/beta-catenin pathway in UCSs. In clinical samples, phospho-Akt (pAkt) expression was found to be significantly increased in mesenchymal compared with epithelial components, exhibiting both positive and negative correlations with nuclear beta-catenin and E-cadherin, respectively. Expression levels of the transcription factor ...
Source: The American Journal of Pathology - May 31, 2009 Category: Pathology Authors: Saegusa M, Hashimura M, Kuwata T, Okayasu I Tags: Am J Pathol Source Type: journals

Carcinosarcoma in the pouch of DouglasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The present case shows that carcinosarcoma can occur in the pouch of douglas. It may arise from misplaced Mullerian duct remnants in the pouch of douglas. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1132-yAuthors Tadashi Terada, Shizuoka City Shimizu Hospital Department of Pathology Miyakami 1231 Shimizu-Ku Shizuoka 424-8636 Japan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - May 31, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Carcinosarcoma of pancreas with liver metastasis combined with gastrointestinal stromal tumour of the stomach: is there a good prognosis with the complete resection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a carcinosarcoma of the pancreas with liver metastasis combined with gastrointestinal stromal tumour (GIST) of the stomach in a 72-year-old woman who presented with right upper quadrant pain, nausea and vomiting. A radical resection including pancreaticoduodenectomy, left hepatic lobe resection and local resection of the gastric mass was performed. The tumour in the head of pancreas was found to be grossly yellow-white, and it infiltrated the common bile duct and duodenum; the mass of the liver metastasis is solitary. Pathologic examination showed two components separated from each other: one component was a conv...
Source: European Journal of Cancer Care - May 28, 2009 Category: Cancer & Oncology Authors: Z.L. SHEN, S. WANG, Y.J. YE, Y.L. WANG, K.K. SUN, X.D. YANG, K.W. JIANG Source Type: journals

Clinical manifestation of esophageal carcinosarcoma: a Taiwan experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate its clinicopathologic features and endoscopic characteristics. The data of patients diagnosed to have esophageal carcinosarcoma pathologically in the past 30 years (January 1976[ndash]December 2007) were reviewed. Of 3318 cases of esophageal malignancy, 12 were diagnosed as esophageal carcinosarcoma, with an incidence of 0.36%. All of the cases were male with a mean age of 62.3 years. Of the 12 tumors, 8 were polypoid type, and 4 were ulcerative type. In the endoscopic ultrasonography examination, the tumors show heterogeneous hypoechoic lesions with irregular outer margins and internal mult...
Source: Diseases of the Esophagus - May 15, 2009 Category: Gastroenterology Authors: C.-J. Kuo, T.-N. Lin, C.-J. Lin, R.-C. Wu, H.-K. Chang, Y.-Y. Chu, J.-M. Lien, M.-Y. Su, C.-T. Chiu Source Type: journals

Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma - Report of an unusual caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis.Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods.The SCC was typical, but few cells showed a spindle-shaped pattern. The relapse tumor was a spindle-shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm-actin+, desmin+, caldesmon+, vimentin+, keratin-).The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed i...
Source: Head - May 13, 2009 Category: ENT & OMF Authors: Hans-Ullrich Völker, Andreas Zettl, Eugenia Haralambieva, Bernd Blume, Rudolf Hagen, Hans-Konrad Müller-Hermelink, Matthias Scheich Source Type: journals

Miscellaneous Uterine Malignant Neoplasms Detected during Hysteroscopic SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Resectoscopic surgery in women with miscellaneous uterine malignant lesions not adversely affect 5-year survival and long-term prognosis. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - May 1, 2009 Category: OBGYN Authors: George A. Vilos, Fawaz Edris, Basim Abu-Rafea, Jackie Hollett-Caines, Helen C. Ettler, Awatif Al-Mubarak Tags: Original Articles Source Type: journals

Recent progress: gynecologic oncology group trials in uterine corpus tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article will discuss the background and details of each of these important advances. PMID: 19463102 [PubMed - in process] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - April 30, 2009 Category: Cancer & Oncology Authors: King LP, Miller DS Tags: Rev Recent Clin Trials Source Type: journals

