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Identifying The Factors Related To Bile Output And Reduction Of Serum Bilirubin After Percutaneous Transhepatic Biliary DrainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage. A research team, led by Dr. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news

Identifying The Factors Related To Bile Output And Reduction Of Serum Bilirubin After Percutaneous Transhepatic Biliary DrainageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biliary drainage is performed as a palliative treatment of hilar cholangiocarcinoma. The reduction of serum bilirubin is usually the hallmark of successful biliary drainage. However, some patients may have persistent jaundice or scanty bile output after biliary drainage. A research team, led by Dr. (Source: GastroIntestinal News From Medical News Today)
Source: GastroIntestinal News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: GastroIntestinal / Gastroenterology Source Type: news

What relates to the short-term effectiveness of biliary drainage?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(World Journal of Gastroenterology) A research team from Taiwan identified factors that were related to the short term effectiveness of percutaneous transhepatic biliary drainage in cholangiocarcinoma patients and evaluated the impact of palliative drainage on their survival. They found the short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 18, 2009 Category: Global & Universal Source Type: news

Superficially invasive transitional cell carcinoma of the bladder associated with distant cutaneous metastasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cutaneous metastases from transitional cell carcinoma of the bladder are rare and most often associated with a deeply invasive primary tumor. This case report describes a 69-year-old male with previously resected superficially invasive primary transitional cell carcinoma of the bladder who presented with distant cutaneous and central nervous system metastases associated with recurrent bladder cancer. In addition, this case highlights the differential diagnosis of metastatic carcinomas that display a CK7/CK20 positive immunophenotype including transitional cell carcinoma, pancreatic carcinoma, cholangiocarcinoma and rare ga...
Source: Journal of Cutaneous Pathology - November 16, 2009 Category: Pathology Authors: Brian L. Swick, Jennifer R.S. Gordon Source Type: journals

Diffusion-weighted MR imaging of liver on 3.0-Tesla system: effect of intravenous administration of gadoxetic acid disodiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion DWI after Gd-EOB-DTPA administration can be used as a substitute for unenhanced DWI at 3.0 T without compromising CNR and ADC of focal hepatic lesions. Content Type Journal ArticleCategory Hepatobiliary-PancreasDOI 10.1007/s00330-009-1651-8Authors Ji Soo Choi, Yonsei University College of Medicine Department of Radiology, Severance Hospital and Research Institute of Radiological Science Seoul KoreaMyeong-Jin Kim, Yonsei University College of Medicine Department of Radiology, Severance Hospital and Research Institute of Radiological Science Seoul KoreaJin-Young Choi, Yonsei University College...
Source: European Radiology - November 14, 2009 Category: Radiology Tags: European Radiology Source Type: journals

Comorbidity negatively influences prognosis in patients with extrahepatic cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Tumor resection and comorbidity emerged as significant prognostic variables in extrahepatic cholangiocarcinoma. Comorbidity evaluation instruments should be applied in the clinical management of such patients. PMID: 19908335 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 13, 2009 Category: Gastroenterology Authors: Fernández-Ruiz M, Guerra-Vales JM, Colina-Ruizdelgado F Tags: World J Gastroenterol Source Type: journals

Therapeutic effect of photodynamic therapy using hematoporphyrin monomethyl ether (HMME) on human cholangiocarcinoma cell line QBC939.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the effect of PDT using HMME as the photosensitizer, and the 630nm diode laser on human cholangiocarcinoma cell line QBC939. Cell viability was determined by MTT assay. The percentage of apoptotic cell was determined by flow cytometry following annexin V/PI staining. Two methods were used for the determination of apoptosis: terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling assay and laser scanning confocal microscope detection. The procaspase-3 and cytochrome cwere measured by western blot. In vitro PDT showed excellent cytotoxicity that was afunction of laser energy and drug concentra...
Source: Neoplasma - November 11, 2009 Category: Cancer & Oncology Authors: Wang JB, Liu LX, Pan SH, Wang CY, Fu QF Tags: Neoplasma Source Type: journals

