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The olfactory system is affected by steroid aerosol treatment in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Asthma needs continuous treatment often for years. In humans, some drugs are administered via aerosol, therefore they come in contact with both respiratory and olfactory mucosa. We explored the possibility that antiasthma corticosteroid treatment could influence the olfactory function by passage through the nose. A group of mice was exposed twice daily for 42 days to fluticasone propionate aerosol and was compared with a control group. Olfactory behavior, respiratory mechanics, histology, and immunoreactivity in the olfactory system were assessed. Fluticasone-treated mice were slower in retrieving a piece of hidden food, b...
Source: AJP: Lung Cellular and Molecular Physiology - November 21, 2009 Category: Respiratory Medicine Authors: Mucignat-Caretta, C., Bondi, M., Rubini, A., Calabrese, F., Barbato, A. Tags: ARTICLES Source Type: journals

Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFractureScoresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These new algorithms can predict risk of fracture in primary care populations in the UK without laboratory measurements and are therefore suitable for use in both clinical settings and for self assessment (www.qfracture.org). QFractureScores could be used to identify patients at high risk of fracture who might benefit from interventions to reduce their risk. (Source: BMJ Online First)
Source: BMJ Online First - November 20, 2009 Category: Journals (General) Authors: Hippisley-Cox, J., Coupland, C. Tags: Liver disease, Smoking and tobacco, Epidemiologic studies, General practice / family medicine, Immunology (including allergy), Drugs: cardiovascular system, Menopause (including HRT), Asthma, Connective tissue disease, Degenerative joint disease, Drugs: m Source Type: journals

[Comment] β2-receptor polymorphisms in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In The Lancet today, Michael Wechsler and colleagues, from the Asthma Clinical Research Network (ACRN) of the US National Heart, Lung, and Blood Institute, report the LARGE study of the effects of a single-nucleotide polymorphism of the β2-adrenergic receptor on the addition of the longacting inhaled β2 agonist, salmeterol, to inhaled corticosteroid therapy. These investigators found significant improvements in baseline lung function as measured by morning peak expiratory flow with no genotype difference. They concluded that their data supported the current guideline recommendations for the use of these agonists in conju...
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: H William Kelly Tags: Comment Source Type: journals

[Articles] Effect of β2-adrenergic receptor polymorphism on response to longacting β2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some studies suggest that patients with asthma who are homozygous for arginine at the 16th aminoacid position of the β2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting β2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly). We investigated whether there is a genotype-specific response to treatment with a longacting β2 agonist in combination with inhaled corticosteroid. (Source: LANCET)
Source: LANCET - November 20, 2009 Category: Journals (General) Authors: Michael E Wechsler, Susan J Kunselman, Vernon M Chinchilli, Eugene Bleecker, Homer A Boushey, William J Calhoun, Bill T Ameredes, Mario Castro, Timothy J Craig, Loren Denlinger, John V Fahy, Nizar Jarjour, Shamsah Kazani, Sophia Kim, Monica Kraft, Stephen Tags: Articles Source Type: journals

Responses to combined LABA–ICS therapy differ by COPD subtypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with various subtypes of chronic obstructive pulmonary disease differ in their response to inhaled treatment with a combined long-acting beta-agonist and corticosteroid, Korean study results show. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - November 20, 2009 Category: Respiratory Medicine Source Type: news

A prospective, randomized, multicenter study evaluating early corticosteroid withdrawal with Thymoglobulin® in living-donor kidney transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: rATG with tacrolimus and MMF therapy may allow early elimination of corticosteroids, is associated with trends toward lower lipid levels, less weight gain, and a safety profile comparable to CCST therapy. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 20, 2009 Category: Transplant Surgery Authors: E. Steve Woodle, V. Ram Peddi, Stephen Tomlanovich, Shamkant Mulgaonkar, Paul C. Kuo Source Type: journals

Beta2-receptor polymorphism doesn't seem to affect clinical response to LABA in asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Lancet Area: News Although there were apparent differences in test results, asthmatic patients with different polymorphisms of the beta2-adrenergic receptor had similar clinical responses to the combination or inhaled corticosteroid plus long-acting beta2 agonist (LABA) in a controlled trial. There are genetically-determined variations in the beta2-receptor, with two possible amino acids (glycine, Gly, or arginine, Arg) in the 16 position; there is some evidence that patients who are B16 Arg/Arg may benefit less from LABA treatment than those who are B16 Gly/Gly and a retrospective analysis of clinical ...
Source: NeLM - News - November 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

