Medicine RSS Search Engine

Glioma Glioma RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog.subscribe with FeedlySubscribe to this data using Feedly.

This page shows you the latest news and research items in this category.

Radiation therapy and concurrent topotecan followed by maintenance triple anti‐angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma
ConclusionsThe Angiocomb protocol created a noticeable share of long‐term survivors and was well tolerated, suggesting that anti‐angiogenic therapy for patients with DIPG should be studied more in the future. Pediatr Blood Cancer © 2014 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - April 1, 2014 Category: Cancer & Oncology Authors: Mikaela Porkholm, Leena Valanne, Tuula Lönnqvist, Stefan Holm, Birgitta Lannering, Pekka Riikonen, Dorota Wojcik, Astrid Sehested, Niels Clausen, Arja Harila‐Saari, Eckhard Schomerus, Halldora K. Thorarinsdottir, Päivi Lähteenmäki, Mikko Arola, Hara Tags: Research Article Source Type: research

How to treat tumefactive demyelinating disease?
Glioma-like inflammatory demyelinating lesions can be found in patients with pre-diagnosed multiple sclerosis, but they have also been described as an isolated disease entity. The initial diagnostic work-up usually includes a biopsy for histopathological analysis. However, even after unambiguous histopathologic classification, tumefactive lesions pose a therapeutic challenge. Until now, there have been no guidelines on how to treat patients with these rare and extreme lesion phenotypes. Here we report a patient with a relapsing unifocal tumefactive demyelinating lesion. The patient initially showed a good response to stero...
Source: Multiple Sclerosis - April 1, 2014 Category: Neurology Authors: Siffrin, V., Muller-Forell, W., von Pein, H., Zipp, F. Tags: Case Study Source Type: research

Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma
Tumour-infiltrating CD4+ and CD8+ lymphocytes as predictors of clinical outcome in glioma British Journal of Cancer advance online publication, April 1 2014. doi:10.1038/bjc.2014.162 Authors: S Han, C Zhang, Q Li, J Dong, Y Liu, Y Huang, T Jiang & A Wu (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - April 1, 2014 Category: Cancer & Oncology Authors: S HanC ZhangQ LiJ DongY LiuY HuangT JiangA Wu Source Type: research

Cytologic features of the normal pineal gland on squash preparations
We describe cytologic features of the normal pineal gland in patients of varying ages and identify common diagnostic pitfalls. We performed a retrospective review of pineal gland biopsies performed at our institution, where approximately 30,000 surgical specimens are accessioned yearly, for the last 23 years. Only two pineal gland biopsies were found. Although both cases were initially diagnosed as low‐grade gliomas on frozen section, the final diagnosis was benign pineal tissue based on light microscopy and immunohistochemistry results. Additionally, we performed squash preparations of five normal pineal gland autopsy s...
Source: Diagnostic Cytopathology - April 1, 2014 Category: Pathology Authors: Diana Murro, Alaa Alsadi, Sukriti Nag, Leonidas Arvanitis, Paolo Gattuso Tags: Original Article Source Type: research

Quantitative evaluation of boron neutron capture therapy (BNCT) drugs for boron delivery and retention at subcellular‐scale resolution in human glioblastoma cells with imaging secondary ion mass spectrometry (SIMS)
In this study, a secondary ion mass spectrometry based imaging instrument, a CAMECA IMS 3f ion microscope, capable of 500 nm spatial resolution was employed. Cryogenically prepared cultured human T98G glioblastoma cells were evaluated for boron uptake and retention of two delivery agents. The first, L‐p‐boronophenylalanine (BPA), has been used clinically for BNCT of high‐grade gliomas, recurrent tumours of the head and neck region and melanomas. The second, a boron analogue of an unnatural amino acid, 1‐amino‐3‐borono‐cyclopentanecarboxylic acid (cis‐ABCPC), has been studied in rodent glioma and melanoma mo...
Source: Journal of Microscopy - March 31, 2014 Category: Laboratory Medicine Authors: S. CHANDRA, T. AHMAD, R. F. BARTH, G. W. KABALKA Tags: Original Article Source Type: research

Near-Complete Resection of Brain Tumors Using Tumor PaintNear-Complete Resection of Brain Tumors Using Tumor Paint
The authors describe a proof-of-concept intraoperative near-infrared imaging system to detect a novel tumor ligand with a high affinity for glioma, potentially enabling near-complete tumor removal. Neurosurgical Focus (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 31, 2014 Category: Neurology Tags: Neurology & Neurosurgery Journal Article Source Type: news

