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This page shows you the latest news and research items in this category.

Patterned genital injury in cases of rape – A case–control study
In conclusion, this study has confirmed the existence of different patterns of genital lesions. Background data for detection of genital lesions using the three most commonly used techniques is provided. These results will aid in the interpretation of findings seen when examining sexual assault victims. (Source: Journal of Forensic and Legal Medicine)
Source: Journal of Forensic and Legal Medicine - June 14, 2013 Category: Forensic Medicine Authors: Birgitte Schmidt Astrup, Pernille Ravn, Jørgen Lange Thomsen, Jens Lauritsen Tags: Short Reports Source Type: research

Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions
This study demonstrates that the HPV MLPA assay can reliably detect HPV 16/18, viral load, and viral integration in cytological samples. Also, high‐risk classification correlated well with the presence of high‐grade dysplasia. However, for the implementation of the MLPA assay into clinical practice, additional HR‐HPV types need to be included to increase the sensitivity of the assay, and thereby increase its negative predictive value. J. Med. Virol. 85:1386–1393, 2013. © 2013 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - June 13, 2013 Category: Virology Authors: Rogier J.N.T.M. Litjens, Wendy Theelen, Yvonne van de Pas, Jessica Ossel, Martin Reijans, Guus Simons, Ernst‐Jan M. Speel, Brigitte F.M. Slangen, Frans C.S. Ramaekers, Roy F.P.M. Kruitwagen, Anton H.N. Hopman Tags: Research Article Source Type: research

Clinical significance of atypical squamous cells cannot exclude high grade squamous intraepithelial lesion with histologic correlation—: A 9‐Year experience
We report on our experience at the University of Wisconsin Hospital and Clinics. From January 1, 2003 through December 31, 2011 (9‐y), the cytopathology laboratory processed 109,424 Pap Tests, of which 281 (0.26%) were diagnosed as ASC‐H. Tissue follow‐up was available in 181 (64%) of these cases, of which 45 (25%) were negative/cervicitis, 41 (23%) were CIN 1, 36 (20%) were CIN 2 and 59 (32%) were CIN 3. Stratification by age groups showed a higher percentage of high grade (CIN 2+) lesions (65%) in the premenopausal age group as compared with high grade lesion (35%) in the postmenopausal age group, whereas negative/...
Source: Diagnostic Cytopathology - June 8, 2013 Category: Pathology Authors: Suzanne M. Selvaggi Tags: Original Article Source Type: research

What is a Colposcopy?
A colposcopy is a follow-up procedure for abnormal Pap smears. Learn why a oolposcopy is performed, what to expect, and more about colposcopy results. (Source: About.com Cervical Cancer)
Source: About.com Cervical Cancer - June 5, 2013 Category: Cancer & Oncology Authors: cervicalcancer.guide at about.com Tags: health Source Type: news

Can a colposcopy exam be done if a woman is on...
Can you get a colposcopy exam during your period? Learn more in the FAQ from a reader who asks if she should get a coposcopy exam during her period. (Source: About.com Cervical Cancer)
Source: About.com Cervical Cancer - June 5, 2013 Category: Cancer & Oncology Authors: cervicalcancer.guide at about.com Tags: health Source Type: news

[Appraisal of the optical diagnostic technique for cervical intra-epithelial neoplasia by polarimetric imaging "Polcolpo". Comparison with colposcopic and histological diagnoses by biopsy.]
CONCLUSION: We could not demonstrate any improvement of the diagnostic performances with polarimetric colposcopy alone. However, for both healthy and pathological cervices, we observed interesting polarimetric responses involving other characteristics than those we initially assumed, and which will be taken into account in a future study. PMID: 23747216 [PubMed - as supplied by publisher] (Source: Reproductive Biology)
Source: Reproductive Biology - June 5, 2013 Category: Reproduction Medicine Authors: Nazac A, Pierangelo A, Vercambre M, Huynh B, Cohen H, Coudert M, Mallet A, De Martino A Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: research

