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Trophoblastic Neoplasms Express Fatty Acid Synthase, Which May Be a Therapeutic Target via Its Inhibitor, C93.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we analyzed the expression of FASN in normal and molar placentas, as well as gestational trophoblastic neoplasia, and assessed the effects of a new FASN inhibitor, C93, on cellular proliferation and apoptosis in choriocarcinoma cells. Using a FASN-specific monoclonal antibody, we found that FASN immunoreactivity was detected in the cytotrophoblast and intermediate (extravillous) trophoblast of normal and molar placentas, as well as in placental site nodules. All choriocarcinomas (n = 33), 90% of epithelioid trophoblastic tumors (n = 20), and 60% of placental site trophoblastic tumors (n = 10) exhibited FASN ...
Source: The American Journal of Pathology - November 5, 2009 Category: Pathology Authors: Ueda SM, Mao TL, Kuhajda FP, Vasoontara C, Giuntoli RL, Bristow RE, Kurman RJ, Shih IM Tags: Am J Pathol Source Type: journals

Gastric choriocarcinoma admixed with an alpha-fetoprotein-producing adenocarcinoma and separated adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of gastric choriocarcinoma admixed with an alpha-fetoprotein (AFP)-producing adenocarcinoma. A 70-year-old man was hospitalized for gastric cancer that was detected during screening by esophagogastroduodenoscopy (EGD). Initial laboratory data showed the increased serum level of AFP and EGD revealed a 5-cm ulcerofungating mass in the greater curvature of the gastric antrum. The patient underwent radical subtotal gastrectomy with D2 lymph node dissection and Billroth II gastrojejunostomy. Histopathological evaluation confirmed double primary gastric cancer: gastric choriocarcinoma admixed with an AFP-produci...
Source: World Journal of Gastroenterology : WJG - October 28, 2009 Category: Gastroenterology Authors: Eom BW, Jung SY, Yoon H, Kook MC, Ryu KW, Lee JH, Kim YW Tags: World J Gastroenterol Source Type: journals

Primary Retroperitoneal Lymph Node Dissection in Patients With Clinical Stage IS Testis CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Patients with clinical stage IS are at significant risk for metastatic disease and can be successfully treated with primary retroperitoneal lymph node dissection, thereby sparing chemotherapy in most of them. Retroperitoneal recurrence is essentially eliminated when retroperitoneal lymph node dissection is performed in this select patient group. (Source: The Journal of Urology)
Source: The Journal of Urology - October 16, 2009 Category: Urology & Nephrology Authors: Stephen B. Williams, Graeme S. Steele, Jerome P. Richie Tags: Oncology: Prostate/Testis/Penis/Urethra Source Type: journals

Metastasis associated lung adenocarcinoma transcript 1 is up-regulated in placenta previa increta/percreta and strongly associated with trophoblast-like cell invasion in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, annealing control primer–polymerase chain reaction (ACP–PCR) was used to identify differentially expressed genes, which may impair placentation resulting in placenta previa I/P. Placental tissues from I/P and non-increta/percreta (non-I/P) sites were concomitantly collected from patients undergoing Cesarean hysterectomy. After ACP–PCR experiments (three patients), the differentially expressed bands, consistently showing up- or down-regulated trends between each of the I/P and non-I/P tissue pairs, were cloned and sequenced. Human non-protein coding metastasis associated lung adenocarcinoma ...
Source: Molecular Human Reproduction - October 15, 2009 Category: Molecular Biology Authors: Tseng, J.-J., Hsieh, Y.-T., Hsu, S.-L., Chou, M.-M. Tags: Original Research Source Type: journals

Expression of vascular endothelial growth factor (VEGF), hypoxia inducible factor 1 alpha (HIF-1alpha), and transforming growth factors beta1 (TGFbeta1) and beta3 (TGFbeta3) in gestational trophoblastic disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to investigate the relationship between the expression of vascular endothelial growth factor (VEGF), transforming growth factor beta (TGF-beta1 and TGF-beta3), and hypoxia inducible factor 1 alpha (HIF-1alpha) in gestational trophoblastic diseases to highlight the possible histogenesis. Twenty-one partial hydatidiform moles (PHM), 19 complete hydatidiform moles (CHM), 13 choriocarcinomas, and 20 nonhydropic spontaneous abortions (control group) were evaluated with immunohistochemistry using VEGF, HIF-1alpha, TGFbeta1, and TGFbeta3. The extent of immunohistochemical positivity (0%=0, 1-24%=1, 2...
Source: Pathology, Research and Practice - October 13, 2009 Category: Pathology Authors: Bolat F, Haberal N, Tunali N, Aslan E, Bal N, Tuncer I Tags: Pathol Res Pract Source Type: journals

