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This page shows you the latest news and research items in this category.
Effectiveness of topical maxacalcitol for acquired perforating disorder
We report the case of a 69-year-old Japanese woman with numerous pruritic eruptions on her trunk, arms, and legs that had existed for 5 months. She had had diabetes mellitus for 20 years and had received hemodialysis for renal failure 2 months prior to her presentation. On examination, multiple erythematous and umbilicated papules with a central keratotic plug, 3 to 5 mm in diameter, were scattered on the trunk and extremities (, A). Histopathologic examination revealed crusts containing keratin, neutrophil debris, and degenerated basophilic collagen fibers in the center of the acanthotic epidermis, an appearance consisten...
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Hiroyuki Yoshiya, Ryuhei Okuyama, Hisashi Uhara Tags: JAAD Online Source Type: research
Tumor necrosis factor inhibition and glucose homeostasis
We report the development of hyperglycemia related to adalimumab therapy in a patient with psoriasis. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Ammon J. Larsen, Jennie T. Clarke Tags: JAAD Online Source Type: research
The role of insulin-like growth factor I and hypoxia inducible factor 1α in vascular endothelial growth factor expression in type 2 diabetes.
CONCLUSIONS: Our data demonstrate that HIF-1α and IL-6 could regulate VEGF expression, and that higher levels of HIF-1α, IL-6, and VEGF may contribute to the pathogenesis of diabetic micro-angiopathy. PMID: 23462604 [PubMed - in process] (Source: Annals of Clinical and Laboratory Science)
Source: Annals of Clinical and Laboratory Science - May 23, 2013 Category: Laboratory Medicine Authors: Jiang F, Tang YT, Guo L, Jiao XY Tags: Ann Clin Lab Sci Source Type: research
Statin diabetes link
New research shows certain statins may increase diabetes risk among older people (Source: BHF National News)
Source: BHF National News - May 23, 2013 Category: Cardiology Source Type: news
Two studies address diabetes risks with statins—one good news, one so-so
While one study is reassuring for older patients treated with statins, with researchers finding no evidence of an increased risk of diabetes in acute coronary syndrome patients, the other suggests that the more potent statins, such as rosuvastatin, atorvastatin, and simvastatin, do pose an increased risk compared with pravastatin. (Source: theHeart.org)
Source: theHeart.org - May 23, 2013 Category: Cardiology Source Type: news
GRADE Trial to Compare Top Diabetes Drugs
(MedPage Today) -- Researchers are launching a large-scale comparative effectiveness trial that will help determine which of the top type 2 diabetes drugs are best for glycemic control. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - May 23, 2013 Category: Cardiology Source Type: news
FDA Approves AIC Test to Diagnose DiabetesFDA Approves AIC Test to Diagnose Diabetes
FDA Approvals (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news
Marijuana: The next diabetes drug?
