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Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration
Conclusions: Taken together, our results from the present and earlier studies clearly demonstrate that alpha9beta1 integrin-mediated cell migration utilizes the iNOS pathway, and inhibition of the migratory potential of glioma cells by simultaneous knockdown of MMP-9 and uPAR could be attributed to the reduced alpha9beta1 integrin and iNOS levels. (Source: BMC Cancer)
Source: BMC Cancer - December 11, 2013 Category: Cancer & Oncology Authors: Thompson ZhuangBharath ChelluboinaShivani PonnalaKiran VelpulaAzeem RehmanChandramu ChettyEleonora ZakharianJasti RaoKrishna Veeravalli Source Type: research
MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway
Conclusions: The present data indicates that miR-92b directly regulate cell proliferation and apoptosis by targeting DKK3 and act as prognostic factors for glioma patients. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2013 Category: Research Authors: Qifeng LiKe ShenYang ZhaoChenkai MaJianwen LiuJie Ma Source Type: research
Single-cell resolution in high-resolution synchrotron X-ray CT imaging with gold nanoparticles
Gold nanoparticles are excellent intracellular markers in X-ray imaging. Having shown previously the suitability of gold nanoparticles to detect small groups of cells with the synchrotron-based computed tomography (CT) technique both ex vivo and in vivo, it is now demonstrated that even single-cell resolution can be obtained in the brain at least ex vivo. Working in a small animal model of malignant brain tumour, the image quality obtained with different imaging modalities was compared. To generate the brain tumour, 1 × 105 C6 glioma cells were loaded with gold nanoparticles and implanted in the right cerebral hemisphere...
Source: Journal of Synchrotron Radiation - December 11, 2013 Category: Physics Authors: Schültke, E.Menk, R.Pinzer, B.Astolfo, A.Stampanoni, M.Arfelli, F.Harsan, L.-A.Nikkhah, G. Tags: animal model brain tumour high-resolution imaging gold nanoparticles X-ray CT research papers Source Type: research
MicroRNA-21 expression is associated with overall survival in patients with glioma
Conclusions: Our data show that miR-21 may be a candidate independent marker for gliomas, especially those with high pathological grades, and this could also be a potential therapeutic target for molecular glioma therapy.Virtual slide: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1445749171109834. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - December 10, 2013 Category: Pathology Authors: Lin WuGang LiDayun FengHuaizhou QinLi GongJian ZhangZhiguo Zhang Source Type: research
Membrane‐type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases
We previously reported that glioma cells induce the expression of membrane‐type 1 metalloproteinase (MT1‐MMP or MMP‐14) in tumor‐associated microglia/macrophages and promote tumor growth, whereas MMP‐14 expression in microglia under physiological conditions is very low. Here, we show that the increase in MMP‐14 expression is also found in microglia/macrophages associated with neurodegenerative and neuroinflammatory pathologies in mouse models as well as in human biopsies or post‐mortem tissue. We found that microglial/macrophage MMP‐14 expression was upregulated in Alzheimer's disease tissue, in active lesi...
Source: Journal of Neuroscience Research - December 9, 2013 Category: Neuroscience Authors: Anika Langenfurth, Jan Leo Rinnenthal, Katyayni Vinnakota, Vincent Prinz, Anne‐Sophie Carlo, Christine Stadelmann, Volker Siffrin, Susann Peaschke, Matthias Endres, Frank Heppner, Rainer Glass, Susanne A. Wolf, Helmut Kettenmann Tags: Research Article Source Type: research
Enhancement of antitumor activity by combination of tumor lysate-pulsed dendritic cells and celecoxib in a rat glioma model.
Abstract Using dendritic cell (DC)-based vaccines for treatment of gliomas has emerged as a meaningful and feasible treatment approach for inducing long-term survival, but this approach so far has failed to generate significant clinical responses. In the present study, we demonstrated that glioma lysate-pulsed DCs in combination with celecoxib, a selective cyclooxygenase 2 (COX-2) inhibitor, showed more significantly enhanced antitumor activity with increased apoptosis of tumor cells, reduced neovascularization, and developed a strong cytotoxic T lymphocyte (CTL) response in tumor-bearing rats. Celecoxib may reduce...