Quantification of Antibody Delivery to Brain Tumor
High-grade gliomas often possess an impaired blood–brain barrier (BBB), which allows delivery of large molecules to brain tumors. However, achieving optimal drug concentrations in brain tumors remains a significant hurdle for treating patients successfully. Thus, detailed investigations of drug activities in gliomas are needed. To investigate BBB penetration, pharmacodynamics, and tumor retention kinetics of an agonistic DR5 antibody in a brain tumor xenograft model, we utilized a noninvasive imaging method for longitudinal monitoring of apoptosis induction. Brain tumors were induced by intracranial (i.c.) implantation o...
Source: Cancer Research - March 31, 2014 Category: Cancer & Oncology Authors: Weber, T. G., Osl, F., Renner, A., Poschinger, T., Galban, S., Rehemtulla, A., Scheuer, W. Tags: Integrated Systems and Technologies Source Type: research

Liver toxicity during temozolomide chemotherapy caused by Chinese herbs
Conclusions: We conclude that the observed toxicity with jaundice was probably caused by an interaction of this popular Chinese formula and temozolomide. This is the first report about a relevant interaction of temozolomide and any herbal formula. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - March 30, 2014 Category: Complementary Medicine Authors: Thomas MelchardtTeresa MagnesLukas WeissMichael GrundbichlerMichael StrasserClemens HufnaglMartin MoikRichard GreilAlexander Egle Source Type: research

Molecular imaging of angiogenesis to delineate the tumor margins in glioma rat model with endoglin‐targeted paramagnetic liposomes using 3T MRI
ConclusionThe two‐step endoglin‐targeted imaging using biotin‐streptavidin interaction was demonstrated to induce intense enhancement of the tumor periphery, which implies that this advanced MR molecular contrast agent may be suitable for accurately delineating glioma tumor margins.J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - March 27, 2014 Category: Radiology Authors: Long‐Hua Qiu, Jia‐Wen Zhang, Shu‐Ping Li, Cao Xie, Zhen‐Wei Yao, Xiao‐Yuan Feng Tags: Original Research Source Type: research

Ring cell migration assay identifies distinct effects of extracellular matrix proteins on cancer cell migration
Conclusions: Taken together, the ring cell migration assay is an easy, convenient and cost-effective assay to study cell migration in vitro. (Source: BioMed Central)
Source: BioMed Central - March 27, 2014 Category: Journals (General) Authors: Hui ChenJosephine Nalbantoglu Source Type: research

EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy.
Abstract Glioblastoma is a particularly resilient cancer, and while therapies may be able to reach the brain by crossing the blood-brain barrier, they then have to deal with a highly invasive tumor that is very resistant to DNA damage. It seems clear that in order to kill aggressive glioma cells more efficiently and with fewer side effects on normal tissue, there must be a shift from classical cytotoxic chemotherapy to more targeted therapies. Since the epidermal growth factor receptor (EGFR) is altered in almost 50 % of glioblastomas, it currently represents one of the most promising therapeutic targets. In fact,...
Source: Cellular and Molecular Life Sciences : CMLS - March 27, 2014 Category: Cytology Authors: Zahonero C, Sánchez-Gómez P Tags: Cell Mol Life Sci Source Type: research

Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals
Glioblastomas frequently harbour genetic lesions that stimulate the activity of mammalian target of rapamycin complex 1 (mTORC1). Loss of heterozygosity of tuberous sclerosis complex 1 (TSC1) or TSC2, which together form a critical negative regulator of mTORC1, is also seen in glioblastoma; however, it is not known how loss of the TSC complex affects the development of malignant gliomas. Here we investigated the role of Tsc1 in gliomagenesis in mice. Tsc1 deficiency up-regulated mTORC1 activity and suppressed the proliferation of neural stem/progenitor cells (NSPCs) in a serial neurosphere-forming assay, suggesting that Ts...
Source: Journal of Biochemistry - March 26, 2014 Category: Biochemistry Authors: Yamada, D., Hoshii, T., Tanaka, S., Hegazy, A. M., Kobayashi, M., Tadokoro, Y., Ohta, K., Ueno, M., Ali, M. A. E., Hirao, A. Tags: Regular Papers Source Type: research

Atopic conditions and brain tumor risk in children and adolescents--an international case-control study (CEFALO)
Conclusions There was no association between atopic conditions and risk of all brain tumors combined or of glioma in particular. Stratification on current or past atopic conditions suggested the possibility of reverse causality, but may also the result of random variation because of small numbers in subgroups. In addition, an ongoing tumor treatment may affect the manifestation of atopic conditions, which could possibly affect recall when reporting about a history of atopic diseases. Only a few studies on atopic conditions and pediatric brain tumors are currently available, and the evidence is conflicting. (Source: Annals of Oncology)
Source: Annals of Oncology - March 25, 2014 Category: Cancer & Oncology Authors: Shu, X., Prochazka, M., Lannering, B., Schuz, J., Roosli, M., Tynes, T., Kuehni, C. E., Andersen, T. V., Infanger, D., Schmidt, L. S., Poulsen, A. H., Klaeboe, L., Eggen, T., Feychting, M. Tags: epidemiology Source Type: research