Toking up may help marijuana users to stay slim and lower their risk of developing diabetes, according to the latest study, which suggests that cannabis compounds may help in controlling blood sugar. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2013 Category: Consumer Health News Source Type: news
Marijuana tied to better blood sugar control
NEW YORK (Reuters Health) - People who had used marijuana in the past month had smaller waists and lower levels of insulin resistance - a diabetes precursor - than those who never tried the drug, in a new study. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news
FDA allows marketing of first A1c test labeled for diagnosing diabetes
Today the U.S. Food and Drug Administration announced that it is allowing marketing of the COBAS INTEGRA 800 Tina-quant HbA1cDx assay (Tina-quant HbA1cDx assay) for the diagnosis of diabetes by health care professionals. This is the first HbA1c test that FDA has allowed to be marketed for this use. (Source: Food and Drug Administration)
Source: Food and Drug Administration - May 23, 2013 Category: American Health Source Type: news
TODAY Study Sounds Alarm Bell for Youth with Type 2 DiabetesTODAY Study Sounds Alarm Bell for Youth with Type 2 Diabetes
Youths with an aggressive form of type 2 diabetes may have complications such as kidney and cardiovascular disease as early as their 20s and 30s, new data from the TODAY study suggest. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Fish body oil may reduce risk of type 2 diabetes
BOSTON, May 23 (UPI) -- Fish body oil supplements modestly increase amounts of a hormone associated with lower risk of type 2 diabetes and heart disease, U.S. researchers say. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 23, 2013 Category: Consumer Health News Source Type: news
Diabetes Drug Shows Promise in Parkinson'sDiabetes Drug Shows Promise in Parkinson's
Results of small proof-of-concept trial should spur further interest in funding a larger controlled trial of exenatide in patients with PD. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
A National Web Conference on Using Health IT To Improve Outcomes in Vulnerable and Disadvantaged Populations
Date: June 3, 2013 Time: 10:30a.m-12:00 p.m., PST Overall Purpose: The Agency for Healthcare Research and Quality (AHRQ) has identified a gap in health care and public health practitioners’ knowledge of health IT using multiple mechanisms, including the findings of the continuing education (CE) planning group. This series of Webinars is designed to increase practitioners’ ability to improve health care decisionmaking, support patient-centered care, and improve the quality and safety of care through the use of health IT. Health IT can enhance self-management and quality of life for patients within traditionally vulnera...
Source: Dragonfly - May 23, 2013 Category: Databases & Libraries Authors: Mahria Lebow Tags: Public Health Technology Source Type: news
High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C.
Abstract Hepatitis C virus (HCV) is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC) worldwide. The risk for the development of HCC increases with the severity of liver inflammation and fibrosis. The hepatic inflammation caused by HCV involves host regulatory immune response, which is mediated by cytokines with anti-viral role upon the interaction of viral polypeptides with innate and adaptive immunity. Two cytokines; tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) play key roles in the regulation of cellular immune response in HCV infection. The aim of the present ...
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Aroucha DC, do Carmo RF, Moura P, Silva JL, Vasconcelos LR, Cavalcanti MS, Muniz MT, Aroucha ML, Siqueira ER, Cahú GG, Pereira LM, Coêlho MR Tags: Cytokine Source Type: research
Self-antigen expression in thymic epithelial cells in Ifn-γ or Tnf-α deficiency.
The objective of this study was to examine the physiological role of these cytokines in vivo. For this purpose, we examined whether these cytokines have a physiological role in regulating thymic insulin expression using the Ifn-γ and Tnf-α knockout models. We found that insulin expression increased in the knockout mice compared to their wild-type counterparts. Aire transcriptional regulator, a known switch for self-antigen expression in the thymus, was also increased in the knockout animals. Four antigens targeted in other autoimmune disorders were also found to have a pattern of increase in the Ifn-γ or Tnf-α knockout...
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Levi D, Polychronakos C Tags: Cytokine Source Type: research
Erythropoietin Receptor (EpoR) Agonism Is Used to Treat a Wide Range of Disease.
Abstract The erythropoietin receptor (EpoR) was discovered and described in red blood cells (RBCs), stimulating its proliferation and survival. The target in humans for EpoR agonists drugs appears clear-to treat anemia. However, there is evidence of the pleitropic actions of erythropoietin (Epo). For that reason, rhEpo therapy was suggested as a reliable approach for treating a broad range of pathologies, including heart and cardiovascular diseases, neurodegenerative disorders (Parkinson's and Alzheimer's disease), spinal cord injury, stroke, diabetic retinopathy and rare diseases (Friedreich ataxia). Unfortunately...
Source: Molecular Medicine - May 23, 2013 Category: Molecular Biology Authors: Sanchis-Gomar F, Perez-Quilis C, Lippi G Tags: Mol Med Source Type: research
Enhancement of wound closure in diabetic mice by ex vivo expanded cord blood CD34(+) cells.
