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Nodular lung schistosomiais lesions after chemotherapy for dysgerminoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of pulmonary schistosomiasis in a traveler to Mali that was diagnosed 16 months after primary infection, one month after she finished chemotherapy for a malignant tumor. Serologic analysis showed marked eosinophilia. Our case emphasizes the need to detect parasitic infections in cancer patients with unexplained eosinophilia, particularly in immigrants and travelers to tropical countries. PMID: 19706907 [PubMed - in process] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - August 29, 2009 Category: Tropical Medicine Authors: de Górgolas M, Casado V, Renedo G, Alen JF, Fernández Guerrero ML Tags: Am J Trop Med Hyg Source Type: journals

Bilateral gonadoblastoma with dysgerminoma and pilocytic astrocytoma with WT1 GT-IVS9 mutation: A 46 XY phenotypic female with Frasier syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the clinical, radiological, and genetic (WT1 mutation analysis) of a 46 XY phenotypic female with Frasier syndrome with bilateral gonadoblastoma with dysgerminoma who developed pilocytic astrocytoma. Pediatr Blood Cancer © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - August 3, 2009 Category: Cancer & Oncology Authors: Vivek Subbiah, Vicki Huff, Johannes E.A. Wolff, Leena Ketonen, Frederick F. Lang Jr, John Stewart, Lauren Langford, Cynthia E. Herzog Source Type: journals

The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A role for TRC8 in dysgerminoma may relate to its interaction with Translin. We propose a model in which one copy of TRC8 is disrupted by a palindrome-mediated translocation followed by complete loss of expression through suppression, possibly mediated by miRNA. (Source: Molecular Cancer)
Source: Molecular Cancer - July 29, 2009 Category: Cancer & Oncology Authors: Stefania GimelliSilvana BeriHarry DrabkinClaudio GambiniAndrea GregorioPatrizia FiorioOrsetta ZuffardiRobert GemmillRoberto GiordaGiorgio Gimelli Source Type: journals

Commentary to “Precocious puberty in a 7-year-old boy: A novel case”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors present an unusual case of precocious puberty secondary to an unclassified type of mixed germ cell tumor. The tumor differs from a ‘classic’ MGST in that only the germ cells have a high proliferative index. More importantly, the tumor differs from classic forms in that it is the apparent cause of virilization. To date, there are no reported cases of MGST and virilization in the absence of Leydig cell hyperplasia. The authors clearly state that Leydig cell hyperplasia was absent; however they give no explanation for the elevation in testosterone. Possible clues to this problem can be found in women with gona...
Source: Journal of Pediatric Urology - June 30, 2009 Category: Urology & Nephrology Authors: Gerald Mingin Source Type: journals

SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The correct diagnosis of metastatic germ cell tumors is critical, because these tumors can be effectively treated and are even cured with modern therapy. Their histopathologic diagnosis can be challenging without immunohistochemical markers, which currently have limitations. SALL4 is a novel stem cell marker essential to maintain pluripotency and self-renewal of embryonic stem cells. In the current study, the authors investigated the utility of SALL4 as a potential diagnostic marker for metastatic germ cell tumors.Ninety metastatic germ cell tumors from testis, ovary, and extragonadal sites were stained with a monoclonal S...
Source: Cancer - April 13, 2009 Category: Cancer & Oncology Authors: Dengfeng Cao, Peter A. Humphrey, Robert W. Allan Source Type: journals

Treatment of clitoromegaly of culturally diverse patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Regardless of cultural background patients are affected by clitoromegaly. This is demonstrated in these cases by the reported feelings of discomfort, distress, and sexual inactivity due to embarrassment. The long-term significance of clitoromegaly and the value of clitoroplasty for young patients with disorders of sexual differentiation remain controversial. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - March 23, 2009 Category: Urology & Nephrology Authors: Hasan S. Merali, Patricio C. Gargollo, David A. Diamond Tags: Original Articles Source Type: journals

Surgical resection of a dysgerminoma in a mare.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal with no history of health problems. Ultrasonographic examination of the mass confirmed its presence, but the origin of the mass could not be accurately determined. Routine haematology and serum biochemistry results were within normal limits. The mare was initially treated conservatively with antibiotics, but the mass continued to increase in size, so it was surgically excised. The mass involved the left ovary. The mare showed transient abdominal pain af...
Source: Australian Veterinary Journal - March 1, 2009 Category: Veterinary Research Authors: Harland S, Smith C, Mogg T, Horadagoda N, Dart A Tags: Aust Vet J Source Type: journals

