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A systematic review of proton therapy in the treatment of chondrosarcoma of the skull baseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chondrosarcoma (CSA) of the skull base (SB) is an uncommon, slowly growing, neoplasm comprising approximately 0.1% of all intracranial tumors and 6% of SB lesions. Even though its growth is slow, CSA is a potentially lethal tumor. The therapeutic approach to CSA of the SB is still controversial and clinical experience is limited because of the relative rarity of this tumor. The use of proton therapy (PT) after maximal surgery is widely accepted, but there are no controlled studies demonstrating the need of PT and its superiority in comparison to radiotherapy with photons. We conducted a systematic r...
Source: Urosurgical Review - November 17, 2009 Category: Urology & Nephrology Tags: Neurosurgical Review Source Type: journals

Outcome of intralesional curettage for low-grade chondrosarcoma of long bonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intralesional curettage is an effective treatment strategy for low-grade intramedullary chondrosarcoma of long bones, with excellent oncological and functional results. Careful case selection with stringent clinical and radiographic follow-up is recommended. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Authors: S.A. Hanna, P. Whittingham-Jones, M.D. Sewell, R.C. Pollock, J.A. Skinner, A. Saifuddin, A. Flanagan, S.R. Cannon, T.W.R. Briggs Tags: Original Articles Source Type: journals

Fine-needle aspiration cytology of extraskeletal myxoid chondrosarcoma: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a typical case of EMC in left inguinal region of a 71-year-old man, which was first approached by fine-needle aspiration, followed by surgical excision and subsequently diagnosed by microscopic examination and immunohistochemical study. We discuss briefly the differential diagnosis. It is important to separate EMC from other myxoid soft tissue tumors. We point out that although cytologic features may be orientating to a myxoid tumor, may not be completely distinctive. Diagn. Cytopathol. 2010. © 2009 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Juan B. Laforga, Joan M. Gasent Source Type: journals

A Rare Extra-Skeletal Myxoid Chondrosarcoma of the Lower Leg - Is Amputation Absolutely Necessary?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Each persistent soft tissue swelling must be appropriately diagnosed using adequate imaging and even biopsy (in case of a doubtful finding), which should be performed with definitive surgery in mind. PMID: 19890812 [PubMed - as supplied by publisher] (Source: Zentralblatt fur Chirurgie)
Source: Zentralblatt fur Chirurgie - November 4, 2009 Category: Surgery Authors: Mroczkowski P, Evert M, Tautenhahn J, Meyer F, Lippert H Tags: Zentralbl Chir Source Type: journals

Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that BK increased the migration and the expression of [alpha]2[beta]1 integrin in human chondrosarcoma cells. We also found that human chondrosarcoma tissues had significantly higher expression of the B1 and B2 receptors comparing to normal cartilage. BK-mediated migration and integrin up-regulation was attenuated by B1 and B2 BK receptor siRNA or antagonist. Activations of phospholipase C (PLC), protein kinase C[delta] (PKC[delta]), and NF-[kappa]B pathways after BK treatment was demonstrated, and BK-induced integrin expression and migration activity was inhibited by the specific inhibitor of PLC, ...
Source: Journal of Cellular Biochemistry - November 2, 2009 Category: Biochemistry Authors: Wei-Hung Yang, Jung-Tzu Chang, Sheng-Feng Hsu, Te-Mao Li, Der-Yang Cho, Chun-Yin Huang, Yi-Chin Fong, Chih-Hsin Tang Source Type: journals

MR Imaging of Primary Bone Tumors and Tumor-like Conditions in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumorlike conditions encountered in the pediatric population. Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma. Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis. The use of MR imaging in the diagnosis of these lesions is ...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Sandra L. Wootton-Gorges Source Type: journals

MR imaging of primary bone tumors and tumor-like conditions in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article provides a review of the MR imaging features of the major primary malignant and benign bone tumors and tumor-like conditions encountered in the pediatric population. Malignant tumors discussed include osteosarcoma, Ewing sarcoma, chondrosarcoma, lymphoma, and malignant fibrous histiocytoma. Benign lesions discussed include simple bone cysts, aneurysmal bone cysts, giant cell tumor, osteochondroma, enchondroma, chondroblastoma, osteoid osteoma, osteoblastoma, nonossifying fibroma, fibrous dysplasia, osteofibrous dysplasia, hemangioma, and histiocytosis. The use of MR imaging in the diagnosis of these lesions is...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Wootton-Gorges SL Tags: Radiol Clin North Am Source Type: journals

