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This page shows you the latest news and research items in this category.

Evaluation of a Newly Developed Rapid Stool Antigen Test Using an Immunochromatographic Assay To Detect Helicobacter pylori.
Abstract The ASAN Easy Test H. pylori is a newly developed rapid test for Helicobacter pylori that uses a stool antigen immunochromatographic assay (S-ICT). The aim of this study was to evaluate this kit for the diagnosis of H. pylori under various histological conditions. We enrolled 266 consecutive patients undergoing a routine health checkup and endoscopy with biopsy. H. pylori infection was confirmed if at least 2 out of the 3 following tests were positive: histology, real-time polymerase chain reaction (PCR), and the stool antigen test by enzyme immunoassay (S-EIA). Histological examination was performed using...
Source: Japanese Journal of Infectious Diseases - March 1, 2013 Category: Infectious Diseases Authors: Jekarl DW, An YJ, Lee S, Lee J, Kim Y, Park YJ, Kim TJ, Kim JI, Park SH Tags: Jpn J Infect Dis Source Type: research

Prevalence and characteristics of nodular gastritis in Japanese elderly
ConclusionNG in the elderly was also suggested to be a risk factor for gastric cancer as well as in the young. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 22, 2013 Category: Gastroenterology Authors: Shinji Kitamura, Mitsugi Yasuda, Naoki Muguruma, Koichi Okamoto, Hisashi Takeuchi, Yoshimi Bando, Hiroshi Miyamoto, Toshiya Okahisa, Mitsuyasu Yano, Ryusuke Torisu, Tetsuji Takayama Tags: Clinical Gastroenterology Source Type: research

Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India.
Conclusion: There is high H Pylori positivity rate in patients of functional dyspepsia. The eradication of H Pylori does not resolve the symptoms, despite healing of gastritis. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 22, 2013 Category: Gastroenterology Authors: Jaswinder Singh Sodhi, Gul Javid, Showkat Ali Zargar, Syed Tufail, Altaf Shah, BA Khan, GN Yattoo, GM Gulzar, MA Khan, MI Lone, Riyaz u Saif, Shaheena Parveen, Abid Shoukat Tags: Clinical Gastroenterology Source Type: research

Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer
Background: The determination of sensitive chemotherapy drugs for gastric cancer (GC) is one of thegreatest challenges of adjuvant therapy. Here we evaluated the chemosensitivity of GC toanticancer drugs and the telomerase reverse transcriptase (hTERT) mRNA expression, andinvestigated the relationship of them. Methods: The GC cells which were collected from 68 patients with primary GC were primary cultured.The chemosensitivity of GC cells to anticancer drugs was evaluated successfully using theMTT assay for 60 cases of GC cells, and the hTERT mRNA expression was examined in 60cases of GC tissues and corresponding normal ga...
Source: Diagnostic Pathology - February 22, 2013 Category: Pathology Authors: Lin WangPei-Feng LiMing GengYong-Cheng CaoYing-Chun Yin Source Type: research

Low rate of recurrence of Helicobacter Pylori infection in spite of high clarithromycin resistance in Pakistan
Conclusion: A low rate of recurrence of H. pylori infection was found in patients with dyspeptic symptoms. H. pylori isolates demonstrated a high invitro clarithromycin resistance. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - February 21, 2013 Category: Gastroenterology Authors: Javed YakoobShahab AbidWasim JafriZaigham AbbasKhalid MumtazSaeed HamidRashida Ahmed Source Type: research

Interleukin‐21 and TNF‐α are critical for the development of autoimmune gastritis in mice
ConclusionsThese data reveal the essential role of IL‐21 in the development of AIG and suggest that in addition to corticosteroids, anti‐TNF‐α as well as anti‐IL‐21 have the potential to induce remission of AIG, offering additional therapeutic options for AIG patients. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 21, 2013 Category: Gastroenterology Authors: Hisayo Nishiura, Satoru Iwamoto, Masahiro Kido, Nobuhiro Aoki, Ryutaro Maruoka, Aki Ikeda, Tsutomu Chiba, Norihiko Watanabe Tags: Experimental Gastroenterology Source Type: research

