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Glioma

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Angiocentric glioma: a rare intractable epilepsy-related tumour in children.
We present two teenage cases of the angiocentric variant of glioma: 1) a 15-year-old girl with a chronic and intractable partial epilepsy with cystic tumour located in the right temporal lobe and 2) a 14-year-old boy with intractable seizures and an extensive cortical lesion in the left parieto-occipital area. In both cases, the total tumours excision was performed. The histopathological findings revealed a characteristic angiocentric pattern that was composed of elongated cells arranging in pseudorosette-like structures around blood vessels. Moreover, schwannoma-like areas and subpial neoplastic infiltration with palisadi...
Source: Folia Neuropathologica - October 17, 2014 Category: Pathology Authors: Grajkowska W, Matyja E, Daszkiewicz P, Roszkowski M, Peregud-Pogorzelski J, Jurkiewicz E Tags: Folia Neuropathol Source Type: research

Abnormalities in the normal appearing white matter of the cerebral hemisphere contralateral to a malignant brain tumor detected by diffusion tensor imaging.
CONCLUSIONS: In patients with previously untreated anaplastic astrocytoma or glioblastoma, an increase of the ADC and a reduction of FA were found in the brain parenchyma of the hemisphere contralateral to the tumor localization. In the absence of visible MRI abnormalities, this may be an early indicator of microstructural changes of the NAWM attributed to malignant brain tumor. PMID: 25310733 [PubMed - in process] (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - October 17, 2014 Category: Pathology Authors: Kallenberg K, Goldmann T, Menke J, Strik H, Bock HC, Mohr A, Buhk JH, Frahm J, Dechent P, Knauth M Tags: Folia Neuropathol Source Type: research

Anatomical localization of isocitrate dehydrogenase 1 mutation: a voxel‐based radiographic study of 146 low‐grade gliomas
ConclusionsLow‐grade gliomas with IDH1 mutation are region‐specific and preferentially located surrounding the rostral extension of the lateral ventricles. Furthermore, such mutations are associated with a favorable clinical outcome. (Source: European Journal of Neurology)
Source: European Journal of Neurology - October 16, 2014 Category: Neurology Authors: Y. Wang, T. Zhang, S. Li, X. Fan, J. Ma, L. Wang, T. Jiang Tags: Original Article Source Type: research

Drosophila oncogene Gas41 is RNAi modulator that intersects heterochromatin and siRNA pathway
Abstract Glioma amplified sequence41 (Gas41) is a highly conserved putative transcription factor that is frequently abundant in human gliomas. Gas41 shows oncogenic activity by promoting cell growth and viability. Here we show Gas41 is required for proper functioning of RNAi machinery in the nuclei, though three basic structural domains of RNAi components PAZ, PIWI and dsRNA binding are absent in the structural sequences. Variations of structural domains are highly conversed among prokaryotes and eukaryotes. Gas41 interacts with cytological RNase III enzyme Dicer1 both biochemically and genetically. However, Drosophila Gas...
Source: FEBS Journal - October 16, 2014 Category: Research Authors: Sumit G. Gandhi, Indira Bag, Saswati Sengupta, Manika Pal‐Bhadra, Utpal Bhadra Tags: Original Article Source Type: research

Attention dysfunction of postoperative patients with glioma
Conclusions: High-grade glioma patients suffer more severe attention impairment. In addition, the frontal and parietal lobe glioma patients suffer attention dysfunction in dissimilar manner. These findings will provide important guidance on the care of glioma patients after therapy. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - October 15, 2014 Category: Cancer & Oncology Authors: Dazhao FangJian JiangXiaoyang SunWeijie WangNan DongXianhua FuCong PangXingui ChenLianshu Ding Source Type: research

Alternative lengthening of telomeres is enriched in, and impacts survival of TP53 mutant pediatric malignant brain tumors
We examined the association of ALT with alterations in genes found to segregate with specific histological phenotypes and with clinical outcome. ALT was detected almost exclusively in malignant tumors (p = 0.001). ALT was highly enriched in primitive neuroectodermal tumors (12 %), choroid plexus carcinomas (23 %) and high-grade gliomas (22 %). Furthermore, in contrast to adult gliomas, pediatric low grade gliomas which progressed to high-grade tumors did not exhibit the ALT phenotype. Somatic but not germline TP53 mutations were highly associated with ALT (p = 1.01 × 10−8). Of the other alterations examined...
Source: Acta Neuropathologica - October 15, 2014 Category: Neurology Source Type: research