Identification and Characterization of the Human Xylosyltransferase I Gene Promoter Region [Glycobiology and Extracellular Matrices]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human xylosyltransferase I catalyzes the initial and rate-limiting step in the biosynthesis of glycosaminoglycans and proteoglycans. Furthermore, this enzyme has been shown to play a major role in the physiological development of bone and cartilage as well as in pathophysiological processes such as systemic sclerosis, dilated cardiomyopathy, or fibrosis. Here, we report for the first time the identification and characterization of the XYLT1 gene promoter region and important transcription factors involved in its regulation. Members of the activator protein 1 (AP-1) and specificity protein 1 (Sp1) family of transcription fa...
Source: Journal of Biological Chemistry - October 30, 2009 Category: Chemistry Authors: Muller, B., Prante, C., Kleesiek, K., Gotting, C. Tags: Glycobiology and Extracellular Matrices Source Type: journals

PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The differential diagnosis of soft tissue tumours poses a considerable challenge for pathologists, especially adipocytic tumours, as these may show considerable overlap in clinical presentation and morphological features with many other mesenchymal neoplasms. Hence, a specific and reliable marker that identifies adipocytic differentiation is much sought. We investigated the immunohistochemical expression of PIM-1 kinase in 35 samples of soft tissue tumours using tissue microarray technology and 49 full sections of adipocytic (n = 26) and non-adipocytic tumours (n = 23). Benign and malignant adipocytic tumours showed strong...
Source: International Journal of Experimental Pathology - October 28, 2009 Category: Pathology Authors: Min En Nga, Nu Nu Ma Swe, Kang Ting Chen, Liang Shen, Michael B. Lilly, Siew Pang Chan, Manuel Salto-Tellez, Kakoli Das Source Type: journals

Selected Update: Chondrosarcoma: p53 and Gli combine forcesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The GLI2 transcription factor and a loss of p53 cooperate to induce chondrosarcomas by decreasing expression of insulin-like growth factor binding protein 3 (Igfbp3), which upregulates IGF signaling. (Source: Nature Signaling Update)
Source: Nature Signaling Update - October 23, 2009 Category: Research Source Type: info

Erratum to: PATCHED-ONE or SMOOTHENED Gene Mutations Are Infrequent in Chondrosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19847580 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - October 21, 2009 Category: Orthopaedics Authors: Yan T, Angelini M, Alman BA, Andrulis IL, Wunder JS Tags: Clin Orthop Relat Res Source Type: journals

Critical signaling pathways in bone sarcoma: Candidates for therapeutic interventionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Bone sarcomas cause disproportionate morbidity and mortality and desperately need new therapies as there has been little improvement in outcomes in 20 years. Identification of critical signaling pathways, including type 1 insulin-like growth factor receptor (IGF-1R) for Ewing sarcoma and possibly osteosarcoma, and the ERBB and the Wnt signaling pathways for osteosarcoma, have emerged as receptors mediating vital signals for bone sarcoma. Akt, mammalian target of rapamycin (mTOR), phosphoinositide 3-kinases, mitogen-activated protein kinase kinase, extracellular signal-regulated kinases, and Ras path...
Source: Current Oncology Reports - October 13, 2009 Category: Cancer & Oncology Tags: Current Oncology Reports Source Type: journals

Involvement of AdipoR receptor in adiponectin-induced motility and {alpha}2{beta}1 integrin upregulation in human chondrosarcoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed for the first time that adiponectin mediates the migration of human chondrosarcoma cells. One mechanism underlying adiponectin-directed migration was transcriptional upregulation of 2β1 integrin and activation of AdipoR receptor, AMPK, p38 and NF-B pathways. (Source: Carcinogenesis)
Source: Carcinogenesis - October 6, 2009 Category: Cancer & Oncology Authors: Chiu, Y.-C., Shieh, D.-C., Tong, K.-M., Chen, C.-P., Huang, K.-C., Chen, P.-C., Fong, Y.-C., Hsu, H.-C., Tang, C.-H. Tags: CANCER BIOLOGY Source Type: journals

Cricoid chondrosarcoma presenting as breathy dysphonia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19826993 [PubMed - in process] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 30, 2009 Category: ENT & OMF Authors: Rickert S, Buckmire R, Sulica L Tags: Ear Nose Throat J Source Type: journals