Toxic effects of chromium on tannery workers at Sialkot (Pakistan)
Chromium is widely used in the leather industry, and tannery workers are under constant threat of adverse health effects due to its excessive exposure. Our objective was to find out the toxic effects of chromium on tannery workers at Sialkot, Pakistan. A total of 240 males consisting of 120 workers from tanneries at Sialkot and equal number of controls were included. Blood complete counts, high-sensitive C-reactive protein, malondialdehyde and routine biochemical tests were carried out by routine procedures. Chromium levels in blood (BCr) and urine were analyzed using graphite furnace atomic absorption spectrophotometer Pe...
Source: Toxicology and Industrial Health current issue - February 20, 2013 Category: Toxicology Authors: Khan, D. A., Mushtaq, S., Khan, F. A., Khan, M. Q. A. Tags: Articles Source Type: research

Pathogenic T cells persist after reversal of autoimmune disease by immunosuppression with regulatory T cells
In this study we demonstrate that a single dose of in vitro‐induced Treg cells (iTreg cells) resulted in the functional repair and restitution of stomach tissue that had been severely damaged in advanced autoimmune gastritis. iTreg cells caused depletion or inactivation of autoreactive naïve T cells that were antigen inexperienced, however, autoreactive effector/memory T cells persisted in treated mice, resulting in residual cellular infiltrates within the repaired stomach tissue. The persisting autoreactive T cells were able to rapidly cause autoimmune disease if iTreg cells were removed. Similar data were obtained fro...
Source: European Journal of Immunology - February 19, 2013 Category: Allergy & Immunology Authors: Eric Tu, Dorothée Bourges, Paul A. Gleeson, Desmond K.Y. Ang, Ian R. Driel Tags: Regular Article Source Type: research

Salivary IgG assay to detect Helicobacter pylori infection in an Indian adult population
Conclusion: EIAgen H. pylori IgG assay is a noninvasive, moderately accurate, and sensitive method for the detection of H. pylori infection in saliva. Salivary anti H. pylori IgG test prior to endoscopy is a useful screening test for seroepidemiological studies. (Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3))
Source: Table of Contents : Indian Journal of Dental Research : 2006 - 17(3) - February 19, 2013 Category: Dentistry Authors: Ramya Thirumala KrishnaswamyChaya Manoranjini DavidSavitha GovindaiahRamnarayan Belur KrishnaprasadSanjay Chikkarasinakere Jogigowda Source Type: research

Pathogenic T cells persist after reversal of autoimmune disease by immunosuppression with regulatory T cells.
In this study we demonstrate that a single dose of in vitro-induced Treg cells (iTreg cells) resulted in the functional repair and restitution of stomach tissue that had been severely damaged in advanced autoimmune gastritis. iTreg cells caused depletion or inactivation of autoreactive naïve T cells that were antigen inexperienced, however, autoreactive effector/memory T cells persisted in treated mice, resulting in residual cellular infiltrates within the repaired stomach tissue. The persisting autoreactive T cells were able to rapidly cause autoimmune disease if iTreg cells were removed. Similar data were obtained from ...
Source: European Journal of Immunology - February 19, 2013 Category: Allergy & Immunology Authors: Tu E, Bourges D, Gleeson PA, Ang DK, van Driel IR Tags: Eur J Immunol Source Type: research

Apical MUC1 expression revealed on the foveolar epithelium in H. pylori gastritis
& D M Swallow (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: M RashidA S TeixeiraU QureshiS P PereiraM R NovelliD M Swallow Source Type: research

Phase 2 BOLD Extension Study Safety Results for Siponimod (BAF312) in Patients with Relapsing-Remitting Multiple Sclerosis (P01.176)
CONCLUSIONS: Siponimod was well tolerated during the first 12 months of extension, in line with the core trial, and no new safety signals were observed.Supported by: Novartis Pharma AG.Disclosure: Dr. Hartung has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Sanofi-Aventis Pharmaceuticals, Inc., Bayer, Novartis, and Merck Serono. Dr. Selmaj has received personal compensation for activities with Biogen Idec, Genzyme, Ono Pharmaceutical, Novartis, Bayer, Hoffmann LaRoche, Merck, Serono and Synthon. Dr. Li has received personal compensation for activities with Genzyme, Novartis, and Nuron ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hartung, H.-P., Selmaj, K., Li, D., Hemmer, B., Freedman, M., Stuve, O., Rieckmann, P., Montalban, X., Ziemssen, T., Zhang-Auberson, L., Hunter, B., Rochotte, E., Wallstrom, E., Kappos, L. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Helicobacter pylori eradication and reflux disease onset: Did gastric acid get "crazy"?
Abstract Gastroesophageal reflux disease (GORD) is highly prevalent in the general population. In the last decade, a potential relationship between Helicobacter pylori (H. pylori) eradication and GORD onset has been claimed. The main putative mechanism is the gastric acid hypersecretion that develops after bacterial cure in those patients with corpus-predominant gastritis. We performed a critical reappraisal of the intricate pathogenesis and clinical data available in this field. Oesophagitis onset after H. pylori eradication in duodenal ulcer patients has been ascribed to a gastric acid hypersecretion, which could...
Source: World Journal of Gastroenterology : WJG - February 14, 2013 Category: Gastroenterology Authors: Zullo A, Hassan C, Repici A, Bruzzese V Tags: World J Gastroenterol Source Type: research

