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Glioma

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Acute Toxicity Profile of Patients with Low-grade Gliomas and Meningiomas Receiving Proton Therapy
Conclusions:Our results suggest that proton therapy for patients with low-grade gliomas and meningiomas has a favorable acute toxicity profile—most patients experienced mild fatigue, headache, and insomnia that largely resolved by 1-month posttreatment. (Source: American Journal of Clinical Oncology - Current Table Of Contents)
Source: American Journal of Clinical Oncology - Current Table Of Contents - September 30, 2014 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Paclitaxel Poliglumex, Temozolomide, and Radiation for Newly Diagnosed High-grade Glioma: A Brown University Oncology Group Study
Conclusions:PPX could not be safely combined with temozolomide due to grade 4 hematologic toxicity. However, the favorable progression-free and overall survival suggest that PPX may enhance radiation for glioblastoma. A randomized study of single agent PPX/radiation versus temozolomide/radiation for glioblastoma without MGMT methylation is underway. (Source: American Journal of Clinical Oncology - Current Table Of Contents)
Source: American Journal of Clinical Oncology - Current Table Of Contents - September 30, 2014 Category: Cancer & Oncology Tags: Original Articles: Central Nervous System Source Type: research

Presenting symptoms of glioma in adults
ConclusionsThe main presenting symptoms of glioma in adults in the MRI age still are seizures and cognitive disorder. Patient age and tumor grade correlate positively with the incidence of cognitive disorder and patient age negatively with incidence of seizure as a presenting symptom. Headache is an uncommon manifestation and does not appear as a sole symptom. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - September 29, 2014 Category: Neurology Authors: J. P. Posti, M. Bori, T. Kauko, M. Sankinen, J. Nordberg, M. Rahi, J. Frantzén, V. Vuorinen, J. O. T. Sipilä Tags: Original Article Source Type: research

Raman molecular imaging of brain frozen tissue sections
The objective of this paper is to demonstrate the meaningful spatial molecular information provided by Raman spectroscopy for identification of regions of normal brain, necrosis, diffusely infiltrating glioma and solid glioblastoma (GBM). Five frozen section tissues (1 normal, 1 necrotic, 1 GBM, and 2 infiltrating glioma) were mapped in their entirety using a 300-µm-square step size. Smaller regions of interest were also mapped using a 25-µm step size. The relative concentrations of relevant biomolecules were mapped across all tissues and compared with adjacent hematoxylin and eosin-stained sections, allowing identificat...
Source: Journal of Neuro-Oncology - September 27, 2014 Category: Cancer & Oncology Source Type: research

MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells
In this study, we demonstrate that miR-136 is down-regulated in two cohorts of patients with glioma. Furthermore, the low-level expression of miR-136 is significantly associated with a more aggressive and/or poor prognostic phenotype of patients with gliomas. Both gain- and loss-of-function experiments showed that miR-136 expression can reverse cisplatin resistance and enhance the response to cisplatin treatment. Furthermore, we identified a novel direct target of miR-136, the E2F transcription factor 1 (E2F1) oncogene. Depletion of E2F1 recapitulated the tumor-suppressive functions of miR-136, whereas re-expression of E2F...
Source: Journal of Neuro-Oncology - September 27, 2014 Category: Cancer & Oncology Source Type: research

Effect of neoadjuvant temozolomide upon volume reduction and resection of diffuse low-grade glioma
We examined the impact of temozolomide upon volume reduction and resectability of LGG. We retrospectively identified 20 adult patients with biopsy-proven, deemed not totally resectable LGGs, treated initially with temozolomide. Volumetric 3D (calculated from serial FLAIR images) and 2D tumor measurements were obtained prior to treatment and at 3 months post-treatment. The anticipated extent of resection (EOR) at the 2 time points was measured based on anatomical limitations, calculated as: [(total tumor volume – unresectable tumor volume)/total tumor volume] ×100. Eloquent cortex, deep structures and corpus callosum we...
Source: Journal of Neuro-Oncology - September 27, 2014 Category: Cancer & Oncology Source Type: research

