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Knockdown of PFTK1 Inhibits the Migration of Glioma Cells
In this study, we aimed to explore the expression and function in human glioma. Western blot and immunohistochemistry were used to evaluate the expression of PFTK1. PFTK1 expression was higher in glioma tissues compared with normal brain tissues, and its level was associated with the WHO grade in Western blot analysis. The suppression of PFTK1 expression by RNA interference was shown to inhibit the migration of glioma cells. Knockdown of PFTK1 increases E-cadherin expression and decreases vimentin expression. These data show that PFTK1 may participate in the pathogenic process of glioma, suggesting that PFTK1 can become a ...
Source: Journal of Molecular Neuroscience - August 4, 2015 Category: Neuroscience Source Type: research
Biomedical Imaging: Direct Solvent‐Derived Polymer‐Coated Nitrogen‐Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma (Small 29/2015)
Polymer‐coated, nitrogen‐doped, carbon nanodots (pN‐CNDs), shown as green/blue particles in the image, are produced by R. Q. Huang and co‐workers via a one‐step direct solvothermal reaction of 1‐methyl‐2‐pyrrolidinone. On page 3575, the pN‐CNDs are shown to expediently enter glioma via blood vessels and mediate glioma fluorescence imaging in vivo with good contrast, via enhanced passive targeting. (Source: Small)
Source: Small - August 3, 2015 Category: Nanotechnology Authors: Yi Wang, Ying Meng, Shanshan Wang, Chengyi Li, Wei Shi, Jian Chen, Jianxin Wang, Rongqin Huang Tags: Inside Front Cover Source Type: research
CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186.
In conclusion, CRNDE played an oncogenic role of GSCs through the negative regulation of miR-186. Both CRNDE and miR-186 could be regarded as potential targets in the glioma therapy. PMID: 26231038 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - August 2, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Schisandrin B suppresses glioma cell metastasis mediated by inhibition of mTOR/MMP-9 signal pathway
Conclusion Our findings demonstrate that Schisandrin B can suppress migration and invasion of glioma cell via PI3K/Akt-mTOR-MMP-9 signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - August 2, 2015 Category: Drugs & Pharmacology Source Type: research
Coexpression of cyclin D1 and alpha-internexin in oligodendroglial tumors
In this study, we investigated the expression status in 83 gliomas immunohistochemically, and found that cyclin D1-positive cells were commonly detected in gliomas. There was no correlation between the cyclin D1 and Ki-67 labeling indices, suggesting an unrecognized role of cyclin D1 other than a cell cycle regulator in gliomas. Cyclin D1/INA double-positive cells were consistently observed in oligodendroglial tumors regardless of histological grade. In 2 cases of oligodendroglioma with neuronal differentiation, the tumor cells of neuronal morphology showed higher expression of INA, suggesting INA expression may be associa...
Source: Brain Tumor Pathology - August 2, 2015 Category: Neurology Source Type: research
Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low‐grade glioma
ConclusionOur results demonstrate re‐exposure to be a safe alternative to abandoning carboplatin for patients with a hypersensitivity reaction. We propose a clinical algorithm for treatment. Pediatr Blood Cancer 2015; 9999:1–6 © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - August 1, 2015 Category: Cancer & Oncology Authors: Amish C. Shah, Jane E. Minturn, Yimei Li, Jean B. Belasco, Peter C. Phillips, Tammy I. Kang, Kristina A. Cole, Angela J. Waanders, Rosanna Pollack, Concetta Didomenico, Cynthia Wildes, Michael J. Fisher Tags: Research Article Source Type: research
Preparation, Characterization and Anti-Glioma Effects of Docetaxel-Incorporated Albumin-Lipid Nanoparticles
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - August 1, 2015 Category: Nanotechnology Authors: Gao, HuileCao, ShijieYang, ZhiZhang, ShuangZhang, QizhiJiang, Xinguo Tags: Articles Source Type: research
Vivo Diagnosis of Brain Glioma Using RGD-Decorated Fluorescent Carbonaceous Nanospheres
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - August 1, 2015 Category: Nanotechnology Authors: Ruan, ShaoboChen, JiantaoCun, XingliLong, YangTang, JieQian, JunShen, ShunJiang, XinguoZhu, JianhuaHe, QinGao, Huile Tags: Articles Source Type: research
Prognostic significance of multiple kallikreins in high-grade astrocytoma
In this study we determined KLK1, KLK6, KLK7, KLK8, KLK9 and KLK10 protein expression in two independent tissue microarrays containing 60 grade IV and 8 grade III astrocytoma samples. Scores for staining intensity, percent of tumor stained and immunoreactivity scores (IR, product of intensity and percent) were determined and analyzed for correlation with patient survival. Results: Grade IV glioma was associated with higher levels of kallikrein-immunostaining compared to grade III specimens. Univariable Cox proportional hazards regression analysis demonstrated that elevated KLK6- or KLK7-IR was associated with poor patient ...