Association of two ERCC4 tagSNPs with susceptibility to atrophic gastritis and gastric cancer in Chinese.
Abstract Genetic polymorphisms in excision repair cross-complementing group 4 (ERCC4) may contribute to the risk of cancer development. However, there are few reports regarding to susceptibility to gastric cancer (GC) or its precursor, atrophic gastritis (AG). Thereby, we investigated the association between two tag single nucleotide polymorphisms (tagSNPs) rs6498486 and rs254942, which represents the majority of common SNPs of ERCC4 gene, and the risks of GC and AG development in a sex- and age-matched case-control designed study. We found that rs6498486 polymorphism was associated with a reduced AG risk in total ...
Source: Gene - February 12, 2013 Category: Genetics & Stem Cells Authors: Gong Y, He C, Duan Z, Sun L, Xu Q, Xing C, Yuan Y Tags: Gene Source Type: research

Identification of Novel Drug Targets in Hpb38, Hpp12, Hpg27, Hpshi470, Hpsjm180 Strains of Helicobacter Pylori: An In Silico Approach for Therapeutic Intervention.
Abstract Helicobacter species colonizes the stomach and are associated with the development of gastritis disease. Drugs for treatment of Helicobacter infection relieve pain or gastritis symptoms but they are not targeted specifically to Helicobacter pylori. Therefore, there is dire need for discovery of new drug targets and drugs for the treatment of H. pylori. The main objective of this study is to screen the potential drug targets by in silico analysis for the potent strains of H. pylori which include HpB38, HpP12, HpG27, Hpshi470 and HpSJM180. Genome and metabolic pathways of pathogen H. pylori and the host Homo...
Source: Current Drug Targets - February 11, 2013 Category: Drugs & Pharmacology Authors: Reddy NR, Pavani T Tags: Curr Drug Targets Source Type: research

'Bad' Gut Bacteria May Help Control Diabetes
A stomach bacterium believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach's ecosystem and controlling body weight and glucose tolerance, according to immunologists at the Virginia Bioinformatics Institute of Virginia Tech. Usually the villain in studies of gastric cancer and peptic ulcers, Helicobacter pylori infect about half of the world's population although most infected individuals don't get sick. The bacterium's dwindling numbers coincide with the epidemic of obesity and diabetes in developed countries. "H... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 10, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

Villain stomach bug may have a sweet side
(Virginia Tech) A stomach bacterium believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach's ecosystem and controlling body weight and glucose tolerance, according to immunologists at the Virginia Bioinformatics Institute of Virginia Tech. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 8, 2013 Category: Global & Universal Source Type: news

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.
We report 2 families with heterozygous GIF mutation, 290T>C, M97T, with decreased binding affinity of GIF for vitamin B12 and one family with heterozygous GIF mutation 435_437delGAA, K145_N146delinsN and no B12 binding activity of mutated GIF. All cases with vitamin B12 deficit carried the FUT2 rs601338 secretor variant. Ulex europeus binding to GIF was influenced by FUT2 genotypes and GIF concentration was lower, in gastric juice from control subjects with the secretor genotype. GIF290C allele was reported in 5 European cases and no Africans among 1282 ambulatory subjects and was associated with low plasma vitamin B12 ...
Source: Biochimie - February 8, 2013 Category: Biochemistry Authors: Chery C, Hehn A, Mrabet N, Oussalah A, Jeannesson E, Besseau C, Alberto JM, Gross I, Josse T, Gérard P, Guéant-Rodriguez RM, Freund JN, Devignes J, Bourgaud F, Peyrin-Biroulet L, Feillet F, Guéant JL Tags: Biochimie Source Type: research