The microenvironment of germ cell tumors harbors a prominent antigen-driven humoral response.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Germ cell tumors are a heterogeneous group of neoplasms derived from residual primordial tissue. These tumors are commonly found in the brain, testes, or ovaries, where they are termed germinomas, seminomas, or dysgerminomas, respectively. Like several other tumor types, germ cell tumors often harbor an immune cell infiltrate that can include substantial numbers of B cells. Yet little is known about whether the humoral immune response affects germ cell tumor biology. To gain a deeper understanding of the role B cells play in this tumor family, we characterized the immune cell infiltrate of all three germ cell tumor sub...
Source: Journal of Immunology - February 24, 2009 Category: Allergy & Immunology Authors: Willis SN, Mallozzi SS, Rodig SJ, Cronk KM, McArdel SL, Caron T, Pinkus GS, Lovato L, Shampain KL, Anderson DE, Anderson RC, Bruce JN, O'Connor KC Tags: J Immunol Source Type: journals

A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: An 8-year-old phenotypic female with campomelic dysplasia (CD) and 46,XY sex-reversal presented with renal colic. Medullary nephrocalcinosis, urolithiasis, and renal malrotation were diagnosed by computed tomographic scanning. Pelvic sonogram identified an enlarged left gonad. Genetic testing revealed a novel SOX9 heterozygous deletion of a cytosine at nucleotide 972 (972delC), causing a frameshift at codon 200, introducing a stop codon 18 codons further downstream (P200fsX218). At laparoscopic gonadectomy, a left dysgerminoma was removed. This first reported case of dysgerminoma in a sex-reversed patient with CD...
Source: Journal of Pediatric Surgery - February 1, 2009 Category: Surgery Authors: Nicholas G. Cost, Aaron T. Ludwig, Duncan T. Wilcox, Dinesh Rakheja, Steven J. Steinberg, Linda A. Baker Tags: Independent Case Reports Source Type: journals

CT characteristics of ovarian dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Ovarian dysgerminoma has its CT characteristics. Associated with clinic data, CT is helpful in the diagnosis and differential diagnosis of ovarian dysgerminoma. Content Type Journal ArticleDOI 10.1007/s10330-008-0134-8Authors Xiaoping Yu, Hunan Provincial Tumor Hospital Department of Diagnostic Radiology Changsha 410013 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1610-1979 Journal Volume Volume 7 Journal Issue Volume 7, Number 12 / December, 2008 (Source: The Chinese-German Journal of Clinical Oncology)
Source: The Chinese-German Journal of Clinical Oncology - December 10, 2008 Category: Cancer & Oncology Tags: The Chinese-German Journal of Clinical Oncology Source Type: journals

Pulmonary cysts in early childhood and the risk of malignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Surgery for congenital and early childhood lung cysts is often dictated by symptoms such as respiratory distress, infection or pneumothorax. Asymptomatic cysts present a therapeutic dilemma: surgical intervention and "conservative" observation have advocates. The risk of malignancy in such cysts is considered by some an indication for surgical intervention and is reviewed in this paper. Pleuropulmonary blastoma (PPB) is the most frequent malignancy associated with childhood lung cysts. Although rare, PPB occurs predictably in certain clinical and familial situations. This unique biology of PPB can inform the cyst managemen...
Source: Pediatric Pulmonology - December 7, 2008 Category: Respiratory Medicine Authors: John R. Priest, Gretchen M. Williams, D. Ashley Hill, Louis P. Dehner, Adam Jaffé Source Type: journals

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One BitchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-[alpha] and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma. (Source: Reproduction in Domestic Animals)
Source: Reproduction in Domestic Animals - November 4, 2008 Category: Reproduction Medicine Authors: JK Park, MJ Goo, IH Hong, MR Ki, JY Han, KS Jeong Source Type: journals

Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Contents An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5-year-old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha-fetoprotein, inhibin-alpha and S-100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma. PMID: 18992107 [PubMed - as supplied by publisher] (Source: Reproduction in Domestic Animals)
Source: Reproduction in Domestic Animals - November 3, 2008 Category: Reproduction Medicine Authors: Park JK, Goo MJ, Hong IH, Ki MR, Han JY, Jeong KS Tags: Reprod Domest Anim Source Type: journals