Dynamic 18F‐FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses
Abstract In suspected grade II gliomas, three distinct patterns of time‐activity‐curves (TAC) on O‐(2‐[18F]fluoroethyl)‐1‐tyrosine (18F‐FET) positron emission tomography (PET) have been delineated: (i) increasing TAC homogeneously throughout the tumor, and decreasing TAC, (ii) either homogeneously throughout the tumor or (iii) only focally within otherwise increasing TAC patterns. Increasing TAC was associated with low‐grade histology and decreasing TAC with high‐grade histology. This prospective study analyzed whether these patterns correlate with distinct biological tumor subtypes and differential outco...
Source: International Journal of Cancer - October 14, 2014 Category: Cancer & Oncology Authors: Niklas Thon, Mathias Kunz, Lena Lemke, Nathalie L Jansen, Sabina Eigenbrod, Simone Kreth, Jürgen Lutz, Rupert Egensperger, Armin Giese, Jochen Herms, Michael Weller, Hans Kretzschmar, Jörg‐Christian Tonn, Christian laFougère, Friedrich‐Wilhelm Kret Tags: Early Detection and Diagnosis Source Type: research

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
J-Y Delattre, K Mokhtari & M Sanson (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - October 14, 2014 Category: Cancer & Oncology Authors: M LabussièreA L Di StefanoV GleizeB BoisselierM GiryS MangesiusA BrunoR PaterraY MarieA RahimianG FinocchiaroR S HoulstonK Hoang-XuanA IdbaihJ-Y DelattreK MokhtariM Sanson Tags: gliomas TERT promoter mutation prognostic impact IDH mutation gliomas molecular classification Source Type: research

The analysis of deregulated expression and methylation of the PER2 genes in gliomas
Conclusions: Since, the circadian clock controls expression of cell-cycle related genes, we suggest that disturbances in PER2 gene expression may result in disruption of the control of the normal circadian clock, thus benefiting the survival of cancer cells and promoting carcinogenesis. Differential expression of circadian genes in non-cancerous and cancerous cells may provide a molecular basis for chronotherapy of glioma. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - October 14, 2014 Category: Cancer & Oncology Authors: Wang FanXiaowei ChenCaiyan LiYongluoLvan ChenPingfei LiuZhijun Chen Source Type: research

Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood¿brain barrier model system
Conclusion: hBMVEC influence the gene expression of neighboring C6 glioma sCp. This change in gene expression is mediated by the secretion of IL-1? and IL-6 from hBMVEC. Furthermore, the hBMVEC-induced increase in neighboring C6 glioma sCp gene expression leads to an increased rate of hBMVEC iron efflux. Taken together, our results indicate that hBMVEC-secreted cytokine activity increases the gene expression of neighboring C6 glioma sCp, which reciprocally acts on basolateral hBMVEC Fpn to enhance brain iron import. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 14, 2014 Category: Molecular Biology Authors: Ryan McCarthyDaniel Kosman Source Type: research

Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood¿brain barrier model system
Conclusion: hBMVEC influence the gene expression of neighboring C6 glioma sCp. This change in gene expression is mediated by the secretion of IL-1β and IL-6 from hBMVEC. Furthermore, the hBMVEC-induced increase in neighboring C6 glioma sCp gene expression leads to an increased rate of hBMVEC iron efflux. Taken together, our results indicate that hBMVEC-secreted cytokine activity increases the gene expression of neighboring C6 glioma sCp, which reciprocally acts on basolateral hBMVEC Fpn to enhance brain iron import. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 14, 2014 Category: Molecular Biology Authors: Ryan McCarthyDaniel Kosman Source Type: research

Expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas
Conclusions Our results suggest that high RINT1 expression may represent a risk factor for LGG-related seizures and may be associated with seizure outcomes. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - October 11, 2014 Category: Cancer & Oncology Source Type: research

C-Glycoside Mimetics Inhibit Glioma Stem Cell Proliferation, Migration, and Invasion
Journal of Medicinal ChemistryDOI: 10.1021/jm500522y (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - October 10, 2014 Category: Chemistry Authors: Ludovic Clarion, Carine Jacquard, Odile Sainte-Catherine, Marc Decoux, Séverine Loiseau, Marc Rolland, Marc Lecouvey, Jean-Philippe Hugnot, Jean-Noël Volle, David Virieux, Jean-Luc Pirat and Norbert Bakalara Source Type: research

