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Assessment of 1p/19q status by fluorescence <i>in situ</i> hybridization assay: A comparative study in oligodendroglial, mixed oligoastrocytic and astrocytic tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion</b> : Loss of 1p/19q is strongly associated with oligodendroglial phenotype, while astrocytic tumors are more likely to show p53 over-expression. p53 expression and 1p/19q status appear to be mutually exclusive. (Source: Neurology India)
Source: Neurology India - November 20, 2009 Category: Neurology Authors: Shukla Bhaskar, Agarwal Shipra, Suri Vaishali, Pathak Pankaj, Sharma Mehar Chand, Gupta Deepak, Sharma Bhavani Shankar, Suri Ashish, Halder Ashutosh, Sarkar Chitra Source Type: journals

Cytotoxic Effects of Temozolomide and Radiation are Additive- and Schedule-DependentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: TMZ is not a radiosensitizing agent but yields additive cytotoxicity in combination with radiation. Our data indicate that TMZ treatment should commence at least 3 days before radiation to achieve maximum benefit. Activation of G2/M checkpoint signaling by TMZ and radiation has a cytoprotective effect that can be overcome by dual inhibition of ATM and ATR. More specific inhibition of checkpoint signaling will be required to increase treatment efficacy without exacerbating toxicity. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Anthony J. Chalmers, Elliot M. Ruff, Christine Martindale, Nadia Lovegrove, Susan C. Short Tags: Biology Contributions Source Type: journals

Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimuriumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that S. typhimurium A1-R monotherapy can effectively treat spinal cord glioma. (Source: Cell Proliferation)
Source: Cell Proliferation - November 19, 2009 Category: Cytology Authors: H. Kimura, L. Zhang, M. Zhao, K. Hayashi, H. Tsuchiya, K. Tomita, M. Bouvet, J. Wessels, R. M. Hoffman Source Type: journals

The novel ruthenium - [gamma]-linolenic complex [Ru2(aGLA)4Cl] inhibits C6 rat glioma cell proliferation and induces changes in mitochondrial membrane potential, increased reactive oxygen species generation and apoptosis in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present study reports the synthesis of a novel compound with the formula [Ru2(aGLA)4Cl] according to elemental analyses data, referred to as Ru2GLA. The electronic spectra of Ru2GLA is typical of a mixed valent diruthenium(II,III) carboxylate. Ru2GLA was synthesized with the aim of combining and possibly improving the anti-tumour properties of the two active components ruthenium and [gamma]-linolenic acid (GLA). The properties of Ru2GLA were tested in C6 rat glioma cells by analysing cell number, viability, lipid droplet formation, apoptosis, cell cycle distribution, mitochondrial membrane potential and reactive oxygen...
Source: Cell Biochemistry and Function - November 19, 2009 Category: Biochemistry Authors: Geise Ribeiro, Marcel Benadiba, Denise de Oliveira Silva, Alison Colquhoun Source Type: journals

Functional Modulation of Mitochondria by Eicosapentaenoic Acid Provides Protection against Ceramide Toxicity to C6 Glioma CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - November 18, 2009 Category: Food Science Tags: article Source Type: journals

Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resveratrol (3,4',5-trans-trihydroxystilbene) and other hydroxystilbenes exhibit in vitro antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage. The prooxidant effects are held likely to be responsible for their cytotoxic, anti-proliferative or pro-apoptotic effects observed in vitro. Regarding antioxidant/prooxidant activities in the past various studies were performed aiming at defining structure-activity relationships for hydroxystilbenes using cell-free systems. In the present study cultured C6 glioma cells were used in ord...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Rüweler M, Gülden M, Maser E, Murias M, Seibert H Tags: Chem Biol Interact Source Type: journals

Snail and Cox-2 expressions are associated with WHO tumor grade and survival rate of patients with gliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, Snail and Cox-2 expressions were associated with WHO grade in gliomas and may be used as prognostic indicators. (Source: Neuropathology)
Source: Neuropathology - November 18, 2009 Category: Neurology Authors: Jaekyung Myung, Byung-Kyu Cho, Young-Soon Kim, Sung-Hye Park Source Type: journals

