FET-PET offers more info on treatment of brain metastases
Using PET with the radiolabeled amino acid F-18 fluoroethyl-tyrosine (F-18-FET)...Read more on AuntMinnie.comRelated Reading: FET-PET can be useful for glioma evaluations FET-PET adds 'relevant' info to pediatric cancer cases SNMMI: FET-PET could have answers for brainstem glioma SNMMI: FET-PET aids pediatric brain cancer patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 14, 2020 Category: Radiology Source Type: news

The road to recovery: a pilot study of driving behaviors following antibody-mediated encephalitis - Day GS, Babulal GM, Rajasekar G, Stout S, Roe CM.
INTRODUCTION: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma-inacti... (Source: SafetyLit)
Source: SafetyLit - August 31, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Genomic analysis predicts survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in low-grade gliomas in NRG Oncology clinical trial
(NRG Oncology) A practice-changing study, NRG Oncology clinical trial NRG-RTOG 9802, has demonstrated, for the first time, a survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in certain subgroups of patients with high-risk, low-grade glioma (WHO classification: LGG, grade II), a type of brain tumor that originates from glial cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 31, 2020 Category: Cancer & Oncology Source Type: news

FEFU scientists are developing genetic methods to understand malignant tumors
(Far Eastern Federal University) Scientists of Far Eastern Federal University (FEFU University) get started studying the formation and survival mechanisms of the brain malignant tumors cells, i.e. glioma, to reveal new ways for diagnosis and therapy for this fatal disease. This research was supported by the grant from Russian Science Foundation (RSF). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 31, 2020 Category: Cancer & Oncology Source Type: news

Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body's natural production of alpha-ketoglutarate extended the lives of mice harboring DIPG tumors by slowing the growth of the cancer cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 18, 2020 Category: Cancer & Oncology Source Type: news

The structural basis of Focal Adhesion Kinase activation on lipid membranes unravelled
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) * Patients with glioma - a very common type of tumour originating in the brain - see improvement in survival rates with combined treatment of radiotherapy plus temozolomide* Researchers found a novel mechanism on how tumours evade chemotherapy through genomic rearrangements of the MGMT DNA repair gene* This finding is potentially relevant for updating the methods used to monitor temozolomide efficacy. Genomic rearrangement could be a marker to be detected in blood samples and help make therapeutic decisions (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 11, 2020 Category: Cancer & Oncology Source Type: news

A research team of the CNIO and the HKUST identifies how some gliomas develop chemoresistance
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) * Patients with glioma - a very common type of tumour originating in the brain - see improvement in survival rates with combined treatment of radiotherapy plus temozolomide* Researchers found a novel mechanism on how tumours evade chemotherapy through genomic rearrangements of the MGMT DNA repair gene* This finding is potentially relevant for updating the methods used to monitor temozolomide efficacy. Genomic rearrangement could be a marker to be detected in blood samples and help make therapeutic decisions (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 4, 2020 Category: Cancer & Oncology Source Type: news

New treatment strategy may benefit patients with brain cancer
(Massachusetts General Hospital) A team led by investigators at Massachusetts General Hospital has uncovered a potentially promising strategy to treat gliomas with mutations in the IDH genes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 30, 2020 Category: Cancer & Oncology Source Type: news

CNS Announces the FDA has Granted Orphan Drug Designation for Brain Cancer Drug Berubicin
HOUSTON, June 11, 2020 -- (Healthcare Sales & Marketing Network) -- CNS Pharmaceuticals, Inc., (Nasdaq: CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and me... Biopharmaceuticals, Oncology, Neurology, FDA CNS Pharmaceuticals, Berubicin, glioma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 11, 2020 Category: Pharmaceuticals Source Type: news

Ludwig Lausanne study charts the immune landscape of multiple brain cancers
(Ludwig Institute for Cancer Research) A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 28, 2020 Category: Cancer & Oncology Source Type: news

Brain tumors respond well to combo of radiation, schizophrenia drug
Researchers at theUCLA Jonsson Comprehensive Cancer Center and colleagues have found that adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma, one of the deadliest and most difficult-to-treat brain tumors.The findings,published May 1 in Proceedings of the National Academy of Sciences, show that a combination of radiation and the drug trifluoperazine not only targets glioblastoma cells but also helps overcome the resistance to treatment so common to this aggressive form of cancer. The results could prove promising for patients wit...
Source: UCLA Newsroom: Health Sciences - May 2, 2020 Category: Universities & Medical Training Source Type: news

Could AI Help Doctors Map Out Treatments for Brain Cancers?
FRIDAY, April 24, 2020 -- Artificial intelligence may reduce the need for glioma brain cancer patients to have biopsies to determine the best treatment for their tumors, researchers report. Currently, it ' s common to remove glioma samples from... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 24, 2020 Category: General Medicine Source Type: news

Study reveals how 'hypermutated' malignant brain tumors escape chemotherapy and immunotherapy
(Dana-Farber Cancer Institute) An analysis of more than 10,000 gliomas and clinical outcomes reported in Nature by scientists in Boston and Paris found that glioma patients whose tumors were hypermutated actually had no significant benefit when treated with checkpoint blockers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2020 Category: International Medicine & Public Health Source Type: news

Mouse study shows how advancing glioma cells scramble brain function, blood flow
(The Zuckerman Institute at Columbia University) The first sign of trouble for a patient with a growing brain tumor is often a seizure. Such seizures have long been considered a side effect of the tumor. But now a joint team of Columbia engineers and cancer researchers studying brain tumors has found evidence that the seizures caused by an enlarging tumor could spur its deadly progression. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 14, 2020 Category: Biology Source Type: news

New findings shed light on selective therapeutics for IDH1-mutated glioma
(Chinese Academy of Sciences Headquarters) Findings of a new study led by Prof. XU Guowang from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences and Prof. YANG Chunzhang from the National Cancer Institute shed light on the selective therapeutics for IDH1-mutated glioma by targeting glutathione synthesis pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2020 Category: Cancer & Oncology Source Type: news