A RAD52 genetic variant located in a miRNA binding site is associated with glioma risk in Han Chinese
In conclusion, our results support the hypothesis that genetic variants influencing miRNA-mediated regulation of tumor suppressor genes or oncogenes may contribute glioma susceptibility. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - September 27, 2014 Category: Cancer & Oncology Source Type: research

Diffuse intrinsic pontine glioma biopsy: A single institution experience
Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. We performed a retrospective review on 22 consecutive cases of DIPG diagnosed from 2002 to 2012 at Children's Hospital of Michigan, 15 of which underwent biopsy. Transient new or worsening neurological deficits were observed in three of 15 cases following surgery. No surgery related mortality or permanent deficit was observed, and the mean overall survival was 10.4 ± 3.8 months. Undergoing biopsy did not adversely affect...
Source: Pediatric Blood and Cancer - September 27, 2014 Category: Cancer & Oncology Authors: Zhihong J. Wang, Latha Rao, Kanta Bhambhani, Kathy Miller, Janet Poulik, Deniz Altinok, Sandeep Sood Tags: Brief Report Source Type: research

Deep-Tissue Reporter-Gene Imaging with Fluorescence and Optoacoustic Tomography: A Performance Overview
Conclusions We show imaging capacity that can shift the visualization paradigm in biological discovery. The results are relevant not only to reporter gene imaging, but stand as cross-platform comparison for all methods imaging near infrared fluorescent contrast agents. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - September 26, 2014 Category: Molecular Biology Source Type: research

Mutational profiling of kinases in glioblastoma
Conclusions: The knowledge that at least 50% of glioblastoma tumors display mutational activation of the PI3K-AKT pathway should offer new opportunities for the rational development of therapeutic approaches for glioblastomas. However, due to the development of resistance mechanisms, kinase inhibition studies targeting the PI3K-AKT pathway for relapsing glioblastoma have mostly failed thus far. Other therapies should be investigated, targeting early events in gliomagenesis that involve both kinases and non-kinases. (Source: BMC Cancer)
Source: BMC Cancer - September 26, 2014 Category: Cancer & Oncology Authors: Fonnet BleekerSimona LambaCarlo ZanonRemco MolenaarTheo HulsebosDirk TroostAngela van TilborgW VandertopSieger LeenstraCornelis van NoordenAlberto Bardelli Source Type: research

Proton radiotherapy for pediatric tumors: review of first clinical results
Radiation therapy is a part of multidisciplinary management of several childhood cancers. Proton therapy is a new method of irradiation, which uses protons instead of photons. Proton radiation has been used safely and effectively for medulloblastoma, primitive neuro-ectodermal tumors, craniopharyngioma, ependymoma, germ cell intracranial tumors, low-grade glioma, retinoblastoma, rhabdomyosarcoma and other soft tissue sarcomas, Ewing?s sarcoma and other bone sarcomas. Moreover, other possible applications are emerging, in particular for lymphoma and neuroblastoma. Although both photon and proton techniques allow similar tar...
Source: Italian Journal of Pediatrics - September 26, 2014 Category: Pediatrics Authors: Barbara RombiSabina VennariniLorenzo VinanteDaniele RavanelliMaurizio Amichetti Source Type: research

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma
Abstract The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or epigenomic analyses is superior to histopathology for reflecting distinct biological groups, predicting outcomes and guiding therapy decisions has yet to be determined. Epigenome-wide DNA methylation analysis, using a platform which also allows the detection of copy-number aberrations, was performed in a cohort of 228 patients with anaplastic gliomas (astrocytomas, oligoastrocytomas, and oligodendrogliomas), including 115 patients of the NOA-04 ...
Source: Acta Neuropathologica - September 25, 2014 Category: Neurology Source Type: research