Surgical Management of Infrahilar/Suprapancreatic Cholangiocarcinoma: an Analysis of the Surgical Procedures, Surgical Margins, and Survivals of 77 PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Perineural invasion, rather than the type of surgical procedure, had a significant impact on surgical curability and survival of patients with infrahilar/suprapancreatic cholangiocarcinoma treated according to our intention-to-treat strategy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11605-009-1072-7Authors Yoshihiro Sakamoto, National Cancer Center Hospital Hepatobiliary and Pancreatic Surgery Division 5-1-1 Tsukiji Chuo-ku Tokyo 104-0045 JapanKazuaki Shimada, National Cancer Center Hospital Hepatobiliary and Pancreatic Surgery Division 5-1-1 Tsukiji Chuo-ku Tokyo 10...
Source: Journal of Gastrointestinal Surgery - November 10, 2009 Category: Surgery Tags: Journal of Gastrointestinal Surgery Source Type: journals

A case of advanced intrahepatic cholangiocarcinoma successfully treated with chemosensitivity test-guided systemic chemotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intrahepatic cholangiocarcinoma (ICC) is a relatively rare and highly fatal neoplasm that arises from the biliary epithelium. Prognosis is generally poor and survival is limited to a few months. Here we present a case of advanced ICC successfully treated by chemosensitivity test-guided systemic chemotherapy combining S-1 and cisplatin (CDDP). A 65-year-old woman with a liver tumor was referred to our hospital on November 21, 2007. Abdominal ultrasonography and computed tomography (CT) showed low-density masses of 50 and 15 mm in diameter, respectively in segment VIII of the liver and in the enlarged lymph node in the p...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Abe K, Wakatsuki T, Katsushima F, Monoe K, Kanno Y, Takahashi A, Yokokawa J, Ohira H Tags: World J Gastroenterol Source Type: journals

Biloma: an unusual complication in a patient with pancreatic cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 64-year-old man initially diagnosed with a non-obstructive malignancy of the pancreas, who developed a spontaneous intrahepatic biloma 8 mo later. This was identified following a 1-wk history of fever, rigors and icterus. The biloma was identified on computed tomography and subsequently drained under ultrasound guidance. Forty-eight hours later, a stent was inserted endoscopically into his common bile duct and he made an uneventful in-hospital recovery. We believe this is the first documented case of spontaneous intrahepatic biloma to occur secondary to pancreatic malignancy. PMID: 19891023 [Pub...
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Trivedi PJ, Gupta P, Phillips-Hughes J, Ellis A Tags: World J Gastroenterol Source Type: journals

Factors relating to the short term effectiveness of percutaneous biliary drainage for hilar cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The short term effectiveness of percutaneous biliary drainage was related to patient's prothrombin time or the extent of tumor involvement. It, however, had no impact on survival. PMID: 19891021 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 7, 2009 Category: Gastroenterology Authors: Tsai HM, Chuang CH, Lin XZ, Chen CY Tags: World J Gastroenterol Source Type: journals

Microsatellite loci in the carcinogenic liver fluke, opisthorchis viverrini and their application as population genetic markers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MICROSATELLITE LOCI IN THE CARCINOGENIC LIVER FLUKE, OPISTHORCHIS VIVERRINI AND THEIR APPLICATION AS POPULATION GENETIC MARKERS. Infect Genet Evol. 2009 Nov 6; Authors: Laoprom N, Sithithaworn P, Ando K, Sithithaworn J, Wongkham S, Laha T, Klinbunga S, Webster JP, Andrews RH Opisthorchis viverrini is a carcinogenic foodborne trematode endemic in Southeast Asia especially in Thailand and the Lao People's Democratic Republic. Opisthorchiasis causes hepatobiliary diseases and cholangiocarcinoma (bile duct cancer). Currently there is substantial evidence on genetic variation of O.viverrini but the information on po...
Source: Infection, Genetics and Evolution - November 6, 2009 Category: Genetics & Stem Cells Authors: Laoprom N, Sithithaworn P, Ando K, Sithithaworn J, Wongkham S, Laha T, Klinbunga S, Webster JP, Andrews RH Tags: Infect Genet Evol Source Type: journals

