Dysgerminoma This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Ovarian cysts and tumors in infancy and childhood
Conclusion: Pain and abdominal lump are the most common modes of presentation. Prognosis depends on the size of the tumor, stage and histology of the tumor. Conservative surgery should be the aim. Multidisciplinary management gives good prognosis. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - February 7, 2013 Category: Surgery Authors: Madhumita MukhopadhyayRam Mohan ShuklaBiswanath MukhopadhyayKartik C MandalAmit RayNeha SisodiyaMahadev Prasad Patra Source Type: research

Frasier syndrome: four new cases with unusual presentations
We report here four cases of FS diagnosis after identification of WT1 mutations. Case 1 was part of a large cohort of patients diagnosed with steroid-resistant nephrotic syndrome, in whom the screening for mutations within WT1 8-9 hotspot fragment identified the IVS9+5G>A mutation. Beside FS, this patient showed unusual characteristics, such as urinary malformation (horseshoe kidney), and bilateral dysgerminoma. Cases 2 and 3, also bearing the IVS9+5G>A mutation, and case 4, with IVS9+1G>A mutation, were studied due to FSGS and/or delayed puberty; additionally, patients 2 and 4 developed bilateral gonadal tumors. Since the...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - January 8, 2013 Category: Endocrinology Source Type: research

Ovarian dysgerminoma and synchronic contralateral tubal pregnancy followed by normal intra-uterine gestation: a case report
Conclusions: Our report on the challenges of diagnosis and treatment faced in this case can help clinicians better understand and manage these pathologies. We have not found any similar cases in the literature. (Source: BioMed Central)
Source: BioMed Central - November 23, 2012 Category: Journals (General) Authors: Lourdes MontesinosPedro AciénMonserrat Martínez-BeltránMaría-José Mayol Source Type: research

A Practical Approach to Immunohistochemical Diagnosis of Ovarian Germ Cell Tumors and Sex Cord‐Stromal Tumors
Abstract Immunohistochemistry can be useful in the diagnosis of ovarian germ cell tumors and sex cord‐stromal tumors. A wide variety of markers are available, including many that are novel. The aim of this review is to provide a practical approach to selection and interpretation of these markers, emphasizing an understanding of their sensitivity and specificity in the particular differential diagnosis in question. The main markers discussed include those for malignant germ cell differentiation (SALL4, PLAP), dysgerminoma (OCT4, CD117, D2‐40), yolk sac tumor (AFP, Glypican‐3), embryonal carcinoma (OCT4, CD30, SOX2), s...
Source: Histopathology - October 25, 2012 Category: Pathology Authors: Joseph T Rabban, Charles J Zaloudek Tags: Review Source Type: research

Mediastinal Mass Following Successful Chemotherapy for Ovary Dysgerminoma: Benign Process or Disease Relapse? A Case Report
Conclusions: Our case underlines the importance of knowing the age- and treatment-related incidence of physiologic thymic hyperplasia in young women with ovarian dysgerminoma in order to reduce the potential pitfalls and to avoid unnecessary invasive diagnostic procedures. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - October 17, 2012 Category: OBGYN Authors: Michele Guida, Antonia Gentile, Michele De Fazio, Antonio Cramarossa, Angela Sabatelli, Giuseppe Colucci Tags: Case Reports Source Type: research

The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland
Conclusions The incidence of gonadal GCTs in males increased significantly during the 40-year study period, whereas in females, no such change was observed. There were significant gender differences regarding the distribution of histological subtypes and patients’ ages. However, the incidence of extragonadal GCTs remained low in both sexes. The differences in the incidences of gonadal GCTs derived from the same population suggest that the risk factors of these malignancies differ between the two sexes. Content Type Journal ArticleCategory Original paperPages 1-7DOI 10.1007/s10552-012-0069-9Authors ...
Source: Cancer Causes and Control - September 25, 2012 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: research