Association Between Helicobacter pylori Infection Detected by the 13C‐Urea Breath Test and Low Serum Ferritin Levels among Japanese Adults
ConclusionThis study showed that H. pylori infection was significantly associated with altered serum ferritin levels in Japanese individuals, particularly in those aged ≥50 years. (Source: Helicobacter)
Source: Helicobacter - February 1, 2013 Category: Gastroenterology Authors: Hiroko Nakagawa, Takashi Tamura, Yoko Mitsuda, Mio Kurata, Yasuyuki Goto, Yoshikazu Kamiya, Takaaki Kondo, Nobuyuki Hamajima Tags: Original Article Source Type: research

Peptic ulceration, Helicobacter Pylori seropositivity and Chronic Obstructive Pulmonary Disease
ConclusionsOur findings suggest a relationship between peptic ulcer disease and COPD that is more that just a shared susceptibility to different environmental stimuli. (Source: Respirology)
Source: Respirology - February 1, 2013 Category: Respiratory Medicine Authors: R Siva, S S Birring, M Berry, A Rowbottom, I D Pavord Tags: Original Article Source Type: research

Protein kinase C isozymes regulate matrix metalloproteinase-1 expression and cell invasion in Helicobacter pylori infection
Conclusion The targeting of certain PKC isozymes might represent a suitable strategy to interfere with the MMP-1-dependent remodelling of infected tissue and to overcome the invasive behaviour of gastric cancer cells. (Source: Gut)
Source: Gut - January 31, 2013 Category: Gastroenterology Authors: Sokolova, O., Vieth, M., Naumann, M. Tags: Ulcer, Campylobacter, Salmonella, Shigella, Escherichia coli, Helicobacter pylori, Open access, Stomach and duodenum, Pancreatic cancer Source Type: research

High Proportion of Granzyme B+ Intraepithelial Lymphocytes Contributes to Epithelial Apoptosis in Helicobacter pylori‐Associated Lymphocytic Gastritis
ConclusionsThis study shows that in addition to the numerical increase in the IELs, there are significant changes in the subpopulations and cytotoxicity of IELs between HPG and H. pylori‐associated LG. In particular, enhanced GrB‐associated cytotoxicity of the IELs in H. pylori‐associated LG contributes to an increase in epithelial apoptosis. (Source: Helicobacter)
Source: Helicobacter - January 30, 2013 Category: Gastroenterology Authors: Song‐Hee Han, Mee Joo, Kyoung‐Mee Kim Tags: Original Article Source Type: research

A novel approach for the detection of early gastric cancer: Fluorescence spectrum of gastric juice
ConclusionEnhancement of P1FI of gastric juice occurs in the early stage of gastric cancer. Fluorescence spectrum of gastric juice may be used as a novel screening tool for early detection of gastric cancer. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - January 29, 2013 Category: Gastroenterology Authors: Kai Deng, Li Ya Zhou, San Ren Lin, Yuan Li, Mo Chen, Qiu Ming Geng, Yu Wen Li Tags: Original Article Source Type: research

Diagnosis of Helicobacter pylori infection in gastric mucosa by endoscopic features: A multicenter prospective study
ConclusionIt is suggested that endoscopic diagnosis of H. pylori infection in gastric mucosa by conventional endoscopy and the IC method is mostly possible. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - January 29, 2013 Category: Gastroenterology Authors: Takahiro Kato, Nobuaki Yagi, Tomoari Kamada, Takuro Shimbo, Hidenobu Watanabe, Kazunori Ida, Tags: Original Article Source Type: research

Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: A multicenter study of 2283 cases
ConclusionHigh concentrations of bile acid seem to be associated with an elevated risk of intestinal metaplasia. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - January 29, 2013 Category: Gastroenterology Authors: Takeshi Matsuhisa, Tetsuo Arakawa, Tetsuo Watanabe, Tadashi Tokutomi, Kouichi Sakurai, Seisuke Okamura, Shinji Chono, Tomoari Kamada, Atsushi Sugiyama, Yoshinori Fujimura, Kenji Matsuzawa, Masanori Ito, Mitsugu Yasuda, Hiroyoshi Ota, Ken Haruma Tags: Original Article Source Type: research

