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Sub-millimolar concentration of the novel phenol-based compound, 2-hydroxy benzoate zinc, induces apoptosis in human HT-1080 fibrosarcoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate that the novel phenolic compound 2HBZ is a potent apoptosis-inducing agent in HT-1080 cells and warrants further investigation as a potential chemotherapeutic agent in primary cancer cell models. (Source: Cell Proliferation)
Source: Cell Proliferation - November 18, 2009 Category: Cytology Authors: J. G. Mahdi, C. J. Pepper, M. A. Alkarrawi, A. J. Mahdi, I. D. Bowen Source Type: journals

Establishment and characterization of a novel human malignant peripheral nerve sheath tumor cell line, FMS-1, that overexpresses epidermal growth factor receptor and cyclooxygenase-2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma. We established a new human MPNST cell line (designated FMS-1) from MPNST of the right brachial plexus of a 69-year-old woman with NF1. The cell line has been maintained for >24 months with >100 passages. FMS-1 cells showed a fibrosarcoma-like or epithelioid pattern in the heterotransplanted tumor, compared with a fascicular growth pattern of short-spindle tumor cells in the primary tumor. Immunophenotypically, FMS-1 cells showed almost the same characteristics as the primary tumor. Cytogenetic and molecular ana...
Source: Virchows Archiv - November 17, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Infantile Fibrosarcoma: Management based on European experienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: JCO Area: News The Journal of Clinical Oncology has featured a retrospective case review of infants under the age of 2 years with fibrosarcoma. The early online publication retrospectively analyses the clinical features and results of treatment in 56 infants with the condition, who were enrolled into the cooperative European protocols between 1979 and 2005 and treated with a combination of surgery and chemotherapy. The primary tumour site was the limbs in 66% of patients. According to the researchers, response rate to chemotherapy was 75%, and the specific response rate to vincristine-dactino...
Source: NeLM - Oncology - November 17, 2009 Category: Cancer & Oncology Source Type: organizations

Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: Application of an enzyme based oxygen deficiency system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mild hypothermia and pharmacological postconditioning are widespread therapeutical treatment options that positively influence the clinical outcome after tissue hypoxia. In the study presented, a two-enzyme based in-vitro oxygen deficiency model in combination with cultured HT-1080 fibrosarcoma cells was employed to mimic the in-vivo situation of hypoxia and to evaluate the influence of mild hypothermia and postconditioning with catalase on hypoxia-mediated cell damage. Using the in-vitro oxygen deficiency model, partial pressure of oxygen was rapidly reduced to levels below 5mmHg in the culture media and cells respond...
Source: European Journal of Pharmacology - November 13, 2009 Category: Drugs & Pharmacology Authors: Zitta K, Meybohm P, Bein B, Rodde C, Steinfath M, Scholz J, Albrecht M Tags: Eur J Pharmacol Source Type: journals

The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Integrin alpha11beta1 is expressed by ectomesenchymally- and mesodermally- derived fibroblasts and is the major collagen receptor on embryonic fibroblasts. We have previously characterized a 3kb human alpha11 promoter region in vitro. In the current study we generated promoter-LacZ reporter transgenic mice to examine the ability of the 3kb alpha11 promoter to drive tissue-specific expression also in vivo. Our data show that the alpha11 promoter region that we have characterized contains most of the regulatory elements that direct ectomesenchymal and mesodermal fibroblast-specific expression. Not much is known about int...
Source: Matrix Biology - November 11, 2009 Category: Molecular Biology Authors: Lu N, Ranta J, Heuchel R, Soininen R, Gullberg D Tags: Matrix Biol Source Type: journals

alpha-tocopheryl phosphate suppresses tumor invasion concurrently with dynamic morphological changes and delocalization of cortactin from invadopodia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
alpha-tocopheryl phosphate (TocP) has been elucidated for diverse effectiveness through unequivocal mechanisms independent of its conversion to alpha-tocopherol (Toc). The present study showed that TocP, in a dose-dependent manner, repressed invasion of human fibrosarcoma HT-1080 cells through the basement membrane, more markedly than Toc and several other Toc derivatives, although no cytotoxic effect was shown in either HT-1080 cells or human skin dermal fibroblastic cells DUMS-16. TocP diminished intracellular reactive oxygen species such as peroxides, lipid hydroperoxides and superoxide anion radicals in HT-1080 cel...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Saitoh Y, Yumoto A, Miwa N Tags: Int J Oncol Source Type: journals

