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Newborn hearing screening on infants at riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our selected hearing screening on infants at risk allowed 60 deaf children access to early management. However, too many children were lost to follow up; which revealed that better information regarding risk of hearing loss must be provided to parents and paramedics and universal newborn screening needs to be performed. The most important result of this study is that in a population of hearing impaired children, with an impairment incidence close to what is commonly reported, the association of several risk factors proves to be a significant additional risk factor for hearing impairment. (Source: International ...
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Christine Ohl, Liliane Dornier, Cécile Czajka, Jean-Claude Chobaut, Laurent Tavernier Tags: Research papers Source Type: journals

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:Hyperkalaemia caused by increased potassium intake of various "sports" and "detox" drinks http://bit.ly/2iQMgGPeople who have had repeated flu infections or repeated flu vaccines may have some protection against H1N1 influenza http://bit.ly/DdXBm )The Healthiest And Unhealthiest States in America: Lists & Rankings http://bit.ly/3abpwOCost of happiness discovered by Australian economist http://bit.ly/2Y6nBI'Fearless' 3-Ye...
Source: Clinical Cases and Images - November 18, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Establishment, characterization, virus susceptibility and transfection of cell lines from cobia, Rachycentron canadum (L.), brain and finEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Establishment and characterization of two cobia, Rachycentron canadum, cell lines derived from cobia brain (CB) and cobia fin (CF) are described. Caudal fin and brain from juvenile cobia were dissociated for 30 and 10 min, respectively, in phosphate-buffered saline containing 0.25% trypsin at 25 °C. The optimal culture condition for both dissociated cells (primary cell culture) was at 28 °C in Leibovitz-15 medium containing 10% foetal bovine serum. The cells have been sub-cultured at a ratio of 1:2 for more than 160 passages over a period of 3 years. Origin of the cultured cells was verified by comparison of their sequen...
Source: Journal of Fish Diseases - November 18, 2009 Category: Zoology Authors: T-C Cheng, Y-S Lai, I-Y Lin, C-P Wu, S-L Chang, T-I Chen, M-S Su Source Type: journals

Successful Immunotherapy of HCMV Disease Using Virus-Specific T Cells Expanded from an Allogeneic Stem Cell Transplant RecipientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Opportunistic infection remains the principal cause of mortality in allogeneic stem cell transplant recipients with active extensive chronic graft-versus-host disease. Human cytomegalovirus (HCMV) represents an important cause of disease in this setting and the toxicity of protracted and recurrent antiviral treatment together with eventual drug resistance represents a significant limitation to therapy. Although the expansion and adoptive transfer of HCMV-specific T cells from the healthy original donor can be an effective strategy to control viral replication, this is not possible when donors are seronegative or are subseq...
Source: American Journal of Transplantation - November 17, 2009 Category: Transplant Surgery Authors: G. R. Hill, S.-K. Tey, L. Beagley, T. Crough, J. A. Morton, A. D. Clouston, P. Whiting, R. Khanna Source Type: journals

Rituximab: Fatal cytomegalovirus pneumonitis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Cytomegalovirus‐Specific T Cell Immunotherapy Promotes Restoration of Durable Functional Antiviral Immunity following Allogeneic Stem Cell TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These data confirm the ability of cellular immunotherapy to hasten reconstitution of antiviral immunity following allogeneic transplantation, indicating that significant clinical benefits may be conferred in terms of reduction of secondary viral infection episodes, potentially reducing exposure to the toxicities of antiviral drugs. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Relationship of Reconstituted Adaptive and Innate Cytomegalovirus (CMV)–Specific Immune Responses with CMV Viremia in Hematopoietic Stem Cell Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. To our knowledge, this is the first study to prospectively compare multiple measures of innate and adaptive immune responses in hematopoietic stem cell transplant recipients with CMV viremia. The strongest immune correlates with protection against CMV viremia in hematopoietic stem cell transplant recipients are reconstitution of CMV‐specific T cell memory responses (LPA) and recovery of natural killer cell function. In contrast, positive CMV‐LPA before transplantation may be a marker of high risk of CMV reactivation after transplantation. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Direct assessment of cytomegalovirus transfusion-transmitted risks after universal leukoreduction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Among all 46 baseline seronegative recipients and 1316 evaluable transfusions, the calculated overall CMV-TTD risk was up to 6.5% (95% confidence interval [CI], 1.0%-18.0%) in terms of TRs and up to 0.23% (95% CI, 0.06%-0.62%) in terms of non-CMV-screened leukoreduced cellular products. In summary, after universal leukoreduction, CMV-TTD, while uncommon, may still occur. PMID: 19912585 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 13, 2009 Category: Hematology Authors: Wu Y, Zou S, Cable R, Dorsey K, Tang Y, Hapip CA, Melmed R, Trouern-Trend J, Wang JH, Champion M, Fang C, Dodd R Tags: Transfusion Source Type: journals