Teratomas: A Multimodality Review
Germ cell tumors (GCTs) may occur in both children and adults and include a broad array of histologic subtypes, such as teratoma, seminoma (known as dysgerminoma in the ovary and germinoma in the pineal gland), choriocarcinoma, yolk sac tumor, embryonal cell carcinoma, and mixed GCT. In adults, GCTs occur most commonly in the gonads. In children, sacrococcygeal tumors predominate. Teratomas are a common form of GCT. They are defined histologically as containing tissues derived from all 3 germ cell layers: ectoderm, mesoderm (most teratomas contain fat, an imaging hallmark, which is a mesodermal derivative), and endoderm. T...
Source: Current Problems in Diagnostic Radiology - September 24, 2012 Category: Radiology Authors: Christine M. Peterson, Celine Buckley, Susan Holley, Christine O. Menias Tags: Original Articles Source Type: research

EPCAM–A novel molecular target for the treatment of pediatric and adult germ cell tumors
Abstract Germ cell tumors (GCTs) are thought to develop from totipotent primordial germ cells. Although the epithelial cell adhesion molecule (EPCAM) is expressed on embryonic stem cells as well as different tumor cells, it has not yet been extensively studied in GCTs. We analyzed EPCAM expression by quantitative RT‐PCR in 48 fresh‐frozen GCT specimens of different histology (10 mature teratoma, MT; 6 immature teratoma, IT; 7 dysgerminoma; 6 mixed malignant GCTs; 19 yolk sac tumor, YST) and in the GCT cell lines NCCIT, TE76.T, JAR and 2102Ep, and correlated its expression with AFP and hCG protein levels, histologic dif...
Source: Genes, Chromosomes and Cancer - September 14, 2012 Category: Cancer & Oncology Authors: Stefan Schönberger, Vera Okpanyi, Gabriele Calaminus, Sebastian Heikaus, Ivo Leuschner, James C. Nicholson, Nikolas H. Stoecklein, Dominik T. Schneider, Arndt Borkhardt Tags: Research Article Source Type: research

Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case.
We present two cases of gonadoblastoma associated with complete gonadal dysgenesis and Turner syndrome, respectively, with dysgerminoma overgrowth found in one case. We were interested in the DNA ploidy, the presence of Y chromosome DNA sequence and the status of chromosome 12p arm among the tumor cells. We performed cytophotometry to analyze the DNA content and fluorescence in situ hybridization (FISH) to identify the Y chromosome and the isochromosome 12p within the tumor cells. The cytophotometric result showed diploid DNA content in gonadoblastoma, whereas dysgerminoma revealed aneuploid DNA. The FISH result revealed Y...
Source: Pathology, Research and Practice - August 17, 2012 Category: Pathology Authors: Changchien YC, Haltrich I, Micsik T, Kiss E, Fónyad L, Papp G, Sápi Z Tags: Pathol Res Pract Source Type: research

Novel mutation of the sex‐determining region on the Y chromosome in a 46,XY female patient with monolateral dysgerminoma: A case report
We report a rare case of a 33‐year‐old 46,XY female patient, who presented with an adnexal mass suspected for dysgerminoma, with a novel mutation of the sex‐determining region on the Y chromosome consisting in the variant c.301C> G (p.L101V). Considering that effective screening is not available and the high risk of developing malignant neoplasm, prophylactic gonadectomy is mandatory. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 13, 2012 Category: OBGYN Authors: Francesco Battaglia, Francesco Plotti, Michela Angelucci, Alessia Aloisi, Roberto Angioli Source Type: research

Familial germ cell tumor
We present a family where the proband is a survivor of ovarian dysgerminoma stage IA. Her elder male sibling became acutely ill and was detected to have disseminated testicular malignancy with grossly elevated markers and vegetations in the mitral valve leaflets. Despite all measures he could not be saved. Presence of germ cell malignancies in the siblings of different sex in the same family points toward a genetic susceptibility. Literature review revealed only six similar cases. A discussion regarding the rare occurrence of familial germ cell malignancies with the affected family members may be worthwhile. (Source: India...
Source: Indian Journal of Human Genetics - May 26, 2012 Category: Genetics & Stem Cells Authors: Sanju CyriacRejeev RajendranathA Robert LouisTG Sagar Source Type: research

Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican‐3 in malignant germ cell tumors of the ovary
Conclusion: CD117 can be used as a diagnostic marker for dysgerminoma and YST. SALL4 is a more sensitive and specific marker for YSTs than glypican‐3. SALL4 and OCT4 are useful in distinguishing YST from dysgerminoma. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - March 27, 2012 Category: OBGYN Authors: Dat Tien TrinhKiyosumi ShibataTomoya HirosawaTomokazu UmezuMika MizunoHiroaki KajiyamaFumitaka Kikkawa Source Type: research

Retroperitoneal Mixed Germ Cell Tumor Mimicking a Renal Neoplasm: A Case Report
We present the first case of an 11-year-old girl with a retroperitoneal mixed GCT presenting with hypertension. (Source: Urology)
Source: Urology - March 26, 2012 Category: Urology & Nephrology Authors: Ting-Fu Su, Cheng-Ping Yu, Seng-Tang Wu, Shin-Nan Cheng, Hong-Hau Wang, Hsin-Chung Lin, Chih-Kung Lin Tags: Pediatric Case Reports Source Type: research

Gemistocytic Astrocytoma With PNET Tumor Arising Within a Mature Ovarian Teratoma and Seeding Metastasis in a Premenarchal Girl
Mature teratomas account for 20% of all ovarian neoplasms. While usually benign, these tumors are totipotent and can give rise to any type of malignancy. Common ovarian germ cell tumors (GCT) are dysgerminoma, endodermal sinus, and immature teratoma. On rare occasions, tumors of the central nervous system, such as PNET and medulloepithelioma, can arise in ovarian teratoma; however to date, a gemistocytic astrocytoma arising within an ovarian teratoma has never been reported in the literature nor the 5 year follow-up of such a patient. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - March 15, 2012 Category: OBGYN Authors: Candice Fraiser, Monique Regard, Mehmet Fevzi Ozkaynak, Mary Margaret Davis Tags: Poster Abstracts Source Type: research

Pure dysgerminoma of the ovary: a single institutional experience of 65 patients
Abstract Ovarian dysgerminomas are rare entity and account for only about 2% of all malignant ovarian neoplasm. The aim of this study was to evaluate the clinicopathologic characteristics, treatment, long-term survival, and fertility outcome of women diagnosed with ovarian dysgerminoma at our institution. Sixty-five women with histologically proven pure ovarian dysgerminoma were identified in this retrospective study. They were treated at King Faisal Specialist Hospital, Riyadh; Saudi Arabia between 1976 and 2010. The median age was 20 years. The most frequent symptoms at presentation were abdominal pai...
Source: Medical Oncology - March 9, 2012 Category: Cancer & Oncology Tags: Medical Oncology Source Type: research

Oophorectomy in children. Who and why: 13‐year experience in a single centre
Conclusion: Although ovarian pathology is uncommon in children, a girl presenting with acute lower abdominal pain or progressive abdominal distension should raise the suspicion and prompt immediate investigation to rule out ovarian torsion or ovarian neoplasms. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - March 7, 2012 Category: Pediatrics Authors: Yuen Shan WongYuk Him TamKristine Kit Yi PangJennifer Wai Cheung MouKin Wai ChanKim Hung Lee Source Type: research

Pineal germinoma with granulomatous reaction, often a pitfall in endoscopic biopsy. Report of two cases and review of the literature
Tumours of the pineal region are rare and account for 0.5–2% of all intracranial lesions. There is a higher incidence in male than in female and they are 10 times more common in children than in adults. Germinoma is the most common tumour in the pineal region appearing up to 50% of all pineal tumours . Intracranial germinomas are malignant neoplasms arising from remnants of primitive germ cells, which have failed to migrate to the genital crest during embryonic stage. Therefore germinomas present the same histology as seminomas and dysgerminomas, their gonadal counterparts. Intracranial germinoma is commonly situated in ...
Source: Clinical Neurology and Neurosurgery - January 27, 2012 Category: Neurosurgery Authors: K. Schmalisch, G. Pantazis, F.H. Ebner, A. Bornemann, J. Honegger, M. Tatagiba Tags: Case Reports Source Type: research