This study aimed to investigate the influence on wound closure of treatments using expanded human cord blood CD34(+) cells (CB-CD34(+) cells), freshly isolated CB-CD34(+) cells and a cytokine cocktail. The test subjects were mice with streptozotocin-induced diabetes. Wounds treated with fresh CB-CD34(+) cells showed more rapid repair than mice given the PBS control. Injection of expanded CB-CD34(+) cells improved wound closure significantly, whereas the injection of the cytokine cocktail alone did not improve wound repair. The results also demonstrated a significant decrease in epithelial gaps and advanced re-epithelializa...
Source: Cellular and Molecular Biology Letters - May 23, 2013 Category: Biochemistry Authors: Chotinantakul K, Dechsukhum C, Dejjuy D, Leeanansaksiri W Tags: Cell Mol Biol Lett Source Type: research
Total Arterial Coronary Artery Bypass Grafting in Patients with Diabetes
Introduction: Coronary artery bypass grafting using arterial conduits may improve survival and minimise harvest site complications. However, in diabetes, the outcomes of coronary artery bypass grafting performed exclusively using arterial conduits are uncertain. We reviewed our experience with this approach. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - May 23, 2013 Category: Cardiology Authors: Sean D. Galvin, William Y. Shi, John A. Fuller, Philip A. Hayward, Brian F. Buxton Tags: Abstracts Source Type: research
The Role of Closure Techniques in Sternal Dehiscence – An Artificial Model
Introduction: Sternal wound complications are a cause of significant post-operative morbidity and mortality and are generally more common in patients undergoing cardiac surgery who are elderly, have severe COPD, osteoporosis, diabetes or are undergoing bilateral mammary harvest . Many surgeons have a preferred method of sternal closure and it has been suggested that how the sternum is closed may affect the risk of dehiscence . This project was aimed at developing an artificial model of sternal dehiscence, given the difficulties of procuring cadaveric sternums and to see if there was a difference in dehiscence between the t...
Source: Heart, Lung and Circulation - May 23, 2013 Category: Cardiology Authors: Felicity Meikle, Sean Galvin, Yuanji Zhang, Kim Pickering, Adam El-Gamel Tags: Abstracts Source Type: research
High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia.
We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required. PM...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Alsultan AA, Evans BA, Elsayed EA, Al-Thawadi SI, Al-Taher AY, Amyes SG, Al-Dughaym AM, Hamouda A Tags: J Med Microbiol Source Type: research
Kocuria kristinae endocarditis related to diabetic foot infection.
We report an unusual case of endocarditis occurring in a 74-year-old man with a history of systemic hypertension, diabetes mellitus and minor amputation for left forefoot ulcer. The patient was hospitalized for vacuum-assisted closure therapy to aid in wound healing. After the first treatment session, the patient reported abdominal pain with haematemesis and fever (40 °C). Owing to persistent fever, three blood cultures were performed, all positive for Kocuria kristinae. The identification was based on biochemical tests and automated systems. The speciation of the micro-organism was achieved with MALDI-TOF and then confir...
Source: Journal of Medical Microbiology - May 23, 2013 Category: Microbiology Authors: Citro R, Prota C, Greco L, Mirra M, Masullo A, Silverio A, Bossone E, Piscione F Tags: J Med Microbiol Source Type: research
Experts Say Revamp Needed for Diabetes Drug Development Experts Say Revamp Needed for Diabetes Drug Development
Obesity drugs, too, require a new approach to approval, say doctors, because both diabetes and obesity are chronic conditions with much attendant comorbidity, which often requires lifelong therapy. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Previous contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetes.
In this study we characterized the immune response induced by Strongyloides venezuelensis infection in C57BL/6 mice and then evaluated the effect of a previous contact with this helminth in the outcome of type 1 diabetes. Animals were initially infected with 2000 L3 larvae from S. venezuelensis and euthanized 22days later. An acute phase, identified by a high amount of eggs per gram of feces, was established between days 7 and 9 post-infection. Recovery from infection was associated with a Th2 polarized response characterized by a significant level of serum IgG1 specific antibodies and also a significant production of IL-5...
