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This page shows you the latest news and research items in this category.

Unsupervised Nosologic Imaging for Glioma Diagnosis
In this letter a novel approach to create nosologic images of the brain using magnetic resonance spectroscopic imaging (MRSI) data in an unsupervised way is presented. Different tissue patterns are identified from the MRSI data using nonnegative matrix factorization and are then coded as different primary colors (i.e. red, green, and blue) in an RGB image, so that mixed tissue regions are automatically visualized as mixtures of primary colors. The approach is useful in assisting glioma diagnosis, where several tissue patterns such as normal, tumor, and necrotic tissue can be present in the same voxel/spectrum. Error-maps b...
Source: IEEE Transactions on Biomedical Engineering - May 18, 2013 Category: Biomedical Engineering Source Type: research

In Preclinical Studies, New Drug Enhances Radiation Treatment For Brain Cancer
A novel drug may help increase the effectiveness of radiation therapy for the most deadly form of brain cancer, report scientists at Virginia Commonwealth University Massey Cancer Center. In mouse models of human glioblastoma multiforme (GBM), the new drug helped significantly extend survival when used in combination with radiation therapy. Recently published in the journal Clinical Cancer Research, the study provides the first preclinical evidence demonstrating that an ATM kinase inhibitor radiosensitizes gliomas... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Intraparenchymal Schwannoma Involving the Brainstem in a Young Woman
We report a 17-year-old girl with a 3-month history of unspecific dizziness, unsteadiness, and headache. Magnetic resonance imaging showed a heterogeneous cystic lesion involving midbrain, pons, and left cerebellar peduncle. The patient underwent a retromastoid craniotomy with complete resection of the tumor. Pathologic examination was compatible with intraparenchymal schwannoma. Since the first case of intraparenchymal schwannoma involving the brainstem was described in 1980, only seven others have been reported. Diagnosis of intraparenchymal schwannoma is almost never made preoperatively. Immunohistochemical staining is ...
Source: Pediatric Neurology - May 15, 2013 Category: Neurology Authors: Aida Antuña Ramos, Marco Antonio Alvarez Vega, Hernan Sandoval Valencia, Juan Campos García, Vicente Calatayud Perez Tags: Case Reports Source Type: research

Diagnostic Accuracy of PET for Recurrent Glioma Diagnosis: A Meta-Analysis [BRAIN]
CONCLUSIONS: 18F-FDG and 11C-MET PET appear to have moderately good accuracy as add-on tests for diagnosing recurrent glioma suspected by CT or MR imaging. Studies comparing alternative tracers or PET versus other imaging modalities are scarce. Prospective studies performing head-to-head comparisons between alternative imaging modalities are needed. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - May 15, 2013 Category: Radiology Authors: Nihashi, T., Dahabreh, I. J., Terasawa, T. Tags: BRAIN Source Type: research

Proteome-wide discovery of mislocated proteins in cancer [METHOD]
Several studies have sought systematically to identify protein subcellular locations, but an even larger task is to map which of these proteins conditionally relocate in disease (the mislocalizome). Here, we report an integrative computational framework for mapping conditional location and mislocation of proteins on a proteome-wide scale, called a conditional location predictor (CoLP). Using CoLP, we mapped the locations of over 10,000 proteins in normal human brain and in glioma. The prediction showed 0.9 accuracy using 100 location tests of 20 randomly selected proteins. Of the 10,000 proteins, over 150 have a strong lik...
Source: Genome Research - May 14, 2013 Category: Genetics & Stem Cells Authors: Lee, K., Byun, K., Hong, W., Chuang, H.-Y., Pack, C.-G., Bayarsaikhan, E., Paek, S. H., Kim, H., Shin, H. Y., Ideker, T., Lee, B. Tags: METHOD Source Type: research

Oncogenic MYBL1 rearrangements in pediatric glioma [Medical Sciences]
Pediatric low-grade gliomas (PLGGs) are among the most common solid tumors in children but, apart from BRAF kinase mutations or duplications in specific subclasses, few genetic driver events are known. Diffuse PLGGs comprise a set of uncommon subtypes that exhibit invasive growth and are therefore especially challenging clinically. We performed... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 14, 2013 Category: Science Authors: Ramkissoon, L. A., Horowitz, P. M., Craig, J. M., Ramkissoon, S. H., Rich, B. E., Schumacher, S. E., McKenna, A., Lawrence, M. S., Bergthold, G., Brastianos, P. K., Tabak, B., Ducar, M. D., Van Hummelen, P., MacConaill, L. E., Pouissant-Young, T., Cho, Y. Tags: Biological Sciences Source Type: research