How childhood stress can lead to adult depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Childhood should be a happy time, not a stressful time—that’s something everyone can agree on. But for many children, childhood is very stressful. Family tragedy, natural disasters, poverty, abuse or exposure to violence (in the home, in the community, or when the country is at war) are just a few examples of what can turn childhood from a dream into a nightmare. This is terrible for children. It’s not just a matter of robbing them of happiness; more and more research is showing that stress early in life can actually change the way a child’s brain works—for life. A study in the journal Nature Neuroscience this mo...
Source: Thrive, Children's Hospital Boston - November 19, 2009 Category: Pediatrics Authors: Claire McCarthy, MD Tags: All posts Claire McCarthy depression PTSD stress stressed kids Source Type: organizations

High dose ICSs in early pregnancy linked to congenital malformationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Children born to women who use high-dose inhaled corticosteroids during early pregnancy may face an increased risk for congenital malformations, results from a Canadian study indicate. (Source: MedWire News - Respiratory)
Source: MedWire News - Respiratory - November 19, 2009 Category: Respiratory Medicine Source Type: news

Alterations in Lung Mast Cell Populations in Patients with COPD.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: As COPD progresses to its severe stages, the mast cell population in the lung undergoes changes in density, distribution, and molecular expression. In COPD lungs, these novel histopathological features were found to be correlated to lung function and they may thus have clinical consequences. PMID: 19926870 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 19, 2009 Category: Respiratory Medicine Authors: Andersson CK, Mori M, Bjermer L, Löfdahl CG, Erjefält JS Tags: Am J Respir Crit Care Med Source Type: journals

Basilea's Toctino(R) Receives Marketing Authorization In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Eczema / Psoriasis Source Type: news

Basilea's Toctino(R) Receives Marketing Authorization In CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Basilea Pharmaceutica Ltd. announces that Toctino® (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained regulatory approval from Health Canada. "We are delighted that Health Canada has approved the use of Toctino for patients with severe chronic hand eczema unresponsive to potent topical steroids. (Source: Dermatology News From Medical News Today)
Source: Dermatology News From Medical News Today - November 18, 2009 Category: Dermatology Tags: Eczema / Psoriasis Source Type: news

Basilea's Toctino(R) receives marketing authorization in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BASEL, SWITZERLAND, Nov 18 -- (HSMN NewsFeed) - Basilea Pharmaceutica Ltd. announces that Toctino (alitretinoin), a new once-daily oral treatment for adults with severe chronic hand eczema (CHE) unresponsive to potent topical corticosteroids, has obtained ... Biopharmaceuticals, RegulatoryBasilea Pharmaceutica, Toctino, alitretinoin, chronic hand eczema (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 18, 2009 Category: Pharmaceuticals Source Type: news

Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dasatinib, a highly potent BCR-ABL inhibitor, is an effective treatment for patients with chronic myeloid leukemia in chronic phase (CML CP) after resistance, suboptimal response, or intolerance to prior imatinib. In a phase 3 dose optimization trial in patients with CML CP (CA180-034), the occurrence of pleural effusion was significantly minimized with dasatinib 100 mg once daily (QD) compared with other treatment arms (70 mg twice daily [twice daily], 140 mg QD, or 50 mg twice daily).To investigate the occurrence and management of pleural effusion during dasatinib treatment, and efficacy in patients with or without pleur...
Source: Cancer - November 18, 2009 Category: Cancer & Oncology Authors: Kimmo Porkka, H. Jean Khoury, Ronald L. Paquette, Yousif Matloub, Ritwik Sinha, Jorge E. Cortes Source Type: journals

Primary cutaneous infection with Scedosporium apiospermum successfully treated with voriconazoleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 61-year-old male patient with a history of long-term corticosteroid treatment for chronic obstructive pulmonary disease, who developed subcutaneous nodules on his right forearm. Histopathologic examination showed large epitheloid cell granulomas with multinuclear giant cells that contained hyphae within their cytoplasm. Microbiological testing of biopsies revealed an infection with Scedosporium apiospermum with resistance to common antifungal agents like fluconazole, itraconazole or amphotericin B and sensitivity to voriconazole. After two months of oral therapy with voriconazole the skin lesions have complet...
Source: Mycoses - November 18, 2009 Category: Research Authors: K. Stur-Hofmann, S. Stos, M. Saxa-Enenkel, K. Rappersberger Source Type: journals