Source: BMC Cancer - August 1, 2015 Category: Cancer & Oncology Authors: Kristen DruckerCaterina GianinniPaul DeckerEleftherios DiamandisIsobel Scarisbrick Source Type: research
High frequency of H3F3A K27M mutations characterizes pediatric and adult high-grade gliomas of the spinal cord
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - August 1, 2015 Category: Neurology Source Type: research
Paradoxical perfusion metrics of high-grade gliomas with an oligodendroglioma component: quantitative analysis of dynamic susceptibility contrast perfusion MR imaging
Conclusion In contrast to grade III tumors, the presence of oligodendroglial components in grade IV tumors resulted in paradoxically reduced perfusion metrics and MVD. In addition, patients with GBMO exhibited a better clinical outcome compared with patients with GBM. (Source: Neuroradiology)
Source: Neuroradiology - August 1, 2015 Category: Radiology Source Type: research
Single agent carboplatin for pediatric low‐grade glioma: A retrospective analysis shows equivalent efficacy to multi‐agent chemotherapy
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 1, 2015 Category: Cancer & Oncology Authors: Andrew J. Dodgshun, Wirginia J. Maixner, John A. Heath, Michael J. Sullivan, Jordan R. Hansford Tags: Cancer Therapy Source Type: research
Molecular biology techniques for loss of heterozygosity detection: the glioma example
ABSTRACT In recent years, many oncology institutions have implemented the use of molecular approaches to assess and manage cancer patients. One commonly observed type of genetic alteration in cancer is the loss of heterozygosity (LOH). In the clinical setting, this molecular genetic marker is an important tool for disease prognosis, diagnosis and treatment. For example, the loss of 1p/19q is a classical molecular marker for oligodendroglioma assessment. In addition, this marker is associated with a favorable prognosis and chemosensitivity in oligodendroglial tumors. Interpretation of the clinical significance of molecular ...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - July 31, 2015 Category: Pathology Source Type: research
Longitudinal Changes in Cerebellar and Thalamic Spontaneous Neuronal Activity After Wide-Awake Surgery of Brain Tumors: a Resting-State fMRI Study
Abstract Hypometabolism has been observed in the contralesional cerebellar hemisphere after various supratentorial cortical lesions. It is unknown whether the consequences of the dee- and deafferentation subsequent to wide-awake surgery for brain diffuse low-grade glioma can be assessed within remote and unresected subcortical structures such as the cerebellum or thalamus. To answer this question, we have conducted several regional analyses. More specifically, we have performed amplitude of low-frequency fluctuations (neuronal activity magnitude) and regional homogeneity (local temporal correlations) analyses on r...
Source: The Cerebellum - July 31, 2015 Category: Neurology Source Type: research
Prognostic role of IDH mutations in gliomas: a meta-analysis of 55 observational studies.