Histopathological spectrum of paediatric diffuse intrinsic pontine glioma: diagnostic and therapeutic implications
Abstract Diffuse intrinsic pontine glioma (DIPG) is the main cause of brain tumour-related death in children. In the majority of cases diagnosis is based on clinical and MRI findings, resulting in the scarcity of pre-treatment specimens available to study. Our group has developed an autopsy-based protocol to investigate the histologic and biologic spectrum of DIPG. This has also allowed us to investigate the terminal pattern of disease and gain a better understanding of what challenges we are facing in treating DIPG. Here, we review 72 DIPG cases with well documented clinical history and molecular data and descri...
Source: Acta Neuropathologica - September 25, 2014 Category: Neurology Source Type: research

Subventricular spread of diffuse intrinsic pontine glioma
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - September 25, 2014 Category: Neurology Source Type: research

Quantitative Longitudinal Evaluation of Diaschisis-Related Cerebellar Perfusion and Diffusion Parameters in Patients with Supratentorial Hemispheric High-Grade Gliomas After Surgery
In this study, we investigated the longitudinal evolution of diaschisis-related cerebellar perfusion and diffusion tensor-imaging (DTI) changes in patients after surgery for supratentorial brain tumors. Eight patients (M:F 5:3, age 8–22 years) who received surgery for supratentorial high-grade gliomas were evaluated. Initial MRI studies were performed 19–54 days postoperatively, with follow-ups at 2- to 3-month intervals. For each study, parametric maps of the cerebellum were generated and coregistered to T1-weighted images that had been previously segmented for cGM and cWM. Aggregate mean values of CBV, cerebral blo...
Source: The Cerebellum - September 25, 2014 Category: Neurology Source Type: research

Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
Summary The poor prognosis of children with high-grade glioma (HGG) and high-risk neuroblastoma, despite multidisciplinary therapeutic approaches, demands new treatments for these indications. F14512 is a topoisomerase II inhibitor containing a spermine moiety that facilitates selective uptake by tumor cells via the Polyamine Transport System (PTS) and increases topoisomerase II poisoning. Here, F14512 was evaluated in pediatric HGG and neuroblastoma cell lines. PTS activity and specificity were evaluated using a fluorescent spermine-coupled probe. The cytotoxicity of F14512, alone or in combination with ionizing...
Source: Investigational New Drugs - September 25, 2014 Category: Drugs & Pharmacology Source Type: research

Fluorescein-guided surgery for malignant gliomas: a review
In this report, we describe the results of a comprehensive review on the use of fluorescein in the surgical treatment of MGs. A comprehensive literature search and review for English-written articles concerning the use of fluorescein in the resection of MGs has been conducted. The search was executed through a PubMed literature search using the following keywords: malignant gliomas, glioblastomas, high-grade gliomas, YELLOW 560, total removal, dedicated filter, neurosurgery, brain tumors, intracranial tumors, and confocal microscopy. The literature search resulted in the retrieval of 412 evidence-based articles. Of these, ...
Source: Neurosurgical Review - September 25, 2014 Category: Neurosurgery Source Type: research

PDGFR‐β‐activated ACK1‐AKT signaling promotes glioma tumorigenesis
Abstract Aberrant PDGF‐PDGFR signaling and its effects on downstream effectors have been implicated in glioma development. A crucial AKT regulator, ACK1 (TNK2) has been shown to be a downstream mediator of PDGF signaling; however, the exact underlying mechanisms in gliomas remain elusive. Here, we report that in glioma cells, PDGFR‐β activation enhanced the interaction between ACK1 and AKT, resulting in AKT activation. PDGF treatment consistently promoted the formation of complexes containing PDGFR‐β and ACK1. Mutational analysis suggested that Y635 of ACK1 is a PDGFR‐β phosphorylation site and that the ACK1 Y63...
Source: International Journal of Cancer - September 25, 2014 Category: Cancer & Oncology Authors: Jiannan Zhang, Tao Chen, Qin Mao, Jinbo Lin, Jun Jia, Shanquan Li, Wenhao Xiong, Yingying Lin, Zhiqiang Liu, Xiaoyu Liu, Hailiang Zhao, Guisong Wang, Duo Zheng, Shuqi Qiu, Jianwei Ge Tags: Carcinogenesis Source Type: research

Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NF¿B) pathway
Conclusions: This work highlights the importance of GLI1 in the maintenance of characteristics of metastatic breast cancer stem cells. Remarkably, treatment with an inhibitor of the NF?B pathway reproducibly reduces GLI1 expression and protein levels. We further provide direct evidence for the binding of the NF?B subunit p65 to the GLI1 promoter in both EMT and claudin-low cell lines. Our results uncover crosstalk between NF?B and GLI1 signals and suggest that targeting these pathways may be effective against the claudin-low breast cancer subtype. (Source: Breast Cancer Research)
Source: Breast Cancer Research - September 25, 2014 Category: Cancer & Oncology Authors: Sierra ColavitoMike ZouQin YanDon NguyenDavid Stern Source Type: research

Potential serum biomarkers for glioblastoma diagnostic assessed by proteomic approaches
Conclusions: Proteomic technologies have been used to investigate the protein profile of glioblastoma patients and established several potential diagnostic biomarkers. While it is unlikely for a single biomarker to be highly effective for glioblastoma diagnostic, our data proposed an alternative and efficient approach by using a novel combination of multiple biomarkers. (Source: Proteome Science)
Source: Proteome Science - September 24, 2014 Category: Bioinformatics Authors: Ionela PopescuElena CodriciLucian AlbulescuSimona MihaiAna-Maria EnciuRadu AlbulescuCristiana Tanase Source Type: research

Erratum to: Quality appraisal of clinical practice guidelines on glioma
(Source: Neurosurgical Review)
Source: Neurosurgical Review - September 24, 2014 Category: Neurosurgery Source Type: research

Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation
In this study, we demonstrate that mitochondrial ATP-sensitive potassium channels (mtKATP channels) are overexpressed in glioma cells and are closely related to the malignancy grade and the overall survival of the patients. Importantly, we showed that mtKATP channels could control glioma radioresistance by regulating reactive oxygen species (ROS)-induced ERK activation. The inhibition of mtKATP channels suppresses glioma radioresistance by inhibiting ERK activation both in vitro and in vivo. These findings reveal the important roles of the mitochondria and mtKATP channels as key regulators in the radioresistance of glioma ...
Source: Molecular Neurobiology - September 24, 2014 Category: Neurology Source Type: research

The evolution of the anaplastic cerebellar liponeurocytoma: case report and review of the literature.
We report a case of a second recurrence of a cerebellar liponeurocytoma with increased proliferative and mitotic activity in which extensive immunohistochemical characterization and genetic profiling were performed. The tumor specimen was characterized in terms of genetic changes frequently associated with gliomas and medulloblastomas. Considering the low number of reported cases, the prognosis of cerebellar liponeurocytoma seems difficult to assess. Our case suggests the existence of different histological grades of cerebellar liponeurocytoma and its possible progression towards a dedifferentiated, malignant phenotype, wh...
Source: Clinical Neuropathology - September 24, 2014 Category: Pathology Authors: Radke J, Gehlhaar C, Lenze D, Capper D, Bock A, Heppner FL, Jödicke A, Koch A Tags: Clin Neuropathol Source Type: research

418o * temozolomide for 1p19q co-deleted and partially deleted gliomas
Conclusions: Upfront TMZ alone in 1p19q codeleted/incompletely deleted AOD was tolerated with favourable 5yr OS and may be a treatment option for this population.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: McNamara, M. G., Jiang, H., Lim Fat, M. J., Sahebjam, S., Kiehl, T. R., Karamchandani, J., Coire, C., Chung, C., Millar, B., Laperriere, N., Mason, W. Tags: CNS tumours Source Type: research

421P * CROSS-TALK BETWEEN THE NOTCH AND TRANSFORMING GROWTH FACTOR-{beta} (TGF-{beta}) SIGNALING PATHWAYS IN GLIOMA INITIATING CELLS (GICS)
Conclusions: We propose that a new combinatorial therapeutic to target both TGF-β and Notch might be more effective in cases of partial or no response to therapies based on either drug alone.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Torrejon Castro, D., Bonavia, R., Chiollaz, A., Seoane, J. Tags: CNS tumours Source Type: research

