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[Cervical chordomas.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19914595 [PubMed - as supplied by publisher] (Source: Acta Otorrinolaringologica Espanola)
Source: Acta Otorrinolaringologica Espanola - November 13, 2009 Category: ENT & OMF Authors: Rosell Ferrer R, Aguilà Artal A, Escamilla Carpintero Y Tags: Acta Otorrinolaringol Esp Source Type: journals

An interesting diagnosis for a presacral mass: Case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present an unusual cause of a presacral mass being extramedullary haematopoiesis, found incidentally in a 71 year old female. Extramedullary haematopoiesis is defined as the production of myeloid and erythroid elements outside of the bone-marrow. This diagnosis is extremely rare in the presacral area especially in a patient with no haematological abnormalities. A review of the literature is presented. (Source: International Seminars in Surgical Oncology)
Source: International Seminars in Surgical Oncology - November 8, 2009 Category: Surgery Authors: Sina BabazadehMatthew BroadheadJohn SlavinPeter Choong Source Type: journals

Chordoma masquerading as a nerve root tumour -- a clinical lesson.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of cervical chordoma masquerading radiologically as an extracranial nerve sheath tumour. A laterally situated chordoma (centred extra-osseously in the neural foramen) was diagnosed radiologically as a neurofibroma pre-operatively. We review the key radiological features for diagnosis of chordoma. We consider the importance of pre-operative diagnosis of chordoma in guiding management and in determining survival. PMID: 19890117 [PubMed - in process] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - November 1, 2009 Category: Radiology Authors: Brennan PM, Summers DM, Ironside J, Fitzpatrick MO Tags: Br J Radiol Source Type: journals

Isolated petroclival craniopharyngioma with aggressive skull base destruction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a rare case of petroclival craniopharyngioma with no connection to the sellar or suprasellar region. MRI and CT images revealed a homogenously enhancing retroclival solid mass with aggressive skull base destruction, mimicking chordoma or aggressive sarcoma. However, there was no calcification or cystic change found in the mass. Here, we report the clinical features and radiographic investigation of this uncommon craniopharyngioma arising primarily in the petroclival region. PMID: 19881982 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 31, 2009 Category: Universities & Medical Training Authors: Lee YH, Kim SD, Lim DJ, Park JY, Chung YG, Kim YS Tags: Yonsei Med J Source Type: journals

PIM-1 kinase expression in adipocytic neoplasms: diagnostic and biological implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The differential diagnosis of soft tissue tumours poses a considerable challenge for pathologists, especially adipocytic tumours, as these may show considerable overlap in clinical presentation and morphological features with many other mesenchymal neoplasms. Hence, a specific and reliable marker that identifies adipocytic differentiation is much sought. We investigated the immunohistochemical expression of PIM-1 kinase in 35 samples of soft tissue tumours using tissue microarray technology and 49 full sections of adipocytic (n = 26) and non-adipocytic tumours (n = 23). Benign and malignant adipocytic tumours showed strong...
Source: International Journal of Experimental Pathology - October 28, 2009 Category: Pathology Authors: Min En Nga, Nu Nu Ma Swe, Kang Ting Chen, Liang Shen, Michael B. Lilly, Siew Pang Chan, Manuel Salto-Tellez, Kakoli Das Source Type: journals

Fusarium oxysporum infection of stasis ulcer: eradication with measures aimed to improve stasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fusarium species may cause localised skin infections in immunocompetent individuals. At least half of these infections are preceded by skin breakdown. The lesions are characterised by slow progression and good response to therapy. Here we present a 60-year-old non-diabetic man with stasis ulcers showing Fusarium oxysporum growth in culture of both pus swabs and skin biopsy specimens. The patient was confined to wheelchair because of recurrent sacral chordoma of 15 years duration, which was not under treatment for the last 3 years. Leg ulcers were resistant to antifungal therapy, and healed rapidly after improving of stasis...
Source: Mycoses - October 28, 2009 Category: Research Authors: A. Tülin Mansur, Seza Artunkal, Beyza Ener Source Type: journals