Negative pretransplant serostatus for Toxoplasma gondii is associated with impaired survival after heart transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic Toxoplasma gondii infection is known to trigger potentially adverse immunoregulatory changes, but limited data exist on long-term implications for heart transplant (HTX) recipients. We evaluated the risk of all cause mortality regarding T. gondii serostatus prior to HTX. Pre-HTX T. gondii serostatus was obtained in 344 recipients and 294 donors. Mean age was 52.1 ± 10.2 years and mean follow-up time after HTX was 5.7 (±5.5, median 3.5) years. All seronegative patients received prophylaxis with pyrimethamine/sulfomethoxazole or cotrimoxazol for 6 months after transplantation. Multivariate survival analysis adjuste...
Source: Transplant International - November 11, 2009 Category: Transplant Surgery Authors: Andreas O. Doesch, Kerstin Ammon, Mathias Konstandin, Sultan Celik, Arnt Kristen, Lutz Frankenstein, Susanne Müller, Falk-Udo Sack, Hugo A. Katus, Thomas J. Dengler Source Type: journals

Mixed CMV Infection Boosts Virulence in Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infection with multiple cytomegalovirus (CMV) strains harboring different glycoprotein B (gB) polymorphisms may increase time to clearance in solid-organ transplant recipients. Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - November 10, 2009 Category: Transplant Surgery Tags: Infectious Diseases Source Type: info

Infectious Burden and Risk of Stroke: The Northern Manhattan Study [Original Contribution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A quantitative weighted index of infectious burden was associated with risk of first stroke in this cohort. Future studies are needed to confirm these findings and to further define optimal measures of infectious burden as a stroke risk factor.Published online November 9, 2009 (doi:10.1001/archneurol.2009.271). (Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: Elkind, M. S. V., Ramakrishnan, P., Moon, Y. P., Boden-Albala, B., Liu, K. M., Spitalnik, S. L., Rundek, T., Sacco, R. L., Paik, M. C. Tags: Bacterial Infections, Viral Infections, Neurology, Cerebrovascular Disease, Stroke, Infectious Diseases Original Contribution Source Type: journals

Association of cytomegalovirus infections with recurrence of humoral and cellular autoimmunity to islet autoantigens and of type 1 diabetes in a pancreas transplanted patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Association of type 1 diabetes and cytomegalovirus (CMV) is suspected and CMV infections have also been linked to increased risk of new onset post-transplantation diabetes. We monitored response to islet autoantigens, pancreatic endocrine function, and CMV infections in one type 1 diabetic patient receiving pancreas allograft. Time course analyses of levels of islet autoantibodies (Abs), IFN-[gamma] ELISPOT response, analysis of T cell function, levels of C peptide together with CMV pp65 antigenaemia and viraemia and graft biopsy histopathology were performed in comparison with a cohort of diabetic recipients. Evidence of ...
Source: Transplant International - November 9, 2009 Category: Transplant Surgery Authors: Maria M. Zanone, Enrica Favaro, Roberto Quadri, Ilaria Miceli, Fulvia Giaretta, Renato Romagnoli, Ezio David, Paolo Cavallo Perin, Mauro Salizzoni, Giovanni Camussi Source Type: journals

Phase II Study of Alemtuzumab in Combination With Pentostatin in Patients With T-Cell Neoplasms [Hematologic Malignancies]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The combination of alemtuzumab and pentostatin is feasible and effective in T-cell neoplasms. Although infections, including cytomegalovirus reactivation, are a concern, they may be minimized with adequate prophylactic antibiotic therapy. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - November 6, 2009 Category: Cancer & Oncology Authors: Ravandi, Aribi, O'Brien, Faderl, Jones, Ferrajoli, Huang, York, Pierce, Wierda, Kontoyiannis, Verstovsek, Pro, Fayad, Keating, Kantarjian Tags: Combined Therapy Hematologic Malignancies Source Type: journals