Bilateral dysgerminoma in a patient with a previous diagnosis of Swyer syndrome
AbstractA 16‐year‐old girl was referred to our center by her general physician because of primary amenorrhea. Her family history revealed an older sister with Swyer syndrome and gonadectomy at another institution. After thorough evaluation she received the same diagnosis, but unlike her sister, she refused gonadectomy. Four years later she presented with abdominal discomfort and a complex pelvic mass. She underwent exploratory laparotomy and histological examination revealed bilateral dysgerminoma without capsular invasion. The tumor was classified as stage IB. After surgery she underwent adjuvant chemotherapy with thr...
Source: Journal of Obstetrics and Gynaecology Research - December 19, 2011 Category: OBGYN Authors: Ana Isabel Duarte Mendonça MoreiraJosé Carlos SilvaMaria Soledade FerreiraAntónio Lanhoso Source Type: research

Fine needle aspiration cytology of Sertoli–Leydig cell tumors of ovary masquerading as dysgerminoma
AbstractHerein, we described a case of a 29‐year‐old female with a large ovarian mass. Fine needle aspiration cytology (FNAC) of the mass showed discrete round to oval cells in a fatty vacuolated background. FNAC diagnosis of dysgerminoma was suggested. The histology of the tumors showed features of poorly differentiated Sertoli–Leydig cell tumors. We discussed the diagnostic pitfalls of this case on FNAC. Diagn. Cytopathol. 2011. © 2011 Wiley Periodicals, Inc. (Source: Diagnostic Cytopathology)
Source: Diagnostic Cytopathology - November 18, 2011 Category: Pathology Authors: Sandeep Kumar Arora, Pranab Dey Tags: Brief Report Source Type: research

Surgical intervention strategies for pediatric ovarian tumors: experience with 60 cases at one institution
Conclusions The majority of pediatric ovarian tumors were benign disease, and the patients with malignant lesions had a good prognosis. In neonatal cases, an umbilical crease incision approach is feasible and provides excellent cosmesis. We recommend tumor resection with ovarian preservation through a minimally invasive approach (modified Rocky Davis incision) as the first line treatment for older pediatric patients with ovarian tumors other than those preoperatively diagnosed as malignant. Content Type Journal ArticleCategory Original articlePages 1-5DOI 10.1007/s00383-011-3004-3Authors Tatsuro Ta...
Source: Pediatric Surgery International - November 16, 2011 Category: Surgery Tags: Pediatric Surgery International Source Type: research

Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: A retrospective study of single institution.
Conclusions: Most malignant ovarian germ cell tumors have excellent prognoses with primary treatment, and good reproductive outcomes can be expected. Because primary treatment failure is associated with the residual disease after the salvage surgery, knowledge of the presence or absence of this risk factor may be helpful in risk stratification and individualization of adjuvant therapy in malignant ovarian germ cell tumors. Further large-scale prospective studies to confirm these results should be performed. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - October 11, 2011 Category: Cancer & Oncology Authors: Chung Won LeeMin Jong SongSung Taek ParkEun Young KiSung Jong LeeKeun Ho LeeKi Sung RyuJong Sup ParkSoo Young Hur Source Type: research

Dysgerminoma in the uterine cervix
In December 2006, a 24-year-old married woman presented to the All India Institute of Medical Sciences, New Delhi, India, with a 1-month history of abdominal pain. Examination revealed an abdominopelvic mass; ultrasound and computed tomography (CT) showed a solid cystic tumor originating from the right ovary and measuring 8×8cm. The level of cancer antigen 125 (CA-125) was 31.5 U/mL; the level of lactate dehydrogenase (LDH) was 2189 U/L; the level of α-fetoprotein was 2.5ng/mL; the level of β-human chorionic gonadotropin (hCG) was less than 1.2 U/mL. Laparoscopy revealed a right ovarian solid cystic tumor measuring 6×8...
Source: International Journal of Gynaecology and Obstetrics - October 5, 2011 Category: OBGYN Authors: Sunesh Kumar, Lalit Kumar, Debjyoti Karmakar, Rajni Safaya, Prashant Durgapal Tags: Brief communications Source Type: research

