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An assessment of feeding jejunostomy tube placement at the time of resection for gastric adenocarcinoma
ConclusionJ‐tube placement after gastrectomy for gastric cancer may be associated with increased postoperative complications with no demonstrable advantage in receiving adjuvant therapy. Routine use of J‐tubes after subtotal gastrectomy may not be justified, but may be selectively indicated in patients undergoing total gastrectomy. A prospective trial is needed to validate these results. J. Surg. Oncol © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - February 28, 2013 Category: Cancer & Oncology Authors: Sameer H. Patel, David A. Kooby, Charles A. Staley, Shishir K. Maithel Tags: Research Article Source Type: research

Adjuvant chemotherapy for gastric cancer: a randomised phase 3 trial of mitomycin-C plus either short-term doxifluridine or long-term doxifluridine plus cisplatin after curative D2 gastrectomy (AMC0201)
Oh, B K Park, H-Y Jung & B S Kim (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - February 28, 2013 Category: Cancer & Oncology Authors: Y-K KangH-M ChangJ H YookM-H RyuI ParkY J MinD Y ZangG Y KimD H YangS J JangY S ParkJ-L LeeT W KimS T OhB K ParkH-Y JungB S Kim Source Type: research

A Phase III Study of Laparoscopy-assisted Versus Open Distal Gastrectomy with Nodal Dissection for Clinical Stage IA/IB Gastric Cancer (JCOG0912)
This study followed the previous Phase II study to confirm the safety of laparoscopy-assisted distal gastrectomy (JCOG0703) and began in March 2010. A total of 920 patients will be accrued from 33 institutions within 5 years. The primary endpoint is overall survival. The secondary endpoints are relapse-free survival, proportion of laparoscopy-assisted distal gastrectomy completion, proportion of conversion to open surgery, adverse events, short-term clinical outcomes, postoperative quality of life. Only a credentialed surgeon can be responsible for both open distal gastrectomy and laparoscopy-assisted distal gastrectomy. (...
Source: Japanese Journal of Clinical Oncology - February 27, 2013 Category: Cancer & Oncology Authors: Nakamura, K., Katai, H., Mizusawa, J., Yoshikawa, T., Ando, M., Terashima, M., Ito, S., Takagi, M., Takagane, A., Ninomiya, M., Fukushima, N., Sasako, M. Tags: Clinical Trial Note Clinical Trial Notes Source Type: research

Long-Term Dietary Intake and Nutritional Deficiencies following Sleeve Gastrectomy or Roux-En-Y Gastric Bypass in a Mediterranean Population
Abstract: Background: Data on long-term dietary changes and nutritional deficiencies after sleeve gastrectomy (SG) in grade 3 obese patients are scarce. Objective: To prospectively compare dietary changes and nutritional deficiencies in grade 3 obese patients 5 years after SG and Roux-en-y gastric bypass (GBP). Participants/setting: Three hundred and fifty-five patients who had SG (n=61) or GBP (n=294) (May 2001-December 2006) at a Spanish university hospital. Design: Longitudinal, prospective, observational study. Primary outcomes/statistical analyses: Changes in energy, macronutrient, and micronutrient intake, ...
Source: Journal of the American Dietetic Association - February 26, 2013 Category: Nutrition Authors: Violeta Moizé, Alba Andreu, Lilliam Flores, Ferran Torres, Ainitze Ibarzabal, Salvadora Delgado, Antonio Lacy, Lucía Rodriguez, Josep Vidal Tags: Original Research Source Type: research

{alpha}-Synuclein pathology is related to postoperative delirium in patients undergoing gastrectomy
Conclusion: These results suggest that underlying α-synuclein pathologies in the stomach are associated with postoperative delirium, implying that postoperative delirium represents a preclinical stage of α-synuclein related to cognitive disorders. (Source: Neurology)
Source: Neurology - February 25, 2013 Category: Neurology Authors: Sunwoo, M. K., Hong, J. Y., Choi, J., Park, H. J., Kim, S. H., Lee, P. H. Tags: Parkinson's disease/Parkinsonism, Dementia with Lewy bodies, Delirium ARTICLE Source Type: research