Tacrolimus combined with two different corticosteroid-free regimens compared with a standard triple regimen in renal transplantation: one year observational resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Krämer BK, Klinger M, Wlodarczyk Z, Ostrowski M, Midvedt K, Stefoni S, Citterio F, Pietruck F, Squifflet J-Paul, Segoloni G, Krüger B, Sperschneider H, Banas B, Bäckman L, Weber M, Carmellini M, Perner F, Claesson K, Marcinkowski W, Vítko [Scaron], Senatorski G, Salmela K, Nordström J. Tacrolimus combined with two different corticosteroid-free regimens compared with a standard triple regimen in renal transplantation: one year observational results.Clin Transplant 2009 DOI: 10.1111/j.1399-0012.2009.01162.x© 2009 John Wiley & Sons A/S.Abstract: Side effects of steroid use have led to efforts to minimize their use in tr...
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Bernhard K. Krämer, Marian Klinger, Zbigniew Wlodarczyk, Marek Ostrowski, Karsten Midvedt, Sergio Stefoni, Franco Citterio, Frank Pietruck, Jean-Paul Squifflet, Giuseppe Segoloni, Bernd Krüger, Heide Sperschneider, Bernhard Banas, Lars Bäckman, Markus Source Type: journals

Impact on relapse of corticosteroid therapy after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Imahashi N, Inamoto Y, Seto A, Watanabe K, Nishiwaki S, Yanagisawa M, Shinba M, Yasuda T, Kuwatsuka Y, Atsuta Y, Kodera Y, Miyamura K. Impact on relapse of corticosteroid therapy after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia.Clin Transplant 2009 DOI: 10.1111/j.1399-0012.2009.01158.x© 2009 John Wiley & Sons A/S.Abstract: Corticosteroids are often used following allogeneic hematopoietic stem cell transplantation (HSCT) to control complications such as graft-versus-host disease (GVHD). However, there is some concern that corticosteroids may suppress the graft-versus-leukemia effect and i...
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Nobuhiko Imahashi, Yoshihiro Inamoto, Aika Seto, Keisuke Watanabe, Satoshi Nishiwaki, Mayumi Yanagisawa, Makoto Shinba, Takahiko Yasuda, Yachiyo Kuwatsuka, Yoshiko Atsuta, Yoshihisa Kodera, Koichi Miyamura Source Type: journals

Lower risk of urinary tract infection with low-dose trimethoprim/sulfamethoxazole compared to dapsone prophylaxis in older renal transplant patients on a rapid steroid-withdrawal immunosuppression regimenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For renal transplant recipients over the age of 47 yr, treated without long-term glucocorticoids, our retrospective data suggest that low-dose TMP/SMZ is associated with a lower risk of UTI compared to dapsone prophylaxis. (Source: Clinical Transplantation)
Source: Clinical Transplantation - November 18, 2009 Category: Transplant Surgery Authors: Jeffrey Allen Giullian, Kerri Cavanaugh, Heidi Schaefer Source Type: journals

Pulsed Intravenous Cyclophosphamide and Methylprednisolone Therapy in Refractory Pemphigus.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Pulsed intravenous therapy with cyclophosphamide and methylprednisolone can be an effective treatment for refractory pemphigus but its adverse effects should be considered prior to therapy and closely monitored in patients on treatment. PMID: 19922532 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 18, 2009 Category: Dermatology Authors: Saha M, Powell AM, Bhogal B, Black MM, Groves RW Tags: Br J Dermatol Source Type: journals

Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that the use of vitamin C supplements may be associated with higher risk of age-related cataract among women. PMID: 19923367 [PubMed - as supplied by publisher] (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - November 18, 2009 Category: Nutrition Authors: Rautiainen S, Lindblad BE, Morgenstern R, Wolk A Tags: Am J Clin Nutr Source Type: journals

