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This page shows you the latest news and research items in this category.

Management of distal aortic complications after repair of acute type A aortic dissection
Masseli et al report the use of antegrade stent grafting to treat acute complications early after surgery for acute type A aortic dissection. The previously surgically sewn ascending or arch Dacron graft was used as the entry point to antegrade deploy a stent graft in 5 patients with contained rupture or malperfusion. In 1 patient, the stent graft was inserted to treat exsanguination at the distal total arch suture line at the end of the primary operation. In the remaining 4 patients, the treatment occurred a few days after the primary procedure. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - June 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Eduard Quintana, Murat Ugur, Alberto Pochettino Tags: Letters to the Editor Source Type: research

Increased Muscle Mass In The Elderly Achieved By Dietary Supplement
A supplemental beverage used to treat muscle-wasting may help boost muscle mass among the elderly, according to a new study. The results were presented at The Endocrine Society's 95th Annual Meeting in San Francisco. The supplemental beverage, called Juven®, contains three amino acids, including arginine. Amino acids are the building blocks of proteins, and are required for cell growth and repair... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 18, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Previously Unknown Surveillance Mechanism Used By Cells To Monitor Oxidatively Damaged DNA
In current health lore, antioxidants are all the rage, as "everybody knows" that reducing the amount of "reactive oxygen species" -- cell-damaging molecules that are byproducts of cellular metabolism -- is critical to staying healthy. What everyone doesn't know is that our bodies already have a complex set of processes built into our cells that handle these harmful byproducts of living and repair the damage they cause... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 18, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

Comparison of repair techniques in small and medium-sized rotator cuff tears in cadaveric sheep shoulders.
CONCLUSION: No significant difference was found between the new knotless suture anchor techniques and traditional transosseous suture techniques. PMID: 23748617 [PubMed - in process] (Source: Acta Orthopaedica et Traumatologica Turcica)
Source: Acta Orthopaedica et Traumatologica Turcica - June 18, 2013 Category: Orthopaedics Authors: Onay U, Akpınar S, Akgün RC, Balçık C, Tuncay IC Tags: Acta Orthop Traumatol Turc Source Type: research

Laparoscopic VHR: Lower Cost of Care and Shorter Hospital Stay
(Ivanhoe Newswire) – A study led by Justin Lee, MD, of Tufts University School of Medicine, Boston, examined the outcomes of laparoscopic compared with open ventral hernia repair (VHR) in obese patients. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - June 18, 2013 Category: Consumer Health News Source Type: news

Incorporating time-delays in S-System model for reverse engineering genetic networks
Conclusion: The four well-known performance measures applied to the experimental studies on synthetic networks with various time-delayed regulations clearly demonstrate that the proposed method can capture both instantaneous and delayed interactions correctly with high precision. The experiments carried out on two well-known real-life networks, namely IRMA and SOS DNA repair network in Escherichia coli show a significant improvement compared with other state-of-the-art approaches for GRN modeling. (Source: BMC Bioinformatics - Latest articles)
Source: BMC Bioinformatics - Latest articles - June 18, 2013 Category: Bioinformatics Authors: Ahsan ChowdhuryMadhu ChettyNguyen Vinh Source Type: research

Nonpharmacologic Control of Postoperative Supraventricular Arrhythmias Using AV Nodal Fat Pad Stimulation in a Young Animal Open Heart Surgical Model [Original Articles]
Conclusions— Right inferior FP stimulation had a selective effect on the AV node, and slowed the ventricular rate during postoperative JET and atrial tachyarrhythmias in our young canine open heart surgery model. FP stimulation may be a useful new technique for managing children with JET and atrial tachyarrhythmias. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - June 18, 2013 Category: Cardiology Authors: Moak, J. P., Mercader, M. A., He, D., Trachiotis, G., Langert, J., Blicharz, A., Montaque, E., Li, X., Cheng, Y. I., McCarter, R., Bornzin, G. A., Martin, G. R., Jonas, R. A. Tags: Pacemaker, Animal models of human disease, Other Treatment, Pediatric and congenital heart disease, including cardiovascular surgery, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Primary repair of obstetric uterine rupture can be safely undertaken by non-specialist clinicians in rural Ethiopia: a case series of 386 women.
PMID: 23759091 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 17, 2013 Category: OBGYN Authors: Kelly J Tags: BJOG Source Type: research