Coexistent gastric primary choriocarcinoma and adenocarcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Choriocarcinomas are commonly gestational and intrauterine or gonadal in origin. Nongestational and extragonadal disease, especially in the stomach is extremely rare with a poorer prognosis and early metastasis. We herein describe a case of primary gastric choriocarcinoma with liver metastasis in a 69-year-old male. The patient presented with abdominal pain and irregular bowel habits of one month duration. Both endoscopic and radiographic imaging revealed an ulcerated and necrotic circumferential tumor in the pyloric antrum of the stomach. The histopathologic findings of the resected tumor were that of an extensively n...
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Pai MR, Mathai AM, Kumar S, Prabhu S Tags: Indian J Pathol Microbiol Source Type: journals

Chromosome territories, X;Y translocation and Premature Ovarian Failure: is there a relationship?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The peculiar clinical case come to our attention highlighted the complexity of POF aetiology and of the translocation event, even if our results seem to exclude any effect on nuclear organisation. POF phenotype could be partially explained by skewed X chromosome inactivation that influences gene expression. (Source: BioMed Central)
Source: BioMed Central - September 26, 2009 Category: Journals (General) Authors: Sara LissoniSimona BaronchelliNicoletta VillaValeria LucchiniEnrico BetriPietro CavalliLeda Dalpra Source Type: journals

Bilateral renal and jejunal metastasis of choriocarcinoma presenting as spontaneous renal hemorrhage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of SRH and episodic gross hematuria in a patient with metastatic choriocarcinoma involving both kidneys for which successful angioembolization was carried out for control of hemorrhage. There was no evidence of primary uterine tumor and pulmonary or liver involvement. The patient developed gastrointestinal bleeding due to jejunal metastasis while on chemotherapy and surgical resection of the involved segment was carried. However, the patient acquired nosocomial pneumonia and succumbed to sepsis in the postoperative period. PMID: 19770094 [PubMed - in process] (Source: Cancer Imaging)
Source: Cancer Imaging - September 25, 2009 Category: Radiology Authors: Lal A, Singhal M, Kumar S, Bag S, Singh SK, Khandelwal N Tags: Cancer Imaging Source Type: journals

Choriocarcinoma with arterial and venous thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cyriac Sanju, Sagar T G, Mahajan VandanaNeurology India 2009 57(4):505-507 (Source: Neurology India)
Source: Neurology India - September 10, 2009 Category: Neurology Authors: Cyriac Sanju, Sagar T G, Mahajan Vandana Source Type: journals

Genetic and Epigenetic Control of the Major Histocompatibility Complex Class Ib Gene HLA-G in Trophoblast Cell LinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The transcriptional regulation of the major histocompatibility complex class (MHC) Ib gene HLA-G differs from the classical MHC class I genes. The cis-acting regulatory elements typical for classical MHC class I promoters are divergent in the promoter of HLA-G, rendering this gene unresponsive to NF-[kappa]B, IRF-1, and class II transactivator (CIITA)-mediated activation pathways. However, as we have previously shown, transactivation of HLA-G is regulated by CREB-1. Because CREB-1 is ubiquitously expressed, this observation does not explain the tissue-restricted expression of HLA-G in extravillous cytotrophoblasts. Using H...
Source: Annals of the New York Academy of Sciences - August 31, 2009 Category: Science Authors: Tjadine M. Holling, Marloes W.T. Bergevoet, Rutger J. Wierda, Marja C.J.A. van Eggermond, Peter J. van den Elsen Tags: Part III. Genetic Considerations and Autoimmune Susceptibility Source Type: journals

Interleukin-11 increases invasiveness of JEG-3 choriocarcinoma cells by modulating STAT3 expressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, activation and upregulation of STAT3 appears to be critical for the IL-11-mediated increase in invasiveness of JEG-3 cells. (Source: Journal of Reproductive Immunology)
Source: Journal of Reproductive Immunology - August 24, 2009 Category: Allergy & Immunology Authors: Pankaj Suman, Tobias G. Poehlmann, Golla Jaya Prakash, Udo R. Markert, Satish K. Gupta Tags: Basic Immunology Source Type: journals

CD9 regulates a transcription factor hGCMa and SYNCYTIN-1 expression through a signaling pathway cAMP/PKA.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, regulatory mechanisms of SYNCYTIN-1 expression were studied using human choriocarcinoma BeWo cells. Forskolin is an activator of adenylate cyclase, which increased CD9 and SYNCYTIN-1 expression. The increase in CD9 expression was inhibited by a protein kinase A (PKA) inhibitor, Rp-cAMPS. These results indicate that CD9 expression is regulated by the cAMP/PKA signaling pathway. Over-expression of CD9 increased expression levels of SYNCYTIN-1 as well as hGCMa, which is a transcription factor known to activate SYNCYTIN-1 gene transcription. However, high SYNCYTIN-1 expression induced by CD9 over-expression did ...
Source: Reproduction - August 18, 2009 Category: Reproduction Medicine Authors: Muroi Y, Sakurai T, Hanashi A, Kubota K, Nagaoka K, Imakawa K Tags: Reproduction Source Type: journals