Source: Oncology Research - December 8, 2013 Category: Cancer & Oncology Authors: Zhang H, Tian M, Xiu C, Wang Y, Tang G Tags: Oncol Res Source Type: research
Krüppel‐Like Factor 4 Regulates Blood‐Tumor Barrier Permeability via ZO‐1, Occludin and Claudin‐5
In this study, we sought to investigate the role of KLF4 in regulation of BTB function as well as the potential molecular mechanisms. Quantitative RT‐PCR, western blot, and immunofluorescence assays demonstrated that KLF4 was down‐regulated in the glioma endothelial cells (GECs) which were obtained through endothelial cells co‐cultured with glioma cells. Short hairpin RNA targeting KLF4 impaired the integrity of BTB detected by trans‐endothelial electric resistance assay, and meanwhile reduced the expression of ZO‐1, occludin and claudin‐5, demonstrated by quantitative RT‐PCR, western blot, and immunofluoresc...
Source: Journal of Cellular Physiology - December 7, 2013 Category: Cytology Authors: Jun Ma, Ping Wang, Yunhui Liu, Lini Zhao, Zhen Li, Yixue Xue Tags: Original Research Article Source Type: research
Serological Identification of URGCP as a Potential Biomarker for Glioma.
CONCLUSION: We identified a potential new biomarker of GBM, URGCP. The findings indicate that URGCP is immunogenic in human GBM and suggest its potential use as diagnostic and immunotherapeutic for GBM patients. PMID: 24308561 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - December 6, 2013 Category: Neuroscience Authors: Chen LC, Zhang HY, Qin ZY, Wang Y, Mao Y, Yao Y, Zhou LF Tags: CNS Neurosci Ther Source Type: research
Researcher studies pediatric brain stem tumors
Children's National researcher, Javad Nazarian, PhD, authored a new study entitled, "Comparative Multidimensional Molecular Analyses of Pediatric Diffuse Intrinsic Pontine Glioma Reveals Distinct Molecular Subtypes." The study found, for the first time, two distinct subtypes in pediatric diffuse intrinsic pontine gliomas (DIPG). It was published online in Acta Neuropathologica, a leading journal on pathology and pathogenesis of neurological disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 5, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Comprehensive analysis of the functional microRNA-mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression
Glioma is the most common and fatal primary brain tumour with poor prognosis; however, the functional roles of miRNAs in glioma malignant progression are insufficiently understood. Here, we used an integrated approach to identify miRNA functional targets during glioma malignant progression by combining the paired expression profiles of miRNAs and mRNAs across 160 Chinese glioma patients, and further constructed the functional miRNA–mRNA regulatory network. As a result, most tumour-suppressive miRNAs in glioma progression were newly discovered, whose functions were widely involved in gliomagenesis. Moreover, three miR...
Source: Nucleic Acids Research - December 5, 2013 Category: Research Authors: Li, Y., Xu, J., Chen, H., Bai, J., Li, S., Zhao, Z., Shao, T., Jiang, T., Ren, H., Kang, C., Li, X. Tags: Genomics Methods Online Source Type: research
Low Incidence of Pseudoprogression by Imaging in Newly Diagnosed Glioblastoma Patients Treated With Cediranib in Combination With Chemoradiation.
Conclusion.Administration of a VEGF inhibitor during and after CRT modifies the expression of PsP by imaging. PMID: 24309981 [PubMed - as supplied by publisher] (Source: The Oncologist)
Source: The Oncologist - December 5, 2013 Category: Cancer & Oncology Authors: Pinho MC, Polaskova P, Kalpathy-Cramer J, Jennings D, Emblem KE, Jain RK, Rosen BR, Wen PY, Sorensen AG, Batchelor TT, Gerstner ER Tags: Oncologist Source Type: research
Mammalian diaphanous-related formin 1 is required for motility and invadopodia formation in human U87 glioblastoma cells.
In conclusion, our data demonstrate that mDRF1 is highly expressed in human glioma tissue. The knockdown of mDRF1 in U87 MG cells led to a sharp decline in their invasive and metastatic ability, which effectively reduced the spread of glioma cells into the surrounding areas. To our knowledge, this is the first report showing that mDRF1 is a promising target for the treatment of malignant gliomas. PMID: 24317603 [PubMed - as supplied by publisher] (Source: International Journal of Molecular Medicine)
Source: International Journal of Molecular Medicine - December 5, 2013 Category: Molecular Biology Authors: Li Z, Xu Y, Zhang C, Liu X, Jiang L, Chen F Tags: Int J Mol Med Source Type: research
Kinex Pharma gets FDA orphan drug status for glioma drug
US-based Kinex Pharmaceuticals has received orphan drug designation from the US Food and Drug Administration (FDA) for its dual src/pre-tubulin inhibitor 'KX02' to treat gliomas, which are the most common and aggressive form of brain cancer. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - December 4, 2013 Category: Pharmaceuticals Source Type: news
Children's National researcher authors study on pediatric brain stem tumors
(Children's National Medical Center) Children's National researcher, Javad Nazarian, Ph.D., authored a new study entitled, "Comparative Multidimensional Molecular Analyses of Pediatric Diffuse Intrinsic Pontine Glioma Reveals Distinct Molecular Subtypes." The study found, for the first time, two distinct subtypes in pediatric diffuse intrinsic pontine gliomas. It was published online in Acta Neuropathologica, a leading journal on pathology and pathogenesis of neurological disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 3, 2013 Category: Global & Universal Source Type: news
Vemurafenib in pediatric patients with BRAFV600E mutated high‐grade gliomas
We present three pediatric patients with BRAFV600E mutant high‐grade gliomas treated by vemurafenib on a nominative authorization level at our institution. One patient with anaplastic ganglioglioma experienced confirmed partial tumor response and significant clinical improvement and she is alive 20 months after start of treatment. A second patient with ganglioglioma responded transiently to re‐introduction of vemurafenib after immunotherapy. Pharmacokinetic studies suggest that maximum concentration and exposure of vemurafenib at steady‐state is dose‐dependent and similar in children to that reported in adults. The...