429p * phase ii trial of temozolomide and reirradiation using conformal 3d-radiotherapy in recurrent brain gliomas
Conclusions: Temozolomide and conformal radiotherapy had an anti-tumor activity in recurrent malignant glioma, and represented a good treatment hope for patients with recurrent brain glioma.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Osman, M. A. M., Mohamed, H. Tags: CNS tumours Source Type: research

431p * bevacizumab and fotemustine for recurrent high grade gliomas
Conclusions: In our study the combination of FTM and bevacizumab was well tolerated and PFS-6 and OS confirmed published literature. Further studies are needed to demonstrate the benefit of this combination in the treatment of recurrent HGG.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Sponghini, A. P., Platini, F., Rondonotti, D., Trevisan, E., Soffietti, R. Tags: CNS tumours Source Type: research

439p * comparison of ct and 18f-flt pet/ct imaging for target volume delineating in patients with glioma
Conclusions: The uptakes of 18F-FLT were positively correlated with grade of glioma and tumor cell proliferation index. To delineate target volume by 18F-FLT PET/CT imaging, the GTV and CTV are smaller than CT. It maybe improves the accuracy of GTV and CTV in patients with glioma and, meanwhile, provides potential benefits to normal brain tissue.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Hu, X., Wang, S., Ma, L., Yuan, S., Yu, J. Tags: CNS tumours Source Type: research

440TiP * THE HERBY STUDY: A PHASE 2 OPEN-LABEL, RANDOMIZED, MULTICENTER STUDY OF BEVACIZUMAB-BASED THERAPY IN PEDIATRIC PATIENTS WITH NEWLY DIAGNOSED HIGH-GRADE GLIOMA
Background: Despite recent therapeutic advances, outcomes in pediatric high-grade glioma (HGG) remain poor. A phase 1 study (Glade-Bender et al., J Clin Oncol. 2008) indicated that bevacizumab (BEV) is well tolerated in children with refractory solid tumors and yielded pharmacokinetic data that support further studies of BEV in childhood cancer.Trial design: A total of 120 eligible patients aged 3 to 18 years with newly diagnosed, localized supratentorial or infratentorial cerebellar or peduncular, histologically confirmed World Health Organization grade 3 or 4 HGG (central independent histologic confirmation) will be rand...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Grill, J., Hargrave, D., Varlet, P., Jaspan, T., Jones, C., Massimino, M., Canete, A., Azizi, A. A., Le Deley, M., Saran, F., Morgan, P., Zahlmann, G., Zheng, M., Fuerst-Recktenwald, S., Berger, C., Bouffet, E., Vassal, G. Tags: CNS tumours Source Type: research

472p * phase 1/2a study of glutathione pegylated liposomal doxorubicin (2b3-101) in patients with brain metastases (bm) from solid tumors or recurrent high grade gliomas (hgg)
Conclusions: 2B3-101 is safe and well tolerated and shows activity in advanced BCBM and HGG pts, diseases with limited treatment options. Results warrant further randomized, controlled Phase 2b studies, with initial focus on (HER2+) BCBM. ClinicalTrials.gov NCT01386580, sponsored by to-BBB technologies BV.Disclosure: B. Milojkovic Kerklaan: research grant; W. Gladdines: employee; F. Lonnqvist: employee. All other authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Brandsma, D., Kerklaan, B. M., Dieras, V., Altintas, S., Anders, C. K., Ballester, M. A., Gelderblom, H., Soetekouw, P. M. M. B., Gladdines, W., Lonnqvist, F., Jager, A., van Linde, M. E., Schellens, J., Aftimos, P. Tags: developmental therapeutics Source Type: research