Inhibition of ERK1/2 does not affect LIF-induced STAT3 ser727 phosphorylation in trophoblastic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
RAS/MAPK is an intracellular signalling pathway, which is involved in the regulation of various cellular processes including proliferation and invasion in numerous cell types. ERK1/2 which is a member of this pathway, has been described controversially to interfere with signal transducer and activator of transcription 3 (STAT3) activation by phosphorylation of its serine residue. STAT3 is major inducer of trophoblast invasiveness. It has been demonstrated that Leukemia Inhibitory Factor (LIF) induces RAS and STAT3 activation. Here we have tested effects of LIF on ERK1/2 and STAT3 ser727 phosphorylation in trophoblastic cel...
Source: Journal of Reproductive Immunology - August 18, 2009 Category: Allergy & Immunology Authors: D.M. Morales, U.R. Markert Tags: 7th European Congress on Reproductive Immunology Source Type: journals

Impact on the expression of the retinoid X receptor α in trophoblast tumor cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retinoid X receptor α (RXRα) is a nuclear hormone receptor which forms heterodimers with peroxisome proliferator activated receptors (PPAR). Enhanced expression of RXRα has been observed in miscarried placentas whereas in hydatidiform mole RXRα expression was down-regulated. The aim of the study was to investigate the impact of the retinoids 9-cis- and all-trans-retinoic acid as well as the impact of the PPARγ agonist 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) on the expression of RXRα on the basis of immunocytochemical methods. The choriocarcinoma cell lines JEG-3 and BeWo which express RXRα were stimulated with ...
Source: Journal of Reproductive Immunology - August 18, 2009 Category: Allergy & Immunology Authors: A. Pestka, B. Toth, Ch. Scholz, Ch. Kuhn, A. Makriagianakis, U. Jeschke Tags: 7th European Congress on Reproductive Immunology Source Type: journals

Cobalt-mimicked oxygen stress-induced expression of HLA-E and HLA-G in JEG-3 choriocarcinoma cells is mediated by HIF-1αEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The non-classical Major Histocompatibility Complex (MHC) molecules HLA-G and HLA-E are selectively expressed by human cytotrophoblasts during human placental development, and they are presumed to be involved in functionally modulating the immune system at the fetal-maternal interface. These non-classical MHC molecules are also expressed by JEG-3 choriocarcinoma cells. Because hypoxia is accepted as a condition accompanying human placenta development during the first trimester, we hypothesized that Cobalt-mimicked oxygen stress could induce the expression of HLA-E and HLA-G in the choriocarcinoma JEG-3 cell line through acc...
Source: Journal of Reproductive Immunology - August 18, 2009 Category: Allergy & Immunology Authors: C.A. Piedrahita-Ochoa, J.C. Bueno, A.P. Cadavid, J.G. Maldonado-Estrada Tags: 7th European Congress on Reproductive Immunology Source Type: journals

SOCS and PIAS: potential negative intracellular regulators of trophoblast invasionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Signal Transducer and Activator of Transcription 3, STAT3, amongst others, is responsible for the invasiveness of trophoblast cells and their malignant derivates, such as human choriocarcinoma cells. Constitutive expression and activation of STAT3 could be correlated to the invasive potential of these cells. The up-regulation of STAT3 through supplementation of Jeg-3 choriocarcinoma cell line cultures with the cytokine leukaemia inhibitory factor, LIF, leads to an altered protease profile, and ultimately, to an elevated proliferation and invasion rate. Finally, the effect of STAT3 knock-down via siRNA (short interference R...
Source: Journal of Reproductive Immunology - August 18, 2009 Category: Allergy & Immunology Authors: U.R. Markert Tags: 7th European Congress on Reproductive Immunology Source Type: journals

Activation of β-Catenin Signalling Increases StarD7 Gene Expression in JEG-3 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: StarD7 gene encodes a protein that belongs to the StAR-related lipid transfer proteins involved in intracellular transport and metabolism of lipids. It has been previously documented that StarD7 has a wide-spread mRNA expression in trophoblastic tissues and several tumour cell lines with highest levels in both choriocarcinoma JEG-3 and JAR cells, hepatocellular carcinoma HepG2, and colorectal adenocarcinoma HT-29 cells. To understand the molecular mechanisms that regulate the expression of the human StarD7 gene, we have cloned and characterized the 5′-flanking region of the gene. Transient transfections of seve...
Source: Placenta - August 16, 2009 Category: Reproduction Medicine Authors: V. Rena, S. Angeletti, G. Panzetta-Dutari, S. Genti-Raimondi Tags: Gene Expression Source Type: journals

Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, genetic alterations occurring in extragonadal choriocarcinoma in two Japanese male patients were examined. Loss of heterozygosity (LOH) analysis using a polymorphic marker of the PTEN gene, IVS4+109ins/delTCTTA, revealed a hemizygous deletion of PTEN not only in the primary gastric choriocarcinoma, but also in the gastric adenocarcinoma. Microsatellite marker D12S1051 likewise showed LOH in both the primary gastric choriocarcinoma and the gastric adenocarcinoma. Mutational analysis of the TP53 gene revealed a point mutation in exon 5 (A536G), which resulted in H179R in the gastric choriocarcinoma but not in ...
Source: Cancer Genetics and Cytogenetics - August 8, 2009 Category: Genetics & Stem Cells Authors: Genshu Tate, Takao Suzuki, Hiroshi Nemoto, Koji Kishimoto, Kenji Hibi, Toshiyuki Mitsuya Tags: Short communications Source Type: journals

Uncommon mucosal metastases to the stomachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: While the accurate recognition of these lesions at endoscopy is fraught with difficulty, pathological awareness of such uncommon metastases in the gastric mucosa is essential for accurate diagnosis and optimal patient management. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - August 2, 2009 Category: Cancer & Oncology Authors: R KanthanK SharanowskiJ SengerF JenniferR ChibbarSc Kanthan Source Type: journals

Molecular Genetic Analyses of ChoriocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Microsatellite polymorphism analysis is a molecular approach for distinguishing the non-gestational choriocarcinoma from the gestational one, and can also be used to identify the causative pregnancy of gestational choriocarcinoma. Antecedent pregnancy prior to choriocarcinoma is not always its causative pregnancy. Therefore, it is reasonable to identify the causative pregnancy by its genetic origin, instead of clinical impression. (Source: Placenta)
Source: Placenta - August 2, 2009 Category: Reproduction Medicine Authors: J. Zhao, Y. Xiang, X.R. Wan, F.Z. Feng, Q.C. Cui, X.Y. Yang Tags: choriocarcinoma Source Type: journals

Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human ADAM19 is a recently identified member of the ADAM family. It is highly expressed in human placentas, but its dynamic change and function at the human feto-maternal interface during placentation remain to be elucidated. In this present study, the spatial and temporal expression and cellular localization of ADAM19 in normal human placentas were first demonstrated, and the effects of ADAM19 on trophoblast cell adhesion and invasion were further investigated by using a human choriocarcinoma cell line (JEG-3) as an in vitro model. The data demonstrated that ADAM19 was widely distributed in villous cytotrophoblast cel...
Source: Science in China. Series C, Life Sciences - July 31, 2009 Category: Science Authors: Zhao M, Qiu W, Li Y, Sang QA, Wang Y Tags: Sci China C Life Sci Source Type: journals

Aurora B expression in post-puberal testicular germ cell tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have evaluated by immunohistochemical analysis Aurora B expression in post-puberal testicular germ cell tumours (22 seminomas, 2 teratomas, 15 embryonal carcinomas, 5 mixed germinal tumours with a prominent yolk sac tumour component and 1 choriocarcinoma). The Aurora B protein expression was detected in all intratubular germ cell tumours, seminomas and embryonal carcinomas analysed but not in teratomas and yolk sac carcinomas. The immunohistochemical data were further confirmed by Western blot analysis. In addition, the kinase Aurora B was vigorously expressed in GC-1 cells line derived from murine sperma...
Source: Journal of Cellular Physiology - July 21, 2009 Category: Cytology Authors: Francesco Esposito, Silvana Libertini, Renato Franco, Antonella Abagnale, Luigi Marra, Giuseppe Portella, Paolo Chieffi Source Type: journals

Ablation of Stat3 by siRNA Alters Gene Expression Profiles in JEG-3 Cells: A Systems Biology ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Control of inflammation at the maternal–fetal interface is a critical element in mammalian pregnancy. Previous work from our laboratory has shown that Stat3 may be a placental mediator involved in maintaining immunologic homeostasis at the maternal–fetal interface. The aim of the current study is to further elucidate the role of Stat3 in response to inflammation. As ablation of Stat3 in mice results in embryonic lethality, we evaluated the role of Stat3 in vitro using an siRNA approach.Trophoblast-like JEG-3 cells were transfected with an siRNA construct specific to Stat3. Experimental and control cells were ...
Source: Placenta - July 20, 2009 Category: Reproduction Medicine Authors: K. Jiang, L.C. Krous, N. Knowlton, Y. Chen, M.B. Frank, C. Cadwell, M. Centola, J.N. Jarvis Tags: choriocarcinoma Source Type: journals

MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MyD88 and TRIF exert direct regulatory effect on cAMP-induced CRH promoter activation in JEG3 cells in the absence of infection. MyD88 most likely interacts with molecules upstream of IRAK2 to regulate cAMP-induced CRH expression. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - July 16, 2009 Category: Endocrinology Authors: Andy UhCharles SimmonsCatherine BreseeNasif KhouryAdrian GombartRichard NicholsonHande KocakOzlem Equils Source Type: journals