Dysgerminoma in a case of 46,XY Pure Gonadal Dysgenesis (Swyer syndrome): A Case Report
Simple 46, XY gonadal dysgenesis syndrome, also called Swyer syndrome, is known as pure gonadal dysgenesis. Individuals with the syndrome are characterized by 46, XY karyotype and phenotypically female with female genital appearance, normal Mullerian structures and absent testicular tissue. The condition usually first becomes apparent in adolescence with delayed puberty and primary amenorrhea due to the gonads have no hormonal or reproductive potential. Herein, we report a case of dysgerminoma diagnosed in a dysgenetic gonad of a 21-year-old patient with Swyer syndrome. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - September 19, 2011 Category: Pathology Authors: Yang HanYan WangQingchang LiShundong DaiAnguang HeEnhua Wang Source Type: research

RNA‐binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours
Conclusions: LIN28 is a sensitive marker for gonadoblastomas, dysgerminomas, ECs, and YSTs. LIN28 can be used to distinguish them from non‐GCTs. (Source: Histopathology)
Source: Histopathology - September 1, 2011 Category: Pathology Authors: Debin XueYan PengFenghua WangRobert W AllanDengfeng Cao Source Type: research

Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature
Conclusion Differential diagnosis of perimenarcheal vaginal bleeding may be challenging for the clinician. Rare causes such as pregnancy both intrauterine and extrauterine and hormone producing tumors should be kept in mind. Content Type Journal ArticleCategory Gynecologic OncologyPages 1-5DOI 10.1007/s00404-011-2073-9Authors Sertac Esin, Department of Obstetrics and Gynecology, Sami Ulus Maternity and Children’s Hospital, 42. Cadde, 18/9 Cukurambar, Ankara, TurkeyEralp Baser, Department of Obstetrics and Gynecology, Sami Ulus Maternity and Children’s Hospital, 42. Cadde, 18/9 Cukurambar, Ankara,...
Source: Archives of Gynecology and Obstetrics - August 30, 2011 Category: OBGYN Tags: Archives of Gynecology and Obstetrics Source Type: research

Ovarian cancer during pregnancy
Conclusion: Early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. Tumor staging is possible during pregnancy, but the appropriateness of surgery needs to be considered carefully. Ideally, the treatment strategy should be discussed and structured on an individual basis. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - August 29, 2011 Category: OBGYN Authors: Kazım Gezginç, Rengin Karataylı, Fatma Yazıcı, Ali Acar, Çetin Çelik, Metin Çapar Tags: Clinical articles Source Type: research

Insights on neoplastic stem cells from gel‐based proteomics of childhood germ cell tumors
Conclusion Differential regulation of FKBP4 and NF45, combined with previous research on immunosuppressant binding, suggests that glucocorticoid receptor signaling merits further investigation in cGCTs and NSCs. Pediatr Blood Cancer © 2011 Wiley‐Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - July 25, 2011 Category: Cancer & Oncology Authors: William E. HaskinsSruthi EedalaY.L. Avinash JadhavManbir S. LabhanVidya C. PericherlaElizabeth J. Perlman Tags: Research Article Source Type: research

Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours.
Germ cell tumours (GCTs) are cancers of the testis, ovary or extragonadal sites that occur in infants, children and adults. Testicular GCT is the most common cancer in young men aged 15-40 years. Abnormalities in developmental signalling pathways such as wnt/β-catenin, TGF-β/BMP and Hedgehog have been described in many childhood tumours. To date, however, the status of BMP signalling in GCTs has not been described. Herein, we examine BMP-SMAD signalling in a set of clinically-annotated paediatric GCTs. We find that BMP signalling activity is absent in undifferentiated tumours such as seminomas and dysgerminomas, bu...
Source: International Journal of Andrology - June 21, 2011 Category: Urology & Nephrology Authors: Fustino N, Rakheja D, Ateek CS, Neumann JC, Amatruda JF Tags: Int J Androl Source Type: research