Response to imatinib plus sirolimus in advanced chordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In addition to PDGFRB, mTOR pathway can be activated in chordomas and the combination of IM plus rapalogs may be effective in IM-resistant chordomas. (Source: Annals of Oncology)
Source: Annals of Oncology - October 27, 2009 Category: Cancer & Oncology Authors: Stacchiotti, S., Marrari, A., Tamborini, E., Palassini, E., Virdis, E., Messina, A., Crippa, F., Morosi, C., Gronchi, A., Pilotti, S., Casali, P. G. Tags: sarcomas Source Type: journals

Reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase-9 are prognostic markers in skull base chordomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Prognosis of chordomas is difficult to predict based solely on histological findings. The purpose of this study was to assess expressions of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and matrix metalloproteinase (MMP)-2, MMP-9 in skull base chordomas and to find out their correlations to outcome. Immunohistochemical study was performed in 19 samples (initial, n = 11; recurrent, n = 8) from 11 patients. The correlations among expression of RECK, MMP-2, MMP-9, and their prognostic values were analyzed. Significant correlation between RECK and MMP-9 was found, but there ...
Source: Urosurgical Review - October 27, 2009 Category: Urology & Nephrology Tags: Neurosurgical Review Source Type: journals

Chordoma of the Mobile Spine and Sacrum: A Retrospective Analysis of a Series of Patients Surgically Treated at Two Referral CentersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Tumor size and surgical margins affected outcome only on initial presentation. However, wide surgery was feasible in a minority of cases. Most patients died of local–regional disease even when metastases occurred. Indeed, long-term prognosis was such that disease-free survival at 10 years was only 26%. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0740-xAuthors Silvia Stacchiotti, Istituto Nazionale Tumori Department of Cancer Medicine Milan ItalyPaolo Giovanni Casali, Istituto Nazionale Tumori Department of Cancer Medicine Milan ItalySalva...
Source: Annals of Surgical Oncology - October 22, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Gene Duplication Identified in an Uncommon Form of Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
: Scientists discover that a familial form of a rare bone cancer called chordoma is explained not by typical types of changes or mutations in the sequence of DNA in a gene, but rather by the presence of a second copy of an entire gene. The findings appeared online Oct. 4, 2009, in Nature Genetics and was done by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues. NHGRI researcher David Ng co-authored the study. (Source: NHGRI-Related News)
Source: NHGRI-Related News - October 21, 2009 Category: Genetics & Stem Cells Source Type: news

Scientists Find Cause Of Familial ChordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DURHAM, N.C. -- U.S. scientists say they've found a genetic alteration is the cause of familial chordoma, an uncommon bone cancer that also affects the nervous system. Duke University Medical Center and National Cancer Institute researchers said the genetic alteration -- a second copy of an entire gene -- produces inherited differences in gene copy number, known as copy number variation, that have been implicated in some hereditary diseases. "This alteration is unlike anything we have ever seen before in families that tend to develop the same kind of cancers," said Dr. Michael Kelley, an associate professor at Duke Univers...
Source: Cancercompass News: Other Cancer - October 19, 2009 Category: Cancer & Oncology Source Type: news

Long-term control of clival chordoma with initial aggressive surgical resection and gamma knife radiosurgery for recurrenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Long-term control of clival chordomas was achieved. Recurrent tumors were controlled with gamma knife radiosurgery, since lesions were localized and small after initial aggressive resection. The MIB-1 labeling index can provide important information for predicting tumor recurrence. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0535-7Authors Eiji Ito, Fukushima Medical University Department of Neurosurgery 1 Hikarigaoka Fukushima 960-1295 JapanKiyoshi Saito, Fukushima Medical University Department of Neurosurgery 1 Hikarigaoka Fukushima 960-1295 JapanTakeshi Oka...
Source: Acta Neurochirurgica - October 13, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Posterior transpedicular corpectomy for malignant cervical spine tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The goal of this study was to assess surgical clinical and radiographic outcomes of using a posterior transpedicular approach (posterolateral) for ventral malignant tumors of the cervical spine. Access to ventral lesions of the cervical spine can be challenging in patients with malignant tumors. Anterior approaches are the gold standard for ventral pathology in the cervical spine, however, there are cases, where a posterior approach is indicated due to multilevel disease, previous radiation, swallowing difficulty with difficulty in retraction of trachea and esophagus, and in cases where circumferent...
Source: European Spine Journal - October 13, 2009 Category: Orthopaedics Tags: European Spine Journal Source Type: journals