Clinical and Mutational Spectrum of Neurofibromatosis Type 1-like Syndrome [Original Contribution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A high SPRED1 mutation detection rate was found in NF1 mutation–negative families with an autosomal dominant phenotype of CALMs with or without freckling and no other NF1 features. Among individuals in this study, NFLS was not associated with the peripheral and central nervous system tumors seen in NF1. (Source: JAMA)
Source: JAMA - November 17, 2009 Category: Journals (General) Authors: Messiaen, L., Yao, S., Brems, H., Callens, T., Sathienkijkanchai, A., Denayer, E., Spencer, E., Arn, P., Babovic-Vuksanovic, D., Bay, C., Bobele, G., Cohen, B. H., Escobar, L., Eunpu, D., Grebe, T., Greenstein, R., Hachen, R., Irons, M., Kronn, D., Lemire Tags: Neurology, Neurogenetics, Neurocutaneous Diseases, Neuromuscular diseases, Diagnosis, Genetics, Genetic Disorders Original Contribution Source Type: journals

Bevacizumab for recurrent ependymomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The radiographic response rate to bevacizumab-containing regimens is high. A prospective study is warranted. (Source: Neurology)
Source: Neurology - November 16, 2009 Category: Neurology Authors: Green, R. M., Cloughesy, T. F., Stupp, R., DeAngelis, L. M., Woyshner, E. A., Ney, D. E., Lassman, A. B. Tags: All Oncology, Primary brain tumor, Spinal cord tumor, Chemotherapy-tumor ARTICLES Source Type: journals

Goldhirsh Foundation 2010 Grant Cycle of the Brain Tumor Research Awards ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Goldhirsh Foundation is pleased to announce the 2010 Grant Cycle of the Brain Tumor Research Awards Program. The next application deadline is Thursday, January 7, 2010, 12:00 Noon, U.S. and Canada Eastern Time (GMT-5) for awards beginning on July 1, 2010. The Goldhirsh Foundation was established by Bernard A. Goldhirsh in 2000, shortly after he was diagnosed with brain cancer. Since his death in 2003, the Board of Directors of the Foundation (which includes his two children) has been shaping a grantmaking program that reflects his values and entrepreneurial spirit. We are dedicated to making a difference in the lives ...
Source: ScanGrants feed - November 15, 2009 Category: Research Authors: Goldhirsh Foundation Source Type: funding

S-Adenosylhomocysteine Promotes the Invasion of C6 Glioma Cells via Increased Secretion of Matrix Metalloproteinase-2 in Murine Microglial BV2 CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined the hypothesis that SAH may indirectly enhance the invasion of C6 glioma cells by induction of matrix metalloproteinase-2 (MMP-2) secreted from the murine microglia BV2 cells. We obtained conditioned medium (CM) by incubating BV2 cells with SAH (1–50nM) for 24 h. We found that the SAH-containing CM (SAH-BV2-CM) strongly enhanced the invasiveness of C6 glioma cells and that this effect increased with increasing concentrations of SAH in the SAH-BV2-CM. The effect of CM could be attributed to its MMP-2 activity, as a result of increased protein and messenger RNA expression of MMP-2 in BV2 cell...
Source: Toxicological Sciences - November 13, 2009 Category: Toxicology Authors: Lin, H.-C., Song, T.-Y., Hu, M.-L. Tags: CARCINOGENICITY Source Type: journals

An Automatic Procedure for Normalization of Cerebral Blood Volume Maps in Dynamic Susceptibility Contrast-Based Glioma Imaging [BRAIN]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY: To characterize gliomas from dynamic susceptibility contrast (DSC)–based cerebral blood volume (CBV) maps, a CBV value from a normal-appearing region of interest is typically identified manually and used to normalize the CBV maps. This method is user-dependent and time-consuming. We propose an alternative approach based on automatic identification of normal-appearing first-pass curves from brain tissue. Our results in 101 patients suggest similar or better diagnostic accuracy values than the manual approach. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - November 13, 2009 Category: Radiology Authors: Emblem, K.E., Bjornerud, A. Tags: BRAIN Source Type: journals