Cytomegalovirus-specific CD8+ T cells targeting different HLA/peptide combinations correlate with protection but at different threshold frequenciesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytomegalovirus (CMV) causes significant morbidity and mortality in patients after haematopoietic stem cell transplantation (HSCT). Due to limitations of current antiviral therapies, alternative approaches, involving transfer of donor-derived CMV-specific CD8+ T cells, have been considered. Levels of such cells correlating with protection against CMV infection and disease have only been reported in patients expressing HLA-A*0201 and HLA-B*0702. This is despite an increasing number of reports describing cells targeting CMV peptides presented by other human leucocyte antigens (HLAs). Considering several frequent HLA alleles,...
Source: British Journal of Haematology - November 6, 2009 Category: Hematology Authors: Sandra Giest, Sarah Grace, Alexandra C. Senegaglia, Ricardo Pasquini, Rosa M. Gonzalo-Daganzo, Manuel N. Fernández, Stephen Mackinnon, J. Alejandro Madrigal, Paul J. Travers Source Type: journals

Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4+ perforin expressing T cells enriched for human cytomegalovirus specificity and an effector-memory phenotypeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously shown an expansion of cytotoxic antigen-experienced CD4+T cells (CTLs) that express perforin (PF) in the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL). Increased frequencies of CD4+CTLs have since been attributed to chronic viral infections, particularly, human cytomegalovirus (HCMV). The present study examined the involvement of CD4+CTLs in responses to HCMV in B-CLL, and characterized their differentiation. We studied 36 HCMV seropositive (SP) and seronegative B-CLL patients and 20 healthy age-matched individuals. The HCMV reactivity of CD4+PF+ and CD4+PF[minus] cells w...
Source: British Journal of Haematology - November 6, 2009 Category: Hematology Authors: James A. Walton, Peter M. Lydyard, Amit Nathwani, Vincent Emery, Arne Akbar, Martin J. Glennie, Nino Porakishvili Source Type: journals

Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R geneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The tightly regulated production of distinct erythrocyte protein 4.1R isoforms involves differential splicing of 3 mutually exclusive first exons (1A, 1B, 1C) to the alternative 3' splice sites (ss) of exon 2'/2. Here, we demonstrate that exon 1 and 2'/2 splicing diversity is regulated by a transcription-coupled splicing mechanism. We also implicate distinctive regulatory elements that promote the splicing of exon 1A to the distal 3' ss and exon 1B to the proximal 3' ss in murine erythroleukemia cells. A hybrid minigene driven by cytomegalovirus promoter mimicked 1B-promoter–driven splicing patterns but differed from...
Source: Blood - November 5, 2009 Category: Hematology Authors: Huang, S.-C., Cho, A., Norton, S., Liu, E. S., Park, J., Zhou, A., Munagala, I. D., Ou, A. C., Yang, G., Wickrema, A., Tang, T. K., Benz, E. J. Tags: Red Cells, Iron, and Erythropoiesis Source Type: journals

The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the role of the HCMV UL111A gene, which encodes homologs of the immunosuppressive cytokine interleukin-10 in the context of latent infection of myeloid progenitor cells. A UL111A deletion virus was able to establish, maintain, and reactivate from experimental latency in a manner comparable with parental virus, but major histocompatibility complex class II levels increased significantly on the surfaces of cells infected with the deletion virus. Importantly, there was an increase in both allogeneic and autologous peripheral blood mononuclear cells and CD4+ T-cell responses to UL111A deletion virus-infected myeloi...
Source: Blood - November 5, 2009 Category: Hematology Authors: Cheung, A. K. L., Gottlieb, D. J., Plachter, B., Pepperl-Klindworth, S., Avdic, S., Cunningham, A. L., Abendroth, A., Slobedman, B. Tags: Immunobiology Source Type: journals

Chromatinisation of herpesvirus genomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The double-stranded DNA genomes of herpesviruses exist in at least three alternative global chromatin states characterised by distinct nucleosome content. When encapsidated in virus particles, the viral DNA is devoid of any nucleosomes. In contrast, within latently infected nuclei herpesvirus genomes are believed to form regular nucleosomal structures resembling cellular chromatin. Finally, during productive infection nuclear viral DNA appears to adopt a state of intermediate chromatin formation with irregularly spaced nucleosomes. Nucleosome occupancy coupled with posttranslational histone modifications and other epigenet...
Source: Reviews in Medical Virology - November 5, 2009 Category: Virology Authors: Christina Paulus, Alexandra Nitzsche, Michael Nevels Source Type: journals