Bone morphogenetic protein signalling activity distinguishes histological subsets of paediatric germ cell tumours
SummaryGerm cell tumours (GCTs) are cancers of the testis, ovary or extragonadal sites that occur in infants, children and adults. Testicular GCT is the most common cancer in young men aged 15–40 years. Abnormalities in developmental signalling pathways such as wnt/β‐catenin, TGF‐β/BMP and Hedgehog have been described in many childhood tumours. To date, however, the status of BMP signalling in GCTs has not been described. Herein, we examine BMP‐SMAD signalling in a set of clinically‐annotated paediatric GCTs. We find that BMP signalling activity is absent in undifferentiated tumours such as seminomas and dysg...
Source: International Journal of Andrology - June 21, 2011 Category: Sexual Medicine Authors: N. FustinoD. RakhejaC. S. AteekJ. C. NeumannJ. F. Amatruda Tags: ORIGINAL ARTICLE Source Type: research

Identification of novel SRY mutations and SF1 (NR5A1) changes in patients with pure gonadal dysgenesis and 46,XY karyotype
Primary amenorrhea due to 46,XY disorders of sexual development (DSD) is complex with the involvement of several genes. Karyotyping of such patients is important as they may develop dysgerminoma and molecular analysis is important to identify the underlying mechanism and explore the cascade of events occurring during sexual development. The present study was undertaken for the genetic analysis in seven patients from five families presenting with primary amenorrhea and diagnosed with pure gonadal dysgenesis. Karyotyping was done and the patients were screened for underlying changes in SRY, desert hedgehog (DHH), DAX1 (NR0B1...
Source: Molecular Human Reproduction - May 17, 2011 Category: Molecular Biology Authors: Paliwal, P., Sharma, A., Birla, S., Kriplani, A., Khadgawat, R., Sharma, A. Tags: Articles Source Type: research

Dysgerminoma and gonadal dysgenesis: The need for a new diagnosis tree for suspected ovarian tumours
Conclusions: In the case of a suspected ovarian tumour, delayed pubertal development, moderate βHCG level and elevated FSH level are clinical and biological clues to a diagnosis of dysgerminoma in the context of PGD and should prompt karyotype analysis before surgery. Because FSH is an efficient indirect marker of this condition, we suggest including this analysis in the management of gonadal tumours. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - March 13, 2011 Category: Urology & Nephrology Authors: Carmen Capito, Alexis Arnaud, Frederic Hameury, Benjamin Fremond, Hubert Lardy, Marc David Leclair, Yves Heloury Tags: Disorders of Sexual Development Source Type: research

Ovarian gonadoblastoma with dysgerminoma in a woman with 46XX karyotype
(Source: Pathology International)
Source: Pathology International - February 28, 2011 Category: Pathology Authors: Yu‐Jin KooYi‐Kyeong ChunYong‐Soon KwonIn‐Ho LeeTae‐Jin KimKi‐Heon LeeKyung‐Taek Lim Source Type: research

Imaging of gynecological disease (6): clinical and ultrasound characteristics of ovarian dysgerminoma
ConclusionThe ultrasound finding of a highly vascularized, large, solid, lobulated adnexal mass with irregular internal echogenicity in a woman 20–30 years old should raise the suspicion of ovarian dysgerminoma. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - February 7, 2011 Category: Radiology Authors: S. GuerrieroA. C. TestaD. TimmermanC. Van HolsbekeS. AjossaD. FischerovaD. FranchiF. P. G. LeoneE. DomaliJ. L. AlcazarG. ParodoF. MasciliniB. VirgilioV. N. DemidovJ. LipatenkovaL. Valentin Tags: Original Paper Source Type: research

Imaging of gynecological disease: clinical and ultrasound characteristics of ovarian dysgerminoma.
CONCLUSION: The ultrasound finding of a highly vascularized, large, solid, lobulated adnexal mass with irregular internal echogenicity in a woman 20-30 years old should raise a suspicion of ovarian dysgerminoma. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 21305635 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)
Source: The Ultrasound Review of Obstetrics and Gynecology - February 7, 2011 Category: Radiology Authors: Guerriero S, Testa AC, Timmerman D, Van Holsbeke C, Ajossa S, Fischerova D, Franchi D, Leone F, Domali E, Alcazar J, Parodo G, Mascilini F, Virgilio B, Demidov V, Lipatenkova J, Valentin L Tags: Ultrasound Obstet Gynecol Source Type: research