MR Imaging of Soft Tissue Masses in ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the role of MR imaging in the evaluation of musculoskeletal soft tissue masses, reviewing limitations in its ability to establish tissue diagnosis and its critical role in determining lesion extent. It also reviews benign soft tissue masses, such as fibrous lesions, popliteal cysts, lipomatous lesions, and neurofibromatous tumors. Reactive entities, such as abscess, myositis ossificans, and hemangioma, are discussed. Differentiation between high- and low-flow vascular and lymphatic anomalies is reviewed. The article concludes with a discussion of the uncommon malignant musculoskeletal soft tissue tum...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Rebecca Stein-Wexler Source Type: journals

MR imaging of soft tissue masses in children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article discusses the role of MR imaging in the evaluation of musculoskeletal soft tissue masses, reviewing limitations in its ability to establish tissue diagnosis and its critical role in determining lesion extent. It also reviews benign soft tissue masses, such as fibrous lesions, popliteal cysts, lipomatous lesions, and neurofibromatous tumors. Reactive entities, such as abscess, myositis ossificans, and hemangioma, are discussed. Differentiation between high- and low-flow vascular and lymphatic anomalies is reviewed. The article concludes with a discussion of the uncommon malignant musculoskeletal soft tissue tum...
Source: Radiologic Clinics of North America - November 1, 2009 Category: Radiology Authors: Stein-Wexler R Tags: Radiol Clin North Am Source Type: journals

Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone - An array comparative genomic hybridization studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our analysis provided novel findings that can be exploited when searching for markers for diagnosis and prognosis, and targets of therapy in this tumor type. © 2009 Wiley-Liss, Inc. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - October 27, 2009 Category: Cancer & Oncology Authors: Tarja Niini, José Antonio López-Guerrero, Shinsuke Ninomiya, Mohamed Guled, Claudia Maria Hattinger, Francesca Michelacci, Tom Böhling, Antonio Llombart-Bosch, Piero Picci, Massimo Serra, Sakari Knuutila Source Type: journals

Increasing incidence rates of soft tissue sarcomas? A population-based epidemiologic study and literature review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study has analyzed the most recent data from a European population in comparison with seven international studies. An increase, as postulated elsewhere, could not be confirmed. The incidence rate of STS in Austria ranges in the lower half of the international incidence rates (1.8-5.0 per 100 000 per year). Different inclusion criteria (Kaposi's sarcoma and dermatofibrosarcoma) and classifications in the various studies explain the increase of incidence in some studies rather than true increase of STS due to new or accumulated risk factors. PMID: 19858086 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2009 Category: Cancer & Oncology Authors: Wibmer C, Leithner A, Zielonke N, Sperl M, Windhager R Tags: Ann Oncol Source Type: journals

Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anticancer activities of various extracts of the medicinal mushroom, Ganoderma lucidum, have been widely demonstrated and are mainly associated with the presence of different bioactive polysaccharides and triterpenoids. We have evaluated and compared in vitro and in vivo the antitumor effects of two preparations from Ganoderma lucidum: a methanol extract containing total terpenoids (GLme) and a purified methanol extract containing mainly acidic terpenoids (GLpme). Both extracts inhibited tumor growth of B16 mouse melanoma cells inoculated subcutaneously into syngeneic C57BL/6 mice and reduced viability of B16 cells in ...
Source: Nutrition and Cancer - October 22, 2009 Category: Cancer & Oncology Authors: Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID, Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD Tags: Nutr Cancer Source Type: journals

Western blot trouble-shootingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A community member seeks advice on experiments in a fibrosarcoma cell line (Source: The Scientist)
Source: The Scientist - October 12, 2009 Category: Science Authors: The Scientist Community Source Type: info

Rectal Intussusception due to Re-Recurrent Ovarian Fibrosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Reviewing the literature, it is recommended that all patients should primarily be operated on and generally be followed up closely. In patients with incomplete resection, palliative chemo- and/or radiotherapy is recommended. In our opinion, in patients with complete resection, adjuvant chemo- and/or radiotherapy should be considered. Only in patients with high-grade fibrosarcomas, adjuvant intra- or postoperative radiotherapy should be applied. PMID: 19816077 [PubMed - as supplied by publisher] (Source: Onkologie)
Source: Onkologie - October 11, 2009 Category: Cancer & Oncology Authors: Langner I, Glitsch A, Kruger W, Vogelgesang S, Langner S, von Bernstorff W, Heidecke CD Tags: Onkologie Source Type: journals

Primary fibrosarcoma of the diaphragm with pleural effusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 8, 2009 Category: Respiratory Medicine Authors: Hong Zhang, Dandan Wu, Zhen Wang, Jun Xu, Huiying Wang Source Type: journals