Primary repair of obstetric uterine rupture can be safely undertaken by non-specialist clinicians in rural Ethiopia: a case series of 386 women.
PMID: 23759090 [PubMed - in process] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - June 17, 2013 Category: OBGYN Authors: Wright J Tags: BJOG Source Type: research

Repair of a Chondral Defect Using a Cell Free ScaffoldRepair of a Chondral Defect Using a Cell Free Scaffold
Should cell free scaffold be recommended as a general treatment procedure for articular cartilage defects? BMC Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 17, 2013 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Lung Function Dramatically Decreased By Chronic Drinking Plus Exposure To Particulate Matter
Alveolar macrophage (AM) function plays a critical role in protecting the lungs from particulate matter inhalation by removing particulates from the airway and secreting elements that facilitate airway repair. Chronic drinking causes persistent oxidative stress in the lungs, leading to impaired AM function as well as immune responses. A rodent study has found that chronic drinking, when coupled with particulate matter (PM) exposure, dramatically increases lung dysfunction compared to alcohol intake or PM exposure alone... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Minimally Invasive Pyeloplasty in Horseshoe Kidneys with Ureteropelvic Junction obstruction: A case series
Conclusions MIS repair of UPJ obstruction in horseshoe kidneys is feasible and safe. Although excellent short-term clinical success is achieved, radiographic success may be lower than MIS pyeloplasty in heterotopic kidneys, possibly due to inherent differences in anatomy. Larger studies are needed to evaluate MIS pyeloplasty in this population. (Source: International Braz J Urol)
Source: International Braz J Urol - June 16, 2013 Category: Urology & Nephrology Source Type: research

Selected Abstracts from the July Issue of the Journal of Vascular Surgery
This study assessed preliminary results of the Ventana Fenestrated System (Endologix, Irvine, Calif) as an off-the-shelf integrated device for juxtarenal aortic aneurysm (JAA) or pararenal aortic aneurysm (PAA) endovascular repair. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - June 16, 2013 Category: Surgery Tags: JVS Abstracts Source Type: research

Mismatch repair proteins in recurrent prostate cancer.
Abstract Normal cell function requires strict control over the repair of DNA damage, which prevents excessive mutagenesis. An enhanced accumulation of mutations results in the multistep process generally known as carcinogenesis. Defects in repair pathways fuel such mutagenesis by allowing reiterative cycles of mutation, selection, and clonal expansion that drive cancer progression. The repair of mismatches is an important mechanism in the prevention of such genetic instability. In addition, proteins of this pathway have the unique ability to function in DNA damage response by inducing apoptosis when irreparable dam...
Source: Clinical Prostate Cancer - June 16, 2013 Category: Cancer & Oncology Authors: Jarzen J, Diamanduros A, Scarpinato KD Tags: Adv Clin Chem Source Type: research

Prostate Cancer Screening in BRCA and Lynch Syndrome Mutation Carriers.
Abstract Prostate cancer (PrCa) remains a major public health burden worldwide. Screening programs have been established using the most efficient biomarker to date-prostate-specific antigen (PSA)-with the goal of earlier detection of this disease, which is thought to translate to a reduction in PrCa mortality. However, these screening programs have proved to be controversial following the publication of the two large, randomized, population-based studies in the United States and Europe. There is a recognized need for more refined screening strategies to address some of the deficiencies highlighted in these trials, ...
Source: Clinical Prostate Cancer - June 16, 2013 Category: Cancer & Oncology Authors: Castro E, Goh CL, Eeles RA Tags: Am Soc Clin Oncol Educ Book Source Type: research

The role of oxygen as a regulator of stem cell fate during fracture repair in TSP2‐null mice
This study therefore provides further support for the hypothesis that oxygen availability during early fracture healing is a key regulator of MSC bipotential differentiation, and furthermore, it highlights the advantages of integrating computational models with genetically modified mouse studies for further elucidating mechanisms regulating stem cell fate. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 9999:1–12, 2013. (Source: Journal of Orthopaedic Research)
Source: Journal of Orthopaedic Research - June 16, 2013 Category: Orthopaedics Authors: Darren Burke, Michael Dishowitz, Mariya Sweetwyne, Emily Miedel, Kurt D. Hankenson, Daniel J. Kelly Tags: Research Article Source Type: research