Laparoscopic upper vaginectomy for post-hysterectomy high risk vaginal intraepithelial neoplasia and superficially invasive vaginal carcinoma
Conclusions: LUV after hysterectomy is a feasible procedure and attentively applicable to high risk VAIN or superficially invasive vaginal carcinoma. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - June 3, 2013 Category: Cancer & Oncology Authors: Youn Jin ChoiSoo Young HurJong Sup ParkKeun Ho Lee Source Type: research

Colposcopy: A Global Perspective: Introduction of the New IFCPC Colposcopy Terminology
This article describes the current nomenclature of colposcopic findings in the lower genital tract as defined by the International Federation for Cervical Pathology and Colposcopy (IFCPC) and agreed at their Triennial General Meeting in July 2012 in Rio de Janeiro. It builds on previous nomenclature published by the IFCPC over the last two decades and introduces for the first time the concept of transformation zone excision types. Vulval and vaginal colposcopic terminology is described. (Source: Obstetrics and Gynecology Clinics)
Source: Obstetrics and Gynecology Clinics - June 1, 2013 Category: OBGYN Authors: Silvio Tatti, Jacob Bornstein, Walter Prendiville Source Type: research

Treatment Options for High-Grade Squamous Intraepithelial Lesions
The introduction of testing for high-risk HPV types and P16 immunostaining of CIN2 histologic specimens allows for determination of the risk of progression versus regression for a woman with a particular cytologic or histologic specimen. Observation with serial cytological or colposcopic examinations is now appropriate for women with low-grade histologic lesions as well as pregnant and young women with certain high-grade histologic lesions. Current recommendations for management of high-grade lesions, the efficacy of treatment options (cryotherapy and LEEP), and the immediate (bleeding, infection) and longer term complicat...
Source: Obstetrics and Gynecology Clinics - June 1, 2013 Category: OBGYN Authors: Stephanie Long, Lawrence Leeman Source Type: research

Accuracy of colposcopy-directed punch biopsies.
PMID: 23659332 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 25, 2013 Category: OBGYN Authors: Moss E, Redman C, Arbyn M Tags: BJOG Source Type: research

Accuracy of colposcopy-directed punch biopsies.
PMID: 23659331 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 25, 2013 Category: OBGYN Authors: Siegler E, Mackuli L Tags: BJOG Source Type: research

Prospective evaluation of E6/E7 mRNA detection by the NucliSENS Easy Q HPV assay in a stepwise protocol
The objective of the study was to evaluate prospectively the added value of E6/E7 mRNA detection in a stepwise protocol. A total of 1,422 samples were collected over a period of 17 months. The samples were referred for human papillomavirus (HPV) genotyping if they showed cytological evidence of atypical squamous cells of undetermined significance, low‐ or high‐grade squamous intraepithelial lesion. If one or more of HPV types 16, 18, 31, 33, or 45 were present, mRNA was analyzed by the NucliSENS EasyQ HPV assay. The genotypical distribution of high‐risk HPV was very heterogeneous; HPV 16, 18, 31, 33, and 45 represent...
Source: Journal of Medical Virology - May 22, 2013 Category: Virology Authors: Elizaveta Padalko, Lieve Van Renterghem, Mieke Bamelis, Anja De Mey, Yolande Sturtewagen, Hilde Vastenavond, Steven Weyers, Marleen Praet Tags: Research Article Source Type: research

Patients with penile cancer and the risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis
ConclusionFemale partners of patients with penile cancer did not show more premalignant cervical lesions than in the general population. (Source: BJU International)
Source: BJU International - May 21, 2013 Category: Urology & Nephrology Authors: Bruijn RE, Heideman DAM, Kenter GG, Beurden M, Tinteren H, Horenblas S Tags: Original Article Source Type: research