Glucocorticoid Receptor β Acts as a Co-activator of T-Cell Factor 4 and Enhances Glioma Cell Proliferation
Abstract We previously reported that glucocorticoid receptor β (GRβ) regulates injury-mediated astrocyte activation and contributes to glioma pathogenesis via modulation of β-catenin/T-cell factor/lymphoid enhancer factor (TCF/LEF) transcriptional activity. The aim of this study was to characterize the mechanism behind cross-talk between GRβ and β-catenin/TCF in the progression of glioma. Here, we reported that GRβ knockdown reduced U118 and Shg44 glioma cell proliferation in vitro and in vivo. Mechanistically, we found that GRβ knockdown decreased TCF/LEF transcriptional activity without affecting β-caten...
Source: Molecular Neurobiology - October 10, 2014 Category: Neurology Source Type: research

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector
S Iwamoto & N Kasahara (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - October 10, 2014 Category: Cancer & Oncology Authors: M TakahashiG ValdesK HiraokaA InagakiS KamijimaE MicewiczH E GruberJ M RobbinsD J JollyW H McBrideK S IwamotoN Kasahara Source Type: research

Signal transducer and activator of transcription 5b drives malignant progression in a PDGFB‐dependent proneural glioma model by suppressing apoptosis
Abstract Signal transducer and activator of transcription 5b (STAT5b) is likely the relevant STAT5 isoform with respect to the process of malignant progression in gliomas. STAT5b is a latent cytoplasmic protein involved in cell signaling through the modulation of growth factors, apoptosis, and angiogenesis. Previous in vitro studies have shown increased STAT5b expression in glioblastomas relative to low‐grade tumors and normal brain. We recently demonstrated that phosphorylated STAT5b associates with delta epidermal growth factor receptor in the nucleus and subsequently binds the promoters of downstream effector molecule...
Source: International Journal of Cancer - October 10, 2014 Category: Cancer & Oncology Authors: Loyola V. Gressot, Tiffany A. Doucette, Yuhui Yang, Gregory N. Fuller, Amy B. Heimberger, Oliver Bögler, Arvind Rao, Khatri Latha, Ganesh Rao Tags: Carcinogenesis Source Type: research

Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway
The objective of this study was to evaluate whether DHA inhibits cell proliferation and invasion in glioma cells, and to elucidate the underlying mechanisms. The results demonstrate that DHA treatment significantly inhibited cell proliferation, migration and invasion, as determined using viability, transwell migration, and matrix penetration assays, respectively. Western blot analysis revealed that protein expression levels of a disintegrin and metalloproteinase 17 (ADAM17), and phosphorylated epidermal growth factor receptor and AKT (p-EGFR and p-AKT, respectively), were suppressed by DHA. EGFR and AKT phosphorylation was...
Source: Neurological Sciences - October 10, 2014 Category: Neurology Source Type: research

TGF-β-induced hCG-β regulates redox homeostasis in glioma cells.
Abstract Transforming growth factor (TGF-β) is associated with the progression of glioblastoma multiforme (GBM)-the most malignant of brain tumors. Since there is a structural homology between TGF-β and human chorionic gonadotropin (hCG) and as both TGF-β and hCG-β are known regulators of oxidative stress and survival responses in a variety of tumors, the role of TGF-β in the regulation of hCG-β and its consequences on redox modulation of glioblastoma cells was investigated. A heightened hCG-β level was observed in GBM tumors. TGF-β treatment increased hCG-β expression in glioma cell lines, and this height...
Source: Molecular and Cellular Biochemistry - October 10, 2014 Category: Biochemistry Authors: Ahmad F, Ghosh S, Sinha S, Joshi SD, Mehta VS, Sen E Tags: Mol Cell Biochem Source Type: research

Tetraarsenic oxide-induced inhibition of malignant glioma cell invasion in vitro via a decrease in matrix metalloproteinase secretion and protein kinase B phosphorylation.
Conclusions These results showed that TAO effectively inhibits proliferation of glioblastoma cell lines and also exerts an anti-invasive effect via decreased MMP-2 secretion, decreased MT1-MMP expression, and the inhibition of Akt phosphorylation under conditions devoid of cytotoxicity. Further investigations using an in vivo model are needed to evaluate the potential role of TAO as an anti-invasive agent. PMID: 25303017 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - October 10, 2014 Category: Neurosurgery Authors: Gwak HS, Park MJ, Park IC, Woo SH, Jin HO, Rhee CH, Jung HW Tags: J Neurosurg Source Type: research

