Dengue Fever
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Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model
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New research challenges the dogma of the antibody-dependent enhancement model for the development of dengue hemorrhagic fever. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 20, 2009 Category: Science Source Type: news
Effects of the El Nino-Southern Oscillation on dengue epidemics in Thailand, 1996-2005Email this article to a colleague.
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Conclusions:
El Nino is one of the important driving forces for dengue epidemics across the geographically diverse regions of Thailand; however, spatial heterogeneity in the effect exists. The effects of El Nino should be taken into account in future epidemic forecasting for public health preparedness. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - November 20, 2009 Category: Consumer Health News Authors: Mathuros TipayamongkholgulChi-Tai FangSuratsawadee KlinchanChung-Ming LiuChwan-Chuen King Source Type: journals
Rain-hit Mexican states see dengue outbreak: officialEmail this article to a colleague.
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MEXICO CITY, Nov. 18 (Xinhua) -- The Mexican states that ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 19, 2009 Category: Consumer Health News Tags: Health Source Type: news
Clinical Review: Diagnosis and management of dengueEmail this article to a colleague.
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This article in the BMJ reviews the diagnosis and treatment of dengue and addresses the following questions:
. What causes dengue and how is it transmitted?
. What are the clinical features of dengue?
. Which haematological and biochemical abnormalities occur in dengue?
. What are the neurological manifestations in dengue?
. How to make definitive diagnosis?
. What predisposes a patient to developing dengue haemorrhagic fever?
. How to treat dengue fever?
. How might dengue be prevented?
...
Source: NeLM - Travel medicine - November 19, 2009 Category: Global & Universal Source Type: organizations
Diagnosis and management of dengueEmail this article to a colleague.
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(Source: BMJ Online First)
Source: BMJ Online First - November 18, 2009 Category: Journals (General) Authors: Teixeira, M. G., Barreto, M. L Tags: Infectious diseases, Epidemiologic studies, Immunology (including allergy), Headache (including migraine), Pain (neurology), Child health, Degenerative joint disease, Musculoskeletal syndromes CLINICAL REVIEW Source Type: journals
Dengue virus during blood donation: Pre-screen using NS1 antigenEmail this article to a colleague.
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Estimates for dengue transmission during blood donations have been upsetting in diverse geographical locations. During the 2004 dengue virus (DENV) outbreak in Cairns, Australia, the risk of collecting a viremic donation could have been as high as 1 in 1028 during the peak of the outbreak . Using a mathematical model and assuming a ratio of asymptomatic to symptomatic infections of 2:1–10:1, the risk for dengue-infected blood transfusions in Singapore, a city-state in Asia, during 2005 was estimated to be 1625–6/10,000 blood transfusions . In a tertiary care teaching hospital that provides care in Northeast Mexico, 800...
Source: Transfusion and Apheresis Science - November 18, 2009 Category: Hematology Authors: Subhash C. Arya, Nirmala Agarwal Tags: Letter to the Editor Source Type: journals
Dengue-free Cuba an example to developing countriesEmail this article to a colleague.
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Cuba has managed to stay free of dengue fever through locally-relevant research, say Maria G. Guzmán and Gustavo Kourí. (Source: SciDev.Net)
Source: SciDev.Net - November 18, 2009 Category: Global & Universal Source Type: info
Dengue fever in Cape Verde - update 1Email this article to a colleague.
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As of 16 November 2009, the Ministry of Health has reported 16 744 suspected cases of dengue in five islands: Brava, Fogo, Maio, Sal and Santiago. (Source: WHO Disease Outbreaks)
Source: WHO Disease Outbreaks - November 18, 2009 Category: Infectious Diseases Source Type: organizations
Viruses within the Flaviviridae Decrease CD4 Expression and Inhibit HIV Replication in Human CD4+ Cells.Email this article to a colleague.
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Viral infections alter host cell homeostasis and this may lead to immune evasion and/or interfere with the replication of other microbes in coinfected hosts. Two flaviviruses are associated with a reduction in HIV replication or improved survival in HIV-infected people (dengue virus (DV) and GB virus type C (GBV-C)). GBV-C infection and expression of the GBV-C nonstructural protein 5A (NS5A) and the DV NS5 protein in CD4(+) T cells inhibit HIV replication in vitro. To determine whether the inhibitory effect on HIV replication is conserved among other flaviviruses and to characterize mechanism(s) of HIV inhibition, the ...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Xiang J, McLinden JH, Rydze RA, Chang Q, Kaufman TM, Klinzman D, Stapleton JT Tags: J Immunol Source Type: journals
Distinct Antiviral Roles for Human 2',5'-Oligoadenylate Synthetase Family Members against Dengue Virus Infection.Email this article to a colleague.