New Cervical Cancer Screening Guidelines, Again
Guidelines for cervical cancer screening have continued to evolve as we have accumulated new information about the pathogenesis of cervical cancer and the role of the human papilloma virus. Most recently, the American Cancer Society, the American Society for Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology issued revised joint recommendations for the prevention and early detection of cervical cancer. In addition, the US Preventative Services Task Force revised its guidelines, and the American College of Obstetricians and Gynecologists updated its practice bulletin. (Source: Obstetrics and Gynecology Clinics)
Source: Obstetrics and Gynecology Clinics - May 13, 2013 Category: OBGYN Authors: Nicole Karjane, David Chelmow Source Type: research

Accuracy of colposcopy‐directed punch biopsies
(Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - May 10, 2013 Category: OBGYN Authors: E Siegler, L Mackuli Tags: BJOG Exchange Source Type: research

[Prevalence of genotype-specific HPV infection among women in France: Implications for screening and vaccination.]
CONCLUSION: These data indicate that almost all young women could benefit from HPV prophylactic vaccination, but confirm the need for continued cervical screening and highlight the need for future vaccines to target a wider range of HPV types. PMID: 23647817 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique et Fertilite)
Source: Gynecologie, Obstetrique et Fertilite - May 1, 2013 Category: OBGYN Authors: Monsonego J, Zerat L, Syrjänen K, Zerat JC, Smith JS, Halfon P Tags: Gynecol Obstet Fertil Source Type: research

Pooled analysis of the performance of liquid‐based cytology in population‐based cervical cancer screening studies in China
CONCLUSIONSThe results of the current study indicate that the performance of LBC can effectively predict the risk of existing CIN2+ and may be a good screening tool for cervical cancer prevention in a developing country. Cancer (Cancer Cytopathol) 2013;. © 2013 American Cancer Society. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - April 23, 2013 Category: Pathology Authors: Qin‐Jing Pan, Shang‐ying Hu, Xun Zhang, Pu‐wa Ci, Wen‐hua Zhang, Hui‐qin Guo, Jian Cao, Fang‐hui Zhao, Alice Lytwyn,, You‐lin Qiao Tags: Original Article Source Type: research

A pilot study of the feasibility of a vaginal washing cessation intervention among Kenyan female sex workers
Conclusions A theory-based intervention appeared to have a positive effect in reducing vaginal washing over 1 month. Larger studies with longer follow-up are important to further characterise the effects of vaginal washing cessation on biological markers. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 12, 2013 Category: Sexual Medicine Authors: Masese, L., McClelland, R. S., Gitau, R., Wanje, G., Shafi, J., Kashonga, F., Ndinya-Achola, J. O., Lester, R., Richardson, B. A., Kurth, A. Tags: Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Inflammation, HIV / AIDS, HIV infections, Sex workers, Vulvovaginal disorders, Surgical diagnostic tests Behaviour Source Type: research

Human papillomavirus (HPV) E6/E7 mRNA as a triage test after detection of HPV 16 and HPV 18 DNA
In conclusion, NucliSENS‐EasyQ® HPV E6/E7‐mRNA‐assay (Biomerieux) can serve as a triage test in case of HPV 16 and/or 18 DNA detection. J. Med. Virol. 85: 1063–1068, 2013. © 2013 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - April 12, 2013 Category: Virology Authors: Sonia Perez Castro, Amparo Iñarrea Fernández, María José Lamas González, María Teresa Sarán Diez, Ana Cid Lama, María Jesús Alvarez Martín, Mónica Pato Mosquera, Isabel López‐Miragaya, Nuria Estévez, Julio Torres Piñón, María Oña Navarr Tags: Research Article Source Type: research

Human papillomavirus reactivation following treatment of genital graft‐versus‐host disease
Abstract Vaginal chronic graft‐versus‐host disease (cGVHD) is a common complication of stem cell transplantation. Human papillomavirus (HPV) disease can reactivate after transplantation, presumably because of immune factors affecting systemic immunity, such as waning antibody titers, impaired T‐ and B‐lymphocyte responses, and the use of immunosuppressive therapies. However, a relationship between the use of local immunosuppressive agents and HPV reactivation and spread has not been previously described, to our knowledge. A 30‐year‐old woman, 2 years post transplant receiving systemic cyclosporine for cGVHD, w...
Source: Transplant Infectious Disease - April 1, 2013 Category: Transplant Surgery Authors: T. Sri, M.A. Merideth, T. Klepac Pulanic, R. Childs, P. Stratton Tags: Case report Source Type: research