Detecting treatment effects in GBM by APT imaging [Medical Sciences]
Glioblastoma multiforme (GBM), which account for more than 50% of all gliomas, is among the deadliest of all human cancers. Given the dismal prognosis of GBM, it would be advantageous to identify early biomarkers of a response to therapy to avoid continuing ineffective treatments and to initiate other therapeutic strategies.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - March 25, 2014 Category: Science Authors: Sagiyama, K., Mashimo, T., Togao, O., Vemireddy, V., Hatanpaa, K. J., Maher, E. A., Mickey, B. E., Pan, E., Sherry, A. D., Bachoo, R. M., Takahashi, M. Tags: Biological Sciences Source Type: research

A phase I trial of MK‐2206 in children with refractory malignancies: A children's oncology group study
ConclusionsThe recommended pediatric phase 2 dose of MK‐2206 is 45 mg/m2/dose every other day or 120 mg/m2/dose weekly. PK appeared linear over the dose range studied. Pediatr Blood Cancer 2014;9999:1–6. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Maryam Fouladi, John P. Perentesis, Christine L. Phillips, Sarah Leary, Joel M. Reid, Renee M. McGovern, Ashish M. Ingle, Charlotte H. Ahern, Matthew M. Ames, Peter Houghton, L. Austin Doyle, Brenda Weigel, Susan M. Blaney Tags: Research Article Source Type: research

Central neurogenic hyperventilation and renal tubular acidosis in children with pontine gliomas
Central neurogenic hyperventilation (CNH) is a rare neurologic condition that develops secondary to brainstem involvement. Approximately 35 noncomatose patients with CNH have been reported, including 7 with either a diffuse (patients 2–10 in the table) or focal (patient 1 in the table) brainstem glioma.1–7 Although diffuse intrinsic pontine glioma (DIPG) is the most common pediatric brainstem cancer, only 1 case report described a child with DIPG who experienced CNH.6 (Source: Neurology)
Source: Neurology - March 24, 2014 Category: Neurology Authors: Ledet, D., Delos Santos, N. M., Khan, R., Gajjar, A., Broniscer, A. Tags: All Clinical Neurology, Primary brain tumor, All Pediatric CLINICAL/SCIENTIFIC NOTES Source Type: research

Glutamate quantification in patients with supratentorial gliomas using chemical shift imaging
This study aimed to evaluate and validate chemical shift imaging (CSI) for in vivo glutamate (Glu) quantification in patients with supratentorial gliomas. If validated, CSI could become an extremely useful tool to investigate metabolic dysfunction of Glu in excitotoxic neuropathologies. Quantitative CSI estimates of Glu concentrations were compared with known concentrations of Glu in aqueous phantom solutions. Forty‐one patients with known or likely supratentorial gliomas underwent preoperative CSI. The spectra obtained were analyzed for Glu concentrations and Glu to creatine (Cr) ratios. These in vivo measurements were ...
Source: NMR in Biomedicine - March 24, 2014 Category: Radiology Authors: S. V. Liubinas, K. J. Drummond, P. M. Desmond, A. Bjorksten, A. P. Morokoff, A. H. Kaye, T. J. O'Brien, B. A. Moffat Tags: Research article Source Type: research

Low-Grade Gliomas.
Abstract Low-grade gliomas (LGGs) are a diverse group of primary brain tumors that often arise in young, otherwise healthy patients and generally have an indolent course with longer-term survival in comparison with high-grade gliomas. Treatment options include observation, surgery, radiation, chemotherapy, or a combined approach, and management is individualized based on tumor location, histology, molecular profile, and patient characteristics. Moreover, in this type of brain tumor with a relatively good prognosis and prolonged survival, the potential benefits of treatment must be carefully weighed against potentia...
Source: The Oncologist - March 24, 2014 Category: Cancer & Oncology Authors: Forst DA, Nahed BV, Loeffler JS, Batchelor TT Tags: Oncologist Source Type: research

Novel frame-shift mutations of GLI3 gene in non-syndromic postaxial polydactyly patients.
In this study, we assembled a cohort of individuals of Chinese ethnicity with non-syndromic postaxial polydactyly. We presented the clinical features and molecular evaluations of 19 probands. GLI3 mutations were identified in 15.8% of probands (3/19) including two novel frame-shift mutations c.3855dupC (p.Met1286HisfsTer18) and c.4141delA (p.Arg1381GlyfsTer38) detected in sporadic cases and one previously reported nonsense mutation (c.1927C>T/p.Arg643Ter) in a familial case. Of note, GLI3 mutations were exclusively detected in patients with bilateral polydactyly affecting both hands and feet. Three out of five (60%) pro...
Source: International Journal of Clinical Chemistry - March 22, 2014 Category: Chemistry Authors: Wang Z, Wang J, Li Y, Geng J, Fu Q, Xu Y, Shen Y Tags: Clin Chim Acta Source Type: research