Imaging of gynecological disease: clinical and ultrasound characteristics of ovarian dysgerminoma
ConclusionThe ultrasound finding of a highly vascularized, large, solid, lobulated adnexal mass with irregular internal echogenicity in a woman 20‐30 years old should raise a suspicion of ovarian dysgerminoma. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - February 7, 2011 Category: Radiology Authors: S. GuerrieroA. C. TestaD. TimmermanC Van HolsbekeS AjossaD FischerovaD FranchiFPG LeoneE DomaliJL AlcazarG ParodoF MasciliniB VirgilioVN DemidovJ LipatenkovaL. Valentin Tags: Original Article Source Type: research

Primary retroperitoneal dysgerminoma presenting as an adrenal tumor: A case report and literature review
We report an undescribed case of primary retroperitoneal dysgerminoma presenting as an adrenal tumor in a 17‐year‐old girl. Surgery was performed on a 10 × 9.5 cm sized adrenal gland tumor and the resected tumor showed unequivocal histological features of dysgerminoma. The diagnosis was confirmed by the tumor's germ cell immunophenotype. Postoperative ultrasonography, CT and PET over a 6‐month period revealed no evidence of ovarian lesion. The patient is stable, but with a suspicious residual tumor after adjuvant chemotherapy. (Source: Pathology International)
Source: Pathology International - January 31, 2011 Category: Pathology Authors: Su Hyun YooKyu‐Rae KimSuk Jun HongKyung‐Ja Cho Source Type: research

Survival and reproductive outcomes in women treated for malignant ovarian germ cell tumors.
CONCLUSIONS: Overall survival was 100% among patients with both local and advanced MOGCTs, including those who underwent fertility-sparing surgery. Fertility-sparing surgery plus adjuvant chemotherapy appeared to have little or no effect on fertility or menstrual cycles. PMID: 21256579 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - January 19, 2011 Category: Cancer & Oncology Authors: Weinberg LE, Lurain JR, Singh DK, Schink JC Tags: Gynecol Oncol Source Type: research

Excision of extensive metastatic dysgerminoma to control refractory hypercalcaemia in a child at high risk for tumour-lysis syndrome
We present a child with refractory hypercalcaemia, bulky chemosensitive metastatic tumours and acute renal failure in whom chemotherapy posed high-risk of tumour lysis syndrome (TLS). Resection of the metastatic tumours successfully normalised the hypercalcaemia and represents a practical alternative control strategy in cases at high risk of TLS. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - December 31, 2010 Category: Surgery Authors: Wajid Jawaid, Valeria Solari, Lisa Howell, Edwin Jesudason Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: research

KIT gene mutation and amplification in dysgerminoma of the ovary
CONCLUSIONS:KIT mutations occur in approximately one‐third of cases of dysgerminomas and are associated with advanced stage at presentation. KIT is a potential therapeutic target for those dysgerminomas that have the mutation. Cancer 2010. © 2010 American Cancer Society. (Source: Cancer)
Source: Cancer - November 29, 2010 Category: Cancer & Oncology Authors: Liang ChengLawrence M. RothShaobo ZhangMingsheng WangMichael J. MortonWenxin ZhengFadi W. Abdul KarimRodolfo MontironiAntonio Lopez‐Beltran Tags: Original Article Source Type: research

Malignant germ cell tumors associated with Swyer syndrome
We present a case of 14‐year‐old female with 46, XY karyotype with choriocarcinoma in one gonad and dysgerminoma in the second one. Pediatr Blood Cancer. © 2010 Wiley‐Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 14, 2010 Category: Cancer & Oncology Authors: Teresa Stachowicz‐StencelAnna SynakiewiczEwa Iżycka‐ŚwieszewskaGrażyna Kobierska‐GulidaAnna Balcerska Tags: Brief Report Source Type: research

Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors
ConclusionsMethylation of APC and LOH 5q21‐22 in YSTs and teratomas provide evidence for involvement of APC in the accumulation of β‐catenin and activation of the WNT pathway. Our additional analyses suggest that APC is unlikely to be solely responsible for the formation and progression of childhood GCTs. Pediatr Blood Cancer. © 2010 Wiley‐Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 11, 2010 Category: Cancer & Oncology Authors: Vera OkpanyiDominik T. SchneiderSusanne ZahnSonja SieversGabriele CalaminusJames C. NicholsonRoger D. PalmerIvo LeuschnerArndt BorkhardtStefan Schönberger Tags: Research Article Source Type: research

[High-level HCG in non-gravidic situations: About two cases.]
Ovarian dysgerminoma is the most common germinal tumor in women; however, a lot of different symptoms can lead to its diagnosis. In the two cases reported here, misdiagnosis of ectopic pregnancy was first done because of inappropriate secretion of HCG by the tumor. These two cases point out the particularity of dysgerminoma with its various secretion capacity. Conversely, facing a raised level of HCG in non-gravidic situation, physicians have to consider different gynaecological and extragynaecological hypothesis. PMID: 20950964 [PubMed - as supplied by publisher] (Source: Journal de Gynecologie, Obstetrique et Bio...
Source: Journal de Gynecologie, Obstetrique et Biologie de la Reproduction - October 12, 2010 Category: OBGYN Authors: Schmitt C, Lamblin G, Buenerd A, Mellier G Tags: J Gynecol Obstet Biol Reprod (Paris) Source Type: research

Malignant Mixed Ovarian Germ Cell Tumor with Embryonal Component
Conclusions: Malignant germ cell tumors frequently affect adolescent women of reproductive age. Management of these tumors requires consideration of fertility sparing surgical techniques and chemotherapy management. Using these techniques, the vast majority of patients will maintain their ovarian function and the ability to bear children after their recovery. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - September 27, 2010 Category: OBGYN Authors: Natalie Catharine Moniaga, Leslie M. Randall Tags: Case Reports Source Type: research

Gonadal dysgenesis and gynecologic cancer.
CONCLUSION:: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea. PMID: 20664451 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - July 29, 2010 Category: OBGYN Authors: Jonson AL, Geller MA, Dickson EL Tags: Obstet Gynecol Source Type: research

The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastoma
Summary: Gonadoblastoma is a rare gonadal neoplasm that occurs almost exclusively in individuals who are phenotypically females. Most cases develop in women who have an abnormal karyotype in which at least a portion of the centromeric region of the short arm of chromosome Y is present, a region often referred to as the GBY locus. Of the several genes present in the GBY locus, the TSPY1 gene (which encodes testis-specific protein, a protein thought to have a role in cell cycle regulation) appears to be the most likely to have a critical role in the pathogenesis of gonadoblastoma. To evaluate the association of TSPY1 with th...
Source: Human Pathology - July 25, 2010 Category: Pathology Authors: Johann D. Hertel, Phyllis C. Huettner, Louis P. Dehner, John D. Pfeifer Tags: Original Contributions Source Type: research

Gonadoblastoma: an unusual ovarian tumor
In this study, we reviewed 3 gonadoblastoma cases, 2 of which were bilateral, in patients 21, 17, and 18 years of age. Two of them presented 46 XY karyotype and gonadal dysgenesis, whereas the third presented 46 XX karyotype. Besides, 2 of the cases were associated to dysgerminomas. In all the cases, the histologic examination showed germ cell proliferation and sex cords derivatives frequently surrounding small round deposits containing amorphous hyaline material resembling Call-Exner bodies. One of the patients died at 8 years from diagnosis because of dysgerminoma multiple metastases, one is alive with no evidence of dis...
Source: Annals of Diagnostic Pathology - July 16, 2010 Category: Pathology Authors: Mario Gorosito, Belén Pancera, Sandra Sarancone, Ana Lía Nocito Tags: Original Contributions Source Type: research

Atypical presentation and management dilemma of mixed gonadal dysgenesis
Conclusion(s): Mixed gonadal dysgenesis involves inherent malignancy risk and complex psychosocial issues, which necessitate a multidisciplinary approach to diagnosis and treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - July 14, 2010 Category: Reproduction Medicine Authors: Katherine K. McKnight, G. Wright Bates Tags: Case report summaries Source Type: research