CONCLUSIONS: These findings provide further indication that patients with glioma harboring IDH mutations have improved OS and PFS, especially for patients with WHO grade III and grade II-III. PMID: 26220714 [PubMed - in process] (Source: Oncotarget)
Source: Oncotarget - July 31, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
An improved fluorescence polarization assay in 5'-nuclease reaction for gene promoter methylation detection
In this study, an improved gene promoter methylation assay based on fluorescence polarization in 5'-nuclease reaction was developed. The novel assay offered a homogeneous annealing and cleavage reaction fully integrated with PCR which used a probe labeled with fluorescence without quencher to obtain the decreased fluorescence polarization values. In this platform, gene promoter methylated and unmethylated alleles were detected simultaneously in a tube. O 6-methylguanine-DNA methyltransferase gene promoter methylation in 103 glioma tissue samples and epidermal growth factor receptor gene promoter methylation in 116 primary ...
Source: Journal of Biotechnology - July 31, 2015 Category: Biotechnology Source Type: research
Downregulation of serum microRNA-205 as a potential diagnostic and prognostic biomarker for human glioma.
CONCLUSIONS These data indicate that serum miR-205 expression is a novel and valuable biomarker for the diagnosis of glioma and a prognostic factor for those with a tumor at an advanced pathological grade. PMID: 26230475 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - July 31, 2015 Category: Neurosurgery Authors: Yue X, Lan F, Hu M, Pan Q, Wang Q, Wang J Tags: J Neurosurg Source Type: research
Secretory meningioma with KLF4 K409Q mutation in collision with glioma.
CONCLUSIONS: To our knowledge, these are the first two cases reported of the simultaneous occurrence of secretory meningiomas with mutation of KLF4 in collision with a glioblastoma and an anaplastic astrocytoma, respectively. These collision tumors presumably have different molecular origins. PMID: 26227255 [PubMed - as supplied by publisher] (Source: Clinical Neuropathology)
Source: Clinical Neuropathology - July 31, 2015 Category: Pathology Authors: Ruiz J, Capilla E, Díaz JF, Ruiz JA, Andrade J, Hernández T, Mollejo M, Meléndez B Tags: Clin Neuropathol Source Type: research
Neuroendoscopic Removal of Astrocytoma in Unilateral Ventricle in a Patient With Enlarged Perivascular Spaces: A Case Report and Review of the Literature
The authors report a case of astrocytoma, located in the right lateral ventricle in a 22-year-old man who presented with headache. Magnetic resonance imaging (MRI) also showed that the patient had multiple enlarged perivascular spaces. The patient underwent endoscopic removal through an aquiline incision placed 3 cm from the midline and 3 cm in front of the coronal suture. The histologic examination of tumor revealed a WHO I-II glioma. Despite the postoperative intraventricular hemorrhage and catheter infection, he was discharged home without neurologic deficits. The endoscopic fenestration rather than excision should be c...
Source: Neurosurgery Quarterly - July 30, 2015 Category: Neurosurgery Tags: Case Reports Source Type: research
Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-Conjugated Polylactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging.
In conclusion, IGPNE realizes real-time imaging of U87MG tumors and improves the antiangiogenic therapeutic efficacy in vivo. PMID: 26217880 [PubMed - as supplied by publisher] (Source: Molecular Imaging)
Source: Molecular Imaging - July 30, 2015 Category: Radiology Tags: Mol Imaging Source Type: research
Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma
In conclusion, modulation of PDGFR signaling by CD9 is evolutionarily conserved from Drosophila glia to human glioma and plays a role in glia migration. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - July 30, 2015 Category: Cancer & Oncology Source Type: research
Differential gene methylation in paired glioblastomas suggests a role of immune response pathways in tumor progression
Abstract DNA and histone methylation are post-transcriptional modifications that have been recently described in gliomas. Indeed, glioma CpG island hypermethylated phenotype has been identified as prognostic biomarker and as a surrogate marker of IDH1/2 mutations. However, the role of DNA methylation in glioblastoma progression is unknown. We sought to analyze DNA methylation levels in paired (initial and recurrent) primary glioblastoma samples to identify candidate pathways that may prone to glioblastoma progression. We have analyzed 12 samples (5 paired samples, two of them with three surgeries) using methylatio...