Differentiation of primary central nervous system lymphoma from high‐grade glioma and brain metastases using susceptibility‐weighted imaging
ConclusionsSWI is useful in differentiating of PCNSLs from high‐grade gliomas and brain metastases. Quantitative analysis of intratumoral hemorrhage and vessels from SWI imaging adds specificity to noninvasive differentiation of PCNSLs from high‐grade gliomas and brain metastases, which may have considerable overlap in their conventional MR imaging appearance. (Source: Brain and Behavior)
Source: Brain and Behavior - October 10, 2014 Category: Neurology Authors: Yaling Ding, Zhen Xing, Biying Liu, Xinjian Lin, Dairong Cao Tags: Original Research Source Type: research

PDE5 inhibitors enhance Celecoxib killing in multiple tumor types
The present studies determined whether clinically relevant phosphodiesterase 5 (PDE5) inhibitors interacted with a clinically relevant NSAID, celecoxib, to kill tumor cells. Celecoxib and PDE5 inhibitors interacted in a greater than additive fashion to kill multiple tumor cell types. Celecoxib and sildenafil killed ex vivo primary human glioma cells as well as their associated activated microglia. Knock down of PDE5 recapitulated the effects of PDE5 inhibitor treatment; the nitric oxide synthase inhibitor L‐NAME suppressed drug combination toxicity. The effects of celecoxib were COX2 independent. Over‐expression of c...
Source: Journal of Cellular Physiology - October 9, 2014 Category: Cytology Authors: Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Seyedmehrad Tavallai, Timothy Webb, Peter Samuel, Adam Conley, Brittany Binion, Harold F. Young, Andrew Poklepovic, Sarah Spiegel, Paul Dent Tags: Original Research Article Source Type: research

Effect of PKCα expression on Bcl-2 phosphorylation and cell death by hypericin
Abstract In order to explain the contribution of the protein kinase Cα (PKCα) in apoptosis induced by photo-activation of hypericin (Hyp), a small interfering RNA was used for post-transcriptional silencing of pkcα gene expression. We have evaluated the influence of Hyp photo-activation on cell death in non-transfected and transfected (PKCα−) human glioma cells (U-87 MG). No significant differences were detected in cell survival between non-transfected and transfected PKCα− cells. However, the type of cell death was notably affected by silencing the pkcα gene. Photo-activation of Hyp strongly induced...
Source: Apoptosis - October 9, 2014 Category: Molecular Biology Source Type: research

Erratum to: Temozolomide after radiotherapy in recurrent ‘‘low grade’’ diffuse brainstem glioma in adults
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 9, 2014 Category: Cancer & Oncology Source Type: research

Investigation on the role of integrated PET/MRI for target volume definition and radiotherapy planning in patients with high grade glioma.
CONCLUSIONS: Our data suggest that the target volume definition using FLAIR-MRI is more adequate compared to enhanced T1MRI. 11C-METPET uptake could help identify microscopic residual areas. PMID: 25308182 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - October 9, 2014 Category: Radiology Authors: Navarria P, Reggiori G, Pessina F, Ascolese AM, Tomatis S, Mancosu P, Lobefalo F, Clerici E, Lopci E, Bizzi A, Grimaldi M, Chiti A, Simonelli M, Santoro A, Bello L, Scorsetti M Tags: Radiother Oncol Source Type: research

Brain-Penetrating Nanoparticles Improve Paclitaxel Efficacy in Malignant Glioma Following Local Administration
ACS NanoDOI: 10.1021/nn504210g (Source: ACS Nano)
Source: ACS Nano - October 8, 2014 Category: Nanotechnology Authors: Elizabeth Nance, Clark Zhang, Ting-Yu Shih, Qingguo Xu, Benjamin S. Schuster and Justin Hanes Source Type: research

Prediction of Glioma Recurrence Using Dynamic 18F-Fluoroethyltyrosine PET [BRAIN]
CONCLUSIONS: 18F-fluoroethyltyrosine-PET can predict recurrence in patients with glioma, with dynamic analysis showing advantages over static imaging, especially in the low-grade subgroup. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - October 8, 2014 Category: Radiology Authors: Pyka, T., Gempt, J., Ringel, F., Huttinger, S., van Marwick, S., Nekolla, S., Wester, H.- J., Schwaiger, M., Forster, S. Tags: BRAIN Source Type: research

RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas [RESEARCH]
Studies of gene rearrangements and the consequent oncogenic fusion proteins have laid the foundation for targeted cancer therapy. To identify oncogenic fusions associated with glioma progression, we catalogued fusion transcripts by RNA-seq of 272 gliomas. Fusion transcripts were more frequently found in high-grade gliomas, in the classical subtype of gliomas, and in gliomas treated with radiation/temozolomide. Sixty-seven in-frame fusion transcripts were identified, including three recurrent fusion transcripts: FGFR3-TACC3, RNF213-SLC26A11, and PTPRZ1-MET (ZM). Interestingly, the ZM fusion was found only in grade III astro...
Source: Genome Research - October 8, 2014 Category: Genetics & Stem Cells Authors: Bao, Z.-S., Chen, H.-M., Yang, M.-Y., Zhang, C.-B., Yu, K., Ye, W.-L., Hu, B.-Q., Yan, W., Zhang, W., Akers, J., Ramakrishnan, V., Li, J., Carter, B., Liu, Y.-W., Hu, H.-M., Wang, Z., Li, M.-Y., Yao, K., Qiu, X.-G., Kang, C.-S., You, Y.-P., Fan, X.-L., So Tags: RESEARCH Source Type: research

Erratum to: The survival of patients with high grade glioma from different ethnic groups in South East England
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 8, 2014 Category: Cancer & Oncology Source Type: research

Gliomas and BRCA genes mutations: fortuitous association or imputability?
We report the cases of two female patients aged 40 and 58-years-old female patients and one 35-years-old male patient, with brain or medullar gliomas, carriers of a germline mutation of BRCA gene. Those gliomas were particularly aggressive and were not responding to the standard treatment, with chemo and radiotherapy. The very unusual characteristics in location and evolutive profile of these central nervous system tumors raise the question of a genetical underlying mechanism, maybe linked to the BRCA gene mutation that carry these patients. In addition, a non-fortuitous association between germline mutation of BRCA and oc...
Source: Bulletin du Cancer - October 8, 2014 Category: Cancer & Oncology Authors: Girardstein-Boccara L, Mari V, Met-Domestici M, Burel-Vandenbos F, Berthet P, Paquis P, Frenay MP, Lebrun-Frenay C Tags: Bull Cancer Source Type: research

Potent tumor tropism of induced pluripotent stem cells and induced pluripotent stem cell-derived neural stem cells in the mouse intracerebral glioma model.
Abstract Although neural and mesenchymal stem cells have been well-known to have a strong glioma tropism, this activity in induced pluripotent stem cells (iPSCs) has not yet been fully studied. In the present study, we tested tumor tropic activity of mouse iPSCs and neural stem cells derived from the iPSC (iPS-NSCs) using in vitro Matrigel invasion chamber assay and in vivo mouse intracranial tumor model. Both iPSC and iPS-NSC had a similar potent in vitro tropism for glioma conditioned media. The migrated iPSCs to the gliomas kept expressing Nanog-GFP gene, suggesting no neuronal or glial differentiation. iPSCs...
Source: International Journal of Oncology - October 8, 2014 Category: Cancer & Oncology Authors: Yamazoe T, Koizumi S, Yamasaki T, Amano S, Tokuyama T, Namba H Tags: Int J Oncol Source Type: research

A Prospective Study of Height and Body Mass Index in Childhood, Birth Weight, and Risk of Adult Glioma Over 40 Years of Follow-up
Greater attained height and greater body mass index (BMI; weight (kg)/height (m)2) in young adulthood have been associated with glioma risk, but few studies have investigated the association with body size at birth or during childhood, when the brain undergoes rapid cell growth and differentiation. The Copenhagen School Health Records Register includes data on 320,425 Danish schoolchildren born between 1930 and 1989, with height and weight measurements from ages 7–13 years and parentally recorded birth weights. We prospectively evaluated associations between childhood height and BMI, birth weight, and adult glioma ri...
Source: American Journal of Epidemiology - October 7, 2014 Category: Epidemiology Authors: Kitahara, C. M., Gamborg, M., Rajaraman, P., Sorensen, T. I. A., Baker, J. L. Tags: RESEARCH-ARTICLE Source Type: research