The Dexamethasone-induced Inhibition of Proliferation, Migration, and Invasion in Glioma Cell Lines Is Antagonized by Macrophage Migration Inhibitory Factor (MIF) and Can Be Enhanced by Specific MIF Inhibitors [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and sho...
Source: Journal of Biological Chemistry - November 13, 2009 Category: Chemistry Authors: Piette, C., Deprez, M., Roger, T., Noel, A., Foidart, J.-M., Munaut, C. Tags: Mechanisms Of Signal Transduction Source Type: journals

Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we investigated the status of FOXO3a expression and related signaling in human glioma in order to test its potential value as a therapeutic target for this disease. Immunohistochemistry, western blot, RT-PCR, and immunofluorescence staining analysis were performed on specimens from 70 cases of human glioma and on U87MG and T98G glioma cells. Our data showed FOXO3a expression is directly correlated with the malignant grade of glioma. More importantly, low expression of FOXO3a was associated with poor patient outcome. In vitro, FOXO3a modulated the cell cycle by transcriptional regulation of p27kip1. Admin...
Source: Journal of Neuro-Oncology - November 13, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

Loss of Collapsin Response Mediator Protein1, as Detected by iTRAQ Analysis, Promotes Invasion of Human Gliomas Expressing Mutant EGFRvIIIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glioblastoma multiforme (GBM) is the most common and lethal primary human brain tumor. GBMs are characterized by a variety of genetic alterations, among which oncogenic mutations of epidermal growth factor receptor (EGFRvIII) is most common. GBMs harboring EGFRvIII have increased proliferation and invasive characteristics versus those expressing wild-type (wt) EGFR. To identify the molecular basis of this increased tumorgenic phenotype, we used iTRAQ-labeling differential proteomic analysis. Among several differentially expressed proteins, we selected CRMP1, a protein implicated in cellular invasion that was markedly decre...
Source: Cancer Research - November 12, 2009 Category: Cancer & Oncology Authors: Mukherjee, J., DeSouza, L. V., Micallef, J., Karim, Z., Croul, S., Siu, K.W. M., Guha, A. Tags: Cell, Tumor, and Stem Cell Biology Source Type: journals

Simultaneous Use of Functional Tractography, Neuronavigation-Integrated Subcortical White Matter Stimulation and Intraoperative Magnetic Resonance Imaging in Glioma Surgery: Technical NoteEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stereotact Funct Neurosurg 2009;87:395-398 (DOI:10.1159/000258080) (Source: Karger Publishers)
Source: Karger Publishers - November 11, 2009 Category: Cancer & Oncology Source Type: journals

Hypoxia-inducible factor-1α blocks differentiation of malignant gliomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aberrant differentiation is a characteristic feature of neoplastic transformation, while hypoxia in solid tumors is believed to be linked to aggressive behavior and poor prognosis. However, the possible relationship between hypoxia and differentiation in malignancies remains poorly defined. Here we show that rat C6 and primary human malignant glioma cells can be induced to differentiate into astrocytes by the well-known adenylate cyclase activator forskolin. However, hypoxia-inducible factor-1[alpha] expression stimulated by the hypoxia mimetics cobalt chloride or deferoxamine blocks this differentiation and this effective...
Source: FEBS Journal - November 11, 2009 Category: Research Authors: Huimin Lu, Yan Li, Minfeng Shu, Jianjun Tang, Yijun Huang, Yuxi Zhou, Yingjie Liang, Guangmei Yan Source Type: journals

Protective effect of verbascoside in activated C6 glioma cells: possible molecular mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The glycosylated phenylpropanoid verbascoside (VB), isolated from cultured cells of the medicinal plant Syringa vulgaris (Oleaceae), has previously been characterized as an effective scavenger of biologically active free radicals and an inhibitor of lipid peroxidation. The aim of the present study was to evaluate in a rat glioma cell line (C6) the effect of VB biotechnologically produced by S. vulgaris plant cell cultures in the regulation of the inflammatory response. We used a model of central nervous system inflammation induced by bacterial endotoxin/cytokine (lipopolysaccharide (LPS)/interferon (...
Source: Naunyn-Schmiedeberg's Archives of Pharmacology - November 10, 2009 Category: Drugs & Pharmacology Tags: Naunyn-Schmiedeberg's Archives of Pharmacology Source Type: journals