Overexpressed miRNA-137 Inhibits Human Glioma Cells Growth by Targeting Rac1
Cancer Biotherapy & Radiopharmaceuticals May 2013, Vol. 28, No. 4: 327-334. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - May 13, 2013 Category: Cancer & Oncology Tags: article Source Type: research

Teaching NeuroImages: T2 hyperintensities in neurofibromatosis type 1
A 4-year-old boy with neurofibromatosis type 1 (NF1), an asymptomatic optic glioma, and a right basal ganglia T2-hyperintense lesion (figure, A and B) developed a left hemiparesis with hyperreflexia over the course of a year. Neuroimaging revealed a cyst-like mass in the region of his previously identified T2 hyperintensity (figure, C and D). While it is often difficult to distinguish T2 hyperintensities from low-grade glioma without tissue diagnosis,1 even with advanced imaging methods,2 T2 hyperintensities typically disappear with age and do not become cystic with associated mass effect. Coupled with the development of n...
Source: Neurology - May 13, 2013 Category: Neurology Authors: Ostendorf, A. P., McKinstry, R. C., Shimony, J. S., Gutmann, D. H. Tags: MRI, Primary brain tumor, All Pediatric, Developmental disorders, Neurofibromatosis RESIDENT AND FELLOW SECTION Source Type: research

In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis
Gaetano Gargiulo, Matteo Cesaroni, Michela Serresi, Nienke de Vries, Danielle Hulsman, Sophia W. Bruggeman, Cesare Lancini, Maarten van Lohuizen. In mouse and human neural progenitor and glioblastoma “stem-like” cells, we identified key targets of the Polycomb-group protein BMI1 by combining ChIP-seq with in vivo RNAi screening. We discover.... (Source: Cancer Cell)
Source: Cancer Cell - May 12, 2013 Category: Cancer & Oncology Source Type: research

HSP90 Inhibition in Olig2-Expressing Glioma Cells
In this study, we evaluated the effects of a novel HSP90 inhibitor, NVP-HSP990, in glioma tumor–initiating cell (GIC) populations, which are strongly implicated in the root pathobiology of GBM. In GIC cultures, NVP-HSP990 elicited a dose-dependent growth inhibition with IC50 values in the low nanomolar range. Two GIC subgroups with different responses were observed with an Olig2-expressing subset relatively more sensitive to treatment. We also showed that Olig2 is a functional marker associated with cell proliferation and response to NVP-HSP990, as NVP-HSP990 attenuated cell proliferation in Olig2-high GIC lines. In addi...
Source: Cancer Research - May 12, 2013 Category: Cancer & Oncology Authors: Fu, J., Koul, D., Yao, J., Wang, S., Yuan, Y., Colman, H., Sulman, E. P., Lang, F. F., Alfred Yung, W. K. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility
Conclusions: These results indicate for the first time that LIG4 rs1805388 and XRCC4 rs1805377, alone or in combination, are associated with a risk of gliomas. (Source: BMC Cancer)
Source: BMC Cancer - May 10, 2013 Category: Cancer & Oncology Authors: Peng ZhaoPeng ZouLin ZhaoWei YanChunsheng KangTao JiangYongping You Source Type: research

Chimeric antigen receptor containing ICOS signaling domain mediates specific and efficient antitumor effect of T cells against EGFRvIII expressing glioma
Conclusions: Our study demonstrates that the EGFRvIII/CAR-modified T cells can destroy glioma cells efficiently in an EGFRvIII specific manner and release IFN-gamma in an antigen dependent manner. The specific recognition and effective killing activity of the EGFRvIII-directed T cells with ICOS signaling domain lays a foundation for us to employ such approach in future cancer treatment. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 9, 2013 Category: Hematology Authors: Chan-Juan ShenYu-Xiu YangEthan HanNa CaoYun-Fei WangYi WangYing-Ying ZhaoLi-Ming ZhaoJian CuiPuja GuptaAlbert WongShuang-Yin Han Source Type: research