[In Context] Giselle Petzinger
Giselle Petzinger is a movement disorder specialist at the University of Southern California in Los Angeles, CA, USA, with a primary interest in translational neuroscience. She investigates the role of exercise and experience on brain repair in animal models of Parkinson's disease and translates these findings to clinical research studies and clinical care for individuals with Parkinson's disease. (Source: Lancet Neurology)
Source: Lancet Neurology - June 16, 2013 Category: Neurology Authors: The Lancet Neurology Tags: In Context Source Type: research

Concurrent repair of orbital shallowness with craniosynostosis surgery: two late cases of simultaneous orbital decompression.
Abstract Early closure of cranial sutures results in various types of cranial vault deformities, named craniosynostosis. Although mostly associated with syndromic cases, bony orbit deformities such as exorbitism can be seen with various types of craniosynostosis. This condition can be associated with papilledema and besides its effect on the patient's appearance can cause subluxation of the globe, lagophthalmos or keratitis resulting in corneal ulcers and ultimately loss of vision. Various techniques have been proposed for repair or exorbitism such as fronto-orbital advancement procedures, orbital wall decompressio...
Source: Turkish Neurosurgery - June 16, 2013 Category: Neurosurgery Authors: Oreroglu AR, Silav G, Ozkaya O, Orman C, Akan M Tags: Turk Neurosurg Source Type: research

Feasibility study on repair for cranial defect of immaturity.
CONCLUSION: Closure of cranial defects with a titanium mesh did not limit growth of the cranium or cause abnormal central nervous system development. While there was new bone growth in the cranial defects, the bone was not sufficiently strong to withstand external trauma. PMID: 23756975 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - June 16, 2013 Category: Neurosurgery Authors: Zhang C, Wang Z, Shi R, Feng S, Sun J, Wang W, Su L, Zhang A Tags: Turk Neurosurg Source Type: research

The future of buildings: coming soon, the house that can repair itself
How self-healing concrete and 3D printing will transform buildings and many other sectors besidesBuildings will be very different because currently they are not very hi-tech. They are still made from concrete, steel and glass. The wiring and plumbing of a building will soon start to become integrated and grown like our bodies' nervous and digestive systems. More materials will be able to heal themselves and they'll clean themselves.Some of these technologies are already being developed – such as self-healing concrete – and at the moment cost is holding back their introduction, but that will change. Obviously there are ...
Source: Guardian Unlimited Science - June 15, 2013 Category: Science Authors: Mark Miodownik Tags: Construction industry Art and design Technology 3D printing Editorial The Observer Architecture Business Science Source Type: news

The future of robotics: in a transhuman world, the disabled will be the ones without prosthetic limbs
Bertolt Meyer's amazing bionic hand controlled by an iPhone app is a glimpse of the advances being made in prosthetics. But in years to come, will everyone want one?Bertolt Meyer is used to being viewed as not fully human. Born with a stump where his left hand should have been, he spent his childhood wearing a hook connected to an elaborate pulley and harness. "To open the hook and grasp things I had to flex my shoulders like this," he says, striking a he-man pose. "The harness was very uncomfortable. To stop it chafing my skin, I had to wear a shirt underneath it at all times. I was always sweating."Even when, at the age ...
Source: Guardian Unlimited Science - June 15, 2013 Category: Science Authors: Mark Honigsbaum Tags: Robots Sport Disability sport Society FutureFest Drugs in sport Technology Editorial The Observer Science Source Type: news

Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high‐risk patients undergoing hybrid stage I palliation: Recommendations to optimize ductal stent positioning
ConclusionsMid‐ to long‐term follow‐up indicates that PDA stents remain widely patent regardless of ductal morphology until comprehensive stage II repair. © 2013 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - June 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Michael R. Recto, Sandy Doyle, Vitor C. Guerra, Song Gui Yang, Thomas Yeh Tags: Pediatric and Congenital Heart Disease Source Type: research