Gestational Choriocarcinoma in One Placenta of Dichorionic Diamniotic Twins who Showed Severe AnemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gestational choriocarcinoma occurs in one in 20,000–40,000 pregnancies . Choriocarcinoma cases during singleton pregnancy have been reported. However, choriocarcinoma in the placenta of an anemic fetus in twin pregnancy has not yet been reported. We accidentally discovered a choriocarcinoma focus in one placenta of dichorionic diamniotic twins who showed severe anemia. (Source: Placenta)
Source: Placenta - July 15, 2009 Category: Reproduction Medicine Authors: A. Shiozaki, N. Yoneda, S. Yoneda, Y. Soeda, T. Hamashima, S. Ishizawa, K. Tamura, S. Horikawa, H. Higashiyama, T. Yoshida, T. Miyawaki, S. Saito Tags: Letter to the Editors Source Type: journals

Involvement of GATA transcription factors in the regulation of endogenous bovine interferon-Tau gene transcriptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, DNA microarray/RT-PCR analysis between bovine trophoblast CT-1 and Mardin-Darby bovine kidney (MDBK) cells was initially performed, finding that transcription factors GATA2, GATA3, and GATA6 mRNAs were specific to CT-1 cells. These mRNAs were also found in Days 17, 20, and 22 (Day 0 = day of estrus) bovine conceptuses. In examining other bovine cell lines, ovary cumulus granulosa (oCG) and ear fibroblast (EF) cells, GATA2 and GATA3, but not GATA6, were found specific to the bovine trophoblast cells. In transient transfection analyses using the upstream region (-631 to +59 bp) of bovine IFNT gene (bIFNT, IFN-...
Source: Molecular Reproduction and Development - July 13, 2009 Category: Reproduction Medicine Authors: Hanako Bai, Toshihiro Sakurai, Min-Su Kim, Yoshikage Muroi, Atsushi Ideta, Yoshito Aoyagi, Hiromi Nakajima, Masashi Takahashi, Kentaro Nagaoka, Kazuhiko Imakawa Source Type: journals

Management of primary intracranial germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Primary intracranial germ cell tumors are rare and usually localized in the pineal and the suprasellar regions. They are divided into the following histologic types: germinoma, teratoma (mature, immature, malignant), choriocarcinoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), and mixed tumors. Clinically, they are manifested with ocular signs or signs of obstructive hydrocephalus. Localized germinomas are treated with radiation therapy and exhibit a relatively good prognosis. Chemotherapy is reserved for disseminated germinomas. Mature teratomas are treated with surgery. The rest ...
Source: Journal of Neuro-Oncology - July 9, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

The protein-tyrosine phosphatase, shp-2, is a crucial mediator of exogenous igf signalling to human trophoblast.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates a role for tyrosine phosphatases in human trophoblast and establishes SHP-2 as a component of the IGF signalling pathway that is required for normal placental growth. PMID: 19589868 [PubMed - as supplied by publisher] (Source: Endocrinology)
Source: Endocrinology - July 8, 2009 Category: Endocrinology Authors: Forbes K, West G, Garside R, Aplin JD, Westwood M Tags: Endocrinology Source Type: journals

Induction of Cells Differentiation and ABC Transporters Expression by a Myco-Estrogen, Zearalenone, in Human Choriocarcinoma Cell Line (BeWo).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The mycotoxin zearalenone, produced by Fusarium species, is a worldwide contaminant of concern in cereals and other plant products. Due to its estrogenic activity, zearalenone (ZEA) is known to have toxicological effect in animals on reproductive system and the placental transfer of ZEA was suggested by in vivo studies. Although passive diffusion is the principal transport mechanism across the placenta, several carrier-mediated transport protein such as ABC transporter (P-gp, MRP1, MRP2, BCRP) have been identified in the placenta. In this work, we have investigated the effect of ZEA on trophoblast differentiation and A...
Source: Toxicology - July 2, 2009 Category: Toxicology Authors: Prouillac C, Videmann B, Mazallon M, Lecoeur S Tags: Toxicology Source Type: journals

Stimulating the GPR30 Estrogen Receptor with a Novel Tamoxifen Analogue Activates SF-1 and Promotes Endometrial Cell ProliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estrogens and selective estrogen receptor (ER) modulators such as tamoxifen are known to increase uterine cell proliferation. Mounting evidence suggests that estrogen signaling is mediated not only by ER and ERβ nuclear receptors, but also by GPR30 (GPER), a seven transmembrane (7TM) receptor. Here, we report that primary human endometriotic H-38 cells express high levels of GPR30 with no detectable ER or ERβ. Using a novel tamoxifen analogue, STX, which activates GPR30 but not ERs, significant stimulation of the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways was observe...
Source: Cancer Research - June 30, 2009 Category: Cancer & Oncology Authors: Lin, B. C., Suzawa, M., Blind, R. D., Tobias, S. C., Bulun, S. E., Scanlan, T. S., Ingraham, H. A. Tags: Experimental Therapeutics, Molecular Targets, and Chemical Biology Source Type: journals

