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Downregulation of TRAP1 sensitizes glioblastoma cells to temozolomide chemotherapy through regulating metabolic reprogramming
Cancer cells preferentially use aerobic glycolysis to support growth, a metabolic alteration commonly referred to as the ‘Warburg effect.’ Here, we show that the tumor necrosis factor receptor-associated protein 1 (TRAP1) is crucial for the Warburg effect in human glioblastoma multiforme (GBM). In contrast to normal brain, GBMs show increased TRAP1 expression. We used both GBM cell lines and neurospheres derived from human GBM specimens to examine the effects of Knockdown of TRAP1 on GBM cell lines and glioma stem cells. We also used a neurosphere recovery assay that measured neurosphere formation at three time points ...
Source: NeuroReport - February 5, 2016 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

Diffusion tensor imaging suggests extrapontine extension of pediatric diffuse intrinsic pontine gliomas
Conclusion Reduction in fractional anisotropy and axial diffusivity and increase in radial diffusivity in diffuse intrinsic pontine glioma may reflect tumor extension along the corticospinal tracts as shown by histology. DTI may detect early tumor extrapontine tumor extension in diffuse intrinsic pontine glioma before it becomes apparent on conventional MRI sequences. (Source: European Journal of Radiology)
Source: European Journal of Radiology - February 5, 2016 Category: Radiology Source Type: research

Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma
Abstract Sonodynamic therapy (SDT) has shown great potential as an approach for cancer treatment, and hyperthermotherapy (HT) is also a promising cancer therapy. Here, we investigate whether HT could improve the efficacy of SDT and to make a preliminary exploration on potential mechanism. Xenograft tumor was established in nude mice model, and SNB19 and U87MG glioma cell lines were utilized for in vitro experiment. Alamar blue assay was performed to assess cell viability. Optical microscope was used to characterize the morphology changes of the glioma cells induced by SDT and HT treatments. Apoptotic rate, mitocho...
Source: Tumor Biology - February 4, 2016 Category: Cancer & Oncology Source Type: research

Notch Signaling Exhibits a Tumor Suppressor Function in Gliomas [Glioma]
Loss of Notch signaling enhances the growth of PDGF-driven Trp53-null forebrain tumors. (Source: Cancer Discovery)
Source: Cancer Discovery - February 4, 2016 Category: Cancer & Oncology Tags: Glioma Source Type: research

IDH Mutations Promote Glioma through Epigenetic Insulator Disruption [Glioma]
Disrupted CTCF binding at the PDGFRA boundary element enhances its expression, promoting glioma growth. (Source: Cancer Discovery)
Source: Cancer Discovery - February 4, 2016 Category: Cancer & Oncology Tags: Glioma Source Type: research

Consensus on Allergies and Glioma
Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention. Cancer Epidemiol Biomarkers Prev; 25(2); 282–90. ©2...
Source: Cancer Epidemiology Biomarkers and Prevention - February 4, 2016 Category: Cancer & Oncology Authors: Amirian, E. S., Zhou, R., Wrensch, M. R., Olson, S. H., Scheurer, M. E., Il'yasova, D., Lachance, D., Armstrong, G. N., McCoy, L. S., Lau, C. C., Claus, E. B., Barnholtz-Sloan, J. S., Schildkraut, J., Ali-Osman, F., Sadetzki, S., Johansen, C., Houlston, R Tags: Research Articles Source Type: research

Reply: The Optimal Dose of Hypofractionated Radiotherapy in Diffuse Intrinsic Pontine Glioma (DIPG)
(Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 3, 2016 Category: Cancer & Oncology Authors: Todd C. Hankinson, Arthur K. Liu Tags: LETTER TO THE EDITOR Source Type: research

Specific disgust processing in the left insula: New evidence from direct electrical stimulation
Publication date: Available online 1 February 2016 Source:Neuropsychologia Author(s): Costanza Papagno, Alberto Pisoni, Giulia Mattavelli, Alessandra Casarotti, Alessandro Comi, Francesca Fumagalli, Mirta Vernice, Enrica Fava, Marco Riva, Lorenzo Bello Neuropsychological and neuroimaging studies yielded controversial results concerning the specific role of the insula in recognizing the facial expression of disgust. To verify whether the insula has a selective role in facial disgust processing, emotion recognition was studied in thirteen patients during intraoperative stimulation of the insula in awake surgery p...
Source: Neuropsychologia - February 3, 2016 Category: Neurology Source Type: research