Molecular pathology of sarcomas: concepts and clinical implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The molecular genetic changes that have been described in sarcomas over the past era have aided our understanding of their pathogenesis. The majority of sarcomas carry nonspecific genetic changes within a background of a complex karyotype. These constitute the challenges in sarcoma research for unraveling a putative multistep genetic model, such as for chondrosarcoma, and finding targets for therapeutic strategies. Approximately 15–20% of mesenchymal tumors carry a specific translocation within a relatively simple karyotype. The resulting fusion products act either as transcription factors upregul...
Source: Virchows Archiv - September 29, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Extraskeletal myxoid chondrosarcoma: a study using a quick-freezing and deep-etching methodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A case of extraskeletal myxoid chondrosarcoma (ESMC), which developed in the right thigh of a middle-aged Japanese woman, was studied using immunohistochemistry, conventional electron microscopy, and the quick-freezing and deep-etching (QF-DE) method. In addition to typical light microscopic findings of ESMC, conventional electron microscopy indicated that the tumor cells had features of chondrocytes. Immunohistochemically, the tumor cells showed a positive immunoreaction for S100 protein. A diagnosis of ESMC was made. An interesting observation was the ultrastructural features of collagen fibrils i...
Source: Medical Molecular Morphology - September 29, 2009 Category: Molecular Biology Tags: Medical Molecular Morphology Source Type: journals

Clear cell chondrosarcoma: an ultrastructural studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here a case of CCC. A 67-year-old Japanese man presented with right arthralgia for 1 year, and histological examination of the subsequent surgical resection of the right femoral bone showed the finding of CCC. Ultrastructurally, most organelles were observed in the perinuclear area. Clear neoplastic cells contained many glycogen particles in the area of the cytoplasm lacking organelles, although glycogen particles overall seemed to be evenly distributed in the cytoplasm. Some mitochondria, Golgi complex, actin-like filaments, and rough endoplasmic reticulum were also demonstrated in the cytoplasm of clear ce...
Source: Medical Molecular Morphology - September 29, 2009 Category: Molecular Biology Tags: Medical Molecular Morphology Source Type: journals

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, elevated HDAC7 expression in human OA may contribute to cartilage degradation via promoting MMP-13 gene expression, suggesting the critical role of MMP-13 in OA pathogenesis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10165-009-0224-7Authors Reiji Higashiyama, The Scripps Research Institute Division of Arthritis Research 10550 North Torrey Pines Road La Jolla CA 92037 USAShigeru Miyaki, The Scripps Research Institute Division of Arthritis Research 10550 North Torrey Pines Road La Jolla CA 92037 USASatoshi Yamashita, National Research Institute for Child Health and Development Dep...
Source: Modern Rheumatology - September 29, 2009 Category: Rheumatology Tags: Modern Rheumatology Source Type: journals

Molecular characterization of commonly used cell lines for bone tumor research: A trans-European EuroBoNet effortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Usage of cancer cell lines has repeatedly generated conflicting results provoked by differences among subclones or contamination with mycoplasm or other immortal mammalian cells. To overcome these limitations, we decided within the EuroBoNeT consortium to characterize a common set of cell lines including osteosarcomas (OS), Ewing sarcomas (ES), and chondrosarcomas (CS). DNA fingerprinting was used to guarantee the identity of all of the cell lines and to distinguish subclones of osteosarcoma cell line HOS. Screening for homozygous loss of 38 tumor suppressor genes by MLPA revealed deletion of CDKN2A as the most common even...
Source: Genes, Chromosomes and Cancer - September 28, 2009 Category: Cancer & Oncology Authors: Laura Ottaviano, Karl-Ludwig Schaefer, Melanie Gajewski, Wolfgang Huckenbeck, Stefan Baldus, Uwe Rogel, Carlos Mackintosh, Enrique de Alava, Ola Myklebost, Stine H. Kresse, Leonardo A. Meza-Zepeda, Massimo Serra, Anne-Marie Cleton-Jansen, Pancras C. W. Ho Source Type: journals