Source: Journal of Neuro-Oncology - July 30, 2015 Category: Cancer & Oncology Source Type: research
Secondary Data Analytics of Aquaporin Expression Levels in Glioblastoma Stem-Like Cells
Glioblastoma is the most common brain tumor in adults in which recurrence has been attributed to the presence of cancer stem cells in a hypoxic microenvironment. On the basis of tumor formation in vivo and growth type in vitro, two published microarray gene expression profiling studies grouped nine glioblastoma stem-like (GS) cell lines into one of two groups: full (GSf) or restricted (GSr) stem-like phenotypes. Aquaporin-1 (AQP1) and aquaporin-4 (AQP4) are water transport proteins that are highly expressed in primary glial-derived tumors. However, the expression levels of AQP1 and AQP4 have not been previously described i...
Source: Cancer Informatics - July 30, 2015 Category: Cancer & Oncology Authors: Raphael D. IsokpehiKatharina C. Wollenberg ValeroBarbara E. GrahamMaricica PacurariJennifer N. SimsUdensi K. UdensiKenneth Ndebele Source Type: research
The Dynamics of Interactions Among Immune and Glioblastoma Cells
Abstract Glioblastoma is the most common intracranial malignancy that constitutes about 50 % of all gliomas. Despite aggressive, multimodal therapy consisting of surgery, radiation, and chemotherapy, the outcome of patients with glioblastoma remains poor with 5-year survival rates of <10 %. Resistance to conventional therapies is most likely caused by several factors. Alterations in the functions of local immune mediators may represent a critical contributor to this resistance. The tumor microenvironment contains innate and adaptive immune cells in addition to the cancer cells and their surrounding stroma. Th...
Source: NeuroMolecular Medicine - July 30, 2015 Category: Neurology Source Type: research
Combined mutation and methylation status on long-term survival of patients with cerebral low-grade glioma
World Health Organization (WHO) grade II low-grade gliomas (LGGs), including diffuse astrocytoma (DA), oligodendroglioma (OG) and oligoastrocytoma (OA), have a relatively favorable but highly variable prognosis compared with high-grade gliomas (HGGs), known as WHO grade III anaplastic astrocytomas (AAs) and WHO grade IV glioblastomas (GBMs) [1,2]. Although some patients survive for decades, LGGs progress in an infiltrative manner and transform into malignant tumors with AA or secondary GBM. The management of LGG still remains controversial because surgical strategy and response to radiation therapy and chemotherapy are unc...
Source: Clinical Neurology and Neurosurgery - July 30, 2015 Category: Neurosurgery Authors: Kazuhiro Tanaka, Takashi Sasayama, Katsu Mizukawa, Kumi Takata, Nor Shazrina Sulaiman, Masamitsu Nishihara, Masaaki Kohta, Ryohei Sasaki, Takanori Hirose, Tomoo Itoh, Eiji Kohmura Source Type: research
Differentiation-inducing effects of betamethasone on human glioma cell line U251.
Abstract We studied the differentiation-inducing effect of beta-methasone on human glioma cell line U251 cultured in vitro, and the underlying mechanism. U251 cells were divided into two groups: con-trol group cells, cultured in Dulbecco's Modified Eagle's medium con-taining 10% fetal bovine serum; and medication group cells, treated with 15 μM betamethasone. Morphological cell changes were observed by inverted microscope, cell cycle changes were ascertained by flow cytometry, and vimentin expression was checked by immunocytochem-istry. The expression levels of extracellular signal-regulated protein ki-nase (ERK),...