A Comprehensive Meta-analysis of Genetic Associations Between Key Polymorphic Loci in DNA Repair Genes and Glioma Risk
Abstract Genetic variants found in DNA repair genes (ERCC1, rs3212986; ERCC2, rs13181; ERCC4, rs1800067; ERCC5, rs17655; XRCC1, rs1799782, rs25487, rs25489; XRCC3, rs861539) have been reported to have an ambivalent association with the development of glioma. In the present study, a meta-analysis was conducted to confirm the relationship, taking heterogeneity of population into consideration. We analyzed 21 articles of 6 genes along with 8 single nucleotide polymorphisms (SNPs) (24,078 cases and 30,926 healthy individuals), which assessed the relationship between nucleotide excision, base excision, double-strand br...
Source: Molecular Neurobiology - February 3, 2016 Category: Neurology Source Type: research

Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
Stopping the growth of blood vessels in tumors is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. A team of researchers has developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 2, 2016 Category: Science Source Type: news

Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
(eLife ) Stopping the growth of blood vessels in tumors is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. A team of researchers have developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible. Their study is to be published in the journal eLife. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 2, 2016 Category: Cancer & Oncology Source Type: news

MicroRNA-132 cause apoptosis of glioma cells through blockade of the SREBP-1c metabolic pathway related to SIRT1
Conclusions The recovery of miR-132 resulted in caspase-dependent apoptotic death in glioma cells. MiR-132 that was newly discovered represents a newly targeting mechanism in treatment for glioma. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 2, 2016 Category: Drugs & Pharmacology Source Type: research

Targeting autophagy to sensitive glioma to temozolomide treatment
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies have found that TMZ treatment could induce autophagy, which contributes to therapy resistance in glioma. To enhance the benefit of TMZ in the treatment of glioblastomas, effective combination strategies are needed to sensitize glioblastoma cells to TMZ. In this regard, as autophagy could promote cell survival or autophagic cell death, modulating autophagy using a pharmacological inhibitor, such as chloroquine, or an i...
Source: Epidemiologic Perspectives and Innovations - February 2, 2016 Category: Epidemiology Authors: Yuanliang YanZhijie XuShuang DaiLong QianLunquan SunZhicheng Gong Source Type: research

Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma
Abstract During the last years, genome wide association studies have discovered common germline genetic variants associated with specific glioma subtypes. We aimed to study the association between these germline risk variants and tumor phenotypes, including copy number aberrations and protein expression. A total of 91 glioma patients were included. Thirteen well known genetic risk variants in TERT, EGFR, CCDC26, CDKN2A, CDKN2B, PHLDB1, TP53, and RTEL1 were selected for investigation of possible correlations with the glioma somatic markers: EGFR amplification, 1p/19q codeletion and protein expression...
Source: Journal of Neuro-Oncology - February 2, 2016 Category: Cancer & Oncology Source Type: research

Targeting autophagy to sensitive glioma to temozolomide treatment
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent high-grade gliomas. However, the efficacy of TMZ is often limited by the development of resistance. Recently, studies ... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 2, 2016 Category: Cancer & Oncology Authors: Yuanliang Yan, Zhijie Xu, Shuang Dai, Long Qian, Lunquan Sun and Zhicheng Gong Source Type: research

Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor
ConclusionThe effect of increasing T1w on the CEST signal in the tumor was mostly eliminated by the effect of increasing water content, and the observed APT‐weighted hyperintensity in the tumor should be dominated by the increased amide proton concentration. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 2, 2016 Category: Radiology Authors: Dong‐Hoon Lee, Hye‐Young Heo, Kai Zhang, Yi Zhang, Shanshan Jiang, Xuna Zhao, Jinyuan Zhou Tags: Full Paper Source Type: research