Metabolic Effects of Bariatric Surgery in Patients With Moderate Obesity and Type 2 Diabetes: Analysis of a randomized control trial comparing surgery with intensive medical treatment.
CONCLUSIONSBariatric surgery provides durable glycemic control compared with intensive medical therapy at 2 years. Despite similar weight loss as sleeve gastrectomy, gastric bypass uniquely restores pancreatic β-cell function and reduces truncal fat, thus reversing the core defects in diabetes. PMID: 23439632 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - February 25, 2013 Category: Endocrinology Authors: Kashyap SR, Bhatt DL, Wolski K, Watanabe RM, Abdul-Ghani M, Abood B, Pothier CE, Brethauer S, Nissen S, Gupta M, Kirwan JP, Schauer PR Tags: Diabetes Care Source Type: research

Vertical Sleeve Gastrectomy is Effective in Two Genetic Mouse Models of Glucagon-like Peptide-1 Receptor Deficiency.
Abstract Glucagon-Like Peptide-1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion, and has a range of metabolic effects including enhancing insulin secretion and decreasing food intake. Post-prandial GLP-1 secretion is greatly enhanced in rats and humans following some bariatric procedures, including Vertical Sleeve Gastrectomy (VSG), and has been widely hypothesized to contribute to reduced intake, weight loss and the improvements in glucose homeostasis after VSG. We tested this hypothesis using two separate models of GLP-1 receptor deficiency. We found that VSG-operated...
Source: Diabetes - February 22, 2013 Category: Endocrinology Authors: Wilson-Pérez HE, Chambers AP, Ryan KK, Li B, Sandoval DA, Stoffers D, Drucker DJ, Pérez-Tilve D, Seeley RJ Tags: Diabetes Source Type: research

Her2/neu testing in gastric cancer: evaluating the risk of sampling errors
Conclusion Assessment of the Her2/neu status in tissue biopsies carries a significant risk of sampling errors, thereby rendering patients unsuitable for treatment with trastuzumab. (Source: Annals of Oncology)
Source: Annals of Oncology - February 16, 2013 Category: Cancer & Oncology Authors: Warneke, V. S., Behrens, H.- M., Boger, C., Becker, T., Lordick, F., Ebert, M. P. A., Rocken, C. Tags: gastrointestinal tumors Source Type: research

Should We Choose Open, Laparoscopic, or Robotic Gastrectomy?Should We Choose Open, Laparoscopic, or Robotic Gastrectomy?
Commentary on a study comparing complications after open, laparoscopic, or robotic gastrectomy, published December 2012 in British Journal of Surgery. Medscape General Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 15, 2013 Category: Consumer Health News Tags: General Surgery Viewpoint Source Type: news

A lethal cocktail: gastric perforation following liquid nitrogen ingestion - Pollard JS, Simpson JE, Bukhari MI.
We report a case of gastric perforation in an 18-year-old girl as a result of ingesting an alcoholic drink containing liquid nitrogen. The drink was purchased in licensed premises. The extent of the injury necessitated total gastrectomy with Roux-en Y reco... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 14, 2013 Category: Global & Universal Tags: Age: Adolescents Source Type: news

{alpha}-Synuclein in the Mucosa of the Human Vermiform Appendix (P03.069)
CONCLUSIONS: The lamina propria of the vermiform appendix has an abundant network of α-syn positive nerve fibres which is absent or under-developed in other GI tissues studied. Inclusions of phosphorylated Ser129 α-syn within this network suggest possible pathological involvement of the appendix. This provides the setting for further study of the initiation of α-syn aggregation in the ENS and PD pathogenesis. Given the large immune component of the vermiform appendix, this may provide support for immune-related hypotheses of PD etiology.Supported by: Ottawa Parkinson's Research Consortium.Disclosure: Dr. ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gray, M., Munoz, D., Gray, D., Woulfe, J. Tags: P03 Movement Disorders: Parkinson ' s Disease Epidemiology and Biomarkers Source Type: research

Laparoscopic Sleeve Gastrectomy and Medical Management for the Treatment of Type 2 Diabetes Mellitus in Non-Morbidly Obese Patients: A Single-Center Experience
Diabetes Technology & Therapeutics , Vol. 0, No. 0. (Source: Diabetes Technology)
Source: Diabetes Technology - February 13, 2013 Category: Endocrinology Tags: article Source Type: research

Guide to types of weight-loss surgery
Get the skinny on weight-loss surgery, including Roux-en-Y, gastric banding, sleeve gastrectomy and duodenal switch. (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - February 13, 2013 Category: Consumer Health News Source Type: news