Source: Pediatric Blood and Cancer - December 3, 2013 Category: Cancer & Oncology Authors: Francisco Bautista, Angelo Paci, Veronique Minard‐Colin, Christelle Dufour, Jacques Grill, Ludovic Lacroix, Pascale Varlet, Dominique Valteau‐Couanet, Birgit Geoerger Tags: Brief Report Source Type: research
Effect of α, β momorcharin on viability, caspase activity, cytochrome c release and on cytosolic calcium levels in different cancer cell lines.
This study investigated the anti-cancer effects and the cellular mechanisms of action of α, β momocharin (200-800 μM) on 1321N1, Gos-3, U87-MG, Sk Mel, Corl-23 and Weri Rb-1 cancer cell lines compared to normal healthy L6 muscle cell line measuring cell viability using MTT assay kit, Caspase-3 and 9 activities, cytochrome c release and intracellular free calcium concentrations [Ca(2+)]i. The results show that α, β momorcharin can evoke significant dose-dependent (P < 0.05; Student's t test) decreases in the viability (increases in cell death) of 1321N1, Gos-3, U87-MG, Sk Mel, Corl-23 and Weri Rb-1 cancer cell li...
Source: Molecular and Cellular Biochemistry - December 3, 2013 Category: Biochemistry Authors: Manoharan G, Jaiswal SR, Singh J Tags: Mol Cell Biochem Source Type: research
PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas.
CONCLUSIONS: These data are the first to link PID1 to cancer and suggest that PID1 may have a tumor inhibitory function in these pediatric and adult brain tumors. PMID: 24300787 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - December 3, 2013 Category: Cancer & Oncology Authors: Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol A, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S Tags: Clin Cancer Res Source Type: research
Down-modulation of Bis reduces the invasive ability of glioma cells induced by TPA through NF-κB mediated activation of MMP-9.
Abstract Bcl-2 interacting cell death suppressor (Bis) has been shown to have anti-apoptotic and anti-stress functions. Recently, increased Bis expression was reported to correlate with the glioma aggressiveness. Here, we investigated the effect of Bis knockdown on the acquisition of the invasive phenotype of A172 glioma cells, induced by 12-O-Tetradecanoylphorbol-13-acetate (TPA) using a Transwell assay. Bis knockdown resulted in a significant decrease in the migration and invasion of A172 cells. Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expressio...
Source: BMB Reports - December 1, 2013 Category: Biochemistry Authors: Lee YD, Cui MN, Yoon HH, Kim HY, Oh IH, Lee JH Tags: BMB Rep Source Type: research
Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1.
Abstract Polypyrimidine tract-binding protein 1 (PTBP1) and its brain-specific homologue, PTBP2, are associated with pre-mRNAs and influence pre-mRNA processing, as well as mRNA metabolism and transport. They play important roles in neural differentiation and glioma development. In our study, we detected the expression of the two proteins in glioma cells and predicted that they may be sumoylated using SUMOplot analyses. We confirmed that PTBP1 and PTBP2 can be modified by SUMO1 with co-immunoprecipitation experiments using 293ET cells transiently co-expressing SUMO1 and either PTBP1 or PTBP2. We also found that SUM...
Source: BMB Reports - December 1, 2013 Category: Biochemistry Authors: Han W, Wang L, Yin B, Peng X Tags: BMB Rep Source Type: research
Cytotoxic and apoptotic functions of licofelone on rat glioma cells.