Gammadelta T Lymphocytes Producing Ifngamma and Il-17 In Response To Candida Albicans Or Mycobacterial Antigens: Possible Implications For Acute And Chronic Inflammation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
T lymphocytes bearing the gammadelta T cell receptor are known to play an important role in the first-line defense against viral, bacterial and fungal pathogens. Two main subsets of gammadelta T cells are known, showing distinct functional behaviour: Vdelta2 T lymphocytes, circulating in the peripheral blood, are involved in the response to mycobacterial infections and certain viruses, including coxsakie virus B3 and herpes simplex virus type 2. Vdelta1 T cells are resident in the mucosal-associated lymphoid tissue and are reported to participate in the immunity against Listeria monocytogenes and cytomegalovirus. Vdelt...
Source: Current Medicinal Chemistry - November 5, 2009 Category: Chemistry Authors: Poggi A, Catellani S, Musso A, Zocchi MR Tags: Curr Med Chem Source Type: journals

Treatment strategies to minimize or prevent chronic allograft dysfunction in pediatric renal transplant recipients: an overview.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Long-term allograft survival poses a major problem in pediatric renal transplantation, with allograft nephropathy being the principal cause of graft failure after the first post-transplant year. The mechanisms of nephron loss resulting in graft dysfunction are multiple, comprising both immunologic factors such as acute and chronic antibody- or T-cell-mediated rejection and non-immunologic components. The latter include peri-transplant injuries and renovascular lesions (renal artery stenosis, thrombosis) as well as cardiovascular risk factors such as arterial hypertension and hyperlipidemia. Another relevant issue leadi...
Source: Paediatric Drugs - November 4, 2009 Category: Pediatrics Authors: Höcker B, Tönshoff B Tags: Paediatr Drugs Source Type: journals

Clinical Predictors of Relapse after Treatment of Primary Gastrointestinal Cytomegalovirus Disease in Solid Organ Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, an extensive involvement of the gastrointestinal tract was significantly associated with CMV relapse. However, endoscopic evidence of resolution of gastrointestinal disease did not necessarily translate into a lower risk of CMV relapse. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - November 4, 2009 Category: Transplant Surgery Authors: A. J. Eid, S. K. Arthurs, P. J. Deziel, M. P. Wilhelm, R. R. Razonable Source Type: journals

Is Routine TORCH Screening Warranted in Neonates with Lenticulostriate Vasculopathy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Routinely applied efforts to diagnose congenital infections in cases presenting with LSV have a poor yield. Routine TORCH screening in neonates with LSV cases should only be regarded as mandatory once well-designed studies demonstrate a clear diagnostic benefit. PMID: 19887856 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - November 4, 2009 Category: Perinatology & Neonatology Authors: de Jong EP, Lopriore E, Vossen AC, Steggerda SJ, Te Pas AB, Kroes AC, Walther FJ Tags: Neonatology Source Type: journals

Response to Dr Derhovanessian “Impact of cytomegalovirus infection on immune signatures in cancer patients”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the editorDOI 10.1007/s00262-009-0787-3Authors Yen-Ta Lu, Mackay Memorial Hospital Medical Research Department No. 45, Minsheng Rd., Tamsui Town Taipei 25160 TaiwanI-Hsuan Chen, Mackay Memorial Hospital Medical Research Department No. 45, Minsheng Rd., Tamsui Town Taipei 25160 Taiwan Journal Cancer Immunology, ImmunotherapyOnline ISSN 1432-0851Print ISSN 0340-7004 (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - November 3, 2009 Category: Cancer & Oncology Tags: Cancer Immunology, Immunotherapy Source Type: journals

The Effect of Imatinib on Cytomegalovirus Reactivation in Hematopoietic Cell TransplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. In vitro studies have shown possible antiviral effects of tyrosine kinase inhibitors. In a retrospective study, we show that use of the tyrosine kinase inhibitor imatinib does not appear to reduce cytomegalovirus reactivation during the first 100 days after transplantation in a cohort of hematopoietic cell transplant recipients. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 3, 2009 Category: Infectious Diseases Tags: article BRIEF REPORT Source Type: journals

Bowels Of Infection: Cytomegalovirus Infection May Exacerbate Inflammatory Bowel DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New research suggests that latent cytomegalovirus infection may exacerbate inflammatory bowel disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 3, 2009 Category: Science Source Type: news

