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Health disparities in the forensic sexual assault examination related to skin colorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known about the role of skin color in the forensic sexual assault examination. The purpose of this study was to determine whether anogenital injury prevalence and frequency vary by skin color in women after consensual sexual intercourse. The sample consisted of 120 healthy (63 Black, 57 White) women who underwent a forensic sexual assault examination following consensual sexual intercourse. Experienced sexual assault forensic examiners using visual inspection, colposcopy technique with digital imaging, and toluidine blue application documented the number, type, and location of anogenital injuries. Although 55% of...
Source: Journal of Forensic Nursing - November 18, 2009 Category: Nursing Authors: Marilyn S. Sommers, Jamison D. Fargo, Rachel B. Baker, Bonnie S. Fisher, Carol Buschur, Therese M. Zink Tags: Original Articles Source Type: journals

A validity study of the national UK colposcopy objective structured clinical examination--is it a test fit for purpose?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examines the validity and reliability of the British Society for Colposcopy and Cytopathology (BSCCP) objective structured clinical examination (OSCE). The BSCCP OSCE results obtained over eight OSCE circuits were analysed using SPSS 15. Face validity and content validity were established from expert opinion and blueprinting. Statistically significant difference was not shown in construct validity through level of experience (P=0.867, P=0.822, P=0.59, P=0.74, P=0.12, P=0.01; these are the P values for each of the patient interaction stations) however, concurrent validity was established against the gynaecology m...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - November 13, 2009 Category: OBGYN Authors: Shehmar M, Cruikshank M, Finn C, Redman C, Fraser I, Peile E Tags: BJOG Source Type: journals

Epidemiological studies of women under age 30 infected with human papillomavirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women under 30 years old with cervical intraepithelial neoplasia (CIN) or cervical cancer, in order to provide a basis for cervical cancer prevention and treatment. We recruited 2052 female cases from the education system in Futian District, Shenzhen city, from April 2006 to April 2008, with age ranging from 22 to 60 years old. Secondgeneration hybrid capture test was done for detection of female genital tract HPV and cervical colposcopy for screening CIN or cervical cancer. The prevalence of HPV and ...
Source: Frontiers of Medicine in China - November 6, 2009 Category: Journals (General) Tags: Frontiers of Medicine in China Source Type: journals

Women [ge]30 years of age with low grade squamous intraepithelial lesion (LSIL) have low positivity rates when cotested for high-risk human papillomavirus: Should we reconsider HPV triage for LSIL in older women?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High-risk human papillomavirus (HR-HPV) testing for colposcopy triage of low grade squamous intraepithelial lesion (LSIL) is not recommended because of high positive rates in young women. It remains unclear whether HR-HPV testing may be useful for triage of older women. We compiled HR-HPV data for women aged [ge]30 years with LSIL for the period March 1, 2006 to February 28, 2008. Follow-up cervical biopsy information was collected for the period March 1, 2006 to August 15, 2008. We used the Hybrid Capture II test performed on residual material from liquid-based Pap tests. Of 735 women, 254 had HR-HPV testing, and of these...
Source: Diagnostic Cytopathology - November 5, 2009 Category: Pathology Authors: Michael J. Thrall, Debora A. Smith, Dina R. Mody Source Type: journals

[Keynote Comment] Risk estimation for the next generation of prevention programmes for cervical cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Currently, screening programmes for cervical cancer usually rely on cytology as the first-line screen. Women who are found to be cytologically abnormal are triaged by carcinogenic human papillomavirus (HPV) DNA testing or by repeat cytology, or are referred directly for a colposcopic examination. At colposcopy, biopsies are taken from any apparent lesions. Treatment is decided on the basis of the combined cytological, colposcopic, and histological diagnoses during the patient's history. These decision processes are formalised in complex consensus management algorithms that narrow down the clinical management options to a s...
Source: The Lancet Oncology - October 29, 2009 Category: Cancer & Oncology Authors: Hormuzd A Katki, Sholom Wacholder, Diane Solomon, Philip E Castle, Mark Schiffman Tags: Keynote Comment Source Type: journals