Trends in Gastrectomy and ADH1B and ALDH2 Genotypes in Japanese Alcoholic Men and Their Gene-gastrectomy, Gene-gene and Gene-age Interactions for Risk of Alcoholism
Conclusions: The high frequency of history of gastrectomy suggested that gastrectomy is still a risk factor for alcoholism, although the percentage decreased during the period. The alcoholism-susceptibility genotype ADH1B*1/*1 was less frequent in the gastrectomy group, suggesting a competitive gene–gastrectomy interaction for alcoholism. A gene–gene interaction and gene–age interactions regarding the ADH1B genotype were observed. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 13, 2013 Category: Addiction Authors: Yokoyama, A., Yokoyama, T., Matsui, T., Mizukami, T., Kimura, M., Matsushita, S., Higuchi, S., Maruyama, K. Tags: GENETICS AND CELL BIOLOGY Source Type: research

Phase II study of preoperative chemotherapy with S‐1 and cisplatin followed by gastrectomy for clinically resectable type 4 and large type 3 gastric cancers (JCOG0210)
ConclusionsPreoperative chemotherapy with S‐1 + CDDP followed by gastrectomy is a safe and promising treatment for type 4 and large type 3 gastric cancers. Based on the results of this study, we are now conducting a phase III study (JCOG0501) to confirm the superiority of this treatment. J. Surg. Oncol © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - February 11, 2013 Category: Cancer & Oncology Authors: Yoshiaki Iwasaki, Mitsuru Sasako, Seiichiro Yamamoto, Kenichi Nakamura, Takeshi Sano, Hitoshi Katai, Toshimasa Tsujinaka, Atsushi Nashimoto, Norimasa Fukushima, Akira Tsuburaya, Tags: Research Article Source Type: research

Laparoscopy-assisted total gastrectomy with trans-orally inserted anvil (OrVil(TM)): A single institution experience.
CONCLUSION: LATG using OrVil(TM) is a technically feasible surgical procedure with sufficient lymph node dissection, less operation time and acceptable morbidity. PMID: 23431026 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2013 Category: Gastroenterology Authors: Liao GQ, Ou XW, Liu SQ, Zhang SR, Huang W Tags: World J Gastroenterol Source Type: research

Intracorporeal Laparoscopic Roux-en-Y Gastrojejunostomy After 95% Gastrectomy for Early Gastric Cancer in the Upper Third of the Stomach: A Report on 21 Cases
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - February 4, 2013 Category: Surgery Tags: article Source Type: research

Comparison of Totally Laparoscopic Total Gastrectomy and Open Total Gastrectomy for Gastric Cancer
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - February 4, 2013 Category: Surgery Tags: article Source Type: research

D2 lymphadenectomy is not only safe but necessary in the era of neoadjuvant chemotherapy
In this study, 139 patients (42 female and 97 male patients, median age 53 years) with gastric adenocarcinoma received NACT. Chemotherapy-related toxicity was noted in 32% of patients. Of the 139 patients, 129 underwent gastrectomy with D2 lymphadenectomy, with 12% morbidity and no mortality. Major pathological response of primary tumor was noted in 22 patients (17%). Of these 22 patients, lymph node metastases were noted in 12 patients. The median blood loss and lymph node yield was not significantly different to the 62 patients who underwent upfront surgery. Patients who underwent upfront surgery were older (58 vs. 52 ye...
Source: World Journal of Surgical Oncology - February 2, 2013 Category: Cancer & Oncology Authors: Shailesh ShrikhandeSavio BarretoSanjay TaloleKumar VinchurkarSomashekar AnnaiahKunal SuradkarShaesta MehtaMahesh Goel Source Type: research

Translumenal Single-Incision Laparoscopy Radical Gastrectomy with D2 Lymph Node Dissection for Early Gastric Cancer—Primary Experience with Less Invasive Surgery in China
Journal of Laparoendoscopic & Advanced Surgical Techniques Feb 2013, Vol. 23, No. 2: 141-145. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - February 1, 2013 Category: Surgery Tags: article Source Type: research

Postoperative complication rates and invasiveness of laparoscopy‐assisted distal gastrectomy and open distal gastrectomy based on the American Society of Anesthesiologists classification system
ConclusionLADG may be less invasive than ODG, even in ASA3 patients. Hence, LADG may reduce the incidence of postoperative complications in ASA1, ASA2, and ASA3 patients. (Source: Asian Journal of Endoscopic Surgery)
Source: Asian Journal of Endoscopic Surgery - February 1, 2013 Category: Surgery Authors: Hideki Kawamura, Toshiro Tanioka, Munenori Tahara, Masahiro Takahashi Tags: Original Article Source Type: research

