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This page shows you the latest news and research items in this category.

Cholangiocarcinoma: The Next Asbestos-Related Disease?
Researchers from the University of Bologna noted that many of their cholangiocarcinoma patients had a history of asbestos exposure. In a recent study to further investigate the correlation, they found that asbestos exposure may be an occupational risk factor for cholangiocarcinoma. (Source: Asbestos and Mesothelioma News)
Source: Asbestos and Mesothelioma News - February 28, 2013 Category: Environmental Health Authors: faith Tags: Asbestos Exposure Asbestos Cancer Research Source Type: news

Excellent quality of life after liver transplantation in patients with perihilar cholangiocarcinoma who have undergone neoadjuvant chemoradiation
In conclusion, patients who underwent neoadjuvant chemoradiation followed by LTx for perihilar CCA report excellent quality of life, which is equal to or better than recipients with other liver diseases. These results are important in light of the continued debate about the feasibility of this aggressive treatment in patients with perihilar CCA. © 2013 American Association for the Study of Liver Diseases (Source: Liver Transplantation)
Source: Liver Transplantation - February 27, 2013 Category: Transplant Surgery Authors: Sarwa Darwish Murad, Julie K. Heimbach, Gregory J. Gores, Charles B. Rosen, Joanne T. Benson, W. Ray Kim Tags: Original Article Source Type: research

Double primary hepatic cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) in a single patient: a clinicopathologic study of 35 resected cases
ConclusionDouble hepatic cancer of HCC and ICC is very rare with distinctive clinicopathologic features. The prognosis of double hepatic cancer was as poor as pure ICC. The ICC component played a more important role than the HCC component in influencing the prognosis of double hepatic cancer. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Jie Cao, Liang Huang, Caifeng Liu, Jing Li, Xianghua Zhang, Jun Shen, Jun Li, Lun Lu, Feng Xu, Jianjun Yan, Mengchao Wu, Wan Yee Lau, Yiqun Yan Tags: Clinical Hepatology Source Type: research

Adenocarcinoma of gallbladder: an immunohistochemical profile and comparison with cholangiocarcinoma
Conclusions Adenocarcinomas of gallbladder generally arise from a foregut cell lineage via a metaplasia-dysplasia-carcinoma sequence. A background of chronic inflammation increases the frequency of expression of an intestinal goblet-cell phenotype and p53 in the cancers. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - February 21, 2013 Category: Pathology Authors: Hughes, N. R., Bhathal, P. S. Tags: Pancreas and biliary tract, Immunology (including allergy), Breast cancer, Hepatic cancer, Inflammation Original article Source Type: research

Aminolevulinic acid derivatives-based photodynamic therapy in human intra- and extrahepatic cholangiocarcinoma cells.
Abstract Hexyl-aminolevulinic acid (HALA) was compared with aminolevulinic acid (ALA) in terms of improving ALA-based photodynamic therapy (PDT) for human intra- and extrahepatic cholangiocarcinoma (CCA) HuCC-T1 and SNU1196 cells. Because of the different uptake mechanisms of HALA, a relatively higher amount of protoporphyrin IX (PpIX) was induced in the both CCA cell types at low concentrations of HALA. Furthermore, higher expression of porphobilinogen deaminase, coproporphyrinogen III oxidase, and protoporphyrinogen oxidase, the key enzymes for synthesizing PpIX in the heme biosynthetic pathway, facilitated the e...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 18, 2013 Category: Drugs & Pharmacology Authors: Chung CW, Kim CH, Lee HM, Kim DH, Kwak TW, Chung KD, Jeong YI, Kang DH Tags: Eur J Pharm Biopharm Source Type: research

Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy
Conclusion We found EGFR aberrations in 1.6% of a large group of patients with diverse tumors other than NSCLC, and treatment with an EGFR inhibitor could be associated with prolonged SD. (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Wheler, J. J., Falchook, G. S., Tsimberidou, A. M., Hong, D. S., Naing, A., Piha-Paul, S. A., Chen, S. S., Fu, S., Stephen, B., Fok, J. Y., Janku, F., Kurzrock, R. Tags: clinical trials Source Type: research

Treatment of recurrent intrahepatic cholangiocarcinoma (Br J Surg2012; 99: 1711-1717).
PMID: 23378206 [PubMed - in process] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - February 13, 2013 Category: Surgery Authors: Fujita T Tags: Br J Surg Source Type: research