Adult OPC gliomagenesis by multistep reactivation [Genetics]
How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs rarely proliferate compared with their perinatal counterparts. Whether these relatively... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 7, 2014 Category: Science Authors: Galvao, R. P., Kasina, A., McNeill, R. S., Harbin, J. E., Foreman, O., Verhaak, R. G. W., Nishiyama, A., Miller, C. R., Zong, H. Tags: PNAS Plus Source Type: research

DNA‐PKcs deficiency inhibits glioblastoma cell‐derived angiogenesis after ionizing radiation
DNA‐dependent protein kinase catalytic subunit (DNA‐PKcs) plays a critical role in non‐homologous end‐joining repair of DNA double‐strand breaks (DSB) induced by ionizing radiation (IR). Little is known, however, regarding the relationship between DNA‐PKcs and IR‐induced angiogenesis; thus, in this study we aimed to further elucidate this relationship. Our findings revealed that lack of DNA‐PKcs expression or activity sensitized glioma cells to radiation due to the defective DNA DSB repairs and inhibition of phosphorylated AktSer473. Moreover, DNA‐PKcs deficiency apparently mitigated IR‐induced migratio...
Source: Journal of Cellular Physiology - October 7, 2014 Category: Cytology Authors: Yang Liu, Luwei Zhang, Yuanyuan Liu, Chao sun, Hong Zhang, Guoying Miao, Cui Xiao Di, Xin Zhou, Rong Zhou, Zhenhua Wang Tags: Original Research Article Source Type: research

Improving the Quality of Care for Patients Diagnosed With Glioma During the Perioperative Period.
CONCLUSION: QI principles were used by a multidisciplinary team to improve the quality of care for patients with glioma during the perioperative period. Leadership involvement, ongoing dialogue across departments, and reporting of system performance were important for sustaining process improvements. PMID: 25294392 [PubMed - as supplied by publisher] (Source: JOP)
Source: JOP - October 7, 2014 Category: Gastroenterology Authors: Riblet NB, Schlosser EM, Homa K, Snide JA, Jarvis LA, Simmons NE, Sargent DH, Mason LP, Cooney TJ, Kennedy NL, Fadul CE Tags: J Oncol Pract Source Type: research

Perspectives for immunotherapy in glioblastoma treatment
Purpose of reviewAvoiding immune destruction is one emerging hallmark of cancer, including glioblastoma. The number of immunotherapy approaches to fight glioblastoma is growing. Here, we review the recent progress in four main areas: dendritic cell immunotherapy, peptide vaccination, chimeric antigen receptors and immune checkpoints. Recent findingsWe and others are using dendritic cells to present glioblastoma antigens (whole tumor lysate) to the immune system; our initial data indicate that clinical benefit is associated to increased presence of natural killer cells in the periphery. A pilot study loading dendritic cells...
Source: Current Opinion in Oncology - October 6, 2014 Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

Low-grade glioma management: a contemporary surgical approach
Purpose of reviewThe primary treatment of low-grade gliomas is still claimed to lack robust supporting evidence. Yet, several investigations were performed in the last 2 decades. To critically review these studies could help in further clarifying the role of surgery aimed at maximal resection. Recent findingsDespite the lack of randomized clinical trials hampering the performance of appropriate meta-analyses, the increasing amount of evidence pointed toward an aggressive surgical strategy to low-grade glioma. Low-grade glioma surgery has to be performed with the appropriate armamentarium, which is the availability of intra...
Source: Current Opinion in Oncology - October 6, 2014 Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

Heparan sulfate in regulation of neural differentiation and glioma development
This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - October 6, 2014 Category: Research Authors: Anqi Xiong, Soumi Kundu, Karin Forsberg‐Nilsson Tags: Review Article Source Type: research

Quantitative proteomic analysis of global effect of LLL12 on U87 cell's proteome: An insight into the molecular mechanism of LLL12.
This study investigated the global effect of LLL12 on the proteome of U87 glioma cells using complementary proteomic approaches, and our findings suggest that LLL12 influences central metabolism, translation, transport processes, and cytoskeleton of a cell in addition to its anti-angiogenic and apoptosis inducing functions which altogether contributes to anti-tumorigenic activity of LLL12. This study leads to the identification of several proteins which may serve as prognostic or predictive markers in GBM. We identified TPI1, PGAM1, CRK and BTF3 as potential therapeutic targets and further investigations on these candidate...
Source: Journal of Proteomics - October 5, 2014 Category: Biochemistry Authors: Jain R, Kulkarni P, Dhali S, Srikanth R, Srivastava S Tags: J Proteomics Source Type: research