Curative treatment for recurrent tumour implantation after ruptured hepatocellular carcinoma.
We report two cases of curative management for recurrent tumour implantation after ruptured hepatocellular carcinoma. The two patients presented with ruptured hepatocellular carcinoma and were treated with transarterial embolisation in the acute episode. Interval partial hepatectomy of the carcinoma was performed after the acute episodes. The first patient presented with a large epigastric mass 2 years after rupture. The mass was found to be adherent to the stomach and omentum. Distal gastrectomy was performed. The second patient presented with a right upper quadrant mass 4 months after rupture, and had a huge tumour attac...
Source: Hong Kong Med J - February 1, 2013 Category: Journals (General) Authors: Chow KC, Tang CN, Lai ECh, Li MK Tags: Hong Kong Med J Source Type: research

A Randomized Phase II Trial of Omentum-preserving Gastrectomy for Advanced Gastric Cancer
This randomized Phase II trial is being conducted to evaluate the impact of omentectomy for advanced gastric cancer on patient survival. The primary endpoint is the 3-year relapse-free survival rate and the secondary endpoints are 5-year overall survival, intraoperative blood loss, length of the operation and postoperative morbidity (especially postoperative ileus). The planned sample size is 250 patients (125 for complete removal of the omentum and 125 for preservation of the omentum) to determine whether omentum-preserving gastrectomy may be a candidate procedure for a Phase III trial in a randomized Phase II setting. (S...
Source: Japanese Journal of Clinical Oncology - January 30, 2013 Category: Cancer & Oncology Authors: Hasegawa, S., Yamamoto, Y., Taguri, M., Morita, S., Sato, T., Yamada, R., Oshima, T., Yukawa, N., Yoshikawa, T., Rino, Y., Imada, T., Masuda, M. Tags: Clinical Trial Note Source Type: research

Therapeutic endoscopic retrograde cholangiography using a single‐balloon enteroscope in patients with Roux‐en‐Y anastomosis
ConclusionsTherapeutic ERC using a SBE for patients with R‐Y anastomosis is considered to be safe and effective. A short SBE appears to be promising for further improvement in therapeutic results. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - January 29, 2013 Category: Gastroenterology Authors: Takashi Obana, Naotaka Fujita, Kei Ito, Yutaka Noda, Go Kobayashi, Jun Horaguchi, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Shinichi Hashimoto, Kaori Masu Tags: Original Article Source Type: research

Good Showing for Robotics in Gastric Cancer (CME/CE)
SAN FRANCISCO (MedPage Today) -- Patients with nonmetastatic gastric cancer had similar survival and other outcomes following robotic or conventional laparoscopic gastrectomy, according to a large retrospective series from Korea. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - January 25, 2013 Category: Gastroenterology Source Type: news

[A case of acute cholecystitis after colonoscopy].
Abstract A 43-year-old man, who received total gastrectomy five years ago for advanced gastric cancer, underwent a screening colonoscopy and abdominal CT scan. Abdominal CT scan revealed no abnormal findings. Colonoscopy revealed polyps at the rectum, which were removed by polypectomy. The patient did not complain of abdominal pain or discomfort throughout the procedure. But, he developed right upper quadrant abdominal pain on the next day after colonoscopy. Abdominal CT scan revealed the distended gallbladder with mild wall thickening and suspicious sandy stones or sludge in the gallbladder. The patient underwent ...
Source: Korean J Gastroenter... - January 25, 2013 Category: Gastroenterology Authors: Yun JH, Jeong WJ, Chang WS, Jo MH, Park JK, Lee SJ, Kim YD, Cheon GJ Tags: Korean J Gastroenterol Source Type: research