Funding Announcement: Career Development Award - Specialized Program of Research Excellence (SPORE) in Brain Cancer
REQUEST FOR APPLICATIONS CAREER DEVELOPMENT AWARD Specialized Program of Research Excellence (SPORE) in Brain Cancer The Neuro-Oncology Program at the Dana-Farber/Harvard Cancer Center (DF/HCC) is seeking applications for career development projects focused on adult or pediatric gliomas. Funding will be provided through the National Cancer Institute (NCI)-sponsored Specialized Program of Research Excellence (SPORE) mechanism. Eligible candidates are those who are in the final year of clinical fellowship or postdoctoral fellowship (M.D., Ph.D. or equivalent rank are required) or are within 5 years of their first faculty ap...
Source: DF/HCC: Latest News - March 21, 2014 Category: Cancer & Oncology Tags: IECD Source Type: news

Funding Announcement: Developmental Research Award - Specialized Program of Research Excellence (SPORE) in Brain Cancer
REQUEST FOR APPLICATIONS DEVELOPMENTAL RESEARCH AWARD Specialized Program of Research Excellence (SPORE) in Brain Cancer The Neuro-Oncology Program at the Dana-Farber/Harvard Cancer Center (DF/HCC) is seeking applications for developmental research projects focused on adult or pediatric gliomas. Funding will be provided through the National Cancer Institute (NCI)-sponsored Specialized Program of Research Excellence (SPORE) mechanism. Applicants must be faculty members of Harvard Medical School at the level of Instructor or higher. While the proposed research may be basic or clinical, bench-to-bedside or bedside-to-bench st...
Source: DF/HCC: Latest News - March 21, 2014 Category: Cancer & Oncology Tags: IECD Source Type: news

Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma
Conclusion: Overexpression of ENO1 is associated with glioma progression. Knockdown of ENO1 expression led to suppressed cell growth, migration and invasion progression by inactivating the PI3K/Akt pathway in glioma cells. (Source: Molecular Cancer)
Source: Molecular Cancer - March 21, 2014 Category: Cancer & Oncology Authors: Ye SongQisheng LuoHao LongZheng HuTianshi QueXi¿an ZhangZhiyong LiGang WangLiu YiZhen LiuWeiYi FangSongtao Qi Source Type: research

Association of dorsal inferior frontooccipital fasciculus fibers in the deep parietal lobe with both reading and writing processes: a brain mapping study.
Abstract Alexia and agraphia are disorders common to the left inferior parietal lobule, including the angular and supramarginal gyri. However, it is still unclear how these cortical regions interact with other cortical sites and what the most important white matter tracts are in relation to reading and writing processes. Here, the authors present the case of a patient who underwent an awake craniotomy for a left inferior parietal lobule glioma using direct cortical and subcortical electrostimulation. The use of subcortical stimulation allowed identification of the specific white matter tracts associated with readin...
Source: Journal of Neurosurgery - March 21, 2014 Category: Neurosurgery Authors: Motomura K, Fujii M, Maesawa S, Kuramitsu S, Natsume A, Wakabayashi T Tags: J Neurosurg Source Type: research

Simultaneous subependymomas in monozygotic female twins: further evidence for a common genetic or developmental disorder background.
Abstract In this paper, a rare case of subependymoma of the fourth ventricle in identical female twins is reported. Magnetic resonance imaging and CT showed nearly identical locations of the tumors in the fourth ventricle and similar growth patterns of the tumors in both sisters. Likewise, postoperative histopathological analysis of both tumors revealed the typical histological appearance of subependymomas. Subependymoma is a rare, low-grade glioma of the CNS, slowly growing and usually asymptomatic. If symptomatic, a subependymoma can in some cases lead to sudden death caused by pressure on the brainstem or decomp...
Source: Journal of Neurosurgery - March 21, 2014 Category: Neurosurgery Authors: Noell S, Beschorner R, Bisdas S, Beyer U, Weber RG, Fallier-Becker P, Ritz R Tags: J Neurosurg Source Type: research

Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells.
CONCLUSION: These data collectively demonstrate that CMV-specific T cells can effectively target glioblastoma tumor cells for immunologic killing and support the rationale for the development of CMV-directed immunotherapy in patients with GBM. PMID: 24658154 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 21, 2014 Category: Cancer & Oncology Authors: Nair SK, De Leon G, Boczkowski D, Schmittling R, Xie W, Staats J, Liu R, Johnson LA, Weinhold K, Archer GE, Sampson JH, Mitchell DA Tags: Clin Cancer Res Source Type: research