The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we investigate the relationship between plasmid release kinetics and the extent and duration of transgene expression. Scaffolds were fabricated from polymer microspheres modified with cationic polymers (polyethylenimine, poly(l-lysine), poly(allylamine hydrochloride), polydiallyldimethylammonium) or polydopamine (PD), with PD enhancing incorporation and slowing release. In vivo implantation of scaffolds into the peritoneal fat pad had no significant changes in the level and duration of transgene expression between PD and unmodified scaffolds. Control studies with plasmid dried onto scaffolds, which exhibite...
Source: Biomaterials - November 3, 2009 Category: Materials Science Authors: Avilés MO, Lin CH, Zelivyanskaya M, Graham JG, Boehler RM, Messersmith PB, Shea LD Tags: Biomaterials Source Type: journals

Infectious antibodies in systemic lupus erythematosus patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Infections can act as environmental triggers that induce or promote systemic lupus erythematosus (SLE) in genetically predisposed individuals. New technologies, developed recently, enable simultaneous assessment of multiple antibodies. Antibodies to specific infectious agents may shed light into the mechanisms of induction of SLE. The aim of this study was to investigate the prevalence of seropositivity and the titers of antibodies to bacterial, viral, and parasitic agents in SLE patients compared with non-autoimmune controls. Sera from 260 individuals (120 SLE patients and 140 controls) were tested by the BioPlex 2200...
Source: Lupus - November 1, 2009 Category: Rheumatology Authors: Berkun Y, Zandman-Goddard G, Barzilai O, Boaz M, Sherer Y, Larida B, Blank M, Anaya JM, Shoenfeld Y Tags: Lupus Source Type: journals

Allograft rejection-related gene expression in the endothelial cells of renal transplantation recipients after cytomegalovirus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CMV could up-regulate the expression levels of ICAM-1 and MHC antigens, which was closely related to allograft rejection. PMID: 19882756 [PubMed - in process] (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - November 1, 2009 Category: Science Authors: Li Y, Yan H, Xue WJ, Tian PX, Ding XM, Pan XM, Feng XS, Tian XH, Xiang HL, Hou J Tags: J Zhejiang Univ Sci B Source Type: journals

Induction With and Without Antithymocyte Globulin Combined With Cyclosporine/Tacrolimus-Based Immunosuppression in Renal Transplantation: A Meta-analysis of Randomized Controlled TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Based on available data induction with ATG was more efficient to reduce the rate of acute rejection episodes and chronic rejection responses after renal transplantation, but was associated with increased side effects, particularly CMV infections. It is important to provide the most benefit for an individual patient. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: J.H. Tian, X. Wang, K.H. Yang, A.P. Liu, X.F. Luo, J. Zhang Tags: Renal Transplantation Source Type: journals

Relationship Between HLA Tissue Type, CMV Infection, and Acute Graft-vs-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation: Single-Center ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, it seems that certain HLA alleles may have either a protective or predisposing role in CMV reactivation, which might be helpful in estimating the risk of aGvHD and designing individualized therapy. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: C. Kekik, S.K. Besisik, Y. Seyhun, F.S. Oguz, D. Sargin, M.N. Carin Tags: Bone Marrow and Stem Cell Transplantation Source Type: journals

Postural Epigastric Pain as a Sign of Cytomegalovirus Gastritis in Renal Transplant Recipients: A Case-Based ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Postural epigastric pain as a sign of CMV gastritis is fairly rare in renal transplant recipients. To our knowledge this is the third article presented in the literature so far. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: W. Li, H. Fan, L. Yiping Tags: Case Reports Source Type: journals

False positive immunoglobulin m antibody to cytomegalovirus in child with infectious mononucleosis caused by epstein-barr virus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 16-month-old boy was admitted because of cough that had lasted for 10 days. The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus (CMV). On the basis of seroconversion to Epstein-Barr nuclear antigen (EBNA) Ig G positivity and reduced CMV Ig M titer with persistently negative CMV Ig G, a definite diagnosis of EBV-induced infectious mononucleosis was established 1 year 2 month later. PMID: 19881978 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 31, 2009 Category: Universities & Medical Training Authors: Park JM, Shin JI, Lee JS, Jang YH, Kim SH, Lee KH, Lee CH Tags: Yonsei Med J Source Type: journals