Protective effect of silymarin against ethanol-induced gastritis in rats: Role of sulfhydryls, nitric oxide and gastric sensory afferents.
In this study, we examined the effect of silymarin on gastritis in rats. Oral administration of silymarin dose-dependently decreased gastric lesions in ethanol-induced gastritis model. Silymarin also significantly suppressed the development of gastric lesions in aspirin- or water immersion-restraint stress-induced gastritis models. Further study demonstrated that the gastroprotective effect of silymarin was blocked by nitric oxide (NO) synthase inhibitor l-NAME, SH blocker N-ethylmaleimide or TRPV1 antagonist capsazepine in ethanol-induced gastritis model. In addition, ex vivo analysis revealed that ethanol-induced decreas...
Source: Food and Chemical Toxicology - January 26, 2013 Category: Food Science Authors: Shin JH, Lee CW, Oh SJ, Yun J, Lee K, Park SK, Kim HM, Han SB, Kim Y, Kim HC, Kang JS Tags: Food Chem Toxicol Source Type: research

How to use Helicobacter pylori testing in paediatric practice
Introduction Helicobacter pylori is a slowly growing, gram negative microaerophilic bacterium that colonises the gastric mucosa. Cross-sectional epidemiological studies from both developed and developing countries suggest that the prevalence of H. pylori infection worldwide is declining, and may even be less than 10% in ‘westernised’ countries.1 2 H. pylori infection is acquired during the first decade of life and infection usually persists without treatment. Spontaneous clearance has been reported, although co-incidental antibiotic exposure may influence such ‘clearance’. H. pylori is the causative...
Source: Archives of Disease in Childhood - Education and Practice - January 16, 2013 Category: Pediatrics Authors: Crowley, E., Bourke, B., Hussey, S. Tags: Oncology, Surgery, Stomach and duodenum, Immunology (including allergy), Drugs: infectious diseases, Pain (neurology), Childhood nutrition, Childhood nutrition (paediatrics), Surgical diagnostic tests, Screening (epidemiology), Screening (public health) Source Type: research

Varicella gastritis in an immunocompetent child
Abstract: The varicella zoster virus (VZV) is a very rare cause of gastritis. Gastritis caused by VZV can be presented as abdominal pain, vomiting. Most of the cases reported with varicella gastritis in the literature are immunocompromised patients with various kinds of malignancy, and most of these patients are adults. Here we report an adolescent girl with acute abdominal pain. The girl was immunocompetent. Her endoscopically taken biopsy material revealed varicella, and her gastritis was healed with acyclovir therapy. This is a very rare condition and not frequently reported in the literature. The authors want to drive ...
Source: Journal of Clinical Virology - January 15, 2013 Category: Virology Authors: Meltem Ugras, Ayca Vitrinel, Gulden Yilmaz, Kenan Midilli, Ferda Ozkan Tags: Full length articles Source Type: research

Risk of advanced gastric precancerous lesions in Helicobacter pylori infected subjects is influenced by ABO blood group and cagA status
Abstract A higher incidence of stomach cancer in ABO blood type A individuals than in those with blood type O has been known for a long time. We studied this association in relation to Helicobacter pylori (Hp) of different cagA status. For this study we used baseline gastric histopathology data and DNAs from frozen gastric biopsies of 2077 subjects enrolled in a chemoprevention trial for gastric precancerous lesions in Venezuela. We analyzed 6 single nucleotide polymorphisms in the ABO gene and we assessed the presence of the Hp cagA gene. Odds ratios for risk of advanced precancerous gastric lesions were calculated using ...
Source: International Journal of Cancer - January 15, 2013 Category: Cancer & Oncology Authors: Cosmeri Rizzato, Ikuko Kato, Martyn Plummer, Nubia Muñoz, Angelika Stein, Leen Jan van Doorn, Silvia Franceschi, Federico Canzian Tags: Cancer Genetics Source Type: research

AIRP Best Cases in Radiologic-Pathologic Correlation: Gastritis Cystica Polyposa [AIRP/AFIP Archives]
(Source: Radiographics recent issues)
Source: Radiographics recent issues - January 15, 2013 Category: Radiology Authors: Kalra, V. B., Gilbert, J. W., Mitchell, K. A., Salem, R. R., Israel, G. M. Tags: Gastrointestinal Radiology AIRP/AFIP Archives Source Type: research