High Throughput Screening for Colorectal Cancer Specific Compounds.
Abstract The development of new anti-cancer therapeutic agents is necessary to improve antitumor efficacy and reduce toxicities. Here we report using a systematic anticancer drug screening approach we developed previously, to concurrently screen colon and glioma cancer cell lines for 2000 compounds with known bioactivity and 1920 compounds with unknown activity. The hits specific to each tumor cell line were then selected, and further tested with the same cells transfected with EGFP (Enhanced Green Fluorescent Protein) alone. By comparing the percentage of signal reduction from the same cells transfected with the s...
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2016 Category: Chemistry Authors: Xie J, Wang C, Gore JC Tags: Comb Chem High Throughput Screen Source Type: research

Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity [RESOURCE ARTICLE]
ABSTRACT Glioblastoma (GBM) is a deadly brain cancer, for which few effective drug treatments are available. Several studies have used zebrafish models to study GBM, but a standardized approach to modeling GBM in zebrafish was lacking to date, preventing comparison of data across studies. Here, we describe a new, standardized orthotopic xenotransplant model of GBM in zebrafish. Dose-response survival assays were used to define the optimal number of cells for tumor formation. Techniques to measure tumor burden and cell spread within the brain over real time were optimized using mouse neural stem cells as control transplants...
Source: DMM Disease Models and Mechanisms - February 2, 2016 Category: Biomedical Science Authors: Welker, A. M., Jaros, B. D., Puduvalli, V. K., Imitola, J., Kaur, B., Beattie, C. E. Tags: Cancer RESOURCE ARTICLE Source Type: research

Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis
Neoangiogenesis is a pivotal therapeutic target in glioblastoma. Tumor monitoring requires imaging methods to assess treatment effects and disease progression. Until now mapping of the tumor vasculature has been difficult. We have developed a combined magnetic resonance and optical toolkit to study neoangiogenesis in glioma models. We use in vivo magnetic resonance imaging (MRI) and correlative ultramicroscopy (UM) of ex vivo cleared whole brains to track neovascularization. T2* imaging allows the identification of single vessels in glioma development and the quantification of neovessels over time. Pharmacological VEGF inh...
Source: eLife - February 2, 2016 Category: Biomedical Science Authors: Breckwoldt, M. O., Bode, J., Kurz, F. T., Hoffmann, A., Ochs, K., Ott, M., Deumelandt, K., Krüwel, T., Schwarz, D., Fischer, M., Helluy, X., Milford, D., Kirschbaum, K., Solecki, G., Chiblak, S., Abdollahi, A., Winkler, F., Wick, W., Platten, M., Tags: Neuroscience Source Type: research

Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor.
CONCLUSION: The effect of increasing T1w on the CEST signal in the tumor was mostly eliminated by the effect of increasing water content, and the observed APT-weighted hyperintensity in the tumor should be dominated by the increased amide proton concentration. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. PMID: 26841096 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 2, 2016 Category: Radiology Authors: Lee DH, Heo HY, Zhang K, Zhang Y, Jiang S, Zhao X, Zhou J Tags: Magn Reson Med Source Type: research

Autoimmune Epilepsy
ABSTRACT: Purpose of Review: This review presents recent developments in the clinical features, immunologic basis, and treatment options for autoimmune encephalitis, seizures, and epilepsy. Recent Findings: In addition to the expansion of our knowledge on classic paraneoplastic limbic encephalitis with onconeural antibodies, recent years have witnessed the development of the category of encephalitis associated with antibodies directed toward neuronal surface antigens. Antibodies against the voltage-gated potassium channel are, in fact, directed toward an array of targets within a large molecular complex. The most common t...
Source: CONTINUUM: Lifelong Learning in Neurology - February 1, 2016 Category: Neurology Tags: Review Articles Source Type: research

Genetic cause identified in rare pediatric brain tumor
(Dana-Farber Cancer Institute) Researchers found a way of differentiating angiocentric gliomas from other low-grade pediatric brain tumors and developed a pathological test that will help children avoid unnecessary and potentially damaging additional therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 1, 2016 Category: Cancer & Oncology Source Type: news

uPAR as a Glioma Imaging Target
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2016 Category: Nuclear Medicine Authors: Hirata, K., Tamaki, N. Tags: Invited Perspectives Source Type: research