Docosahexaenoic Acid Induces Adipose Differentiation-Related Protein through Activation of Retinoid X Receptor in Human Choriocarcinoma BeWo Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adipose differentiation-related protein (ADRP) is associated with intracellular lipid droplets that accumulate neutral lipids. Here we report that ADRP expression in a human choriocarcinoma cell line, BeWo, is regulated through activation of retinoid X receptor (RXR) and peroxisome proliferator-activated receptor-gamma (PPARgamma). Incubation with docosahexaenoic acid (DHA) or oleic acid (OA) induced accumulation of triacylglycerol (TG) and ADRP in BeWo cells. DHA-induced ADRP expression was suppressed by RXR-antagonists, PA452 and HX531. However, oleic acid-induced ADRP expression was not blocked by the RXR-antagonist...
Source: Biological and Pharmaceutical Bulletin - June 30, 2009 Category: Drugs & Pharmacology Authors: Suzuki K, Takahashi K, Nishimaki-Mogami T, Kagechika H, Yamamoto M, Itabe H Tags: Biol Pharm Bull Source Type: journals

Osteolytic bone destruction resulting from relapse of a testicular tumour 23 years after inguinal orchiectomy and adjuvant chemotherapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case emphasizes the need for a life-long follow-up of patients with primary metastatic testicular cancer. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 30, 2009 Category: Journals (General) Source Type: journals

Pure choriocarcinoma of ovary diagnosed by fine needle aspiration cytology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pure ovarian choriocarcinoma is extremely rare and can develop as a germ cell tumor or as a metastasis from uterine or tubal gestational choriocarcinoma or rarely from an ovarian pregnancy. The cytomorphologic findings have been reported previously in different sites. However, this is the first case of pure ovarian choriocarcinoma diagnosed on cytology to the best of our knowledge. The distinction between a gestational and nongestational choriocarcinoma is difficult. A 19-year-old female patient presented with an irregular per-vaginal bleeding and a mass in lower abdomen. Fine needle aspiration cytology smears of the m...
Source: Indian Journal of Pathology and Microbiology - June 30, 2009 Category: Pathology Authors: Naniwadekar MR, Desai SR, Kshirsagar NS, Angarkar NN, Dombale VD, Jagtap SV Tags: Indian J Pathol Microbiol Source Type: journals

Structure-dependent activation of peroxisome proliferator-activated receptor (PPAR) gamma by organotin compounds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organotin compounds such as tributyltin (TBT) and triphenyltin (TPT) are frequent environmental contaminants and are suspected of disrupting endocrine function in vertebrates and invertebrates. Previously, we reported that TBT and TPT function as powerful agonists for peroxisome proliferator-activated receptor (PPAR) gamma and stimulate adipocyte differentiation via the PPARgamma signaling pathway. Our current study investigates the structure-dependent binding of butyltin and phenyltin compounds to PPARgamma and their ability to activate the receptor. A Scatchard analysis with purified recombinant PPARgamma demonstrate...
Source: Chemico-Biological Interactions - June 28, 2009 Category: Molecular Biology Authors: Hiromori Y, Nishikawa J, Yoshida I, Nagase H, Nakanishi T Tags: Chem Biol Interact Source Type: journals

Non-Gestational Uterine Choriocarcinoma in a Postmenopausal Woman.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This case further illustrates that choriocarcinoma may be seen in older women after a long menopausal period. Accurate diagnosis and treatment are essential, because the tumor is very chemosensitive and curable even in advanced stages. PMID: 19556820 [PubMed - as supplied by publisher] (Source: Onkologie)
Source: Onkologie - June 27, 2009 Category: Cancer & Oncology Authors: Yildiz R, Benekli M, Akyurek N, Coskun U, Kaya AO, Ozturk B, Yaman E, Buyukberber S Tags: Onkologie Source Type: journals

Re-evaluation of the role of STOX1 transcription factor in placental development and preeclampsiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Preeclampsia is a common disease of pregnancy, characterized by high blood pressure and proteinuria appearing from the second trimester of gestation. Preeclampsia has been shown to have a strong genetic component. In 2005 a positional cloning project led to the discovery of the STOX1 transcription factor, and mutations of this gene were proposed as causal for preeclampsia in Dutch families. Despite the publication of three contradictory studies, we have shown by analyzing the functional effects of STOX1 that its overexpression in choriocarcinoma cells recapitulates several transcriptomic aspects of preeclampsia. ...
Source: Journal of Reproductive Immunology - June 26, 2009 Category: Allergy & Immunology Authors: Virginie Rigourd, Sonia Chelbi, Caroline Chauvet, Régis Rebourcet, Sandrine Barbaux, Bettina Bessières, Françoise Mondon, Thérèse-Marie Mignot, Jean-Louis Danan, Daniel Vaiman Source Type: journals