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In this study, we determined the role of the human OAS/RNase L pathway in host defense against dengue virus (DEN) infection and assessed the antiviral potential of each isoform in the human OAS family. DEN replication was reduced by overexpression and enhanced by knockdown of RNase L expression, indicating a protective role for RNase L against DEN replication in human cells. The human OAS1 p42, OAS1 p46, and OAS3 p100, but not the other OAS isoforms, blocked DEN replication via an RNase L-dependent mechanism. Furthermore, the anti-DEN activities of these three OAS isoforms correlated with their ability to trigger RNase L a...
Source: Journal of Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Lin RJ, Yu HP, Chang BL, Tang WC, Liao CL, Lin YL Tags: J Immunol Source Type: journals
Multiyear Climate Variability and Dengue—El Niño Southern Oscillation, Weather, and Dengue Incidence in Puerto Rico, Mexico, and Thailand: A Longitudinal Data AnalysisEmail this article to a colleague.
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Michael Johansson and colleagues use wavelet analysis to show that there is limited evidence for a multiyear relationship between climate and dengue incidence in Puerto Rico, Mexico, and Thailand. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: Michael A. Johansson et al. Source Type: journals
The Link between Dengue Incidence and El Niño Southern OscillationEmail this article to a colleague.
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Pejman Rohani discusses a new study that examined the dynamic relationship between climate variables and dengue incidence in Thailand, Mexico, and Puerto Rico. (Source: PLoS Medicine)
Source: PLoS Medicine - November 17, 2009 Category: Internal Medicine Authors: Pejman Rohani Source Type: journals
Climate variability and dengue incidenceEmail this article to a colleague.
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(Public Library of Science) Research published this week in PLoS Medicine demonstrates associations between local rainfall and temperature and cases of dengue fever. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2009 Category: Global & Universal Source Type: news
Dengue Virus Infections and Maternal Antibody Decay in a Prospective Birth Cohort Study of Vietnamese InfantsEmail this article to a colleague.
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The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles.
Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENV‐reactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV‐neutralizing and E protein–reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG ...
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals
Cape Verde: Emergency team responding to country’s first ever dengue fever outbreak, the biggest reported in AfricaEmail this article to a colleague.
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The Cape Verde Ministry of Health has reported 13,187 suspected cases of dengue fever in four islands within the archipelago between Oct. 1 and Nov. 9. The outbreak is the first ever reported in Cape Verde, located off the coast of Senegal, and is the biggest reported in Africa. The number of cases has increased sharply since the beginning of November, reaching 1,000 cases per day. Ninety-three cases of dengue hemorrhagic fever have been reported and six people have already died.
The international response to the dengue fever outbreak has been positive, with public health experts and international medical teams now provi...
Source: MSF News - November 13, 2009 Category: Global & Universal Tags: NEWS Source Type: organizations
Drug Companies to Fight Neglected DiseasesEmail this article to a colleague.
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By the UPI
Nov. 13, 2009
Officials at U.S. drug companies and non-profit organizations
say they plan to develop new drugs for "neglected" diseases.
The search for drugs to fight hard-to-treat diseases such as
malaria, tuberculosis and dengue fever... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 13, 2009 Category: Pharmaceuticals Source Type: news
Population Movement Can Be Critical Factor In Dengue's SpreadEmail this article to a colleague.
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Human movement is a key factor of dengue virus inflow in Rio de Janeiro, according to results from researchers in Brazil. The results, based on data from a severe epidemic in 2007-2008, contribute to new understanding on the dynamics of dengue fever in the second largest city in Brazil. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 13, 2009 Category: Science Source Type: news
[Comment] Dengue in Cuba: research strategy to support dengue controlEmail this article to a colleague.