Source: Experimental Parasitology - May 23, 2013 Category: Parasitology Authors: Peres RS, Chiuso-Minicucci F, da Rosa LC, Domingues A, Zorzella-Pezavento SF, França TG, Ishikawa LL, do Amarante AF, Sartori A Tags: Exp Parasitol Source Type: research
Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform.
Abstract The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary microarray platforms applying cross-verification methodology. A screening platform was established using both miRNA and genomic microarrays. Microarray analysis was then simultaneously performed on pooled atherosclerotic aortic tissues from 10 Apolipoprotein E (apoE) knockout mice (apoE-/-) and 10 healthy C57BL/6 (B6) mice. Differentiated miRNAs were screene...
Source: exp Mol Med - May 23, 2013 Category: Molecular Biology Authors: Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS Tags: Exp Mol Med Source Type: research
Aerobic Exercise Plus Resistance Training Best for DiabetesAerobic Exercise Plus Resistance Training Best for Diabetes
How does exercise improve glucose control in type 2 diabetes? A new study suggests that this beneficial effect comes from improved cardiorespiratory fitness levels and shrinking waistlines. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
Strongyloides stercoralis daf-2 encodes a divergent ortholog of Caenorhabditis elegans DAF-2.
Abstract We hypothesise that developmental arrest in infectious larvae of parasitic nematodes is regulated by signalling pathways homologous to Caenorhabditis elegans DAF (dauer formation) pathways. Alignment of Strongyloides stercoralis (Ss) DAF-2 with DAF-2 of C. elegans and homologs of other species shows that most structural motifs in these insulin-like receptors are conserved. However, the catalytic domain of Ss-DAF-2 contains two substitutions (Q1242 and Q1256), that would result in constitutive dauer formation in C. elegans or diabetes in vertebrate animals. Ss-daf-2 also shows two alternately spliced isofor...
Source: International Journal for Parasitology - May 23, 2013 Category: Parasitology Authors: Massey HC, Ranjit N, Stoltzfus JD, Lok JB Tags: Int J Parasitol Source Type: research
Deal with your chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2013 Category: Consumer Health News Source Type: news
Breastfeeding, introduction of other foods and effects on health: a systematic literature review for the 5th Nordic Nutrition Recommendations.
In conclusion, convincing and probable evidence was found for benefits of breastfeeding on several outcomes. The recommendation in NNR2004 about exclusive breastfeeding for 6 months and continued partial breastfeeding thereafter can stand unchanged. The relatively low proportion of infants in the Nordic countries following this recommendation indicates that strategies that protect, support and promote breastfeeding should be enhanced, and should also recognize the benefits for long-term health. PMID: 23589711 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - May 23, 2013 Category: Nutrition Authors: Hörnell A, Lagström H, Lande B, Thorsdottir I Tags: Food Nutr Res Source Type: research
Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults.
CONCLUSION: Our results indicate that the FTO A-allele may associate with certain food preference and in particular with certain energy-dense foods. PMID: 23589710 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - May 23, 2013 Category: Nutrition Authors: Brunkwall L, Ericson U, Hellstrand S, Gullberg B, Orho-Melander M, Sonestedt E Tags: Food Nutr Res Source Type: research
Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012.
In this study, recent guidelines and scientific background papers or updates on older reports on DF and GI published between 2000 and 2011 from the US, EU, WHO, and the World Cancer Research Fund were reviewed, as well as prospective cohort and intervention studies carried out in the Nordic countries. All of the reports support the role for fiber-rich foods and DF as an important part of a healthy diet. All of the five identified Nordic papers found protective associations between high intake of DF and health outcomes; lower risk of cardiovascular disease, type 2 diabetes, colorectal and breast cancer. None of the reports ...