Primary choriocarcinoma of uterine cervix treated by uterine artery drug pouring and embolism: one case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present one rare case proved by cervical biopsy. The patient was an 36-year-old Chinese woman with irregular vaginal bleeding for 60 days. A cervical tumoral mass was seen in the pelvic examination and biopsy revealed active hyperplasia of trophoblastic cell. Because of massive vaginal haemorrhage, the patient accepted uterine artery drug pouring and embolism emergently. This management had gained a satisfactory effect. Thus, Uterine artery drug pouring and embolism is one new and effective weapon for PCC, which can preserve the patient’s productive ability. Content Type Journal ArticleDOI 10.1007/s10330-009-00...
Source: The Chinese-German Journal of Clinical Oncology - June 15, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Protein processing by the placental protease, cathepsin PEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cathepsin P is a member of a family of placentally expressed cathepsins (PECs). The closest human homolog of cathepsin P is cathepsin L, a broad specificity enzyme that has functions in many tissues in addition to placenta. The gene duplications that gave rise to the PECs provide a rare opportunity to define proteolytic functions in placenta, a transient organ unique to mammals. Peptidyl substrate and inhibitor libraries have shown that cathepsin P has evolved an unusually restricted preference for substrates containing hydrophobic amino acids. Proteomic techniques were used to probe for substrates of this enzyme. Recombin...
Source: Molecular Human Reproduction - June 14, 2009 Category: Molecular Biology Authors: Hassanein, M., Bojja, A. S., Glazewski, L., Lu, G., Mason, R.W. Tags: Articles Source Type: journals

[Transcription, Chromatin, and Epigenetics] Placenta-specific Methylation of the Vitamin D 24-Hydroxylase Gene: IMPLICATIONS FOR FEEDBACK AUTOREGULATION OF ACTIVE VITAMIN D LEVELS AT THE FETOMATERNAL INTERFACEEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study strongly suggests that epigenetic decoupling of vitamin D feedback catabolism plays an important role in maximizing active vitamin D bioavailability at the fetomaternal interface. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - May 22, 2009 Category: Chemistry Authors: Novakovic, B., Sibson, M., Ng, H. K., Manuelpillai, U., Rakyan, V., Down, T., Beck, S., Fournier, T., Evain-Brion, D., Dimitriadis, E., Craig, J. M., Morley, R., Saffery, R. Tags: Transcription, Chromatin, and Epigenetics Source Type: journals

Impact of the diameter of SonoVue microbubbles on binding characteristics of a new contrast agent targeted to choriocarcinoma cells in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The binding capacity of the targeted SonoVue microbubbles to JARs is related to the diameter of the microbubble, which is determined by the shaking method before preparation. Modulating the diameter of SonoVue microbubbles may increase the binding rate and stability of targeted microbubbles to JARs, thus to improve the image of JARs. Content Type Journal ArticleDOI 10.1007/s10330-009-0008-8Authors Lixue Zhou, Sun Yat-sen University Department of Gynecology and Obstetrics, The Second Affiliated Hospital Guangzhou 510120 ChinaRuike Pan, Sun Yat-sen University Department of Gynecology and Obst...
Source: The Chinese-German Journal of Clinical Oncology - May 15, 2009 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Progesterone reducesPR and SP4 binding to the MMP-2 promoter, thereby suppressing transcription. Progesterone also promotes SP4 degradation. These novel mechanisms of MMP-2 regulation by progesterone provide the biological rationale for the use of progesterone in clinical settings associated with increased MMP-2 expression. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - May 9, 2009 Category: Endocrinology Authors: Shlomit Goldman, David H Lovett and Eliezer Shalev Source Type: journals

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study raises questions regarding the validity of using the placental cell lines that are currently available as model systems for immunological interactions between fetal trophoblast and maternal leucocytes bearing receptors for HLA molecules. PMID: 19368562 [PubMed - indexed for MEDLINE] (Source: Immunology)
Source: Immunology - April 30, 2009 Category: Allergy & Immunology Authors: Apps R, Murphy SP, Fernando R, Gardner L, Ahad T, Moffett A Tags: Immunology Source Type: journals

Differential expression of SOX2 and SOX17 in testicular germ cell tumors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined SOX2 and SOX17 expression patterns in a total of 67 cases, including 41 pure GCTs (32 seminomas and 9 embryonal carcinomas) and 26 mixed GCTs (9 foci of seminoma, 21 of embryonal carcinoma, 17 of yolk sac tumor, 19 of teratoma, and 5 of choriocarcinoma). All seminoma components showed diffuse SOX17 nuclear expression and were negative for SOX2. All but one of the embryonal carcinomas showed diffuse SOX2 nuclear expression with the one showing a focal reaction, whereas all were negative for SOX17. SOX17 was variably expressed in all yolk sac tumor components, but SOX2 was negative. Teratomas showed varia...
Source: American Journal of Clinical Pathology - April 30, 2009 Category: Pathology Authors: Nonaka D Tags: Am J Clin Pathol Source Type: journals

Protein phosphatase 1A (PPM1A) is involved in human cytotrophoblast cell invasion and migrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to investigate the expression of PPM1A in normal and malignant human placenta and its role in trophoblast invasion, which shares many similarities with invasion of tumor cells. By Western blotting and immunocytochemistry, significantly higher expression of PPM1A in human placental villi at term was found as compared with that during the first trimester. Furthermore, the expression level of PPM1A protein in hydatidiform moles was lower compared with that during normal pregnancy. We further investigated the function of PPM1A in extravillous trophoblast cell line HTR8/SVneo. Transwell migr...
Source: Histochemistry and Cell Biology - April 30, 2009 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: journals