Gene Duplication Identified in an Uncommon Form of Bone CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have discovered that a familial form of a rare bone cancer called chordoma is explained not by typical types of changes or mutations in the sequence of DNA in a gene, but rather by the presence of a second copy of an entire gene. Inherited large structural changes, known as copy number variations (CNVs), have been implicated in some hereditary diseases but have seldom been reported as the underlying basis for a familial cancer. This finding appeared online Oct. 4, 2009, in Nature Genetics and was done by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their coll...
Source: National Institutes of Health (NIH) News Releases - October 8, 2009 Category: American Health Source Type: news

New Type Of Genetic Change Identified In Inherited CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration - a second copy of an entire gene - is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 7, 2009 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Scientists Find Cause Of Familial ChordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
U.S. scientists say they've found a genetic alteration is the cause of familial chordoma, an uncommon bone cancer that also affects the nervous system. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - October 6, 2009 Category: Cancer & Oncology Source Type: news

New Type Of Genetic Change Identified In Inherited CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scientists have discovered that a novel genetic alteration -- a second copy of an entire gene -- is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 5, 2009 Category: Science Source Type: news

New type of genetic change identified in inherited cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Duke University Medical Center) Duke University Medical Center and National Cancer Institute scientists have discovered that a novel genetic alteration -- a second copy of an entire gene -- is a cause of familial chordoma, an uncommon form of cancer arising in bones and frequently affecting the nervous system. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 4, 2009 Category: Global & Universal Source Type: news

T (brachyury) gene duplication confers major susceptibility to familial chordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
mp; Michael J Kelley Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, which is important in notochord development and is expressed in most sporadic chordomas. Our findings highlight the value of screening for complex genomic rearrangements in searches for cancer-susceptibility genes. (Source: Nature Genetics)
Source: Nature Genetics - October 4, 2009 Category: Genetics & Stem Cells Authors: Xiaohong R YangDavid NgDavid A AlcortaNorbert J LiebschEamonn SheridanSufeng LiAlisa M GoldsteinDilys M ParryMichael J Kelley Tags: Brief Communication Source Type: journals

Chordoma of the Lumbar Spine Presenting as Sciatica and Treated with VertebroplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The lumbar spine is a less common location for chordoma. Here we describe a 44-year-old woman presenting with pain due to a L4 vertebral expansile lesion that caused significant canal stenosis and neural foraminal compromise. Vertebroplasty was performed and resulted in immediate pain relief. For patients with painful lumbar chordoma who are unwilling to undergo surgery, vertebroplasty can play a palliative role as in patients with other vertebral lesions. Treating pain and stabilizing vertebra by way of vertebroplasty in a case of chordoma has not yet been reported. Content Type Journal ArticleC...
Source: CardioVascular and Interventional Radiology - September 19, 2009 Category: Radiology Tags: CardioVascular and Interventional Radiology Source Type: journals

Best Cases from the AFIP: Sacral Chordoma [AFIP Archives]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Radiographics recent issues)
Source: Radiographics recent issues - September 14, 2009 Category: Radiology Authors: Farsad, K., Kattapuram, S. V., Sacknoff, R., Ono, J., Nielsen, G. P. Tags: Musculoskeletal Radiology, Neuroradiology, Oncologic Imaging AFIP Archives Source Type: journals