Bilateral renal inflammatory pseudotumour effectively treated with corticosteroidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Inflammatory pseudotumour (IPT) is a rare disease of unknown cause that most commonly involves the lung but can occur in almost any site in the body. Occurrence in the kidneys is very rare and bilateral renal involvement even rarer. There are 34 previously reported cases in the English-language medical literature between 1966 and 2008. Herein we report a case of IPT infiltrating both kidneys. We have also reviewed the clinical features, radiological findings, treatment and outcome of renal IPT. Clinical features at presentation are commonly non-specific. Features on imaging are inadequate to make a ...
Source: Clinical and Experimental Nephrology - November 17, 2009 Category: Urology & Nephrology Tags: Clinical and Experimental Nephrology Source Type: journals

Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion With early recognition and proper management, including immediate and permanent withdrawal of the culprit agent, accompanied by hospitalization and rehydration and systemic corticosteroids if necessary, the prognosis is good. Content Type Journal ArticleCategory ReviewDOI 10.1007/s00198-009-1097-5Authors P. Musette, Charles Nicolle University Hospital Department of Dermatology and INSERM Unit 905 Rouen FranceM. L. Brandi, University of Florence Department of Internal Medicine Florence ItalyP. Cacoub, AH-HP, Hôpital Pitié Salpétrière, and Université Pierre et Marie Curie Department of In...
Source: Osteoporosis International - November 17, 2009 Category: Orthopaedics Tags: Osteoporosis International Source Type: journals

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interleukin-12 (IL-12) and interleukin-23 (IL-23) are inflammatory cytokines linked to the Th-1 and Th-17 phenotypes associated with Crohn's disease (CD). We investigated the activity and safety of apilimod mesylate (formerly STA-5326), an oral IL-12 and IL-23 inhibitor, in patients with active CD.We performed a multicenter, Phase 2, randomized, double-blinded, placebo-controlled study to evaluate the efficacy of apilimod mesylate in treating 220 adult patients with moderate-to-severe CD (Crohn's Disease Activity Index [CDAI] score 220-450). Patients were stratified according to C-reactive protein (CRP) levels and corticos...
Source: Inflammatory Bowel Diseases - November 17, 2009 Category: Gastroenterology Authors: Bruce E. Sands, Eric W. Jacobson, Thomas Sylwestrowicz, Ziad Younes, Gerald Dryden, Richard Fedorak, Susan Greenbloom Source Type: journals

Quality of life and health-related utility analysis of adults with moderate and severe atopic dermatitis treated with tacrolimus ointment vs. topical corticosteroidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Treatment with 0.1% tacrolimus ointment rather than a standard topical corticosteroid ointment regimen was associated with clinically significant, incremental improvement in QoL, sustained over a 6-month period. A within-trial cost-utility estimate based on study medication cost alone suggests that tacrolimus ointment is highly cost-effective given existing willingness-to-pay thresholds. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - November 17, 2009 Category: Dermatology Authors: CD Poole, C Chambers, R Allsopp, CJ Currie Source Type: journals

Letter by Baker et al regarding article, "benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose-response meta-analysis".Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19917892 [PubMed - in process] (Source: Circulation)
Source: Circulation - November 17, 2009 Category: Cardiology Authors: Baker WL, White CM, Coleman CI Tags: Circulation Source Type: journals

Hiv-related immune reconstitution cryptococcal meningoradiculitis: corticosteroid responseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Brunel, A., Makinson, A., de Champfleur, N. M., Thouvenot, E., Le Moing, V., Lefalher, G., Bonafe, A., Reynes, J. Tags: MRI, Meningitis, Fungal infections, HIV, Spinal cord infection CLINICAL/SCIENTIFIC NOTES Source Type: journals

Pulsed High-Dose Corticosteroids Combined With Low-Dose Methotrexate Treatment in Patients With Refractory Generalized Extragenital Lichen Sclerosus [Observation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients with severe extragenital LS benefit from pulsed high-dose corticosteroids combined with low-dose methotrexate therapy. This combination therapy should be considered in generalized disease, especially disease that is refractory to conventional treatment. (Source: Archives of Dermatology)
Source: Archives of Dermatology - November 16, 2009 Category: Dermatology Authors: Kreuter, A., Tigges, C., Gaifullina, R., Kirschke, J., Altmeyer, P., Gambichler, T. Tags: Dermatology, Dermatologic Disorders, Bullous Diseases, Dermatologic Disorders, Other, Drug Therapy, Drug Therapy, Other Observation Source Type: journals

Steroids Helpful in Autoimmune PancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Corticosteroid therapy is useful in inducing and maintaining remission in patients with symptomatic autoimmune pancreatitis, Japanese researchers report in the November issue of Gut. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 16, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news