{beta}-Cell-Specific Overexpression of Glutathione Peroxidase Preserves Intranuclear MafA and Reverses Diabetes in db/db Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic hyperglycemia causes oxidative stress, which contributes to damage in various tissues and cells, including pancreatic beta-cells. The expression levels of antioxidant enzymes in the islet are low compared with other tissues, rendering the beta-cell more susceptible to damage caused by hyperglycemia. The aim of this study was to investigate whether increasing levels of endogenous glutathione peroxidase-1 (GPx-1), specifically in beta-cells, can protect them against the adverse effects of chronic hyperglycemia and assess mechanisms that may be involved. C57BLKS/J mice overexpressing the antioxidant enzyme GPx-1 o...
Source: Endocrinology - October 8, 2009 Category: Endocrinology Authors: Harmon JS, Bogdani M, Parazzoli SD, Mak SS, Oseid EA, Berghmans M, Leboeuf RC, Robertson RP Tags: Endocrinology Source Type: journals

Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO2) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells. We found that mice that were cotransplanted subcutaneously with QR-32 cells and nano-sized TiO2, either uncoated (TiO2-1, hydrophilic) or coated with stearic acid (TiO2-2, hydrophobic), did not form tumors. However, QR-32 cells became tumorigenic after injection into sites previously implanted with TiO2-1, but not TiO2-2, and these devel...
Source: The American Journal of Pathology - October 7, 2009 Category: Pathology Authors: Onuma K, Sato Y, Ogawara S, Shirasawa N, Kobayashi M, Yoshitake J, Yoshimura T, Iigo M, Fujii J, Okada F Tags: Am J Pathol Source Type: journals

Induction of neoplastic transformation by ectopic expression of human aldo-keto reductase 1C isoforms in NIH3T3 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that several isoforms of aldo-keto reductase 1C (AKR1C) were overexpressed in arsenic-exposed HaCaT cells. The AKR1C family of proteins are phase I drug-metabolizing enzymes involved in maintenance of steroid homeostasis, prostaglandin metabolism and metabolic activation of polycyclic aromatic hydrocarbons. To explore the oncogenic potential of AKR1C isoforms, we established mouse NIH3T3 cell lines ectopically and stably expressing human AKR1C1, AKR1C2 or AKR1C3. Our results showed that ectopic expression of human AKR1C1 and AKR1C2, but not AKR1C3, significantly enhanced foci formation. Following su...
Source: Carcinogenesis - October 6, 2009 Category: Cancer & Oncology Authors: Chien, C.-W., Ho, I-C., Lee, T.-C. Tags: CARCINOGENESIS Source Type: journals

Fucoidan-Vitamin C complex suppresses tumor invasion through the basement membrane, with scarce injuries to normal or tumor cells, via decreases in oxidative stress and matrix metalloproteinases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fucoidan (Fucdn) and vitamin C (VC) were saturatedly dissolved in water and lyophilized and thoroughly ethanol-rinsed until no detection for supernatant vitamin C to form the Fucdn-VC (1:0.23 wt/wt) inclusion body (Fucdn-VC-IB). Fucdn-VC-IB increased not only VC-stabilizing at 37 degrees C, but also hydroxyl-radical scavenging as shown by ESR/spin-trap method, more markedly than a mere mixture of Fucdn:VC (1:0.23 wt/wt). Invasion of human fibrosarcoma cells HT-1080 through the basement membrane was repressed by Fucdn-VC-IB of non-cytotoxic concentrations without significant inhibition to human skin dermal fibroblasts D...
Source: International Journal of Oncology - October 1, 2009 Category: Cancer & Oncology Authors: Saitoh Y, Nagai Y, Miwa N Tags: Int J Oncol Source Type: journals

Endobronchial metastasis from oral fibrosarcoma 13 years after treatment of primary tumor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We described a 56-year-old woman with EBM of oral fibrosarcoma with local recurrence 13 years after treatment of primary tumor. We conclude that the possibility of central airway metastasis should be kept in mind if patients with a past history of malignancy present with symptoms consistent with bronchial tumors, even if there are 13 years interval. Of several mechanisms EBM, we assume direct aspiration and implantation of tumor cells to bronchus from oral cancer. PMID: 19787473 [PubMed - in process] (Source: Tuberkuloz ve Toraks)
Source: Tuberkuloz ve Toraks - September 30, 2009 Category: Respiratory Medicine Authors: Rahimi-Rad MH, Ilkhanizadeh B Tags: Tuberk Toraks Source Type: journals