Cellular imaging and texture analysis distinguish differences in cellular dynamics in mouse brain tumors
ConclusionThe redistribution of a cellular label during tumor growth is characteristic of a tumor model. The label distribution map reflects more than simple differences in cell proliferation and is likely influenced by differences in the tumor microenvironment. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 9, 2013 Category: Radiology Authors: Lisa M. Gazdzinski, Brian J. Nieman Tags: Full Paper Source Type: research

APT‐weighted and NOE‐weighted image contrasts in glioma with different RF saturation powers based on magnetization transfer ratio asymmetry analyses
ConclusionThe APT and nuclear Overhauser enhancement image signals in tumor are maximized at different saturation powers. The saturation power of roughly 2 μT is ideal for APT‐weighted imaging at clinical B0 field strengths. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 9, 2013 Category: Radiology Authors: Jinyuan Zhou, Xiaohua Hong, Xuna Zhao, Jia‐Hong Gao, Jing Yuan Tags: Rapid Communication Source Type: research

BRAF V600E Mutation Identifies a Subset of Low-Grade Diffusely Infiltrating Gliomas in Adults [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - May 7, 2013 Category: Cancer & Oncology Authors: Chi, Batchelor, Yang, Dias-Santagata, Borger, Ellisen, Iafrate, Louis Tags: Brain Tumors, Diagnosis & Staging, Translational Oncology, Cancer Biomarkers, Neuro, Oncogenes DIAGNOSIS IN ONCOLOGY Source Type: research

Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion
Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion British Journal of Cancer advance online publication, May 7 2013. doi:10.1038/bjc.2013.218 Authors: M Nakada, E Nambu, N Furuyama, Y Yoshida, T Takino, Y Hayashi, H Sato, Y Sai, T Tsuji, K-i Miyamoto, A Hirao & J-i Hamada (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - May 7, 2013 Category: Cancer & Oncology Authors: M NakadaE NambuN FuruyamaY YoshidaT TakinoY HayashiH SatoY SaiT TsujiK-i MiyamotoA HiraoJ-i Hamada Source Type: research

Molecular definition of the pro‐tumorigenic phenotype of glioma‐activated microglia
Microglia are myeloid cells residing in the central nervous system that participate in inflammatory responses and could promote injury and repair. Gliomas attract microglia and polarize them into tumor‐supporting cells that participate in matrix remodeling, invasion, angiogenesis, and suppression of adaptive immunity. Although signaling pathways and critical regulators underlying classical inflammation are well established, signal transduction and transcriptional circuits underlying the alternative activation of microglia are poorly known. Using primary rat microglial cultures exposed to glioma conditioned medium or lipo...
Source: Glia - May 7, 2013 Category: Neurology Authors: Aleksandra Ellert‐Miklaszewska, Michal Dabrowski, Maciej Lipko, Marcin Sliwa, Marta Maleszewska, Bozena Kaminska Tags: Original Research Article Source Type: research

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression [Research Communications]
Recent studies have identified a Lys 27-to-methionine (K27M) mutation at one allele of H3F3A, one of the two genes encoding histone H3 variant H3.3, in 60% of high-grade pediatric glioma cases. The median survival of this group of patients after diagnosis is ~1 yr. Here we show that the levels of H3K27 di- and trimethylation (H3K27me2 and H3K27me3) are reduced globally in H3.3K27M patient samples due to the expression of the H3.3K27M mutant allele. Remarkably, we also observed that H3K27me3 and Ezh2 (the catalytic subunit of H3K27 methyltransferase) at chromatin are dramatically increased locally at hundreds of gene loci i...
Source: Genes and Development - May 7, 2013 Category: Genetics & Stem Cells Authors: Chan, K.-M., Fang, D., Gan, H., Hashizume, R., Yu, C., Schroeder, M., Gupta, N., Mueller, S., James, C. D., Jenkins, R., Sarkaria, J., Zhang, Z. Tags: Research Communications Source Type: research

Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth
Glioblastomas (GBMs) are very aggressive tumors that are resistant to conventional chemo- and radiotherapy. New molecular therapeutic strategies are required to effectively eliminate the subpopulation of GBM tumor–initiating cells that are responsible for relapse. Since EGFR is altered in 50% of GBMs, it represents one of the most promising targets; however, EGFR kinase inhibitors have produced poor results in clinical assays, with no clear explanation for the observed resistance. We uncovered a fundamental role for the dual-specificity tyrosine phosphorylation–regulated kinase, DYRK1A, in regulating EGFR in ...
Source: Journal of Clinical Investigation - May 3, 2013 Category: Biomedical Science Authors: Natividad Pozo, Cristina Zahonero, Paloma Fernández, Jose M. Liñares, Angel Ayuso, Masatoshi Hagiwara, Angel Pérez, Jose R. Ricoy, Aurelio Hernández-Laín, Juan M. Sepúlveda, Pilar Sánchez-Gómez Source Type: research