1659p * inhibitors of proteolysis in cerebrospinal fluid of patients with malignant gliomas after two types of local intraoperative chemotherapy
Conclusions: Moderate activation of EI in treatment of MG and their stabilization stimulate endogenous protection in both types of therapy, but LICT-2 appeared to be more adequate.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Kozlova, L., Frantsiyants, E., Atmachidi, D., Gorbunova, T. Tags: tumour biology and pathology Source Type: research

Spatial and temporal evolution of distal 10q deletion, a prognostically unfavorable event in diffuse low-grade gliomas
Deletion of the distal 10q arm in diffuse low-grade glioma is identified as a prognostic event (Source: Genome Biology)
Source: Genome Biology - September 23, 2014 Category: Genetics & Stem Cells Authors: Hinke van ThuijlIlari ScheininDaoud SieAgusti AlentornHendrik van EssenMartijn CordesRuth FleischeuerAnja GijtenbeekGuus BeuteWimar van den BrinkGerrit MeijerMiek HavenithAhmed IdbaihKhê Hoang-XuanKarima MokhtariRoel VerhaakPaul van der ValkMark van de W Source Type: research

Radioprotection of targeted and bystander cells by methylproamine
This study tested methylproamine for the radioprotection of both directly targeted and bystander cells. Methods T98G glioma cells were treated with 15 μM methylproamine and exposed to 137Cs γ-ray/X-ray irradiation and He2+ microbeam irradiation. Radioprotection of directly targeted cells and bystander cells was measured by clonogenic survival or γH2AX assay. Results Radioprotection of directly targeted T98G cells by methylproamine was observed for 137Cs γ-rays and X-rays but not for He2+ charged particle irradiation. The effect of methylpr...
Source: Strahlentherapie und Onkologie - September 23, 2014 Category: Cancer & Oncology Source Type: research

Association between XRCC1 polymorphisms and glioma risk among Chinese population
This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk. Genotypes were assessed in 368 Chinese glioma patients and 346 healthy controls. XRCC1 Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487) and three additional polymorphisms were directly sequenced. The frequency of Arg280His A allele was significant lower in glioma group than in healthy controls [9.6 vs 16 %, OR = 0.60 (0.46–0.80), P < 0.001]; the frequencies of GA or AA genotypes were different in two groups (16.6 vs 22.8 %, 1.3 vs 4.7 %). The frequency of Arg399Gln A allele was significant higher in glio...
Source: Medical Oncology - September 23, 2014 Category: Cancer & Oncology Source Type: research

Antiangiogenic therapy for high-grade glioma.
CONCLUSIONS: In patients with newly diagnosed GBM, the use of antiangiogenic therapy does not improve survival, despite evidence of improved progression-free survival. Thus at this time, evidence is insufficient to support the use of antiangiogenic therapy in patients with newly diagnosed GBM on the basis of effects on survival.Bevacizumab may confer a progression-free survival benefit in GBM; however evidence in favour of using other antiangiogenic therapies in recurrent GBM is insufficient.Although bevacizumab appears to prolong progression-free survival in newly diagnosed and recurrent GBM, the impact of this on quality...
Source: Cochrane Database of Systematic Reviews - September 22, 2014 Category: Journals (General) Authors: Khasraw M, Ameratunga MS, Grant R, Wheeler H, Pavlakis N Tags: Cochrane Database Syst Rev Source Type: research

Epidemiology of meningiomas.
Abstract Although they represent about a third of all the tumors of the central nervous system, knowledge concerning meningioma epidemiology (including incidence data and exploration of the risk factors) remains scarce compared to that of gliomas. A limited number of cancer registries worldwide only record malignant brain tumors, however their completeness and accuracy have been questioned. Even if comparisons are made difficult due to differences in methodologies, available annual incidence rates (sex- and age-standardized, generally on US or World standard population), provided by population-based registries rang...
Source: Neuro-Chirurgie - September 20, 2014 Category: Neurosurgery Authors: Baldi I, Engelhardt J, Bonnet C, Bauchet L, Berteaud E, Grüber A, Loiseau H Tags: Neurochirurgie Source Type: research