[Tamoxifen in the adjuvant setting for breast cancer: Reflexions about the risk of uterine carcinosarcoma]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A descriptive analysis of available data on reported cases of uterine carcinosarcomas associated with tamoxifen therapy is undertaken. The role of aromatase inhibitors as alternative to tamoxifen therapy in the adjuvant setting of breast cancer is discussed. The eventual implications of the presumed association of uterine carcinosarcoma and tamoxifen therapy on the choice of the therapeutic agent in the adjuvant setting of hormone-sensitive breast cancer are discussed. PMID: 19394886 [PubMed - in process] (Source: Gynecologie, Obstetrique & Fertilite)
Source: Gynecologie, Obstetrique & Fertilite - April 30, 2009 Category: OBGYN Authors: Leung F, Terzibachian JJ, Govyadovskiy A, Bourtembourg A, Maillet R, Riethmuller D Tags: Gynecol Obstet Fertil Source Type: journals

Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesotheliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules. He had been operated 2 years before for a pleomorphic adenoma of the parotid and had a healthy scar at that site. FNAC from the pleural lesions showed myxoid background substance with entrapped cuboidal epithelial cells with atypical nuclei, which were interpreted as mesothelial cells. These cells in contrast to the usual mesothelial cells were...
Source: Diagnostic Cytopathology - April 16, 2009 Category: Pathology Authors: Prashant Khadse, Kumar Prabhash, C. S. Pramesh, Pankaj Chaturvedi, Tanuja Shet Source Type: journals

Treatment of early uterine sarcomas: disentangling adjuvant modalitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Uterine sarcomas are a rare group of neoplasms with aggressive clinical course and poor prognosis. They are classified into four main histological subtypes in order of decreasing incidence: carcinosarcomas, leiomyosarcomas, endometrial stromal sarcomas and "other" sarcomas. The pathological subtype demands a tailored approach. Surgical resection is regarded as the mainstay of treatment. Total abdominal hysterectomy and bilateral salpingo-oophorectomy represents the standard treatment of uterine sarcomas. Pelvic and para-aortic lymph node dissection in carcinosarcomas is recommended, given their high incidence of lymph node...
Source: BioMed Central - April 8, 2009 Category: Journals (General) Authors: Flora Zagouri, Athanasios-Meletios Dimopoulos, Stelios Fotiou, Vassilios Kouloulias and Christos A. Papadimitriou Source Type: journals

Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of 78-year-old woman histopathologically diagnosed after surgery. Macroscopically, the tumor was a dark-greenish solid mass with a short stalk, filling the gallbladder cavity, and it measured 11.5 × 4.0 × 3.5 cm in diameter. Microscopically, the tumor was composed of abundant loose stroma and a glandular component. Some of the glandular cells had hyperchromatic nuclei with disturbed polarity and were positively stained by p53 (30%) and Ki-67 (30–40%). Part of the stromal component revealed hypercellularity with an irregular nucleus, mitosis (2–3 cells/10 high-power fields...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - April 7, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report exemplifies that even very uncommon breast tumor types may develop through biallelic inactivation of BRCA1 gene, that has to be considered in the genetic testing settings. PMID: 19350356 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 6, 2009 Category: Cancer & Oncology Authors: Suspitsin EN, Sokolenko AP, Voskresenskiy DA, Ivantsov AO, Shelehova KV, Klimashevskiy VF, Matsko DE, Semiglazov VF, Imyanitov EN Tags: Breast Cancer Source Type: journals

Carcinosarcoma of the gallbladder.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carcinosarcoma of the gallbladder is an uncommon neoplasm. We herein report the case of a patient with carcinosarcoma of the gallbladder, treated by simple cholecystectomy for a tumor which was confined to the gallbladder. PMID: 19332928 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 1, 2009 Category: Pathology Authors: Agarwal T, Jain M, Goel A, Visayaragavan P, Gupta RK Tags: Indian J Pathol Microbiol Source Type: journals

Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 23 cases of tumors of the salivary gland comprising 18 cases of carcinoma ex pleomorphic adenoma, four cases of carcinosarcoma of the parotid and one case of benign metastasizing pleomorphic adenoma. The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. PMID: 19332899 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 1, 2009 Category: Pathology Authors: Qureshi A, Barakzai A, Sahar NU, Gulzar R, Ahmad Z, Hassan SH Tags: Indian J Pathol Microbiol Source Type: journals

Carcinosarcoma of the colon: a rare cause of colovesical fistula.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carcinosarcomas are relatively rare tumors composed of both carcinomatous and sarcomatous components. The most common sites involved by this tumor are the head and neck, respiratory tract, uterus, ovaries, and fallopian tubes. Within the gastrointestinal tract this tumor most often occurs in the esophagus, followed by the stomach. Carcinosarcomas are very aggressive tumors associated with a poor prognosis. The first case of carcinosarcoma of the colon was reported in 1986. The case reported here is the only one involving an associated colovesical fistula. PMID: 19385296 [PubMed - indexed for MEDLINE] (Source: The American Surgeon)
Source: The American Surgeon - March 31, 2009 Category: Surgery Authors: Patel DH, Dang S, Bentley FR, Julka RN, Olden KW, Aduli F Tags: Am Surg Source Type: journals