A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT.
In this study, 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (BSBD) was shown to induce time- and dose-dependent apoptosis in SWO-38 human glioma cells by accumulation of a sub-G1 cell population, DNA fragmentation, nuclear condensation, caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage. Further mechanistic investigation showed that BSBD treatment induced dephosphorylation of AKT and DNA damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. Our findings suggest that BSBD represents a potential human glioma therapeutic. PMID: 25273058 [PubMed - ...
Source: Chemical and Pharmaceutical Bulletin - October 4, 2014 Category: Drugs & Pharmacology Authors: Zhang Y, Zheng S, Ngai SM, Zheng W, Li J, Chen T, Zhong X Tags: Chem Pharm Bull (Tokyo) Source Type: research

A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma
Conclusion: Glioma cell-specific bioluminescent assay is a reliable tool for assessment of cell viability in the brain tumor cell compartment following drug treatment. Moreover, we have applied this assay to demonstrate that astrocytes can modulate chemo sensitivity of GBM tumor cells. These effects varied both with the cell line and cytotoxic drug that were used, suggesting that several mechanisms may be involved. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - October 4, 2014 Category: Research Authors: Ning YangTao YanHuaiyang ZhuXiao LiangLina LeissPer SakariassenKai SkaftnesmoBin HuangDaniela CosteaPer EngerXingang LiJian Wang Source Type: research

Time to rethink the unthinkable: Upfront biopsy of children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)
(Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 4, 2014 Category: Cancer & Oncology Authors: Mark W. Kieran Tags: Highlight Source Type: research

Evaluation of Cytotoxic Properties of a Cyclopamine Glucuronide Prodrug in Rat Glioblastoma Cells and Tumors
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor. Activation of the developmental hedgehog (Hh) pathway is observed in GBM, particularly in the so-called glioma stem cells (GSCs). An inhibitor of this pathway is the steroidal alkaloid cyclopamine, an antagonist of the Hh coreceptor Smoothened (SMO). To limit the toxicity of cyclopamine toward Hh-dependent non-tumor cells, our group previously reported the synthesis of a prodrug (called 1b), designed to deliver cyclopamine in the presence of β-glucuronidase, an enzyme found in the necrotic area of GBM. Here, we aimed to ...
Source: Journal of Molecular Neuroscience - October 4, 2014 Category: Neuroscience Source Type: research

Expression of heat shock proteins in brain tumors.
CONCLUSION: Since HSPss are an attractive target for anticancer therapy, further studies are needed in order to better assess their relationship with tumor aggressiveness and patient prognosis. PMID: 25269047 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - October 3, 2014 Category: Neurosurgery Authors: Alexiou GA, Karamoutsios A, Lallas G, Ragos V, Goussia A, Kyritsis AP, Voulgaris S, Vartholomatos G Tags: Turk Neurosurg Source Type: research

Efficacy and safety of carmustine wafers in the treatment of glioblastoma multiforme: a systematic review.
Abstract The aim of this study was to a conduct a systematic review of carmustine wafers (Gliadel wafers) for the treatment of glioblastoma multiforme (GBM) to assess the survival benefit and safety of this therapy. The inclusion criteria were 1) prospective or retrospective clinical trial; 2) patients who had undergone resection for primary GBM or first recurrence of GBM with or without carmustine wafer implantation; 3) patients with malignant gliomas that included GBM; 4) outcomes including survival analysis of the GBM population. Six trials met the inclusion criteria; four were randomized, controlled trials and ...
Source: Turkish Neurosurgery - October 3, 2014 Category: Neurosurgery Authors: Zhang YD, Dai RY, Chen Z, Zhang YH, He XZ, Zhou J Tags: Turk Neurosurg Source Type: research

Incidence and dosimetric parameters of pediatric brainstem toxicity following proton therapy.
Conclusion. Utilization of current national brainstem dose guidelines is associated with a low risk of brainstem toxicity in pediatric patients. For young patients with posterior fossa tumors, particularly those who undergo aggressive surgery, our data suggest more conservative dosimetric guidelines should be considered. PMID: 25279957 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - October 3, 2014 Category: Cancer & Oncology Authors: Indelicato DJ, Flampouri S, Rotondo RL, Bradley JA, Morris CG, Aldana PR, Sandler E, Mendenhall NP Tags: Acta Oncol Source Type: research

