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Non-reducible disulfide bond replacement implies that disulfide exchange is not required for hepcidin-ferroportin interaction
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC00328B, CommunicationDong-Liang Huang, JingSi Bai, Meng Wu, Xia Wang, Bernd Riedl, Elisabeth Pook, Carsten Alt, Marion Erny, Yi-Ming Li, Donald Bierer, Jing Shi, Gemin Fang Previous studies have led to opposing hypotheses about the requirement of intermolecular disulfide exchange in the binding of the iron regulatory peptide hepcidin to its receptor ferroportin. To clarify this... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 8, 2019 Category: Chemistry Authors: Dong-Liang Huang Source Type: research
Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin
CONCLUSION: USP35 modulates ferroptosis in lung cancer via targeting FPN, and it is a promising therapeutic target to lung cancer.PMID:33931967 | DOI:10.1002/ctm2.390
Source: Clinical Lung Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Zheng Tang Wanli Jiang Ming Mao Jinping Zhao Jiakuan Chen Nitao Cheng Source Type: research
Metabolic iron detection through divalent metal transporter 1 and ferroportin mediated cocktail fluorogenic probes
Chem Commun (Camb). 2021 Jul 20. doi: 10.1039/d1cc03150c. Online ahead of print.ABSTRACTA cocktail [1 + 2] dual-fluorescent probe system was developed to realize the real-time visualization of dynamic iron state changes between Fe2+ and Fe3+ at the cellular level and in multicellular organisms, providing insights into the effect of DMT1 and ferroportin on iron regulation.PMID:34286752 | DOI:10.1039/d1cc03150c
Source: Chemical Communications - July 21, 2021 Category: Chemistry Authors: Yu-Qiang Zhao Jiahong Duan Le Yu Ilwha Kim Yumin Wang Yi-Cheng Ma Cheng-Gang Zou Ying Zhou Jun Feng Zhang Jong Seung Kim Source Type: research
Myeloid specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice
Am J Physiol Endocrinol Metab. 2021 Aug 2. doi: 10.1152/ajpendo.00116.2021. Online ahead of print.ABSTRACTTissue iron overload is associated with insulin resistance and mitochondrial dysfunction in rodents and humans; however, the mechanisms or cell types that mediate this phenotype are not completely understood. Macrophages (Mɸ)s are known to contribute to iron handling; thus, we hypothesized that perturbed iron handling by Mɸs impairs mitochondrial energetics and evokes systemic insulin resistance in mice. Male and female mice with myeloid targeted (LysMCre) deletion of the canonical iron exporter, ferroportin (Fpn, en...
Source: Am J Physiol Endocri... - August 2, 2021 Category: Endocrinology Authors: Nathan C Winn Elysa M Wolf Matthew A Cottam Monica Bhanot Alyssa H Hasty Source Type: research