Carcinosarcoma of the gallbladder producing α-fetoprotein and manifesting as leukocytosis with elevated serum granulocyte colony-stimulating factor: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A 69-year-old man was referred to our hospital for investigation of leukocytosis and a persistent fever of 38°C, but we could find no evidence of a specific infection. The leukocyte count was 18 000/mm3, and the serum granulocyte colony-stimulating factor (G-CSF) and α-fetoprotein (AFP) levels were both elevated, at 66.3 pg/ml and 1,495 ng/ml, respectively. Computed tomography (CT) showed a gallbladder tumor and we performed extended cholecystectomy. Postoperatively, the fever subsided and the leukocyte count, serum G-CSF and AFP level normalized. Histologically, the tumor was a carcinosarcoma of ...
Source: Surgery Today - March 12, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We suppose that the similar proportion of p53 overexpression in both the epithelial and mesenchymal components may be one of the findings explaining the histogenesis of this tumor by combination theory. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1017-0Authors Kyuichi Kadota, University Hospital, Kagawa University Department of Diagnostic Pathology, Faculty of Medicine 1750-1, Ikenobe Miki-cho Kagawa 761-0793 JapanReiji Haba, University Hospital, Kagawa University Department of Diagnostic Pathology, Faculty of Medicine 1750-1, Ikenobe Miki-cho Kagawa 761-0793 Japan...
Source: Archives of Gynecology and Obstetrics - March 5, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Inflammatory myofibroblastic tumour of the urinary bladder mimicking recurrent uterine carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19309402 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - March 1, 2009 Category: Pathology Authors: Pristauz G, Moinfar F, Chromecki T, Bader AA, Winter R, Tamussino K Tags: Histopathology Source Type: journals

Differential expression of topoisomerase II alpha protein in salivary gland carcinomas: histogenetic and prognostic implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Salivary gland carcinomas are relatively uncommon heterogeneous malignancies characterized by locoregional invasion and distant metastasis. Topoisomerase II alpha (topoII alpha), located at chromosome 17q21-22, is considered a major mediator of cell proliferation and DNA replication. The purpose of this study was to evaluate the expression of topoII in various types of salivary gland tumors and its biological significance. Methods: The protein expression of topoII alpha was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 ple...
Source: BMC Cancer - February 27, 2009 Category: Cancer & Oncology Authors: Shin-ichiro Maruya, Takashi Shirasaki, Takahiko Nagaki, Seiji Kakehata, Hidekachi Kurotaki, Hiroki Mizukami and Hideichi Shinkawa Source Type: journals

Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reports.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 31 (Source: Reactions Weekly)
Source: Reactions Weekly - February 15, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Tamoxifen: Uterine carcinosarcoma in elderly patients: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 15, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Carcinosarcoma of the gallbladder: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a 70-year-old male patient who was diagnosed by documenting the epithelial and mesenchymal components with histopathological and immunohistochemical methods, and treated by a radical cholecystectomy. The pediculated polypoid tumor had filled the lumen, originating from the gallbladder fundus. The tumor infiltrated the surrounding connective and adipose tissue overlapping the muscular layer of its primary site, but had not perforated the serosa nor invaded the liver. The patient, who was treated only surgically, has remained healthy after 54 months of follow-up, which is the longest documented sur...
Source: Surgery Today - February 7, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Evaluation of prognostic factors and treatment outcomes in uterine carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The poor outcome for these patients may reflect the aggressive nature of carcinosarcoma and that at the time of presentation more than 50% have extra-uterine disease, which was associated with significant poorer survival. Systemic adjuvant therapy has not been associated with significant improvement in the outcome. More studies are needed to better define the appropriate treatment for this rare cancer. PMID: 19201517 [PubMed - as supplied by publisher] (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 6, 2009 Category: OBGYN Authors: Galaal K, Kew FM, Tam KF, Lopes A, Meirovitz M, Naik R, Godfrey KA, Hatem MH, Edmondson RJ Tags: Eur J Obstet Gynecol Reprod Biol Source Type: journals

Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In uterine carcinosarcoma, estrogen receptor beta expression is elevated and increases with disease progression, whereas estrogen receptor alpha and progesterone receptor are suppressed. Human epidermal growth factor receptor 2 expression is increased, whereas insulin-like growth factor receptor is lower than in normal endometrium. These data support a potential role for estrogen receptor beta in disease progression via crosstalk with human epidermal growth factor receptor 2. PMID: 19200930 [PubMed - as supplied by publisher] (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 5, 2009 Category: OBGYN Authors: Huang GS, Arend RC, Li M, Gunter MJ, Chiu LG, Horwitz SB, Goldberg GL Tags: Am J Obstet Gynecol Source Type: journals