New findings regarding DNA damage checkpoint mechanism in oxidative stress
(University of North Carolina at Charlotte) Researchers have uncovered a previously unknown surveillance mechanism, known as a DNA damage checkpoint, used by cells to monitor oxidatively damaged DNA. DNA repair takes place approximately 10,000 times per cell, per day, through processes that are still only partially understood because of their complexity, speed, and the difficulty of studying complex interactions within living cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 14, 2013 Category: Global & Universal Source Type: news

Stroke neuroprotection: Estrogen and IGF‐1 interactions and the role of microglia
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - June 14, 2013 Category: Endocrinology Authors: Farida Sohrabji, Madison Williams Tags: Review Article Source Type: research

Dose‐dependent effect of mitomycin C on human vocal fold fibroblasts
ConclusionA total of 0.2 mg/mL mitomycin C may provide initial and transient stimulation of collagen for necessary repair to damaged tissue without the long‐term risk of fibrosis. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Nicole Y. K. Li, Fei Chen, Frederik G. Dikkers, Susan L. Thibeault Tags: Original Article Source Type: research

Autocrine and immune cell derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration
In conclusion, BDNF is an autocrine factor for skeletal muscle cells and may regulate human myogenesis. Furthermore, the preferential localisation of BDNF producing immune cells near p75NTR positive regenerating myofibers suggests that immune cell derived BDNF may sustain tissue repair in inflamed muscle. (Source: The Journal of Pathology)
Source: The Journal of Pathology - June 14, 2013 Category: Pathology Authors: Emanuela Colombo, Francesco Bedogni, Isabella Lorenzetti, Nicoletta Landsberger, Stefano C. Previtali, Cinthia Farina Tags: Original Article Source Type: research

Clinical and radiological results of arthroscopic repair of massive rotator cuff tears does it improve the natural history.
CONCLUSION: The results suggest that arthroscopic repair of massive rotator cuff tears can achieve excellent clinical results The outcome in the longer term is unknown. PMID: 23757636 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Chrysi T, Chidanbaram R, Frankiskos X, Mok DH Tags: Br J Sports Med Source Type: research

Importance of genetic variants and ethnicity in non-contact musculoskeletal soft tissue injuries.
CONCLUSIONS: SNPs study constitutes a new field of investigation in Sports Medicine which will help us to identify individuals with shorter recovery and those with greater risk of injury. Our results are only the pave to demonstrate that these genotyping interracial differences are important when studying injuries and let us to indicate that the genetic profile based on the SNPs can be use to describe, as objectively as possible each individuals injurability risk and may well be a useful tool for football players to receive a more specific treatment and preventive care options. PMID: 23757662 [PubMed - in process] (Sou...
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Ricard P, Rosa A, Jordi R, Bruno M, Mariano M Tags: Br J Sports Med Source Type: research

Arthroscopic findings and functional outcome of shoulder injury in the young overhead athletes.
CONCLUSION: Functional characteristics of shoulder complex measured with Constant score of overhead and non-overhead athletes statistically significant increased 2 years after the arthroscopic surgery. Significant change of external rotation was established in overhead athletes: 2 years after surgery it was significantly smaller. Sports specific and diagnose-based rehabilitation is needed to decrease deficit in function of the shoulder complex after concomitant arthroscopic type II SLAP and PTRC repair. PMID: 23757658 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Gudas R, Siupsinskas L, Mauriciene V Tags: Br J Sports Med Source Type: research

Treatment of ankle impingement syndromes in athletes.
CONCLUSION: Arthroscopic treatment of anterior ankle impingement together with ankle ligament reconstruction, when indicated, is essential for obtaining a stable and functionally efficient ankle. PMID: 23757697 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Intzirtis P, Tsikouris G, Zampiakis E, Plessas S, Taprantzis L, Kourougenis P, Tsikouris D, Tsikouris L Tags: Br J Sports Med Source Type: research

Reporting on acl deficient patients: a function-based return-to-activity algorithm.
CONCLUSION: In this case report, an athlete returned to his previous sport level within a period of twenty weeks. The proposed return-to-activity algorithm was easy applicable and helpful to control the different rehabilitation phases. On the basis of such a procedure, individual recommendations are decoupled from time-oriented approaches. Thus musculo-skeletal function becomes a central component in judging progressions during rehabilitation. PMID: 23757694 [PubMed - in process] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - June 13, 2013 Category: Sports Medicine Authors: Keller M, Schmidtlein O, Kurz E Tags: Br J Sports Med Source Type: research