[Report] An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
A small molecule that inhibits a mutant enzyme in tumors slows malignant growth by inducing cancer cell differentiation. [Also see Perspective by Kim and DeBerardinis]Authors: Dan Rohle, Janeta Popovici-Muller, Nicolaos Palaskas, Sevin Turcan, Christian Grommes, Carl Campos, Jennifer Tsoi, Owen Clark, Barbara Oldrini, Evangelia Komisopoulou, Kaiko Kunii, Alicia Pedraza, Stefanie Schalm, Lee Silverman, Alexandra Miller, Fang Wang, Hua Yang, Yue Chen, Andrew Kernytsky, Marc K. Rosenblum, Wei Liu, Scott A. Biller, Shinsan M. Su, Cameron W. Brennan, Timothy A. Chan, Thomas G. Graeber, Katharine E. Yen, Ingo K. Mellinghoff (Sou...
Source: Science: Current Issue - May 3, 2013 Category: Science Authors: Dan Rohle Source Type: research

A scale-space method for detecting recurrent DNA copy number changes with analytical false discovery rate control
Tumor formation is partially driven by DNA copy number changes, which are typically measured using array comparative genomic hybridization, SNP arrays and DNA sequencing platforms. Many techniques are available for detecting recurring aberrations across multiple tumor samples, including CMAR, STAC, GISTIC and KC-SMART. GISTIC is widely used and detects both broad and focal (potentially overlapping) recurring events. However, GISTIC performs false discovery rate control on probes instead of events. Here we propose Analytical Multi-scale Identification of Recurrent Events, a multi-scale Gaussian smoothing approach, for the d...
Source: Nucleic Acids Research - May 3, 2013 Category: Research Authors: van Dyk, E., Reinders, M. J. T., Wessels, L. F. A. Tags: Computational Methods, Genomics Methods Online Source Type: research

Siglec‐h on activated microglia for recognition and engulfment of glioma cells
Sialic‐acid‐binding immunoglobulin‐like lectin‐h (Siglec‐h) is a recently identified mouse‐specific CD33‐related Siglec that signals via DAP12/TYROBP. Expression of Siglec‐h has been observed on plasmacytoid dendritic cells and microglia, but the ligand and the function of Siglec‐h remained elusive. Here, we demonstrate gene transcription and protein expression of Siglec‐h by mouse microglia after interferon‐γ treatment or polarization into a M1‐subtype. Microglial Siglec‐h acted as phagocytosis receptor since targeting of microsphere beads to Siglec‐h triggered their uptake into the microglia....
Source: Glia - May 1, 2013 Category: Neurology Authors: Jens Kopatz, Clara Beutner, Kristian Welle, Liviu G. Bodea, Julia Reinhardt, Janine Claude, Bettina Linnartz‐Gerlach, Harald Neumann Tags: Original Research Article Source Type: research

Intensity‐modulated radiotherapy (IMRT) in pediatric low‐grade glioma
CONCLUSIONSIMRT provided local control rates comparable to those provided by 2‐dimensional and 3‐dimensional radiotherapy. Margins ≥1 cm added to the GTV may not be necessary, because excellent local control was achieved by adding a 0.5‐cm margin (Method 2) and by dose painting (Method 3). Cancer 2013;. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - April 30, 2013 Category: Cancer & Oncology Authors: Arnold C. Paulino, Ali Mazloom, Keita Terashima, Jack Su, Adekunle M. Adesina, M. Faith Okcu, Bin S. Teh, Murali Chintagumpala Tags: Original Article Source Type: research

