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FDA grants IDE to NovoCure for phase II Optune trial
NovoCure (NSDQ:NVCR) said today that Radiation Therapy Oncology Group Foundation won FDA investigational device exemption to conduct a Phase II pilot test of NovoCure’s Optune in conjunction with bevacizumab to treat bevacizumab-refractory recurrent glioblastoma. The Optune is a mobile device that delivers low-intensity, intermediate frequency, alternating electric fields, referred to as “tumor treating fields” to inhibit cancer cell replication and cause cancer cell death. “This is the 1st consortium study of TTFields, representing a growing interest in TTFields therapy from the scientific commun...
Source: Mass Device - April 25, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Clinical Trials Food & Drug Administration (FDA) Oncology NovoCure Source Type: news

BRI initiates Phase 2 clinical trial of Antineoplastons A10 and AS2-1 in DIPG patients
Burzynski Research Institute (BRI) has started patient enrolment for a Phase 2 study of Antineoplastons A10 and AS2-1 in patients below the age of 3 months with diffuse intrinsic brainstem glioma (DIPG) disease. (Source: Drug Development Technology)
Source: Drug Development Technology - April 15, 2016 Category: Pharmaceuticals Source Type: news

Adding Chemotherapy to Radiotherapy Extends Glioma SurvivalAdding Chemotherapy to Radiotherapy Extends Glioma Survival
For patients with low-grade glioma, progression-free and overall survival are better when chemotherapy is added to radiotherapy, long-term results confirm. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 8, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Radiation therapy chemotherapy combination improves survival in adults with low-grade brain cancer
Patients with a low-grade type of brain tumor called glioma who received radiation therapy plus a chemotherapy regimen, including procarbazine, lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received radiation therapy alone, according to the results of the clinical trial. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 7, 2016 Category: Science Source Type: news

Chemo May Prolong Lives of Some Brain Cancer Patients
Those with slow-growing gliomas lived five years longer, on average, than those who got only radiation Source: HealthDay Related MedlinePlus Pages: Brain Tumors, Cancer Chemotherapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 7, 2016 Category: Consumer Health News Source Type: news

Combo Tx Leads to Survival Benefit in Glioma
(MedPage Today) -- A 5.5-year improvement with chemoradiotherapy versus radiation alone (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 7, 2016 Category: Hematology Source Type: news

Chemo May Prolong Lives of Some With Brain Cancer
Those with slow-growing gliomas lived five years longer, on average, than those who got only radiation (Source: WebMD Health)
Source: WebMD Health - April 7, 2016 Category: Consumer Health News Source Type: news

Chemo May Prolong Lives of Some Brain Cancer Patients: Study
Those with slow-growing gliomas lived five years longer, on average, than those who got only radiation (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 7, 2016 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, News, Source Type: news

Combo Tx Leads to Survival Benefit in Glioma (CME/CE)
(MedPage Today) -- A 5.5-year improvement with chemoradiotherapy versus radiation alone (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 6, 2016 Category: Hematology Source Type: news

Chemo May Prolong Lives of Some Brain Cancer Patients: Study
Those with slow-growing gliomas lived five years longer, on average, than those who got only radiation (Source: U.S. News - Health)
Source: U.S. News - Health - April 6, 2016 Category: Consumer Health News Source Type: news

Adding chemo to radiation boosts survival from low-grade gliomas
Adding a chemotherapy combination to radiation therapy for initial treatment of low-grade gliomas significantly improved overall survival and progression-free survival, regardless of the tumor type,... (Source: Clinical Neurology News)
Source: Clinical Neurology News - April 6, 2016 Category: Neurology Source Type: news

Combined chemotherapy and radiation therapy assists low-grade glial brain tumors
(NRG Oncology) The Radiation Therapy Oncology Group, now conducting research as NRG Oncology, initiated the trial RTOG 9802 (A Phase III Study of Radiation With or Without PCV Chemotherapy in Unfavorable Low-Grade Glioma) in an effort to improve patient survival. NRG Oncology researchers report the long-term results of this randomized clinical trial. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 6, 2016 Category: Cancer & Oncology Source Type: news