Management and outcomes of ovarian masses in children and adolescents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ovarian masses in the pediatric age group are rare, and malignancies are even less common. We reviewed our large single-center experience to determine the rate of malignancy and discuss management. We retrospectively reviewed the cases of ovarian masses in children in our institution over a 10-year period. Demographic and tumor-specific data were reviewed and analyzed, and a Student's unpaired t test was used where appropriate. A total of 49 children and adolescents with ovarian masses were found. The mean age at presentation was 13.3 years. Eight masses were malignant (16%) with malignant teratoma, dysgerminoma, and g...
Source: The American Surgeon - November 1, 2008 Category: Surgery Authors: Islam S, Yamout SZ, Gosche JR Tags: Am Surg Source Type: journals

[Cerebral venous thrombosis in a chemotherapy patient with dysgerminoma.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19128751 [PubMed - in process] (Source: Anales de Pediatria)
Source: Anales de Pediatria - November 1, 2008 Category: Pediatrics Authors: Latorre González G, López de Silanes de Miguel C, Escribano Gascón AB Tags: An Pediatr (Barc) Source Type: journals

First Report of Ovarian Dysgerminoma in Cowden Syndrome with Germline PTEN Mutation and PTEN-related 10q Loss of Tumor Heterozygosity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 1258DOI: 10.1097/PAS.0b013e31816be8b7Authors: Cho, Mee-Yon MD, PhD *; Kim, Hyun Soo MD, PhD +; Eng, Charis MD, PhD ++; Kim, Dae Sung MD, PhD [S]; Kang, Seong Joon MD, PhD [S]; Eom, Minseob MD *; Yi, Sang Yeop MD, PhD [//]; Bronner, Mary P. MD [P] (Source: The American Journal of Surgical Pathology)
Source: The American Journal of Surgical Pathology - July 26, 2008 Category: Pathology Tags: Abstract HTML PDF (823 K) Source Type: journals

The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Prevalence of lymph node metastasis varies according to histology in OGCT and is an independent predictor of poor survival in these patients. These findings highlight the value of lymphadenectomy and may be helpful in creating risk stratification models for individualization of adjuvant therapies. PMID: 18571705 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - June 19, 2008 Category: Cancer & Oncology Authors: Kumar S, Shah JP, Bryant CS, Imudia AN, Cote ML, Ali-Fehmi R, Malone JM, Morris RT Tags: Gynecol Oncol Source Type: journals

The influence of conservative surgical practices for malignant ovarian germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate demographics, survival, and surgical trends for patients with malignant ovarian germ cell tumors.SEER data abstracted from 1988 to 2001 and analyzed using Kaplan-Meier and Cox regression models.Of 760 patients, the median age was 23 years. Seventy-six percent of patients presented with stage I-II disease, and 24% with stage III-IV. Fifty-five percent were immature teratomas, 32% dysgerminomas, and 13% yolk sac tumors. Fertility-preserving surgery was performed in 41.2% (n = 313) of patients. In those (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - June 18, 2008 Category: Cancer & Oncology Authors: John K. Chan, Krishnansu S. Tewari, Sarah Waller, Michael K. Cheung, Jacob Y. Shin, Kathryn Osann, Daniel S. Kapp Source Type: journals

Fluorescence in situ hybridization of 12p in germ cell tumors using a bacterial artificial chromosome clone 12p probe on paraffin-embedded tissue: clinical test validation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe an interphase FISH assay for detection of increased 12p copy number in germ cell tumors using a bacterial artificial chromosome-derived probe localized to 12p12.1 and a commercially available probe for the centromere of chromosome 12. Twenty-four paraffin-embedded blocks from 14 tumor cases (7 malignant mixed germ cell tumors, 2 dysgerminomas, 4 non-germ cell malignancies arising in germ cell tumors, and 1 mediastinal adenocarcinoma) and 18 normal controls were studied. Negative controls included normal lymph node, lung, and mediastinal tissue. The signals for 12p and 12cen were counted, and the ratio of the av...
Source: Cancer Genetics and Cytogenetics - May 28, 2008 Category: Stem Cells Authors: Wehle D, Yonescu R, Long PP, Gala N, Epstein J, Griffin CA Tags: Cancer Genet Cytogenet Source Type: journals