[11C]Gefitinib ([11C]Iressa): Radiosynthesis, In Vitro Uptake, and In Vivo Imaging of Intact Murine FibrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results demonstrated the promising potential of [11C]gefitinib to serve as a PET ligand for in vivo imaging of NFSa-bearing mice. Content Type Journal ArticleCategory Research ArticleDOI 10.1007/s11307-009-0265-5Authors Ming-Rong Zhang, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanKatsushi Kumata, National Institute of Radiological Sciences Department of Molecular Probes, Molecular Imaging Center 4-9-1 Anagawa, Inage-ku Chiba JapanAkiko Hatori, National Institute of Radiological Sciences Departmen...
Source: Molecular Imaging and Biology - September 29, 2009 Category: Molecular Biology Tags: Molecular Imaging and Biology Source Type: journals

Local and systemic antitumor effect of intratumoral and peritumoral IL-12 electrogene therapy on murine sarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we evaluated the antitumor effect of IL-12 electrogene therapy (EGT) on murine SA-1 fibrosarcoma. The therapeutic plasmid was injected either intratumorally into subcutaneous SA-1 nodules or intradermally into the peritumoral region. We achieved a remarkable local and systemic antitumor effect with both approaches after single plasmid DNA application, with significant intratumoral and systemic production of IL-12 and IFNgamma. Intratumoral IL-12 EGT resulted in over 90% complete response rate of the treated tumors with 60% of cured mice being resistant to challenge with SA-1 tumor cells. Peritumoral EGT resu...
Source: Cancer Biology and Therapy - September 18, 2009 Category: Cancer & Oncology Authors: Pavlin D, Cemazar M, Kamensek U, Tozon N, Pogacnik A, Sersa G Tags: Cancer Biol Ther Source Type: journals

Giant neoplastic omental cyst masquerading as ascites: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Neglected omental cysts as in this case may grow to enormous size, undergo malignant transformation and poses serious diagnostic and surgical challenges. (Source: Cases Journal)
Source: Cases Journal - September 15, 2009 Category: Journals (General) Source Type: journals

Brachial neuropathy 22 years after radiation therapy for fibrosarcoma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case report presents a 56-year-old man with right upper limb weakness which arose 22 years after initial local radiation treatment for a grade III fibrosarcoma. Nerve conduction studies revealed impairment of all three major upper limb nerves compared with the left, with particular impairment of the median and ulnar nerves in the most fibrotic area that had been irradiated. In addition, the patient received multiple courses of chemotherapy. The occurrence of radiation-induced brachial plexopathy should be considered in patients presenting with limb pain or weakness even many years after radiation therapy. (Source: Cases Journal)
Source: Cases Journal - September 14, 2009 Category: Journals (General) Source Type: journals

Targeted Delivery of Chemotherapeutic Agents Using Improved Radiosensitive Liquid Core Microcapsules and Assessment of Their Antitumor EffectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results of our study have shown that our liquid core microcapsules can be used in radiotherapy for targeted delivery of chemotherapeutic agents. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - September 7, 2009 Category: Radiology Authors: Satoshi Harada, Shigeru Ehara, Keizo Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takahiro Sato, Shyoichi Oikawa, Tomihiro Kamiya, Kazuo Arakawa, Wataru Yokota, Koichiro Sera, Jyun Ito Tags: 5th JUCTS and the 5th S. Takahashi Memorial International Joint Symposium Source Type: journals

Acute molecular response of mouse hindlimb muscles to chronic stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stimulation of the mouse hindlimb via the sciatic nerve was performed for a 4-h period to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 ± 0.1 g/g body wt) declined 45% within 10 min and was maintained for the remainder of the experiment. Force returned to initial levels upon study completion. An immediate-early growth response was present in the extensor digitorum longus (EDL) muscle (FOS, JUN, activating transcription factor 3, and musculoaponeurotic fibrosarcoma oncogene) with a similar but attenuated pattern in the soleus muscle. Transcript profi...
Source: AJP: Cell Physiology - September 4, 2009 Category: Cytology Authors: LaFramboise, W. A., Jayaraman, R. C., Bombach, K. L., Ankrapp, D. P., Krill-Burger, J. M., Sciulli, C. M., Petrosko, P., Wiseman, R. W. Tags: MUSCLE CELL BIOLOGY AND CELL MOTILITY Source Type: journals

Sclerosing epithelioid fibrosarcoma of the liver infiltrating the inferior vena cava.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 39-year-old man with SEF of the liver, which infiltrated the inferior vena cava (IVC). The SEF of the liver was successfully resected, and the infiltrated IVC was also removed together with the liver tumor. Histopathological examination of the tumor showed typical histopathology of SEF. Immunohistochemically, the tumor was positive for vimentin. Recurrence was noted 7 mo after surgery. After chemotherapy, the recurrent tumor was resected surgically, and histopathological examination showed similar findings to those of the primary tumor. To our knowledge, this is the first report of SEF of the liver with tumor i...
Source: World Journal of Gastroenterology : WJG - September 4, 2009 Category: Gastroenterology Authors: Tomimaru Y, Nagano H, Marubashi S, Kobayashi S, Eguchi H, Takeda Y, Tanemura M, Kitagawa T, Umeshita K, Hashimoto N, Yoshikawa H, Wakasa K, Doki Y, Mori M Tags: World J Gastroenterol Source Type: journals