Type 2 alveolar cells are stem cells in adult lung
Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo clonal lineage analysis, different injury/repair systems, and in vitro culture of purified cell populations to obtain new information about the contribution of AEC2s to alveolar maintenance and repair. Genetic lineage-tracing experiments showed that surfactant protein C–positive (SFTPC-positive) AEC2s self renew and differentiate over about a year, consistent with the population containing long-term alve...
Source: Journal of Clinical Investigation - June 13, 2013 Category: Biomedical Science Authors: Christina E. Barkauskas, Michael J. Cronce, Craig R. Rackley, Emily J. Bowie, Douglas R. Keene, Barry R. Stripp, Scott H. Randell, Paul W. Noble, Brigid L.M. Hogan Source Type: research

Mitral valve pathology in severely impaired left ventricles can be successfully managed using a right-sided minimally invasive surgical approach [ADULT CARDIAC]
CONCLUSIONS Mini-MV surgery in patients with significantly impaired left ventricular function can be performed with a reasonable operative mortality and acceptable long-term survival for this high-risk patient cohort. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Garbade, J., Seeburger, J., Merk, D. R., Pfannmuller, B., Vollroth, M., Barten, M. J., Borger, M. A., Mohr, F.-W. Tags: ADULT CARDIAC Source Type: research

Transcatheter valve-in-ring implantation after failure of surgical mitral repair [ADULT CARDIAC]
CONCLUSIONS These preliminary results suggest that TVIR is feasible, with low operative risk, and may provide short-term clinical and haemodynamic improvement in selected high-risk patients with failure of mitral ring annuloplasty. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Descoutures, F., Himbert, D., Maisano, F., Casselman, F., de Weger, A., Bodea, O., Van der Kley, F., Colombo, A., Giannini, C., Rein, K. A., De Bruyne, B., Petronio, A. S., Dahle, G., Alfieri, O., Vahanian, A. Tags: ADULT CARDIAC Source Type: research

Mitral valve repair and bioprosthetic replacement without postoperative anticoagulation does not increase the risk of stroke or mortality [ADULT CARDIAC]
CONCLUSIONS Despite current guidelines recommending postoperative anticoagulation following MVRR or bioprosthetic replacement, the avoidance of warfarin does not increase perioperative complications and has no impact on intermediate survival. Accordingly, a prospective randomized study to adjudicate the role of extended warfarin thromboprophylaxis in mitral valve surgery is warranted. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Schwann, T. A., Engoren, M., Bonnell, M., Clancy, C., Khouri, S., Kabour, A., Jamil, T., Habib, R. H. Tags: ADULT CARDIAC Source Type: research

Management of moderate secondary mitral regurgitation at the time of aortic valve surgery [ADULT CARDIAC]
CONCLUSIONS Secondary MR improves after AVR even without mitral surgery. Concomitant mitral surgery was significantly associated with greater improvement of postoperative MR, but had no significant impact on survival. However, patients who did not improve immediately after AVR had compromised survival. Patients in AF should have mitral valve repair at the time of surgery. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Coutinho, G. F., Correia, P. M., Pancas, R., Antunes, M. J. Tags: ADULT CARDIAC Source Type: research

A 17-year experience with mitral valve repair with artificial chordae in infants and children [CONGENITAL]
CONCLUSIONS MV repair with artificial chordae in infants and children is safe and effective and associated with a low reoperation rate. Further investigation into the long-term durability and biological adaptation of ePTFE sutures after patient growth is mandatory. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Oda, S., Nakano, T., Tatewaki, H., Hinokiyama, K., Machida, D., Kado, H. Tags: CONGENITAL Source Type: research