Recent developments in gastric endoscopic submucosal dissection: Towards the era of endoscopic resection of layers deeper than the submucosa
With technical advances in endoscopic submucosal dissection (ESD), several variations of endoscopic procedure derived from ESD and fusion procedures of endoscopy and laparoscopy for upper gastrointestinal submucosal tumor and cancer have recently been developed. The former includes endoscopic muscularis dissection (EMD), submucosal endoscopic tumor resection (SET), endoscopic submucosal tunnel dissection (ESTD) and endoscopic full‐thickness resection (EFTR), and the latter includes laparoscopic and endoscopic cooperative surgery (LECS), laparoscopy‐assisted endoscopic full‐thickness resection (LAEFR), and laparoscopi...
Source: Digestive Endoscopy - January 24, 2013 Category: Gastroenterology Authors: Nobutsugu Abe, Hirohisa Takeuchi, Atsuko Ooki, Gen Nagao, Tadahiko Masaki, Toshiyuki Mori, Masanori Sugiyama Tags: Review Source Type: research

Randomized clinical trial of enhanced recovery versus standard care after laparoscopic sleeve gastrectomy
Conclusion:The ERAS protocol in the setting of bariatric surgery shortened hospital stay and was cost‐effective. There was no increase in perioperative morbidity. Registration number: NCT01303809 (http://www.clinicaltrials.gov). Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 21, 2013 Category: Surgery Authors: D. P. Lemanu, P. P. Singh, K. Berridge, M. Burr, C. Birch, R. Babor, A. D. MacCormick, B. Arroll, A. G. Hill Tags: Randomized Clinical Trial Source Type: research

Gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation.
Abstract A case of gastric undifferentiated carcinoma with diffuse c-kit overexpression and focal neuroendocrine differentiation is described. A 76-year-old man presented appetite loss for 1 month. Gastric endoscopy showed an exophytic huge nodular mass with central ulceration at the gastric prepylorus. Distal gastrectomy was performed with lymph node dissection. Histology indicated anaplastic medium- to large-sized round tumor cells in discohesive sheets. Adenocarcinomatous areas forming tubular glands or with intracytoplasmic mucin on PAS and Alcian-blue staining were not found in any sections. Immunohistochemist...
Source: Pathology, Research and Practice - January 21, 2013 Category: Pathology Authors: Mori D, Akashi M, Baba K, Morito K, Shibaki M, Hashimoto M, Nakamura A, Mawatari S, Sato S Tags: Pathol Res Pract Source Type: research

Suitability of endoscopic submucosal dissection for treatment of submucosal gastric cancers
Conclusion:Patients with well differentiated SM1 cancer of any size and those with well differentiated SM2 cancer of 2 cm or less without lymphovascular invasion may be suitable candidates for ESD. Copyright © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. (Source: British Journal of Surgery)
Source: British Journal of Surgery - January 18, 2013 Category: Surgery Authors: I.‐S. Lee, J.‐H. Yook, Y.‐S. Park, K.‐C. Kim, S.‐T. Oh, B.‐S. Kim Tags: Original Article Source Type: research

Stable purse‐string suturing using an anterior esophagotomy for reconstruction with a circular stapler during laparoscopic total gastrectomy
ConclusionOur method of anvil insertion of a circular stapler can be a good option for safe and reliable esophagojejunostomy during a laparoscopic total gastrectomy. (Source: Asian Journal of Endoscopic Surgery)
Source: Asian Journal of Endoscopic Surgery - January 17, 2013 Category: Surgery Authors: Seong‐Ho Kong, Yunsuhk Suh, Sebastianus Kwon, Hyuk‐Joon Lee, Hyung‐Ho Kim, Han‐Kwang Yang Tags: Original Article Source Type: research

Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type.
Abstract A 60-year-old male was admitted to our hospital for gastric cancer. Considering his general condition, total gastrectomy and dissection of regional lymph nodes were performed. Macroscopically, a 45mm×20mm×10mm-sized, ulcero-infiltrative tumor located in the esophagogastric junction was described. Microscopically, the tumor consisted of a poorly differentiated adenocarcinoma intermingled with dense lymphoid infiltration predominantly composed of T-cell lymphocytes. The tumor cells infiltrated the submucosa, muscularis and subserosal layers of the stomach, respectively the esophageal adventitia. No metasta...
Source: Pathology, Research and Practice - January 14, 2013 Category: Pathology Authors: Gurzu S, Szentirmay Z, Bara T, Turcu M, Toth E, Bara T, Jung I Tags: Pathol Res Pract Source Type: research