The guggulsterone derivative GG-52 inhibits NF-{kappa}B signaling in gastric epithelial cells and ameliorates ethanol-induced gastric mucosal lesions in mice
Gastric mucosal inflammation can develop after challenge with noxious stimuli such as alcohol. Specially, alcohol stimulates the release of inflammatory cytokines but does not increase gastric acid secretion, leading to gastric mucosal damage. The plant sterol guggulsterone and its novel derivative GG-52 have been reported to inhibit nuclear factor-B (NF-B) signaling in intestinal epithelial cells and experimental colitis. In the present study, we investigated the anti-inflammatory effects of GG-52 on gastric epithelial cells and on ethanol-induced gastric mucosal inflammation in mice. GG-52 inhibited the expression of int...
Source: AJP: Gastrointestinal and Liver Physiology - January 15, 2013 Category: Gastroenterology Authors: Kim, J. M., Kim, S. H., Ko, S. H., Jung, J., Chun, J., Kim, N., Jung, H. C., Kim, J. S. Tags: INFLAMMATION/IMMUNITY/MEDIATORS Source Type: research

Evaluation of a new fluorescence quantitative PCR test for diagnosing Helicobacter pylori infection in children
Background: Numerous diagnostic tests are available to detect Helicobactor pylori (H. pylori). There has been no single test available to detect H. pylori infection reliably. We evaluated the accuracy of a new fluorescence quantitative PCR (fqPCR) for H. pylori detection in children. Methods: Gastric biopsy specimens from 138 children with gastritis were sent for routine histology exam, rapid urease test (RUT) and fqPCR. 13C-urea breath test (13C-UBT) was carried out prior to endoscopic procedure. Gastric fluids and dental plaques were also collected for fqPCR analysis. Results: 38 children (27.5%) were considered positive...
Source: BMC Gastroenterology - January 14, 2013 Category: Gastroenterology Authors: Zhiying OuLiya XiongDing-You LiLanlan GengLixia LiPeiyu ChenMin YangYongmei ZengZhenwen ZhouHuimin XiaSitang Gong Source Type: research

The Churg-Strauss Syndrome: Diagnosed for the First Time in a Gastrectomy Specimen.
We report on a 47-year-old male patient, in whom the diagnosis of CSS was finally established for the first time on the basis of the histological work-up of a gastrectomy specimen. Endoscopic inspection had revealed a rigid gastric wall and a large irregularly shaped ulcer in the prepyloric antrum. Despite the fact that no carcinoma was demonstrable in the biopsy material, a gastrectomy was nevertheless performed since the endoscopic appearance was strongly suspicious for a carcinoma. The gastrectomy specimen revealed massive eosinophilic gastritis in combination with granulomas and necrotising vasculitis - localised mainl...
Source: Zeitschrift fur Gastroenterologie - January 9, 2013 Category: Gastroenterology Authors: Stolte M, Jatzwauk P, Bethke B Tags: Z Gastroenterol Source Type: research

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
Conclusion Activation of the SDF-1/CXCR4 axis can contribute to early stages of carcinogenesis primarily through recruitment of stromal cells and modulation of the progenitor niche. (Source: Gut)
Source: Gut - January 4, 2013 Category: Gastroenterology Authors: Shibata, W., Ariyama, H., Westphalen, C. B., Worthley, D. L., Muthupalani, S., Asfaha, S., Dubeykovskaya, Z., Quante, M., Fox, J. G., Wang, T. C. Tags: Editor's choice, Stomach and duodenum, Pancreatic cancer Source Type: research

IgG2 response and low IgG titre specific to Helicobacter pylori's CagA as serologic markers for gastric cancer.
Abstract Infection with Helicobacter pylori cytotoxin-associated gene A (CagA) positive strains is associated with the development of gastric cancer. However, some reports have failed to demonstrate an increased frequency of CagA antibodies in gastric cancer patients. We evaluated the response of IgG antibody and subclasses IgG1 and IgG2 against both, CagA and H. pylori membrane antigens in patients with precancerous lesions and cases with gastric cancer. We selected 137 patients with a positive serum IgG response to H. pylori: 46 with intestinal metaplasia, 41 with gastric adenocarcinoma and 50 with non-atrophic g...
Source: Journal of Medical Microbiology - January 3, 2013 Category: Microbiology Authors: de la Cruz-Herrera CF, Flores-Luna L, Gutierrez-Xicotencatl L, Chihu-Amparan L, Sanchez-Aleman MA, Lazcano-Ponce E, Torres J, Ayala G Tags: J Med Microbiol Source Type: research