Cardiac surgery in patients with a porcelain aorta in the era of transcatheter valve implantation [ADULT CARDIAC]
CONCLUSIONS Conventional cardiac and aortic surgery offers definitive repair and can be performed safely using current perfusion and operative techniques. Although more invasive, this surgical technique provides mortality and morbidity rates that do not exceed those reported for transcatheter valve implantation. The curative replacement of the pathological proximal aorta, which is one of the most main sources of cerebral embolism, leads to excellent neurological outcome during mid- to long-term follow-up. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Urbanski, P. P., Raad, M., Wagner, M., Heinz, N., Reents, W., Diegeler, A. Tags: ADULT CARDIAC Source Type: research

A new classification system for branch artery perfusion patterns in acute aortic dissection for examining the effects of central aortic repair [AORTIC SURGERY]
CONCLUSIONS To overcome malperfusion syndromes associated with acute aortic dissection, recognition of diverse branch perfusion patterns through a universal classification system is imperative. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Nagamine, H., Ueno, Y., Ueda, H., Saito, D., Tanaka, N., Miyazaki, M., Hara, H., Kawase, Y. Tags: AORTIC SURGERY Source Type: research

Results of high-risk endovascular procedures in patients with non-dissected thoracic aortic pathology: intermediate outcomes [AORTIC SURGERY]
CONCLUSIONS Mid-term outcome after TEVAR does not differ between patients with favourable and unfavourable landing zone anatomy in terms of aorta-related survival. However, the more frequent need for secondary intervention warrants a more rigorous follow-up after TEVAR in patients with unfavourable anatomy. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Rylski, B., Blanke, P., Siepe, M., Kari, F. A., Euringer, W., Sudkamp, M., Beyersdorf, F. Tags: AORTIC SURGERY Source Type: research

Late complications and distal growth rates of Marfan aortas after proximal aortic repair [AORTIC SURGERY]
CONCLUSIONS Late distal complication rates are low for patients initially presenting with aneurysms. The risk of late distal reoperation is dictated by the initial pathology and by the presence of an initial dissection and not by faster distal aortic growth. Strategies to completely restore a non-dissected anatomy might improve late surgical outcome in Marfan's syndrome. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kari, F. A., Russe, M. F., Peter, P., Blanke, P., Rylski, B., Euringer, W., Beyersdorf, F., Siepe, M. Tags: AORTIC SURGERY Source Type: research

Rescue operation after ascending thoracic endovascular aortic repair in a patient with thrombosis of the left main coronary ostium [CASE REPORT]
We report on a 68-year old male patient who presented to our clinic with angina-pectoris-like chest pain after having been treated with an aortic stent graft. A computed tomography scan revealed a thrombus in the left main stem that could be successfully removed. The aortic stent graft was removed and the supracoronary ascending aorta replaced. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Blehm, A., Smiris, K., Schurr, P., Lichtenberg, A. Tags: CASE REPORT Source Type: research

Endovascular aortic repair for a pulmonary aspergilloma fistulized into the descending aorta: selective intubation with a single-lumen tube under fluoroscopic guidance [IMAGES IN CARDIO-THORACIC SURGERY]
(Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Cil, B., Peynircioglu, B., Dogu Geyik, F., Citak, N. Tags: IMAGES IN CARDIO-THORACIC SURGERY Source Type: research

Does only the proximal descending aorta influence aortic dilatation after repair of the aortic dissection? [LETTERS TO THE EDITOR]
(Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ugur, M., Pochettino, A., Anantha Narayanan, M., Schaff, H. V. Tags: LETTERS TO THE EDITOR Source Type: research

Emergency cardiac surgery during transfemoral and transapical transcatheter aortic valve implantation: incidence, reasons, management and outcome of 411 patients from a single centre
Conclusions ‐ Life‐threatening complications requiring bail‐out ECS occur in a substantial proportion during TAVI. ECS dramatically affects early and late outcome after TAVI. Under optimal conditions more than half of the ECS‐patients can be salvaged. With the current technology of THV‐systems ECS should be an integral part of the logistic conditions surrounding TAVI and is far from being futile in this patient population. © 2013 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - June 13, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Daniel P. Griese, Wilko Reents, Sebastian Kerber, Anno Diegeler, Jörg Babin‐Ebell Tags: Original Study Source Type: research