A novel mutated cell line with characteristics of dedifferentiated chondrosarcoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, a novel dedifferentiated CS cell line, MS0812, was spontaneously established from mutated human embryonic muscle cells. Several features of the cell line were investigated, including growth characteristics, cytogenetics, electron microscopic features, expression of various antigenic markers and tumor formation. MS0812 has been cultured continuously for more than 3 years. The growth characteristics of MS0812 are similar to the immortalized cell lines as reported. The cell line exhibited complex karyotypes and hyperploidy, the chromosome number ranged from 50 to 158. MS0812 was positive for vimentin, desmin an...
Source: International Journal of Molecular Medicine - September 3, 2009 Category: Molecular Biology Authors: Yang L, Chen Q, Zhang S, Wang X, Li W, Wen J, Huang X, Zheng J, Huang G, Huang T, Ju G Tags: Int J Mol Med Source Type: journals

Tumor cells expressing tissue factor influence the migration of smooth muscle cells in a catalytic activity-dependent way.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The expression of tissue factor (TF) in tumors reportedly exacerbates the aggressiveness of several types of cancers. The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intravascular coagulation in specific cancers. Furthermore, the intracellular signaling that is elicited after the formation of the TF / coagulation factor VIIa complex at the cell membrane modulates the activity of adhesion molecules and mitogen-activated protein (MAP) kinases. To evaluate whether TF overexpr...
Source: Canadian Journal of Physiology and Pharmacology - August 31, 2009 Category: Drugs & Pharmacology Authors: Brousseau C, Morissette G, Fortin JP, Marceau F, Petitclerc E Tags: Can J Physiol Pharmacol Source Type: journals

Rapid sarcomatous transformation of an ameloblastic fibroma of the mandible: Case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an extremely rare, rapidly progressive, and fatal case originating in the posterior mandible of a 20-year old female patient. Initially histopathologically diagnosed as a benign lesion, it rapidly recurred with apparent transformation into a high-grade sarcoma over a period of 6 months. Subsequent intracranial and pulmonary metastases were noted, and the patient died within 15 months of initial consultation. This case emphasizes the need for a high element of suspicion about clinically ambiguous lesions. We recommend more extensive or radical, primary excisions in lesions that have a known potential for recurrenc...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2009 Category: ENT & OMF Authors: Aisha Kousar, Mervyn M. Hosein, Zubair Ahmed, Khurram Minhas Tags: Online Only Articles Source Type: journals

The Thioxotriazole Copper(II) Complex A0 Induces Endoplasmic Reticulum Stress and Paraptotic Death in Human Cancer Cells [Molecular Basis Of Cell and Developmental Biology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The copper(II) complex A0 induces a type of non-apoptotic cell death also known as paraptosis. Paraptosis involves extensive endoplasmic reticulum vacuolization in the absence of caspase activation. A wide panel of human cancer cell lines was used to demonstrate differences in cytotoxicity by the paraptosis-inducing drug A0 and the metal-based pro-apoptotic drug cisplatin. Gene expression profiling of the human fibrosarcoma HT1080 cells showed that, while cisplatin induced p53 targets, A0 up-regulated genes involved in the unfolded protein response (UPR) and response to heavy metals. The cytotoxic effects of A0 were associ...
Source: Journal of Biological Chemistry - August 27, 2009 Category: Chemistry Authors: Tardito, S., Isella, C., Medico, E., Marchio, L., Bevilacqua, E., Hatzoglou, M., Bussolati, O., Franchi-Gazzola, R. Tags: Molecular Basis Of Cell and Developmental Biology Source Type: journals

Naloxone can improve the anti-tumor immunity by reducing the CD4(+)CD25(+)Foxp3(+) regulatory T cells in BALB/c mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New strategies that stimulate cell-mediated immunity (CMI) against tumors and inhibit regulatory T cells are needed to improve the outcome of cancer immunotherapy. The aim of this study was to enhance the anti-tumor immunity of gp96 vaccine through naloxone administration. Therefore, we used BALB\c mouse model of fibrosarcoma tumor and analyzed the tumor size, splenocytes proliferation, spleen and tumor infiltrated lymphocytes. Tumor and spleen CD4(+)CD25(+)Foxp3(+) regulatory T lymphocytes, cytotoxicity activity of the splenocytes, IFN-gamma and IL-4 secretion were assessed to describe the anti-tumor immune response. ...
Source: International Immunopharmacology - August 21, 2009 Category: Allergy & Immunology Authors: Hassan AT, Hassan ZM, Moazzeni SM, Mostafaie A, Shahabi S, Ebtekar M, Hashemi SM Tags: Int Immunopharmacol Source Type: journals