Abstract Gliomas are the largest group of central nervous system tumors and despite of clinical treatments death rate is very high. Inhibition of both cyclooxygenase and lipoxygenase pathways that take role in arachidonic acid metabolism prevents cancer development and induces apoptosis. One of the most promising compounds that blocks both of these pathways is licofelone. Using colchicine and 5-fluorouracil as positive controls, we questioned whether licofelone affects the survival of rat glioma cell line (C6) and induces apoptosis in vitro. After growing the cells in culture, we determined viability with MT, apopt...
Source: Acta Biologica Hungarica - December 1, 2013 Category: Biology Authors: Kus G, Oztopcu-Vatan P, Uyar R, Kabadere S Tags: Acta Biol Hung Source Type: research
Mathematical modeling of brain glioma growth using modified reaction–diffusion equation on brain MR images
Abstract: In this paper, a modified reaction–diffusion model is proposed for modeling the diffusion of brain glioma cells. Unlike the other models, a weighted parameter is introduced, which balances the diffusion coefficient of the grey and white matters. Anisotropic characteristics of the model are represented. A local region similarity measure (local Bhattacharyya distance) determines the weighted parameter. Experimental results demonstrate the effectiveness and accuracy of the modified reaction diffusion equation with a weighted parameter for real brain glioma MR images. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - December 1, 2013 Category: Bioinformatics Authors: Jianjun Yuan, Lipei Liu, Qingmao Hu Source Type: research
Identification of EGFRvA, a New Isoform of EGFR
In this study, we report the identification of a naturally occurring and widely expressed EGFR isoform termed EGFRvA, which substitutes a Ser/Thr-rich peptide for part of the carboxyl-terminal regulatory domain of the receptor. Intriguingly, EGFRvA expression relates more closely to histopathologic grade and poor prognosis in patients with glioma. Ectopic expression of EGFRvA in cancer cells conferred a higher invasive capacity than EGFR in vitro and in vivo. Mechanistically, EGFRvA stimulated expression of STAT3, which upregulated heparin-binding EGF (HB-EGF). Reciprocally, HB-EGF stimulated phosphorylation of EGFRvA at Y...
Source: Cancer Research - December 1, 2013 Category: Cancer & Oncology Authors: Zhou, M., Wang, H., Zhou, K., Luo, X., Pan, X., Shi, B., Jiang, H., Zhang, J., Li, K., Wang, H.-M., Gao, H., Lu, S., Yao, M., Mao, Y., Wang, H.-Y., Yang, S., Gu, J., Li, C., Li, Z. Tags: Tumor and Stem Cell Biology Source Type: research
Facile synthesis of ultra-small hybrid silica spheres for enhanced penetration of 3D glioma spheroids
Chem. Commun., 2013, Accepted ManuscriptDOI: 10.1039/C3CC48416E, CommunicationMeihua Yu, Surajit Karmakar, Jie Yang, Hongwei Zhang, Yannan Yang, Peter Thorn, Chengzhong YuA facile approach has been developed to prepare ultra-small hybrid silica spheres with a diameter of about 10 nm, which show highly enhanced penetration ability in 3D glioma spheroids compared...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - November 29, 2013 Category: Chemistry Authors: Meihua Yu Source Type: research
Delayed leptomeningeal and subependymal seeding after multiple surgeries for supratentorial diffuse low-grade gliomas in adults.
Conclusions Cerebrospinal fluid dissemination of DLGG is a rare but possible event. It can occur throughout the progression of WHO Grade II oligodendrogliomas, oligoastrocytomas, and astrocytomas, regardless of 1p19q status. This complication seems to appear in patients who have undergone multiple incomplete resections. Salvage therapy can be considered in patients with good neurological status. However, LMSS is associated with a decreased overall survival. Therefore, this rare entity deserves further multicenter studies to better understand its pathophysiology and to adapt therapeutic strategies. PMID: 24286144 [PubMe...
Source: Journal of Neurosurgery - November 29, 2013 Category: Neurosurgery Authors: Alvarez de Eulate-Beramendi S, Rigau V, Taillandier L, Duffau H Tags: J Neurosurg Source Type: research
Letter to the Editor: CD97 and glioma invasion.
PMID: 24286141 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 29, 2013 Category: Neurosurgery Authors: Huang LC, Hueng DY Tags: J Neurosurg Source Type: research
Is there pseudoprogression in secondary glioblastomas?