Chronic Alcohol Induces M2 Polarization Enhancing Pulmonary Disease Caused by Exposure to Particulate Air Pollution
ConclusionsCombustion‐derived PM inhalation causes enhanced disease severity in the alcoholic lung by stimulating the release of latent TGF‐β stores in AMs. The combinatorial effect of elevated TGF‐β, M2 polarization of AMs, and increased oxidative stress impairs pulmonary function by increasing airway collagen content and compromising alveolar integrity. (Source: Alcoholism: Clinical and Experimental Research)
Source: Alcoholism: Clinical and Experimental Research - June 13, 2013 Category: Addiction Authors: Paul Thevenot, Jordy Saravia, Joseph Giaimo, Kyle I. Happel, Tammy R. Dugas, Stephania A. Cormier Tags: Original Article Source Type: research

APOBEC3 in Cancer Promotion
High frequency of cytidine to thymidine conversions was identified in the genome of several types of cancer cells. In breast cancer cells, these mutations are clustered in long DNA regions associated with single-strand DNA (ssDNA), double-strand DNA breaks (DSB), and genomic rearrangements. The observed mutational pattern resembles the deamination signature of cytidine to uridine carried out by members of the APOBEC3 family of cellular deaminases. Consistently, APOBEC3B (A3B) was recently identified as the mutational source in breast cancer cells. A3G is another member of the cytidine deaminases family predominantly expres...
Source: Cancer Research - June 13, 2013 Category: Cancer & Oncology Authors: Nowarski, R., Kotler, M. Tags: Perspective Source Type: research

Effects of ATR versus Chk1 Inhibition in Ovarian Cancer Cells
In this study, we examined the respective roles of the ATR and Chk1 kinases in ovarian cancer cells using genetic and pharmacologic inhibitors in combination with cisplatin, topotecan, gemcitabine, and the PARP inhibitor veliparib (ABT-888), four agents with clinical activity in ovarian cancer. RNA interference (RNAi)–mediated depletion or inhibition of ATR sensitized ovarian cancer cells to all four agents. In contrast, while cisplatin, topotecan, and gemcitabine each activated Chk1, RNAi-mediated depletion or inhibition of this kinase in cells sensitized them only to gemcitabine. Unexpectedly, we found that neither the...
Source: Cancer Research - June 13, 2013 Category: Cancer & Oncology Authors: Huntoon, C. J., Flatten, K. S., Wahner Hendrickson, A. E., Huehls, A. M., Sutor, S. L., Kaufmann, S. H., Karnitz, L. M. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

The opportunistic pathogen Pseudomonas aeruginosa activates the DNA double-strand break signaling and repair pathway in infected cells.
Abstract Highly hazardous DNA double-strand breaks can be induced in eukaryotic cells by a number of agents including pathogenic bacterial strains. We have investigated the genotoxic potential of Pseudomonas aeruginosa, an opportunistic pathogen causing devastating nosocomial infections in cystic fibrosis or immunocompromised patients. Our data revealed that infection of immune or epithelial cells by P. aeruginosa triggered DNA strand breaks and phosphorylation of histone H2AX (γH2AX), a marker of DNA double-strand breaks. Moreover, it induced formation of discrete nuclear repair foci similar to gamma-irradiation-...
Source: Cellular and Molecular Life Sciences : CMLS - June 13, 2013 Category: Cytology Authors: Elsen S, Collin-Faure V, Gidrol X, Lemercier C Tags: Cell Mol Life Sci Source Type: research

Breakage-fusion-bridge Cycles and Large Insertions Contribute to the Rapid Evolution of Accessory Chromosomes in a Fungal Pathogen
by Daniel Croll, Marcello Zala, Bruce A. McDonald Chromosomal rearrangements are a major driver of eukaryotic genome evolution, affecting speciation, pathogenicity and cancer progression. Changes in chromosome structure are often initiated by mis-repair of double-strand breaks in the DNA. Mis-repair is particularly likely when telomeres are lost or when dispersed repeats misalign during crossing-over. Fungi carry highly polymorphic chromosomal complements showing substantial variation in chromosome length and number. The mechanisms driving chromosome polymorphism in fungi are poorly understood. We aimed to identify mechan...
Source: PLoS Genetics - June 13, 2013 Category: Genetics & Stem Cells Authors: Daniel Croll et al. Source Type: research