Investigation of the effects of single-nucleotide polymorphisms in DNA repair genes on the risk of glioma.
In conclusion, the results of our study suggest that the rs25487, rs25489, rs1799793, and rs13181 SNPs are associated with an increased risk of glioma. These findings may be useful for identifying the genetic factors involved in the development of glioma to help devise more efficient strategies to prevent this disease. PMID: 24634177 [PubMed - in process] (Source: Genetics and Molecular Research)
Source: Genetics and Molecular Research - March 20, 2014 Category: Genetics & Stem Cells Authors: Gao K, Mu SQ, Wu ZX Tags: Genet Mol Res Source Type: research

Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases
Background: Primary and secondary brain cancers are highly treatment resistant, and their marked angiogenesis attracts interest as a potential therapeutic target. Recent observations reveal that the microvascular endothelium of primary high-grade gliomas expresses prostate specific membrane antigen (PSMA). Breast cancers express PSMA and they frequently form secondary brain tumors. Hence we report here our pilot study addressing the feasibility of PSMA targeting in brain and metastatic breast tumors, by examining PSMA levels in all glioma grades (19 patients) and in breast cancer brain metastases (5 patients). Methods: Tum...
Source: Epidemiologic Perspectives and Innovations - March 20, 2014 Category: Epidemiology Authors: Natsuko NomuraSandra PastorinoMarco GymnopoulosPengfei JiangGage LambertJohn R CrawfordDavid PiccioniTiffany JuarezSandeep C PingleMilan MakaleSantosh Kesari Source Type: research

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
Conclusions: miR-566 activated EGFR signaling and its inhibition sensitized glioblastoma cells to anti-EGFR therapy. (Source: Molecular Cancer)
Source: Molecular Cancer - March 20, 2014 Category: Cancer & Oncology Authors: Kai-Liang ZhangXuan ZhouLei HanLu-Yue ChenLing-Chao ChenZhen-Dong ShiMing YangYu RenJing-Xuan YangThomas FrankChuan-Bao ZhangJun-Xia ZhangPei-Yu PuJian-Ning ZhangTao JiangEric WagnerMin LiChun-Sheng Kang Source Type: research

p75NTR Regulates BTIC Proliferation [Molecular Bases of Disease]
Malignant gliomas are highly invasive, proliferative, and resistant to treatment. Previously, we have shown that p75 neurotrophin receptor (p75NTR) is a novel mediator of invasion of human glioma cells. However, the role of p75NTR in glioma proliferation is unknown. Here we used brain tumor-initiating cells (BTICs) and show that BTICs express neurotrophin receptors (p75NTR, TrkA, TrkB, and TrkC) and their ligands (NGF, brain-derived neurotrophic factor, and neurotrophin 3) and secrete NGF. Down-regulation of p75NTR significantly decreased proliferation of BTICs. Conversely, exogenouous NGF stimulated BTIC proliferation thr...
Source: Journal of Biological Chemistry - March 20, 2014 Category: Chemistry Authors: Forsyth, P. A., Krishna, N., Lawn, S., Valadez, J. G., Qu, X., Fenstermacher, D. A., Fournier, M., Potthast, L., Chinnaiyan, P., Gibney, G. T., Zeinieh, M., Barker, P. A., Carter, B. D., Cooper, M. K., Kenchappa, R. S. Tags: Neurobiology Source Type: research

The PGI-KLF4 pathway regulates self-renewal of glioma stem cells residing in the mesenchymal niches in human gliomas.
Abstract Gliomas display cellular hierarchies with self-renewing tumorigenic glioma stem cells (GSCs) at the apex. The GSC niches function as a regulator of GSC maintenance, however, the exact components of GSC niches that mediate this process are still far from fully defined. Here, we showed that glioma cells with aberrant mesenchymal phenotypes constitute a mesenchymal niche for GSCs. Using patient-derived specimens, we demonstrated that the paracrine PGI signaling, initiated by mesenchymal glioma cells, induces the self-renewal and tumorigenic potentials of GSCs through induction of KLF4. Treatment of intrac...
Source: Neoplasma - March 20, 2014 Category: Cancer & Oncology Authors: Zhu L XY, Luan SH, Zhang HS, Huang WT, Wang NH Tags: Neoplasma Source Type: research

Differential reorganization of three syntax-related networks induced by a left frontal glioma
The opercular/triangular parts of the left inferior frontal gyrus and the left lateral premotor cortex are critical in syntactic processing. We have recently indicated that a glioma in one of these regions is sufficient to cause agrammatic comprehension. In the present study, we aimed to show how normally existing syntax-related networks are functionally reorganized by a lesion. Twenty-one patients with a left frontal glioma preoperatively performed a picture–sentence matching task, and underwent functional magnetic resonance imaging scans in an event-related design. We established two qualitatively different types o...
Source: Brain - March 19, 2014 Category: Neurology Authors: Kinno, R., Ohta, S., Muragaki, Y., Maruyama, T., Sakai, K. L. Tags: Original Articles Source Type: research