Source: Genetics and Molecular Research - July 29, 2015 Category: Genetics & Stem Cells Authors: Jin T, Wang YX, Fan K, Tao DB, Dong X, Shen JS Tags: Genet Mol Res Source Type: research
Textural analysis of pre-therapeutic [18F]-FET-PET and its correlation with tumor grade and patient survival in high-grade gliomas
Conclusions Determination of uptake heterogeneity in pre-therapeutic FET-PET using textural features proved valuable for the (sub-)grading of high-grade glioma as well as prediction of tumor progression and patient survival, and showed improved performance compared to standard parameters such as TBR and tumor volume. Our results underscore the importance of intratumoral heterogeneity in the biology of high-grade glial cell tumors and may contribute to individual therapy planning in the future, although they must be confirmed in prospective studies before incorporation into clinical routine. (Source: European Jour...
Source: European Journal of Nuclear Medicine and Molecular Imaging - July 29, 2015 Category: Nuclear Medicine Source Type: research
Cancers, Vol. 7, Pages 1406-1424: Long Non-Coding RNAs: The Key Players in Glioma Pathogenesis
Long non-coding RNAs (LncRNAs) represent a novel class of RNAs with no functional protein-coding ability, yet it has become increasingly clear that interactions between lncRNAs with other molecules are responsible for important gene regulatory functions in various contexts. Given their relatively high expressions in the brain, lncRNAs are now thought to play important roles in normal brain development as well as diverse disease processes including gliomagenesis. Intriguingly, certain lncRNAs are closely associated with the initiation, differentiation, progression, recurrence and stem-like characteristics in glioma, and may...
Source: Cancers - July 29, 2015 Category: Cancer & Oncology Authors: Karrie KiangXiao-Qin ZhangGilberto Leung Tags: Review Source Type: research
The Use of Magnetic Resonance Imaging Screening for Optic Pathway Gliomas in Children with Neurofibromatosis Type 1
To evaluate the utility of screening brain/orbital magnetic resonance imaging (MRI) in a large population of children with neurofibromatosis type 1 (NF1) over a 20-year period. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - July 29, 2015 Category: Pediatrics Authors: Carlos E. Prada, Robert B. Hufnagel, Trent R. Hummel, Anne M. Lovell, Robert J. Hopkin, Howard M. Saal, Elizabeth K. Schorry Tags: Original Article Source Type: research
IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas.
CONCLUSIONS: For WHO grade II diffuse glioma, molecular classification using 1p/19qcodel, IDHmut, and ATRX loss more accurately predicts outcome and should be incorporated in the neuropathologic evaluation. PMID: 26210286 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - July 28, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature
Abstract Glioblastoma (GBM) are high-grade gliomas that severely impact on overall survival (OS). GBM cell motility and the breakdown of the blood–brain barrier could favor GBM cell communication with the systemic circulation. In spite of this, extracranial GBM metastases are rare. Here, we describe two YKL-40-positive GBM patients with extra-CNS (central nervous system) metastases, and we present a meta-analysis of 94 cases. The analysis concluded that extra-CNS metastases occurred 8.5 months after first GBM diagnosis and OS was 12 months; surgical GBM excision was associated at a longer interval to extra-CNS...
Source: Neurosurgical Review - July 28, 2015 Category: Neurosurgery Source Type: research
Relationship between inflammatory cytokines and risk of depression, and effect of depression on the prognosis of high grade glioma patients
Abstract Depression is found to be associated with up-regulation of inflammatory cytokines. However, the relationship in high grade glioma (HGG) patients is still unclear. In this prospective study, a total 132 HGG patients participated in blood sample collection for inflammatory cytokines detection by ELISA, mental status, quality of life (QOL) and physical functional status testing. The association between inflammatory cytokines and depression risk was assessed using conditional logistic regression. The incidences of depressive symptoms and depression in high grade glioama patients were 45.5 and 25 % respective...