HPV vaginal self-sampling among women non-adherent to Papanicolaou screening in Chile.
CONCLUSION: HPV vaginal self-sampling can be easily implemented in Chile and could improve coverage, successfully reaching women who drop out of the screening program. PMID: 23546407 [PubMed - in process] (Source: Salud Publica de Mexico)
Source: Salud Publica de Mexico - April 1, 2013 Category: Epidemiology Authors: Léniz J, Barriga MI, Lagos M, Ibáñez C, Puschel K, Ferreccio C Tags: Salud Publica Mex Source Type: research

Preface
In the 5 years since Obstetrics and Gynecology Clinics of North America last published an issue devoted to colposcopy and the prevention of cervical cancer, there have been significant developments in the field. While our understanding of the natural history of squamous lesions caused by infections with the human papillomavirus (HPV) has undergone incremental changes, the regimens for prevention of HPV-related cancers have changed more dramatically. In this issue we highlight some of those changes. (Source: Obstetrics and Gynecology Clinics)
Source: Obstetrics and Gynecology Clinics - April 1, 2013 Category: OBGYN Authors: Alan G. Waxman, Maria Lina Diaz Source Type: research

Effect of Thin Prep® imaging system on laboratory rate and relative sensitivity of atypical squamous cells, high-grade squamous intraepithelial lesion not excluded and high-grade squamous intraepithelial lesion interpretations
Conclusion: The similar rate of detection using TIS with an equal percentage of histologic correlation for ASC-H and HGSIL lesions on follow-up histology suggests patients screened by the TIS method are being sent for appropriate follow-up surveillance and treatment. A high-grade or possible high-grade lesion is as likely to be detected by TIS as by a manual screen. The similarities in relative sensitivity and specificity in a direct comparison between manual and TIS screening methodologies indicate that TIS compared to manual screening does not affect detection in patients with high-grade cervical lesions. (Source: CytoJournal)
Source: CytoJournal - March 30, 2013 Category: Pathology Authors: Brooke R KoltzDonna K RussellNaiji LuThomas A BonfiglioSharlin Varghese Source Type: research

The Lower Anogenital Squamous Terminology Project and Its Implications for Clinical Care
Based on a growing need for unified terminology to describe the pathologic and clinical spectrum of lesions, the American Society for Colposcopy and Cervical Pathology and the College of American Pathologists Pathology and Laboratory Quality Center convened the Lower Anogenital Squamous Terminology (LAST) Project to reassess and harmonize the terminology used to describe human papillomavirus-associated squamous lesions of the lower anogenital tract as manifested in a variety of end organs. The distinction between cancer precursors and those without malignant potential leads to consistency in the interpretation of managemen...
Source: Obstetrics and Gynecology Clinics - March 29, 2013 Category: OBGYN Authors: Tomas Nuño, Francisco García Source Type: research

Clinical evaluation of high-risk HPV detection on self-samples using the indicating FTA-elute solid-carrier cartridge
Conclusions: These results show that the clinical performance of hrHPV detection is determined by both the sample collection system and the test method. FTA-based self-collection with SPF10 testing might be valuable when a liquid-based medium cannot be used, but requires further investigation in screening populations. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - March 20, 2013 Category: Virology Authors: D.T. Geraets, R. van Baars, I. Alonso, J. Ordi, A. Torné, W.J.G. Melchers, C.J.L.M. Meijer, W.G.V. Quint Tags: Full length articles Source Type: research

Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: a case–control study
ConclusionsWomen with a history of cervical treatment for CIN are at increased risk of subfertility, measured as a time to pregnancy of more than 12 months. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - March 14, 2013 Category: OBGYN Authors: CN Spracklen, KK Harland, BJ Stegmann, AF Saftlas Tags: Original Article Source Type: research