[Extracranial stereotactic radiotherapy avancer by robotic radiosurgery: preliminary experience of the center Alexis-Vautrin.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotactic radiotherapy delivers allows for a highly precise irradiation, and was originally developed in the 70s by neurosurgeons. Gradually, it has been developed in extracranial indications. Moreover new innovative treatment devices such as the robotic radiosurgery with CyberKnife(R) have emerged. Indications are currently being validated by the HAS in intracranial locations that are treated by conventional radiosurgery for several decades. Three robotic radiosurgery facilities were opened in France in 2006 thanks to a grant from the INCa. Those are posed in Lille, Nice, Nancy. Since 2007, 140 patients were treate...
Source: Bulletin du Cancer - September 13, 2009 Category: Cancer & Oncology Authors: Taste H, Beckendorf V, Bernier V, Graff P, Marchesi V, Noël A, Peiffert D Tags: Bull Cancer Source Type: journals

Spontaneous cerebrospinal fluid rhinorrhea: A rare initial presentation of clival chordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hsieh Cheng-Ta, Liu Ming-Ying, Su Wan-Fu, Ju Da-TongNeurology India 2009 57(4):513-514 (Source: Neurology India)
Source: Neurology India - September 10, 2009 Category: Neurology Authors: Hsieh Cheng-Ta, Liu Ming-Ying, Su Wan-Fu, Ju Da-Tong Source Type: journals

[Current indications and ongoing clinical trials with CyberKnife (R) stereotactic radiotherapy in France in 2009.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Image-guided frameless fractionated stereotactic radiotherapy can be performed with millimetric accuracy using the CyberKnife(R) (Accuray Inc. Sunnyvale, USA) equipped with an integrated tracking system for intra- and extracranial lesions. Highly conformal hypofractionated irradiation has been used to treat lesions with curative or palliative intent. It is advantageous for radioresistant tumors, re-irradiating lesions, boosting small volumes and treating tumors that move with respiration. It also limits travel costs and improves the quality of life. Over 60,000 patients have been treated worldwide using CyberKnife(R) i...
Source: Bulletin du Cancer - September 7, 2009 Category: Cancer & Oncology Authors: Thariat J, Li G, Angellier G, Marchal S, Palamini G, Rucka G, Bénézery K, Castelli J, Trimaud R, Mammar H, Marcie S, Gérard JP, Bondiau PY Tags: Bull Cancer Source Type: journals

A combined posterior, lateral, and anterior approach to ventrolaterally situated chordoma of the upper cervical spineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: When a direct posterior approach makes it difficult or impossible to reach tumors extending to the far lateral margins of the spine and soft tissues, the posterior-lateral approach described here allows excellent visualization and safe access with minimal neural retraction for treating these laterally situated lesions. We describe the surgical technique for a combined approach as an alternative to the direct posterior or anterior retropharyngeal approach. (Source: Surgical Neurology)
Source: Surgical Neurology - September 7, 2009 Category: Neurosurgery Authors: Seung-Jae Hyun, Seung-Chul Rhim, K. Daniel Riew Tags: Neoplasm Source Type: journals

CommentaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chordomas in the high cervical region are difficult to manage from a resection point of view. The authors have correctly highlighted the need for several approaches to excise the lesion and provide for stability. The vertebral artery is always a major factor in the resection and may sometimes have to be sacrificed. (Source: Surgical Neurology)
Source: Surgical Neurology - September 7, 2009 Category: Neurosurgery Authors: Arnold H. Menezes Tags: Neoplasm Source Type: journals

The presence and absence of lymphatic vessels in the adult human intervertebral disc: relation to disc pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our findings indicate that lymphatic vessels are not present in the normal adult intervertebral disc but that, when there is extrusion of disc material into surrounding soft tissue, there is ingrowth of reparative fibrous tissue containing lymphatic vessels. Our findings also indicate that chordoma, a tumour of notochordal origin, spreads to regional lymph nodes via lymphatics in para-spinal soft tissues. Content Type Journal ArticleCategory Scientific ArticleDOI 10.1007/s00256-009-0770-2Authors Karolina Kliskey, University of Oxford Nuffield Department of Orthopaedic, Rheumatology and Mu...
Source: Skeletal Radiology - September 3, 2009 Category: Radiology Tags: Skeletal Radiology Source Type: journals