Source: Journal of Neuro-Oncology - July 28, 2015 Category: Cancer & Oncology Source Type: research
Necessity for Intra-operative Magnetic Resonance Imaging for Glioma Resection
Publication date: Available online 15 July 2015 Source:World Neurosurgery Author(s): Richard M. Young, Jonathan H. Sherman (Source: World Neurosurgery)
Source: World Neurosurgery - July 28, 2015 Category: Neurosurgery Source Type: research
Longitudinal Change of Circumpapillary Retinal Nerve Fiber Layer Thickness in Children with Optic Pathway Gliomas
To evaluate longitudinal changes in circumpapillary retinal nerve fiber layer (RNFL) thickness, as measured by spectral-domain optical coherence tomography (SD-OCT), in children with optic pathway gliomas. (Source: American Journal of Ophthalmology)
Source: American Journal of Ophthalmology - July 28, 2015 Category: Opthalmology Authors: Robert A. Avery, Avital Cnaan, Joel S. Schuman, Carmelina Trimboli-Heidler, Chieh-Li Chen, Roger J. Packer, Hiroshi Ishikawa Tags: Original Articles Source Type: research
Neuroendocrine morbidity after pediatric optic gliomas: a longitudinal analysis of 166 children over 30 years.
CONCLUSIONS: This first longitudinal OP/HSG-specific study demonstrates that hypothalamo-pituitary dysfunction evolves hierarchically over decades. Tumor location predicts its speed of onset and radiotherapy its density. GnD can evolve from previous CPP, whilst life-threatening PPD can occur after any surgery. Our data suggest that recent radiation-avoiding chemotherapeutic strategies have increased GHD without improving survival. PMID: 26218754 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - July 28, 2015 Category: Endocrinology Authors: Gan HW, Phipps K, Aquilina K, Gaze MN, Hayward R, Spoudeas HA Tags: J Clin Endocrinol Metab Source Type: research
Definition of a serum marker panel for glioblastoma discrimination and identification of Interleukin 1β in the microglial secretome as a novel mediator of endothelial cell survival induced by C-Reactive Protein.
This study, besides defining a serum panel for glioblastoma discrimination, identified IL1β as a potential candidate for developing targeted therapy. PMID: 26232108 [PubMed - as supplied by publisher] (Source: Journal of Proteomics)
Source: Journal of Proteomics - July 28, 2015 Category: Biochemistry Authors: Nijaguna MB, Schröder C, Patil V, Sd S, Hegde AS, Chandramouli BA, Arivazhagan A, Santosh V, Hoheisel JD, Somasundaram K Tags: J Proteomics Source Type: research
The cap-translation inhibitor 4EGI-1 induces mitochondrial dysfunction via regulation of mitochondrial dynamic proteins in human glioma U251 cells
Publication date: Available online 26 July 2015 Source:Neurochemistry International Author(s): Xin Yang, Qiu-Feng Dong, Li-Wen Li, Jun-Li Huo, Peng-Qi Li, Zhou Fei, Hai-Ning Zhen Translation initiation factors (eIFs) are over-activated in many human cancers and may contribute to their progression. The small molecule 4EGI-1, a potent inhibitor of translation initiation through disrupting eIF4E/eIF4G interaction, has been shown to exert anti-cancer effects in human cancer cells. The goal of the present study was to evaluate the anti-cancer effects of 4EGI-1 in human glioma U251 cells. We found that 4EGI-1 impaired t...
Source: Neurochemistry International - July 27, 2015 Category: Neuroscience Source Type: research
CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility
The role of genetic polymorphisms in pediatric brain tumor (PBT) etiology is poorly understood. We hypothesized that single nucleotide polymorphisms (SNPs) identified in genome-wide association studies (GWAS) on adult glioma would also be associated with PBT risk. The study is based on the Cefalo study, a population-based multicenter case–control study. Saliva DNA from 245 cases and 489 controls, aged 7–19 years at diagnosis/reference date, was extracted and genotyped for 29 SNPs reported by GWAS to be significantly associated with risk of adult glioma. Data were analyzed using unconditional logistic regression...
