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Improved Outcomes Following Drug-Resistant Immunotherapy in a Hunan Xenograft Model of Temozolomide-Resistant Glioblastoma Multiforme
Conventional treatment strategies for Temozolomide (TMZ)-resistant high-grade gliomas have been uniformly dismal. Our previous studies have shown that TMZ-resistant tumors upregulate stress-associated NKG2D ligands (NKG2DL) during the first several hours following exposure to TMZ, thereby creating an opportunity for NKG2DL-directed cell therapy, particularly ex vivo expanded/activated γδ T cells and NK cells that directly recognize these stress-associated antigens. Using a human/mouse primary xenograft model, we report improved survival using a combination of TMZ chemotherapy and gene modified TMZ-resistant γδ T cell...
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Harold Trent Spencer, Anindya Dasgupta, George Yancey Gillespie, Larisa Pereboeva, Kathryn S. Sutton, Lawrence Lamb Tags: Solid Tumors Source Type: research

The role of diffusion tensor tractography in the surgical treatment of pediatric optic chiasmatic gliomas
Abstract Diffusion tensor tractography(DTT) can theoretically be used in assessing the optic chiasmatic glioma(OCGs),which are still in debate about optimal treatment. The purpose of this study was to investigate the role of this technology in offering more information about the tumor, assisting the debulking surgery, and helping to anticipate visual outcomes. As a prospective cohort study, the enrolled patients received routine pre- and postoperative neuro-ophthalmology, neuroimaging, and endocrine examinations. Fiber tractography was meanwhile performed based on diffusion tensor imaging examination. Identificati...
Source: Journal of Neuro-Oncology - January 24, 2015 Category: Cancer & Oncology Source Type: research

Hypewatch: Glioma-Birth Control Link Oversold? (CME/CE)
(MedPage Today) -- Media seized on a link between glioma and hormonal contraceptives, but extra risk is tiny. (Source: MedPage Today Endocrinology)
Source: MedPage Today Endocrinology - January 23, 2015 Category: Endocrinology Source Type: news

Plasma miR-454-3p as a potential prognostic indicator in human glioma
Abstract microRNAs (miRNAs) are a class of small non-coding RNAs, approximately 21–25 nucleotides in length. Recently, some researchers have demonstrated that plasma miRNAs are sensitive and specific biomarkers of various cancers. Using quantitative real-time PCR, the expression levels of miR-454-3p were compared between pre-operative plasmas from 70 glioma patients and 70 healthy controls, and between these pre-operative and post-operative plasmas. Kaplan–Meier analysis was used to evaluate the association of miR-454-3p with prognosis of glioma patients. The expression levels of miR-454-3p in plasma in gliom...
Source: Neurological Sciences - January 23, 2015 Category: Neurology Source Type: research

Diffuse, non-traumatic, non-aneurysmal subarachnoid haemorrhage during bevacizumab treatment of high grade glioma: case report and review of the literature
Conclusion We discuss here a case of diffuse, non-traumatic SAH during bevacizumab treatment of recurrent gliosarcoma in which alternative aetiologies of haemorrhage were excluded, to our knowledge the first such case in the English language literature. This adverse event is compatible with the known molecular mechanisms of bevacizumab and clinicians should be cognisant of the potential risk of CNS haemorrhage until larger studies are available to quantify this risk. (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - January 23, 2015 Category: Neurosurgery Source Type: research

A new approach to integrate toxicity grade and repeated treatment cycles in the analysis and reporting of phase I dose-finding trials
Conclusions Dedicated methods can be used to analyze toxicities from all cycles of treatment. They do not delay accrual and should be integrated in the analysis and reporting of phase I dose-finding trials. (Source: Annals of Oncology)
Source: Annals of Oncology - January 23, 2015 Category: Cancer & Oncology Authors: Doussau, A., Thiebaut, R., Geoerger, B., Schoffski, P., Floquet, A., Le Deley, M. C., Mathoulin-Pelissier, S., Rizzo, E., Fumoleau, P., Le Tourneau, C., Paoletti, X. Tags: clinical trials Source Type: research