Elevating Blood Pressure as a Strategy to Increase Tumor-targeted Delivery of Macromolecular Drug SMANCS: Cases of Advanced Solid TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study is to evaluate the improved method of arterial infusion therapy of SMANCS (SX) with lipiodol under the angiotensin-induced hypertensive state for various difficult-to-treat solid tumors. Most patients were unresectable with no other therapeutic options, recurrence after resection, or patients do not respond to common treatments. The new method utilizes angiotensin II (AT) to induce hypertension (e.g. ~15–30 mmHg above norm) for 15–20 min. This method was successfully applied to metastatic liver cancer, cholangiocarcinoma, massive renal cell carcinoma, pancreatic and other abdominal sol...
Source: Japanese Journal of Clinical Oncology - November 2, 2009 Category: Cancer & Oncology Authors: Nagamitsu, A., Greish, K., Maeda, H. Tags: Case Reports Source Type: journals

Rapid molecular detection of Opisthorchis viverrini in human fecal samples by real-time polymerase chain reaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the development of a real-time FRET PCR for molecular detection of Opisthorchis viverrini in human fecal samples. The diagnostic sensitivity, specificity, accuracy, and positive and negative predictive values of this method were 97.5%, 100%, 98.9%, 100%, and 98.2%, respectively. The sensitivity was not significantly different from that of the quantified formalin-ethyl acetate concentration technique, the gold standard (P > 0.05). The procedure has potential for diagnosis of human opisthorchiasis in disease-endemic areas, for large epidemiologic investigations involving at risk populations, and monitoring eradi...
Source: The American Journal of Tropical Medicine and Hygiene - October 31, 2009 Category: Tropical Medicine Authors: Intapan PM, Thanchomnang T, Lulitanond V, Pongsaskulchoti P, Maleewong W Tags: Am J Trop Med Hyg Source Type: journals

Yttrium-90 Radiotherapy for Unresectable Intrahepatic Cholangiocarcinoma: A Preliminary Assessment of This Novel Treatment OptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions 90Y radioembolization may be a relatively safe and efficacious treatment for unresectable ICC. In the absence of other effective therapeutic options, this treatment warrants further investigation. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0777-xAuthors Akshat Saxena, University of New South Wales Department of Surgery, St. George Hospital Sydney NSW AustraliaLourens Bester, University of New South Wales Department of Interventional Radiology, St. Vincent’s Hospital Sydney NSW AustraliaTerence C. Chua, University of New South Wales Department of...
Source: Annals of Surgical Oncology - October 30, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Hypercalcemia in a patient with cholangiocarcinoma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Clinicians should be aware of this rare manifestation of CC as prompt and aggressive correction of hypercalcemia alleviates symptoms and improves patient's quality of life, despite the poor overall prognosis. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 30, 2009 Category: Global & Universal Authors: Ioannis XynosStavros SougioultzisAthanasios ZilosKonstantinos EvagellouGregorios Hatzis Source Type: journals

Staining for intracytoplasmic lumina and CAM5.2 increases the detection rate for bile duct cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopy 2009; 41: 965-970DOI: 10.1055/s-0029-1215227 Endoscopic biopsies have a low sensitivity for diagnosing malignant bile duct strictures. Tumor markers detected by mucin staining and immunohistochemistry may help to determine the malignancy of a biopsy specimen where histologic evaluation alone is nondiagnostic.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - October 29, 2009 Category: Gastroenterology Tags: Original article Source Type: journals

Diagnosing and staging bile duct cancer: cholangiographically guided biopsies or cholangioscopy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Endoscopy 2009; 41: 991-992DOI: 10.1055/s-0029-1215230© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Full text (Source: Endoscopy)
Source: Endoscopy - October 29, 2009 Category: Gastroenterology Tags: Editorial Source Type: journals

Unexpected cardiovascular collapse from massive air embolism during endoscopic retrograde cholangiopancreatographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 72 year-old woman with cholangiocarcinoma presented for endoscopic retrograde cholangio pancreatography (ERCP) for diagnostic intraductal endoscopy under GETA. During the technically difficult procedure the patient became suddenly hypoxic, hypotensive, bradycardic, and progressed to PEA code (ETCO2 5 mmHg). ACLS was initiated. Transesophageal echo demonstrated massive right heart air accumulation; abdominal X-Ray showed air filled bile ducts. Central access was obtained, a pulmonary artery catheter floated, and 30 ml of air aspirated from the RV. Within 5 minutes pulses returned; the patient was transferred to the ICU. M...
Source: Acta Anaesthesiologica Scandinavica - October 29, 2009 Category: Anesthesiology Authors: K. M. GOINS, J. M. MAY, C. HUCKLENBRUCH, K. E. LITTLEWOOD, D. S. GROVES Source Type: journals