Laparoscopy-assisted gastrectomy with D2 lymph node dissection for advanced gastric cancer without serosa invasion: a matched cohort study from South China
This study was devised to investigate the technical feasibility, safety and oncologic efficacy of laparoscopy-assisted gastrectomy for advanced gastric cancer without serosa invasion. Methods: A retrospective matched cohort study was performed in south China comparing laparoscopy-assisted gastrectomy and open gastrectomy for advanced gastric cancer without serosa invasion. Eighty-three patients with advanced gastric cancer undergoing laparoscopy-assisted gastrectomy between January 2008 and December 2010 were enrolled. These patients were compared with 83 patients with advanced gastric cancer undergoing open gastrectomy du...
Source: World Journal of Surgical Oncology - January 11, 2013 Category: Cancer & Oncology Authors: Jian-Xian LinChang-Ming HuangChao-Hui ZhengPing LiJian-Wei XieJia-bin WangLu Jun Source Type: research

Internal Hernia After Gastrectomy With Roux-Y Reconstruction for Cancer
Internal hernia (IH) after Roux-Y laparoscopic gastric bypass is well-described The incidence of IH after gastrectomy with Roux-Y reconstruction for cancer has not been well-defined. Reported rates vary from (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: K.J. Kelly, P.J. Allen, M.F. Brennan, D.G. Coit, V.E. Strong Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

Early Postoperative Oral Feeding in Gastresophageal Tumors Surgery: A Randomized Controlled Trial
With advancements in postoperative cares, attentions are now attracted toward fast recovery after surgery for upper gastrointestinal tumors. For this reason, modern postoperative care (also called Fast Track) now suggests early initiation of oral feeding in patients undergoing resection of gastroesophageal malignancies. However, evidences regarding safety and efficacy of early oral feeding (EOF) after curative gastrectomy and/or esophagectomy are scarce. Moreover, there is not sufficient randomized clinical trial (RCT) regarding this issue. Hence, we conducted the present RCT to investigate clinical outcomes of EOF in pati...
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: S. Shoar, H. Mahmoodzadeh, N. Hosseini Araghi, N. Mahboobi, F. Sirati, Z. Khorgami Source Type: research

The Incidence of Cholecystectomy After Sleeve Gastrectomy Versus Gastric Bypass
(Source: Journal of Surgical Research)
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: V.B. Tsirline, R.C. Phillips, Z.M. Keilani, T.S. Kuwada, K. Gersin, D. Stefanidis Tags: Quickshot Session: Tuesday 2/5 7:30 AM to 9:30 AM Source Type: research

The Churg-Strauss Syndrome: Diagnosed for the First Time in a Gastrectomy Specimen.
We report on a 47-year-old male patient, in whom the diagnosis of CSS was finally established for the first time on the basis of the histological work-up of a gastrectomy specimen. Endoscopic inspection had revealed a rigid gastric wall and a large irregularly shaped ulcer in the prepyloric antrum. Despite the fact that no carcinoma was demonstrable in the biopsy material, a gastrectomy was nevertheless performed since the endoscopic appearance was strongly suspicious for a carcinoma. The gastrectomy specimen revealed massive eosinophilic gastritis in combination with granulomas and necrotising vasculitis - localised mainl...
Source: Zeitschrift fur Gastroenterologie - January 9, 2013 Category: Gastroenterology Authors: Stolte M, Jatzwauk P, Bethke B Tags: Z Gastroenterol Source Type: research

D2 lymphadenectomy can disseminate tumor cells into peritoneal cavity in patients with advanced gastric cancer.
Abstract We sought to determine the dissemination of gastric cancer cells before and after radical D2 surgery and to determine the effectiveness of EIPL in preventing post-operative peritoneal metastasis. 64 patients were recruited with advanced gastric cancer for our final analysis. Complete curative gastrectomy with D2 lymphadenectomy was performed on the 64 patients. Before surgery, peritoneal lavage fluid was collected for cytological analysis by cell smearing and immunohistochemistry to detect disseminated cancer cells (S1). Following tumor and lymph node resection, peritoneal lavage fluid was collected for cy...
Source: Neoplasma - January 7, 2013 Category: Cancer & Oncology Authors: Yu XF, Ren ZG, Xue YW, Song HT, Wei YZ, Li CM Tags: Neoplasma Source Type: research