Source: Food and Nutrition Research - May 23, 2013 Category: Nutrition Authors: Overby NC, Sonestedt E, Laaksonen DE, Birgisdottir BE Tags: Food Nutr Res Source Type: research
Weight loss before conception: A systematic literature review.
The objective of this study is to assess the effect of weight loss prior to conception in overweight or obese women on a number of health-related outcomes in mother and offspring using studies published between January 2000 and December 2011. Our first literature search produced 486 citations and, based on predefined eligibility criteria, 58 were selected and ordered in full text. Two group members read each paper. Fifteen studies were selected for quality assessment and two of them were considered appropriate for inclusion in evidence tables. A complementary search identified 168 citations with four papers being ordered i...
Source: Food and Nutrition Research - May 23, 2013 Category: Nutrition Authors: Forsum E, Brantsæter AL, Olafsdottir AS, Olsen SF, Thorsdottir I Tags: Food Nutr Res Source Type: research
Adiposity and hyperglycaemia in pregnancy and related health outcomes in European ethnic minorities of Asian and African origin: a review.
CONCLUSIONS: Ethnic minority women in Europe with Asian and African origin and their offspring seem to be at increased risk of T2DM and CVD, both currently and in the future. Pregnancy is an important window of opportunity for short and long-term disease prevention. PMID: 23467680 [PubMed] (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - May 23, 2013 Category: Nutrition Authors: Jenum AK, Sommer C, Sletner L, Mørkrid K, Bærug A, Mosdøl A Tags: Food Nutr Res Source Type: research
Discovering novel carriers for oral insulin tablets: a pharmacoinformatics approach.
This study is a prospect of oral insulin tablet through pharmacoinformatics approach. PMID: 23467063 [PubMed - in process] (Source: International Journal of Bioinformatics Research and Applications)
Source: International Journal of Bioinformatics Research and Applications - May 23, 2013 Category: Bioinformatics Authors: Seenivasagam R, Hemavathi K, Sivakumar G, Niranjan V Tags: Int J Bioinform Res Appl Source Type: research
Middle-preserving pancreatectomy: report of two cases and review of the literature
Conclusion: MPP is mainly beneficial for multicentric noninvasive periampullary-pancreatic lesions. However, for multicentric periampullary-pancreatic lesions involving even primary invasive cancers, as long as the invasive cancers affect only one side of the pancreas (proximal or distal), MPP could serve as a rational choice in well-selected patients. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - May 23, 2013 Category: Cancer & Oncology Authors: Kun ChengBai-yong ShenCheng-hong PengLi-ma NaDong-feng Cheng Source Type: research
A study of free radical chemistry: their role and pathophysiological significance.
Abstract Oxygen is one of the most important molecules on Earth mainly because of the biochemical symmetry of oxygenic photosynthesis and aerobic respiration that can maintain homeostasis within our planet's biosphere. Oxygen can also produce toxic molecules, reactive oxygen species (ROS). ROS play a dual role in biological systems, since they can be either harmful or beneficial to living systems. They can be considered a double-edged sword because at moderate concentrations, nitric oxide (NO•), superoxide anion, and related reactive oxygen species play an important role as regulatory mediators in signalling proc...
Source: Acta Biochim Pol - May 22, 2013 Category: Biochemistry Authors: Gutowski M, Kowalczyk S Tags: Acta Biochim Pol Source Type: research
5 ways to handle chronic pain
Chronic pain conditions now affect more than 116 million Americans, according to the Institute of Medicine, a figure that dwarfs the number of people who suffer from diabetes, coronary heart disease/stroke and cancer combined. (Source: WDSU.com - Health)
Source: WDSU.com - Health - May 22, 2013 Category: Consumer Health News Source Type: news
Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid.