Two Studies Focus on Factors Related to ColposcopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Younger women in an underserved population had a particularly high likelihood of colposcopic biopsy after cervical cancer screening compared to a repeat Pap test, and multiple biopsies during colposcopy were not associated with a higher risk of new human papillomavirus infections, according to the results of two studies published in the November Obstetrics & Gynecology. (Source: Modern Medicine)
Source: Modern Medicine - October 26, 2009 Category: Journals (General) Source Type: info

Sexually transmitted papillomavirus infections: epidemiology pathogenesis, clinic, morphology, important differential diagnostic aspects, current diagnostic and treatment optionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The family of human papilloma viruses (HPV) comprises more than 100 genotypes. Approximately 30 of the genotypes are responsible for infections in the human anogenital area. A precisely defined algorithm with the goal of diagnosing and removing HPV for a prolonged or indefinite length of time, as well as to protect the patient from any malignant ransformation, does not currently exist. The identification of HPV strains by PCR or DNA hybridization in lesional tissue provides higher security for the patients. In high-risk patients additional colposcopy, rectoscopy, and rethroscopy/cystoscopy increase the probability of prope...
Source: Anais Brasileiros de Dermatologia - October 23, 2009 Category: Dermatology Source Type: journals

Feasibility of focused ultrasound therapy for recurrent cervicitis with high-risk human papillomavirus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Focused ultrasound therapy is feasible and effective in the treatment of patients with HR-HPV-positive cervicitis. It may provide a useful non-invasive treatment for recurrent cervicitis with HR-HPV infection. Copyright (c) 2009 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 19852044 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - October 21, 2009 Category: Radiology Authors: Li CZ, Wang ZB, Yang X, Tang Y, Wang D, Huang Y, Fan XF Tags: Ultrasound Obstet Gynecol Source Type: journals

Updated NCCN Guidelines for Cervical Cancer Screening Highlight Appropriate Use of New HPV DNA TestsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Comprehensive Cancer Network (NCCN) recently updated the NCCN Guidelines for Cervical Cancer Screening to provide further recommendations for a subset of women with conflicting results on cervical cytology/Pap tests and Human papillomavirus (HPV) High Risk DNA tests. The NCCN Guidelines include recommendations regarding screening techniques, screening intervals, and management of abnormal screening resulting from cervical cytology/Pap smear and colposcopy. October 14, 2009 FOR... (Source: National Comprehensive Cancer Network)
Source: National Comprehensive Cancer Network - October 16, 2009 Category: Cancer & Oncology Source Type: organizations

An audit of cervical cytology in HIV-positive womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This audit demonstrates a high rate of cytological abnormalities among HIV+ women compared with the screening population at large. Implementation of NHSCSP guidelines has been difficult and requires improved care pathways between HIV clinics, primary care and laboratories. (Source: Cytopathology)
Source: Cytopathology - October 14, 2009 Category: Pathology Authors: O. E. O. Hotonu, J. Hussey, M. S. T. Basta, V. Wadehra, P. Cross, M. L. Schmid Source Type: journals

DNA Ploidy Cytometry Testing for Cervical Cancer Screening in China (DNACIC Trial): a Prospective Randomized, Controlled Trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results highlight the benefit of the DNA cytometry testing strategy in mass cervical cancer screening with greater sensitivity and positive predicted value than the conventional cytologic testing in developing settings. (Clin Cancer Res 2009;15(20):6438-45). PMID: 19825960 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - October 12, 2009 Category: Cancer & Oncology Authors: Tong H, Shen R, Wang Z, Kan Y, Wang Y, Li F, Wang F, Yang J, Guo X, Tags: Clin Cancer Res Source Type: journals

Biopsy and LLETZ increase after effects after colposcopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Women who have cervical punch biopsies and large loop excision of the transformation zone during colposcopy for low-grade cytology experience a high rate of after-effects, conclude investigators. (Source: MedWire News - Ob/Gyn)
Source: MedWire News - Ob/Gyn - October 12, 2009 Category: OBGYN Source Type: news

Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite the two-tiered classification of dysplasia in The Bethesda System (TBS), rare cases fall into the category squamous intraepithelial lesion (SIL) of indeterminate grade. These Pap tests are often interpreted as "LSIL/ASC-H" or "LSIL" with a comment indicating the presence of cells with features approaching HSIL. Patients with LSIL/ASC-H have a significant risk of CIN 2 or worse (29-61.5%) on follow-up cervical biopsies, similar to the risk of CIN 2 or worse in patients with ASC-H Pap tests (24-68%). The purpose of this study was to compare patients with ASC-H and LSIL/ASC-H Pap tests. Women with LSIL/ASC-H had a sli...
Source: Diagnostic Cytopathology - October 6, 2009 Category: Pathology Authors: Megan J. Difurio, Thomas Mailhiot, Michael J. Sundborg, Karen K. Nauschuetz Source Type: journals

Human papillomavirus typing and viral gene expression analysis for the triage of women with abnormal results from papanicolaou test smears to colposcopy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The RQ of HPV E6 mRNA and HPV genotype could be useful in a cascade of diagnostic testing designed to refer women with findings of cervical abnormalities for colposcopy or treatment while reducing triage numbers. PMID: 19792047 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Authors: Antonishyn NA, Horsman GB, Kelln RA, Severini A Tags: Arch Pathol Lab Med Source Type: journals

An audit of cervical cytology smear results reported as "Dyskaryosis, difficult to grade; Colposcopy advised"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No abstract. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - September 29, 2009 Category: Pathology Authors: S. Conlon, M. Redmond, I. Nolan, M. Leader, E. W. Kay, A. Grace Source Type: journals

Sexual assault in postmenopausal women: epidemiology and patterns of genital injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The postmenopausal woman is not immune from sexual assault. The epidemiology of sexual trauma in this age group is uniquely different when compared to younger women, which may be useful in planning intervention and prevention strategies. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - September 24, 2009 Category: Emergency Medicine Authors: Jeffrey S. Jones, Linda Rossman, Renae Diegel, Phyllis Van Order, Barbara N. Wynn Tags: Original Contributions Source Type: journals

[Women aged 50-74 years follow-up after cervical cytological Ascus abnormalities in cancer screening: Adherence to the clinical practice guideline in Isere, France; 1991-2000.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The follow-up of Ascus cytological abnormalities is not according to guideline. The follow-up in the screening program will be intensified. PMID: 19782628 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)
Source: Gynecologie, Obstetrique & Fertilite - September 23, 2009 Category: OBGYN Authors: Billette-de-Villemeur A, Poncet F, Garnier A, Marron J, Le Marc'hadour F, Morens A, Rouault-Plantaz V, Ney M, Exbrayat C Tags: Gynecol Obstet Fertil Source Type: journals

Histologic and colposcopic correlation of cervical cytology showing “? glandular neoplasia”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cytology samples with “? glandular neoplasia” are associated with significant pathology. Colposcopy is important in the assessment of this group of patients. Endometrial assessment should be offered to all patients above the age of 50 years or postmenopausal presenting with such cytology. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1232-8Authors Mo’iad Alazzam, G18, Sheffield Gynaecology Cancer Centre Glossop Road Sheffield S10 2JF UKAileen Patterson, Addenbrookes Hospital Department of Histopathology Cambridge UKMahmood Shafi, Addenbrookes Ho...
Source: Archives of Gynecology and Obstetrics - September 23, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

A longitudinal 2-year follow-up of quality of life in women referred for colposcopy after an abnormal cervical smearEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Women experienced long-lasting negative effects on their mental health, but not on their physical health after referral for colposcopy. LLETZ had no measurable influence on QoL at any of the visits. This indicates that it is not the severity of the lesions or the treatment itself that affects women but the fact of having had an abnormal cervical smear identified. Depressive mood may be a major variable for the perception of low QoL. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - September 23, 2009 Category: OBGYN Authors: C. Hellsten, K. Sjöström, P.G. Lindqvist Tags: Gynaecology and Gynaecological Oncology Source Type: journals