Phase 1/1b study of lonafarnib and temozolomide in patients with recurrent or temozolomide refractory glioblastoma
CONCLUSIONSThese results demonstrate that TMZ can be safely combined with a farnesyltransferase inhibitor and that this regimen is active, although the current study cannot determine the relative contributions of the 2 agents or the contribution of the novel administration schedule. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - April 30, 2013 Category: Cancer & Oncology Authors: Shlomit Yust‐Katz, Diane Liu, Ying Yuan, Vivien Liu, Sanghee Kang, Morris Groves, Vinay Puduvalli, Victor Levin, Charles Conrad, Howard Colman, Sigmonid Hsu, W. K. Alfred Yung, Mark R. Gilbert Tags: Original Article Source Type: research

Molecular subtypes of glioma identified by genome‐wide methylation profiling
Recent studies have indicated a prognostic role for genome‐wide methylation in gliomas: Tumors that show an overall increase in DNA methylation at CpG sites (CIMP+; CpG island methylator phenotype) have a more favorable prognosis than CIMP− gliomas. Here, we have determined whether methylation profiling can identify more and clinically relevant molecular subtypes of glioma by performing genome‐wide methylation profiling on 138 glial brain tumors of all histological diagnosis. Hopach (Hierarchical ordered partitioning and collapsing hybrid) clustering using the 1,000 most variable CpGs identified three distinct glioma...
Source: Genes, Chromosomes and Cancer - April 30, 2013 Category: Cancer & Oncology Authors: Nanne K. Kloosterhof, Johan J. Rooi, Max Kros, Paul H. C. Eilers, Peter A. E. Sillevis Smitt, Martin J. Bent, Pim J. French Tags: Research Article Source Type: research

Outcomes for temporal lobe epilepsy operations may not be equal: A call for an RCT of ATL vs SAH
An assured way to kindle a lively debate among epilepsy specialists is to ask, "What is the best surgery for medically refractory mesial temporal lobe epilepsy (mTLE)—anterior temporal lobectomy (ATL) or selective amygdalohippocampectomy (SAH)?" Usually, patients with mTLE have seizures arising from epileptogenic lesions such as hippocampal sclerosis or low-grade gliomas involving the lesion and surrounding hippocampus, amygdala, and parahippocampal cortex, although some mTLE cases do not have detectable lesions on imaging. ATL removes the temporal pole to allow access to the lesion and mesial temporal structures (fi...
Source: Neurology - April 29, 2013 Category: Neurology Authors: Mathern, G. W., Miller, J. W. Tags: Clinical trials Systematic review/meta analysis, All Epilepsy/Seizures, Epilepsy surgery, Hippocampal sclerosis EDITORIALS Source Type: research

A retrospective two-center study of antiepileptic prophylaxis in patients with surgically treated high-grade gliomas
Conclusions: We conclude that AEDs prophylaxis does not provide a substantial benefit to surgically treated high-grade glioma patients and should not be administered routinely. Further investigations are required to detect subgroups of patients at higher risk of developing seizures in order to selectively administer AED. (Source: Neurology India)
Source: Neurology India - April 29, 2013 Category: Neurology Authors: Diego GarbossaPier Paolo PancianiRomina AngeleriLuigi BattagliaFulvio TartaraMarco AjelloAlessandro AgnolettiPietro VersariAlessandro DucatiMarco FontanellaGiannantonio Spena Source Type: research

Cerebral syphilitic gumma misdiagnosed as glioma: A case report and literature review
Kun-liang Huo, Luo-tong Liu, Yang Ming, Huai-song Jing, Li-gang ChenNeurology India 2013 61(2):178-179 (Source: Neurology India)
Source: Neurology India - April 29, 2013 Category: Neurology Authors: Kun-liang HuoLuo-tong LiuYang MingHuai-song JingLi-gang Chen Source Type: research

Intracranial giant cell tumor of soft tissue: Mimicking a glioma
Sudhansu Sekhar Mishra, Satya Bhusan Senapati, Manmath Kumar Dhir, Kalpalata Tripathy, Deepak Kumar ParidaNeurology India 2013 61(2):192-193 (Source: Neurology India)
Source: Neurology India - April 29, 2013 Category: Neurology Authors: Sudhansu Sekhar MishraSatya Bhusan SenapatiManmath Kumar DhirKalpalata TripathyDeepak Kumar Parida Source Type: research

Inhibiting KDM1 expression slowed glioma growth
(Source: HemOncToday.com)
Source: HemOncToday.com - April 28, 2013 Category: Cancer & Oncology Source Type: news