Chondrosarcoma: p53 and Gli combine forcesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nature Reviews Cancer 9, 688 (2009). doi:10.1038/nrc2741 Author: Sarah Seton-Rogers Enchondromas are benign cartilage tumours found in the metaphyses of bones (the location of growth plates) that can progress to malignant chondrosarcoma. Benjamin Alman and colleagues previously created a mouse model of enchondroma in which Gli2 is expressed in chondrocytes under the control of (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 24, 2009 Category: Cancer & Oncology Authors: Sarah Seton-Rogers Tags: Research Highlight Source Type: journals

Reconstruction of a Massive Femoral Bone Defect Using a Double-barreled Free Vascularized Fibular Bone Graft After Wide Resection of Femoral ChondrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Salvaging the limb after malignant bone tumor ablation is a tough challenge for a reconstructive surgeon confronting such extensive bone defects. A 40-year-old male without any underlying disease was incidentally diagnosed with a chondrosarcoma over ...more (Source: The Kaohsiung Journal of Medical Sciences)
Source: The Kaohsiung Journal of Medical Sciences - September 21, 2009 Category: Universities & Medical Training Source Type: journals

Advanced Osteoarthritis in Humans Is Associated With Altered Collagen VI Expression and Upregulation of ER-stress Markers Grp78 and Bag-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To test the hypothesis that a perturbation of endoplasmic reticulum (ER) function is involved in the pathogenesis of osteoarthritis (OA), articular cartilage was isolated from non-OA patients secondary to resection of osteo- or chondrosarcomas. Intra-joint samples of minimal and advanced osteoarthritic cartilage were isolated from patients undergoing total knee arthroplasty and scored for disease severity. Glucose-regulated protein-78 (grp78) and bcl-2–associated athanogene-1 (bag-1) were detected via immunofluorescence as markers of non-homeostatic ER function. Additionally, the expression of type VI collagen and it...
Source: Journal of Histochemistry and Cytochemistry - September 17, 2009 Category: Biochemistry Authors: Nugent, A. E., Speicher, D. M., Gradisar, I., McBurney, D. L., Baraga, A., Doane, K. J., Horton, W. E. Tags: Articles Source Type: journals

A novel mutated cell line with characteristics of dedifferentiated chondrosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a novel dedifferentiated CS cell line, MS0812, was spontaneously established from mutated human embryonic muscle cells. Several features of the cell line were investigated, including growth characteristics, cytogenetics, electron microscopic features, expression of various antigenic markers and tumor formation. MS0812 has been cultured continuously for more than 3 years. The growth characteristics of MS0812 are similar to the immortalized cell lines as reported. The cell line exhibited complex karyotypes and hyperploidy, the chromosome number ranged from 50 to 158. MS0812 was positive for vimentin, desmin an...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Yang L, Chen Q, Zhang S, Wang X, Li W, Wen J, Huang X, Zheng J, Huang G, Huang T, Ju G Tags: Int J Mol Med Source Type: journals

Chondrosarcoma of the hand: radiologic evaluation at early stageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we present a patient with chondrosarcoma originating from the second metacarpal bone, whose radiograph taken by chance 2 years prior to his admission revealed the initial manifestation of the tumor. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00590-009-0544-5Authors Kenichiro Hamada, Osaka University Graduate School of Medicine Departments of Orthopaedic Surgery 2-2, Yamadaoka Suita, Osaka 565-0871 JapanYasuhiko Tomita, Osaka Medical Center for Cancer and Cardiovascular Diseases Department of Pathology 1-3-3, Nakamichi, Higasinari-ku Osaka 537-8511 JapanTakafumi Ueda, Osaka Nati...
Source: European Journal of Orthopaedic Surgery & Traumatology - September 3, 2009 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: journals

Vascular reconstruction in lower limb musculoskeletal tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These cases are a challenge to the clinicians, radiologists and pathologists. Review by a multidisciplinary team can produce successful results with low post-operative morbidity and mortality. Longer follow-up is required to determine the long-term implications. (Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - August 30, 2009 Category: Surgery Authors: J. Ian Spark, Peter Charalabidis, Peter Laws, Ruben Seben, Mark Clayer Tags: ORIGINAL ARTICLES Source Type: journals