Tomato thymidine kinase-based suicide gene therapy for malignant glioma—an alternative for Herpes Simplex virus-1 thymidine kinase
Tomato thymidine kinase-based suicide gene therapy for malignant glioma—an alternative for Herpes Simplex virus-1 thymidine kinase Cancer Gene Therapy advance online publication, January 23 2015. doi:10.1038/cgt.2014.76 Authors: H Stedt, H Samaranayake, J Kurkipuro, G Wirth, L S Christiansen, T Vuorio, A-M Määttä, J Piškur & S Ylä-Herttuala (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - January 23, 2015 Category: Cancer & Oncology Authors: H StedtH SamaranayakeJ KurkipuroG WirthL S ChristiansenT VuorioA-M MäättäJ PiškurS Ylä-Herttuala Source Type: research

Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma
In conclusion, lncRNA MALAT1 plays an important role on glioma progression and prognosis and may serve as a convictive prognostic biomarker for glioma patients. (Source: Tumor Biology)
Source: Tumor Biology - January 23, 2015 Category: Cancer & Oncology Source Type: research

Use of Hormonal Contraceptives Linked to Brain CancerUse of Hormonal Contraceptives Linked to Brain Cancer
A Danish nationwide case-control study has found an association between hormonal contraceptive use and risk for glioma. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 22, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Taking the pill ‘may increase the risk of brain cancer’
Regularly using the contraceptive pill increases the relative risk of developing rare brain gliomas, according to a new Danish study in British Journal of Clinical Pharmacology. Researchers stressed that the absolute risk remained small. Daily Mail (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 22, 2015 Category: Endocrinology Source Type: news

Long-term use of hormonal contraceptives is associated with an increased risk of brain tumors
(Wiley) Taking a hormonal contraceptive for at least five years is associated with a possible increase in a young woman's risk of developing a rare tumor, glioma of the brain. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2015 Category: Cancer & Oncology Source Type: news

Taking contraceptive pill for five years doubles risk of brain tumour, warn scientists
Female sex hormones used in the contraceptive pill may increase the risk of some cancer types, scientists think (Source: Telegraph Health)
Source: Telegraph Health - January 22, 2015 Category: Consumer Health News Tags: brain tumour is the pill safe contraceptive pill glioma Source Type: news

Hormonal Contraception Use in Younger Women Linked to Glioma Risk (FREE)
By Kelly Young Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM Use of hormonal contraceptives is associated with elevated risk for brain glioma in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 22, 2015 Category: Primary Care Source Type: news

In vivo micro-CT imaging of untreated and irradiated orthotopic glioblastoma xenografts in mice: capabilities, limitations and a comparison with bioluminescence imaging
Abstract Small animal imaging is of increasing relevance in biomedical research. Studies systematically assessing the diagnostic accuracy of contrast-enhanced in vivo micro-CT of orthotopic glioma xenografts in mice do not exist. NOD/SCID/γc−/− mice (n = 27) underwent intracerebral implantation of 2.5 × 106 GFP-Luciferase-transduced U87MG cells. Mice underwent bioluminescence imaging (BLI) to detect tumor growth and afterwards repeated contrast-enhanced (300 µl Iomeprol i.v.) micro-CT imaging (80 kV, 75 µAs, 360° rotation, 1,000 projections, 33 s scan time, resolution 40 × 40 × 53 µm, 0.5...
Source: Journal of Neuro-Oncology - January 22, 2015 Category: Cancer & Oncology Source Type: research

Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas.
Authors: Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM Abstract Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter methylation in gliomas. Patients without WNK2 exhibited poor prognosis, and its downregulation was associated with increased glioma cell invasion. Here we showed that MMP2 expression and activity are increased in glioma cell lines that do no...
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Microfoci of malignant progression in diffuse low-grade gliomas: towards the creation of an intermediate grade in glioma classification?
Abstract Low-grade gliomas (GII) inescapably progress to high-grade gliomas (GIII). The duration of this transition is highly variable between patients and reliable predictive markers do not exist. We noticed in a subset of cases of GII, obtained by awake neurosurgery, the presence of microfoci with high cellular density, high vascular density, or minimal endothelial proliferation, which we called GII+. Our aim was to investigate whether these foci display immunohistochemical and molecular characteristics similar to GIII and whether their presence is correlated to poor prognosis. We analyzed cell proliferation, hy...
Source: Virchows Archiv - January 21, 2015 Category: Pathology Source Type: research