Radiation therapy chemotherapy combination improves survival in adults with low-grade brain cancer
(Mayo Clinic) Patients with a low-grade type of brain tumor called glioma who received radiation therapy plus a chemotherapy regimen, including procarbazine, lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received radiation therapy alone, according to the results of the clinical trial, Radiation Therapy Oncology Group (RTOG) 9802 published in the April 7 issue of the New England Journal of Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 6, 2016 Category: Cancer & Oncology Source Type: news

Radiation Therapy Chemotherapy Combination Improves Survival in Adults with Low-Grade Brain Cancer
ROCHESTER, Minn. — Patients with a low-grade type of brain tumor called glioma who received radiation therapy plus a chemotherapy regimen, including procarbazine, lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received radiation therapy alone, according to the results of the clinical trial, Radiation Therapy Oncology Group (RTOG) 9802 [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - April 6, 2016 Category: Hospital Management Source Type: news

Radiation Therapy Chemotherapy Combination Improves Survival in Adults with Low-Grade Brain Cancer
ROCHESTER, Minn. — Patients with a low-grade type of brain tumor called glioma who received radiation therapy plus a chemotherapy regimen, including procarbazine, lomustine and vincristine (PCV), experienced a longer progression-free survival and overall survival than patients who received radiation therapy alone, according to the results of the clinical trial, Radiation Therapy Oncology Group (RTOG) 9802 [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 1, 2016 Category: Databases & Libraries Source Type: news

Amazing Allison: A Young ‘Pioneer’ And The Boston Doctors Who Saved Her
BOSTON (CBS) – Just before Allison Schablein’s fifth birthday, she was diagnosed with brain cancer. Seven metastatic, malignant gliomas. Doctors could only remove one of them. Allison received chemotherapy. But it didn’t stop the cancer from growing. “She started with a terrible tumor in the worst circumstance,” says Dr. Mark Kieran, Director of Pediatric Neuro-Oncology at Dana Farber Cancer Institute. Fortunately, new technology allowed Dr. Kieran and the doctors at both Dana Farber and Boston Children’s Hospital to do a molecular profile of the single tumor they had removed. Incredibly, they discovered th...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - March 22, 2016 Category: Consumer Health News Authors: deanreddington Tags: Health Local News Seen On WBZ-TV Syndicated Local Watch Listen Allison Schablein Lisa Hughes Source Type: news

Father who thought he would be paralyzed walks daughter down the aisle at her wedding
Walter Thompson, a father from Oklahoma, was diagnosed with fist-sized, internal capsule glioma tumor in the middle of his brain just weeks before his daughter's wedding. (Source: the Mail online | Health)
Source: the Mail online | Health - March 17, 2016 Category: Consumer Health News Source Type: news

Cuba Has Made At Least 3 Major Medical Innovations That We Need
By most measures, the United States' business-friendly environment has proven to be fertile for medical innovation. Compared to other countries, America has filed the most patents in the life sciences, is conducting most of the world's clinical trials and has published the most biomedical research. That's what makes the medical prominence of Cuba all the more surprising to those who view a free market as an essential driver of scientific discovery. Cuba is very poor, and yet the country has some of the healthiest, most long-lived residents in the world -- as well as a medical invention or two that could run circl...
Source: Science - The Huffington Post - March 15, 2016 Category: Science Source Type: news

Next-generation immunotherapy offers new hope for beating brain cancer
(KU Leuven) High-grade glioma is the most aggressive form of brain cancer. Despite improvements in surgical procedures, chemotherapy, and radiotherapy, this type of brain tumor is still notoriously hard to treat: less than 10 percent of patients survive beyond five years. Researchers from KU Leuven, Belgium, have now shown that next-generation cell-based immunotherapy may offer new hope in the fight against brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 2, 2016 Category: Cancer & Oncology Source Type: news