Postmenopausal bleeding as first sign of an acute myelogenous leukaemia: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a woman with PMB as the first sign of an acute myelogenous leukaemia (AML). An 81-year-old patient presented with PMB. Manual and colposcopic examination raised suspicion of a cervical carcinoma, but histopathology and cervical Pap smear altered the diagnosis to granulocytic sarcoma (GS), an extramedullary manifestation of AML. The patient had a normal blood count 2 weeks prior to the examination, but at the time of presentation her leukocytes had risen to 116000/μl. The patient died 3 days later due to a pulmonary embolism, most probably as a result of leukostasis. In this case, GS o...
Source: Medical Oncology - September 17, 2009 Category: Cancer & Oncology Tags: Medical Oncology Source Type: journals

Detection of cervical intraepithelial neoplasia in vivo using confocal endomicroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Confocal endomicroscopy is a sensitive imaging tool for detection and assessment of CIN. The technique enables in vivo imaging of cervical histology and the potential for 'see-and-treat' workflows. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - September 13, 2009 Category: OBGYN Authors: J Tan, MA Quinn, JM Pyman, PM Delaney, WJ McLaren Source Type: journals

Gonococcal peritonitis diagnosed post laparotomy in a 38 year-old woman: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 38-year-old South African lady with a background history of cervical intra-epithelial neoplasia and recent colposcopy presented to the emergency department with severe abdominal pain. Initial investigations were non-diagnostic and despite empirical antibiotic therapy the patient developed peritonism. Post-laprotomy the diagnosis of severe pelvic inflammatory disease and peritonitis secondary to infection with Neisseria gonorrhoea was established. (Source: Cases Journal)
Source: Cases Journal - September 8, 2009 Category: Journals (General) Source Type: journals

HPV genotyping in anogenital abnormal samples of Ecuadorian women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We found 23 different genotypes. 84/104 cases were positive for HPV (67.7%); 32/124 cases were negative (25.8%); and, in 8/124 cases (6.5%) we were unable to ascertain the existence or lack of HPV. The most common viral genotype was 6 (8.8%) followed by the 66 (4.8%) and 16, 31, 44 types (2.4% each one). Types 11, 34, 35, 54, 59, 62 and 67 showed a frequency equivalent to 1.6% each one. The remaining types showed a 0.8% frequency. Most common high-risk genotypes were 16 and 31, low-risk 6 and 41 and, the third most common group HPV type detected in this cohort was HPV 66. HPV 6 showed the highest prevalence. H...
Source: Cancer Biomarkers : Section A of Disease Markers - September 5, 2009 Category: Cancer & Oncology Authors: González-Andrade F, Sánchez D Tags: Cancer Biomark Source Type: journals

Evaluation of a single-step diagnosis and treatment of premalignant cervical lesion by LEEPEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The single-step diagnosis and LEEP treatment of premalignant cervical lesions is appropriate in low-resource countries. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - September 4, 2009 Category: OBGYN Authors: Mohamed Emam, Aboubakr Elnashar, Hesham Shalan, Rafik Barakat Tags: Clinical articles Source Type: journals

Human Papillomavirus Testing for Cervical Cancer Screening: Results From a 6-Year Prospective Study in Rural ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates that a single oncogenic HPV-DNA test is more effective than cytology in predicting future CIN2+ status. (Source: American Journal of Epidemiology)
Source: American Journal of Epidemiology - September 2, 2009 Category: Epidemiology Authors: Shi, J.-F., Belinson, J. L., Zhao, F.-H., Pretorius, R. G., Li, J., Ma, J.-F., Chen, F., Xiang, W., Pan, Q.-J., Zhang, X., Zhang, W.-H., Qiao, Y.-L., Smith, J. S. Tags: RESEARCH-ARTICLE Source Type: journals

A pilot study evaluating the safety of vaginal administration of a multi-particulate pellet formulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: No major differences could be observed between the groups, whereby all changes in pH and microflora could be ascribed to withdrawal bleeding, indicating that gelatin capsules, starch pellets and lyophilized powder are acceptable carrier materials for the vaginal delivery of probiotic strains. PMID: 19733660 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutics and Biopharmaceutics)
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 2, 2009 Category: Drugs & Pharmacology Authors: Santiago GL, Poelvoorde N, De Corte S, Claeys G, Trog M, De Backer E, Saerens B, Vervaet C, De Boeck F, Van Bortel L, Remon JP, Temmerman M, Vaneechoutte M, Verhelst R Tags: Eur J Pharm Biopharm Source Type: journals