Staged sacrectomy-an adaptive approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Sacrectomy, a dreaded operation that often results in morbidity, is now feasible with modifications and improvement in surgical technique. The staged abdominosacral approach reduces the immediate postoperative morbidity. Use of a gluteal advancement flap reduces the incidence of wound complications. With modern surgical facilities and postoperative care, sacrectomy is feasible via the staged abdominosacral approach. PMID: 19769509 [PubMed - in process] (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - August 31, 2009 Category: Neurosurgery Authors: Ramamurthy R, Bose JC, Muthusamy V, Natarajan M, Kunjithapatham D Tags: J Neurosurg Spine Source Type: journals

En bloc resection of primary tumors of the cervical spine: report of two cases and systematic review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this systematic review of the literature, en bloc resection provided good disease-free survival rates in patients with primary tumors of the cervical spine. However, there are insufficient data on long-term subjective outcomes in these patients, and larger series are needed to determine the efficacy compared with piecemeal resection techniques. Other investigators should be encouraged to publish their results so that combined analyses like these may be performed with larger sample sizes. (Source: The Spine Journal)
Source: The Spine Journal - August 31, 2009 Category: Orthopaedics Authors: Jordan M. Cloyd, Dean Chou, Vedat Deviren, Christopher P. Ames Tags: Review Articles Source Type: journals

Endoscopic endonasal transclival resection of chordomas: operative technique, clinical outcome, and review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The endonasal endoscopic transclival approach represents a less invasive and more direct approach than a transcranial approach to treat certain moderate-sized midline skull base chordomas. Longer follow-up is necessary to determine comparability to transcranial approaches for long-term control. Large tumors with significant extension lateral to the carotid artery may not be suitable for this approach. PMID: 19698043 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - August 20, 2009 Category: Neurosurgery Authors: Fraser JF, Nyquist GG, Moore N, Anand VK, Schwartz TH Tags: J Neurosurg Source Type: journals

Modified transoral approach for resection of skull base chordomas in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This approach allows for good access to the skull base region to allow for maximal tumour resection. This technique also appears to have minimal impact on palatal function and no adverse effects on the upper airway management. Content Type Journal ArticleCategory Technical NoteDOI 10.1007/s00381-009-0955-yAuthors Xenia Doorenbosch, Women’s and Children’s Hospital Department of Neurosurgery 72 King William Rd North Adelaide South Australia 5006 AustraliaStephen Santoreneos, Women’s and Children’s Hospital Department of Neurosurgery 72 King William Rd North Adelaide South Australia 500...
Source: Child's Nervous System - July 30, 2009 Category: Pediatrics Tags: Child's Nervous System Source Type: journals

Review of current treatment of sacral chordomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chordoma is a relatively rare, locally aggressive tumor which is known to arise from embryonic remnants of the notochord and to occur exclusively along the spinal axis, with a predilection for the sacrum. Although chordoma typically presents as a single lesion, a few cases of metastasis have been reported and the prognosis of such patients may be poor. Chordomas are slowly growing tumors with insidious onset of symptoms, making early diagnosis difficult. Recent improvements in imaging have provided valuable information for early diagnosis. The optimal treatment for sacral chordoma is en bloc sacral resection with wide surg...
Source: Orthopaedic Surgery - July 26, 2009 Category: Orthopaedics Authors: Kang-wu Chen, Hui-lin Yang, Yugandhar Kandimalla, Jia-yong Liu, Gen-lin Wang Tags: Review Article Source Type: journals