FLAG Therapeutics Announces the Granting of Orphan Drug Designation to FLAG-003 in both the US and EU for the Treatment of Glioma
RALEIGH, N.C., March 1, 2016 -- (Healthcare Sales & Marketing Network) -- FLAG Therapeutics Inc. announced today that the U.S. Food and Drug Administration's Office of Orphan Products Development and the European Medicines Agency (EMA) have both granted O... Biopharmaceuticals, Oncology, FDA, RegulatoryFLAG Therapeutics, FLAG-003, glioma, glioblastoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 1, 2016 Category: Pharmaceuticals Source Type: news

Danish study finds increased glioma risk in a rosacea population
An increased focus on neurologic symptoms in patients with rosacea may be warranted, according to Danish researchers, who found a significantly increased risk of glioma associated with rosacea, in a nationwide study of Danish citizens. The observational study followed 5,484,910 Danish adults... (Source: Skin and Allergy News)
Source: Skin and Allergy News - February 9, 2016 Category: Dermatology Source Type: news

Rosacea May Be Associated With Development of GliomaRosacea May Be Associated With Development of Glioma
Danish researchers have linked the common facial skin disorder rosacea to the most frequent type of primary brain tumor in adults. Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - February 5, 2016 Category: Dermatology Tags: Dermatology News Source Type: news

Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
Stopping the growth of blood vessels in tumors is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. A team of researchers has developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 2, 2016 Category: Science Source Type: news

Scientists create imaging 'toolkit' to help identify new brain tumor drug targets
(eLife ) Stopping the growth of blood vessels in tumors is a key target for glioblastoma therapies, and imaging methods are essential for initial diagnosis and monitoring the effects of treatments. A team of researchers have developed a combined magnetic resonance imaging (MRI) and ultramicroscopy 'toolkit' to study vessel growth in glioma models in more detail than previously possible. Their study is to be published in the journal eLife. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 2, 2016 Category: Cancer & Oncology Source Type: news

Genetic cause identified in rare pediatric brain tumor
(Dana-Farber Cancer Institute) Researchers found a way of differentiating angiocentric gliomas from other low-grade pediatric brain tumors and developed a pathological test that will help children avoid unnecessary and potentially damaging additional therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 1, 2016 Category: Cancer & Oncology Source Type: news

New way to identify brain tumor aggressiveness
A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 28, 2016 Category: Science Source Type: news

In precision medicine, pioneering young patient teaches veteran doctor
Allison Schablein seems an unlikely candidate to teach medicine to Mark Kieran. She’s an 8-year-old New Hampshire second grader who loves basketball, hip hop, acrobatic dancing and jewelry. He’s a pediatric neuro-oncologist with a PhD in molecular biology, not to mention decades of clinical and research experience. But teach Kieran, Allison does. In December 2012, Allison was diagnosed with metastatic anaplastic astrocytoma brain tumors — two on her brain stem, two on her spine, and three at the top of her head. She had surgery and chemotherapy — and for two months her tumors responded to therapy. Then treatment st...
Source: Thrive, Children's Hospital Boston - January 28, 2016 Category: Pediatrics Authors: Irene Sege Tags: Diseases & Conditions Our Patients’ Stories Research Brain tumor Dana-Farber/Boston Children's Cancer and Blood Disorders Center glioma Mark Kieran precision medicine Source Type: news

Multi-center study reveals unique subtypes of most common malignant brain cancer
(University of Texas M. D. Anderson Cancer Center) An international collaborative study has revealed detailed new information about diffuse glioma, the most common type of tumor found in some 80 percent of adult brain cancer patients, raising hopes that better understanding of these disease groups may aid improved clinical outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

New way to identify brain tumor aggressiveness
(Columbia University Medical Center) A comprehensive analysis of the molecular characteristics of gliomas -- the most common malignant brain tumor -- explains why some patients diagnosed with slow-growing (low-grade) tumors quickly succumb to the disease while others with more aggressive (high-grade) tumors survive for many years. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