Clinicopathological characteristics and optimal management for esophagogastric junctional cancer; a single center retrospective cohort study
Conclusions: We should distinguish type Ge tumor from type E (AD) tumor because of the clinicopathological and prognostic differentiation. Extended gastrectomy with or without lower esophagectomy according to tumor location and lower mediastinal and abdominal lymphadenectomy are recommended for EGJ cancer.Trial registration: University Hospital Medical Information Network in Japan, UMIN000008596. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - January 7, 2013 Category: Cancer & Oncology Authors: Hiroaki ItoHaruhiro InoueNoriko OdakaHitoshi SatodateMichitaka SuzukiShumpei MukaiYusuke TakeharaHiroyuki KidaShin-ei Kudo Source Type: research

Total gastrectomy in an elderly patient complicated by esophageal fistula: rescue by the over-the-scope clip
A 78-year-old woman was hospitalized with melena. EGD revealed an ulcerated lesion on the lesser gastric curvature measuring 2 cm. Biopsy specimens revealed carcinomatous lymphangitis and neoplastic cell nests immunoreactive for CDX2, and cytokeratins 7 and 20. A CT scan of the chest, abdomen, and pelvis did not show metastasis, and a total gastrectomy with an esophagojejunal roux-en-Y anastomosis was performed. She experienced sepsis on the fifth postoperative day. Methylene blue, administered orally to define suspected dehiscence of the esophagojejunal anastomosis, was detected in the abdominal drains. A CT scan revealed...
Source: Gastrointestinal Endoscopy - January 7, 2013 Category: Gastroenterology Authors: Carlos Noronha Ferreira, Luis Carrilho Ribeiro, José Velosa, José Ferreira, Carlos Ferreira, José Paulo Freire, Jorge Marques, António Ruivo, Henrique Bicha Castelo Tags: At the Focal Point Source Type: research

Lipid peroxidation-induced DNA adducts in human gastric mucosa
In this report, we applied an adductome approach to gastric mucosa samples taken at the time of a gastrectomy for gastric cancer in Lujiang, China, and in Hamamatsu, Japan. Seven lipid peroxidation-related DNA adducts [1,N6-etheno-2'-deoxyadenosine, butanone-etheno-2'-deoxycytidine (BdC), butanone-etheno-2'-deoxy-5-methylcytidine, butanone-etheno-2'-deoxyadenosine (BdA), heptanone-etheno-2'-deoxycytidine, heptanone-etheno-2'-deoxyadenosine (HdA) and heptanone-etheno- 2'-deoxyguanosine] were identified in a total of 22 gastric mucosa samples. The levels of these adducts ranged from 0 to 30 000 per 109 bases. Although the pr...
Source: Carcinogenesis - January 2, 2013 Category: Cancer & Oncology Authors: Matsuda, T., Tao, H., Goto, M., Yamada, H., Suzuki, M., Wu, Y., Xiao, N., He, Q., Guo, W., Cai, Z., Kurabe, N., Ishino, K., Matsushima, Y., Shinmura, K., Konno, H., Maekawa, M., Wang, Y., Sugimura, H. Tags: Original Manuscript Source Type: research

The prognosis of gastric cancer patients with marginally elevated carcinoembryonic antigen (CEA) values after D2 radical gastrectomy
ConclusionOur study showed that patients with normal postoperative CEA levels have a better prognosis. Furthermore, for marginally elevated postoperative CEA level gastric cancer patients, the tumor position and histological grade were two important factors for predicting the prognosis and the need for aggressive therapy. J. Surg. Oncol © 2013 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - January 1, 2013 Category: Cancer & Oncology Authors: Shi Chen, Xing‐Yu Feng, Yuan‐Fang Li, Bai‐Wei Zhao, Zhi‐Wei Zhou, Ying‐Bo Chen Tags: Research Article Source Type: research

Management of localized gastric cancer
Abstract Gastric cancer continues to be a fatal disease with majority of cases presenting in late stages. For patients with advanced disease, we can only recommend palliative therapy. For localized gastric cancer, the approaches vary in various regions of the world. In western countries, preoperative chemotherapy or adjuvant chemo‐radiation is preferred; however in Asia, surgery followed by adjuvant chemotherapy is favored. The extent of the lymph node dissection also varies by region. D2 gastrectomy is difficult to implement in most western countries while it is standardized and is a routine in Asia. We recommend multid...
Source: Journal of Surgical Oncology - January 1, 2013 Category: Cancer & Oncology Authors: Mariela A. Blum, Taketa Takashi, Akihiro Suzuki, Jaffer A. Ajani Tags: Review Article Source Type: research