Occlusion of the Abdominal Aorta by Balloon Dilation Catheter Assisting Surgical Excision of a Sacrum Chordoma: Case Report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chordoma is known to be the most common primary tumor of the sacrum. Its surgery is challenging from many aspects. A large amount of bleeding is one of the biggest issues. A 52-year-old woman was admitted to our clinic with a huge mass at sacrum. The mass was diagnosed as chordoma after a needle biopsy. Prior to the surgery, a balloon dilation catheter (BDC) was placed in the distal abdominal aorta via the femoral artery. Just after the skin incision, the BDC was inflated with contrast medium and total occlusion of the aorta was achieved. At the end of the operation we observed that total hemorrhage had decreased drama...
Source: Turkish Neurosurgery - July 23, 2009 Category: Neurosurgery Authors: Ozgıray E, Cağli S, Zılelı M, Cinar C, Oran I Tags: Turk Neurosurg Source Type: journals

Prognostic factors of sacral chordoma after surgical therapy: a study of 36 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& X Q Chen (Source: Spinal Cord)
Source: Spinal Cord - July 20, 2009 Category: Research Authors: K W ChenH L YangJ LuJ Y LiuX Q Chen Source Type: journals

Clivus Chordoma: Is It Enough to Image the Primary Site?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Skull BaseDOI: 10.1055/s-0029-1225533ABSTRACTChordomas are rare malignant tumors arising from embryonic remnants of the primitive notochord, around which the skull base and vertebral column develop. They are locally aggressive but metastasize rarely. To our knowledge, this is the first reported case of synchronous intraosseous chordomas. A 32-year-old man presented with intermittent double vision secondary to a right-side abducent nerve palsy. Imaging revealed a clivus chordoma and an asymptomatic synchronous second primary chordoma in the fifth lumbar vertebra. Both chordomas were surgically excised: the clivus using the ...
Source: Skull Base - July 11, 2009 Category: ENT & OMF Tags: CASE REPORT Source Type: journals

A case of unilateral hypoglossus nerve palsy associated with chordoma in the region of clivusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We had a rare case of 50-year-old woman with a unilateral hypoglossus nerve palsy as a sign of clival chordoma. A computed tomography (CT) scan of the skull base showed bone destruction at the anterior part of the foramen magnum and CT scan of the neck reveals asymmetrical area at the base of the tongue. Magnetic resonance imaging showed a mass at the skull base in the region of the clivus with bone destruction in the middle and right side of the clivus. The tumor was biopsied through transnasal biopsy from the region of the clivus using a navigation system and microscopical surgical technique. Post...
Source: European Archives of Oto-Rhino-Laryngology - July 10, 2009 Category: ENT & OMF Tags: European Archives of Oto-Rhino-Laryngology Source Type: journals

Intradural clival chordoma: a rare pathological entityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present one such case of a clival intradural chordoma who presented with a left trigeminal nerve sensory neuropathy. The lesion was totally excised uneventfully via a retromastoid suboccipital approach. There was no recurrence of the lesion at 1-year follow-up. Characteristics of intradural chordoma and its close differential ecchordosis physaliphora are reviewed in this article. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s11060-009-9949-6Authors D. I. Bhat, National Institute of Mental Health & Neurosciences Department of Neurosurgery Bangalore 560 029 IndiaM. Yasha, National Institute of Menta...
Source: Journal of Neuro-Oncology - July 6, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

One-Staged Subtotal Sacrectomy for Primary Sacral TumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions One-staged sacrectomy can be safely performed, obtaining the satisfactory outcomes. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0570-xAuthors Chucheep Sahakitrungruang, Chulalongkorn University Colorectal Surgery Division, Department of Surgery Bangkok ThailandKraisri Chantra, Chulalongkorn University Neurological Surgery Division, Department of Surgery Bangkok Thailand Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - June 30, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Chondromyxoid Fibroma of Sphenoid Sinus with Unusual Calcifications: Case Report with Literature ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report one case of CMF involving the sphenoid sinus mimicking a chondrosarcoma. The tumor mass showed calcifications on images and histology. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s12105-009-0121-6Authors Luc G. T. Morris, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 USAJordan Rihani, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 USARichard A. Lebowitz, New York University School of Medicine Department of Otolaryngology 550 First Avenue, HCC-3C New York NY 10016 U...
Source: Head and Neck Pathology - June 10, 2009 Category: Pathology Tags: Head and Neck Pathology Source Type: journals