International study describes new glioma subtypes
(Fundação de Amparo à Pesquisa do Estado de São Paulo) In an international study conducted in Brazil, researchers have identified new glioma subtypes on the basis of epigenetic profile. The new findings serve to stratify glioma patients more accurately and will contribute to an enhancement of treatment protocols. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

New molecular profiling for glioma
(University of Sao Paulo Scientific Outreach Unit) Cell publishes on its Jan. 28th edition the results of the largest study ever performed on the molecular profiles of gliomas -- that represent 80 percent of tumors of the central nervous system. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: news

The Glioma International Case-Control StudyThe Glioma International Case-Control Study
The Glioma International Case-Control Study, currently underway, aims to evaluate both environmental exposures and genetic variation to advance our understanding of glioma etiology. American Journal of Epidemiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 27, 2016 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

[Editors' Choice] Hypoxia micromanages glioma
Hypoxia alters microRNA biogenesis in glioma cells to promote adaptation in the tumor microenvironment. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - January 20, 2016 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

Funding plea for treatment of brain tumour that no child has survived
No child has ever survived the rare brain tumour - diffuse intrinsic pontine glioma. But British doctors now have new hope in an innovative technique that delivers drugs directly to the tumour. (Source: the Mail online | Health)
Source: the Mail online | Health - January 10, 2016 Category: Consumer Health News Source Type: news

Hypnosis During Awake Surgery for Glioma Has Positive ImpactHypnosis During Awake Surgery for Glioma Has Positive Impact
In most patients undergoing awake surgery for low-grade glioma resection, hypnosis allows for the safe surgical removal of the tumor and has a positive psychologic impact. Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - January 8, 2016 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Hypnosis may provide new option for 'awake surgery' for brain cancer
(Wolters Kluwer Health) Could hypnosis help to reduce the psychological trauma associated with 'awake craniotomy' for brain cancers? A new 'hypnosedation' technique offers a new alternative for patients undergoing awake surgery for gliomas, suggests a study in the January issue of Neurosurgery, official journal of the Congress of Neurological Surgeons, published by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 28, 2015 Category: Global & Universal Source Type: news

Brain Cancers Reveal Novel Genetic Disruption in DNA
A study of gliomas found that DNA structure was disrupted, allowing separate segments to merge and activate a growth gene. An existing chemotherapy drug can fix that. (Source: NYT Health)
Source: NYT Health - December 23, 2015 Category: Consumer Health News Authors: GINA KOLATA Tags: Chemotherapy DNA (Deoxyribonucleic Acid) Brain Cancer Tumors Source Type: news

Follow-Up: Interview on the Beneficial Effects of Electrical Fields in Glioma Survival (FREE)
By the Editors Clinical Conversations interviews the first author of … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 22, 2015 Category: Primary Care Source Type: news

3D PET images show oxygen/CO2 transport in lungs
A 3D algorithm can utilize PET/CT images to map the movement of oxygen and...Read more on AuntMinnie.comRelated Reading: CT perfusion plus PET/CT aids lung cancer diagnosis Study questions PET efficacy with gliomas PET/CT helps predict lung cancer recurrence PET/CT helps speed lung cancer diagnosis Ultralow-dose lung MDCT may still find ground-glass lesions (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - December 21, 2015 Category: Radiology Source Type: news

'Smart fat cells' cross blood-brain barrier to catch early brain tumors
(Penn State) An MRI contrast agent that can pass through the blood-brain barrier will allow doctors to detect deadly brain tumors called gliomas earlier, say Penn State College of Medicine researchers. This ability opens the door to make this fatal cancer treatable. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 17, 2015 Category: Cancer & Oncology Source Type: news

Glioma Survival Increased by Use of Low-Intensity Electric Fields (FREE)
By Joe Elia Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Low-intensity alternating electric fields (AEF) applied to the scalp extend survival in glioblastoma, according to a JAMA study conducted by the equipment … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 16, 2015 Category: Primary Care Source Type: news