Cervical surgery for cervical intraepithelial neoplasia and prolonged time to conception of a live birth: a case-control study.
CONCLUSIONS: Women with a history of cervical treatment for CIN are at increased risk of subfertility, measured as a time to pregnancy of more than 12 months. PMID: 23489374 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - March 14, 2013 Category: OBGYN Authors: Spracklen C, Harland K, Stegmann B, Saftlas A Tags: BJOG Source Type: research

HPV16 L1 and L2 DNA methylation predicts high‐grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology
DNA methylation changes in human papillomavirus type 16 (HPV16) DNA are common and might be important for identifying women at increased risk of cervical cancer. Using recently published data from Costa Rica we developed a classification score to differentiate women with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) from those with no evident high‐grade lesions. Here, we aim to investigate the performance of the score using data from the UK. Exfoliated cervical cells at baseline and 6‐months follow‐up were analyzed in 84 women selected from a randomized clinical trial of women undergoing surveillance for l...
Source: International Journal of Cancer - March 7, 2013 Category: Cancer & Oncology Authors: Attila T Lorincz, Adam R Brentnall, Nataša Vasiljević, Dorota Scibior‐Bentkowska, Alejandra Castanon, Alison Fiander, Ned Powell, Amanda Tristram, Jack Cuzick, Peter Sasieni Tags: Early Detection and Diagnosis Source Type: research

Abdominal Radical Hysterectomy and Cervical Cancer – Amy’s Story
Hi, I am 43 and live in South Wales, I have 2 children 16 and 22, a hubby and my 2 dogs My story started late in November 2012, when I decided to make an appointment at our local surgery to have my Mirena Coil changed, as I was there and my smear was due within the nest few months, decided to get it done at the same time (hating the speculum only doing it once seemed like a good idea). This is where my head spinning journey started. I had the procedure done on the 19th November, within a week I had a call from the hospital saying I had to go to the well woman clinic at the Royal Gwent Hospital for a colposcopy on the 29th...
Source: The Hysterectomy Association - March 1, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Cancer Your Stories cancer rage cervical cancer CIN3 Source Type: news

Association of Chlamydia trachomatis infection with human papillomavirus (HPV) & cervical intraepithelial neoplasia - A pilot study.
The objective of this pilot study was to determine the association of CT infection with HPV, other risk factors for cervical cancer, and CIN in symptomatic women. Methods: A total of 600 consecutively selected women aged 30-74 yr with persistent vaginal discharge, intermenstrual/postcoital bleeding or unhealthy cervix underwent conventional Pap smear, Hybrid Capture 2® (HC2) testing for HPV and CT DNA and colposcopy, with directed biopsy of all lesions. Results: HPV DNA was positive in 108 (18.0%) women, CT DNA in 29 (4.8%) women. HPV/CT co-infection was observed in only four (0.7%) women. Of the 127 (21.2%) women with Pa...
Source: The Indian Journal of Medical Research - March 1, 2013 Category: Biomedical Science Authors: Bhatla N, Puri K, Joseph E, Kriplani A, Iyer VK, Sreenivas V Tags: Indian J Med Res Source Type: research

Cigarette smoking and the frequency of colposcopy visits, treatments and re-referral.
This study also identified that 71% of Miori women attending the clinic were smokers compared to 44% of non-Maori women. It was also found that MSori women were less likely to attend the colposcopy clinic than were non-Maori. This study highlights to health professionals and to the women who undergo colposcopy, that treatment is more likely to be successful for patients who cease smoking. The results have also supported the importance and relevance of smoke-free education to women. This allows the link to cervical abnormalities and smoking to be explained and smoking cessation assistance offered. This information also high...
Source: Nursing Praxis in New Zealand - March 1, 2013 Category: Nursing Authors: Lamb J, Dawson SI, Gagan MJ, Peddie D Tags: Nurs Prax N Z Source Type: research