Surgical Treatment of Grade I Central Chondrosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The grade of chondrosarcoma relates to the likelihood of local recurrence and metastases. Many Grade I chondrosarcomas behave benignly if aggressively, and the question arises regarding whether wide resection is essential to control the disease. We therefore asked whether intralesional surgery also could be extended to Grade I chondrosarcomas without an increase in recurrence. We retrospectively reviewed 31 patients with Grade I chondrosarcomas of the limbs. The minimum followup was 66 months (mean, 157 months; range, 66-296 months). None of the 16 patients treated by resection had recurrences during the followup and t...
Source: Clinical Orthopaedics and Related Research - August 28, 2009 Category: Orthopaedics Authors: Donati D, Colangeli S, Colangeli M, Di Bella C, Bertoni F Tags: Clin Orthop Relat Res Source Type: journals

Rho iso-alpha acids from hops inhibit the GSK-3/NF-kappaB pathway and reduce inflammatory markers associated with bone and cartilage degradationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: RIAA may have potential as an anti-inflammatory therapeutic. (Source: Journal of Inflammation)
Source: Journal of Inflammation - August 26, 2009 Category: Drugs & Pharmacology Authors: Veera Reddy KondaAnuradha DesaiGary DarlandJeffrey BlandMatthew Tripp Source Type: journals

Chondrosarcoma of the nasal septum: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Chondrosarcoma make up only 10–20% of malignant primary bone tumors, with 5–10% located in the head and neck (Downey TJ, Clark SK, Moore DW. Chondrosarcoma of the nasal septum. Otolaryngol Head Neck Surg 2001;125:98–100), and nasal septal chondrosarcoma is extremely rare. Surgical excision is the only curative treatment and radiation and chemotherapy have a limited role for palliation. We used a navigation system in endoscopic surgery without complications for a case of chondrosarcoma of the nasal septum by means of a midfacial degloving approach at primary operation and an external incision approach at sal...
Source: Auris, Nasus, Larynx - August 21, 2009 Category: ENT & OMF Authors: Kazuyuki Kainuma, Kiminori Netsu, Kenji Asamura, Keiko Hayashi, Yutaka Takumi, Hiroyoshi Ota, Shin-ichi Usami Tags: Case reports Source Type: journals

Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: As ephrins have been associated with tumorigenesis and tumor progression, we investigated ephrin-A5 (EFNA5) expression in specimens of normal cartilage and chondrosarcomas of different grade by conventional and quantitative reverse transcription polymerase chain reaction (RT-PCR), Western blot, and immunohistochemistry. We detected a significant EFNA5 down-regulation in chondrosarcomas compared with normal cartilage using quantitative RT-PCR (P < .05). The results were confirmed by Western blot and immunohistochemistry. We did not detect any causative genetic or epigenetic alterations in EFNA5 promoter methylation...
Source: Human Pathology - August 20, 2009 Category: Pathology Authors: Thomas Kalinski, Albrecht Röpke, Saadettin Sel, Irina Kouznetsova, Martin Röpke, Albert Roessner Tags: Original Contributions Source Type: journals

Biopsy can determinate tumoral track contamination: A case report of chondrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: In order to get a correct diagnosis, biopsy is fundamental in oncological orthopedic surgery. If for other tumors, like liver and lung, the possibility to spread malignant cells through biopsy track is well known, it was less evident for bone tumors. This case report study focuses this problem; radiologists and orthopedics have to maintain a high suspicion level while checking post-biopsy imaging. Recurrence can be considered a negative prognostic factor for outcome patients. (Source: European Journal of Radiology Extra)
Source: European Journal of Radiology Extra - August 13, 2009 Category: Radiology Authors: Carmine Zoccali, Umberto Prencipe, Fabio Erba, Antonello Vidiri, Franco Di Filippo Source Type: journals

Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CCL5 (previously called RANTES) was originally recognized as a product of activated T cells, and plays a crucial role in the migration and metastasis of human cancer cells. It has been reported that the effect of CCL5 is mediated via CCR receptors. We found that human chondrosarcoma tissues had significant expression of the CCL5 and CCR5, which was higher than that in normal cartilage. We also found CCL5 increased the migration and matrix metalloproteinases-3 (MMP)-3 expression in human chondrosarcoma cells (JJ012 cells). In addition, MMP-3 small interfering RNA and inhibitor inhibited the CCL5-induced cell migration. ...
Source: Biochemical Pharmacology - August 10, 2009 Category: Drugs & Pharmacology Authors: Tang CH, Yamamoto A, Lin YT, Fong YC, Tan TW Tags: Biochem Pharmacol Source Type: journals