Urokinase-Type Plasminogen Activator Receptor as a Potential PET Biomarker in Glioblastoma
Conclusion: On the basis of our translational study, uPAR PET may be a highly promising imaging biomarker for glioblastoma. Further clinical exploration of uPAR PET in glioblastoma is therefore justified. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2016 Category: Nuclear Medicine Authors: Persson, M., Nedergaard, M. K., Brandt-Larsen, M., Skovgaard, D., Jorgensen, J. T., Michaelsen, S. R., Madsen, J., Lassen, U., Poulsen, H. S., Kjaer, A. Tags: Basic Science Investigations Source Type: research

Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma
Conclusion: These advancements warrant further development and integration of this technology with MRI for multimodal noninvasive tracking of therapeutic NSCs toward various brain malignancies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2016 Category: Nuclear Medicine Authors: Cheng, S.-H., Yu, D., Tsai, H.-M., Morshed, R. A., Kanojia, D., Lo, L.-W., Leoni, L., Govind, Y., Zhang, L., Aboody, K. S., Lesniak, M. S., Chen, C.-T., Balyasnikova, I. V. Tags: Basic Science Investigations Source Type: research

Separation and quantification of lactate and lipid at 1.3 ppm by diffusion‐weighted magnetic resonance spectroscopy
ConclusionDW‐MRS presents a new approach to separate and quantify spectrally overlapped molecules and/or macromolecules, such as lactate and lipid, by using the diffusivity difference associated with their different sizes or mobility within tissue microstructure. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 1, 2016 Category: Radiology Authors: Anna M. Wang, Gilberto K. K. Leung, Karrie M. Y. Kiang, Danny Chan, Peng Cao, Ed X. Wu Tags: Full Paper Source Type: research

Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma.
CONCLUSION: Our finding suggests that urinary 2-HG is increased among patients with IDH-mutant gliomas, and may represent a future surrogate, noninvasive biomarker to aid in diagnosis, prognosis, and management. IMPLICATIONS FOR PRACTICE: Patients with glioma who harbor mutations in isocitrate dehydrogenase genes showed selective elevation of the oncometabolite 2-hydroxyglutarate in the urine. Similar elevations were not identified in the serum or cerebrospinal fluid. 2-Hydroxyglutarate may serve as a useful, noninvasive biomarker to stratify patients newly diagnosed with glioma with regard to prognosis and management....
Source: The Oncologist - February 1, 2016 Category: Cancer & Oncology Authors: Fathi AT, Nahed BV, Wander SA, Iafrate AJ, Borger DR, Hu R, Thabet A, Cahill DP, Perry AM, Joseph CP, Muzikansky A, Chi AS Tags: Oncologist Source Type: research

Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy.
CONCLUSION: DW-MRS presents a new approach to separate and quantify spectrally overlapped molecules and/or macromolecules, such as lactate and lipid, by using the diffusivity difference associated with their different sizes or mobility within tissue microstructure. Magn Reson Med, 2016. © 2016 Wiley Periodicals, Inc. PMID: 26833380 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 1, 2016 Category: Radiology Authors: Wang AM, Leung GK, Kiang KM, Chan D, Cao P, Wu EX Tags: Magn Reson Med Source Type: research

Mesenchymal/radioresistant traits in granular astrocytomas: evidence from a combined clinical and molecular approach
ConclusionsOur findings show that specific morphological traits, such as a granular cell component, could represent useful features in guiding search for prognostic and predictive biomarkers, eventually amenable to targeted therapies (i.e. Met‐inhibitors aimed at reducing radio‐resistance).This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - February 1, 2016 Category: Pathology Authors: Rebecca Senetta, Marta Mellai, Claudia Manini, Isabella Castellano, Luca Bertero, Alessandra Pittaro, Davide Schiffer, Renzo Boldorini, Paola Cassoni Tags: Case report Source Type: research