Therapeutic Targeting of Malignant Glioma
(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))
Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) - September 19, 2014 Category: Cancer & Oncology Authors: Alexandru-Abrams, DanielaR. Jadus, MartinP. Hsu, FrankStathopoulos, ApostolosA. Bota, Daniela Tags: Articles Source Type: research

Translational Gap in Glioma Research
(Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents))
Source: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) - September 19, 2014 Category: Cancer & Oncology Authors: Ma, ChiZhao, GangHilda Cruz, MabelSiden, AkeSebastian Yakisich, Juan Tags: Articles Source Type: research

Cn‐AMP2 from green coconut water is an anionic anticancer peptide
Globally, death due to cancers is likely to rise to over 20 million by 2030, which has created an urgent need for novel approaches to anticancer therapies such as the development of host defence peptides. Cn‐AMP2 (TESYFVFSVGM), an anionic host defence peptide from green coconut water of the plant Cocos nucifera, showed anti‐proliferative activity against the 1321N1 and U87MG human glioma cell lines with IC50 values of 1.25 and 1.85 mM, respectively. The membrane interactive form of the peptide was found to be an extended conformation, which primarily included β‐type structures (levels > 45%) and random coil...
Source: Journal of Peptide Science - September 19, 2014 Category: Biochemistry Authors: Saurabh Prabhu, Sarah R. Dennison, Manuela Mura, Robert W. Lea, Timothy J. Snape, Frederick Harris Tags: Research Article Source Type: research

Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case-control study
Conclusions: Our findings demonstrate for the first time that a higher mtDNA content in PBLs is associated with an elevated risk of glioma, which warrants further investigation in larger populations. (Source: BMC Cancer)
Source: BMC Cancer - September 19, 2014 Category: Cancer & Oncology Authors: Jie ZhangDeyang LiFalin QuYibing ChenGang LiHequn JiangXiaojun HuangHushan YangJinliang Xing Source Type: research

Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas
Conclusions: ECT2 expression is positively correlated with WHO pathologic grading and unfavorable survival, suggesting that ECT2 may be a potential therapeutic candidate in human gliomas. (Source: Neurology India)
Source: Neurology India - September 19, 2014 Category: Neurology Authors: Yung-Sheng ChengChin LinYen-Po ChengYi-Lin YuChi-Tun TangDueng-Yuan Hueng Source Type: research

Bilateral thalamic gliomas: Report of two cases with review of literature
Bi-Wu Wu, Yi Zhang, Wen-Gang Li, Zhi-Qi LiNeurology India 2014 62(4):438-440 (Source: Neurology India)
Source: Neurology India - September 19, 2014 Category: Neurology Authors: Bi-Wu WuYi ZhangWen-Gang LiZhi-Qi Li Source Type: research

Peri-ictal pseudoprogression [pipg] in an operated case of right frontal glioma; case report and review of literature
Boby Varkey Maramattom, Dilip PanikarNeurology India 2014 62(4):461-463 (Source: Neurology India)
Source: Neurology India - September 19, 2014 Category: Neurology Authors: Boby Varkey MaramattomDilip Panikar Source Type: research

Isolated primary central nervous system lymphoma arising from the optic chiasm.
Abstract A 58-year-old previously healthy woman rapidly developed progressive bilateral visual loss. Magnetic resonance imaging revealed a bulging appearance of the optic chiasm, with homogeneous enhancement after gadolinium administration, which suggested an optic glioma or inflammatory disease. In the absence of (para)clinical clues for a specific diagnosis despite extensive investigation, a biopsy of one optic nerve was performed, resulting in a diagnosis of non-Hodgkin B-cell lymphoma. There was no evidence of any other ocular or systemic involvement, therefore the conclusion was that this immunocompetent patie...
Source: Neuro-Chirurgie - September 19, 2014 Category: Neurosurgery Authors: Vassal F, Pommier B, Boutet C, Forest F, Campolmi N, Nuti C Tags: Neurochirurgie Source Type: research