Author's reply: Treatment of recurrent intrahepatic cholangiocarcinoma (Br J Surg 2012; 99: 1711-1717).
PMID: 23378208 [PubMed - in process] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - February 13, 2013 Category: Surgery Authors: Boudjema K Tags: Br J Surg Source Type: research

The mTOR pathway in hepatic malignancies
Abstract The mechanistic/mammalian target of rapamycin (mTOR) pathway plays a critical role in cellular metabolism, growth and proliferation, and has been evaluated as a target for therapy in various malignancies. The mTOR pathway is a major tumor‐initiating pathway in hepatocellular carcinoma, with upregulation seen in up to 50% of (HCC) tumors. Metformin, which represses mTOR signaling by activating AMPK, has been shown to decrease liver carcinogenesis in population studies. mTOR inhibitors such as everolimus have been evaluated as adjunctive chemotherapy with some success, although efficacy has been limited by the lac...
Source: Hepatology - February 13, 2013 Category: Internal Medicine Authors: Mamatha Bhat, Nahum Sonenberg, Gregory Gores Tags: Hepatobiliary Malignancies Source Type: research

Notching up on the cellular origins of intrahepatic cholangiocarcinoma
(Source: Hepatology)
Source: Hepatology - February 6, 2013 Category: Internal Medicine Authors: Alphonse E. Sirica Tags: Hepatobiliary Malignancies Source Type: research

Transplantation versus resection for patients with combined hepatocellular carcinoma–cholangiocarcinoma
ConclusionsTransplantation for localized cHCC–CC confers a survival benefit similar to liver resection for cHCC–CC, but inferior to transplantation for HCC. With survival data that mimics historic reports of transplant for intrahepatic cholangiocarcinoma, this study questions the benefit of transplantation for patients with cHCC–CC. J. Surg. Oncol © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - February 5, 2013 Category: Cancer & Oncology Authors: Ryan T. Groeschl, Kiran K. Turaga, T. Clark Gamblin Tags: Research Article Source Type: research

Treatment of recurrent intrahepatic cholangiocarcinoma (Br J Surg2012; 99: 1711–1717)
(Source: British Journal of Surgery)
Source: British Journal of Surgery - February 4, 2013 Category: Surgery Authors: T. Fujita Tags: Your Views Source Type: research

Author's reply: Treatment of recurrent intrahepatic cholangiocarcinoma (Br J Surg 2012; 99: 1711–1717)
(Source: British Journal of Surgery)
Source: British Journal of Surgery - February 4, 2013 Category: Surgery Authors: K. Boudjema Tags: Your Views Source Type: research

Spread of hilar cholangiocarcinomas via peribiliary gland network: a hither-to-unrecognized route of periductal infiltration.
In conclusion, the present study showed a unique form of periductal spread of CCs with preferential and extensive involvement of the peribiliary gland networks. PMID: 23330019 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 2, 2013 Category: Pathology Authors: Sato H, Nakanuma Y, Kozaka K, Sato Y, Ikeda H Tags: Int J Clin Exp Pathol Source Type: research

Preoperative Hepatobiliary Imaging: What Does the Radiologist Need to Know?
Accurate preoperative reporting is essential in guiding the surgeon in deciding when and how to operate safely and effectively. Critically, this relies on an understanding of the operative issues faced by the surgeon, which is not always appreciated by the radiologist. This paper therefore aims to address this, first focusing on relevant anatomical variants, and then issues specific to laparoscopic cholecystectomy, hepatic transplantation, and finally hepatic resection (including cholangiocarcinoma resection). Throughout the paper, there is an emphasis on associated surgical techniques to add context to the discussion. (So...
Source: Seminars in Ultrasound CT and MRI - February 1, 2013 Category: Radiology Authors: Andrew Wigham, Lee Alexander Grant Source Type: research

Positron Emission Tomography-Computed Tomography in Liver Imaging
The relatively new technique of positron emission tomography (PET) that incorporates both anatomy and function is increasingly being utilized in oncological imaging. This review assesses the use of PET of the liver for optimal and appropriate patient clinical management. The role of PET in both liver-lesion detection and characterization is discussed (including the context of primary liver malignancy, hepatocellular carcinoma, cholangiocarcinoma, metastatic disease from colorectal cancer and other tumor types). The use of functional PET imaging for prognostication, efficacy pre–liver transplantation, response assessment ...
Source: Seminars in Ultrasound CT and MRI - February 1, 2013 Category: Radiology Authors: Bhuey Sharma, Axel Martin, Imene Zerizer Source Type: research