Source: Carcinogenesis - July 27, 2015 Category: Cancer & Oncology Authors: Adel Fahmideh, M., Lavebratt, C., Schuz, J., Roosli, M., Tynes, T., Grotzer, M. A., Johansen, C., Kuehni, C. E., Lannering, B., Prochazka, M., Schmidt, L. S., Feychting, M. Tags: Original Manuscript Source Type: research
Diagnostic yield of targeted next generation sequencing in various cancer types: An information-theoretic approach
Publication date: Available online 29 May 2015 Source:Cancer Genetics Author(s): Ian S. Hagemann, Patrick K O'Neill, Ivan Erill, John D. Pfeifer The information-theoretic concept of Shannon entropy can be used to quantify the information provided by a diagnostic test. We hypothesized that in tumor types with stereotyped mutational profiles, the results of NGS testing would yield lower average information than in tumors with more diverse mutations. To test this hypothesis, we estimated the entropy of NGS testing in various cancer types, using results obtained from clinical sequencing. A set of 238 tumors were subjecte...
Source: Cancer Genetics - July 27, 2015 Category: Cancer & Oncology Source Type: research
The Value of Pre- and Intraoperative Adjuncts on the Extent of Resection of Hemispheric Low-Grade Gliomas: A Retrospective Analysis
Conclusions Using DES in combination with fMRI and DTI significantly improves EOR when LGGs are located in eloquent areas compared with craniotomies in which only NN was used.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - July 27, 2015 Category: Neurosurgery Authors: Incekara, FatihOlubiyi, OlutayoOzdemir, AysegulLee, TomRigolo, LauraGolby, Alexandra Tags: Original Article Source Type: research
Radiosurgery reirradiation for high-grade glioma recurrence: a retrospective analysis
Abstract Despite various treatment strategies being available, recurrent high-grade gliomas (r-HGG) are difficult to manage. To obtain local control, radiosurgery (SRS) reirradiation has been considered as potential treatment. In the present study, a retrospective analysis was performed on r-HGG patients treated with salvage single- (s-SRS) or multi-fraction SRS (m-SRS). The aim of this study was to evaluate the effectiveness of salvage SRS in terms of overall survival (OS); toxicity was analyzed as well. Between 2004 May and 2011 December, 128 r-HGG patients (161 lesions) treated with CyberKnife® SRS reirradiat...
Source: Neurological Sciences - July 26, 2015 Category: Neurology Source Type: research
Carboplatin hypersensitivity reactions in pediatric low grade glioma are protocol specific and desensitization shows poor efficacy
ConclusionsHypersensitivity reactions to carboplatin are more common in this cohort than previously reported and rates are protocol‐dependent. Desensitization showed limited effectiveness in this cohort. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - July 26, 2015 Category: Cancer & Oncology Authors: Andrew J. Dodgshun, Jordan R. Hansford, Theresa Cole, Sharon Choo, Michael J. Sullivan Tags: Research Article Source Type: research
Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response.
CONCLUSIONS: Our findings support studies indicating that tumor-derived endothelial cells arise in gliomas and describe a dynamic 3D culture as a bona fide model to interrogate the molecular basis of this phenomenon in vitro. Resistance to current anti-angiogenic therapies and the contribution of tumor derived endothelial cells to such resistance are amenable to study using the RCCS. PMID: 26203665 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - July 26, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Tumor infiltrating immune cells in gliomas and meningiomas
Publication date: Available online 26 July 2015 Source:Brain, Behavior, and Immunity Author(s): Patrícia Domingues, María González-Tablas, Álvaro Otero, Daniel Pascual, David Miranda, Laura Ruiz, Pablo Sousa, Juana Ciudad, Jesús María Gonçalves, María Celeste Lopes, Alberto Orfao, María Dolores Tabernero Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, wit...