Expression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors
Conclusions: These data suggest that HERV-K splice products do not play a role in human malignant gliomas and therefore, are not suitable as targets for new therapy regimen. (Source: BMC Research Notes)
Source: BMC Research Notes - March 19, 2014 Category: Research Authors: Almuth KesslerMiriam WiesnerJoachim DennerUlrike KämmererGiles VinceThomas LinsenmannMario LöhrRalf-Ingo ErnestusCarsten Hagemann Source Type: research

Expression-analysis of the human endogenous retrovirus HERV-K in human astrocytic tumors
Conclusions: These data suggest that HERV-K splice products do not play a role in human malignant gliomas and therefore, are not suitable as targets for new therapy regimen. (Source: BMC Research Notes)
Source: BMC Research Notes - March 19, 2014 Category: Research Authors: Almuth KesslerMiriam WiesnerJoachim DennerUlrike KämmererGiles VinceThomas LinsenmannMario LöhrRalf-Ingo ErnestusCarsten Hagemann Source Type: research

TIMP-1 Modulates Chemotaxis of Human Neural Stem Cells Through CD63 and Integrin Signaling
In this study, we used microarray and proteomics analyses to identify a novel chemoattractant molecule, tissue inhibitor of metalloproteinase-1 (TIMP-1), secreted from human brain tumor tissues. We demonstrate that TIMP-1 significantly enhances hNSC adhesion and migration in a cell culture system. These effects were critically dependent on CD63, as short hairpin RNA-mediated ablation of CD63 expression attenuated the response. TIMP-1 significantly increased the number of focal adhesions (FAs) and cytoskeletal reorganization for cell migration in hNSCs, whereas knockdown of CD63 resulted in decreased hNSC spreading, FAs, an...
Source: BJ Cell - March 18, 2014 Category: Biochemistry Authors: S Lee, J Kim, S Cho, H Kim, H Shin, J Jeon, R Kausar, S Jeong, Y Lee, M Lee Tags: BJ Cell Source Type: research

Palladium(II) complexes with N‐heteroaromatic bidentate hydrazone ligands: the effect of the chelate ring size and lipophilicity on in vitro cytotoxic activity
This article is protected by copyright. All rights reserved. The effect of the chelate ring size and complex lipophilicity on in vitro cytotoxic activity of Pd(II) complexes with NN bidentate N‐heteroaromatic hydrazones was investigated. It was shown that more lipophilic complexes with quinoline backbone were more potent in the cytotoxic action than pyridine analogues. The cytotoxicity of most efficient novel Pd(II) complex 1 is comparable to the activity of cisplatin in all cell lines investigated, and is predominantly mediated through induction of apoptotic cell death. (Source: Chemical Biology and Drug Design)
Source: Chemical Biology and Drug Design - March 18, 2014 Category: Biology Authors: Nenad Filipović, Sonja Grubišić, Maja Jovanović, Marija Dulović, Ivanka Marković, Olivera Klisurić, Aleksandar Marinković, Dragana Mitić, Katarina Anđelković, Tamara Todorović Tags: Research Article Source Type: research

TIMP-1 Modulates Chemotaxis of Human Neural Stem Cells Through CD63 and Integrin Signaling.
In this study, we used microarray and proteomics analyses to identify a novel chemoattractant molecule, tissue inhibitor of metalloproteinase-1 (TIMP-1), secreted from human brain tumor tissues. We demonstrate that TIMP-1 significantly enhances hNSC adhesion and migration in a cell culture system. These effects were critically dependent on CD63, as short hairpin RNA-mediated ablation of CD63 expression attenuated the response. TIMP-1 significantly increased the number of focal adhesions (FAs) and cytoskeletal reorganization for cell migration in hNSCs, whereas knockdown of CD63 resulted in decreased hNSC spreading, FAs, an...
Source: The Biochemical Journal - March 18, 2014 Category: Biochemistry Authors: Lee SY, Kim JM, Cho SY, Kim HS, Shin HS, Jeon JY, Kausar R, Jeong SY, Lee YS, Lee MA Tags: Biochem J Source Type: research

Astrocytic JWA Expression is Essential to Dopaminergic Neuron Survival in the Pathogenesis of Parkinson's Disease.
CONCLUSIONS: The JWA gene exerts neuroprotective roles against DA neuronal degeneration via modulating intracellular redox status and NF-κB signaling pathway and is a potential treatment target for PD. PMID: 24628733 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 17, 2014 Category: Neuroscience Authors: Miao SH, Sun HB, Ye Y, Yang JJ, Shi YW, Lu M, Hu G, Zhou JW Tags: CNS Neurosci Ther Source Type: research