Additional corpus biopsy enhances the detection of Helicobacter pylori infection in a background of gastritis with atrophy
This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree of gastritis with atrophy . Methods: One hundred and sixty-four (164) uninvestigated dyspepsia patients were enrolled. Biopsy-based tests (i.e., culture, histology Giemsa stain and rapid urease test) and non-invasive tests (anti-H. pylori IgG) were performed. The gold standard of H. pylori infection was defined according to previous criteria. The sensitivity, specificity, positive predictive rate and negative predictive rate of biopsy-based tests at the gastric antrum and body were calculated in terms of degree of gastritis with ...
Source: BMC Gastroenterology - December 29, 2012 Category: Gastroenterology Authors: Hung-Chieh LanTseng-Shing ChenAnna LiFull-Young ChangHan-Chieh Lin Source Type: research

Gastritis and colitis can be associated with XLP‐1 (SAP deficiency)
(Source: Pediatrics International)
Source: Pediatrics International - December 21, 2012 Category: Pediatrics Authors: Peter Christian Horn, Volker Schuster Tags: LETTERS TO THE EDITOR Source Type: research

Gastritis and colitis can be associated with XLP‐1 (SAP deficiency): Reply
(Source: Pediatrics International)
Source: Pediatrics International - December 21, 2012 Category: Pediatrics Authors: Xi Yang, Toshio Miyawaki, Hirokazu Kanegane Tags: LETTERS TO THE EDITOR Source Type: research

In vitro anti-inflammatory effect of apigenin in the Helicobacter pylori-infected gastric adenocarcinoma cells.
In this study, we investigated the anti-inflammatory effects of apigenin in H. pylori-infected MKN45 cells, for which IκBα, cyclooxygenase-2 (COX-2), intercellular adhesion molecule-1 (ICAM-1), reactive oxygen species (ROS), interleukin-8 (IL-8), IL-6, IL-1β, and mucin-2 (MUC-2) expressions were examined. Apigenin treatments (9.3-74 μM) significantly increased the IκBα expression, and thus inhibited nuclear factor kappa B (NF-κB) activation, and the inflammatory factor (COX-2, ICAM-1, ROS, IL-6, and IL-8) expressions decreased. The ROS levels decreased partially based on the intrinsic scavenging property of apigenin...
Source: Food and Chemical Toxicology - December 21, 2012 Category: Food Science Authors: Wang YC, Huang KM Tags: Food Chem Toxicol Source Type: research

Cathelicidin protects against Helicobacter pylori colonization and the associated gastritis in mice
, J J Y Sung, W K K Wu & C H Cho (Source: Gene Therapy)
Source: Gene Therapy - December 20, 2012 Category: Genetics & Stem Cells Authors: L ZhangJ YuC C M WongT K W LingZ J LiK M ChanS X RenJ ShenR L Y ChanC C LeeM S M LiA S L ChengK F ToR L GalloJ J Y SungW K K WuC H Cho Tags: cathelicidin H. pylori gastritis inflammation Source Type: research

Adherens junctions as targets of microorganisms: A focus on Helicobacter pylori
Abstract: Mucosal epithelia are targeted by several microorganisms as a way of adhesion, internalization, and/or exploitation of the host properties to induce disease. Helicobacter pylori are worldwide prevalent bacteria that colonize the human stomach. Persistent infection of the gastric mucosa with H. pylori and concurrent chronic gastritis are risk factors for ulcer disease and gastric carcinoma. Therefore, interactions at the H. pylori–epithelial interface are important to understand the pathogenesis of these bacteria and the host responses that contribute to disease development. Here, we provide an overview of the i...
Source: FEBS Letters - December 20, 2012 Category: Biochemistry Authors: Angela Margarida Costa, Marina Leite, Raquel Seruca, Ceu Figueiredo Tags: Review Source Type: research

Phase II study of autologous dendritic cell vaccination in patients with HER2 negative breast cancer combined with neoadjuvant chemotherapy
Conclusions The addition of autologous dendritic cell vaccines to neoadjuvant chemotherapy significantly increased the rate of pathological complete responses among patients with HER2-negative breast cancer. Vaccination does not seem to add any toxicity to the schedule.Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-16-03. (Source: Cancer Research)
Source: Cancer Research - December 17, 2012 Category: Cancer & Oncology Authors: Castillo, A., Salgado, E., Inoges, S., Arevalo, E., Castanon, E., Lopez, D. d. C. A., Sola, J., Pina, L., Nunez, J., Rodriguez-Spiteri, N., Espinos, J., Aramendia, J., Fernandez, H. O., Santisteban, M. Tags: Poster Session 5 - Treatment: Immunotherapy Source Type: research