Human Papillomavirus Types Distribution in Eastern Sicilian Females with cervical lesions. A Correlation with Colposcopic and Histological Findings.
Abstract To determine human papillomavirus (HPV) types distribution in cervical lesions in a Southern Italian female population in Messina and their relationship between HPV type and grade of colposcopic and histopathological abnormality, a total of 253 women aged 17-68 years, with previous cytological abnormalities, were included in this study. HPV-DNA testing, colposcopy and biopsy were performed. For each sample, cervical cells were collected by centrifugation and DNA was extracted, followed by a PCR-based HPV-DNA assay and reverse dot blot genotyping. HPV-16 was found the most common type (46.6 %) followed by...
Source: Pathology Oncology Research - February 19, 2013 Category: Pathology Authors: Le Donne M, Giuffrè G, Caruso C, Nicotina PA, Alibrandi A, Scalisi R, Simone A, Chiofalo B, Triolo O Tags: Pathol Oncol Res Source Type: research

Harmony at LAST
The joint College of American Pathologists/American Society for Colposcopy and Cervical Pathology LAST Project provides evidence‐based consensus recommendations for a unified terminology for histopathologic classification of all human papillomavirus–associated squamous lesions of the lower anogenital tract. It also includes specific recommendations for biomarker use to increase reliability and reproducibility of histopathologic diagnoses. (Source: Cancer Cytopathology)
Source: Cancer Cytopathology - February 13, 2013 Category: Pathology Authors: David C. Wilbur, Teresa M. Darragh Tags: Commentary Source Type: research

The Peru Cervical Cancer Prevention Study (PERCAPS): The Technology to Make Screening Accessible.
CONCLUSIONS: Utilizing HPV self-sampling, solid media specimen cards for long distance transport, and centralized high throughput processing, we achieved rapid delivery of results, high satisfaction levels, and low loss to follow-up for cervical cancer screening in remote and transient populations. PMID: 23385153 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - February 2, 2013 Category: Cancer & Oncology Authors: Levinson KL, Abuelo C, Salmeron J, Chyung E, Zou J, Belinson SE, Wang G, Ortiz CS, Vallejos CS, Belinson JL Tags: Gynecol Oncol Source Type: research

Sex After Colposcopy: How Long Should You Wait?
When Pap smear results are abnormal, a colposcopy is often recommended to examine the cervix much closer. A colposcopy is a non-invasive method of of examining the cervix with a special lighted scope. Think of it as a microscope for the vagina, vulva, and cervix. One of the most common questions I receive from women who have recently undergone colpo exams is how long they should wait before having sex. Valid question, but the answer really depends on a few difference factors. Read more about having sex after a colposcopy....Read Full Post (Source: About.com Cancer)
Source: About.com Cancer - January 31, 2013 Category: Cancer & Oncology Source Type: news

Newspath January 2012 - Special Issue: New Cervical Cancer Screening Recommendations Issued by the American Cancer Society, the American Society of Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology
Screening guidelines for cervical cancer were updated in 2012 after the last update in 2002. A structured evidence evaluation process, known as the Grading Recommendations Assessment, Development, and Evaluation (GRADE) system, was utilized to form the new guidelines. (Source: NewsPath - Pathology News for the Medical Community)
Source: NewsPath - Pathology News for the Medical Community - January 31, 2013 Category: Pathology Source Type: news

Newspath January 2013 - Special Issue: New Cervical Cancer Screening Recommendations Issued by the American Cancer Society, the American Society of Colposcopy and Cervical Pathology, and the American Society for Clinical Pathology
Screening guidelines for cervical cancer were updated in 2012 after the last update in 2002. A structured evidence evaluation process, known as the Grading Recommendations Assessment, Development, and Evaluation (GRADE) system, was utilized to form the new guidelines. (Source: NewsPath - Pathology News for the Medical Community)
Source: NewsPath - Pathology News for the Medical Community - January 31, 2013 Category: Pathology Source Type: news