Primary Pulmonary Choriocarcinoma Presenting with a Hemothorax.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 663DOI: 10.1097/JTO.0b013e31819cce6cAuthors: Seol, Hyun-Joo MD *; Lee, Ju-Han MD +; Lee, Ki Yeol MD ++; Kim, Je-Hyeong MD [S]; Lee, Nak-Woo MD [//]; Park, Hyung-Joo MD [P] (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - April 25, 2009 Category: Cancer & Oncology Tags: Abstract HTML PDF (0.979 M) Source Type: journals

Aspiration biopsy cytomorphology of primary pulmonary germ cell tumor metastatic to the brainEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Extragonadal germ cell tumors are uncommon and such tumors originating from the lung parenchyma are extremely rare. This is a case of 68-year-old female who was admitted with complaints of right-sided weakness, inability to maintain her balance, right-sided headache, and bloody sputum. Her workup revealed two enhancing brain lesions and large lung mass involving the left lower lobe. Fine-needle aspiration (FNA) of the lung followed by craniotomy was performed and the patient was initially diagnosed with lung adenocarcinoma metastatic to the brain based on the cytomorphology of the lung FNA and histology of the brain mass. ...
Source: Diagnostic Cytopathology - April 16, 2009 Category: Pathology Authors: Haitham Arabi, Mahendra Shah, Husain Saleh Source Type: journals

Estrogens and Human Papilloma Virus Oncogenes Regulate Human Ether-a-go-go-1 Potassium Channel ExpressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ether-à-go-go-1 (Eag1) potassium channels are potential tools for detection and therapy of numerous cancers. Here, we show human Eag1 (hEag1) regulation by cancer-associated factors. We studied hEag1 gene expression and its regulation by estradiol, antiestrogens, and human papillomavirus (HPV) oncogenes (E6/E7). Primary cultures from normal placentas and cervical cancer tissues; tumor cell lines from cervix, choriocarcinoma, keratinocytes, and lung; and normal cell lines from vascular endothelium, keratinocytes, and lung were used. Reverse transcription-PCR (RT-PCR) experiments and Southern blot analysis showed Eag1...
Source: Cancer Research - April 15, 2009 Category: Cancer & Oncology Authors: Diaz, L., Ceja-Ochoa, I., Restrepo-Angulo, I., Larrea, F., Avila-Chavez, E., Garcia-Becerra, R., Borja-Cacho, E., Barrera, D., Ahumada, E., Gariglio, P., Alvarez-Rios, E., Ocadiz-Delgado, R., Garcia-Villa, E., Hernandez-Gallegos, E., Camacho-Arroyo, I., M Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The correct diagnosis of metastatic germ cell tumors is critical, because these tumors can be effectively treated and are even cured with modern therapy. Their histopathologic diagnosis can be challenging without immunohistochemical markers, which currently have limitations. SALL4 is a novel stem cell marker essential to maintain pluripotency and self-renewal of embryonic stem cells. In the current study, the authors investigated the utility of SALL4 as a potential diagnostic marker for metastatic germ cell tumors.Ninety metastatic germ cell tumors from testis, ovary, and extragonadal sites were stained with a monoclonal S...
Source: Cancer - April 13, 2009 Category: Cancer & Oncology Authors: Dengfeng Cao, Peter A. Humphrey, Robert W. Allan Source Type: journals

Laparoscopic gastric resection for bleeding metastatic choriocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s004640010052 Journal Surgical EndoscopyOnline ISSN 1432-2218Print ISSN 0930-2794 Journal Volume Volume 15 Journal Issue Volume 15, Number 1 / January, 2001 (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 8, 2009 Category: Surgery Tags: Surgical Endoscopy Source Type: journals

Undifferentiated carcinoma of the liver with extensive choriocarcinoma componentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Undifferentiated carcinoma of the liver is very rare. Undifferentiated carcinomas with osteoclast-like giant cells or neuroendocrine features have been reported. As far as we know, undifferentiated carcinoma of the liver with extensive choriocarcinoma component has not been reported. Here we present a case report of undifferentiated carcinoma of the liver with extensive choriocarcinoma component in an old man. US and multiphasic contrast-enhanced CT showed a heterogenous hypovascular mass in spite of the extensive choriocarcinoma component, probably due to necrosis and poorly differentiated portion of the tumor. ...
Source: European Journal of Radiology Extra - April 5, 2009 Category: Radiology Authors: Miyeon Yie, Kyung Mi Jang, Min Jeong Kim, Hyun Lee, Sung Hye Koh, Eui Yong Jeon, Hee Sung Hwang, Kwangseon Min, Hye-Rim Park, In-Gyu Kim Source Type: journals