Follow-up findings for women with human papillomavirus-positive and atypical squamous cells of undetermined significance screening test results in a large women's hospital practice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The risk of CIN 2/3 in the study population was significantly lower than reported in widely cited trial data. Neither presence nor absence of an EC/TZS, nor the age of the patient, had a statistically significant impact on the likelihood of biopsy diagnoses of CIN 2/3 and CIN 1 for patients with HPV-positive ASC-US test results. PMID: 19722749 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2009 Category: Laboratory Medicine Authors: Armah H, Austin RM, Dabbs D, Zhao C Tags: Arch Pathol Lab Med Source Type: journals

Male partner involvement in reducing loss to follow-up after cervical cancer screening in UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Male partner involvement significantly reduced loss to follow-up among women referred for colposcopy. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - August 31, 2009 Category: OBGYN Authors: Twaha Mutyaba, Florence Mirembe, Sven Sandin, Elisabete Weiderpass Tags: Clinical articles Source Type: journals

[Reflection and Reaction] Further analysis of the ARTISTIC trial – Author's replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Collaborative analyses of relevant trials are needed to explain the much smaller number of additional cases of cervical intraepithelial neoplasia grade 3 and above (CIN3+) detected by HPV testing in the ARTISTIC trial than in other apparently similar studies. One important factor mentioned by Sasieni and colleagues was that many cytologically normal women with persistent HPV were not referred to colposcopy before round 2 (the first cytology 26–54 months after entry), mainly because they did not attend for retesting at 12 months. However, the effect is reduced in the combined round 1 and round 2 results, as CIN3+ in late ...
Source: The Lancet Oncology - August 26, 2009 Category: Cancer & Oncology Authors: Henry C Kitchener, Julian Peto Tags: Reflection and Reaction Source Type: journals

Process performance of cervical screening programmes in EuropeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Standardised tables of aggregated data were collected from 15 European national or regional cervical screening programmes and key performance indicators computed as reported in European Union (EU) Guidelines, 2nd edition.Cytological results varied widely between countries both for the total proportion of abnormal tests (from 1.2% in Germany (Mecklenburg-Vorpommern) to 11.7% in Ireland-Midwest Region) and for their distribution by grade. Referral rates for repeat cytology (ranging from 2.9% of screened women in the Netherlands to 16.6% in Slovenia) or for colposcopy (ranging from 0.8% in Finland to 4.4% in Romania...
Source: European Journal of Cancer - August 26, 2009 Category: Cancer & Oncology Authors: Guglielmo Ronco, Marjolein van Ballegooijen, Nikolaus Becker, Arkadiusz Chil, Muriel Fender, Pamela Giubilato, Juozas Kurtinaitis, Lesz Lancucki, Elsebeth Lynge, Antonio Morais, Marian O’Reilly, Pär Sparen, Ofelia Suteu, Matejka Rebolj, Piret Veerus, M Source Type: journals

High-risk human papillomavirus testing for monitoring patients treated for high-grade cervical intraepithelial neoplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HR-HPV testing in conjunction with Pap smear offers clear advantages over single cytology when monitoring women treated for high-grade CIN. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 23, 2009 Category: OBGYN Authors: Nan Hee Jeong, Nak Woo Lee, Hai Joong Kim, Tak Kim, Kyu Wan Lee Source Type: journals