[Sacral chordoma: A rare tumour of the buttocks.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 62-year-old patient presenting a bulky tumefaction, nodular in places, not very painful, and extending towards the anal area, scrotum and the posterior aspect of the upper left thigh. Histopathological examination of a macrobiopsy sample of this tumefaction pointed to chordoma. On magnetic resonance imaging (MRI), the tumour presented multiple ramifications extending towards the scrotal area, the sciatic area and the posterior aspect of the left thigh. Palliative tumorectomy was performed. Given the very slow progression of the tumour and the risk of adverse effects in such a large tumoral exposure ...
Source: Annales de Dermatologie et de Cenereologie - May 31, 2009 Category: Dermatology Authors: Guirat A, Affes N, Boujlbene S, Abbes K, Gouiaa N, Daoud H, Issam Beyrouti M Tags: Ann Dermatol Venereol Source Type: journals

A rare case of intraosseous benign notochordal cell tumor of the coccyx.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article presents a case of a 53-year-old woman who presented with intermittent, dull, poorly localized lower back and buttock pain. The pain worsened in a seated position or after long periods of standing. A T1-weighted magnetic resonance image (MRI) of the sacrum and coccyx revealed a well-demarcated intraosseous lesion with homogeneous low signal intensity, while T2-weighted MRIs demonstrated homogeneous high signal intensity. An excisional biopsy revealed benign notochord cell tumor. The biopsy proved to be effective, as it relieved the patient's coccydynia. Due to the rarity of intraosseous benign notochordal cell...
Source: Orthopedics - May 31, 2009 Category: Orthopaedics Authors: Uglialoro AD, Beebe KS, Hameed M, Benevenia J Tags: Orthopedics Source Type: journals

Presacral Tumors: Diagnosis and ManagementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinics in Colon and Rectal Surgery 2009; 22: 084-093DOI: 10.1055/s-0029-1223839ABSTRACTPresacral tumors are uncommon lesions that can be difficult to diagnose because of their nonspecific presenting signs and symptoms. Cross-sectional imaging is essential in evaluating these lesions to determine the optimal surgical approach and the extent of resection. Surgery is the mainstay of treatment as it establishes the diagnosis and prevents the adverse consequences associated with malignant degeneration and secondary bacterial infection. The outcomes for patients with benign presacral tumors are favorable. Although there have be...
Source: Clinics in Colon and Rectal Surgery - May 28, 2009 Category: Surgery Source Type: journals

Pulmonary vein metastasis of a sacral chordoma extending into the left atrial cavity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 557DOI: 10.2459/JCM.0b013e32832bca61Authors: Prompona, Maria a; Linn, Jennifer b; Burdorf, Lars c; Assmann, Gerald d; Reichart, Bruno c; Reiser, Maximilian a; Nikolaou, Konstantin a (Source: Journal of Cardiovascular Medicine)
Source: Journal of Cardiovascular Medicine - May 27, 2009 Category: Cardiology Tags: Abstract HTML PDF (157 K) Source Type: journals

Emisacrectomy, experience in 11 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Emisacrectomy is a challenging surgery in the treatment of tumours that affect the sacrum. Authors report their experience in 11 cases affected by tumours of the sacrum (9 chordomas, 1 ependymoma, 1 monostotic bladder metastasis) operated on at the Orthopaedic Department of A.S.O S. Giovanni Battista Molinette in Turin, Italy, from 1998 through 2005 discussing planning surgery, level of osteotomy, functional and oncological results and complications of the treatment at a median follow-up of 5 years (range 2–9), describing the surgical and medical teaching learned from the treatment of these p...
Source: European Spine Journal - May 26, 2009 Category: Orthopaedics Tags: European Spine Journal Source Type: journals