Radiation-induced glioblastoma signaling cascade regulates viability, apoptosis and differentiation of neural stem cells (NSC)
In this study, we have evaluated the effects of irradiated glioblastoma cells on viability, proliferation and differentiation potential of non-irradiated (bystander) NSC through radiation-induced signaling cascades. Using media transfer experiments, we demonstrated significant effects of the U87MG glioblastoma secretome after gamma-irradiation on apoptosis in non-irradiated NSC. Addition of anti-TRAIL antibody to the transferred media partially suppressed apoptosis in NSC. Furthermore, we observed a dramatic increase in the production and secretion of IL8, TGFβ1 and IL6 by irradiated glioblastoma cells, which could promot...
Source: Apoptosis - October 1, 2014 Category: Molecular Biology Source Type: research

Isocitrate dehydrogenase-1 mutations as prognostic biomarker in glioblastoma multiforme patients in West Bohemia.
Abstract INTRODUCTION: Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. Recent whole-genome studies revealed novel GBM prognostic biomarkers such as mutations in metabolic enzyme IDH-isocitrate dehydrogenases (IDH1 and IDH2). The distinctive mutation IDH1 R132H was uncovered to be a strong prognostic biomarker for glioma patients. We investigated the prognostic role of IDH1 R132H mutation in GBM patients in West Bohemia. METHODS: The IDH1 R132H mutation was assessed by the RT-PCR in the tumor samples from 45 GBM patients treated in the Faculty Hospital in Pilsen and was correla...
Source: Biomed Res - October 1, 2014 Category: Research Authors: Polivka J, Polivka J, Rohan V, Pesta M, Repik T, Pitule P, Topolcan O Tags: Biomed Res Int Source Type: research

Superselective Intracerebral Catheterization for Administration of Oncolytic Virotherapy in a Case of Diffuse Intrinsic Pontine Glioma
We present here the initial experience of administering Celyvir, autologous mesenchymal stem cells infected with ICOVIR-5, an oncolytic adenovirus that selectively replicates in cancer cells, by means of superselective intra-arterial delivery, in a patient diagnosed of diffuse intrinsic pontine glioma. Feasibility, safety, and morbidity rates of the superselective catheterization technique are comparable with those of diagnostic angiography. The intra-arterial approach warrants a greater contact of the mesenchymal stem cells with the tumor mass, and minimizes hemorrhages or vascular disruption. The tolerance to the 2 admin...
Source: Journal of Pediatric Hematology Oncology - October 1, 2014 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Endoscopic supraorbital eyebrow approach for the surgical treatment of extraaxialand intraaxial tumors.
Conclusions The endoscopic supraorbital eyebrow approach is a safe and effective minimally invasive approach to remove extra- and intraaxial anterior skull base, parasellar, and frontal lesions, promoting a rapid recovery and short hospital stay. The location of the eyebrow incision demands a meticulous cosmetic closure, but, with proper technique, cosmetic results are excellent. PMID: 25270140 [PubMed - in process] (Source: Neurosurgical Focus)
Source: Neurosurgical Focus - October 1, 2014 Category: Neurosurgery Authors: Gazzeri R, Nishiyama Y, Ph D, Teo C Tags: Neurosurg Focus Source Type: research

Expanding indications for the extended endoscopic endonasal approach to hypothalamic gliomas: preliminary report.
Conclusions Despite the limitations of a short follow-up and small sample, the authors' early experience with the endoscopic endonasal approach has revealed it to be a direct, straightforward, and safe approach to third ventricle astrocytomas. It allowed the authors to perform tumor resection with the same microsurgical technique: dissecting the tumor with 2 hands, performing a central debulking, and controlling the bleeding with bipolar coagulation. The main limitations were represented by some anatomical conditions, such as the position of the chiasm and the anterior communicating artery complex and, finally, by the chal...
Source: Neurosurgical Focus - October 1, 2014 Category: Neurosurgery Authors: Zoli M, Mazzatenta D, Valluzzi A, Marucci G, Ph D, Acciarri N, Pasquini E, Frank G Tags: Neurosurg Focus Source Type: research