P63 is a helpful tool in the diagnosis of a primary cutaneous carcinosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19208080 [PubMed - in process] (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 1, 2009 Category: Pathology Authors: Romanelli P, Miteva M, Schwartzfarb E, Ricotti C, Sullivan T, Abenoza P, Nadji M Tags: J Cutan Pathol Source Type: journals

Endometrial stromal sarcomas with extensive endometrioid glandular differentiation: report of a series with emphasis on the potential for misdiagnosis and discussion of the differential diagnosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Endometrial stromal sarcoma with extensive endometrioid glandular differentiation is rare. The presence of glands often results in diagnostic difficulty with a significant risk of misdiagnosis or delay in diagnosis. It is likely that some cases reported in the literature as aggressive endometriosis represent this entity. PMID: 19236513 [PubMed - in process] (Source: Histopathology)
Source: Histopathology - February 1, 2009 Category: Pathology Authors: McCluggage WG, Ganesan R, Herrington CS Tags: Histopathology Source Type: journals

A True Pulmonary Carcinosarcoma that Required Diagnostic Differentiation from a Pleomorphic Adenoma: A Case Report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary carcinosarcoma is a rarely encountered tumor. We treated a patient who had an intrabronchial polypoid lesion that required a diagnostic differentiation from epithelial-mesenchymal mixed neoplasms inclusive of pleomorphic adenoma, and that was diagnosed by immunohistochemical staining to be a true carcinosarcoma. A 69-year-old man underwent left pneumonectomy in November 2000 with a diagnosis of atelectasis resulting from a tumor obstructing the left lower lobar bronchus, and also a lung abscess. The tumor was initially diagnosed as pleomorphic adenoma, since it contained both benign-looking epithelial and mes...
Source: Annals of Thoracic and Cardiovascular Surgery - February 1, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Yoshino N, Kubokura H, Yamauchi S, Ohaki Y, Koizumi K, Shimizu K Tags: Ann Thorac Cardiovasc Surg Source Type: journals

A rare case of primary extragenital retroperitoneal carcinosarcoma with review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Carcinosarcomas are rare, highly aggressive neoplasms that most commonly arise from the female genital tract but can unusually present in extragenital locations. To the best of our knowledge, only three cases of primary retroperitoneal, extragenital carcinosarcomas have been documented in the English literature to date. A 72-year-old woman presented with onset of abdominal pain and urinary retention. Computed tomography scan revealed a mass in the retroperitoneal space with hydronephrosis and partial obstruction of the left ureter. Lost to follow-up at that time, the patient returned 6 months l...
Source: Gynecological Surgery - January 15, 2009 Category: OBGYN Tags: Gynecological Surgery Source Type: journals

Primary Carcinosarcoma of the Spleen: Case Report of a Rare Tumor and Review of The LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Carcinosarcoma of extragenital organs is rare. In this article, a case of primary carcinosarcoma of the spleen, which presented as painful splenomegaly is reported. To the best of our knowledge, this is the second reported case of primary splenic carcinosarcoma in English literature. The pathogenesis of these tumors is incompletely understood. No specific treatment guidelines exist for these aggressive tumors, surgery being the mainstay of treatment. The prognosis remains poor regardless of the adjuvant therapy used. (Source: International Journal of Surgical Pathology)
Source: International Journal of Surgical Pathology - January 14, 2009 Category: Pathology Authors: Kochar, K., Vijayasekar, C., Pandey, U., Bhogal, R., Brown, L., Mathew, G. Tags: Article Source Type: journals

Sarcomas associated with hereditary nonpolyposis colorectal cancer: broad anatomical and morphological spectrumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is primarily linked to colorectal and endometrial cancer, but is associated with a broad tumor spectrum. Though not formally part of the syndrome, occasional sarcomas have been reported in individuals with HNPCC. We used the national Danish HNPCC-register to identify HNPCC families in which sarcomas had been diagnosed. Fourteen sarcomas were identified in families with mutations in MSH2, MSH6, and MLH1. The median age at sarcoma diagnosis was 43 (15–74) years. Soft tissue sarcomas predominated followed by uterine sarcomas and eight histopathol...
Source: Familial Cancer - January 8, 2009 Category: Cancer & Oncology Tags: Familial Cancer Source Type: journals