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In recognition of the importance of research for human health, Cuba has been working hard to improve its capacity to face infectious diseases. Among these, dengue, an arthropod-borne disease caused by dengue viruses and transmitted by the Aedes aegypti mosquito, occupies a major position, when we consider that Cuba is surrounded by endemic countries and thus at risk of virus introduction. (Source: LANCET)
Source: LANCET - November 13, 2009 Category: Journals (General) Authors: Maria G Guzmán, Gustavo Kourí Tags: Comment Source Type: journals
Optimization of Assay Conditions fo r Dengue Virus Protease: Effect of Various Polyols and Nonionic DetergentsEmail this article to a colleague.
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The aim of this work was to perform a systematic study of the effect of nonionic detergents on the activity of the dengue virus NS2B-NS3 protease. To ensure a high activity of the protease, the assay procedures for the dengue virus and other flaviviral proteases published to date are performed in the presence of up to 35% glycerol, which does not represent the cellular physicochemical environment. In addition, the high viscosity of glycerol-containing solutions leads to various experimental problems in miniaturized assays. Using an internally quenched peptide substrate, the authors show that glycerol is not essential for e...
Source: Journal of Biomolecular Screening - November 12, 2009 Category: Molecular Biology Authors: Steuer, C., Heinonen, K. H., Kattner, L., Klein, C. D. Tags: Articles Source Type: journals
Genetics vs. bug-borne illnessEmail this article to a colleague.
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Arizona Daily Star - Genetically engineered mosquitoes created by UA entomologists could provide a valuable weapon against malaria, dengue, West Nile and West Nile and other mosquito-transmitted diseases. http://www.azstarnet.com/metro/317273 (Source: West Nile)
Source: West Nile - November 12, 2009 Category: American Health Source Type: organizations
Weekly Worldwide Wrap-UpEmail this article to a colleague.
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Welcome to the Weekly Worldwide Wrap-Up, in which we consolidate the international Red Cross and Red Crescent news into one list of bite-sized links for you. It’s a non-comprehensive sampling of the larger and/or more intriguing aspects of our global work…
[The place names link to maps so that you can get a quick idea of the region.]
SOMALIA: Heavy rains are severely affecting thousands of families displaced by the hostilities in Mogadishu. The ICRC has distributed 7,000 tarpaulins as emergency shelter.
PAKISTAN: The ICRC and the Pakistan Red Crescent Society have launched the first stage of an extensive...
Source: Red Cross Chat - November 12, 2009 Category: Global & Universal Authors: Robin Parker Tags: International Source Type: organizations
Uniting To Fight The World's Neglected DiseasesEmail this article to a colleague.
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Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. Those hard-to-treat diseases include malaria, tuberculosis, dengue fever, and other conditions. That's the topic of the cover story scheduled for the current issue of Chemical & Engineering News, ACS' weekly newsmagazine. (Source: Tropical Diseases News From Medical News Today)
Source: Tropical Diseases News From Medical News Today - November 12, 2009 Category: Tropical Medicine Tags: Tropical Diseases Source Type: news
Uniting To Fight The World's Neglected DiseasesEmail this article to a colleague.
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Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. Those hard-to-treat diseases include malaria, tuberculosis, dengue fever, and other conditions. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 12, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
Dominican Republic reduces dengue infectionsEmail this article to a colleague.
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HAVANA, Nov. 11 (Xinhua) -- Health authorities from the ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 12, 2009 Category: Consumer Health News Tags: Health Source Type: news
Protection against dengue virus by non-replicating and live attenuated vaccines used together in a prime boost vaccination strategy.Email this article to a colleague.
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A new vaccination strategy for dengue virus (DENV) was evaluated in rhesus macaques by priming with tetravalent purified inactivated virus (TPIV) or tetravalent plasmid DNA vaccines expressing the structural prME gene region (TDNA) then boosting 2 months later with a tetravalent live attenuated virus (TLAV) vaccine. Both vaccine combinations elicited virus neutralizing (N) antibodies. The TPIV/TLAV combination afforded complete protection against DENV 3 challenge at month 8. In a second experiment, priming with TPIV elicited N antibodies against all four serotypes (GMT 1:28 to 1:43). Boosting with TLAV led to an increa...
Source: Virology - November 12, 2009 Category: Virology Authors: Simmons M, Burgess T, Lynch J, Putnak R Tags: Virology Source Type: journals
Cape Verde: Biggest recorded dengue fever outbreak in AfricaEmail this article to a colleague.