Mucins 1-shRNA inhibit the proliferation and HIF-1alpha protein expression on human cholangiocarcinoma cells.
Abstract To explore the effects of Mucins (MUC)1-shRNA on the proliferation and hypoxia inducible factor (HIF)-1alpha expression of human cholangiocarcinoma (CCA) QBC939 cells in vitro. MUC1-shRNA was constructed and transfected with Lipofectamine™ 2000 into cultured CCA cells. MUC1 mRNA and protein expression levels were determined by RT-PCR and Western blot, respectively. The cellular proliferation and HIF-1alpha expression of QBC939 cells were evaluated by the MTT assay and Western blot, respectively. After transfection, the expression levels of MUC1 mRNA and protein in the experimental group decreased signifi...
Source: Cell Biology International - January 30, 2013 Category: Cytology Authors: Li ZR, Wei JL, Li ZZ, Li SF Tags: Cell Biol Int Source Type: research

67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis
The 67-kDa laminin receptor (67LR) is a laminin-binding protein overexpressed in various types of cancer, including bile duct carcinoma, colorectal carcinoma, cervical cancer, and breast carcinoma. 67LR plays a vital role in growth and metastasis of tumor cells and resistance to chemotherapy. Here, we show that 67LR functions as a cancer-specific death receptor. In this cell death receptor pathway, cGMP initiated cancer-specific cell death by activating the PKCδ/acid sphingomyelinase (PKCδ/ASM) pathway. Furthermore, upregulation of cGMP was a rate-determining process of 67LR-dependent cell death induced by the ...
Source: Journal of Clinical Investigation - January 26, 2013 Category: Biomedical Science Authors: Motofumi Kumazoe, Kaori Sugihara, Shuntaro Tsukamoto, Yuhui Huang, Yukari Tsurudome, Takashi Suzuki, Yumi Suemasu, Naoki Ueda, Shuya Yamashita, Yoonhee Kim, Koji Yamada, Hirofumi Tachibana Source Type: research

Asia‐Pacific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma
Abstract Hilar cholangiocarcinoma (HCCA) is one of the most common types of hepatobiliary cancers reported in the world including Asia Pacific region. Early HCCA may be completely asymptomatic. When significant hilar obstruction develops, the patient presents with jaundice, pale stools, dark urine, pruritus, abdominal pain, and sometimes fever. Since no single test can establish the definite diagnosis then a combination of many investigations such as tumour markers, tissue acquisition, CT scan, MRI/MRCP, EUS/IDUS, and advanced cholangioscopy is required. Surgery is the only curative treatment. Unfortunately, the majority o...
Source: Journal of Gastroenterology and Hepatology - January 25, 2013 Category: Gastroenterology Authors: Rungsun Rerknimitr, Phonthep Angsuwatcharakon, Thawee Ratanachu‐ek, Christopher J. L. Khor, Ryan Ponnudurai, Jong H Moon, Dong Wan Seo, Linda Pantongrag‐Brown, Apichat Sangchan, Pises Pisespongsa, Thawatchai Akaraviputh, Duvvuru Nageshwar Reddy, Amit Tags: Review Article Source Type: research

Patterns Of Appearance And Risk Of Misdiagnosis Of Intrahepatic Cholangiocarcinoma In Cirrhosis At Contrast Enhanced Ultrasound
ConclusionsCEUS misdiagnosed as HCC a significantly higher number of ICC lesions in cirrhotic patients than CT and MRI. However, some CEUS contrast features can help to suspect ICC, expecially in some cases with inconclusive CT or MRI.© 2013 John Wiley & Sons A/S (Source: Liver International)
Source: Liver International - January 25, 2013 Category: Gastroenterology Authors: Marzia Galassi, Massimo Iavarone, Sandro Rossi, Simona Bota, Sara Vavassori, Laura Rosa, Simona Leoni, Laura Venerandi, Sara Marinelli, Angelo Sangiovanni, Letizia Veronese, Mirella Fraquelli, Alessandro Granito, Rita Golfieri, Massimo Colombo, Luigi Bolo Tags: Original Article Source Type: research

Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
& Sanjay Kakar (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - January 25, 2013 Category: Pathology Authors: Gregor KringsRageshree RamachandranDhanpat JainTsung-Teh WuMatthew M YehMichael TorbensonSanjay Kakar Tags: arginase cholangiocarcinoma glypican 3 scirrhous hepatocellular carcinoma Source Type: research

Inhibition of hedgehog signaling attenuates carcinogenesis in vitro and increases necrosis of cholangiocellular carcinoma
Conclusion: This study supports the presence of autocrine Hedgehog signaling in human CCC, where CCC cells produce and respond to Shh ligand. Blocking the Hedgehog pathway inhibited EMT and decreased the viability of CCC cells. In addition, cyclopamine and 5E1 inhibited the growth of CCC xenograft tumors. (HEPATOLOGY 2013) (Source: Hepatology)
Source: Hepatology - January 25, 2013 Category: Internal Medicine Authors: Mona El Khatib, Anna Kalnytska, Vindhya Palagani, Uta Kossatz, Michael P. Manns, Nisar P. Malek, Ludwig Wilkens, Ruben R. Plentz Tags: Hepatobiliary Malignancies Source Type: research

Metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice.
We report an extremely rare case of metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. The patient was a 76-year-old male, who presented with generalized weakness and right upper quadrant pain. Plain chest X-ray noted multiple small nodules in both lung fields. Abdominal computed tomography scan showed a stricture of the mid common bile duct along with ductal wall enhancement. Endoscopic retrograde cholangiography revealed a concentric, abrupt narrowing of the mid-common bile duct suggestive of primary bile duct cancer. However, pathology comfirmed metastatic common bile du...
Source: Korean J Gastroenter... - January 25, 2013 Category: Gastroenterology Authors: Cha IH, Kim JN, Kim YS, Ryu SH, Moon JS, Lee HK Tags: Korean J Gastroenterol Source Type: research

[Massive bleeding hemobilia occurred in patient with hepatocellular carcinoma].
We report an extremely rare case of metastatic common bile duct cancer from pulmonary adenocarcinoma presenting as obstructive jaundice. The patient was a 76-year-old male, who presented with generalized weakness and right upper quadrant pain. Plain chest X-ray noted multiple small nodules in both lung fields. Abdominal computed tomography scan showed a stricture of the mid common bile duct along with ductal wall enhancement. Endoscopic retrograde cholangiography revealed a concentric, abrupt narrowing of the mid-common bile duct suggestive of primary bile duct cancer. However, pathology comfirmed metastatic common bi...
Source: Korean J Gastroenter... - January 25, 2013 Category: Gastroenterology Authors: Lee KE, Kim CW, Kim MJ, Park J, Cho GM, Jang JW, Lee YS, Lee CD Tags: Korean J Gastroenterol Source Type: research

Utility of immunocytochemistry in diagnosing leptomeningeal metastases from an intrahepatic cholangiocarcinoma
We report a case of intrahepatic cholangiocarcinoma with spinal LMM confirmed using cytokeratin7 and pancytokeratin (AE1/AE3) immunocytochemical studies on paucicellular cerebrospinal fluid cytospin preparation. Given the paucicellularity of the smears and difficult morphologic categorization, immunocytochemistry is vital for confirmatory diagnosis and can help reduce false negative results. To the best of our knowledgethis is the first case report of cytologically confirmed LMM from an intrahepatic cholangiocarcinoma while the patient was undergoing treatment. © 2013 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - January 22, 2013 Category: Pathology Authors: Shweta Chaudhary, Melissa Klein, Bhoomi Mehrotra, Nora J. Morgenstern Tags: Brief Report Source Type: research

Comparison of laparoscopic and open intraoperative ultrasonography for staging liver tumours
Conclusion:Laparoscopic IOUS is a reliable tool for staging liver tumours with a performance similar to that of open IOUS in detecting new nodules. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 21, 2013 Category: Surgery Authors: L. Viganò, A. Ferrero, M. Amisano, N. Russolillo, L. Capussotti Tags: Original Article Source Type: research

KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas
CONCLUSIONS:KRAS mutations, which were present in approximately 33% of BilIN lesions, occurred as an early molecular event during the progression of BilIN to ICC, whereas p53 overexpression was identified as a late molecular event. Furthermore, the current results indicted that BilIN also may arise from LBD and PBG lesions in patients who have hepatolithiasis with KRAS mutations. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - January 18, 2013 Category: Cancer & Oncology Authors: Maylee Hsu, Motoko Sasaki, Saya Igarashi, Yasunori Sato, Yasuni Nakanuma Tags: Original Article Source Type: research