CONCLUSIONS: Based on this small series of sGBM patients treated with CRTx (concomitantly or sequentially) the frequency of PP appears to be very low in sGBM, even in those patients with methylated MGMT promoter or IDH mutations. Our results highlight the differences between primary glioblastomas and sGBM in particular as they relate to PP. PMID: 24267971 [PubMed - in process] (Source: Health Physics)
Source: Health Physics - November 27, 2013 Category: Physics Authors: Juratli TA, Engellandt K, Lautenschlaeger T, Geiger KD, von Kummer R, Cerhova J, Chakravarti A, Krex D, Schackert G Tags: Int J Radiat Oncol Biol Phys Source Type: research
Disruption of bimanual movement by unilateral subcortical electrostimulation
ConclusionsThis is the first evidence of bilateral negative motor responses elicited by unilateral subcortical stimulation. Such findings support the existence of a bilateral cortico‐subcortical network connecting the premotor cortices, basal ganglia, and spinal cord, involved in the control of bimanual coordination. A better understanding of this modulatory motor circuit may have important implications in fundamental neurosciences as well as in brain surgery. Hum Brain Mapp, 2013. © 2013 Wiley Periodicals, Inc. (Source: Human Brain Mapping)
Source: Human Brain Mapping - November 27, 2013 Category: Neurology Authors: Fabien Rech, Guillaume Herbet, Sylvie Moritz‐Gasser, Hugues Duffau Tags: Research Article Source Type: research
Prognostic Value of a Nine-Gene Signature in Glioma Patients Based on mRNA Expression Profiling.
CONCLUSION: This 9-gene-signature prediction model provided a more accurate predictor of prognosis that denoted patients with high risk score have poor outcome. Moreover, these risk models based on defined molecular profiles showed the considerable prospect in personalized cancer management. PMID: 24279471 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - November 27, 2013 Category: Neuroscience Authors: Bao ZS, Li MY, Wang JY, Zhang CB, Wang HJ, Yan W, Liu YW, Zhang W, Chen L, Tao J Tags: CNS Neurosci Ther Source Type: research
Glutamate transporters in the biology of malignant gliomas.
Abstract Malignant gliomas are relentless tumors that offer a dismal clinical prognosis. They develop many biological advantages that allow them to grow and survive in the unique environment of the brain. The glutamate transporters system x c (-) and excitatory amino acid transporters (EAAT) are emerging as key players in the biology and malignancy of these tumors. Gliomas manipulate glutamate transporter expression and function to alter glutamate homeostasis in the brain, which supports their own growth, invasion, and survival. As a consequence, malignant cells are able to quickly destroy and invade surrounding no...
Source: Cellular and Molecular Life Sciences : CMLS - November 27, 2013 Category: Cytology Authors: Robert SM, Sontheimer H Tags: Cell Mol Life Sci Source Type: research
Children's National researcher receives grant for Pediatric Brain Cancer Research
(Children's National Medical Center) Javad Nazarian, Ph.D., a researcher with Children's Research Institute at Children's National, is the recipient of a $99,979 grant from the DIPG Collaborative for his proposal entitled, "Comparative Proteomic and RNA Sequencing of DIPGs." The DIPG Collaborative is a leading association of foundations funding pediatric diffuse intrinsic pontine glioma (DIPG) research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 27, 2013 Category: Global & Universal Source Type: news
Gross total but not incomplete resection of glioblastoma prolongs survival in the era of radiochemotherapy
Conclusions The value of incomplete resection remains questionable. If GTR cannot be safely achieved, biopsy only might be used as an alternative surgical strategy. (Source: Annals of Oncology)
Source: Annals of Oncology - November 26, 2013 Category: Cancer & Oncology Authors: Kreth, F. - W., Thon, N., Simon, M., Westphal, M., Schackert, G., Nikkhah, G., Hentschel, B., Reifenberger, G., Pietsch, T., Weller, M., Tonn, J. - C., for the German Glioma Network Tags: brain tumors Source Type: research
Fatty acid binding protein 7 as a marker of glioma stem cells
In this study, using a newly developed anti‐FABP7 antibody and patient‐derived GSC lines, we evaluated the expression of FABP7 in GSCs. Using immunocytochemistry, Western blotting, and qPCR analyses, FABP7 was found to be highly enriched in GSCs and its localization was found in cytosol and nuclei. FABP7 expression was significantly downregulated in differentiated GSCs induced by the addition of serum. In the glioma surgical specimens, FABP7 was highly expressed in the majority of glioblastoma. Double immunostaining for FABP7 and Sox2 showed that FABP7+Sox2+ tumor cells were significantly increased in glioblastoma (gra...