[Articles] Risk of high-grade cervical intraepithelial neoplasia during follow-up in HPV-positive women according to baseline p16-INK4A results: a prospective analysis of a nested substudy of the NTCC randomised controlled trial
p16 overexpression is a marker for CIN2 or worse or for development of CIN2 or worse within 3 years in HPV-positive women, especially those aged 35–60 years. HPV-positive, p16-positive women need immediate colposcopy and, if the assessment is negative, annual follow-up. Immediate colposcopy can be avoided in HPV-positive, p16-negative women, who can be safely managed with repeat screening after 2–3 year intervals. (Source: The Lancet Oncology)
Source: The Lancet Oncology - January 29, 2013 Category: Cancer & Oncology Authors: Francesca Carozzi, Anna Gillio-Tos, Massimo Confortini, Annarosa Del Mistro, Cristina Sani, Laura De Marco, Salvatore Girlando, Stefano Rosso, Carlo Naldoni, Paolo Dalla Palma, Manuel Zorzi, Paolo Giorgi-Rossi, Nereo Segnan, Jack Cuzick, Guglielmo Ronco, Tags: Articles Source Type: research

My laparascopic total vaginal hysterectomy – Samira’s Story
Hi, I wanted to share my experience in the hope it might help others. I had severe and persistent daily bleeding for about 2 years before I decided to have an operation. I had biopsies and tests to check it wasn’t something nasty over that period. Despite the fact I was tired and at some point anaemic I wanted to try non surgical options. I had a Mirena coil inserted and that reduced the severity of bleeding but wouldn’t stop. So I had a 6 month course of norethisterone which stopped the bleeding for 2 weeks out of 4 weeks at a time. Again this was better than before but still hadnt solved the problem. My speci...
Source: The Hysterectomy Association - January 25, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Your Stories laparascopic hysterectomy vaginal hysterectomy Source Type: news

Effect of 2 referral intervals on diagnostic discordance between cytology and histology at a colposcopy clinic
Abstract: Objective: To determine the effect of the time interval between cervical cytology screening and histology at treatment on grade of cervical disease.Methods: In a retrospective cross-sectional study at a colposcopy clinic in Soweto, Johannesburg, South Africa, data were compared from women with cytologic abnormalities referred for colposcopy between April 2003 and June 2010 to determine whether early (≤180days) or late (>180days) referral had an impact on dysplasia grade.Results: In the early and late referral groups, there were 213 (13.43%) and 201 (14.63%) women, respectively, with upgrading of cervical dyspla...
Source: International Journal of Gynaecology and Obstetrics - January 25, 2013 Category: OBGYN Authors: Francois Saayman, Cyril J. Van Gelderen, Pam Michelow, Eunice J. Van Den Berg, Yasmin Adam Tags: Clinical Articles Source Type: research

Performance of ProEx C and PreTect HPV‐proofer E6/E7 mRNA tests in comparison with the hybrid capture 2 HPV DNA test for triaging ASCUS and LSIL cytology
In conclusion, both ProEx C and Proofer have a similar performance profile with a significantly higher specificity but lower sensitivity than HC2 for the detection of CIN 2+. Consequently, although they can reduce colposcopy referral, they will miss a proportion of CIN 2+ cases. This is a major limitation and should be taken into account if these tests are considered for ASCUS or LSIL triage. © 2013 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - January 22, 2013 Category: Pathology Authors: Reza Alaghehbandan, Daniel Fontaine, James Bentley, Nicholas Escott, Prafull Ghatage, Adrian Lear, Francois Coutlee, Samuel Ratnam Tags: Original Article Source Type: research

HPV16 L1 and L2 DNA methylation predicts high grade cervical intraepithelial neoplasia in women with mildly abnormal cervical cytology
Abstract DNA methylation changes in human papillomavirus type 16 (HPV16) DNA are common and might be important for identifying women at increased risk of cervical cancer. Using recently published data from Costa Rica we developed a classification score to differentiate women with cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) from those with no evident high grade lesions. Here we aim to investigate the performance of the score using data from the UK. Exfoliated cervical cells at baseline and six‐months follow‐up were analyzed in 84 women selected from a randomized clinical trial of women undergoing surveillan...
Source: International Journal of Cancer - January 21, 2013 Category: Cancer & Oncology Authors: Attila T Lorincz, Adam R Brentnall, Nataša Vasiljević, Dorota Scibior‐Bentkowska, Alejandra Castanon, Alison Fiander, Ned Powell, Amanda Tristram, Jack Cuzick, Peter Sasieni Tags: Early Detection and Diagnosis Source Type: research