Source: Brain, Behavior, and Immunity - July 26, 2015 Category: Neurology Source Type: research
E-011 the key role of the blood-brain barrier in the endovascular treatment of brain tumors and how to by-pass it: new methods
ConclusionIA chemotherapy has been reported to be a promising new therapy; clinical studies are necessary to correlate this technique to the new ways of altering the BBB. Furthermore, these new methods could also be used in future scenarios before infusion of stem cells after stroke or brain trauma.DisclosuresS. Peschillo: 2; C; Penumbra. F. Diana: None. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Peschillo, S., Diana, F. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research
Corrections to “Unsupervised Nosologic Imaging for Glioma Diagnosis” [Jun 13 1760-1763]
In the above-named work [ibid., vol. 60, no. 6, pp. 1760???1763, Jun. 2013], the first author's affiliation should have read: Y. Li is with the School of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu 611731 China, and also with the Department of Electrical Engineering and IBBT-Future Health Department, Katholieke Universiteit Leuven, Leuven 3001, Belgium (e-mail: yuqianli@ uestc.edu.cn). The sixth author Y. Pi's affiliation should have read: Y. Pi is with the School of Electronic Engineering, University of Electronic Science and Technology of China. (Source: IEEE Transactions on ...
Source: IEEE Transactions on Biomedical Engineering - July 25, 2015 Category: Biomedical Engineering Source Type: research
Outcomes in Reoperated Low-Grade Gliomas
BACKGROUND: Low-grade gliomas (LGGs) comprise a diverse set of intrinsic brain tumors that correlate strongly with survival. Data on the effect of reoperation are sparse. OBJECTIVE: To evaluate the effect of reoperation on patients with LGG. METHODS: Fifty-two consecutive patients with reoperated LGGs treated at the University of Washington between 1986 and 2004 were identified and evaluated in a retrospective analysis. RESULTS: The average overall survival (OS) for this cohort was 12.95 ± 0.96 years. The overall 10-year survival rate was 57%. The absence of any residual tumor at either the first or second operation was a...
Source: Neurosurgery - July 25, 2015 Category: Neurosurgery Tags: Research-Human-Clinical Studies Source Type: research
Dual Intraoperative Visualization Approach Surgery: A Novel Technique Enhances Intraoperative Glioma Visualization
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - July 25, 2015 Category: Neurosurgery Tags: Science Times Source Type: research
Insights into the clinical value of cyclin-dependent kinase 5 in glioma: a retrospective study
In this study, we aimed to evaluate the clinical value of CDK5 in different grades of glioma in relation to Ki-67 labeling index (LI). Methods: We firstly assessed by immunohistochemistry the expression of CDK5 in 152 glioma tissues and 16 normal brain tissues and further explored the relationship between CDK5 expression and other clinical features. Results: The positive ratio of CDK5 in gliomas (57.2 %) was higher than that in normal brain tissues (12.5 %, P = 0.001). Difference of CDK5 expression among four World Health Organization (WHO) grades was statistically significant (P = 0.001). The significant differe...
Source: World Journal of Surgical Oncology - July 25, 2015 Category: Cancer & Oncology Authors: Ruan YushanChen WenjieHuang SuningDang YiwuZhong TengfeiWickramaarachchi MadushiLuo FeifeiZhang ChangwenWen XinGopaul RoodrajeetsingLi ZuyunChen Gang Source Type: research
Tumor infiltrating immune cells in gliomas and meningiomas.
Abstract Tumor-infiltrating immune cells are part of a complex microenvironment that promotes and/or regulates tumor development and growth. Depending on the type of cells and their functional interactions, immune cells may play a key role in suppressing the tumor or in providing support for tumor growth, with relevant effects on patient behavior. In recent years, important advances have been achieved in the characterization of immune cell infiltrates in central nervous system (CNS) tumors, but their role in tumorigenesis and patient behavior still remain poorly understood. Overall, these studies have shown signifi...
Source: Brain, Behavior, and Immunity - July 25, 2015 Category: Neurology Authors: Domingues P, González-Tablas M, Otero Á, Pascual D, Miranda D, Ruiz L, Sousa P, Ciudad J, Gonçalves JM, Lopes MC, Orfao A, Tabernero MD Tags: Brain Behav Immun Source Type: research