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The Cape Verde Ministry of Health has reported 13,187 suspected cases of dengue fever in four islands within the archipelago between 1st October and 9th November. (Source: MSF News)
Source: MSF News - November 11, 2009 Category: Global & Universal Source Type: organizations
Also In Global Health: Child Sexual Abuse In Zimbabwe; Dengue Outbreak In Cape Verde; Program Reduces Waste In Kenya SlumsEmail this article to a colleague.
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Mail & Guardian Examines Sexual Abuse Of Children In Zimbabwe The Mail & Guardian examines how the "economic collapse" in Zimbabwe has contributed to rising numbers of children falling victims to sexual abuse. (Source: Sexual Health / STDs News From Medical News Today)
Source: Sexual Health / STDs News From Medical News Today - November 11, 2009 Category: Sexual Medicine Tags: Pediatrics / Children's Health Source Type: news
Also In Global Health: Child Sexual Abuse In Zimbabwe; Dengue Outbreak In Cape Verde; Program Reduces Waste In Kenya SlumsEmail this article to a colleague.
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Mail & Guardian Examines Sexual Abuse Of Children In Zimbabwe The Mail & Guardian examines how the "economic collapse" in Zimbabwe has contributed to rising numbers of children falling victims to sexual abuse. "A single clinic in the capital, Harare, says it has treated nearly 30,000 girls and boys who were abused in the past four years - an average of 20 per day. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 11, 2009 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news
10 cases of dengue fever detected in SenegalEmail this article to a colleague.
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DAKAR, Nov. 11 (Xinhua) -- Up to 10 cases of dengue fever, ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 11, 2009 Category: Consumer Health News Tags: Health Source Type: news
Drug industry, nonprofits join forces to fight world's neglected diseasesEmail this article to a colleague.
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(American Chemical Society) Drug companies and nonprofit organizations are joining forces to develop new drugs and vaccines to target so-called "neglected" diseases that claim millions of lives in the developing world each year. Those hard-to-treat diseases include malaria, tuberculosis, dengue fever and other conditions. That's the topic of the cover story scheduled for the current issue of Chemical & Engineering News, ACS' weekly newsmagazine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 11, 2009 Category: Global & Universal Source Type: news
The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion.Email this article to a colleague.
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The flaviviral envelope (E) protein directs virus-mediated membrane fusion. To investigate membrane fusion as a requirement for virus growth, we introduced 27 unique mutations into the fusion peptide of an infectious cDNA clone of dengue 2 virus and recovered seven stable mutant viruses. The fusion efficiency of the mutants was impaired, demonstrating for the first time the requirement for specific FP AAs in optimal fusion. Mutant viruses exhibited different growth kinetics and/or genetic stabilities in different cell types and adult mosquitoes. Virus particles could be recovered following RNA transfection of cells wit...
Source: Virology - November 11, 2009 Category: Virology Authors: Huang CY, Butrapet S, Moss KJ, Childers T, Erb SM, Calvert AE, Silengo SJ, Kinney RM, Blair CD, Roehrig JT Tags: Virology Source Type: journals
Population Movement Can Be Critical Factor In Dengue's SpreadEmail this article to a colleague.
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Human movement is a key factor of dengue virus inflow in Rio de Janeiro, according to results from researchers based at the Oswaldo Cruz Foundation (Fiocruz) in Brazil. The results, based on data from a severe epidemic in 2007-2008, contribute to new understanding on the dynamics of dengue fever in the second largest city in Brazil. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 10, 2009 Category: Consumer Health News Tags: Tropical Diseases Source Type: news
Population Movement Can Be Critical Factor In Dengue's SpreadEmail this article to a colleague.
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Human movement is a key factor of dengue virus inflow in Rio de Janeiro, according to results from researchers based at the Oswaldo Cruz Foundation (Fiocruz) in Brazil. The results, based on data from a severe epidemic in 2007-2008, contribute to new understanding on the dynamics of dengue fever in the second largest city in Brazil. Details are published November 10 in the open-access journal PLoS Neglected Tropical Diseases. (Source: Tropical Diseases News From Medical News Today)
Source: Tropical Diseases News From Medical News Today - November 10, 2009 Category: Tropical Medicine Tags: Tropical Diseases Source Type: news
Genic Incompatibilities in Two Hybrid BacteriophagesEmail this article to a colleague.