Nimotuzumab in pediatric gliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Future Oncology , November 2009, Vol. 5, No. 9, Pages 1349-1361. (Source: Future Oncology)
Source: Future Oncology - November 10, 2009 Category: Cancer & Oncology Tags: article Source Type: journals

Loss of Collapsin Response Mediator Protein1, as Detected by iTRAQ Analysis, Promotes Invasion of Human Gliomas Expressing Mutant EGFRvIII.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glioblastoma multiforme (GBM) is the most common and lethal primary human brain tumor. GBMs are characterized by a variety of genetic alterations, among which oncogenic mutations of epidermal growth factor receptor (EGFRvIII) is most common. GBMs harboring EGFRvIII have increased proliferation and invasive characteristics versus those expressing wild-type (wt) EGFR. To identify the molecular basis of this increased tumorgenic phenotype, we used iTRAQ-labeling differential proteomic analysis. Among several differentially expressed proteins, we selected CRMP1, a protein implicated in cellular invasion that was markedly d...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Mukherjee J, Desouza LV, Micallef J, Karim Z, Croul S, Siu KW, Guha A Tags: Cancer Res Source Type: journals

Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines derived from high-grade gliomas, we show that BTSCs are subject to immunologic recognition and elimination by CD8(+) CTLs. Compared with serum-differentiated CD133(low) tumor cells and established glioma cell lines, BTSCs are equivalent with respect to expression levels of HLA class I and ICAM-1, similar in t...
Source: Cell Research - November 10, 2009 Category: Cytology Authors: Brown CE, Starr R, Martinez C, Aguilar B, D'Apuzzo M, Todorov I, Shih CC, Badie B, Hudecek M, Riddell SR, Jensen MC Tags: Cancer Res Source Type: journals

The Importance of Tumor Volume in the Prognosis of Patients with GlioblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Geometric models provide a rough approximation of tumor volume and should not be used, as accurate determination of size is of paramount importance in order to draw safe conclusions in oncology. Although the significance of volumetry was not disclosed, further studies are definitely required. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00066-009-2015-7Authors Georgios Iliadis, “Papageorgiou” General Hospital Department of Radiation Oncology Thessaloniki GreecePanagiotis Selviaridis, Aristotle University of Thessaloniki, School of Medicine Department of Neurosurg...
Source: Strahlentherapie und Onkologie - November 9, 2009 Category: Cancer & Oncology Tags: Strahlentherapie und Onkologie Source Type: journals

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain TumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Heterozygous point mutations of isocitrate dehydrogenase (IDH)1 codon 132 are frequent in grade II and III gliomas. Recently, we reported an antibody specific for the IDH1R132H mutation. Here we investigate the capability of this antibody to differentiate wild type and mutated IDH1 protein in central nervous system (CNS) tumors by Western blot and immunohistochemistry. Results of protein analysis are correlated to sequencing data. In Western blot, anti-IDH1R132H mouse monoclonal antibody mIDH1R132H detected a specific band only in mutated tumors. Immunohistochemistry of 345 primary brain tumors demonstrated a strong cytopl...
Source: Brain Pathology - November 9, 2009 Category: Neurology Authors: David Capper, Susanne Weißert, Jörg Balss, Antje Habel, Jochen Meyer, Diana Jäger, Ulrike Ackermann, Claudia Tessmer, Andrey Korshunov, Hanswalter Zentgraf, Christian Hartmann, Andreas von Deimling Source Type: journals

Detecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that the percent of PBMCs displaying p-STAT-3 may be increased in malignant glioma patients. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 9, 2009 Category: Research Authors: William HumphriesYongtao WangWei QiaoChantal Reina-OrtizMohamed Abou-GhazalLamonne CrutcherJun WeiLing-Yuan KongRaymond SawayaGanesh RaoJeffrey WeinbergSujit PrabhuGregory FullerAmy Heimberger Source Type: journals