H. pylori a risk factor for colonic neoplasms, large study confirms
NEW YORK (Reuters Health) - Gastritis related to Helicobacter pylori infection is associated with a relatively small increased risk of colonic neoplasm, according to data from a large US database. (Source: Modern Medicine)
Source: Modern Medicine - December 14, 2012 Category: Journals (General) Source Type: news

Relationship between Helicobacter pylori detection and an increased risk of infection in childhood
The risk of developing gastric cancer is believed to be related to differences among Helicobacter pylori strains and the inflammatory responses mediated by host genetic factors. H. pylori infection is acquired at an early age and in the absence of appropriate antibiotic therapy, it generally persists for life. Tp53 gene regulates the transcription of several cytokines and chemokines involved in innate immunity and its action may be influenced by the presence of different H. pylori strains. The present study aimed to detect H. pylori in pediatric patients, to access Tp53 polymorphism at codon 72 and to correlate such findin...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - December 12, 2012 Category: Tropical Medicine Source Type: research

H. pylori colonic neoplasm link confirmed
Helicobacter pylori gastritis is significantly associated with colonic neoplasms, show the results of one of the largest studies of the association to date. (Source: MedWire News - Gastroenterology)
Source: MedWire News - Gastroenterology - December 10, 2012 Category: Gastroenterology Source Type: news

Inhibition of lipopolysaccharide-induced nitric oxide and prostaglandin E2 production by chloroform fraction of Cudrania tricuspidata in RAW 264.7 macrophages
Conclusions: Our results show that the C. tricuspidata extract could modulate macrophage-mediated inflammatory functions such as the overproduction of cytokines, NO, and PGE2. The CTC was found to be the active fraction in this context. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - December 10, 2012 Category: Complementary Medicine Authors: Gabsik YangKyungjin LeeMihwa LeeInhye HamHo-Young Choi Source Type: research

Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa
Abstract Dendritic cells play an important role as antigen presenting cells that direct the nature of the adaptive immune response. Subtypes are differentiated by lineage, tissue, marker expression, and function. Their function in promoting regulatory T cells in the gut to maintain immunologic homeostasis is well documented but their role in the H. pylori infected stomach is less clear. Some analyses of bone marrow derived DCs stimulated with H. pylori have demonstrated proinflammatory potential based on secretion of IL‐12 or IL‐23 or activation of Th1 and Th17 cells. Other analyses indicate that H. pylori‐activated ...
Source: FEMS Immunology and Medical Microbiology - December 10, 2012 Category: Microbiology Authors: Jessica Shiu, Thomas G. Blanchard Tags: MiniReview Source Type: research

Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
Nature advance online publication 09 December 2012. doi:10.1038/nature11684 Authors: David Strugatsky, Reginald McNulty, Keith Munson, Chiung-Kuang Chen, S. Michael Soltis, George Sachs & Hartmut Luecke Half the world’s population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essential for survival in the acidic environment of the stomach. The channel is closed at neutral pH and opens at acidic pH to allow the rapid access of urea to cytoplasmic urease. Urease produ...
Source: Nature AOP - December 9, 2012 Category: Research Authors: David StrugatskyReginald McNultyKeith MunsonChiung-Kuang ChenS. Michael SoltisGeorge SachsHartmut Luecke Tags: Letter Source Type: research

Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori
; Hartmut Luecke Half the world’s population is chronically infected with Helicobacter pylori, causing gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma. Its proton-gated inner-membrane urea channel, HpUreI, is essential for survival in the acidic environment of the stomach. The channel is closed at neutral pH and opens at acidic pH to allow the rapid access of urea to cytoplasmic urease. Urease produces NH3 and CO2, neutralizing entering protons and thus buffering the periplasm to a pH of roughly 6.1 even in gastric juice at a pH below 2.0. Here we report the structure of HpUreI, re...
Source: Nature - December 9, 2012 Category: Research Authors: David StrugatskyReginald McNultyKeith MunsonChiung-Kuang ChenS. Michael SoltisGeorge SachsHartmut Luecke Tags: Letter Source Type: research

Trends in the eradication rates of Helicobacter pylori infection for eleven years.
CONCLUSION: This study showed that there was no trend change in the H. pylori eradication rate over the most recent 11 years in our institution. PMID: 23236238 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 7, 2012 Category: Gastroenterology Authors: Yoon JH, Baik GH, Sohn KM, Kim DY, Kim YS, Suk KT, Kim JB, Kim DJ, Kim JB, Shin WG, Kim HY, Baik IH, Jang HJ Tags: World J Gastroenterol Source Type: research