Growth and development of infants with asymptomatic congenital cytomegalovirus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: 1) An elevated threshold in the V wave was present in asymptomatically infected infants, but could not be detected through otoacoustic emission (OAE) screening. 2) Either in the neonatal or infant periods, asymptomatic congenital HCMV infection did not have a significant influence on nervous behavior or on physical and intellectual development. PMID: 19881970 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 31, 2009 Category: Universities & Medical Training Authors: Shan R, Wang X, Fu P Tags: Yonsei Med J Source Type: journals

Structure characterization of human cytomegalovirus UL131A, UL130 and UL128 genes in clinical strains in China.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the structure of these three genes in HCMV. Eighteen low-passage clinical isolates and five non-passage strains from congenitally HCMV-infected infants in China were used to assess the structures of the UL131A, UL130, and UL128 genes and to find possible relationships between sequence polymorphism and different signs of HCMV disease. Comparisons were made between the UL131A, UL130, and UL128 genes of clinical strains and published sequences of Towne and Merlin strains. The UL131A coding region in the clinical strains was similar to that of Towne and Merlin strains, while UL130, and UL128 coding regions in the c...
Source: Genetics and Molecular Research - October 30, 2009 Category: Genetics & Stem Cells Authors: Sun ZR, Ji YH, Ruan Q, He R, Ma YP, Qi Y, Mao ZQ, Huang YJ Tags: Genet Mol Res Source Type: journals

Crystallization and preliminary X-ray crystallographic characterization of a public CMV-specific TCR in complex with its cognate antigenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The T-cell response to human cytomegalovirus is characterized by a dramatic reduction of clonal diversity in patients undergoing chronic inflammation or immunodepression. In order to check whether all the selected high-avidity T-cell clones recognize the immunodominant pp65 peptide antigen pp65495–503 (NLVPMVATV) presented by the major histocompatibility complex (MHC) molecule HLA-A2 in a similar manner, several public high-affinity T-cell receptors (TCRs) specific for the pp65495–503–HLA-A2 complex have been investigated. Expression, purification and crystallization were performed and preliminary crystallographic da...
Source: Acta Crystallographica Section F - October 30, 2009 Category: Biochemistry Authors: Reiser, J.-B.Legoux, F.Machillot, P.Debeaupuis, E.Le Moullac-Vaydie, B.Chouquet, A.Saulquin, X.Bonneville, M.Housset, D. Tags: T-cell receptors human cytomegalovirus HLA-A2 public response affinity selection crystallization communications Source Type: journals

Value of anti-infective chemoprophylaxis in primary systemic vasculitis.What is the evidence?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although infections are a major concern in patients with primary systemic vasculitis the actual knowledge about risk factors and the evidence concerning the use of anti-infective prophylaxis from clinical trials are scarce. The use of high dose glucocorticoids and cyclophosphamide pose a definite risk for infections. Bacterial infections are among the most frequent causes of death, with Staph. aureus being the most common isolate. Concerning viral infections cytomegalovirus and varicella-zoster virus reactivation represent the most frequent complications. The only prophylactic measure which is widely accepted is trimethopr...
Source: Arthritis Research and Therapy - October 28, 2009 Category: Rheumatology Authors: Frank MoosigJulia HolleWolfgang Gross Source Type: journals

Cytomegalovirus retinitis associated with Good's syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. CMV retinitis can be associated with Good’s syndrome. PMID: 19882506 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - October 28, 2009 Category: Opthalmology Authors: Mateo-Montoya A, Stanescu D, Wolff B, Sahel JA, Bonnel S Tags: Eur J Ophthalmol Source Type: journals

Comprehensive analyses and characterization of haemophagocytic lymphohistiocytosis in Vietnamese childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the majority of HLH cases are associated with virus infections in Vietnamese children. Familial HLH is rare. The frequent reactivation and high mortality demands a more appropriate therapeutic regimen in tropical areas like Vietnam. (Source: British Journal of Haematology)
Source: British Journal of Haematology - October 27, 2009 Category: Hematology Authors: Lam T. My, Le B. Lien, Wen-Chuan Hsieh, Toshihiko Imamura, Tran N. K. Anh, Phan N. L. Anh, Nguyen T. Hung, Fan-Chen Tseng, Chia-Yu Chi, Ngo T. H. Dao, Duong T. M. Le, Le Q. Thinh, Tran T. Tung, Shinsaku Imashuku, Tang C. Thuong, Ih-Jen Su Source Type: journals