Serum macrophage‐derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - January 21, 2015 Category: Cancer & Oncology Authors: Mi Zhou, Paige M. Bracci, Lucie S. McCoy, George Hsuang, Joseph L. Wiemels, Terri Rice, Shichun Zheng, Karl T. Kelsey, Margaret R. Wrensch, John K. Wiencke Tags: Tumor Immunology Source Type: research

Fluorescent Cancer-Selective Alkylphosphocholine Analogs for Intraoperative Glioma Detection
CONCLUSION: CLR1501 (green) and CLR1502 (near infrared) are novel tumor-selective fluorescent agents for discriminating tumor from normal brain. CLR1501 exhibits a tumor-to-brain fluorescence ratio similar to that of 5-ALA, whereas CLR1502 has a superior tumor-to-brain fluorescence ratio. This study demonstrates the potential use of CLR1501 and CLR1502 in fluorescence-guided tumor surgery. ABBREVIATIONS: APC, alkylphosphocholine 5-ALA, 5-aminolevulinic acid GBM, glioblastoma multiforme GSC, glioblastoma stem cell GTR, gross total resection HGG, high-grade glioma PBS, phosphate-buffered solution PpIX, protoporphyrin IX T:N,...
Source: Neurosurgery - January 20, 2015 Category: Neurosurgery Tags: Research-Laboratory: Editor's Choice Source Type: research

Correction: Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma
No description available (Source: Molecular Cancer)
Source: Molecular Cancer - January 20, 2015 Category: Cancer & Oncology Authors: Ye SongQisheng LuoHao LongZheng HuTianshi QueXi'an ZhangZhiyong LiGang WangLiu YiZhen LiuWeiYi FangSongtao Qi Source Type: research

Decreased miRNA-637 is an unfavorable prognosis marker and promotes glioma cell growth, migration and invasion via direct targeting Akt1
, X Zhang, W Fang & S Qi (Source: Oncogene)
Source: Oncogene - January 19, 2015 Category: Cancer & Oncology Authors: T QueY SongZ LiuS ZhengH LongZ LiY LiuG WangY LiuJ ZhouX ZhangW FangS Qi Source Type: research

Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma
F Proust, P Gandolfo, F Morin & H Castel (Source: Oncogene)
Source: Oncogene - January 19, 2015 Category: Cancer & Oncology Authors: C LecointreL DesruesJ E JoubertN PerzoP-O GuichetV Le JoncourC BruléM ChabbertR LeducL PrézeauA LaquerrièreF ProustP GandolfoF MorinH Castel Source Type: research

Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis
Glioblastoma multiforme (GBM) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of glioma stem cells (GSCs) have been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, CD133-positive glioma cells have been shown to represent the sub-population that confers glioma radioresistance and suggested to be the source of tumor recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating GBM patients. (So...
Source: The Journal of Nutritional Biochemistry - January 19, 2015 Category: Biochemistry Authors: Thanh-Tuan Huynh, Chien-Min Lin, Wei-Hwa Lee, Alexander T.H. Wu, Yen-Kuang Lin, Yuh-Feng Lin, Chi-Tai Yeh, Liang-Shun Wang Source Type: research

MiR125a‐5p acting as a novel Gab2 suppressor inhibits invasion of glioma
This study is the first to focus on miR125a‐5p, which was predicted to regulate Gab2 with directly targeting the 3′ un‐translated region (3′UTR) of Gab2 and could inhibit migration and invasion of glioma cells by mediating Gab2 to affect cytoskeleton rearrangement and matrix metalloproteinases expression. Interestingly, further evaluation revealed that the miR125a‐5p promoter was hypermethylated and that attenuating promoter methylation was sufficient to up‐regulate miR125a‐5p expression in glioma cells. Additionally, we reported that miR125a‐5p was down‐regulated in glioma as well as statistical analysis...
Source: Molecular Carcinogenesis - January 18, 2015 Category: Molecular Biology Authors: Lei Sun, Baogang Zhang, Yuqing Liu, Lihong Shi, Hongli Li, Shijun Lu Tags: Research Article Source Type: research