Primary spinal cord glioma: a Surveillance, Epidemiology, and End Results database studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To characterize the overall survival (OS) and cause specific survival (CSS), and variables affecting outcome, in patients with primary spinal cord astrocytoma (SCA) and ependymoma (SCE). About 664 patients with SCA and 1,057 patients with SCE were analyzed using the Surveillance, Epidemiology, and End Results database. For grade 1, 2, 3 and 4 SCA, the 5-year OS was 82, 70, 28 and 14%; the 5-year CSS was 89, 77, 36 and 20%. For SCA, lower grade, younger age, and undergoing resection significantly improved OS and CSS; treatment without radiotherapy was favorable for CSS. Smaller tumor size also improv...
Source: Journal of Neuro-Oncology - November 7, 2009 Category: Cancer & Oncology Tags: Journal of Neuro-Oncology Source Type: journals

New Glioma Study Results Reported From University Of IllinoisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to a study from the United States, Malignant gliomas are characterized by invasive and infiltrative behavior that generally involves the destruction of normal brain tissue. Strategies to treat infiltrating gliomas, such as chemotherapy and gene therapy, have remained largely unsuccessful. (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 6, 2009 Category: Cancer & Oncology Source Type: news

Vaccine therapy with dendritic cells transfected with Il13ra2 mRNA for glioma in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These results demonstrate the therapeutic potential of vaccination with dendritic cells transfected with Il13ra2 mRNA for the treatment of malignant glioma. PMID: 19895199 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 6, 2009 Category: Neurosurgery Authors: Saka M, Amano T, Kajiwara K, Yoshikawa K, Ideguchi M, Nomura S, Fujisawa H, Kato S, Fujii M, Ueno K, Hinoda Y, Suzuki M Tags: J Neurosurg Source Type: journals

Imaging of hypoxic lesions in patients with gliomas by using positron emission tomography with 1-(2-[(18)F] fluoro-1-[hydroxymethyl]ethoxy)methyl-2-nitroimidazole, a new (18)F-labeled 2-nitroimidazole analog.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Imaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. This new method can assess tumor hypoxia preoperatively and noninvasively. PMID: 19895196 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - November 6, 2009 Category: Neurosurgery Authors: Shibahara I, Kumabe T, Kanamori M, Saito R, Sonoda Y, Watanabe M, Iwata R, Higano S, Takanami K, Takai Y, Tominaga T Tags: J Neurosurg Source Type: journals

Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite aggressive surgery, radiotherapy, and chemotherapy, treatment of malignant glioma remains formidable. Although the concept of cancer stem cells reveals a new framework of cancer therapeutic strategies against malignant glioma, it remains unclear how glioma stem cells could be eradicated. Here, we demonstrate that autocrine TGF-beta signaling plays an essential role in retention of stemness of glioma-initiating cells (GICs) and describe the underlying mechanism for it. TGF-beta-induced expression of Sox2, a stemness gene, and this induction was mediated by Sox4, a direct TGF-beta target gene. Inhibitors of TGF-b...
Source: Cell Stem Cell - November 6, 2009 Category: Stem Cells Authors: Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, Miyazono K Tags: Cell Stem Cell Source Type: journals

Radiotherapy of malignant gliomas: Comparison of volumetric single arc technique (RapidArc), dynamic intensity-modulated technique and 3D conformal technique.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: If PTV is distant to OAR, the use of 3D conformal technique is sufficient. Otherwise an intensity-modulated technique should be used. RapidArc was faster than conventional IMRT and should be preferred if PTV coverage is adequate. PMID: 19897266 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - November 6, 2009 Category: Radiology Authors: Wagner D, Christiansen H, Wolff H, Vorwerk H Tags: Radiother Oncol Source Type: journals

Use of genetically engineered bone marrow-derived mesenchymal stem cells for glioma gene therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In our previous study, we successfully treated an established C6 brain tumor using neural stem cells transduced with the herpes simplex virus-thymidine kinase gene (HSVtk) and ganciclovir in the rat. In the present study, we investigated the use of mesenchymal stem cells (MSCs), obtained from adult rats and transduced with HSVtk (MSCtk cells), instead of neural stem cells because MSCs are much easier to obtain from the adult subjects. Those cells were used for in vitro co-culture study and in vivo co-implantation study with C6 rat glioma cells to examine bystander tumoricidal effect, which revealed a sufficient bystand...
Source: International Journal of Oncology - November 5, 2009 Category: Cancer & Oncology Authors: Amano S, Li S, Gu C, Gao Y, Koizumi S, Yamamoto S, Terakawa S, Namba H Tags: Int J Oncol Source Type: journals

Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPECT uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: George A. Alexiou, Spyridon Tsiouris, George Vartholomatos, George Fotakopoulos, Athanasios Papadopoulos, Athanasios P. Kyritsis, Spyridon Voulgaris, Andreas D. Fotopoulos Tags: Original articles Source Type: journals

Immunological factors relating to the antitumor effect of temozolomide chemo-immunotherapy in a murine glioma model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the potential of combined treatment with temozolomide (TMZ) chemotherapy and tumor antigen-pulsed dendritic cells (DCs) and the underlying immunological factors of TMZ chemo-immunotherapy in an intracranial GL26 glioma animal model. The combined treatment enhanced the tumor-specific immune responses and prolonged the survival more effectively than either single therapy in GL26 tumor-bearing animals. Apoptosis was induced in the tumor of animals by the treatment with TMZ. Calreticulin (CRT) surface exposure was detected by immunofluorescence staining in TMZ-treated GL26 cells. TMZ chemotherapy...
Source: Clinical and Vaccine Immunology - November 4, 2009 Category: Allergy & Immunology Authors: Kim TG, Kim CH, Park JS, Park SD, Kim CK, Chung DS, Hong YK Tags: Clin Vaccine Immunol Source Type: journals

Fibulin-3 Is Uniquely Upregulated in Malignant Gliomas and Promotes Tumor Cell Motility and Invasion.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malignant gliomas are highly invasive tumors with an almost invariably rapid and lethal outcome. Surgery and chemoradiotherapy fail to remove resistant tumor cells that disperse within normal tissue, which are a major cause for disease progression and therapy failure. Infiltration of the neural parenchyma is a distinctive property of malignant gliomas compared with other solid tumors. Thus, glioma cells are thought to produce unique molecular changes that remodel the neural extracellular matrix and form a microenvironment permissive for their motility. Here, we describe the unique expression and proinvasive role of fib...
Source: Cell Research - November 3, 2009 Category: Cytology Authors: Hu B, Thirtamara-Rajamani KK, Sim H, Viapiano MS Tags: Mol Cancer Res Source Type: journals

Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Bavituximab combined with radiotherapy holds promise as a vascular targeting and immune enhancement strategy for the treatment of human glioblastoma. (Clin Cancer Res 2009;15(22):6871-80). PMID: 19887482 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - November 3, 2009 Category: Cancer & Oncology Authors: He J, Yin Y, Luster TA, Watkins L, Thorpe PE Tags: Clin Cancer Res Source Type: journals

Radiation therapy has good outcomes for pediatric glioma patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of radiation therapy to treat pediatric low-grade glioma, the most commonly diagnosed brain cancer in children, is controversial due to the severe, adverse, late effects this treatment can cause. But the long-term outcomes of patients who participated (more) (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - November 2, 2009 Category: Radiology Source Type: info

Horizon scanning: Conference report of Phase III data for nimotuzumab in children with intrinsic pontine gliomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: BioSpace Area: News BioSpace has reported briefly on data from an open-label single-arm Phase III study of nimotuzumab combined with radiation in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG), presented at the 41st Annual Meeting of the International Society of Pediatric Oncology. The study enrolled 42 patients aged 3 to 16 years (median 7 years) between April 2006 and August 2007, with 41 patients evaluable for response. The primary endpoint is the median progression-free survival (PFS) over six months; secondary endpoints included overall survival, response rate, toxicity and q...
Source: NeLM - Oncology - November 2, 2009 Category: Cancer & Oncology Source Type: organizations

Cancer drug from Cuba undergoes rare U.S. trial (for brainstem glioma as well as GBMs)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - November 1, 2009 Category: Cancer & Oncology Source Type: clinical trials

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors)
Source: Clinical Trials And Noteworthy Treatments For Brain Tumors - November 1, 2009 Category: Cancer & Oncology Source Type: clinical trials