Jaundice and life‐threatening hemobilia: An uncommon presentation of adult choledochal cysts
Adult choledochal or biliary cysts, thought to arise due to abnormalities in the pancreatico‐biliary junction, are not uncommon, particularly in Asia.1 Clinical presentation of choledochal cysts vary from being asymptomatic to jaundice development, an abdominal mass or even cholangitis and pancreatitis.2 It is also associated with an increased risk of malignancies where cases of cholangiocarcinoma have been reported.3 Choledochal cyst presenting with gastrointestinal (GI) bleeding due to hemobilia together with jaundice is a rare presentation. Establishing a diagnosis can be difficult and the clinical outcome can be deva...
Source: Chinese Journal of Digestive Diseases - January 16, 2013 Category: Gastroenterology Authors: Peng Soon Koh, Boon Koon Yoong, Anushya Vijayananthan, Ouzreiah Nawawi, Sanjiv Mahadeva Tags: Case Report Source Type: research

Therapeutic Deletion of CAFs in Cholangiocarcinoma
Cancer-associated fibroblasts (CAF) are abundant in the stroma of desmoplastic cancers where they promote tumor progression. CAFs are “activated” and as such may be uniquely susceptible to apoptosis. Using cholangiocarcinoma as a desmoplastic tumor model, we investigated the sensitivity of liver CAFs to the cytotoxic drug navitoclax, a BH3 mimetic. Navitoclax induced apoptosis in CAF and in myofibroblastic human hepatic stellate cells but lacked similar effects in quiescent fibroblasts or cholangiocarcinoma cells. Unlike cholangiocarcinoma cells, neither CAF nor quiescent fibroblasts expressed Mcl-1, a known resistance...
Source: Cancer Research - January 16, 2013 Category: Cancer & Oncology Authors: Mertens, J. C., Fingas, C. D., Christensen, J. D., Smoot, R. L., Bronk, S. F., Werneburg, N. W., Gustafson, M. P., Dietz, A. B., Roberts, L. R., Sirica, A. E., Gores, G. J. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Human liver carboxylesterase 1 outperforms alpha‐fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients
Abstract Although alpha‐fetoprotein is currently the major serologic biomarker for hepatocellular carcinoma (HCC), it cannot efficiently distinguish this cancer from other forms of liver disease in early diagnosis due to its low sensitivity. The aim of this study is to compare human carboxylesterase 1 (hCE1) biomarker sensitivity and specificity versus alpha‐fetoprotein (AFP). Antibody‐based assays for hCE1 and AFP were used to test both biomarkers with respect to diagnostic efficiency, Youden's index, and the area under the curve (AUC) through receiver operating characteristic (ROC) analysis in plasma from 208 patie...
Source: International Journal of Cancer - January 15, 2013 Category: Cancer & Oncology Authors: Keun Na, Seul‐Ki Jeong, Min‐Jung Lee, Sang Yun Cho, Sun A. Kim, Min‐Ji Lee, Si Young Song, Hoguen Kim, Kyung Sik Kim, Hyun Woong Lee, Young‐Ki Paik Tags: Early Detection and Diagnosis Source Type: research

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies
& J M Llovet (Source: Oncogene)
Source: Oncogene - January 14, 2013 Category: Cancer & Oncology Authors: D SiaV TovarA MoeiniJ M Llovet Tags: cholangiocarcinoma molecular pathogenesis targeted therapies Source Type: research

Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine‐induced hepatocellular carcinoma in mice
Abstract HNF4α, the master regulator of hepatocyte differentiation, has been recently shown to inhibit hepatocyte proliferation via unknown mechanisms. We investigated the mechanisms of HNF4α‐induced inhibition of hepatocyte proliferation using a novel TAM‐inducible, hepatocyte specific HNF4α knockdown mouse model. Hepatocyte specific deletion of HNF4αin adult mice resulted in increased hepatocyte proliferation with a significant increase in liver to body weight ratio. We determined global gene expression changes usingIlluminaHiSeq‐based RNA sequencing, which revealed that, a significant number of up‐regulated ...
Source: Hepatology - January 12, 2013 Category: Internal Medicine Authors: Chad Walesky, Genea Edwards, Prachi Borude, Sumedha Gunewardena, Maura O'Neil, Byunggil Yoo, Udayan Apte Tags: Liver Biology and Pathobiology Source Type: research