Simultaneous squamous cell carcinoma in situ and adenocarcinoma in situ of the uterine cervix in a 36-year-old Japanese womanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The author reported a Japanese case of combined SIS and AIS, so far infrequently reported in Japanese woman. Content Type Journal ArticleCategory Gynecologic OncologyDOI 10.1007/s00404-009-1208-8Authors Tadashi Terada, Shizuoka City Shimizu Hospital Department of Pathology Miyakami, 1231 Shimizu-Ku Shizuoka 424-8636 Japan Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - August 19, 2009 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Human Papillomavirus Testing for Cervical Cancer Screening: Results From a 6-Year Prospective Study in Rural China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates that a single oncogenic HPV-DNA test is more effective than cytology in predicting future CIN2+ status. PMID: 19692327 [PubMed - as supplied by publisher] (Source: Am J Epidemiol)
Source: Am J Epidemiol - August 18, 2009 Category: Epidemiology Authors: Shi JF, Belinson JL, Zhao FH, Pretorius RG, Li J, Ma JF, Chen F, Xiang W, Pan QJ, Zhang X, Zhang WH, Qiao YL, Smith JS Tags: Am J Epidemiol Source Type: journals

Value of p16INK4a as a marker of progression/regression in cervical intraepithelial neoplasia grade 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: p16INK4a negative cervical intraepithelial neoplasia grade 1 lesions rarely progress and may benefit from a less intensive follow-up. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - August 17, 2009 Category: OBGYN Authors: Marta del Pino, Sònia Garcia, Victòria Fusté, Immaculada Alonso, Pere Fusté, Aureli Torné, Jaume Ordi Tags: Oncology Source Type: journals

Comparison of methods trial for high-risk HPVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In efforts to improve service, we compared the performance of four methods of HPV detection: Invader® HPV (Hologic), Hybrid Capture 2® (Qiagen), Inform® HPV detection (Ventana), and standard PCR.Using blinded/de-identified cervical samples in Preservcyt® (Hologic), we compared Ventana's Inform® HPV Test, against Hologic's HPV Invader® and PCR. In a separate evaluation, we compared Inform® versus Invader versus hc2®. Ventana employs in situ hybridization; Hologic's technology uses three specifically designed oligonucleotides and a fluorescent signal for detection. Qiagen's hc2® method incorporates enzyme-linked ant...
Source: Diagnostic Cytopathology - August 16, 2009 Category: Pathology Authors: Daniel F. I. Kurtycz, Michele Smith, Rong He, Kayo Miyazaki, John Shalkham Source Type: journals

An Alternative Treatment for Cervical Intraepithelial Neoplasia II, IIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report describes a case of a woman with progressive and recurrent cervical dysplasia 4 years after cervical conization for severe dysplasia. Patient and methods. A 20-year-old female was referred for colposcopy and biopsy following results of moderate to severe atypia of cervical cells on her Papanicolaou (Pap) test. Her colposcopy was satisfactory and her biopsy revealed cervical intraepithelial neoplasia (CIN) II, III. She refused the conventional recommendation of loop electrosurgical excision procedure (LEEP) and, as an alternative, elected to receive escharotic treatment at a frequency of 2 treatments per week fo...
Source: Integrative Cancer Therapies - August 12, 2009 Category: Cancer & Oncology Authors: Swanick, S., Windstar-Hamlin, K., Zwickey, H. Tags: Article Source Type: journals

Analysis of outcome in women with borderline glandular change on cervical cytologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Colposcopic examination and biopsy of colposcopically identified abnormalities is reliable, with negative colposcopy having a high negative predictive value. We also recommend thorough colposcopic examination before any invasive investigation as over treatment may impact on the future reproductive outcome . (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - August 11, 2009 Category: OBGYN Authors: Bismeen A. Jadoon, Sean Kehoe, Kathleen Romain, Colin Clelland, Sudha S. Sundar Tags: Gynaecology and Gynaecological Oncology Source Type: journals

Aceto-white temporal pattern classification using k-NN to identify precancerous cervical lesion in colposcopic imagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: After Pap smear test, colposcopy is the most used technique to diagnose cervical cancer due to its higher sensitivity and specificity. One of the most promising approaches to improve the colposcopic test is the use of the aceto-white temporal patterns intrinsic to the color changes in digital images. However, there is not a complete understanding of how to use them to segment colposcopic images. In this work, we used the classification algorithm k-NN over the entire length of the aceto-white temporal pattern to automatically discriminate between normal and abnormal cervical tissue, reaching a sensitivity of 71% a...
Source: Computers in Biology and Medicine - August 6, 2009 Category: Bioinformatics Authors: Héctor-Gabriel H.G. Acosta-Mesa, Nicandro Cruz-Ramírez, Rodolfo Hernández-Jiménez Source Type: journals