High-grade chondrosarcoma mimicking Brodie's abscessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The “penumbra sign” on unenhanced T1-weighted (T1W), spin-echo (SE) magnetic resonance imaging (MRI) is a well-recognized and characteristic finding in subacute osteomyelitis. The description of the penumbra sign was originally published by Grey et al. in 1998. The penumbra sign is considered to be an extremely helpful discriminator between subacute musculoskeletal infection and tumour. This sign describes a rim lining an abscess cavity with higher SI than that of the main abscess on T1W SE images. In a recent study, the average specificity and sensitivity of the penumbra sign for musculoskeletal infection has been re...
Source: Clinical Radiology - August 7, 2009 Category: Radiology Authors: A. Datir, S. Lidder, R. Pollock, R. Tirabosco, A. Saifuddin Tags: Case Reports Source Type: journals

HDAC4 Represses Vascular Endothelial Growth Factor Expression in Chondrosarcoma by Modulating RUNX2 Activity [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chondrosarcoma is a primary bone tumor with a dismal prognosis; most patients with this disease develop fatal pulmonary metastases, suggesting the need for a better systemic treatment. Anti-angiogenesis treatment may be useful, because angiogenesis is critical for both tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is the most potent pro-angiogenic factor and is regulated by pathways related to the normal physiologic response to hypoxia and genetic alterations related to the malignant phenotype. Our prior work has shown that VEGF is overexpressed in high grade chondrosarcoma and chondrosarcoma cell ...
Source: Journal of Biological Chemistry - August 6, 2009 Category: Chemistry Authors: Sun, X., Wei, L., Chen, Q., Terek, R. M. Tags: Mechanisms Of Signal Transduction Source Type: journals

Gli2 and p53 Cooperate to Regulate IGFBP-3- Mediated Chondrocyte Apoptosis in the Progression from Benign to Malignant Cartilage TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Louisa Ho, Aneta Stojanovski, Heather Whetstone, Qing Xia Wei, Elaine Mau, Jay S. Wunder, Benjamin Alman. Clinical evidence suggests that benign cartilage lesions can progress to malignant chondrosarcoma, but the molecular events in this progression are unknown. Mice that develop benign cartilage lesi.... (Source: Cancer Cell)
Source: Cancer Cell - August 4, 2009 Category: Cancer & Oncology Source Type: journals

Compressive Osseointegration of Tibial Implants in Primary Cancer Reconstruction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Compressive osseointegration technology, which provides immediate, mechanically compliant endoprosthetic fixation, has been adapted for massive proximal tibial reconstructions in an attempt to avoid aseptic failure encountered with conventional stems. A retrospective review of 16 patients with resected tumors was undertaken to determine whether compressive osseointegration can provide durable anchorage of tibial implants. Medical records, radiographs, and clinical examinations were reviewed to assess surgical, local disease control, and prosthetic outcomes. The average age was 18 years (range, 12-42 years). Diagnoses i...
Source: Clinical Orthopaedics and Related Research - August 3, 2009 Category: Orthopaedics Authors: O'Donnell RJ Tags: Clin Orthop Relat Res Source Type: journals

Kinome Profiling of Chondrosarcoma Reveals Src-Pathway Activity and Dasatinib as Option for TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, using kinome profiling, we found the Src pathway to be active in chondrosarcoma. Moreover, we showed in vitro that the inhibitor of the Src pathway, dasatinib, may provide a potential therapeutic benefit for chondrosarcoma patients who are not eligible for surgery. [Cancer Res 2009;69(15):6216–22] (Source: Cancer Research)
Source: Cancer Research - July 28, 2009 Category: Cancer & Oncology Authors: Schrage, Y. M., Briaire-de Bruijn, I. H., de Miranda, N. F.C.C., van Oosterwijk, J., Taminiau, A. H.M., van Wezel, T., Hogendoorn, P. C.W., Bovee, J. V.M.G. Tags: Experimental Therapeutics, Molecular Targets, and Chemical Biology Source Type: journals