Oronasopharyngeal chordomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00701-009-0303-8Authors Jeroen R. Coppens, University of Utah Department of Neurosurgery Salt Lake UT 84132 USAH. Ric Harnsberger, University of Utah Department of Radiology Salt Lake UT 84132 USAMichael A. Finn, University of Utah Department of Neurosurgery Salt Lake UT 84132 USAPramod Sharma, Ear, Nose, and Throat Center Salt Lake UT 84102-1307 USAWilliam T. Couldwell, University of Utah Department of Neurosurgery Salt Lake UT 84132 USA Journal Acta NeurochirurgicaOnline ISSN 0942-0940Print ISSN 0001-6268 (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - May 26, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Comparison of cytological features of myxopapillary ependymomas on crush preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Myxopapillary ependymoma (ME) is a rare neoplasm found predominantly in the sacro-coccygeal region in adults and is characterized by its distinct epithelial and stromal components. From 1990 to April 2008, a total of 10 ME cases were recorded at our institution. Six out of 10 cases underwent frozen section examination with concomitant crush preparations, which forms the basis of this study. The clinical and cytologic findings in all six cases were reviewed. There were four males and two females. The age ranges from 15 to 36 years with a mean age of 27 years. The epithelial component of ME is strikingly similar for all six ...
Source: Diagnostic Cytopathology - May 20, 2009 Category: Pathology Authors: Dawn P. Bradly, Vijaya B. Reddy, Elizabeth Cochran, Paolo Gattuso Source Type: journals

[CT and MRI of intrinsic space-occupying lesions of the bony skull base.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article gives an overview of the appearance of the most common primary bony skull base masses in CT and MRI. From the authors' point of view these are fibrous dysplasia, chordomas, chondrosarcomas, Langerhans cell histiocytosis and multiple myelomas, which must be differentiated from pseudolesions. The possibilities of CT and MRI in making a specific diagnosis, differential diagnosis and the kind of making the final diagnosis are described. PMID: 19436984 [PubMed - as supplied by publisher] (Source: Der Radiologe)
Source: Der Radiologe - May 13, 2009 Category: Radiology Authors: Kösling S, Neumann K, Brandt S Tags: Radiologe Source Type: journals

Skull base chordomas: efficacy of surgery followed by carbon ion radiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Surgical removal of the tumour around the brainstem and the optic nerve combined with post-operative carbon ion radiotherapy will improve the survival rate and quality of life of patients with complicated skull base chordomas. Content Type Journal ArticleCategory Clinical ArticleDOI 10.1007/s00701-009-0383-5Authors Satoshi Takahashi, Keio University School of Medicine Department of Neurosurgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 JapanTakeshi Kawase, Keio University School of Medicine Department of Neurosurgery 35 Shinanomachi, Shinjuku-ku Tokyo 160-8582 JapanKazunari Yoshida, Keio ...
Source: Acta Neurochirurgica - May 12, 2009 Category: Neurology Tags: Acta Neurochirurgica Source Type: journals

Neuronavigational guidance in craniofacial approaches for large (para)nasal tumors involving the anterior skull base and upper clival lesionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Craniofacial approaches with intraoperative neuronavigational guidance in a multidisciplinary setting allow safe resection of large tumors of the upper clivus and the paranasal sinuses involving the anterior skull base. Complex skull base surgery with the involvement of bony structures appears to be an ideal field for advanced navigation techniques given the lack of intraoperative shift of relevant structures. (Source: European Journal of Surgical Oncology)
Source: European Journal of Surgical Oncology - May 10, 2009 Category: Cancer & Oncology Authors: M. Nakamura, T. Stöver, T. Rodt, O. Majdani, M. Lorenz, T. Lenarz, J.K. Krauss Tags: Original Articles Source Type: journals