Extended bile duct resection liver and transplantation in patients with hilar cholangiocarcinoma: Long-term resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the overall long-term survival was relatively low in our inhomogeneous cohort but favorable in patients without metastases. However, because of the increased perioperative mortality, EBDR is not recommended as a standard procedure for hilar cholangiocarcinoma instead of LT alone. To further improve the results, other approaches such as (neo)adjuvant therapy have to be increasingly investigated. Liver Transpl 15:1499-1507, 2009. © 2009 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - October 28, 2009 Category: Transplant Surgery Authors: Daniel Seehofer, Armin thelen, Ulf P. Neumann, Winfried Veltzke-Schlieker, Timm Denecke, Carsten Kamphues, Johann Pratschke, Sven Jonas, Peter Neuhaus Tags: Original Articles Source Type: journals

Liver tumor infiltrating lymphocytes: comparison of hepatocellular and cholangiolar carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Liver TIL consists of intratumoral CD8+ T cells and peritumoral CD4+ T cells independent of histogenetic origin. Different functions of lymphocytes in these regions seem possible. PMID: 19859998 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 28, 2009 Category: Gastroenterology Authors: Kasper HU, Drebber U, Stippel DL, Dienes HP, Gillessen A Tags: World J Gastroenterol Source Type: journals

Surgical treatment of hilar cholangiocarcinoma in a new era: comparison among leading Eastern and Western centers, LeedsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Radical surgery continues to offer the prospect of long-term survival for patients with HCCA. Earlier detection and referral to tertiary centers may allow more patients to have potentially curative surgical resections. Content Type Journal ArticleCategory TopicsDOI 10.1007/s00534-009-0203-6Authors Alastair L. Young, St James’s University Hospital HPB and Transplant Unit, Lincoln Wing Leeds LS9 7TF UKK. Rajendra Prasad, St James’s University Hospital HPB and Transplant Unit, Lincoln Wing Leeds LS9 7TF UKGiles J. Toogood, St James’s University Hospital HPB and Transplant Unit, Lincoln Wi...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 27, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Surgical treatment of hilar cholangiocarcinoma in the new era: the Asan experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Preoperative biliary decompression and portal vein embolization enabled us to reduce in-hospital deaths associated with extended hepatectomy for hilar cholangiocarcinoma. Major hemihepatectomy offers an increased survival because of the higher possibility of curative resection than bile duct resection alone and parenchyma-preserving hepatectomy, but it still carries a certain mortality. Less extensive procedures can be conducted safely and are beneficial for aged patients in poor condition with a less advanced tumor stage if tumor-free resectional margins are obtained. Content Type Journal ...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 22, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Characterization of CD133(+) parenchymal cells in the liver: Histology and culture.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study revealed that CD133 could be a biliary and progenitor cell marker in vivo. However, CD133 alone is not sufficient to detect tumor-initiating cells in cell lines. PMID: 19842219 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 20, 2009 Category: Gastroenterology Authors: Yoshikawa S, Zen Y, Fujii T, Sato Y, Ohta T, Aoyagi Y, Nakanuma Y Tags: World J Gastroenterol Source Type: journals

Cholangiocarcinoma may be familial and associated with malignant melanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a family with familial cancer of the gallbladder and melanoma. Further descriptions may lead to a better delineation of a hereditary component in adenocarcinoma of the gallbladder. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - October 16, 2009 Category: Cancer & Oncology Authors: Patrick Morrison, D. Donnelly Tags: Abstracts Source Type: journals

Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: a case–control study in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risk factors for cholangiocarcinoma are incompletely defined in China, especially for intrahepatic cholangiocarcinoma (ICC). We evaluated the risk factors for both ICC and extrahepatic cholangiocarcinoma (ECC). A case[ndash]control study in which cases were cholangiocarcinoma patients referred to Peking Union Medical College Hospital (PUMCH) between 1998 and 2008 and controls were healthy individuals. Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center of PUMCH. Data on liver disease, family history, diabetes, smoking and drinking were collected by a retrospec...
Source: Liver International - October 13, 2009 Category: Gastroenterology Authors: Lian-Yuan Tao, Xiao-Dong He, Qiang Qu, Lei Cai, Wei Liu, Li Zhou, Shang-Ming Zhang Source Type: journals

Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were ...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Yoichiro Yamamoto, Junichi Chikawa, Yoshinobu Uegaki, Nobuteru Usuda, Yoshikazu Kuwahara, Manabu Fukumoto Source Type: journals

Outcome of surgical treatment of hilar cholangiocarcinoma: a special reference to postoperative morbidity and mortalityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Aggressive resection for hilar cholangiocarcinoma, performed in accordance with strict management strategy, achieved acceptably low mortality. Prolonged operative time was a risk for morbidity following hepatobiliary resection. Content Type Journal ArticleCategory TopicsDOI 10.1007/s00534-009-0208-1Authors Satoshi Hirano, Hokkaido University Graduate School of Medicine Department of Surgical Oncology Kita-15, Nishi-7, Kita-Ku Sapporo 060-8638 JapanSatoshi Kondo, Hokkaido University Graduate School of Medicine Department of Surgical Oncology Kita-15, Nishi-7, Kita-Ku Sapporo 060-8638 JapanEi...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 10, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Photodynamic therapy is associated with an improvement in survival in patients with irresectable hilar cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This prospective clinical cohort study has demonstrated that radical surgery and palliative Photofrin-PDT are associated with an increased survival in patients with hilar cholangiocarcinoma. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 9, 2009 Category: Gastroenterology Authors: Aaron J. Quyn, Dorin Ziyaie, Francesco M. Polignano, Iain S. Tait Source Type: journals

Surgical treatment of hilar cholangiocarcinoma in the “new era”: the Nagoya University experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The surgical approach to hilar cholangiocarcinoma has become more challenging in the new era. Nevertheless, surgical outcomes have been improved, with decreased morbidity and mortality rates being observed. Long-term survival has also steadily improved. These findings indicate that biliary surgeons should use an aggressive surgical strategy to treat this intractable disease. Content Type Journal ArticleCategory TopicsDOI 10.1007/s00534-009-0209-0Authors Tsuyoshi Igami, Nagoya University Graduate School of Medicine Division of Surgical Oncology, Department of Surgery 65 Tsurumai-cho, Showa-...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 6, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Hilar cholangiocarcinoma: the Memorial Sloan-Kettering Cancer Center experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions R0 resection including hepatectomy with negative lymph nodes is feasible in the majority of patients with resectable HCCA. This strategy is associated with a prolonged disease-specific survival. Content Type Journal ArticleCategory TopicsDOI 10.1007/s00534-009-0205-4Authors Flavio G. Rocha, Memorial Sloan-Kettering Cancer Center Hepatopancreatobiliary Service, Department of Surgery 1275 York Avenue New York NY 10065 USAKenichi Matsuo, Memorial Sloan-Kettering Cancer Center Hepatopancreatobiliary Service, Department of Surgery 1275 York Avenue New York NY 10065 USALeslie H. Blumgart, Memoria...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - October 6, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study suggests a possible mechanism by which carcinoma cells but not normal cells are sensitive to SAHA and indicates the efficacy of this new anticancer agent in combination with EZH2 repression in gallbladder carcinoma. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - October 6, 2009 Category: Cancer & Oncology Authors: Junpei Yamaguchi, Motoko Sasaki, Yasunori Sato, Keita Itatsu, Kenichi Harada, Yoh Zen, Hiroko Ikeda, Yuji Nimura, Masato Nagino, Yasuni Nakanuma Source Type: journals