Frequency and types of human papillomavirus among pregnant and non-pregnant women with human immunodeficiency virus infection in Recife determined by genotyping.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study identified high-risk HPV types in all three groups examined (HIV-positive pregnant women, HIV-negative pregnant women and HIV-positive not pregnant), characterising its distribution in this setting. PMID: 19820838 [PubMed - in process] (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - July 31, 2009 Category: Infectious Diseases Authors: Brandão Vda C, Lacerda HR, Lucena-Silva N, Ximenes RA Tags: Mem Inst Oswaldo Cruz Source Type: journals

A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-up for one year. Colposcopy, cervical biopsy for histology and brushings for HPV typing was performed at recruitment, 6 months (no biopsy) and upon completion of the study at one year. HPV16-specific T-cell responses were analysed by interferon-[gamma] ELISPOT at entry, 6 and 12 months. Infection with multiple...
Source: International Journal of Cancer - July 29, 2009 Category: Cancer & Oncology Authors: Yin Ling Woo, Muriel van den Hende, Jane C Sterling, Nicholas Coleman, Robin A.F. Crawford, Kitty M.C. Kwappenberg, Margaret A Stanley, Sjoerd H. van der Burg Source Type: journals

Aggressive Approach to Cervix Abnormalities QuestionedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The benefits of referring women for immediate colposcopy or aggressive treatment instead of cytological surveillance following detection of low-grade cervical abnormalities may not outweigh the risks of overtreatment, according to three related studies from the Trial Of Management of Borderline and Other Low-grade Abnormal smears (TOMBOLA) published online on July 28 in BMJ. (Source: Modern Medicine)
Source: Modern Medicine - July 28, 2009 Category: Journals (General) Source Type: info

Local BCG injection administered to patients with flat condyloma of the cervixEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HPV infection is the most commonly diagnosed sexually transmitted viral infection . The cervical lesion is typically seen at colposcopy and is known as flat condyloma. Different treatment modalities for flat condyloma range from follow-up to local excision or destruction using the large loop electrosurgical excision procedure (LEEP), laser vaporization, or cryosurgery. Half of all patients treated with LEEP return to the clinic at some point for either recurrence or appearance of a new lesion . In the absence of specific antiviral treatment, the ability to enhance local immunity to overcome the viral infection is worth inv...
Source: International Journal of Gynaecology and Obstetrics - July 24, 2009 Category: OBGYN Authors: Salah T. Fayed, Mohammad Amer, Esam Ammar, Magda Abdel Salam Tags: Brief communications Source Type: journals

Update on ASCCP consensus guidelines for abnormal cervical screening tests and cervical histology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New data have emerged since publication of the American Society for Colposcopy and Cervical Pathology's 2001 consensus guidelines for management of abnormal cervical cytology and histology. The 2006 guidelines include recommendations for special populations (i.e., adolescents and pregnant women). Human papillomavirus testing is now included for management of atypical glandular cytology, for follow-up after treatment for cervical intraepithelial neoplasia, and in combination with cytologic screening in women 30 years and older. The preferred management of atypical squamous cells of undetermined significance in adult wom...
Source: American Family Physician - July 14, 2009 Category: Primary Care Authors: Apgar BS, Kittendorf AL, Bettcher CM, Wong J, Kaufman AJ Tags: Am Fam Physician Source Type: journals

After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cervical punch biopsies and, especially, LLETZ carry a substantial risk of after-effects. After-effects are also reported by women managed solely by colposcopic examination. Ensuring that women are fully informed about after-effects may help to alleviate anxiety and provide reassurance, thereby minimising the harms of screening. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - July 7, 2009 Category: OBGYN Source Type: journals

After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cervical punch biopsies and, especially, LLETZ carry a substantial risk of after-effects. After-effects are also reported by women managed solely by colposcopic examination. Ensuring that women are fully informed about after-effects may help to alleviate anxiety and provide reassurance, thereby minimising the harms of screening. PMID: 19583712 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - July 6, 2009 Category: OBGYN Tags: BJOG Source Type: journals