Diagnostic significance of intraoperative ultrasound contrast in evaluating the resection degree of brain glioma by transmission electron microscopic examination.
Conclusions : Intraoperative ultrasound contrast was of a high sensitivity and specificity in evaluating the excision degree of tumor. The consistency of the residual tumor rate detected, respectively, by ultrasound contrast and TEM examination was of medium consistency. The application of intraoperative ultrasound contrast can improve the resection rate of brain glioma. PMID: 25591560 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - January 17, 2015 Category: Journals (General) Authors: Yu SQ, Wang JS, Chen SY, Liu XM, Li Y, Ding YM, Li XY, Sun YL, Chen H Tags: Chin Med J (Engl) Source Type: research

Impact of 1p/19q Codeletion and Histology on Outcomes of Anaplastic Gliomas Treated With Radiation Therapy and Temozolomide
In this report, we present our institutional data on the clinical outcomes of radiation therapy (RT) plus temozolomide (RT + TMZ) for anaplastic gliomas, stratified by histology and 1p/19q codeletion. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 17, 2015 Category: Radiology Authors: Christina K. Speirs, Joseph R. Simpson, Clifford G. Robinson, Todd A. DeWees, David D. Tran, Gerry Linette, Michael R. Chicoine, Ralph G. Dacey, Keith M. Rich, Joshua L. Dowling, Eric C. Leuthardt, Gregory J. Zipfel, Albert H. Kim, Jiayi Huang Tags: Clinical Investigation Source Type: research

EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner
Publication date: Available online 15 January 2015 Source:Stem Cell Reports Author(s): Sung-Hak Kim , Kaushal Joshi , Ravesanker Ezhilarasan , Toshia R. Myers , Jason Siu , Chunyu Gu , Mariko Nakano-Okuno , David Taylor , Mutsuko Minata , Erik P. Sulman , Jeongwu Lee , Krishna P.L. Bhat , Anna Elisabetta Salcini , Ichiro Nakano Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb r...
Source: Stem Cell Reports - January 17, 2015 Category: Stem Cells Source Type: research

Overturning dogma to open the black box of DIPG
We report and comment on medical innovations and advances – from bench to bedside – touching on scientific, business and policy issues. Our ranks include science writers, physicians, lab researchers, market analysts and others inside and outside the hospital. By Tom Ulrich You can't advance the care of a disease that you can't study. And for 40 years, that was the case with a rare, uniformly fatal pediatric brain tumor called diffuse intrinsic pontine glioma, or DIPG. Boston Children's HospitalNews Well, Vector Blog, Big Data, Blogread more (Source: Mass Device)
Source: Mass Device - January 16, 2015 Category: Medical Equipment Authors: MassDevice Tags: Vector Blog Source Type: news

Laser Interstitial Thermal Therapy for Recurrent HG Glioma?Laser Interstitial Thermal Therapy for Recurrent HG Glioma?
While promising in some cases, this commentary questions whether there is sufficient evidence to support laser interstitial thermal therapy as a general alternative to resection for high-grade glioma. Neurosurgical Focus (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 16, 2015 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Ubiquitin ligase Siah1 promotes the migration and invasion of human glioma cells by regulating HIF-1α signaling under hypoxia.
We report here, that Siah1 was expressed highly in human glioma tissues compared with its expression in normal brain tissues and was correlated with advanced tumor status and stage. The knockdown of Siah1 by short-hairpin RNA severely suppressed the migration and invasion of human glioma U251 cells under hypoxia, while overexpression of Siah1 promoted it. Furthermore, we demonstrated that the glioma cell migration and invasion under hypoxia mediated by Siah1 was achieved by reducing the stability of PHD3, which protected the HIF-1α from degradation. These findings suggest that Siah1 plays important roles in the migration ...
Source: Oncology Reports - January 16, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma.
In conclusion, PARP inhibition targets PTEN-deficient GBM cells through accentuation of SAC repression and aggravation of HR deficiency, leading to the induction of genomic instability and eventually deriving to mitotic catastrophe (MC); the inhibition of PARP and co-treatment with an inhibitor of pro-survival pathways strongly retarded in vivo gliomagenesis. PMID: 25576921 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - January 16, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Angiocentric Glioma: A treatable cause of epilepsy: Report of a rare case
Aanchal Kakkar, Mehar Chand Sharma, Vaishali Suri, Seema Kaushal, Sarat P Chandra, Ajay Garg, Chitra SarkarNeurology India 2014 62(6):677-679 (Source: Neurology India)
Source: Neurology India - January 16, 2015 Category: Neurology Authors: Aanchal KakkarMehar Chand SharmaVaishali SuriSeema KaushalSarat P ChandraAjay GargChitra Sarkar Source Type: research