Drug-eluting bead therapy in primary and metastatic disease of the liverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Drug-eluting bead TACE is becoming more widely utilized in primary and liver-dominant metastatic disease of the liver. Outcomes of success must be expanded beyond response rates because these are not a reliable surrogate for progression-free survival or overall survival. Ongoing clinical trials will further clarify the optimal timing and strategy of this technology. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - October 4, 2009 Category: Gastroenterology Authors: Stewart Carter, Robert C. G. Martin II Source Type: journals

Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
EndoscopyDOI: 10.1055/s-0029-1215178 Localized-type bile duct carcinoma (LBDC) is often accompanied by extensive intraepithelial tumor spread (ITS) of 2 cm or more, which makes radical resection more difficult. This retrospective case review compares the diagnostic accuracy of endoscopic retrograde cholangiography (ERC) and peroral cholangioscopy (POCS) to detect ITS beyond the visible LBDC.[...]© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents | Abstract | Full text (Source: Endoscopy)
Source: Endoscopy - October 3, 2009 Category: Gastroenterology Tags: Original article Source Type: journals

Expression of thioredoxin during progression of hamster and human cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thioredoxin (Trx) is a multifunctional redox protein that has growth-promoting and anti-apoptotic effects on cells and protects cells from endogenous and exogenous free radicals. Recently, altered expression of Trx has been reported in various cancers. In the present study, we investigated altered expression of Trx at the precancerous and carcinogenic phases during cholangiocarcinogenesis in a hamster cholangiocarcinoma (ChC) model, using semiquantitative immunohistochemical and Western blot analyses. Moreover, to determine if the results correlated well with those in human ChCs, we carried out a comparative immunohistoche...
Source: Cancer Science - October 1, 2009 Category: Cancer & Oncology Authors: Byung-Il Yoon, Yeong-Hun Kim, Jung-Yeon Yi, Min-Soo Kang, Ja-June Jang, Kyoung-Hwan Joo, Yongbaek Kim, J. McHugh Law, Dae-Yong Kim Source Type: journals

Cholangioscopy for Special Applications: Primary Sclerosing Cholangitis, Liver Transplant, and Selective Duct AccessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cholangioscopy is gaining renewed interest and gradually expanded use as a result of recent technical improvements in endoscopes and accessories, coupled with shortcomings in the accuracy of currently available techniques for biliary sampling and diagnosis. Challenging clinical dilemmas that may benefit from its application include early diagnosis of cholangiocarcinoma in the setting of primary sclerosing cholangitis, early identification of biliary infection or ischemia following orthotopic liver transplantation, and selective duct access with wires and other devices during therapeutic endoscopic retrograde cholangiopancr...
Source: Gastrointestinal Endoscopy Clinics of North America - October 1, 2009 Category: Gastroenterology Authors: Bret T. Petersen Source Type: journals

Proteomic analysis of differentially expressed proteins in human cholangiocarcinoma cells treated with Clonorchis sinensis excretory-secretory productsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Severe Clonorchis sinensis infection is a significant risk factor for malignant changes in bile ducts and surrounding liver tissues occurring as a result of direct contact with C. sinensis worms and their excretory-secretory products (ESP). However, the intrinsic molecular mechanisms involved in these processes remain obscure. To determine the effects of C. sinensis infection on protein expression in host bile duct epithelium, we examined proteomic profile changes in the human cholangiocarcinoma cell line (HuCCT1) treated with ESP at 24 h. Using a combination of 2-DE, quantitative image and MALDI-TOF MS analysis, we identi...
Source: Journal of Cellular Biochemistry - September 30, 2009 Category: Biochemistry Authors: Jhang Ho Pak, Ju Hyun Moon, Seung-Jun Hwang, Shin-Hyeong Cho, Sang-Beom Seo, Tong-Soo Kim Source Type: journals

Primary biliary lymphoma mimicking cholangiocarcinoma: a characteristic feature of discrepant CT and direct cholangiography findings.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of a patient with extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), who presented with obstructive jaundice and describe the distinctive radiologic features that may suggest the correct preoperative diagnosis of primary lymphoma of the bile duct. Primary MALT lymphoma of the extrahepatic bile duct should be considered in the differential diagnosis when there is a mismatch in imaging findings on computed tomography or magnetic resonance imaging and cholangiography. PMID: 19794999 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - September 30, 2009 Category: Journals (General) Authors: Yoon MA, Lee JM, Kim SH, Lee JY, Han JK, Choi BI, Kim SW, Jang JJ Tags: J Korean Med Sci Source Type: journals