Impacts of MR spectroscopic imaging on glioma patient management.
Abstract Magnetic resonance (MR) modalities are routine imaging tools in the diagnosis and management of gliomas. MR spectroscopic imaging (MRSI), which relies on the metabolic characteristics of tissues, has been developed to accelerate the understanding of gliomas and to aid in effective clinical decision making and development of targeted therapies. In this review, the potentials and practical challenges to frequently use this technique in clinical management of gliomas are discussed. The applications of new biomarkers detectable by MRSI in differential glioma diagnosis, pre- and post-treatment evaluations, and ...
Source: Acta Oncologica - March 16, 2014 Category: Cancer & Oncology Authors: Chronaiou I, Stensjøen AL, Sjøbakk TE, Esmaeili M, Bathen TF Tags: Acta Oncol Source Type: research

Increased Expression of Capn4 is Associated with the Malignancy of Human Glioma.
CONCLUSION: The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma. PMID: 24628706 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - March 15, 2014 Category: Neuroscience Authors: Cai JJ, Qi ZX, Hua W, Zhu JJ, Zhang X, Yao Y, Mao Y Tags: CNS Neurosci Ther Source Type: research

Arterial Spin-Labeling Assessment of Normalized Vascular Intratumoral Signal Intensity as a Predictor of Histologic Grade of Astrocytic Neoplasms [BRAIN]
CONCLUSIONS: The inversion time by which to differentiate high-grade and low-grade astrocytomas by use of normalized vascular intratumoral signal intensity was 370 ms in our study. The normalized vascular intratumoral signal intensity values at this inversion time mainly reflect the labeled intra-arterial blood bolus and therefore could be referred to as normalized vascular intratumoral signal intensity. Our data indicate that the use of normalized vascular intratumoral signal intensity values allows differentiation between low-grade and high-grade astrocytomas and thus may serve as a new, noninvasive marker for astrocytom...
Source: American Journal of Neuroradiology - March 13, 2014 Category: Radiology Authors: Furtner, J., Schopf, V., Schewzow, K., Kasprian, G., Weber, M., Woitek, R., Asenbaum, U., Preusser, M., Marosi, C., Hainfellner, J. A., Widhalm, G., Wolfsberger, S., Prayer, D. Tags: BRAIN Source Type: research

Id2 Is Tumorigenic in a PDGF-Rich Microenvironment
Maturation defects occurring in adult tissue progenitor cells have the potential to contribute to tumor development; however, there is little experimental evidence implicating this cellular mechanism in the pathogenesis of solid tumors. Inhibitor of DNA-binding 2 (Id2) is a transcription factor known to regulate the proliferation and differentiation of primitive stem and progenitor cells. Id2 is derepressed in adult tissue neural stem cells (NSC) lacking the tumor suppressor Tp53 and modulates their proliferation. Constitutive expression of Id2 in differentiating NSCs resulted in maturation-resistant oligodendroglial precu...
Source: Cancer Research - March 13, 2014 Category: Cancer & Oncology Authors: Havrda, M. C., Paolella, B. R., Ran, C., Jering, K. S., Wray, C. M., Sullivan, J. M., Nailor, A., Hitoshi, Y., Israel, M. A. Tags: Tumor and Stem Cell Biology Source Type: research

BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma
ConclusionBRAF V600E mutation affects a subset of DIAs/DIGs and offers new therapeutic opportunities. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - March 13, 2014 Category: Neurology Authors: C. Koelsche, F. Sahm, W. Paulus, M. Mittelbronn, F. Giangaspero, M. Antonelli, J. Meyer, F. Lasitschka, A. Deimling, D. Reuss Tags: Original article Source Type: research

Tocagen begins dosing in clinical study of investigational cancer therapy
US-based clinical stage biopharmaceutical firm Tocagen has dosed the first patient in its clinical trial investigating the intravenous administration of selective cancer therapy Toca 511 & Toca FC, in patients with recurrent high grade glioma (HGG) i… (Source: Drug Development Technology)
Source: Drug Development Technology - March 12, 2014 Category: Pharmaceuticals Source Type: news

Chiasmal haemorrhage secondary to glioma with unusual MRI appearance.
CONCLUSIONS: We present a unique case of chiasmal bleeding into the optic pathway secondary to an optic glioma which radiologically mimicked an intracisternal cyst. In similar cases, rapid clinical evolution of the symptoms may be vital for the differential diagnosis. Surgery is warranted to prevent permanent damage to the visual pathway. PMID: 24630732 [PubMed - as supplied by publisher] (Source: Neurocirugia)
Source: Neurocirugia - March 12, 2014 Category: Neurosurgery Authors: Arrese I, Sarabia R, Zamora T Tags: Neurocirugia (Astur) Source Type: research