Primary Antifungal Prophylaxis in Adult Hematopoietic Stem Cell Transplant Recipients: Current Therapeutic ConceptsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacotherapy 29(11): 1306-1325 Abstract In recipients of hematopoietic stem cell transplants (HSCTs), the mortality associated with invasive fungal infections (IFIs) remains high, despite the introduction of broad-spectrum antifungal agents over the past 2 decades. Preventing exposure to fungal pathogens in this population is impossible; therefore, clinicians have focused on prophylactic use of antifungal agents to prevent IFIs in high-risk HSCT recipients. It is important to target antifungal prophylaxis by type of HSCT (autologous or allogeneic), local epidemiology, and risk factors for IFIs so that patients can recei...
Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy - October 26, 2009 Category: Drugs & Pharmacology Authors: Dorothy McCoyDaryl D DePestelPeggy L Carver Source Type: journals

An AIDS patient with immune reconstitution inflammatory syndrome due to pulmonary Mycobacterium kansasii infection during antiretroviral therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract After the recovery of pneumocystis pneumonia, amebiasis, and cytomegalovirus duodenal ulcer in a patient with AIDS, antiretroviral therapy was initiated. Fever was first noted on the 11th day of administration of the highly active antiretroviral therapy (HAART), and chest radiography showed infiltration into the right lower lobe of the lung on the 19th day. Bronchoscopy was performed, with a tentative diagnosis of pulmonary tuberculosis, but Mycobacterium kansasii was eventually identified. M. kansasii may also be a pathogenic organism causing immune reconstitution inflammatory syndrome. Content T...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Vitamin D and the risk of acute allograft rejection following human liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to assess the relationship between acute liver allograft cellular rejection (ACR) and pretransplant serum vitamin D concentration or post-transplant vitamin D supplementation. We studied 133 LT recipients who underwent two per protocol allograft biopsies in the early post-operative period, plus on-demand biopsies as clinically indicated. ACR estimate was given according to the Banff scheme in biopsies obtained along two follow-up periods: (a) from the transplant operation to the end of the second month (0[ndash]2 months); (b) and from the third month to the end of the eighth month (3[ndash]8 months) post-L...
Source: Liver International - October 22, 2009 Category: Gastroenterology Authors: Davide Bitetto, Carlo Fabris, Edmondo Falleti, Ezio Fornasiere, Elisa Fumolo, Elisabetta Fontanini, Annarosa Cussigh, Giuseppa Occhino, Umberto Baccarani, Mario Pirisi, Pierluigi Toniutto Source Type: journals

Pseudomembranous Aspergillus tracheobronchitis in a heart transplant recipientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a patient who received a heart transplant (HT) because of cardiac amyloidosis and who developed pseudomembranous AT. Possible risk factors concurrent in this case were splenectomy, lymphocytopenia, and previous cytomegalovirus infection. Chest computed tomography scan showed thickening of the left bronchi and a 'tree-in-bud' pattern with multiple small nodules. Bronchoscopic examination revealed raised yellowish pseudomembranous plaques on the tracheobronchial tree. Bronchoalveolar lavage and aspirate cultures yielded Aspergillus fumigatus. The patient recovered with voriconazole. Clinicians should be...
Source: Transplant Infectious Disease - October 21, 2009 Category: Transplant Surgery Authors: A. Ramos, J. Segovia, M. Gómez-Bueno, C. Salas, M.T. Lázaro, I. Sanchez, L. Pulpón Source Type: journals

The Bowels Of InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Current research suggests that latent cytomegalovirus (CMV) infection may exacerbate inflammatory bowel disease (IBD). The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of The American Journal of Pathology. CMV infects between 50% and 80% of adults in the United States. (Source: Irritable-Bowel Syndrome News From Medical News Today)
Source: Irritable-Bowel Syndrome News From Medical News Today - October 21, 2009 Category: Gastroenterology Tags: Irritable-Bowel Syndrome Source Type: news

The bowels of infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(American Journal of Pathology) Current research suggests that latent cytomegalovirus infection may exacerbate inflammatory bowel disease. The related report by Onyeagocha et al, "Latent cytomegalovirus infection exacerbates experimental colitis," appears in the November 2009 issue of the American Journal of Pathology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 21, 2009 Category: Global & Universal Source Type: news