MiR-129 triggers autophagic flux by regulating a novel Notch-1/ E2F7/Beclin-1 axis to impair the viability of human malignant glioma cells.
In conclusion, these findings identify a new function for miR-129 as a potent inducer of autophagy through a novel Notch-1/E2F7/Beclin-1 axis in glioma. PMID: 26824182 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - January 31, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Benefit from Bevacizumab and CCNU in Recurrent GBM Patients
In this study, we performed gene expression profiling (DASL and RNA-seq) of formalin-fixed, paraffin-embedded tumor material from participants of the BELOB trial to identify patients with recurrent GBM who benefitted most from beva+CCNU treatment. We demonstrate that tumors assigned to the IGS-18 or “classical” subtype and treated with beva+CCNU showed a significant benefit in progression-free survival and a trend toward benefit in overall survival, whereas other subtypes did not exhibit such benefit. In particular, expression of FMO4 and OSBPL3 was associated with treatment response. Importantly, the improved outcome ...
Source: Cancer Research - January 31, 2016 Category: Cancer & Oncology Authors: Erdem–Eraslan, L., van den Bent, M. J., Hoogstrate, Y., Naz–Khan, H., Stubbs, A., van der Spek, P., Bottcher, R., Gao, Y., de Wit, M., Taal, W., Oosterkamp, H. M., Walenkamp, A., Beerepoot, L. V., Hanse, M. C. J., Buter, J., Honkoop, A. H., va Tags: Clinical Studies Source Type: research

Hydroxamic Acid and Benzoic Acid-Based STAT3 Inhibitors
STAT3 offers an attractive target for cancer therapy, but small-molecule inhibitors with appealing pharmacologic properties have been elusive. Here, we report hydroxamic acid–based and benzoic acid–based inhibitors (SH5-07 and SH4-54, respectively) with robust bioactivity. Both inhibitors blocked STAT3 DNA-binding activity in vitro and in human glioma, breast, and prostate cancer cells and in v-Src–transformed murine fibroblasts. STAT3-dependent gene transcription was blocked along with Bcl-2, Bcl-xL, Mcl-1, cyclin D1, c-Myc, and survivin expression. Nuclear magnetic resonance analysis of STAT3-inhibitor complexes de...
Source: Cancer Research - January 31, 2016 Category: Cancer & Oncology Authors: Yue, P., Lopez-Tapia, F., Paladino, D., Li, Y., Chen, C.-H., Namanja, A. T., Hilliard, T., Chen, Y., Tius, M. A., Turkson, J. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

CacyBP/SIP inhibits Doxourbicin‐induced apoptosis of glioma cells due to activation of ERK1/2
Abstract Calcyclin‐binding protein or Siah‐1‐interacting protein (CacyBP/SIP) was previously reported to promote the proliferation of glioma cells. However, the effect of CacyBP/SIP on apoptosis of glioma is poorly understood. Here, our study shows that CacyBP/SIP plays a role in inhibiting doxorubicin (DOX) induced apoptosis of glioma cells U251 and U87. Overexpression of CacyBP/SIP obviously suppressed the DOX‐induced cell apoptosis. On the contrary, silencing of CacyBP/SIP significantly promoted it. Further investigation indicated that inhibition of apoptosis by CacyBP/SIP was relevant to its nuclear translocati...
Source: IUBMB Life - January 30, 2016 Category: Research Authors: Yuan Tang, Wenjian Zhan, Tong Cao, Tianjin Tang, Yong Gao, Zhichao Qiu, Chunling Fu, Fengyuan Qian, Rutong Yu, Hengliang Shi Tags: Research Communication Source Type: research

XBP1 silencing decreases glioma cell viability and glycolysis possibly by inhibiting HK2 expression
Abstract Glioma cells rely on glycolysis to obtain energy and sustain their survival under microenvironmental stress in vivo. The mechanisms of regulation of glycolysis in glioma cells are unclear. Signaling pathway mediated by the transcription factor X box-binding protein 1 (XBP1) is one of the most important pathways of unfolded protein response which is comprehensively activated in cancer cells upon the microenvironmental stress. Here we showed that XBP1 was significantly activated in glioma tissues in vivo. XBP1 silencing resulted in decreasing of glioma cell viability and ATP/lactate production under hypoxi...
Source: Journal of Neuro-Oncology - January 30, 2016 Category: Cancer & Oncology Source Type: research