Activation of mTORC1 and Raf/Pyk2 by growth factor‐mediated EphA2 Is required for cholangiocarcinoma growth and metastasis
We examined the biological role of EphA2 in tumor growth and metastasis in CC tissues and cells according to the degree of differentiation and we explored the downstream signaling pathways of EphA2. Growth factor‐mediated EphA2 over‐expression itself leads to the activation of the mTORC1 and ERK pathways through ligand−independent activation of EphA2 (phosphorylation of S897). An in vitro soft agar assay and in vivo orthotopic or subcutaneous tumor model showed that EphA2 enhanced colony formation and accelerated tumor growth and, which seemed to be mainly associated with Akt (T308)/mTORC1 activation. Aberrant expres...
Source: Hepatology - January 11, 2013 Category: Internal Medicine Authors: Xiang‐Dan Cui, Mi‐Jin Lee, Jong‐Hyun Kim, Pei‐Pei Hao, Lan Liu, Goung‐Ran Yu, Dae‐Ghon Kim Tags: Hepatobiliary Malignancies Source Type: research

Feasibility of the Glissonian approach during right hepatectomy
ConclusionsThe right Glissonian approach was effective in 75% of patients. Failure of the procedure (including the extension of clamping to the left pedicle) mostly occurred in patients with portal vein variations, which can be accurately assessed using a combination of preoperative imaging and intraoperative Doppler ultrasound. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: Charlotte Mouly, David Fuks, François Browet, François Mauvais, Arnaud Potier, Thierry Yzet, Qassemyar Quentin, Jean‐Marc Regimbeau Tags: Original Article Source Type: research

Enhanced expression of farnesoid X receptor in human hepatocellular carcinoma
ConclusionContrary to previous reports, preserved or enhanced expression levels of nuclear FXR were detected in HCC, indicating that FXR may play significant roles in the biological behavior of HCC. (Source: Hepatology Research)
Source: Hepatology Research - January 10, 2013 Category: Internal Medicine Authors: Arisa Kumagai, Junichi Fukushima, Hajime Takikawa, Toshio Fukuda, Toshio Fukusato Tags: Original Article Source Type: research

Nonalcoholic Fatty Liver Disease Contributes to Hepatocellular Carcinoma in Non‐cirrhotic Liver: A Clinical and Pathological Study
Abstract Hepatocellular carcinoma (HCC) is a major complication of cirrhosis and has been increasing in incidence in recent years. Fatty liver disease is an increasingly common cause of chronic liver disease, and there have been several case reports of HCC in patients with non‐cirrhotic fatty liver disease. However, there is limited data from systematic studies with histological confirmation of the presence of both the HCC and the non‐cirrhotic fatty liver disease. We studied the occurrence of fatty liver disease and the associated demographic, clinical and pathological characteristics of a large cohort of patients wit...
Source: Journal of Gastroenterology and Hepatology - January 9, 2013 Category: Gastroenterology Authors: Jacob Alexander, Michael Torbenson, Tsung‐Teh Wu, Matthew M. Yeh Tags: Clinical Hepatology Source Type: research

Opisthorchis viverrini: implications of the systematics of first intermediate hosts, Bithynia snail species in Thailand and Lao PDR.
Abstract Bithynia snails are important hosts of the human liver fluke, Opisthorchis viverrini. Allozyme markers were used to examine genetic variation and the systematics of Bithynia snails from different geographical localities in Thailand and Lao PDR. Our results show that B. siamensis goniomphalos contains two major evolutionary clades with at least 9 morphologically similar but genetically distinct "cryptic" species (taxa). Clade A consists of snails from the Chi and the Mun River wetlands, Thailand and clade B consists of snails from the Nam Ngum River wetland, Lao PDR, as well as snails from some localities i...
Source: Infection, Genetics and Evolution - January 7, 2013 Category: Genetics & Stem Cells Authors: Kiatsopit N, Sithithaworn P, Saijuntha W, Petney TN, Andrews RH Tags: Infect Genet Evol Source Type: research