Primary actinomycosis of the liver mimicking malignancy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 71-year old women presented with fever, a significant loss of body weight and abdominal pain in the upper right quadrant since approximately six months. Abdominal ultrasonography and magnetic resonance imaging (MRI) showed an irregularly shaped, inhomogeneous and hypointense lesion of the right liver lobe (6 x 8 cm in segment 7 and 8) with multiple satellite lesions. Irregular shape, hypovascular presentation during gadolinium enhancement, hypointensity in T 1-weighted images and dilation of peripheral bile ducts were suggestive for cholangiocarcinoma or metastasis. However, histological investigations revealed a rar...
Source: Zeitschrift fur Gastroenterologie - September 30, 2009 Category: Gastroenterology Authors: Lange CM, Hofmann WP, Kriener S, Jacobi V, Welsch C, Just-Nuebling G, Zeuzem S Tags: Z Gastroenterol Source Type: journals

[Clinical Characteristics of Intrahepatic Cholangiocarcinoma and Prognostic Factors in Patients Who Received Non-surgical Treatment.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prognostic factors of ICC in patients who did not receive surgery were ALP and bilirubin levels, but not lymph node metastasis. PMID: 19844142 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - September 30, 2009 Category: Gastroenterology Authors: Eun JR, Jang BI, Lee JY, Kim KO, Lee SH, Kim TN, Lee HJ Tags: Korean J Gastroenterol Source Type: journals

CholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a rare, primary cancer of the biliary tree that can be difficult to diagnose with all imaging modalities. The presenting clinical symptoms of nausea, vomiting, and jaundice can be consistent with classic cholecystitis symptoms, increasing the risk of a missed diagnosis. The most often seen risk factor for cholangiocarcinoma is primary sclerosing cholangitis (PSC). In most cases, the initial diagnostic finding is intrahepatic ductal dilatation. Once an actual mass is seen, liver transplantation is the necessary treatment plan because of likely hepatic metastasis. There is a slight recurrence rate of cholangiocarcinoma e...
Source: Journal of Diagnostic Medical Sonography - September 29, 2009 Category: Radiology Authors: Whitlock, P. J. Tags: Articles Source Type: journals

Mesh-metal stents for hilar cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest the article by Paik et al addressing the optimal route of self-expanding metal stent (SEMS) insertion in patients with unresectable hilar cholangiocarcinoma and concluding that a percutaneous approach is significantly more likely to lead to successful drainage than an endoscopic approach. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - September 29, 2009 Category: Gastroenterology Authors: George Webster, Stephen Pereira Tags: Letters to the Editor Source Type: journals

Significance of mucin expression in pancreatobiliary neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Mucins are high molecular weight glycoproteins that play important roles in carcinogenesis and tumor invasion. We have described, for the first time, that pancreatic ductal adenocarcinomas (PDACs) with an aggressive behavior and a poor outcome expressed MUC1 (pan-epithelial membrane-associated mucin) but did not express MUC2 (intestinal-type secreted mucin), whereas intraductal papillary mucinous neoplasms (IPMNs) with indolent behavior and a favorable outcome did not express MUC1 but did express MUC2. These expression profiles of MUC1 and MUC2 related to the prognoses of the patients were also obse...
Source: Journal of Hepato-Biliary-Pancreatic Surgery - September 29, 2009 Category: Surgery Tags: Journal of Hepato-Biliary-Pancreatic Surgery Source Type: journals

Diagnostic role of serum glypican-3 in differentiating hepatocellular carcinoma from non-malignant chronic liver disease and other liver cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Serum GPC3 is highly specific for detecting HCC. The combined use of serum GPC3 and AFP provides a potentially promising tool to better differentiate HCC from benign liver disorders, as well as from other liver cancers. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - September 26, 2009 Category: Gastroenterology Authors: Pisit Tangkijvanich, theerawut Chanmee, Sanpoj Komtong, Varocha Mahachai, Naruemon Wisedopas, Peraphan Pothacharoen, Prachya Kongtawelert Source Type: journals