This study was designed to evaluate the effects of dimerumic acid (DMA) on receptor for advanced glycation endproducts (RAGE) signal activation and THP-1 monocyte inflammation treated with S100b, a specific ligand of RAGE. We found that DMA inhibited inflammatory cytokine production via upregulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and alleviated oxidative stress through attenuation of p47phox translocation to the membrane of S100b-treated THP-1 monocytes. We found that DMA activated Nrf2 mediated by the p38 kinase pathway in THP-1 monocytes. However, anti-inflammatory activity of DMA was attenuated by...
Source: Free Radical Biology and Medicine - May 22, 2013 Category: Biology Authors: Lee BH, Hsu WH, Hsu YW, Pan TM Tags: Free Radic Biol Med Source Type: research
Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice.
Abstract Cardiac oxidative stress is an early event associated with diabetic cardiomyopathy, triggered by hyperglycemia. We tested the hypothesis that targeting left-ventricular (LV) reactive oxygen species (ROS) upregulation subsequent to hyperglycemia attenuates type 1 diabetes-induced LV remodeling and dysfunction, accompanied by attenuated proinflammatory markers and cardiomyocyte apoptosis. Male 6-week-old mice received either streptozotocin (55mg/kg/day for 5 days), to induce type 1 diabetes, or citrate buffer vehicle. After 4 weeks of hyperglycemia, the mice were allocated to coenzyme Q10 supplementation (10...
Source: Free Radical Biology and Medicine - May 22, 2013 Category: Biology Authors: Huynh K, Kiriazis H, Du XJ, Love JE, Gray SP, Jandeleit-Dahm KA, McMullen JR, Ritchie RH Tags: Free Radic Biol Med Source Type: research
Importance of insulin resistance to vascular repair and regeneration.
Abstract Metabolic insulin resistance is apparent across a spectrum of clinical disorders, including obesity and diabetes, and is characterized by an adverse clustering of cardiovascular risk factors related to abnormal cellular responses to insulin. These disorders are becoming increasingly prevalent and represent a major global public health concern because of their association with significant increases in atherosclerosis-related mortality. Endogenous repair mechanisms are thought to retard the development of vascular disease, and a growing evidence base supports the adverse impact of the insulin-resistant pheno...
Source: Free Radical Biology and Medicine - May 22, 2013 Category: Biology Authors: Cubbon RM, Mercer BN, Sengupta A, Kearney MT Tags: Free Radic Biol Med Source Type: research
Role of oxidative stress in physiological albumin glycation: A neglected interaction.
This study has for the first time demonstrated albumin glycation in vitro, using physiological concentrations of albumin, glucose, and hydrogen peroxide, identifying low-grade oxidative stress as a key element early in the glycation process. PMID: 23517782 [PubMed - in process] (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - May 22, 2013 Category: Biology Authors: Vlassopoulos A, Lean ME, Combet E Tags: Free Radic Biol Med Source Type: research
Erythrocyte caspase-3 and antioxidant defense is activated in red blood cells and plasma of type 2 diabetes patients at first clinical onset.
DISCUSSION: Increased antioxidant defense in plasma and RBCs of early type 2 diabetes patients is a potential mechanism that can overcome oxidative damage induced by reactive oxygen species overproduction, and occurs even in RBCs with a decreased life span. This observation could provide a possible explanation for the controversial effects of antioxidant supplementation in diabetes patients. PMID: 23485037 [PubMed - in process] (Source: Redox Report : communications in free radical research)
Source: Redox Report : communications in free radical research - May 22, 2013 Category: Biochemistry Authors: Savu O, Bradescu OM, Serafinceanu C, Iosif L, Tirgoviste CI, Stoian I Tags: Redox Rep Source Type: research
Pancreatic islet cell autophagy during aging in rats.
CONCLUSION: Appearance of autophagosomes and increased Lamp2 and LC3b expression in pancreatic islet cells coincided with a significant decrease in insulin secretion and elevation of fasting blood glucose in aged rats. PMID: 23544608 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - May 22, 2013 Category: Biomedical Science Authors: Wang S, Sun QQ, Xiang B, Li XJ Tags: Clin Invest Med Source Type: research
Dismantling sociocultural barriers to eye care with tele-ophthalmology: lessons from an Alberta Cree community.