Pitfalls in the diagnosis of hepatic epithelioid hemangioendothelioma by FNA and needle core biopsy
This report describes a 64‐year‐old woman whom on computerized tomography was found to have multiple peripherally calcified hypodense lesions throughout the liver and an ipsilateral adrenal mass. Fine needle aspiration and needle cores biopsies of the largest liver lesion showed epithelioid cells and spindle cells in fibrous stroma. The epithelioid cells had round or oval, hyperchromatic nuclei with smooth nuclear contours, delicate cytoplasm and indistinct cytoplasmic borders. Rare cells had intracellular vascular lumen containing fragmented or intact red blood cells. The cells were individually dispersed or arranged ...
Source: Diagnostic Cytopathology - January 3, 2013 Category: Pathology Authors: Matthew Jurczyk, Bing Zhu, William Laskin, Xiaoqi Lin Tags: Brief Report Source Type: research

Expression of insulin-like growth factor II mRNA-binding protein 3 predicts early recurrence and poor prognosis in intrahepatic cholangiocarcinoma
Conclusions: IMP3 expression can serve as a novel maker for ETR and prognostic prediction, and may be a target for adjuvant therapy of patients with ICC after tumor resection. (Source: International Journal of Surgery)
Source: International Journal of Surgery - January 3, 2013 Category: Surgery Authors: Yu-Ling Chen, Yung-Ming Jeng, Hey-Chi Hsu, Hong-Shiee Lai, Po-Huang Lee, Po-Lin Lai, Ray-Hwang Yuan Tags: Original Research Source Type: research

Systematic review and meta‐analysis of the role of vascular resection in the treatment of hilar cholangiocarcinoma
ConclusionsPortal vein resection does not preclude curative resection; however, it is not routinely recommended unless there is suspicion of tumour invasion. There was no proven survival advantage with portal vein resection. Arterial resection results in higher morbidity and mortality with no proven benefit. (Source: HPB: official journal of the International Hepato Pancreat Biliary Association)
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 1, 2013 Category: Gastroenterology Authors: Saleh Abbas, Charbel Sandroussi Tags: Review Article Source Type: research

A Newly Designed Y-shaped Covered Stent in the Palliative Treatment of Hepatic Hilar Malignant Obstruction: Case Report.
We report a case in an inoperable patient with the hilar malignant biliary obstruction treated palliatively by the use of a newly designed Y-shaped covered stent without interfering contra-lateral bile duct. We percutaneously inserted a newly designed Y-shaped covered stent into a biliary tree in an inoperable patient with Bismuth Type II cholangiocarcinoma. We checked tubograms, enhanced CT studies, and blood bilirubin levels before, one week after, and at every three month after the stenting, by observing closely the signs of clinical infection as well. The follow-up period was about 12 months. The placement of the Y-sha...
Source: Korean J Radiol - January 1, 2013 Category: Radiology Authors: Kang BC, Lee SY, Chung HH Tags: Korean J Radiol Source Type: research

Endoscopic drainage in patients with inoperable hilar cholangiocarcinoma.
Abstract Hilar cholangiocarcinoma has an extremely poor prognosis and is usually diagnosed at an advanced stage. Palliative management plays an important role in the treatment of patients with inoperable hilar cholangiocarcinoma. Surgical, percutaneous, and endoscopic biliary drainage are three modalities available to resolve obstructive jaundice. Plastic stents were widely used in the past; however, self-expanding metal stents (SEMS) have become popular recently due to their long patency and reduced risk of side branch obstruction, and SEMS are now the accepted treatment of choice for hilar cholangiocarcinoma. Bil...
Source: The Korean Journal of Internal Medicine - January 1, 2013 Category: Internal Medicine Authors: Park YJ, Kang DH Tags: Korean J Intern Med Source Type: research

Unrecognized intrahepatic cholangiocarcinoma: an analysis of 993 adult cirrhotic liver explants
Abstract Liver cirrhosis is a recognized risk factor for intrahepatic cholangiocarcinoma (I‐CCa). Small I‐CCa nodules might be undiagnosed or misdiagnosed as hepatocellular carcinoma (HCC) in the context of liver cirrhosis. The aim of this study was to determine the prevalence and clinical impact of undetected I‐CCa in liver explants of adult cirrhotic patients undergoing liver transplantation (LT). From December 1985 to November 2008, a first LT was performed in 993 adult cirrhotic patients in three French academic Hospitals. All liver explants were analyzed for the presence of nodules. The diagnosis of HCC was made...
Source: Clinical Transplantation - January 1, 2013 Category: Transplant Surgery Authors: Mélanie Vallin, Nathalie Sturm, Géraldine Lamblin, Olivier Guillaud, Marie‐Noëlle Hilleret, Valérie Hervieu, Juliette Joubert, Armand Abergel, Vincent Leroy, Olivier Boillot, Jérôme Dumortier, Jean‐Yves Scoazec Tags: Original Article Source Type: research