Is a liquid‐based cytology more sensitive than a conventional Pap smear?
Conclusions: The study results support the view that LBC is no more sensitive than Pap smears for the detection of HSIL+ and CIN2+ irrespective of age. LBC decreased the rate of inadequate smears, but increased the rate of low‐grade cytology under the age of 40 years and decreased the total rate of abnormal smears over the age of 40 years. (Source: Cytopathology)
Source: Cytopathology - January 20, 2013 Category: Pathology Authors: K. Sigurdsson Source Type: research

Electrical impedance test may improve cervical neoplasia detection
NEW YORK (Reuters Health) - Adding electrical impedance spectroscopy (EIS) to colposcopy may improve the accuracy of high-grade cervical intraepithelial neoplasia (HG-CIN) detection, a new study suggests. (Source: Modern Medicine)
Source: Modern Medicine - January 9, 2013 Category: Journals (General) Source Type: news

Accuracy of detection of high‐grade cervical intraepithelial neoplasia using electrical impedance spectroscopy with colposcopy
ConclusionsEIS used as an adjunct to colposcopy improves colposcopic performance. The addition of EIS could lead to more appropriate patient management with lower intervention rates. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - January 4, 2013 Category: OBGYN Authors: JA Tidy, BH Brown, TJ Healey, S Daayana, M Martin, W Prendiville, HC Kitchener Tags: Original Article Source Type: research

Accuracy of detection of high-grade cervical intraepithelial neoplasia using electrical impedance spectroscopy with colposcopy.
CONCLUSIONS: EIS used as an adjunct to colposcopy improves colposcopic performance. The addition of EIS could lead to more appropriate patient management with lower intervention rates. PMID: 23289897 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - January 4, 2013 Category: OBGYN Authors: Tidy J, Brown B, Healey T, Daayana S, Martin M, Prendiville W, Kitchener H Tags: BJOG Source Type: research

The utility and management of vaginal cytology after treatment for endometrial cancer.
CONCLUSION: : Colposcopy is not needed after a Pap test result read as atypical squamous cells of undetermined significance or LSIL. LEVEL OF EVIDENCE: : III. PMID: 23262937 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - January 1, 2013 Category: OBGYN Authors: Novetsky AP, Kuroki LM, Massad LS, Hagemann AR, Thaker PH, Powell MA, Mutch DG, Zighelboim I Tags: Obstet Gynecol Source Type: research

Colposcopic photography of genital injury following sexual intercourse in adults - Astrup BS, Lauritsen J, Thomsen JL, Ravn P.
The aim of this study was to evaluate interpretations and the reproducibility of interpretations when looking at colposcopic photographs in a forensic setting, as well as discussing some of the dilemmas and pitfalls of forensic colposcopic photography. A t... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - December 26, 2012 Category: Global & Universal Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

Prevalence of low-risk HPV types and genital warts in women born 1988/89 or 1983/84 -results of WOLVES, a population-based epidemiological study in Wolfsburg, Germany
Conclusions: HC2 was a specific test for the detection of established and potential LR types. In this first WOLVES analysis, HPV6 was the most frequent HPV type and the single LR type linked to disease. The observed GW incidence of 715 per 100,000 fits well with estimates of healthcare providers. Although life risks for GW were lower than in Scandinavian analyses, the societal burden within the WOLVES populations was considerable. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - December 21, 2012 Category: Infectious Diseases Authors: Karl Ulrich PetryAlexander LuytenAnnika JustusAngelika IftnerSarah StrehlkeRenate Schulze-RathThomas Iftner Source Type: research