Corticosteroids: Spinal epidural lipomatosis in paediatric patients: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

NICE to relax inhaled steroids threshold for COPD patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many more patients with COPD will be prescribed an inhaled corticosteroid under new draft NICE guidelines, which relax the threshold at which they are initiated. (Source: Pulse Today Clinical Updates)
Source: Pulse Today Clinical Updates - November 16, 2009 Category: Primary Care Tags: Picture stories Source Type: info

Pulmonary fibrosis associated with psychotropic drug therapy: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Drug induced lung disease can be rapidly progressive and if drug exposure continues may result in respiratory failure and death. Prompt recognition is critical as drug withdrawal may result in marked resolution of disease. This case highlights sertraline and risperidone as drugs that may, in susceptible individuals, cause diffuse pulmonary fibrosis. (Source: BioMed Central)
Source: BioMed Central - November 16, 2009 Category: Journals (General) Authors: Clare ThorntonToby MaherDavid HansellAndrew NicholsonAthol Wells Source Type: journals

CADTH systematic review and economic evaluation: Long-acting beta 2-agonist and inhaled corticosteroid combination therapy for adult persistent asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: CADTH Area: News The Canadian Agency for Drugs and Technologies in Health (CADTH) has published a health technology assessment report on long-acting beta2-agonist (LABA) and inhaled corticosteroid (ICS) combination therapy, examining the clinical efficacy, safety, and cost-effectiveness of this treatment strategy for adults with persistent asthma. This assessment focuses on LABA-ICS combination therapy and its place in therapy, but also looks at current clinical practice guidelines and the health services impact of different treatment options. The reviewers make the following overall conclusi...
Source: NeLM - Respiratory Medicine - November 16, 2009 Category: Respiratory Medicine Source Type: organizations

Diabetes as a Determinant of Mortality in Cystic Fibrosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Diabetes is increasingly common in cystic fibrosis (CF), but little exists describing its influence on mortality. Using national UK data, this study documents diabetes-specific mortality rates, estimates the impact of diabetes on survival, and estimates population attributable fractions. Methods: This retrospective cohort study identified 8,029 individuals aged 0-65 years from the UK CF Registry (1996-2005). 5,892 patients were included in analyses of mortality rates and 4,234 in analyses of risk factors. We calculated age-adjusted mortality rates using Poisson regression, standardized mortality ratios usin...
Source: Diabetes Care - November 16, 2009 Category: Endocrinology Authors: Chamnan P, Shine BS, Haworth CS, Bilton D, Adler AI Tags: Diabetes Care Source Type: journals

Treatment of Pediatric Localized Scleroderma: Results of a Survey of North American Pediatric Rheumatologists.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Most PR in North America treat localized scleroderma with a combination ofMTX and corticosteroids. However, there is no consensus on specific treatment regimens. There is a need for controlled treatment trials to better determine optimal therapy for this potentially disabling disease. PMID: 19918041 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - November 16, 2009 Category: Rheumatology Authors: Li SC, Feldman BM, Higgins GC, Haines KA, Punaro MG, O'Neil KM Tags: J Rheumatol Source Type: journals

Nephrotic syndrome in adults: diagnosis and management.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nephrotic syndrome may be caused by primary (idiopathic) renal disease or by a variety of secondary causes. Patients present with marked edema, proteinuria, hypoalbuminemia, and often hyperlipidemia. In adults, diabetes mellitus is the most common secondary cause, and focal segmental glomerulosclerosis and membranous nephropathy are the most common primary causes. Venous thromboembolism is a possible complication; acute renal failure and serious bacterial infection are also possible, but much less common. There are no established guidelines on the diagnostic workup or management of nephrotic syndrome. Imaging studies a...
Source: American Family Physician - November 13, 2009 Category: Primary Care Authors: Kodner C Tags: Am Fam Physician Source Type: journals

Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract P-glycoprotein (P-gp) on activated lymphocytes is an adenosine triphosphate (ATP)-binding cassette transporter that causes drug resistance by exclusion of intracellular drugs in patients with active rheumatoid arthritis (RA). However, infliximab with methotrexate (MTX) can overcome P-gp-mediated drug resistance. We encounter patients who cannot continue infliximab or MTX. Here we tested how etanercept affected P-gp-mediated drug resistance in such intractable RA patients. Peripheral lymphocytes of 11 RA patients (3 switched from infliximab and 8 who could not be treated with MTX) were analyzed for P...
Source: Modern Rheumatology - November 13, 2009 Category: Rheumatology Tags: Modern Rheumatology Source Type: journals