Germ cell tumors of the ovary.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: MOGCTs are rare neoplasms that affect girls and young women and have excellent prognosis at all stages of disease with optimal therapy. The majority of MOGCTs patients retain their reproductive function. PMID: 18378402 [PubMed - as supplied by publisher] (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - March 29, 2008 Category: Cancer & Oncology Authors: Pectasides D, Pectasides E, Kassanos D Tags: Cancer Treat Rev Source Type: journals

Influence of Tumor Site and Histology on Long-Term Survival in 193 Children with Extracranial Germ Cell TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Eur J Pediatr Surg 2008; 18: 1-6DOI: 10.1055/s-2007-989399Abstract Although germ cell tumors (GCT) supposedly share the same cell type of origin, their clinical course differs considerably depending on tumor site and histology. The aim of this work was to study long-term survival stratified for tumor site and tumor histology. The medical records of 193 consecutive infants and children with extracranial GCT were studied. The GCT arose in the following anatomical sites: sacrococcygeal (n = 70), ovary (n = 66), testis (n = 20), retroperitoneum (n = 12), neck (n = 8), mediastinum (n = 7), and miscellaneous (n = 10). Histologic...
Source: European Journal of Pediatric Surgery - February 27, 2008 Category: Surgery Tags: Original Article Source Type: journals

Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gonadoblastoma (GB) is an in situ tumor consisting of a heterogeneous population of mature and immature germ cells, other cells resembling immature Sertoli/granulosa cells, and Leydig/lutein-like cells, may also be present. GB almost exclusively affects a subset of patients with intersex disorders and in 30% of them overgrowth of the germinal component of the tumor is observed and the lesion is term dysgerminoma/seminoma. Several pathways have been proposed to explain the malignant process, and abnormal OCT3/4 expression is the most robust risk factor for malignant transformation. Some authors have suggested that OCT3/...
Source: Cancer Letters - February 21, 2008 Category: Cancer & Oncology Authors: Palma I, Peña RY, Contreras A, Ceballos-Reyes G, Coyote N, Eraña L, Kofman-Alfaro S, Queipo G Tags: Cancer Lett Source Type: journals

[Swyer syndrome: A five-cases report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The risk of gonadal neoplasia is high, dictating early prophylactic removal of these dysgenesic gonads. PMID: 18242875 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction)
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - January 31, 2008 Category: OBGYN Authors: Ben Temime R, Chechia A, Attia L, Ghodbane I, Boudaya F, Makhlouf T, Koubaa A Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: journals

Clinical analysis of 57 patients with ovarian dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The prognosis of ovarian dysgerminoma is closely related to the disease stage and treatment modality. A fertility-preserving operation can be considered in early -staged patients, but caution needs to be exercised in the middle to late staged cases. Good results can be achieved with an operation-based combined modality in recurrent patients. Content Type Journal ArticleCategory Original ArticlesDOI 10.1007/BF02782179Authors Yanfang Li, Sun Yat-sen University Department of Gynecologic Oncology, Cancer Center 510060 Guangzhou ChinaMenda LP, Sun Yat-sen University Department of Gynecologic On...
Source: Chinese Journal of Clinical Oncology - January 3, 2008 Category: Cancer & Oncology Tags: Chinese Journal of Clinical Oncology Source Type: journals

Y chromosomal sequences identified in gonadal tissue of two 45,X patients with turner syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined excised gonadal tissue obtained from two 45,X patients for evidence of Y chromosomal material. Both patients had features atypical for individuals with Turner syndrome, a large dysgerminoma in patient 1 and clitoromegaly in patient 2. Southern blot analysis of polymerase chain reaction (PCR)-amplified DNA was performed for five Y chromosome-specific probes (SRY, ZFY, DYZ3, KALY, and DYZ1). Fluorescencein situ hybridization (FISH) with a combination probe specific for the DYZ1/DYZ3 loci was utilized. For both patients, Southern blot analysis of PCR-amplified DNA with primers for the SRY gene was positive. No...
Source: Endocrine Pathology - November 8, 2007 Category: Pathology Tags: Endocrine Pathology Source Type: journals

