Finding a cure for Fido's brain cancer may help us find a cure for ourselves
(Jackson Laboratory) For cancers such as glioma, preclinical research models have failed to provide sufficient insight for medical progress. A team led by Jackson Laboratory's Roel Verhaak thoroughly analyzed sporadic canine gliomas and found that their molecular characteristics, including gene mutations and duplications, resemble those of humans. The results indicate that dogs provide an effective model for human gliomas, and learning how to more effectively treat our pets will likely inform better prognoses for human patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Poliovirus therapy shows potential as cancer vaccine in lab studies
A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as part of a cancer vaccine. In preclinical studies using mice and human cancer cells, an injection of the modified poliovirus vector instigated an immune response that homed in on mutated cancer cells that predominate in diffuse midline glioma (DMG) tumors. The cancer strikes children and is universally deadly. (Source: World Pharma News)
Source: World Pharma News - January 30, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Brain tumors remodel neuronal synapses to promote growth
(Baylor College of Medicine) Scientists discovered that glioma, a lethal form of brain cancer, alters the activity of neighboring neurons, accelerating a vicious cycle that drives tumor-associated epilepsy and tumor progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 29, 2020 Category: Cancer & Oncology Source Type: news

Study uncovers unexpected connection between gliomas, neurodegenerative diseases
(Michigan Medicine - University of Michigan) New basic science and clinical research identifies TAU, the same protein studied in the development of Alzheimer's, as a biomarker for glioma development. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2020 Category: Cancer & Oncology Source Type: news

Surgery May Add Years for Patients With Deadly Brain Cancer: Study
WEDNESDAY, Jan. 20, 2020 -- Surgical removal of the entire tumor may extend the lives of patients with a rare and deadly type of brain cancer called brainstem high-grade gliomas, a new study suggests. Researchers analyzed data from 103 patients in... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 15, 2020 Category: General Medicine Source Type: news

Peering into the genome of brain tumor
(Osaka University) Scientists at Osaka University have created a machine learning method for classifying the mutations of glioma brain tumors based on MR images alone. Thus far, classification has only been possible by tissue sampling during surgery. The new method is noninvasive, may remove the need for a tissue sample and help accelerate delivery of treatment for patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 9, 2020 Category: Cancer & Oncology Source Type: news

Connecticut boy, seven, with fatal brain tumor spends last Christmas home
Trenton O'Brien, seven, of East Haven, Connecticut, was diagnosed with a brain tumor called Diffuse Intrinsic Pontine Glioma in June 2019. He's been home, in hospice care, since Christmas Eve. (Source: the Mail online | Health)
Source: the Mail online | Health - January 6, 2020 Category: Consumer Health News Source Type: news

New Mom With Brain Tumor Turns To Boston Hospital For Keyhole Brain Surgery
BOSTON (CBS) — Imagine giving birth to a premature baby and then being told you have a brain tumor. That’s what happened to a woman from Holden. But thanks to a new approach at Brigham and Women’s Hospital, this new mom was able to have brain surgery and quickly return to her newborn son. At 27 weeks pregnant, Bethany Shea was diagnosed with preeclampsia and had an emergency C-section. Then she went blind. “It was a pregnancy complication due to my high blood pressure,” Bethany explained. Bethany regained her vision, but worried she had had a stroke, doctors ordered an MRI. But instead of a stroke, it reveale...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 30, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Brigham and Women's Hospital Dr. Mallika Marshall Source Type: news

Perioperative Study of Vorasidenib Shows Promise for Patients with Low-Grade Glioma
A perioperative study confirmed brain penetrance and robust biomarker suppression in patients with low-grade glioma with an IDH1 mutation. (Source: CancerNetwork)
Source: CancerNetwork - November 27, 2019 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

NF decline but stable QOL in 1st year after temozolomide-based chemoradiotherapy
(NRG Oncology) A secondary analysis of the NRG Oncology clinical trial NRG-RTOG 0424, which initially reported a 73.1% 3-year overall survival rate, shows a decline in neurocognitive function (NCF) for half of the trial participants with high risk, low-grade gliomas (HR-LGGs) up to a year after receiving concurrent chemoradiotherapy with temozolomide. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 25, 2019 Category: Cancer & Oncology Source Type: news

Scientists drug combo that may give some hope for lethal childhood brain cancer sufferers
After using computer algorithms to sour through 9,000 possible drug combinations, Stanfors scientists found a pair with potential for treating diffuse intrinsic glioma, a rare and lethal childhood cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - November 22, 2019 Category: Consumer Health News Source Type: news

Scientists find promising drug combination against lethal childhood brain cancers
(NIH/National Center for Advancing Translational Sciences (NCATS)) Researchers have devised a new, promising plan of attack against deadly childhood brain cancers called diffuse midline gliomas (DMG). NCATS and Stanford University scientists and their colleagues showed that combining two drugs killed DMG patient cells grown in the laboratory and in animal models. The drugs countered the effects of a genetic mutation that causes the diseases. Their studies also uncovered an unrecognized vulnerability in the cancer cells that scientists may be able to exploit. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 20, 2019 Category: International Medicine & Public Health Source Type: news

How do gliomas evolve?
(Jackson Laboratory) The Glioma Longitudinal Analysis (GLASS) Consortium characterized diffuse glioma cells both before and after therapy to characterize how they change and why this form of malignant brain cancer is so difficult to treat. The findings provide a foundation for further research and the opportunity for the clinical community to predict the effectiveness of newly developed treatments. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 20, 2019 Category: Biology Source Type: news

Pioneering blood test which uses AI to quickly scan for brain tumours is up to 90% accurate
The test, developed by University of Edinburgh, was able to identify signs gliomas, the most common form of brain tumour, with a 90 per cent success rate. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2019 Category: Consumer Health News Source Type: news

Science Saturday: Glioma Forecast? Excellent Chance for Better Weather says Researcher
Entering the Mathematical Neuro-Oncology lab on Mayo Clinic's location in Scottsdale, Arizona, is like walking onto the bridge of a ship in some fictional universe. There's a definite "Star Trek" vibe. "Yes, 'Star Trek' is good," laughs Kristin Swanson, Ph.D., a mathematical oncologist at Mayo Clinic, "but I like 'Big Bang Theory.' I kind of joke that that's [...] (Source: Mayo Clinic Research News)
Source: Mayo Clinic Research News - October 25, 2019 Category: Research Source Type: news