Safety Profile of IBD Therapeutics: Infectious RisksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over the last decade, the medical treatment of inflammatory bowel disease (IBD) has been revolutionized, with increasing use of both immunomodulatory and biologic medications. Corticosteroids have increasingly been associated with an elevated risk of serious and opportunistic infections, both independently and in combination with immunomodulator and biologic agents. There are limited data on the infectious risk of immunomodulators. It is unclear if anti-tumor necrosis factor agents increase overall infectious risk in patients with IBD, but the available literature has demonstrated an increased risk of opportunistic infecti...
Source: Gastroenterology Clinics of North America - November 13, 2009 Category: Gastroenterology Authors: Waqqas Afif, Edward V. Loftus Source Type: journals

Homeopathic and conventional therapies for chronic skin diseases: A prospective study on effectiveness and safetyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The treatment of chronic skin diseases with homeopathic remedies appears to be more safe and satisfactory to the patient when compared with conventional medication, with improvement in quality of life and general health up to 2 years after start of the treatment. (Source: European Journal of Integrative Medicine)
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: M. Jong Source Type: journals

Evidence based integrative medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Integrative approaches have played an essential role in the treatment of dermatological diseases since a long time. Many current standard treatments can be considered integrative such as phototherapy, climate therapy (such as staying at high altitude or at the sea), special training on how to handle a disease, special diets and psychological approaches. Furthermore the amount of well-controlled studies on complementary medicine in the treatment of dermatological disorders has increased within the last years. Besides different therapies derive from natural remedies, such as fumaric acid or psoralene (used e.g. in the treatm...
Source: European Journal of Integrative Medicine - November 13, 2009 Category: Complementary Medicine Authors: F. Pfab, J. Huss-Marp, H. Behrendt, U. Darsow, J. Ring Source Type: journals

Lung function at 10 yrs is not improved by early corticosteroid treatment in asthmatic childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lødrup Carlsen KC, Devulapalli CS, Mowinckel P, Håland G, Munthe-Kaas MC, Carlsen K-H. Lung function at 10 yrs is not improved by early corticosteroid treatment in asthmatic children.Pediatr Allergy Immunol 2009.© 2009 John Wiley & Sons A/S Early intervention with inhaled corticosteroid (ICS) treatment for lung function development in childhood is debated. In view of lung function at birth, we aimed to assess if early use of ICS influenced lung function at 10 yrs of age. A 10-yr follow-up study of 614/802 children (mean age 10.9 ± 0.9 yrs) with lung function measurements at birth in the Environment and Childhood Asthma...
Source: Pediatric Allergy and Immunology - November 13, 2009 Category: Allergy & Immunology Authors: Karin C. Lødrup Carlsen, Chandra Sekhar Devulapalli, Petter Mowinckel, Geir Håland, Monica Cheng Munthe-Kaas, Kai-Håkon Carlsen Source Type: journals

Cardiac surgery in a patient with retroperitoneal fibrosis and heart valvulopathy, both due to pergolide medication for Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Retroperitoneal fibrosis is best described as a chronic inflammatory process which may be idiopathic, but can rarely be brought about by medications, such as pergolide, used for treating Parkinson's disease. Pergolide can produce a fibrotic process in heart valves, resulting in valve insufficiency in up to 25 % of cases. Herein we describe the case of a 68-year-old man who received pergolide for 2 years for Parkinson's disease. The patient developed retroperitoneal fibrosis resulting in renal failure from ureteral obstruction necessitating ureteral stenting, as well as significant aortic and mitral valve insufficiency. He ...
Source: Journal of Cardiothoracic Surgery - November 13, 2009 Category: Cardiovascular & Thoracic Surgery Authors: Efstratios ApostolakisNikolaos BaikoussisDimitrios TselikosIoanna KoniariChristos ProkakisEleftherios FokaeasMenelaos Karanikolas Source Type: journals