Müllerian inhibiting substance type II receptor (MISIIR): A novel, tissue-specific target expressed by gynecologic cancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS.: In the largest study to date, we report that MISIIR is highly expressed by a wide variety of gynecologic cancers, including cancers currently without effective systemic therapies. Low levels of expression in select non-gynecologic tissues coupled with high expression in gynecologic malignancies make MISIIR an attractive target for novel therapeutics and tumor-directed imaging in the management of gynecologic cancers. Further investigation into the impact of MISIIR expression and OS is also warranted. PMID: 17988723 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 5, 2007 Category: Cancer & Oncology Authors: Bakkum-Gamez JN, Aletti G, Lewis KA, Keeney GL, Thomas BM, Navarro-Teulon I, Cliby WA Tags: Gynecol Oncol Source Type: journals

High-throughput microRNAome analysis in human germ cell tumoursEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We reported previously that the miRNAs hsa-miR 371-373 cluster is involved in overruling cellular senescence induced by oncogenic stress, allowing cells to become malignant. Here we report the first high-throughput screen of 156 microRNAs in a series of type II and III GCTs (n = 69, in duplicate) using a quantitative PCR-based approach. After normalization to allow inter-sample analysis, the technical replicates clustered together, and the previous hsa-miRNA 371-373 cluster finding was confirmed. Unsupervised cluster analysis demonstrated that the cell lines are different from the in vivo samples. The in vivo samples, both...
Source: The Journal of Pathology - September 24, 2007 Category: Pathology Authors: AJM Gillis, HJ Stoop, R Hersmus, JW Oosterhuis, Y Sun, C Chen, S Guenther, J Sherlock, I Veltman, J Baeten, PJ van der Spek, P de Alarcon, LHJ Looijenga Source Type: journals

A case of dysgerminoma of the ovary with early carcinomatous featuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Histopathology Volume 0, Issue 0, Page ???-???. (Source: Histopathology)
Source: Histopathology - June 25, 2007 Category: Pathology Tags: Correspondence Source Type: journals

Dysgerminoma in three patients with Swyer syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - June 23, 2007 Category: Cancer & Oncology Authors: Nadereh Behtash and Mojgan Karimi Zarchi Source Type: journals

Could ovarian choriocarcinoma be detected by maternal serum screening for Down syndrome?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The incidence of ovarian malignancies during gestation ranges from 1 in 8000 to 1 in 20 000 deliveries. Ovarian malignancies that produce human chorionic gonadotropin (hCG) are limited to germ cell tumors, of which dysgerminoma is the most frequent (45%) malignant type encountered in pregnant patients, the others being ovarian choriocarcinoma and mixed germ cell tumors . In women of childbearing age, it is hard to distinguish between metastatic choriocarcinoma on a complete mole and primary ovarian choriocarcinoma. Treatment is based on adnexectomy followed by chemotherapy. Given the extreme rarity of these tumors, the lon...
Source: Prenatal Diagnosis - May 29, 2007 Category: Perinatology & Neonatology Authors: Anne-Sophie Gauchez, Sophie Dreux, Laetitia Stéfani, Mireille Mousseau, Pierre-Simon Jouk, Françoise Muller Source Type: journals

[Malignant ovarian germ cell tumours: a trial of 36 cases.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Surgery in a young patient with malignant ovarian germ cells tumours must be conservative (adnexectomy) (preserving fertility and because of good prognostic). In case of stage IA with part of dysgerminoma and/or immature teratoma and/or embryonal carcinoma certified by surgical staging, strict follow up could be organized (clinic, radiology, AFP, HCG). In case of more than stage IA, chemotherapy is indicated after conservative surgery and surgical staging. PMID: 17350873 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)
Source: Gynecologie, Obstetrique & Fertilite - May 1, 2007 Category: OBGYN Authors: Gueye A, Narducci F, Baranzelli MC, Collinet P, Farine O, Fournier C, Vinatier D, Leblanc E Tags: Gynecol Obstet Fertil Source Type: journals