Neoplastic and Non-neoplastic Changes in F-344 Rats Treated with Naveglitazar, a g-Dominant PPAR a/g Agonist.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The carcinogenic potential of naveglitazar, a gamma-dominant peroxisome proliferator-activated receptor (PPAR) alpha/gamma dual agonist, was evaluated in a two-year study in F344 rats (0, 0.3, 1.0, or 3.0 mg/kg, males; 0, 0.1, 0.3, or 1.0 mg/kg, females). Increased mortality in male rats of the high-dose group was related to cardiac-associated lesions, neoplasms, and undetermined causes. Degeneration and hypertrophy of the myocardium occurred with dose-responsive increased incidence and severity. Neoplasms with increased incidence included sarcomas in male rats and urinary bladder neoplasms in female rats. Most sarcoma...
Source: Toxicologic Pathology - August 20, 2009 Category: Pathology Authors: Long GG, Reynolds VL, Dochterman LW, Ryan TE Tags: Toxicol Pathol Source Type: journals

Oridonin induces G(2)/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, oridonin induces L929 cell G(2)/M arrest and apoptosis, which is regulated by promoting ERK-p53 apoptotic pathway and suppressing PTK-mediated survival pathway. PMID: 19699177 [PubMed - as supplied by publisher] (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - August 18, 2009 Category: Biochemistry Authors: Cheng Y, Qiu F, Ye YC, Tashiro SI, Onodera S, Takashi I Tags: Arch Biochem Biophys Source Type: journals

Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080 cells. Downregulation of Rac1 using specific siRNA probes resulted in cell rounding, markedly decreased spreading, adhesion, and chemotaxis of HT1080 cells. 2D migration on laminin-coated surfaces in contrast was not markedly affected. Selective Rac2 depletion did not affect cell morphology, cell adhesion, and 2D migration, but significantly reduced chemotaxis. Downreg...
Source: Biochemical and Biophysical Research communications - August 14, 2009 Category: Biochemistry Authors: Niggli V, Schlicht D, Affentranger S Tags: Biochem Biophys Res Commun Source Type: journals

Odontogenic fibrosarcomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent report, described a case of low-grade fibrosarcoma of the mandible with probable origin from the dental follicle of an unerupted third molar. The authors stated that such a tumour has not been previously documented. I would like to call attention to three earlier reports by Thoma, the first in 1940 (), the second in 1949 () and the third in 1951 (). Thoma, a pioneer of modern oral pathology, presented a well-documented case, presumably the first described, of pericoronal fibrosarcoma in association with an unerupted mandibular third molar. He coined the term “odontogenic fibrosarcoma” for this lesion and po...
Source: Journal of Cranio-Maxillofacial Surgery - August 11, 2009 Category: ENT & OMF Authors: Fumio Ide Source Type: journals

Improvement of dendritic cell based therapeutic cancer vaccine with components of Toxoplasma Gondii.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of Dendritic cells (DCs) as a cellular adjuvant is a promising approach in immunotherapy of cancer. It has been previously demonstrated that dendritic cells (DCs) pulsed ex vivo with Toxoplasma gondii antigens trigger a systemic Th1-biased specific immune response and induce a protective and specific anti-toxoplasma immunity. In the present study, we demonstrate that tumor antigen pulsed DCs matured in the presence of Toxoplasma gondii components induce a potent anti-tumor response in a mouse model of fibrosarcoma. Bone-marrow derived DCs (BMDCs) were cultured in the presence of GM-CSF and IL-4. After 5 days, t...
Source: Clinical and Vaccine Immunology - August 4, 2009 Category: Allergy & Immunology Authors: Motamedi M, Arab S, Moazzeni SM, Khamis Abadi M, Hadjati J Tags: Clin Vaccine Immunol Source Type: journals

Enhancement of Th1 immune response by CD8alpha(+) dendritic cells loaded with heat shock proteins enriched tumor extract in tumor-bearing mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The discovery of dendritic cells (DCs) as professional antigen presenting cells has opened up new possibilities for their use in the development of tumor vaccines. We investigated the effect of the CD8alpha(+) DCs loaded with heat-treated tumor lysate (HTL) as a vaccine in tumor immunotherapy. The HTL loaded CD8alpha(+) DCs, TL loaded CD8alpha(+) DCs and unloaded CD8alpha(+) DCs were subcutaneously injected in the fibrosarcoma-bearing mice. The splenocyte proliferation and the shifting of Th1/Th2 response were measured. The results indicated a significant increase in the lymphocytes proliferation and the IFN-gamma prod...
Source: Cellular Immunology - August 2, 2009 Category: Allergy & Immunology Authors: Azadmehr A, Pourfathollah AA, Amirghofran Z, Hassan ZM, Moazzeni SM Tags: Cell Immunol Source Type: journals

Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we used in vivo and ex vivo fluorescence imaging to show that an antihuman vascular endothelial growth factor (VEGF) antibody represses angiogenesis and the growth of primary tumors of human fibrosarcoma HT1080 cells in implanted nude mice. Interestingly, administering the antihuman VEGF antibody reduced the development of new blood vessels and normalized pre-existing tumor vasculature in HT1080 cell tumors. In addition, antihuman VEGF antibody treatment decreased lung metastasis from the primary tumor, whereas it failed to block lung metastasis in a lung colonization experiment in which tumor cells were inj...
Source: Cancer Science - August 2, 2009 Category: Cancer & Oncology Authors: Aki Hanyu, Kiyotsugu Kojima, Kiyohiko Hatake, Kimie Nomura, Hironori Murayama, Yuichi Ishikawa, Satoshi Miyata, Masaru Ushijima, Masaaki Matsuura, Etsuro Ogata, Keiji Miyazawa, Takeshi Imamura Source Type: journals

Undifferentiated sarcoma: does it exist? A clinicopathologic study of 7 pediatric cases and review of literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Undifferentiated sarcomas are primitive mesenchymal tumors that cannot be classified among standardized histopathologic entities. Whether they represent a homogeneous group with common histogenesis and clinical behavior or comprise a variety of tumors able to differentiate along specific maturative lineages is still debated. To identify prognostic and histogenetic markers, we analyzed 7 undifferentiated sarcomas (4 in the trunk and 3 in the extremities). Mean patient age was 7.5 years, and mean follow-up was 18 months. Two clinicopathologic subtypes emerged from this study. Four primitive mesenchymal undifferentia...
Source: Human Pathology - August 2, 2009 Category: Pathology Authors: Rita Alaggio, Gianni Bisogno, Antonio Rosato, Vito Ninfo, Cheryl M. Coffin Tags: Original Contributions Source Type: journals

Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Complex chromosome rearrangements were observed on chromosome 11 in two Labrador retriever fibrosarcomas. The chromosome alterations were reflected in the loss of sequences corresponding to two tumour suppressor genes involved in cell-cycle progression. Sequencing of CDKN2B across many different breeds revealed a widespread polymorphism within the first exon of the gene, immediately before the ankyrin coding sequences. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - July 30, 2009 Category: Veterinary Research Authors: Jesus Aguirre-HernandezBruce MilneChris QueenPatricia O'BrienTess HoatherSean HauglandMalcolm Ferguson-SmithJane DobsonDavid Sargan Source Type: journals

[Fibrosarcoma simulating a benign mediastinal cystic lesion.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19646682 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - July 28, 2009 Category: Surgery Authors: García Franco CE, Tamura Ezcurra A, Aisa Ribera G, Pardo Mindan J, Torre Buxalleu W Tags: Cir Esp Source Type: journals

Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Distinct from the classic form, cellular mesoblastic nephroma is more heterogeneous in appearance on imaging, tends to be larger and present later in infancy, and can exhibit aggressive behavior including vascular encasement and metastasis. Intraspinal extension and intratumoral pseudoaneurysm are previously unreported findings encountered in our cellular mesoblastic nephroma series. The shared histopathology and translocation gene fusion support the concept of cellular mesoblastic nephroma as the renal form of IFS. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00247-009...
Source: Pediatric Radiology - July 25, 2009 Category: Radiology Tags: Pediatric Radiology Source Type: journals

Calicum microdomains form within neutrophils at the neutrophil–tumor cell synapse: role in antibody-dependent target cell apoptosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Ca2+ messages are broadly important in cellular signal transduction. In immune cells, Ca2+ signaling is an essential step in many forms of activation. Neutrophil-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) is one form of leukocyte activation that plays an important role in tumor cell killing in vitro and in patient care. Using fluorescence methodologies, we found that neutrophils exhibit Ca2+ signals during ADCC directed against breast fibrosarcoma cells. Importantly, these signals were localized to Ca2+ microdomains at the neutrophil-to-tumor cell interface where they display dynami...
Source: Cancer Immunology, Immunotherapy - July 11, 2009 Category: Cancer & Oncology Tags: Cancer Immunology, Immunotherapy Source Type: journals