Molecular characterization of long‐term survivors of glioblastoma using genome‐ and transcriptome‐wide profiling
Abstract The prognosis of glioblastoma, the most malignant type of glioma, is still poor, with only a minority of patients showing long‐term survival of more than three years after diagnosis. To elucidate the molecular aberrations in glioblastomas of long‐term survivors, we performed genome‐ and/or transcriptome‐wide molecular profiling of glioblastoma samples from 94 patients, including 28 long‐term survivors with >36 months overall survival (OS), 20 short‐term survivors with <12 months OS, and 46 patients with intermediate OS. Integrative bioinformatic analyses were used to characterize molecular aberra...
Source: International Journal of Cancer - March 11, 2014 Category: Cancer & Oncology Authors: Guido Reifenberger, Ruthild G. Weber, Vera Riehmer, Kerstin Kaulich, Edith Willscher, Henry Wirth, Jens Gietzelt, Bettina Hentschel, Manfred Westphal, Matthias Simon, Gabriele Schackert, Johannes Schramm, Jakob Matschke, Michael C. Sabel, Dorothee Gramatz Tags: Cancer Genetics Source Type: research

Silent diffuse low‐grade glioma: Toward screening and preventive treatment?
We show that people with a silent gliomas have more chances to die from their gliomas than from another unrelated cause. This result, combined with the knowledge that diffuse low‐grade gliomas remain clinically silent for very long period (>10 years), grounds the screening and preventive treatment of silent diffuse low‐grade glioma. (Source: Cancer)
Source: Cancer - March 11, 2014 Category: Cancer & Oncology Authors: Emmanuel Mandonnet, Philip Witt Hamer, Johan Pallud, Luc Bauchet, Ian Whittle, Hugues Duffau Tags: Commentary Source Type: research

Ganglion Cell Layer-Inner Plexiform Layer Thickness and Vision Loss in Young Children With Optic Pathway Gliomas [Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology]
Conclusions. Decreased GCL-IPL thickness (<fifth percentile) can discriminate between children with and without vision loss from their OPG. Ganglion cell layer–inner plexiform layer thickness could be used as a surrogate marker of vision in children with OPGs. (Source: Investigative Ophthalmology)
Source: Investigative Ophthalmology - March 10, 2014 Category: Opthalmology Authors: Gu, S., Glaug, N., Cnaan, A., Packer, R. J., Avery, R. A. Tags: Eye Movements, Strabismus, Amblyopia, and Neuro-Ophthalmology Source Type: research

Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: effects of genistein, quercetin and buthionine-sulfoximine.
In conclusion, in C6 cells neither genistein nor quercetin are suited as sensitizing agent, in contrast to BSO. Depletion of cellular glutathione content rather than an increase of ROS generation plays a central role in the enhancement of ATO-toxicity in C6 cells. PMID: 24632069 [PubMed - as supplied by publisher] (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 10, 2014 Category: Food Science Authors: Klauser E, Gülden M, Maser E, Seibert S, Seibert H Tags: Food Chem Toxicol Source Type: research

Endothelial Cells Promote Stem‐like Phenotype of Glioma Cells through Activating Hedgehog Pathway
Abstract Microenvironmental regulation of cancer stem cells (CSCs) strongly influences onset and spread of cancer. The way in which glioma cells interact with their microenvironment and acquire the phenotypes of CSCs remains elusive. We investigated how communication between vascular endothelial cells and glioma cells promoted the properties of glioma stem cells (GSCs). We observed that CD133+ GSCs were located closely to Shh + endothelial cells in the specimens of human primary glioblastoma multiforme (GBM). In both in vitro and in vivo studies, we found that endothelial cells promoted the appearance of CSC‐like gli...
Source: The Journal of Pathology - March 7, 2014 Category: Pathology Authors: Guang‐ning Yan, Lang Yang, Yang‐fan Lv, Yu Shi, Li‐li Shen, Xiao‐hong Yao, Qiao‐nan Guo, Peng Zhang, You‐hong Cui, Xia Zhang, Xiu‐wu Bian, De‐yu Guo Tags: Original Paper Source Type: research

Sulfasalazine and temozolomide with radiation therapy for newly diagnosed glioblastoma
Conclusions: Sulfasalazine treatment with temozolomide plus radiotherapy for newly diagnosed primary GBM is associated with a high rate of discontinuation due to hematologic toxic effects. This treatment may have no effect on OS or PFS, although it may improve seizure control if an adequate dose can be administered. (Source: Neurology India)
Source: Neurology India - March 7, 2014 Category: Neurology Authors: Satoru TakeuchiKojiro WadaKimihiro NagataniNaoki OtaniHideo OsadaHiroshi Nawashiro Source Type: research