Source: Pathology International - November 26, 2013 Category: Pathology Authors: Yusuke Morihiro, Yuki Yasumoto, Linda Koshy Vaidyan, Hirokazu Sadahiro, Tomoyuki Uchida, Akinori Inamura, Kazem Sharifi, Makoto Ideguchi, Sadahiro Nomura, Nobuko Tokuda, Shoji Kashiwabara, Aya Ishii, Eiji Ikeda, Yuji Owada, Michiyasu Suzuki Tags: Original Article Source Type: research
The effect and mechanism of CXCR4 silencing on metastasis suppression of human glioma u87 cell line.
In this study, we found that CXCR4 silencing could suppress U87 cells invasion and adhesion potential, production of TGF-β1, IL-6, and IL-8, and blocked the G0/G1 phase of the cell cycle. We also found that CXCR4 silencing could up-regulate the mRNA and protein expression of p53, p21, and E-cadherin, and down-regulate the mRNA and protein expression of CD44 and MMP-2/-9. Meanwhile, CXCR4 silencing could decrease the phosphorylation of p-AKT and transcription activity of NF-κB promoter, and increased the phosphorylation of PTEN. The results provided a new research basis for the further study of CXCR4 gene, the screening o...
Source: Anatomical Record - November 24, 2013 Category: Anatomy Authors: Zhu Y, Yang P, Zhang X, Zhang L, Cui G, Wang Q, Lv L, Zhang Y, Xin X, Yan T, Zhao M, Zhang N Tags: Anat Rec (Hoboken) Source Type: research
Is There Pseudoprogression in Secondary Glioblastomas?
Conclusions: Based on this small series of sGBM patients treated with CRTx (concomitantly or sequentially) the frequency of PP appears to be very low in sGBM, even in those patients with methylated MGMT promoter or IDH mutations. Our results highlight the differences between primary glioblastomas and sGBM in particular as they relate to PP. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 23, 2013 Category: Radiology Authors: Tareq A. Juratli, Kay Engellandt, Tim Lautenschlaeger, Kathrin D. Geiger, Rüdiger von Kummer, Jana Cerhova, Arnab Chakravarti, Dietmar Krex, Gabriele Schackert Tags: Central Nervous System Tumors Source Type: research
An extremely rare case of glioblastoma multiforme of the spinal cord.
We report a case of intramedullary glioblastoma multiforme in a young man and describe the diagnostic difficulties and devastating progression of the entity. PMID: 24247921 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 22, 2013 Category: Universities & Medical Training Authors: Randakevičienė G, Gleiznienė R, Basevičius A, Lukoševičius S Tags: Medicina (Kaunas) Source Type: research
Clinical application of perfusion computed tomography in neurosurgery.
Conclusions Perfusion CT provides quantitative and qualitative data that can add diagnostic and prognostic value in a number of neurosurgical disorders, and also help with clinical decision making. With emerging new technical developments in PCT, such as characterization of blood-brain barrier permeability and whole-brain PCT, this technique is expected to provide more and more insight into the pathophysiology of many neurosurgical conditions. PMID: 24266541 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 22, 2013 Category: Neurosurgery Authors: Huang AP, Tsai JC, Kuo LT, Lee CW, Lai HS, Tsai LK, Huang SJ, Chen CM, Chen YS, Chuang HY, Wintermark M Tags: J Neurosurg Source Type: research
Bevacizumab May Bring Back Vision in Optic Pathway GliomasBevacizumab May Bring Back Vision in Optic Pathway Gliomas
Bevacizumab treatment of children with optic pathway gliomas (OPG) appears to produce marked recovery of vision, according to a new report of four cases. Reuters Health Information (Source: Medscape Ophthalmology Headlines)
Source: Medscape Ophthalmology Headlines - November 21, 2013 Category: Opthalmology Tags: Hematology-Oncology News Source Type: news
Accelerated hazards model based on parametric families generalized with Bernstein polynomials
Summary A transformed Bernstein polynomial that is centered at standard parametric families, such as Weibull or log‐logistic, is proposed for use in the accelerated hazards model. This class provides a convenient way towards creating a Bayesian nonparametric prior for smooth densities, blending the merits of parametric and nonparametric methods, that is amenable to standard estimation approaches. For example optimization methods in SAS or R can yield the posterior mode and asymptotic covariance matrix. This novel nonparametric prior is employed in the accelerated hazards model, which is further generalized to time‐depe...