Imaging of peripheral-type benzodiazepine receptor in tumor: in vitro binding and in vivo biodistribution of N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: [11C]DAC was taken up into PBR-expressing NFSa. [11C]DAC is a promising PET ligand that can be used for imaging PBR in tumor-bearing mice. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 9, 2009 Category: Radiology Authors: Tomoteru Yamasaki, Katsushi Kumata, Kazuhiko Yanamoto, Akiko Hatori, Makoto Takei, Yukio Nakamura, Sachiko Koike, Koichi Ando, Kazutoshi Suzuki, Ming-Rong Zhang Source Type: journals

Anti-tumor effects of fusion cells of type 1 dendritic cells and Meth A tumor cells using hemagglutinating virus of Japan-envelope.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It has been reported that the fusion cells of dendritic cells (DCs) and tumor cells have anti-tumor effects. In this experiment, we examined the anti-tumor effects of fusion cells of bone marrow-derived DC type 1 (DC1) and irradiated tumor cells using a newly commercially available hemagglutinating virus of Japan-envelope (HVJ-E) after cell fusion, in a mouse model. To induce DC1, bone marrow cells (BMCs) from BALB/c mice were cultured with GM-CSF, IL-12 and IFN-gamma. BMC-derived DC1 were fused with 20-Gy-irradiated Meth A cells (BALB/c-derived fibrosarcoma) using HVJ-E. We subcutaneously injected: i) the BMC-derived ...
Source: International Journal of Oncology - July 8, 2009 Category: Cancer & Oncology Authors: Yanai S, Adachi Y, Fuijisawa J, Jiang S, Okigaki M, Shi M, Shima C, Imai Y, Kwon AH, Ikehara S Tags: Int J Oncol Source Type: journals

bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions bFGF regulates, in a cell-specific manner the migration capability of fibrosarcoma cells by modulating their HA metabolism. General significance HA-metabolism as a potential therapeutic target in fibrosarcoma. PMID: 19577615 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - July 1, 2009 Category: Biochemistry Authors: Berdiaki A, Nikitovic D, Tsatsakis A, Katonis P, Karamanos NK, Tzanakakis GN Tags: Biochim Biophys Acta Source Type: journals

Paeonol Exerts Anti-angiogenic and Anti-metastatic Activities through Downmodulation of Akt Activation and Inactivation of Matrix Metalloproteinases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Paeonol (2'-hydroxy-4'-methoxyacetophenone) is known to possess anti-inflammatory and anti-proliferative activities. Recently there is evidence that anti-inflammatory agents may be useful in the setting of angiogenesis-related diseases. Thus in the present study the anti-angiogenic activity of paeonol and its mechanism were investigated in vitro and in vivo. Paeonol significantly inhibited proliferation of basic fibroblast growth factor (bFGF)-stimulated human umbilical vein endothelial cells (HUVECs). Paeonol also significantly inhibited migration and tube formation of bFGF-stimulated HUVECs in vitro. In addition, pae...
Source: Biological and Pharmaceutical Bulletin - June 30, 2009 Category: Drugs & Pharmacology Authors: Kim SA, Lee HJ, Ahn KS, Lee HJ, Lee EO, Ahn KS, Choi SH, Jung SJ, Kim JY, Baek N, Kim SH Tags: Biol Pharm Bull Source Type: journals

[Sarcomas] Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Chugh, Wathen, Maki, Benjamin, Patel, Myers, Priebat, Reinke, Thomas, Keohan, Samuels, Baker Tags: Chemotherapy, Chemotherapy Sarcomas Source Type: journals

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model [Sarcomas]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 28, 2009 Category: Cancer & Oncology Authors: Chugh, Wathen, Maki, Benjamin, Patel, Myers, Priebat, Reinke, Thomas, Keohan, Samuels, Baker Tags: Chemotherapy, Chemotherapy Sarcomas Source Type: journals

TIMP-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Both invasion-promoting MT1-MMP and its physiological inhibitorTIMP-2 play a significant role in tumorigenesis and are identified in the most aggressive cancers. Despite its antiproteolytic effects in vitro, clinical data suggest that TIMP-2 expression is positively associated with tumor recurrence, thus emphasizing the wide-ranging role of TIMP-2 in malignancies. To shed light on this role of TIMP-2, we report that low concentrations of TIMP-2, by interacting with MT1-MMP (a specific membrane receptor of TIMP-2), induce the MEK/ERK signaling cascade in fibrosarcoma HT1080 cells which express MT1-MMP naturally. TIMP-2 bind...
Source: International Journal of Cancer - June 22, 2009 Category: Cancer & Oncology Authors: Nor Eddine Sounni, Dmitri V. Rozanov, Albert G. Remacle, Vladislav S. Golubkov, Agnes Noel, Alex Y. Strongin Source Type: journals