Reduced basal salivary cortisol in children with asthma and allergic rhinitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Asthmatic children on moderate or high doses of inhaled corticosteroids had reduced salivary cortisol, but co-morbidity of asthma and rhinitis was also associated with reduced cortisol levels. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 13, 2009 Category: Pediatrics Authors: E Bakkeheim, P Mowinckel, KH Carlsen, P Burney, KC Lødrup Carlsen Source Type: journals

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Identification of synovial fluid FOXP3+ Treg with varying intensities of CD25 opens up possibilities for thorough characterisation of this important T-cell subset in the inflammatory compartment. However, only scarce synovial membrane expression of FOXP3 was found even in the absence of overt inflammation, suggesting that the synovial membrane is a site that would benefit therapeutically from Treg expansion. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Raghavan, S, Cao, D, Widhe, M, Roth, K, Herrath, J, Engstrom, M, Roncador, G, Banham, A H, Trollmo, C, Catrina, A I, Malmstrom, V Tags: Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes Basic and translational research Source Type: journals

Efficacy and safety of steroid injections for shoulder and elbow tendonitis: a meta-analysis of randomised controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Steroid injections are well tolerated and more effective for tendonitis in the short-term than pooled other treatments, though similar to NSAIDs. No long-term benefit was shown. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - November 12, 2009 Category: Rheumatology Authors: Gaujoux-Viala, C, Dougados, M, Gossec, L Tags: Unlocked, Pain (neurology), Physiotherapy, Biological agents, Drugs: musculoskeletal and joint diseases, Physiotherapy, Epidemiology Clinical and epidemiological research Source Type: journals

Severe Asthma Attacks in Kids Averted by Fluticasone/Salmeterol ComboEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In asthmatic children, treatment with fluticasone plus salmeterol is associated with fewer serious exacerbations and lower medical costs compared to the use of an inhaled corticosteroid (ICS) plus montelukast. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 12, 2009 Category: Consumer Health News Tags: Allergy & Clinical Immunology Source Type: news

Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There is no standard therapy for steroid-refractory chronic graft-versus-host disease (GVHD). This problem is particularly daunting in children with chronic GVHD, whereby the effects of the disease and its treatment may impair normal growth and development. Children are also particularly vulnerable to failure and/or toxicity of therapy; for example, joint contractures or joint damage may result in life-long disability. The Pediatric Blood and Marrow Transplant Consortium performed a phase 2 trial of pentostatin for steroid-refractory chronic GVHD in 51 children (median age, 9.8 years) from 24 institutions. Overall response...
Source: Blood - November 12, 2009 Category: Hematology Authors: Jacobsohn, D. A., Gilman, A. L., Rademaker, A., Browning, B., Grimley, M., Lehmann, L., Nemecek, E. R., Thormann, K., Schultz, K. R., Vogelsang, G. B. Tags: Transplantation, Free Research Articles, Clinical Trials and Observations Source Type: journals

How I treat mycosis fungoides and Sezary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The most common subtypes of primary cutaneous T-cell lymphomas are mycosis fungoides (MF) and Sézary syndrome (SS). The majority of patients have indolent disease; and given the incurable nature of MF/SS, management should focus on improving symptoms and cosmesis while limiting toxicity. Management of MF/SS should use a "stage-based" approach; treatment of early-stage disease (IA-IIA) typically involves skin directed therapies that include topical corticosteroids, phototherapy (psoralen plus ultraviolet A radiation or ultraviolet B radiation), topical chemotherapy, topical or systemic bexarotene, and radiotherapy. S...
Source: Blood - November 12, 2009 Category: Hematology Authors: Prince, H. M., Whittaker, S., Hoppe, R. T. Tags: How I Treat, Free Research Articles, Lymphoid Neoplasia Source Type: journals

ACAAI: Fluticasone Plus Salmeterol Cuts Exacerbations in Asthma (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MIAMI BEACH (MedPage Today) -- Researchers reported here that pediatric patients with asthma treated with fluticasone propionate plus salmeterol in a fixed dose combination experienced fewer serious asthma exacerbations and lower costs when compared to the use of inhaled corticosteroids plus montelukast. (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - November 12, 2009 Category: Respiratory Medicine Source Type: news

Outcome of Stevens Johnson syndrome and toxic epidermal necrolysis treated with corticosteroidsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rijal Arpana, Agrawal SIndian Journal of Dermatology, Venereology, and Leprology 2009 75(6):613-614 (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Rijal Arpana, Agrawal S Source Type: journals