Primary central nervous system histiocytic sarcoma mimicking glioma
Jiwei Bai, Guang Li, Mi Shen, Dali Sui, Song LinNeurology India 2014 62(6):684-685 (Source: Neurology India)
Source: Neurology India - January 16, 2015 Category: Neurology Authors: Jiwei BaiGuang LiMi ShenDali SuiSong Lin Source Type: research

Chordoid glioma: Case report and review of the literature
CONCLUSION: Efficient treatment of chordoid glioma depends upon radical surgical resection. Based on the reviewed data, which showed high morbi-mortality rates for this kind of tumor, we recommend a more conservative treatment approach. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 16, 2015 Category: Surgery Source Type: research

Incidental diagnosis of diffuse intrinsic pontine glioma in children
Children with diffuse intrinsic pontine glioma (DIPG) have a short onset, rapidly progressive neurologic decline before diagnosis. Therefore, incidental diagnosis of such an aggressive cancer is counterintuitive, yet our experience shows DIPG may occur as part of a spectrum of incidentally diagnosed pediatric brain cancers. Although children with incidentally diagnosed DIPG may experience a longer survival, it remains a potentially deadly cancer despite treatment with radiotherapy. Histologic confirmation is warranted when feasible in such patients to confirm diagnosis. Moreover, recent advances in genome‐wide analyses m...
Source: Pediatric Blood and Cancer - January 16, 2015 Category: Cancer & Oncology Authors: Karen D. Wright, Noah D. Sabin, Daniel Cheuk, RenéY. McNall‐Knapp, Sheila A. Shurtleff, Amar Gajjar, Alberto Broniscer Tags: Brief Report Source Type: research

Accuracy of direct magnetic resonance imaging-guided placement of drug infusion cannulae.
Abstract An intraoperative MRI (iMRI)-compatible system has been developed for direct placement of convection-enhanced delivery (CED) cannulae using real-time imaging. To establish the precision and feasibility of this technology, the authors analyzed findings in patients who underwent direct iMRI CED cannula placement. Three consecutive patients underwent iMRI-guided placement of CED infusion cannulae (6 cannulae) for treatment of diffuse intrinsic brainstem glioma (2 patients) or Parkinson's disease (1 patient). Convective infusion cannulae were guided to the target using the ClearPoint iMRI-based navigation plat...
Source: Journal of Neurosurgery - January 16, 2015 Category: Neurosurgery Authors: Chittiboina P, Heiss JD, Lonser RR Tags: J Neurosurg Source Type: research

Economics of Malignant Gliomas: A Critical Review [Original Contributions]
Conclusion: With increased chemotherapy use for malignant glioma, the paradigm for treatment and associated out-of-pocket and total medical costs continue to evolve. Larger out-of-pocket costs may influence the choice of chemotherapeutic agents, the economic implications of which should be evaluated prospectively. (Source: Journal of Oncology Practice)
Source: Journal of Oncology Practice - January 16, 2015 Category: Cancer & Oncology Authors: Raizer, J. J., Fitzner, K. A., Jacobs, D. I., Bennett, C. L., Liebling, D. B., Luu, T. H., Trifilio, S. M., Grimm, S. A., Fisher, M. J., Haleem, M. S., Ray, P. S., McKoy, J. M., DeBoer, R., Tulas, K.-M. E., Deeb, M., McKoy, J. M. Tags: Policy Original Contributions Source Type: research