Incidentally detected cholangiocarcinoma in an explanted liver with biliary atresia after Kasai operation
This report presents the case of a 30‐yr‐old woman with BA who developed incidental cholangiocarcinoma following the Kasai operation. She showed progressive liver dysfunction and cirrhosis at the age of 30 yr and underwent LDLT. A 4‐cm‐diameter liver tumor in the anastomotic site of portoenterostomy was incidentally found as a result of a pathological examination of the explanted native liver. The tumor was pathologically diagnosed to be intrahepatic cholangiocarcinoma. Although cholangiocarcinoma in patients with BA has been previously reported in only three cases, it should be nevertheless always considered in t...
Source: Pediatric Transplantation - December 28, 2012 Category: Transplant Surgery Authors: Akinari Fukuda, Seisuke Sakamoto, Hiroyuki Kanazawa, Takanobu Shigeta, Chiaki Karaki, Ikumi Hamano, Hajime Uchida, Hiroaki Kitagawa, Chiaki Okuse, Osamu Miyazaki, Shunsuke Nosaka, Atsuko Nakazawa, Mureo Kasahara Tags: Case Report Source Type: research

Effectiveness and Safety of Preoperative Percutaneous Transhepatic Cholangiodrainage With Bile Re-infusion in Patients With Hilar Cholangiocarcinoma: A Retrospective Controlled Study.
CONCLUSIONS:: Preoperative PTCD with bile re-infusion improves the resection rate and shows a good safety profile in patients with hilar cholangiocarcinoma. PMID: 23276892 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - December 28, 2012 Category: Journals (General) Authors: Yu FX, Ji SQ, Su LF, Zhang SC, Zhang QY Tags: Am J Med Sci Source Type: research

Is a self-expandable metal stent better than a plastic stent in unresectable complex hilar cholangiocarcinoma with regard to the adequacy of drainage and survival of the patients?
We read with great interest the recent article by Sangchan et al. The authors concluded that endoscopic biliary drainage with a self-expandable metal stent (SEMS) provides better adequacy of drainage and longer survival compared with the plastic stent (PS) in patients with unresectable complex hilar cholangiocarcinoma. It is an interesting study. Nevertheless, several issues seem worthy of comment. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - December 22, 2012 Category: Gastroenterology Authors: Feng Shao, Chen Wang, Lujun Qiu, Qiang Huang, YuanGuo Hu Tags: Letters to the Editor Source Type: research

Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma (Br J Surg 2013; 100: 274-283).
PMID: 23239480 [PubMed - in process] (Source: The British Journal of Surgery)
Source: The British Journal of Surgery - December 22, 2012 Category: Surgery Authors: Gouma DJ Tags: Br J Surg Source Type: research

Cholangiocarcinoma: Are North American Surgical Outcomes Optimal?
Conclusions: This analysis suggests that postoperative outcomes are best for distal and worst for perihilar cholangiocarcinomas, and hepatectomy for bile duct cancers is associated with a 2- to 3-fold mortality risk. We conclude that North American surgical outcomes can be improved for patients with proximal cholangiocarcinomas. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - December 20, 2012 Category: Surgery Authors: Andrew P. Loehrer, Michael G. House, Attila Nakeeb, E. Molly Kilbane, Henry A. Pitt Tags: Original Scientific Articles Source Type: research

Guidelines for Diagnosing and Treating CholangiocarcinomaGuidelines for Diagnosing and Treating Cholangiocarcinoma
What do the very latest guidelines say about the diagnosis of cholangiocarcinoma, and how do they recommend clinicians treat the disease? This new article summarizes. Gut (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 19, 2012 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Gadoxetic acid‐enhanced MRI with MR cholangiography for the preoperative evaluation of bile duct cancer
Conclusion:Gadoxetic acid‐enhanced MRI with MRC is a reliable diagnostic method for assessing the tumor extent and resectability of BDC. J. Magn. Reson. Imaging 2013;. © 2013 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - December 19, 2012 Category: Radiology Authors: Hye Young Sun, Jeong Min Lee, Hee Sun Park, Jeong Hee Yoon, Jee Hyun Baek, Joon Koo Han, Byung Ihn Choi Tags: Original Research Source Type: research