All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to elucidate the mechanism of cartilage degradation in osteoarthritis (OA), we established a cell assay system. Under the stimulation of all-trans retinoic acid (ATRA), the human chondrosarcoma cell line HCS-2/8 increased proteoglycan release from inactivated bovine nasal cartilage (BNC) and the results suggested the involvement of membrane-bound metalloproteinase(s). Therefore, we focused on the induction of a disintegrin and metalloproteinase (ADAM) superfamily upon ATRA stimulation. Of all ADAMs tested, only ADAM28 was induced by ATRA in HCS-2/8 cells and also in human primary chondrocytes. We found that tr...
Source: Biochemical and Biophysical Research communications - July 28, 2009 Category: Biochemistry Authors: Hikichi Y, Yoshimura K, Takigawa M Tags: Biochem Biophys Res Commun Source Type: journals

Primary Chondrosarcoma of the KidneyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Urol Int 2009;83:116-118 (DOI:10.1159/000224880) (Source: Karger Publishers)
Source: Karger Publishers - July 27, 2009 Category: Cancer & Oncology Source Type: journals

Complete transurethral bladder eversion 3 months after hemipelvectomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the first reported case of bladder eversion after hemipelvectomy and propose possible pathophysiologic mechanisms. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00192-009-0950-6Authors Gregory Lowe, The Ohio State University Medical Center Department of Urology 3620 Cramblett Hall, 456 West 10th Avenue Columbus OH 43210 USASubbarao Mandalapu, The Ohio State University Medical Center Department of Urology 3620 Cramblett Hall, 456 West 10th Avenue Columbus OH 43210 USAJason Gilleran, The Ohio State University Medical Center Department of Urology 3128 Cramblett Hall, 456 West 10th Avenue Columb...
Source: International Urogynecology Journal - July 25, 2009 Category: OBGYN Tags: International Urogynecology Journal Source Type: journals

[Recurrent synovial chondromatosis of the tarsometatarsal joint : Case report and review of literature.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case report of a 32-year-old male with synovial chondromatosis in the tarsometatarsal joint area, which is an uncommon localization. PMID: 19629422 [PubMed - as supplied by publisher] (Source: Der Unfallchirurg)
Source: Der Unfallchirurg - July 23, 2009 Category: Orthopaedics Authors: Köhler T, Kellermann S, Kipke K, Fruth R, Dahlen C Tags: Unfallchirurg Source Type: journals

Characterization and regulation of ADAMTS-16.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we ascertained that the full length ADAMTS16 mRNA was expressed in chondrocytes and cloned the appropriate cDNA. Stable over-expression of ADAMTS16 in chondrosarcoma cells led to a decrease in cell proliferation and migration, though not adhesion, as well as a decrease in the expression of matrix metalloproteinase-13 (MMP13). The transcription start point of the human ADAMTS16 gene was experimentally identified as 138bp upstream of the translation start ATG and the basal promoter was mapped out to -1802bp. Overexpression of Egr1 induced ADAMTS16 promoter constructs of -157/+138 or longer whilst Sp1 induced a...
Source: Matrix Biology - July 23, 2009 Category: Molecular Biology Authors: Surridge AK, Rodgers UR, Swingler TE, Davidson RK, Kevorkian L, Norton R, Waters JG, Goldring MB, Parker AE, Clark IM Tags: Matrix Biol Source Type: journals

Mesenchymal chondrosarcoma of the orbit: an unusual site for a rare tumourEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a 22-year old man with such disease, together with details of his management. A brief literature review of this uncommon tumour was also enclosed. (Source: European Journal of Cancer Care)
Source: European Journal of Cancer Care - July 19, 2009 Category: Cancer & Oncology Authors: A.R.A. RAZAK, L. GURNEY, N. KIRKHAM, D. LEE, C. NEOH, M. VERRILL Source Type: journals

Genome profiling of chondrosarcoma using oligonucleotide array-based comparative genomic hybridizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Chondrosarcomas of the bone are malignant hyaline cartilage-forming tumors with an annual incidence rate of 3.6% of all primary bone malignancies in the United States. Specimens of 25 chondrosarcomas (10 grade I, 9 grade II, 1 grade III, and 5 dedifferentiated) from 23 patients were collected from the Department of Pathology at the University Hospital at UMDNJ-New Jersey Medical School from 1996 to 2007. Array-based comparative genomic hybridization (array-CGH) studies were performed on frozen tumor specimens. Recurrent deletions observed in at least in six tumors were 5q13.2, 5q14.2∼q21.3, 6q12∼q13, 6q16∼...
Source: Cancer Genetics and Cytogenetics - July 14, 2009 Category: Genetics & Stem Cells Authors: Meera Hameed, Celal Ulger, Duygu Yasar, Neha Limaye, Rohini Kurvathi, Deanna Streck, Joseph Benevenia, Francis Patterson, James J. Dermody, Gokce A. Toruner Tags: Lead article Source Type: journals