Endothelial-monocyte-activating polypeptide II induces rat C6 glioma cell apoptosis via the mitochondrial pathway.
Abstract The present study was performed to examine whether Endothelial-monocyte-activating polypeptide II (EMAP II) could inhibit glioma growth by inducing rat brain glioma C6 cells apoptosis. The results revealed that the EMAP II decreased cell viability of rat C6 glioma cells in a time-dependent manner. Apoptotic proportion was increased gradually after EMAP II. EMAP II induced the decrease in mitochondrial membrane potential and the release of cytochrome c into the cytosol, followed by activation of caspase-9 and caspase-3. Meanwhile, EMAP II-induced apoptosis was accompanied by an increase of reactive oxygen s...
Source: Biochemical and Biophysical Research communications - January 16, 2015 Category: Biochemistry Authors: Liu LB, Xie H, Xue YX, Liu YH, Li Z, Wang P Tags: Biochem Biophys Res Commun Source Type: research

Evaluation of lactate detection using selective multiple quantum coherence in phantoms and brain tumours
This study presents the use of a selective homonuclear multiple quantum coherence transfer sequence (SelMQC‐CSI), at 1.5 T, to better quantify lactate in the presence of lipids. Work performed on phantoms showed good lactate detection (49%) and lipid suppression (98%) efficiencies. To evaluate the method in the brain, the sequence was tested on a group of 23 patients with treated brain tumours, either glioma (N = 20) or secondary metastases in the brain (N = 3). Here it was proved to be of use in determining lactate concentrations in vivo. Lactate was clearly seen in SelMQC spectra of glioma, even in the presen...
Source: NMR in Biomedicine - January 15, 2015 Category: Radiology Authors: L. M. Harris, N. Tunariu, C. Messiou, J. Hughes, T. Wallace, N. M. DeSouza, M. O. Leach, G. S. Payne Tags: Research article Source Type: research

Tumor suppressor miR-181c attenuates proliferation, invasion, and self-renewal abilities in glioblastoma
Glioblastoma multiforme (GBM) is well known for its aggressiveness, but the underlying mechanisms are unclear, limiting the treatment. In the present study, we showed that miR-181c, a commonly downregulated miRNA in GBM reported by several miRNA profiles, was associated with the mesenchymal subtype of GBM and predicted the outcome for patients from a GBM cohort (n=518) obtained from The Cancer Genome Atlas database. A multivariate analysis showed that miR-181c was an independent prognostic indicator for GBM patients. Quantitative reverse transcription PCR showed that miR-181c was expressed poorly in neurospheres of glioma ...
Source: NeuroReport - January 15, 2015 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Clinicopathological and Prognostic Significance of CD133 in Glioma Patients: A Meta-Analysis
Abstract In recent years, CD133 has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic value of CD133 in glioma patients remains controversial. Therefore, we conducted a systematic meta-analysis to evaluate the correlation of CD133 with World Health Organization (WHO) grade, age, gender, overall survival (OS), and progression-free survival (PFS) in glioma patients. Eligible studies on this subject were included, and then pooled odd ratios (ORs) and hazard ratios (HRs) with 95 % confidence intervals (95 % CIs) were estimated. Publication bias was assessed by t...
Source: Molecular Neurobiology - January 15, 2015 Category: Neurology Source Type: research

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model
Journal of Medicinal ChemistryDOI: 10.1021/jm501829f (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - January 14, 2015 Category: Chemistry Authors: Ilaria Paterni, Simone Bertini, Carlotta Granchi, Tiziano Tuccinardi, Marco Macchia, Adriano Martinelli, Isabella Caligiuri, Giuseppe Toffoli, Flavio Rizzolio, Kathryn E. Carlson, Benita S. Katzenellenbogen, John A. Katzenellenbogen and Filippo Minutolo Source Type: research

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model
Journal of Medicinal ChemistryDOI: 10.1021/jm501829f (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - January 14, 2015 Category: Chemistry Authors: Ilaria Paterni, Simone Bertini, Carlotta Granchi, Tiziano Tuccinardi, Marco Macchia, Adriano Martinelli, Isabella Caligiuri, Giuseppe Toffoli, Flavio Rizzolio, Kathryn E. Carlson, Benita S. Katzenellenbogen, John A. Katzenellenbogen and Filippo Minutolo Source Type: research