Bariatric surgery in Singapore from 2005 to 2009.
CONCLUSION: There is a flux of newer procedures in Singapore. Adjustable gastric banding, which was the only available procedure being performed in 2004, was gradually being replaced by other procedures such as sleeve gastrectomy and Roux-en-Y gastric bypass in 2009. PMID: 23270823 [PubMed - in process] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - January 1, 2013 Category: Surgery Authors: Goel R, Agarwal A, Shabbir A, So JB, Pasupathy S, Wong A, Cheng A, Lomanto D Tags: Asian J Surg Source Type: research

Stapler's malfunction during laparoscopic sleeve gastrectomy: an unusual but correctable complication.
PMID: 23357103 [PubMed - in process] (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - January 1, 2013 Category: Surgery Authors: Elgeidie A, Gadel Hak N, Abdulla T Tags: Surg Obes Relat Dis Source Type: research

Bariatric Surgery to Treat Obesity
Summary: Obesity has become a global health problem that contributes to numerous life-threatening and disabling diseases, such as type 2 diabetes mellitus and coronary artery disease. The long-term results of traditional weight loss therapies, including diet, exercise, and medications, are relatively poor. Bariatric surgery is the most effective treatment of morbidly obese patients to allow substantial, sustained weight loss and to improve or resolve obesity-associated comorbidities, thereby reducing mortality. According to US practice guidelines, patients qualify for bariatric surgery with a body mass index of 35 kg/m2 a...
Source: Seminars in Nephrology - January 1, 2013 Category: Urology & Nephrology Authors: Hermann J. Kissler, Utz Settmacher Tags: Gunter Wolf, MD, MHBA Source Type: research

A Phase II Clinical Trial of Endoscopic Submucosal Dissection for Early Gastric Cancer of Undifferentiated Type: Japan Clinical Oncology Group Study JCOG1009/1010
A Phase II clinical trial has been initiated to evaluate the efficacy and safety of endoscopic submucosal dissection for intramucosal (cT1a) gastric cancer of undifferentiated type. Patients with cT1a gastric cancer with undifferentiated-type adenocarcinoma are eligible for the study. The tumor size should be 2 cm or less without ulceration. The study will enroll a total of 325 patients from 51 institutions over a 4-year period. The primary endpoint is proportion of 5-year overall survival (% 5-year overall survival) in patients with undifferentiated dominant type. The secondary endpoints are overall survival, relapse-free...
Source: Japanese Journal of Clinical Oncology - December 26, 2012 Category: Cancer & Oncology Authors: Takizawa, K., Takashima, A., Kimura, A., Mizusawa, J., Hasuike, N., Ono, H., Terashima, M., Muto, M., Boku, N., Sasako, M., Fukuda, H., for the Gastrointestinal Endoscopy Study Group (GIESG) and Stomach Cancer Study Group (SCSG) of the Japan Clinical Onco Tags: Clinical Trial Note, Original Articles Clinical Trial Notes Source Type: research

Comparison of Totally Laparoscopic Total Gastrectomy and Laparoscopic-Assisted Total Gastrectomy Methods for the Surgical Treatment of Early Gastric Cancer Near the Gastroesophageal Junction
Journal of Laparoendoscopic & Advanced Surgical Techniques , Vol. 0, No. 0. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - December 20, 2012 Category: Surgery Tags: article Source Type: research

[Perioperative oxygen administration : Prevention of anastomotic leakage after gastrectomy.]
[Perioperative oxygen administration : Prevention of anastomotic leakage after gastrectomy.] Chirurg. 2012 Dec 19; Authors: Franzke T, Jähne J PMID: 23247561 [PubMed - as supplied by publisher] (Source: Der Chirurg)
Source: Der Chirurg - December 19, 2012 Category: Surgery Authors: Franzke T, Jähne J Tags: Chirurg Source Type: research

Improved techniques for double-balloon-enteroscopy-assisted endoscopic retrograde cholangiopancreatography.
CONCLUSION: Short-type DBE combined with several technical innovations enabled us to perform ERCP in most patients with altered gastrointestinal anatomy. PMID: 23239923 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 14, 2012 Category: Gastroenterology Authors: Osoegawa T, Motomura Y, Akahoshi K, Higuchi N, Tanaka Y, Hisano T, Itaba S, Gibo J, Yamada M, Kubokawa M, Sumida Y, Akiho H, Ihara E, Nakamura K Tags: World J Gastroenterol Source Type: research