Kinome Profiling of Chondrosarcoma Reveals Src-Pathway Activity and Dasatinib as Option for Treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, using kinome profiling, we found the Src pathway to be active in chondrosarcoma. Moreover, we showed in vitro that the inhibitor of the Src pathway, dasatinib, may provide a potential therapeutic benefit for chondrosarcoma patients who are not eligible for surgery. [Cancer Res 2009;69(15):OF1-7]. PMID: 19602594 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - July 13, 2009 Category: Cytology Authors: Schrage YM, Briaire-de Bruijn IH, de Miranda NF, van Oosterwijk J, Taminiau AH, van Wezel T, Hogendoorn PC, Bovée JV Tags: Cancer Res Source Type: journals

Head and neck chondrosarcoma: Analysis of 16 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Early diagnosis and adequate surgical resection are important to get better survival rates. (Source: The British Journal of Oral & Maxillofacial Surgery)
Source: The British Journal of Oral & Maxillofacial Surgery - July 7, 2009 Category: ENT & OMF Authors: Fabio Ornellas Prado, Inês Nobuko Nishimoto, Danyel Elias da Cruz Perez, Luiz Paulo Kowalski, Márcio Ajudarte Lopes Tags: Leading Article Source Type: journals

Metastatic intraocular chondrosarcoma in a dogEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chondrosarcoma accounts for about 10% of all canine bone tumors and is the second most common primary bone tumor in dogs. In veterinary medicine, chondrosarcomas are classified as skeletal and extraskeletal. Extraskeletal chondrosarcomas are mesenchymal neoplasms of soft tissues and visceral organs that produce neoplastic chondrocytes in a fibrillary matrix. There is no involvement of bone or periosteal tissues in extraskeletal chondrosarcomas. The aim of this report is to describe the first case of a metastatic intraocular extraskeletal chondrosarcoma in a dog. (Source: Veterinary Ophthalmology)
Source: Veterinary Ophthalmology - July 5, 2009 Category: Veterinary Research Authors: Emilio F. Rodrigues Jr, Alexandre P. Ribeiro, Eduardo Perlmann, Dennis E. Brooks, José Luiz Laus Tags: Case Reports Source Type: journals

Trans-articular chondrosarcoma grade 2 of proximal phalanx resulting in its fracture along with destruction of middle phalanx of 2nd toe right foot: a case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of Grade 2 chondrosarcoma of proximal phalanx resulting in its fracture along with transarticular extension to the middle phalanx of the 2nd toe of right foot in a 62 year old female. The patient presented with 1 and 1/2 year history of pain and swelling in right 2nd toe. X-ray showed presence of expanding lytic lesion with amorphous calcification along with fracture proximal phalanx. Fine needle aspiration cytology showed some pleomorphs, osteoclasts and some giant cells. We went for amputation of toe without a biopsy. Histopathological examination of specimen showed multiple pleomorphic cells, nuclear at...
Source: Cases Journal - July 5, 2009 Category: Journals (General) Source Type: journals

Dedifferentiated peripheral chondrosarcomas: regulation of EXT-downstream molecules and differentiation-related genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Pancras CW Hogendoorn (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - July 3, 2009 Category: Pathology Authors: Leida B RozemanInge H Briaire de BruijnPatrizia BacchiniEric L StaalsFranco BertoniJudith V M G BovéePancras CW Hogendoorn Source Type: journals

Supraclavicular extraskeletal myxoid chondrosarcoma presenting with a sensorimotor polyneuropathy associated with anti-Hu antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of a 49-year-old man with anti-Hu syndrome in the setting of an extraskeletal myxoid chondrosarcoma. This case shows the importance of searching for antineural antibodies in oncologic patients with new neurologic deficits, and of having a judicious workup for occult malignancies in patients with known antineural antibodies. PMID: 19711588 [PubMed - in process] (Source: Oncology (Williston Park, N.Y.))
Source: Oncology (Williston Park, N.Y.) - June 30, 2009 Category: Cancer & Oncology Authors: Deik A, Azizi E, Shapira I, Boniece IR Tags: Oncology (Williston Park) Source Type: journals