Incidence and outcome of acquisition of human papillomavirus infection in women with normal cytology - A population-based cohort study from TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Little is known about acquisition of human papillomavirus (HPV) and its outcome among older women with negative HPV testing and normal cytology. A longitudinal 3-yr follow-up of nested-cohort subjects (n = 8825) from a population-based cervical cancer screening study whose Pap and HPV tests were negative at baseline were conducted. Every active HPV-negative (n = 413) participant had 12-mo follow-ups of Pap smear and HPV testing. Colposcopy was performed if either HPV-positive or cytology was abnormal. The cytology and histology information of the remaining subjects (passive HPV-negative, n = 8412) was obtained from nationa...
Source: International Journal of Cancer - July 6, 2009 Category: Cancer & Oncology Authors: Angel Chao, Chee-Jen Chang, Chyong-Huey Lai, Fang-Yu Chao, Yi-Hsien Hsu, Hung-Hsueh Chou, Huei-Jean Huang, Shih-Ming Jung, Cheng-Tao Lin, Hui-Hsin Cheng, Chu-Chun Huang, Jung-Erh Yang, Ting-Chang Chang Source Type: journals

Use of an expanded gold standard to estimate the accuracy of colposcopy and visual inspection with acetic acidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We estimate the accuracy of colposcopy and visual inspection with acetic acid (VIA) while minimizing the effects of misclassification bias, and maximizing ascertainment of disease. VIA was performed by experienced physicians on a population-based sample of women aged 30 to 49 years in rural Shanxi province, China. Each woman received VIA, liquid-based cytology (LBC) and hybrid capture 2 (hc2, QIAGEN, Gaithersburg, MD; formerly Digene Corporation). Any woman who tested positive on any test had colposcopy, endocervical curettage (ECC) with directed biopsies as necessary and 4-quadrant random biopsies from normal-appearing ar...
Source: International Journal of Cancer - July 6, 2009 Category: Cancer & Oncology Authors: A.J. Cagle, S.Y. Hu, J.W. Sellors, Y.P. Bao, J.M. Lim, S.M. Li, K. Lewis, Y. Song, J.F. Ma, Q.J. Pan, W.H. Zhang, F.H. Zhao, Y.L. Qiao Source Type: journals

Cancer Screening: Does It Really Save Lives?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Anne is a good patient. She sees her doctor for regular checkups, has yearly mammograms, Pap tests, and colon cancer screenings, and she even paid for a full-body CT scan out of her own pocket. She figures she's doing everything she can to make sure she doesn't get cancer.Truth is, Anne is doing nothing to prevent cancer. Although cancer screening is billed as a preventive service that saves lives, the best it can do is detect disease in its early stages, when it is supposedly easier to treat. Nevertheless, every year millions of Americans dutifully line up for their screenings, completely unaware that they m...
Source: NaturalNews.com - July 6, 2009 Category: Consumer Health Advice Source Type: news

Use of Misoprostol for Management of Unsatisfactory Colposcopy in the Adolescent: A Case Report and Review of the LiteratureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In the presence of persistent atypia in an adolescent female with an unsatisfactory colposcopy, consider using a prostaglandin analogue for adequate evaluation of the endocervix, prior to proceeding with an ablative or excisional therapy. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - July 5, 2009 Category: OBGYN Authors: L. Ayensu-Coker, J. Sanchez, R. Zurawin, J.E. Dietrich Tags: Case Reports Source Type: journals

Predictors of Genital Injury After Nonconsensual IntercourseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Understanding differences in genital injuries after nonconsensual and consensual intercourse is an important element of prosecuting sexual assault cases. In order to determine if the injury patterns and total surface area of genital injuries can differentiate between the types of intercourse (consensual or non-consensual), eighty women were examined after non-consensual (retrospective chart review, n = 40) and consensual (recruited, n = 40) intercourse within 48 hours using colposcopy, toluidine blue dye, and digital photography to document genital injuries. Differences between types of injuries found in the nonconsensual ...
Source: Advanced Emergency Nursing Journal - July 1, 2009 Category: Emergency Medicine Tags: Article Source Type: journals