Long‐term outcome of centrally located low‐grade glioma in children
CONCLUSIONSEffective and durable tumor control was obtained with RT as initial treatment. In younger patients, chemotherapy can delay the use of RT; however, frequent progression and long‐term morbidity are common. More effective and less toxic therapies are required in these patients, the majority of whom are long‐term survivors. Cancer 2013;. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - April 26, 2013 Category: Cancer & Oncology Authors: Keita Terashima, Kevin Chow, Jeremy Jones, Charlotte Ahern, Eunji Jo, Benjamin Ellezam, Arnold C. Paulino, M. Fatih Okcu, Jack Su, Adekunle Adesina, Anita Mahajan, Robert Dauser, William Whitehead, Ching Lau, Murali Chintagumpala Tags: Original Article Source Type: research

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma
Conclusions: In summary, we demonstrated that EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas. (Source: Molecular Cancer)
Source: Molecular Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Yasufumi KatanasakaYasuo KoderaYuka KitamuraTatsuya MorimotoTomohide TamuraFumiaki Koizumi Source Type: research

Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival
Sox11 expression in astrocytic gliomas: correlation with nestin/c-Met/IDH1-R132H expression phenotypes, p-Stat-3 and survival British Journal of Cancer advance online publication, April 25 2013. doi:10.1038/bjc.2013.176 Authors: P Korkolopoulou, G Levidou, E A El-Habr, C Adamopoulos, P Fragkou, E Boviatsis, M S Themistocleous, K Petraki, G Vrettakos, M Sakalidou, V Samaras, A Zisakis, A Saetta, I Chatziandreou, E Patsouris & C Piperi (Source: British Journal of Cancer AOP)
Source: British Journal of Cancer AOP - April 25, 2013 Category: Cancer & Oncology Authors: P KorkolopoulouG LevidouE A El-HabrC AdamopoulosP FragkouE BoviatsisM S ThemistocleousK PetrakiG VrettakosM SakalidouV SamarasA ZisakisA SaettaI ChatziandreouE PatsourisC Piperi Source Type: research

Effect of Bluetooth headset and mobile phone electromagnetic fields on the human auditory nerve
ConclusionsThe outcomes of the present study show that, contrary to the finding that the latency and amplitude of CNAPs are very sensitive to EMFs produced by the tested mobile phone, the EMFs produced by a common Bluetooth device do not induce any significant change in cochlear nerve activity. The conditions of exposure, therefore, differ from those of everyday life, in which various biological tissues may reduce the EMF affecting the cochlear nerve. Nevertheless, these novel findings may have important safety implications. Level of Evidence4. Laryngoscope, 2013 (Source: The Laryngoscope)
Source: The Laryngoscope - April 25, 2013 Category: ENT & OMF Authors: Marco Mandalà, Vittorio Colletti, Luca Sacchetto, Paolo Manganotti, Stefano Ramat, Alessandro Marcocci, Liliana Colletti Tags: Otology/Neurotology Source Type: research

Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells
In conclusion our findings contribute to an unbiased identification of cancer stem-like cells and stromal cells in brain neoplasms, and provide novel insight into the complex issue of drug delivery to the brain. Since efflux properties of endothelial cells are likely to compromise drug availability, transiently targeting ATP-binding cassette transporters may be a valuable therapeutic strategy to improve treatment effects in brain tumours. (Source: Brain)
Source: Brain - April 24, 2013 Category: Neurology Authors: Golebiewska, A., Bougnaud, S., Stieber, D., Brons, N. H. C., Vallar, L., Hertel, F., Klink, B., Schrock, E., Bjerkvig, R., Niclou, S. P. Tags: Original Articles Source Type: research

Limited plastic potential of the left ventral premotor cortex in speech articulation: Evidence From intraoperative awake mapping in glioma patients
Conclusions: Our original data suggest that the vPMC plays a crucial role in the speech production network and that its plastic potential is limited. We propose that this limitation is due to an anatomical constraint, namely the necessity for the left vPMC to remain connected to the lateral SLF. Beyond fundamental implications, such knowledge may have clinical applications, especially in surgery for tumors involving this cortico‐subcortical circuit. Hum Brain Mapp, 2013. © 2013 Wiley Periodicals, Inc. (Source: Human Brain Mapping)
Source: Human Brain Mapping - April 24, 2013 Category: Neurology Authors: Kim van Geemen, Guillaume Herbet, Sylvie Moritz‐Gasser, Hugues Duffau Tags: Research Article Source Type: research