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma
Nature Reviews Cancer 14, 651 (2014). doi:10.1038/nrc3811 Authors: Chris Jones & Suzanne J. Baker Diffuse high-grade gliomas (HGGs) of childhood are a devastating spectrum of disease with no effective cures. The two-year survival for paediatric HGG ranges from 30%, for tumours arising in the cerebral cortex, to less than 10% for diffuse intrinsic pontine gliomas (DIPGs), which arise in (Source: Nature Reviews Cancer)
Source: Nature Reviews Cancer - September 18, 2014 Category: Cancer & Oncology Authors: Chris JonesSuzanne J. Baker Tags: Review Source Type: research

Hypothermia Stimulates Glioma Stem Spheres to Spontaneously Dedifferentiate Adjacent Non-stem Glioma Cells.
In this study, tracking the non-stem cells, we found that they could be attracted by stem spheres, and finally enter the stem spheres to become a member of stem spheres in vitro. However, these induced stem-like cells positive of CD133 and Nestin markers could not form an obvious sphere. To better understand the genetic differences of the stem spheres and stem-like cells underlying the change of microenvironment, we carried out Cytokine antibody array, Cancer PathwayFinder PCR array, and miRNA chip array, which demonstrated that lots of cytokines, mRNAs, and miRNAs involved in this microenvironmental change. In this study,...
Source: Cellular and Molecular Neurobiology - September 17, 2014 Category: Cytology Authors: Shi L, Fei X, Sun G, Wang Z, Wan Y, Zeng Y, Guo J Tags: Cell Mol Neurobiol Source Type: research

Identifying radiographic specificity for phosphatase and tensin homolog and epidermal growth factor receptor changes: a quantitative analysis of glioblastomas
Conclusions Based on voxel-based imaging analyses, our results suggest that genetic changes during the tumorigenic process may have anatomical specificity. We hope that this identified correlation between these biomarkers and the anatomical distribution of glioblastomas will help enhance our understanding of the molecular mechanisms underlying glioblastoma development and progression. (Source: Neuroradiology)
Source: Neuroradiology - September 17, 2014 Category: Radiology Source Type: research

Resting state fMRI feature-based cerebral glioma grading by support vector machine
Conclusion  Parameters of RS-fMRI are effective to classify the tumor grade in glioma cases. The results indicate that this technique has clinical potential to serve as a complementary diagnostic tool. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - September 17, 2014 Category: Intensive Care Source Type: research

Metabolic syndrome factors and risk of postoperative depression in high-grade glioma patients in a 1.5-year prospective study
Abstract To date, the relationship between metabolic syndrome factors and the risk of glioma-related depression is still unclear, and no study investigates this relationship. Our aim was to investigate the relationship between metabolic syndrome factors and the risk of postoperative depression in high-grade patients. A total of 386 high-grade glioma patients participated in blood sample collection for metabolic syndrome factors analysis and the hospital anxiety and depression scale testing. The association between metabolic syndrome factors and the risk of postoperative depression was assessed using Cox regressio...
Source: Medical Oncology - September 16, 2014 Category: Cancer & Oncology Source Type: research

Atypical hematologic and renal manifestations in Neurofibromatosis type I: Coincidence or pathophysiological link?
We report a family with NF1 in which two members presented atypical clinical features in addition to the classical diagnostic criteria. Three relatives affected by NF1, a father and two of his three sons, are described. The clinical diagnosis was originally worn in all three cases, with the association many spots café-au -lait over the entire body and some axillary freckling as well as first-degree relative. One case presented an Acute Myeloid Leukemia (AML) type 2 at 10 years of age diagnosed before the revelation of bicytopenia associated pallor and isolated asthenia. A second case presented a nephrotic syndrome at 4 ye...
Source: European Journal of Medical Genetics - September 16, 2014 Category: Genetics & Stem Cells Authors: Van-Gils J, Harambat J, Jubert C, Vidaud D, Llanas B, Perel Y, Lacombe D, Goizet C Tags: Eur J Med Genet Source Type: research