Glioma trials and viral tribulations: can anything be concluded from non-controlled trials?
The highest standards of clinical evidence are phase III randomised, double-blind, controlled clinical trials. Their significance to clinical medicine is given theoretically by the fact that patients as well as doctors are blind to the treatment and no bias can subvert patients’ assignments to either treatment arm. Their practical significance is established by the fact that a large majority of potential treatments that are apparently effective in early phase trials fail in phase III trials. The reasons for failure of phase III trials are multiple: from the clinical translation of potential therapies of doubtful sign...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Lowenstein, P. R., Castro, M. G. Tags: Immunology (including allergy), Neurooncology, CNS cancer, Neuropathology Editorial commentaries Source Type: research

Cytomegalovirus and glioma: putting the cart before the horse
In 1908, Oluf Bang and Vilhelm Ellerman laid the foundation for theory of oncoviruses by demonstrating that the avian erythroblastosis (a form of chicken leukaemia) could be transmitted by cell-free extracts. Since then, it has been shown very convincingly that viruses can directly cause several human cancers by various mechanisms. Epidemiological data imply that viruses are the second most important risk factor for cancer development in humans, exceeded only by tobacco consumption. Although the ability of certain viruses (hepatitis B and C, human papillomavirus, etc) to cause cancer has been time tested and proven scienti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Dey, M., Ahmed, A. U., Lesniak, M. S. Tags: Neurooncology, CNS cancer Neuro-oncology Source Type: research

Subcortical language and non-language mapping in awake brain surgery: the use of multimodal tests
Conclusion Administration of multimodal tests during subcortical DES such as the experimental QMT may facilitate identification of eloquent pathways leading to avoidance of permanent neurological impairments. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - January 14, 2015 Category: Neurosurgery Source Type: research

Performance of SPECT in the differential diagnosis of glioma recurrence from radiation necrosis
Publication date: February 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 2 Author(s): Hui Zhang , Li Ma , Chen Wu , Bai-nan Xu Radiation necrosis (RN) may be a confounder in the diagnosis of glioma recurrence. Several functional imaging techniques, including single photon emission computed tomography (SPECT) and positron emission tomography (PET), have been used to differentiate RN from glioma recurrence. However, to our knowledge the efficacy of SPECT has not been evaluated quantitatively. This meta-analysis evaluated the diagnostic ability of SPECT in differentiating glioma recurrence from RN. PubMed a...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Human cytomegalovirus viral load in tumor and peripheral blood samples of patients with malignant gliomas
Publication date: February 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 2 Author(s): Eldar Priel , Anton Wohl , Michal Teperberg , Dvora Nass , Zvi R. Cohen Malignant gliomas are the most common primary brain tumors in adults. The disease has no known etiology, progresses rapidly, and is fatal despite current therapies. Human cytomegalovirus (HCMV) is a beta herpes virus that is trophic for glial cells and infects 50% to 90% of the adult human population. HCMV-mediated disease in immunosuppressed patients has highlighted the possible role of this virus in the development of other diseases, particularly ...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Interhemispheric transfalcine approach and awake cortical mapping for resection of peri-atrial gliomas associated with the central lobule
We present the first case of a right medial posterior frontoparietal oligoastrocytoma that was resected through the interhemispheric transfalcine approach using awake cortical and subcortical mapping. Through a contralateral frontoparietal craniotomy, we excised a section of the falx and exposed the contralateral medial hemisphere. Cortical stimulation allowed localization of the supplementary motor cortex, and suprathreshold stimulation mapping excluded the primary motor cortex corresponding to the leg area. Gross total tumor resection was accomplished without any intraoperative or postoperative deficits. Awake cortical m...
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Low grade glioma in an adult patient with Sotos syndrome
Publication date: February 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 2 Author(s): Elisavet Theodoulou , Atik Baborie , Michael D. Jenkinson Sotos syndrome is a rare overgrowth syndrome with an increased risk of tumorigenesis. To our knowledge we report the first case of astrocytoma in an adult patient with Sotos syndrome and describe the clinical course. (Source: Journal of Clinical Neuroscience)
Source: Journal of Clinical Neuroscience - January 14, 2015 Category: Neuroscience Source Type: research

Bullseye: Targeting cancer stem cells to improve the treatment of gliomas by repurposing Disulfiram
This article is protected by copyright. All rights reserved. (Source: Stem Cells)
Source: Stem Cells - January 14, 2015 Category: Stem Cells Authors: J. Triscott, M.R. Pambid, S.E. Dunn Tags: Cancer stem cells Source Type: research