Central Nervous System: Progress of Today and a Preview of Tomorrow
As cancer care has become ever increasingly personalized to patients, the laboratory is more than ever brought to the bedside in real time. What do we do now that the laboratory can provide clinicians with a plethora of molecular data on each patient in real time? How do physicians harness this often exponential flood of information to guide their recommendations for treatment? In a recent issue of the New England Journal of Medicine, 2 relevant articles pertaining to the molecular characterization of gliomas hit home on this point. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - January 29, 2016 Category: Radiology Authors: Helen A. Shih Tags: Feature Source Type: research

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Publication date: 28 January 2016 Source:Cell, Volume 164, Issue 3 Author(s): Michele Ceccarelli, Floris P. Barthel, Tathiane M. Malta, Thais S. Sabedot, Sofie R. Salama, Bradley A. Murray, Olena Morozova, Yulia Newton, Amie Radenbaugh, Stefano M. Pagnotta, Samreen Anjum, Jiguang Wang, Ganiraju Manyam, Pietro Zoppoli, Shiyun Ling, Arjun A. Rao, Mia Grifford, Andrew D. Cherniack, Hailei Zhang, Laila Poisson, Carlos Gilberto Carlotti, Daniela Pretti da Cunha Tirapelli, Arvind Rao, Tom Mikkelsen, Ching C. Lau, W.K. Alfred Yung, Raul Rabadan, Jason Huse, Daniel J. Brat, Norman L. ...
Source: Cell - January 29, 2016 Category: Cytology Source Type: research

A Synthetic Polymer Scaffold Reveals the Self‐Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche
This article is protected by copyright. All rights reserved. (Source: Stem Cells)
Source: Stem Cells - January 29, 2016 Category: Stem Cells Authors: Kouichi Tabu, Nozomi Muramatsu, Christian Mangani, Mei Wu, Rong Zhang, Taichi Kimura, Kazuo Terashima, Norihisa Bizen, Ryosuke Kimura, Wenqian Wang, Yoshitaka Murota, Yasuhiro Kokubu, Ikuo Nobuhisa, Tetsushi Kagawa, Issay Kitabayashi, Mark Bradley, Tetsuy Tags: Cancer Stem Cells Source Type: research

MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas
In conclusion, MIIP expressed higher in ESCCs than in paracancerous normal esophageal epithelia and was a positive, independent prognostic factor in resected ESCCs. (Source: Tumor Biology)
Source: Tumor Biology - January 29, 2016 Category: Cancer & Oncology Source Type: research

A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma
• HOXA11-AS, a novel lncRNA, is transcribed from the 5-prime end of the HOXA transcript and has a oncogenic function in glioma;• HOXA11-AS is a biomarker of progression and potentional therapeutic target for glioma;• HOXA11-AS promotes gliomagenesis by regulating cell cycle progression. (Source: Cancer Letters)
Source: Cancer Letters - January 29, 2016 Category: Cancer & Oncology Authors: Qixue Wang, Junxia Zhang, Yanwei Liu, Wei Zhang, Junhu Zhou, Ran Duan, Peiyu Pu, Chunsheng Kang, Lei Han Tags: Original Articles Source Type: research

Nerve growth factor improves visual loss in childhood optic gliomas: a randomized, double-blind, phase II clinical trial
This study evaluated the effects of nerve growth factor administration in protecting visual function in patients with optic pathway glioma-related visual impairment. A prospective randomized double-blind phase II clinical trial was conducted in 18 optic pathway glioma patients, aged from 2 to 23 years, with stable disease and severe visual loss. Ten patients were randomly assigned to receive a single 10-day course of 0.5 mg murine nerve growth factor as eye drops, while eight patients received placebo. All patients were evaluated before and after treatment, testing visual acuity, visual field, visual-evoked potentials, opt...
Source: Brain - January 29, 2016 Category: Neurology Authors: Falsini, B., Chiaretti, A., Rizzo, D., Piccardi, M., Ruggiero, A., Manni, L., Soligo, M., Dickmann, A., Federici, M., Salerni, A., Timelli, L., Guglielmi, G., Lazzareschi, I., Caldarelli, M., Galli-Resta, L., Colosimo, C., Riccardi, R. Tags: Neuro-oncology Original Articles Source Type: research