Repetitive response to gemcitabine that led to curative resection in cholangiocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study reports a case of unresectable intrahepatic mass-forming cholangiocarcinoma which showed a dramatic response to gemcitabine that led to curative resection and a long-term survival of more than five years. Six and five cycles of gemcitabine monotherapy were administered separately over a three-year period and a radical excision was performed at 4.5 years after diagnosis. This case indicates the role of gemcitabine as a neoadjuvant chemotherapeutic agent for cholangiocarcinoma and guarantees a randomized controlled prospective study. PMID: 19777621 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - September 26, 2009 Category: Gastroenterology Authors: Kim SH, Kim IH, Kim SW, Lee SO Tags: World J Gastroenterol Source Type: journals

Biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma with jaundiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results confirm the beneficial effect of biliary drainage, photodynamic therapy and chemotherapy for unresectable cholangiocarcinoma in selected patients with jaundice. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - September 24, 2009 Category: Gastroenterology Authors: David Fuks, Eric Bartoli, Richard Delcenserie, Thierry Yzet, Pierre Celice, Charles Sabbagh, Denis Chatelain, Jean-Paul Joly, Nathalie Cheron, Jean-Louis Dupas, Jean-Marc Regimbeau Source Type: journals

Intraductal ultrasonography combined with percutaneous transhepatic cholangioscopy for the preoperative evaluation of longitudinal tumor extent in hilar cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The combination of IDUS and PTCS with biopsy was highly accurate for assessing Bismuth type and may help in the identification of an optimal surgical plan for the treatment of hilar cholangiocarcinoma, especially in Bismuth type IIIa, IIIb, or IV. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - September 24, 2009 Category: Gastroenterology Authors: Hee Man Kim, Jeong Youp Park, Kyung Sik Kim, Mi-Suk Park, Myeong-Jin Kim, Young Nyun Park, Seungmin Bang, Si Young Song, Jae Bock Chung, Seung Woo Park Source Type: journals

Hematoporphyrin derivative-mediated photodynamic therapy inhibits tumor growth in human cholangiocarcinoma in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HPD-PDT inhibits tumor growth of human cholangiocarcinoma, suggesting that HPD-PDT is useful in cholangiocarcinoma therapy. (Source: Hepatology Research)
Source: Hepatology Research - September 24, 2009 Category: Internal Medicine Authors: Liang-qi Cao, Ping Xue, Hai-wu Lu, Qiang Zheng, Zi-long Wen, Zhi-jian Shao Source Type: journals

Initial Presentation and Management of Hilar and Peripheral Cholangiocarcinoma: Is a Node-Positive Status or Potential Margin-Positive Result a Contraindication to Resection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Survival benefits can be achieved with resection for cholangiocarcinoma. Given the lack of effective alternative therapy, when confronted with the potential risk of positive margins or isolated nodal disease, we continue to advocate aggressive surgical resection for both hilar and peripheral CC with the ultimate goal of negative margin resection. Content Type Journal ArticleCategory Hepatobiliary and Pancreatic TumorsDOI 10.1245/s10434-009-0701-4Authors Kevin Tri Nguyen, UPMC Liver Cancer Center, University of Pittsburgh Department of Surgery Pittsburgh Pennsylvania USAJennifer Steel, UPMC...
Source: Annals of Surgical Oncology - September 24, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Hypervascular Liver LesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hypervascular hepatocellular lesions include both benign and malignant etiologies. In the benign category, focal nodular hyperplasia and adenoma are typically hypervascular. In addition, some regenerative nodules in cirrhosis may be hypervascular. Malignant hypervascular primary hepatocellular lesions include hepatocellular carcinoma, fibrolamellar carcinoma, and peripheral cholangiocarcinoma. Vascular liver lesions often appear hypervascular because they tend to follow the enhancement of the blood pool; these include hemangiomas, arteriovenous malformations, angiosarcomas, and peliosis. While most gastrointestinal maligna...
Source: Seminars in Ultrasound CT and MRI - September 23, 2009 Category: Radiology Authors: Aya Kamaya, Katherine E. Maturen, Grace A. Tye, Yueyi I. Liu, Naveen N. Parti, Terry S. Desser Source Type: journals