Modeling risk stratification in human cancer
Conclusion: In constraining between-group significances, the risk score compares favorably with previous risk classifications. Availability: Risk assessment is freely available on the Web at https://gliserv.montp.inserm.fr/PrognoWeb/ for personal or test data files. Web site implementation in Perl, R and Apache. Contact: thierry.reme@inserm.fr Supplementary information: Supplementary data are available at Bioinformatics online. (Source: Bioinformatics)
Source: Bioinformatics - April 23, 2013 Category: Bioinformatics Authors: Reme, T., Hose, D., Theillet, C., Klein, B. Tags: GENE EXPRESSION Source Type: research

Teaching NeuroImages: Basal ganglia involvement in facio-brachial dystonic seizures associated with LGI1 antibodies
A 30-year-old man developed right facio-brachial dystonic seizures (FBDS).1 Ictal and interictal EEGs were normal. CSF analysis was unremarkable. Brain MRI revealed a gadolinium-enhancing lesion involving the left caudate and globus pallidus (figure 1). Leucine-rich glioma inactivated protein-1 (LGI-1) antibodies were detected in the serum. Total-body CT scan revealed no malignancies. The patient underwent 5 cycles of plasmapheresis followed by long-term steroid therapy with complete benefit. A brain MRI performed after 5 months showed reduction of contrast enhancement (figure 2). LGI-1, a secreted protein complexed with v...
Source: Neurology - April 22, 2013 Category: Neurology Authors: Plantone, D., Renna, R., Grossi, D., Plantone, F., Iorio, R. Tags: MRI, All Immunology, Autoimmune diseases RESIDENT AND FELLOW SECTION Source Type: research

Therapeutic concentrations of anti‐epileptic drugs do not inhibit the activity of the oncolytic adenovirus Delta24‐RGD in malignant glioma
ConclusionsTherapeutic levels of valproic acid, phenytoin and levetiracetam do not negatively interfere with the infection efficiency or oncolytic activity of Delta24‐RGD in patient‐derived GBM cells. Therefore, there is no indication that the choice of anticonvulsant for seizure control in glioma patients should take treatment with Delta24‐RGD into account. Copyright © 2013 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - April 22, 2013 Category: Genetics & Stem Cells Authors: Jonas Jonge, Lotte M. E. Berghauser Pont, Sander Idema, Jenneke J. Kloezeman, David Noske, Clemens M. F. Dirven, Martine L. M. Lamfers Tags: Research Article Source Type: research

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3
This study establishes a link between PCBP2 and FHL3 proteins and identifies a new pathway for regulating glioma progression. (Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - April 19, 2013 Category: Biomedical Science Authors: Wei Han, Zhongshuai Xin, Zhiqiang Zhao, Wen Bao, Xihua Lin, Bin Yin, Jizong Zhao, Jiangang Yuan, Boqin Qiang, Xiaozhong Peng Source Type: research

Virus-like particles provide vital clues about brain tumors
(Lund University) Exosomes are small, virus-like particles that can transport genetic material and signal substances between cells. Researchers at Lund University, Sweden, have made new findings about exosomes released from aggressive brain tumors, gliomas. These exosomes are shown to have an important function in brain tumor development, and could be utilized as biomarkers to assess tumor aggressiveness through a blood test. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 17, 2013 Category: Cancer & Oncology Source Type: news

MicroRNA-495 inhibits proliferation of glioblastoma multiforme cells by downregulating cyclin-dependent kinase 6
Conclusions: This study revealed miR-495 is down-regulated in glioma tissues. Furthermore, miR-495 regulated CDK6 expression and involved in glioma cell growth inhibition, which indicated the possible role of miR-495 in tumor progression. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - April 17, 2013 Category: Cancer & Oncology Authors: Shu-Mei ChenHua-Chien ChenShu-Jen ChenChiung-Yin HuangPin-Yuan ChenTai-Wei WuLy-Ying FengHong-Chieh TsaiTai-Ngar LuiChuen HsuehKuo-Chen Wei Source Type: research

BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas
Background: The bone morphogenetic family proteins (BMP) are phytogenetically conserved proteins, which are essential for embryonic development. The key regulatory subunit, the bone morphogenetic protein 4 (BMP4), is overexpressed and associated with tumor metastasis in a variety of cancers. However, the prognostic and molecular features of gliomas with BMP4 expression is still unclear. Methods: We obtained whole genome mRNA expression microarray data of 220 glioma samples of all grades from Chinese Glioma Genome Atlas (CGGA) database (http://www.cgga.org.cn) as discovery set. Of the 123 high-grade gliomas in this set, 33 ...
Source: Journal of Translational Medicine - April 16, 2013 Category: Research Authors: Zhaoshi BaoChuanbao ZhangWei YanYanwei LiuMingyang LiWei ZhangTao Jiang Source Type: research

Optimizing p53-based therapy in gliomas [Medical Sciences]
Based on clinical presentation, glioblastoma (GBM) is stratified into primary and secondary types. The protein 53 (p53) pathway is functionally incapacitated in most GBMs by distinctive type-specific mechanisms. To model human gliomagenesis, we used a GFAP-HRasV12 mouse model crossed into the p53ERTAM background, such that either one or both copies... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 16, 2013 Category: Science Authors: Shchors, K., Persson, A. I., Rostker, F., Tihan, T., Lyubynska, N., Li, N., Swigart, L. B., Berger, M. S., Hanahan, D., Weiss, W. A., Evan, G. I. Tags: PNAS Plus Source Type: research

A comparative study of short‐ and long‐TE 1H MRS at 3 T for in vivo detection of 2‐hydroxyglutarate in brain tumors
We report a comparative study of the utility of short‐ and long‐TE point‐resolved spectroscopy (PRESS) for the detection of the oncometabolite 2‐hydroxyglutarate (2HG) at 3 T. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with isocitrate dehydrogenase (IDH)‐mutated gliomas. The results indicate that TE = 97 ms provides a higher selectivity of 2HG signals than at short TEs, and that this improved capability is gained when appropriate basis spectra are used for spectral fitting. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - April 16, 2013 Category: Radiology Authors: Changho Choi, Sandeep Ganji, Keith Hulsey, Akshay Madan, Zoltan Kovacs, Ivan Dimitrov, Song Zhang, Kumar Pichumani, Dianne Mendelsohn, Bruce Mickey, Craig Malloy, Robert Bachoo, Ralph DeBerardinis, Elizabeth Maher Tags: Research article Source Type: research

Advances In Understanding Of Genetic Defects Underlying Childhood Low-Grade Gliomas
The St. Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project has identified mutations responsible for more than half of a subtype of childhood brain tumor that takes a high toll on patients. Researchers also found evidence the tumors are susceptible to drugs already in development. The study focused on a family of brain tumors known as low-grade gliomas (LGGs). These slow-growing cancers are found in about 700 children annually in the U.S., making them the most common childhood tumors of the brain and spinal cord... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 15, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

A Distinct Reactive Oxygen Species Profile Confers Chemoresistance in Glioma-Propagating Cells and Associates with Patient Survival Outcome
Antioxidants & Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - April 12, 2013 Category: Research Tags: article Source Type: research

Inhibitory Effect of Neuropilin-1 Monoclonal Antibody (NRP-1 MAb) on Glioma Tumor in Mice
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 12, 2013 Category: Nanotechnology Authors: Chen, LukuiMiao, WeiTang, XiaoyongZhang, HaipengWang, ShengyuLuo, FanghongYan, Jianghua Tags: Articles Source Type: research

The Expression and Significance of Neuropilin-1 (NRP-1) on Glioma Cell Lines and Glioma Tissues
(Source: Journal of Biomedical Nanotechnology)
Source: Journal of Biomedical Nanotechnology - April 12, 2013 Category: Nanotechnology Authors: Chen, LukuiMiao, WeiTang, XiaoyongZhang, HaipengWang, ShengyuLuo, FanghongYan, Jianghua Tags: Review Source Type: research

INTEROCC case--control study: lack of association between glioma tumors and occupational exposure to selected combustion products, dusts and other chemical agents
Conclusion: Thus, there was no evidence that these exposures influence risk of glioma. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - April 12, 2013 Category: Consumer Health News Authors: Aude LacourtElisabeth CardisJavier PintosLesley RichardsonLaurel KinclGeza BenkeSarah FlemingMartine HoursDaniel KrewskiDave McLeanMarie-Elise ParentSiegal SadetzkiKlaus SchlaeferBrigitte SchlehoferMartie van TongerenJack Siemiatycki Source Type: research