CONCLUSIONS: A culturally-sensitive model of healthcare delivery in a community-based health clinic improved access to tele-ophthalmology services. This was demonstrated by increased attendance at appointments and increased satisfaction amongst patients. PMID: 23544606 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - May 22, 2013 Category: Biomedical Science Authors: Arora S, Kurji AK, Tennant MT Tags: Clin Invest Med Source Type: research
Fish Oil Pills Might Cut Diabetes Risk, Researchers Say
Higher blood levels of a beneficial hormone seen in those who took the omega-3 supplements (Source: WebMD Health)
Source: WebMD Health - May 22, 2013 Category: Consumer Health News Source Type: news
Carnosine: from exercise performance to health.
Abstract Carnosine was first discovered in skeletal muscle, where its concentration is higher than in any other tissue. This, along with an understanding of its role as an intracellular pH buffer has made it a dipeptide of interest for the athletic population with its potential to increase high-intensity exercise performance and capacity. The ability to increase muscle carnosine levels via β-alanine supplementation has spawned a new area of research into its use as an ergogenic aid. The current evidence base relating to the use of β-alanine as an ergogenic aid is reviewed here, alongside our current thoughts on t...
Source: Amino Acids - May 22, 2013 Category: Biochemistry Authors: Sale C, Artioli GG, Gualano B, Saunders B, Hobson RM, Harris RC Tags: Amino Acids Source Type: research
Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells.
In conclusion, QDPR might be an important factor mediating diabetic nephropathy through its regulation of TGF-β1/Smad3 signaling and NADPH oxidase. PMID: 23668792 [PubMed - in process] (Source: Biochemistry and Cell Biology)
Source: Biochemistry and Cell Biology - May 22, 2013 Category: Biochemistry Authors: Gu Y, Gong Y, Zhang H, Dong X, Zhao T, Burczynski FJ, Wang G, Sun S, Zhu B, Han W, Wang H, Li P Tags: Biochem Cell Biol Source Type: research
Intrauterine effects of impaired lipid homeostasis in pregnancy diseases.
Abstract Lipids are crucial structural and bioactive components that sustain embryo, fetal and placental development and growth. Intrauterine development can be disturbed by several diseases that impair maternal lipid homeostasis and lead to abnormal lipid concentrations in the fetal circulation. Deficiency in essential fatty acids can lead to congenital malformations and visual and cognitive problems in the newborn. Either deficient mother-to-fetus lipid transfer or abnormal maternal- fetal lipid metabolism can cause fetal growth restriction. On the other hand, excessive mother-to-fetus fatty acid transfer can ind...
Source: Current Medicinal Chemistry - May 22, 2013 Category: Chemistry Authors: Higa R, Jawerbaum A Tags: Curr Med Chem Source Type: research
Insulin secretion and interleukin-1β dependent mechanisms in human diabetes remission after metabolic surgery.
Abstract To compare endocrine, metabolic, and inflammatory changes induced by gastric bypass (GB) and sleeve gastrectomy (SG) in patients with type 2 diabetes mellitus (T2DM), and to investigate the mechanisms of success after metabolic surgery. Sixteen GB and 16 SG patients were followed up before and at 1 year after surgery. The 75-g oral glucose tolerance test (OGTT) was performed before and after surgery. Glucose homeostasis, serum interleukin-1β, plasma gut hormones and adipokines, and the United Kingdom Prospective Diabetes Study (UKPDS) ten-year cardiovascular risks were evaluated. The diabetes remission ra...
Source: Current Medicinal Chemistry - May 22, 2013 Category: Chemistry Authors: Chen CY, Lee WJ, Asakawa A, Fujitsuka N, Chong K, Chen SC, Lee SD, Inui A Tags: Curr Med Chem Source Type: research