Source: Biometrics - November 21, 2013 Category: Biotechnology Authors: Yuhui Chen, Timothy Hanson, Jiajia Zhang Tags: ORIGINAL ARTICLE Source Type: research
Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway
Conclusion: Our data indicate that integrin-targeting factors endostatin and tumstatin act additively by inhibiting glioblastoma growth via reduction of vessel density but also directly by affecting proliferation and viability of tumor cells. Treatment with the ES + Tum-combination activates the PRLR pro-proliferative pathway in glioblastoma. Future work will show whether the prolactin signaling pathway represents an additional target to improve therapeutic strategies in this entity. (Source: Molecular Cancer)
Source: Molecular Cancer - November 20, 2013 Category: Cancer & Oncology Authors: Leticia Oliveira-FerrerJasmin WellbrockUdo BartschEva Murga PenasJessica HauschildMarianne KlokowCarsten BokemeyerWalter FiedlerGunter Schuch Source Type: research
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy
Glioblastoma (GB), World Health Organization Grade 4 glioma, is the most common malignant primary brain tumour with an annual incidence of 12,943 cases in the United States . It is a tumour of the elderly people with a median age of onset of 64 years, although children and young adults are also affected. GB is associated with a poor prognosis; despite best treatment, most community‐based patients will not survive 1 year . Cures are rare and overall survival rates at 2 and 5 years are 26–48% and 12%, respectively, in highly selected, contemporary, clinical trial eligible patients . For protocol eligible US patients, ...
Source: International Journal of Clinical Practice - November 19, 2013 Category: Internal Medicine Authors: M. C. Chamberlain Tags: Perspective Source Type: research
Association of Metabolite Concentrations and Water Diffusivity in Normal Appearing Brain Tissue with Glioma Grade
CONCLUSIONSThis study supports previous observations of altered tissue metabolism and water diffusion in normal‐appearing white matter while additionally finding differences of metabolite values in gray matter and an association with tumor grade. (Source: Journal of Neuroimaging)
Source: Journal of Neuroimaging - November 19, 2013 Category: Radiology Authors: Andrew A. Maudsley, Bhaswati Roy, Rakesh K. Gupta, Sulaiman Sheriff, Rishi Awasthi, Meng Gu, Nuzhat Husain, Sudipa Mohakud, Sanjay Behari, Daniel M. Spielman Tags: Clinical Investigative Study Source Type: research
Functional outcome measures for NF1-associated optic pathway glioma clinical trials
Conclusions: The use of these key functional endpoints will be essential for evaluating the efficacy of future OPG clinical trials. (Source: Neurology)
Source: Neurology - November 18, 2013 Category: Neurology Authors: Fisher, M. J., Avery, R. A., Allen, J. C., Ardern-Holmes, S. L., Bilaniuk, L. T., Ferner, R. E., Gutmann, D. H., Listernick, R., Martin, S., Ullrich, N. J., Liu, G. T., For the REiNS International Collaboration Tags: All Neuro-ophthalmology, Visual loss, Clinical trials Methodology/study design, Neurofibromatosis RESPONSE EVALUATION IN NEUROFIBROMATOSIS AND SCHWANNOMATOSIS (REINS) Source Type: research
Isolated acquired primary gusto-lacrimal reflex from a brainstem glioma
We describe a patient with gusto-lacrimal reflex without other evidence of facial nerve dysfunction from a low-grade glioma infiltrating the brainstem and cerebellum. (Source: Neurology)
Source: Neurology - November 18, 2013 Category: Neurology Authors: Klein, A., Miller, N. R. Tags: Clinical neurology history, Clinical neurology examination, Primary brain tumor, Class I CLINICAL/SCIENTIFIC NOTES Source Type: research
ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299.
In this study, we identified ZFX as a promoter of lung cancer growth and migration in a NSCLC (non-small cell lung carcinoma) cell line H1299. ZFX knockdown caused proliferation inhibition determined by MTT assay and colony formation assay, G0/G1 arrest of cell cycle and slightly increased proportion of apoptotic cells assessed by flow cytometry assay, decreased population of migrating cells showed by wound-healing assay, increased cell senescence evidenced by senescence-associated β-galactosidase staining. ZFX knockdown also led to decreased proportion of tumor bearing mice and reduced mean tumor volume in a subcutaneous...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2013 Category: Pathology Authors: Li K, Zhu ZC, Liu YJ, Liu JW, Wang HT, Xiong ZQ, Shen X, Hu ZL, Zheng J Tags: Int J Clin Exp Pathol Source Type: research
Suppressing the malignant phenotypes of glioma cells by lentiviral delivery of small hairpin RNA targeting hypoxia-inducible factor-1α.
Abstract Hypoxic microenvironment of solid tumors is known to shape malignant phenotypes of cancer cells through the dimeric transcription factor hypoxia-inducible factor (HIF)-1. In the present study, the therapeutic effect of targeting α subunit of HIF-1 in glioma cells via lentiviral delivery of small hairpin RNA (shRNA) was evaluated. Data from quantitative real-time PCR and immunohistochemistry demonstrated that HIF-1α was progressively upregulated during the development of gliomas. Lentiviral shRNA targeting HIF-1α led to substantial loss of cell viability, G0/G1-phase cell cycle arrest, apoptosis, and imp...