Brain cancer self-organizes into streams, swirls, and spheres
Brain cancer is not anarchy, say researchers but highly organized--self-organized. Researchers report that glioma cells build tumors by self-organizing into streams,10-20 cells wide, that obey a mathematically predicted pattern for autonomous agents flowing together. These streams drag along slower gliomas, may block entry of immune cells, and swirl around a central axis containing glioma stem cells that feed the tumor's growth. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 14, 2015 Category: Science Source Type: news

Brain cancer self-organizes into streams, swirls, and spheres
(American Society for Cell Biology) Brain cancer is not anarchy, say researchers but highly organized--self-organized. At ASCB 2015, they report that glioma cells build tumors by self-organizing into streams,10-20 cells wide, that obey a mathematically predicted pattern for autonomous agents flowing together. These streams drag along slower gliomas, may block entry of immune cells, and swirl around a central axis containing glioma stem cells that feed the tumor's growth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 14, 2015 Category: Cancer & Oncology Source Type: news

[Research Article] Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas
Secretion of pleiotrophin by aggressive gliomas triggers the formation of abnormal blood vessels by endothelial cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 9, 2015 Category: Science Authors: Lei Zhang, Soumi Kundu, Tjerk Feenstra, Xiujuan Li, Chuan Jin, Liisi Laaniste, Tamador Elsir Abu El Hassan, K. Elisabet Ohlin, Di Yu, Tommie Olofsson, Anna-Karin Olsson, Fredrik Pontén, Peetra U. Magnusson, Karin Forsberg Nilsson, Magnus Essand, Anja Smi Source Type: news

[Editors' Choice] Repurposing drugs for glioblastoma
Antidepressants plus anticoagulants trigger self-destruction in glioma cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 4, 2015 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

DIPG: Searching for a Cure
NEW YORK. (Ivanhoe Newswire) -- Diffuse intrinsic pontine glioma or DIPG, is an invasive pediatric brain cancer…a tumor in the brain stem that is impossible to safely remove. Radiation and traditional chemotherapy may buy a patient some time, but ultimately, can’t save a child’s life. Luckily, researchers are testing a new way to deliver cancer-fighting drugs that may someday soon lead to a cure. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 3, 2015 Category: Consumer Health News Source Type: news

Histone deacetylase 6 inhibition enhances oncolytic viral therapy
(Journal of Clinical Investigation) A new study in the Journal of Clinical Investigation indicates that inhibition of histone deaceteylase 6 improves the ability of oncolytic herpes simplex virus type 1 to kill glioma cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 20, 2015 Category: Cancer & Oncology Source Type: news

Major study finds 5 new genetic variants linked to brain cancer
(Institute of Cancer Research) The biggest ever study of DNA from people with glioma -- the most common form of brain cancer -- has discovered five new genetic variants associated with the disease. Researchers said their findings provided important new evidence for an inherited susceptibility to glioma, and offered potential clues for how to treat or prevent the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 1, 2015 Category: Cancer & Oncology Source Type: news

The Peptide Microarray-Based Resonance Light Scattering Assay for Sensitively Detecting Intracellular Kinase Activity
The peptide microarray technology is a robust, reliable, and efficient technique for large-scale determination of enzyme activities, and high-throughput profiling of substrate/inhibitor specificities of enzymes. Here, the activities of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) in different cell lysates have been detected by a peptide microarray-based resonance light scattering (RLS) assay with gold nanoparticle (GNP) probes. Highly sensitive detection of PKA activity in 0.1 μg total cell proteins of SHG-44 (human glioma cell) cell lysate (corresponding to 200 cells) is achieved by a selected...
Source: Springer protocols feed by Immunology - September 29, 2015 Category: Allergy & Immunology Source Type: news

Triphase gets Health Canada nod to begin Phase I trial of marizomib to treat glioma
Drug development firm Triphase Accelerator has received approval from Health Canada to begin its Phase I trial of marizomib in combination with bevacizumab (Avastin) to treat patients with recurrent malignant glioma in Canada. (Source: Drug Development Technology)
Source: Drug Development Technology - September 28, 2015 Category: Pharmaceuticals Source Type: news