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Horizontal gene transfer and recombination play a major role in microbial evolution and have been detected in diverse groups, including many of medical relevance such as HIV and dengue virus. In the absence of mechanistic barriers, the evolutionary success of a particular recombination event is determined by whether the recombinant genotype suffers a fitness cost through the disruption of favorable epistatic interactions within the genome, and if so, the extent to which this fitness cost might be mitigated by subsequent compensatory evolution. To investigate the importance of epistatic interactions between genes and the ev...
Source: Molecular Biology and Evolution - November 10, 2009 Category: Molecular Biology Authors: Rokyta, D. R., Wichman, H. A. Tags: Research Articles Source Type: journals
Global spread of epidemic dengue: the influence of environmental changeEmail this article to a colleague.
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Future Virology , November 2009, Vol. 4, No. 6, Pages 571-580. (Source: Future Virology)
Source: Future Virology - November 9, 2009 Category: Virology Tags: article Source Type: journals
Dengue virus markers of virulence and pathogenicityEmail this article to a colleague.
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Future Virology , November 2009, Vol. 4, No. 6, Pages 581-589. (Source: Future Virology)
Source: Future Virology - November 9, 2009 Category: Virology Tags: article Source Type: journals
Two-Dimensional Difference Gel Electrophoresis (DiGE) Analysis of Plasmas from Dengue Fever PatientsEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - November 9, 2009 Category: Biochemistry Tags: article Source Type: journals
Population movement can be critical factor in dengue's spreadEmail this article to a colleague.
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(Public Library of Science) Human movement is a key factor of dengue virus inflow in Rio de Janeiro, according to results from researchers based at the Oswaldo Cruz Foundation in Brazil. The results, based on data from a severe epidemic in 2007-2008, contribute to new understanding on the dynamics of dengue fever in the second largest city in Brazil. Details are published November 10 in the open-access journal PLoS Neglected Tropical Diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 9, 2009 Category: Global & Universal Source Type: news
Dengue fever, Cape Verde.Email this article to a colleague.
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Authors:
PMID: 19899226 [PubMed - in process] (Source: Weekly Epidemiological Record)
Source: Weekly Epidemiological Record - November 9, 2009 Category: Epidemiology Tags: Wkly Epidemiol Rec Source Type: journals
Science and technology to combat dengue virus.Email this article to a colleague.
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PMID: 19893888 [PubMed - in process] (Source: An Acad Bras Cienc)
Source: An Acad Bras Cienc - November 8, 2009 Category: Science Authors: Silva JL, Oliveira AC Tags: An Acad Bras Cienc Source Type: journals
An entomological surveillance system based on open spatial information for participative dengue control.Email this article to a colleague.
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We describe here the SMCP-Aedes - Monitoring System and Population Control of Aedes aegypti, aiming to provide an entomological surveillance framework as a basis for epidemiological surveillance of dengue. The SMCP-Aedes is uphold in the space technology information, supported by the intensive use of the web and free software to collect, store, analyze and disseminate information on the spatial-temporal distribution of the estimated density for the population of Aedes, based on data systematically collected with the use of ovitraps. Planned control interventions, intensified where and when indicated by the entomological su...
Source: An Acad Bras Cienc - November 8, 2009 Category: Science Authors: Regis L, Souza WV, Furtado AF, Fonseca CD, Silveira JC, Ribeiro PJ, Melo-Santos MA, Carvalho MS, Monteiro AM Tags: An Acad Bras Cienc Source Type: journals
Membrane and envelope virus proteins co-expressed as lysosome associated membrane protein (LAMP) fused antigens: a potential tool to develop DNA vaccines against flaviviruses.Email this article to a colleague.
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Vaccination is the most practical and cost-effective strategy to prevent the majority of the flavivirus infection to which there is an available vaccine. However, vaccines based on attenuated virus can potentially promote collateral side effects and even rare fatal reactions. Given this scenario, the development of alternative vaccination strategies such as DNA-based vaccines encoding specific flavivirus sequences are being considered. Endogenous cytoplasmic antigens, characteristically plasmid DNA-vaccine encoded, are mainly presented to the immune system through Major Histocompatibility Complex class I - MHC I molecu...