Source: International Journal of Clinical and Experimental Pathology - November 16, 2013 Category: Pathology Authors: Dong CG, Wu WK, Feng SY, Yu J, Shao JF, He GM Tags: Int J Clin Exp Pathol Source Type: research
Quercetin Promotes Glioma Growth in a Rat Model.
Abstract We have previously demonstrated that quercetin (Quer), a polyphenol widely found in vegetables, decreased glioma cell growth in vitro. Here, we asked whether this compound could affect glioma growth in an in vivo rat glioma model. We found that daily intraperitoneal Quer (50 mg/kg) injections lead to a concentration of 0.15 μg of Quer per gram of brain tissue, which increased the tumor volume in a time dependent manner. We observed a small reduction in lymphocytic infiltration, a marker of good prognosis in gliomas that was accompanied by a small reduction in cell viability of peripheral T-cells. Moreover...
Source: Food and Chemical Toxicology - November 16, 2013 Category: Food Science Authors: Zamin LL, Filippi-Chiela EC, Vargas J, Demartini DR, Meurer L, Souza AP, Bonorino C, Salbego C, Lenz G Tags: Food Chem Toxicol Source Type: research
Neutrophils promote the malignant glioma phenotype through S100A4.
CONCLUSIONS: Collectively, these data suggest that increased recruitment of neutrophils during anti-VEGF therapy promotes glioma progression and may promote treatment resistance. Tumor progression with mesenchymal characteristics is partly mediated by S100A4, the expression of which is increased by neutrophil infiltration. Targeting granulocytes and S100A4 may be effective approaches to inhibit the glioma malignant phenotype and diminish antiangiogenic therapy resistance. PMID: 24240114 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 15, 2013 Category: Cancer & Oncology Authors: Liang J, Piao Y, Holmes LS, Fuller GN, Henry V, de Groot JF, Tiao N Tags: Clin Cancer Res Source Type: research
Surgery for insular low-grade glioma: predictors of postoperative seizure outcome.
Conclusions No or little postoperative seizure improvement occurs mainly in cases with a prevalent infiltrative tumor growth pattern, expressed by high ΔVT2T1 values, which consequently reflects a smaller EOR. PMID: 24236654 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 15, 2013 Category: Neurosurgery Authors: Ius T, Pauletto G, Isola M, Gregoraci G, Budai R, Lettieri C, Eleopra R, Fadiga L, Skrap M Tags: J Neurosurg Source Type: research
Sensitive in vivo cell detection using size-optimized superparamagnetic nanoparticles.
Abstract Magnetic nanoparticle (MNP) enabled cell visualization with magnetic resonance imaging (MRI) is currently an intensively studied area of research. In the present study, we have synthesized polyethylene glycolated (PEG) MNPs and validated their suitability as MR cell labeling agents in in vitro and in vivo experiments. The labeling of therapeutic potent mesenchymal stem cells (MSCs) with small core and large core MNPs was evaluated. Both MNPs were, in combination with a transfection agent, stably internalized into the MSCs and didn't show an effect on cell metabolism. The labeled cells showed high contras...
Source: Biomaterials - November 15, 2013 Category: Materials Science Authors: Trekker J, Leten C, Struys T, Lazenka VV, Argibay B, Micholt L, Lambrichts I, Van Roy W, Lagae L, Himmelreich U Tags: Biomaterials Source Type: research
Model for Concomitant Microdialysis Sampling of the Pons and Cerebral Cortex in Rhesus Macaques (Macaca mulatta).
Abstract Pediatric diffuse intrinsic pontine gliomas are aggressive brainstem tumors that fail to respond to treatment. We hypothesize that the protective features of the pons may hinder chemotherapeutic agents from entering pontine tissue compared with cortical brain tissue. To test this hypothesis, we developed a unique nonhuman primate model using microdialysis, a continuous in vivo extracellular sampling technique, to compare drug exposure concurrently in pontine tissue, cortical tissue, CSF, and plasma after intravenous administration of chemotherapeutic agents. The surgical coordinates and approach for microd...
Source: Comparative Medicine - November 14, 2013 Category: Zoology Authors: McCully CM, Pastakia D, Bacher J, Thomas ML, Steffen-Smith EA, Saleem K, Murphy RF, Walbridge S, Brinster L, Widemann BC, Warren KE Tags: Comp Med Source Type: research