Bevacizumab changes vascular structure and modulates the expression of angiogenic factors in recurrent malignant gliomas
Abstract Bevacizumab (BV), a monoclonal antibody against vascular endothelial growth factor (VEGF), is currently used in the treatment of malignant glioma. To understand mechanisms of resistance to BV, we investigated morphological changes in tumor vessels and expression of angiogenic factors, such as VEGF, Flt-1, basic fibroblast growth factor (bFGF), and platelet-derived growth factor-BB (PDGF-BB), in four autopsied tumors after BV treatment. Three patients had glioblastomas; the fourth had a secondary glioblastoma that developed from a diffuse astrocytoma. BV was administered because of recurrence following the...
Source: Brain Tumor Pathology - January 29, 2016 Category: Neurology Source Type: research

Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling.
In conclusion, GGCT plays a critical role in glioma cell proliferation and may be a potential cancer therapeutic target. PMID: 26828272 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - January 29, 2016 Category: Biochemistry Authors: Shen SH, Yu N, Liu XY, Tan GW, Wang ZX Tags: Biochem Biophys Res Commun Source Type: research

[Impact of driving restrictions disclosure on quality of life of patients with a glial tumor: A prospective study].
CONCLUSION: Therefore, we believe that planning a specific psychological and social accompaniment of the patient in relation to driving restrictions is an undeniable necessity. PMID: 26832421 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - January 29, 2016 Category: Cancer & Oncology Authors: Bergot L, Cuchard S, Mazeaud S, Magro E, Seizeur R Tags: Bull Cancer Source Type: research

New way to identify brain tumor aggressiveness
A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 28, 2016 Category: Science Source Type: news

In precision medicine, pioneering young patient teaches veteran doctor
Allison Schablein seems an unlikely candidate to teach medicine to Mark Kieran. She’s an 8-year-old New Hampshire second grader who loves basketball, hip hop, acrobatic dancing and jewelry. He’s a pediatric neuro-oncologist with a PhD in molecular biology, not to mention decades of clinical and research experience. But teach Kieran, Allison does. In December 2012, Allison was diagnosed with metastatic anaplastic astrocytoma brain tumors — two on her brain stem, two on her spine, and three at the top of her head. She had surgery and chemotherapy — and for two months her tumors responded to therapy. Then treatment st...
Source: Thrive, Children's Hospital Boston - January 28, 2016 Category: Pediatrics Authors: Irene Sege Tags: Diseases & Conditions Our Patients’ Stories Research Brain tumor Dana-Farber/Boston Children's Cancer and Blood Disorders Center glioma Mark Kieran precision medicine Source Type: news

Multi-center study reveals unique subtypes of most common malignant brain cancer
(University of Texas M. D. Anderson Cancer Center) An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

New way to identify brain tumor aggressiveness
(Columbia University Medical Center) A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

International study describes new glioma subtypes
(Fundação de Amparo à Pesquisa do Estado de São Paulo) In an international study conducted in Brazil, researchers have identified new glioma subtypes on the basis of epigenetic profile. The new findings serve to stratify glioma patients more accurately and will contribute to an enhancement of treatment protocols. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

New molecular profiling for glioma
(University of Sao Paulo Scientific Outreach Unit) Cell publishes on its Jan. 28th edition the results of the largest study ever performed on the molecular profiles of gliomas -- that represent 80 percent of tumors of the central nervous system. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

The Glioma International Case-Control StudyThe Glioma International Case-Control Study
The Glioma International Case-Control Study, currently underway, aims to evaluate both environmental exposures and genetic variation to advance our understanding of glioma etiology. American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2016 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news