Source: An Acad Bras Cienc - November 8, 2009 Category: Science Authors: Dhalia R, Maciel M, Cruz FS, Viana IF, Palma ML, August T, Marques ET Tags: An Acad Bras Cienc Source Type: journals
Early molecular markers predictive of dengue hemorrhagic fever.Email this article to a colleague.
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This study evaluates the predictive potential of specific mRNA expression markers of dengue hemorrhagic fever using quantitative real-time PCR assays. Six candidate 'dengue hemorrhagic fever specific signature genes' were evaluated and all showed good correlation among their transcription levels at early days of infection and the later development of severe vasculopathy. The markers selected were able to indicate, at early stages of infection, the evolution of a dengue-infected patient to the severe form of the illness. Despite the fact that these results grant further validation studies, the panel of candidate prognostic ...
Source: An Acad Bras Cienc - November 8, 2009 Category: Science Authors: Calzavara-Silva CE, Gomes AL, Maia RC, Acioli-Santos B, Gil LH, Marques ET Tags: An Acad Bras Cienc Source Type: journals
Cape Verde: UN Agency Helps Officials in Country Tackle Outbreak of Dengue FeverEmail this article to a colleague.
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Officials from the United Nations World Health Organization (WHO) are at work in the Atlantic Ocean archipelago of Cape Verde to help local authorities battle the country's first reported epidemic of dengue fever. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 6, 2009 Category: African Health Source Type: news
N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA PolymeraseEmail this article to a colleague.
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Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 6, 2009 Category: Chemistry Tags: article Source Type: journals
Also In Global Health News: Kenya Child Mortality; DRC Rape; Cape Verde Dengue Outbreak; Guatemala Malnutrition; East Africa FloodingEmail this article to a colleague.
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Child Mortality In Kenya Still High, Survey Shows "The most current data from the Kenya National Bureau of Statistics under the Demographic and Health Survey (DHS) launched on Wednesday shows mortality among children under five years stands at 7.4 percent, while that of infants is at 5.2 percent," Business Daily reports. (Source: Nutrition/Agriculture News From Medical News Today)
Source: Nutrition/Agriculture News From Medical News Today - November 6, 2009 Category: Nutrition Tags: Pediatrics / Children's Health Source Type: news
Also In Global Health News: Kenya Child Mortality; DRC Rape; Cape Verde Dengue Outbreak; Guatemala Malnutrition; East Africa FloodingEmail this article to a colleague.
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Child Mortality In Kenya Still High, Survey Shows "The most current data from the Kenya National Bureau of Statistics under the Demographic and Health Survey (DHS) launched on Wednesday shows mortality among children under five years stands at 7.4 percent, while that of infants is at 5.2 percent," Business Daily reports. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2009 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news
UN agency helps officials in Cape Verde tackle outbreak of dengue feverEmail this article to a colleague.
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Officials from the United Nations World Health Organization (WHO) are at work in the Atlantic Ocean archipelago of Cape Verde to help local authorities battle the country's first reported epidemic of dengue fever. (Source: UN News Centre - Health, Poverty, Food Security)
Source: UN News Centre - Health, Poverty, Food Security - November 6, 2009 Category: Global & Universal Source Type: organizations
Dominican Republic intensifies campaign against dengueEmail this article to a colleague.
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The Dominican Republic's Health Ministry announced Thursday to intensify the campaign against the dengue, which has killed 41 people in the country. (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 6, 2009 Category: Consumer Health News Tags: Health Source Type: news
JNK phosphorylation, induced during dengue virus infection, is important for viral infection and requires the presence of cholesterol.Email this article to a colleague.
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Infection with a broad diversity of viruses often activates host cell signaling pathways including the mitogen-activated protein kinase pathway. The present study established that dengue virus infection of human macrophages activates Jun NH(2)-terminal kinase (JNK) and the p38 MAPKs pathways. The activation was observed at early times after infection and occurs when either infectious or UV-inactivated dengue virus was used. The role of these activated kinases in dengue virus infection was evaluated using specific inhibitors. Inhibition of JNK and p38 kinases did result in a significant reduction in viral protein synthe...
Source: Virology - November 6, 2009 Category: Virology Authors: Ceballos-Olvera I, Chávez-Salinas S, Medina F, Ludert JE, Del Angel RM Tags: Virology Source Type: journals