Prognostic factors and role of salvage surgery in chemorefractory ovarian germ cell malignancies: A study in Chinese patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS.: Chemorefractory cases with dysgerminoma or immature teratoma appear to have better outcome than the other subtypes. When offered standard BEP/PVB regimen as salvage chemotherapy, patients with chemorefractory disease after non-BEP/PVB primary chemotherapy have better prognosis. Optimal cytoreduction during salvage surgery does benefit chemorefractory patients. PMID: 17459461 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 23, 2007 Category: Cancer & Oncology Authors: Li J, Yang W, Wu X Tags: Gynecol Oncol Source Type: journals

Chemotherapeutic treatment of a pregnant patient with ovarian dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion??This case report illustrates the difficulties arising from diagnosis of malignancy during pregnancy. Although combined treatment with paclitaxel and carboplatin is not considered a first-line therapy for ovarian dysgerminoma, in this case report it elicited an excellent response, and there were no adverse effects on the foetus. Content TypeJournal Article JournalArchives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - March 7, 2007 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: journals

Ovarian dysgerminomas are characterised by frequent KIT mutations and abundant expression of pluripotency markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study provides new data supporting two distinct but overlapping pathways in OGCT development; one involving spontaneous KIT mutation(s) leading to increased survival and proliferation of undifferentiated oogonia, the other related to presence of Y chromosome material and ensuing gonadal dysgenesis in phenotypic females. (Source: Molecular Cancer)
Source: Molecular Cancer - February 2, 2007 Category: Cancer & Oncology Authors: Christina E Hoei-Hansen, Sigrid M Kraggerud, Vera M Abeler, Janne Kærn, Ewa Rajpert-De Meyts and Ragnhild A Lothe Source Type: journals

Ovarian dysgerminoma and Apert syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 13-year-old female with Apert syndrome who developed an ovarian dysgerminoma. The FGFR2 exon 7 sequencing showed the classical Apert syndrome c.758C > G transversion (p.Pro253Arg). The genomic analyses of the tumor cells showed low level gains and losses of several chromosomes. This is the second report of the association of Apert syndrome with cancer. Our observation raises the hypothesis of a role for FGFR2 mutations in tumorigenesis. Pediatr Blood Cancer © 2007 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - January 22, 2007 Category: Cancer & Oncology Authors: Cécile Rouzier, Christine Soler, Paul Hofman, Caroline Brennetot, Eric Bieth, Florence Pedeutour Source Type: journals

OCT4: biological functions and clinical applications as a marker of germ cell neoplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Germ cell tumours (GCTs) are a heterogeneous group of neoplasms, which develop in the gonads as well as in extragonadal sites, that share morphological patterns and an overall good prognosis, owing to their responsiveness to current surgical, chemotherapeutic, and radiotherapeutic measures. GCTs demonstrate extremely interesting biological features because of their close relationships with normal embryonal development as demonstrated by the pluripotentiality of some undifferentiated GCT variants. The similarities between GCTs and normal germ cell development have made it possible to identify possible pathogenetic pathways ...
Source: The Journal of Pathology - November 21, 2006 Category: Pathology Authors: L Cheng, M-T Sung, P Cossu-Rocca, TD Jones, GT MacLennan, J De Jong, A Lopez-Beltran, R Montironi, LHJ Looijenga Source Type: journals

Laparotomy for post chemotherapy residue in ovarian germ cell tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion</b> : Our study suggests that patients with absence of teratoma element initially, radiological residue of<5 cm and normalization of serum markers after two cycles of chemotherapy do not require surgery to assessthe nature of post-chemotherapy residue. However, laparotomy should be performed in patients with tumorsthat initially contain teratoma element and in those with sluggish tumor marker response after two cycles ofchemotherapy since they have a high chance of having viable postchemotherapy residue. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 15, 2006 Category: Internal Medicine Authors: Mathew GK, Singh SS, Swaminathan RG, Tenali SG Source Type: journals

Severe malignancy-associated hypercalcemia in dysgerminomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 16-year-old girl with an ovarian dysgerminoma associated with severe hypercalcemia, a metabolic abnormality infrequently reported with this disease. We review some of the potential causes of malignancy-associated hypercalcemia and current treatment strategies. It is our recommendation that calcium levels should be monitored in all children with solid ovarian masses. Hypercalcemia seen in these situations may not improve until the tumor is removed. Pediatr Blood Cancer 2006; 47:621-623. © 2005 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - September 26, 2006 Category: Cancer & Oncology Authors: Richardson Matthew, Otis Christopher, Sprinz Philippa Source Type: journals