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drug resistant strains of human cytomegalovirus (HCMV) in patients at risk may increasingly develop into a problem in the clinical setting. Genotypic resistance testing is becoming the method of choice, but requires previous phenotypic characterisation of each newly found mutation. In order to facilitate the interpretation of the patient's CMV sequence data, a web based search tool was generated that links the sequence to a database containing all published UL97 (protein kinase) and UL54 (DNA polymerase) mutations and corresponding antiviral drug susceptibility phenotypes. It is reasonable to assume that HCMV drug resi...
Source: Antiviral Research - October 21, 2009 Category: Virology Authors: Chevillotte M, von Einem J, Meier BM, Lin FM, Kestler HA, Mertens T Tags: Antiviral Res Source Type: journals

Retrospective Diagnosis of Congenital Cytomegalovirus Infection at a School for the Deaf by Using Preserved Dried Umbilical CordEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A retrospective diagnosis of congenital cytomegalovirus infection was made for 3 of 26 students (12%) with either bilateral profound or severe sensorineural hearing loss at a School for the Deaf in Japan by detecting viral DNA with real-time polymerase chain reaction from dried umbilical cords that had been preserved at home. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 20, 2009 Category: Pediatrics Authors: Masato Tagawa, Hideo Tanaka, Masako Moriuchi, Hiroyuki Moriuchi Tags: Clinical and Laboratory Observations Source Type: journals

Detection of herpetic viruses in gingival crevicular fluid of patients suffering from periodontal diseases: prevalence and effect of treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed that the prevalence of HCMV and HSV viruses in GCF is higher in patients suffering from periodontitis compared to periodontally healthy subjects, and that the prevalence of HCMV is higher in deep periodontal pockets. It also brought evidences that periodontal therapy may be associated with virus elimination in diseased sites. PMID: 19832804 [PubMed - in process] (Source: Herpes)
Source: Herpes - October 18, 2009 Category: Infectious Diseases Authors: Grenier G, Gagnon G, Grenier D Tags: Oral Microbiol Immunol Source Type: journals

[Acute retinal necrosis from the virologist's perspective.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute retinal necrosis occurs in approximately one per million persons per year and is caused in approximately 70% of the cases by the varicella zoster virus or in about 30% of the cases by herpes simplex virus. The early diagnosis is primarily based on virus-specific polymerase chain reaction in fluid from the anterior chamber or vitreous humor and can be supported by the determination of specific antibody titers from fluid and serum. Virus detection provides the basis for early causative therapy which limits disease progression and risk of complications. Retinal infections by varicella zoster virus or herpes simplex ...
Source: Der Ophthalmologe - October 17, 2009 Category: Opthalmology Authors: Rautenberg P, Grančičova L, Hillenkamp J, Nölle B, Roider JB, Fickenscher H Tags: Ophthalmologe Source Type: journals

Schizophrenia Susceptibility Genes Directly Implicated in the Life Cycles of Pathogens: Cytomegalovirus, Influenza, Herpes simplex, Rubella, and Toxoplasma gondiiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many genes implicated in schizophrenia can be related to glutamatergic transmission and neuroplasticity, oligodendrocyte function, and other families clearly related to neurobiology and schizophrenia phenotypes. Others appear rather to be involved in the life cycles of the pathogens implicated in the disease. For example, aspartylglucosaminidase (AGA), PLA2, SIAT8B, GALNT7, or B3GAT1 metabolize chemical ligands to which the influenza virus, herpes simplex, cytomegalovirus (CMV), rubella, or Toxoplasma gondii bind. The epidermal growth factor receptor (EGR/EGFR) is used by the CMV to gain entry to cells, and a CMV gene code...
Source: Schizophrenia Bulletin - October 16, 2009 Category: Psychiatry Authors: Carter, C.J. Tags: Regular Articles Source Type: journals

CMV findings in the gastrointestinal tract in kidney transplantation patients, patients with end-stage kidney disease and immunocompetent patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion. It appears that CMV-positive cells were present in all groups studied, suggesting that CMV-infected cells alone are not sufficient to make the diagnosis of CMV disease in the transplanted host. Moreover, the clinical symptoms and the intensity of the histologic CMV findings did not correlate with the symptoms the patients were having. In kidney transplant recipients, it emerges that CMV is activated more easily in the upper rather than in the lower gastrointestinal tract. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - October 15, 2009 Category: Urology & Nephrology Authors: Lempinen, M., Halme, L., Sarkio, S., Arola, J., Honkanen, E., Turunen, U., Salmela, K., Lautenschlager, I. Tags: Transplantation Source Type: journals