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Impact of TGF-β1  -509C/T and 869T/C polymorphisms on glioma risk and patient prognosis
In conclusion, this study suggests that TGF-β1 -509C/T and 869T/C polymorphisms are not significantly associated with risk for developing gliomas but may be relevant prognostic biomarkers in GBM patients. (Source: Tumor Biology)
Source: Tumor Biology - March 27, 2015 Category: Cancer & Oncology Source Type: research

MicroRNA-184 inhibits cell proliferation and invasion, and specifically targets TNFAIP2 in Glioma
Conclusions: miR-184 could regulate TNFAIP2 expression and affected its translation in glioma. miR-184 could also inhibit glioma progression and might serve as a novel therapeutic target in glioma. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - March 26, 2015 Category: Cancer & Oncology Authors: Zhe ChengHang WangXuetao LiZhiwu WuYong HanYanyan LiGuilin ChenXueshun XieYulun HuangZiwei DuYouxin Zhou Source Type: research

Comprehensive analysis of microRNA expression profile in malignant glioma tissues
Malignant gliomas represent the most devastating group of brain tumors in adults, among which glioblastoma multiforme (GBM) exhibits the highest malignancy rate. Despite combined modality treatment, GBM recurs and is invariably fatal. A further insight into the molecular background of gliomagenesis is required to improve patient outcomes. The primary aim of this study was to gain broad information on the miRNA expression pattern in malignant gliomas, mainly GBM. We investigated the global miRNA profile of malignant glioma tissues with miRNA microarrays, deep sequencing and meta-analysis. (Source: Molecular Oncology)
Source: Molecular Oncology - March 26, 2015 Category: Cancer & Oncology Authors: Monika Piwecka, Katarzyna Rolle, Agnieszka Belter, Anna Maria Barciszewska, Marek Żywicki, Marcin Michalak, Stanisław Nowak, Mirosława Z. Naskręt-Barciszewska, Jan Barciszewski Source Type: research

Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature
Conclusions We conclude that 1. KD is safe and without major side effects; 2. ketosis can be induced using customary foods; 3. treatment with KD may be effective in controlling the progression of some gliomas; and 4. further studies are needed to determine factors that influence the effectiveness of KD, whether as a monotherapy, or as adjunctive or supplemental therapy in treating glioma patients. Trial registration ClinicalTrials.gov# NCT01535911 (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - March 25, 2015 Category: Cancer & Oncology Source Type: research

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain
Chordoid glioma of the third ventricle is a rare neuroepithelial tumor characterized by a unique histomorphology and exclusive association with the suprasellar/third ventricular compartment. Variously interpreted as either astrocytic- or ependymal-like, and speculatively ascribed to the lamina terminalis/subcommissural organ, its histogenesis remains, nevertheless, unsettled. Here, we report on a suprasellar chordoid glioma occurring in a 52-year-old male. While displaying otherwise typical morphological features, the tumor was notable for expression of thyroid transcription factor 1, a marker of tumors of pituicytic origi...
Source: Human Pathology - March 25, 2015 Category: Pathology Authors: Ekkehard Hewer, Jürgen Beck, Frauke Kellner-Weldon, Istvan Vajta Tags: Case Report Source Type: research

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences.
In this report on 303 gliomas we show the highest frequency of TERT promoter mutations in gliobastomas (80%) followed by oligodendrogliomas (70%) and astrocytomas (39%). We observed positive association between TERT promoter and IDH mutations in oligodendroglial tumors (OR = 26.3; 95% CI 2.5-250.2) and inverse association in primary glioblastomas (OR = 0.13; 95% CI 0.03-0.58). Tumors with TERT promoter mutations compared to those without showed increased TERT transcription; we also showed difference in the transcription levels due to the two main mutations. Tumors with TERT promoter mutations had shorter telomeres than tho...
Source: Oncotarget - March 24, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Direct Solvent‐Derived Polymer‐Coated Nitrogen‐Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma
Cancer imaging requires biocompatible and bright contrast‐agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1‐methyl‐2‐pyrrolidinone (NMP)‐derived polymer‐coated nitrogen‐doped carbon nanodots (pN‐CNDs) with a particle size in the range of 5–15 nm are prepared by a facile direct solvothermal reaction. The as‐prepared pN‐CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK‐8) and histology analysis both demonstrate that the pN‐CNDs have no obvious cytotoxicity. Most importantly, ...
Source: Small - March 24, 2015 Category: Nanotechnology Authors: Yi Wang, Ying Meng, Shanshan Wang, Chengyi Li, Wei Shi, Jian Chen, Jianxin Wang, Rongqin Huang Tags: Full Paper Source Type: research

Concise Review: Bullseye: Targeting Cancer Stem Cells to Improve the Treatment of Gliomas by Repurposing Disulfiram
Abstract Cancer stem cells (CSCs) are thought to be at the root of cancer recurrence because they resist conventional therapies and subsequently reinitiate tumor cell growth. Thus, targeting CSCs could be the bullseye to successful cancer therapeutics in the future. Brain tumors are some of the most challenging types of cancer to treat and the median survival following the initial diagnosis is 12–18 months. Among the different types of brain tumors, glioblastoma (GBM) is considered the most aggressive and remains extremely difficult to treat. Despite surgery, radiation, and chemotherapy, most patients develop refractory ...
Source: Stem Cells - March 24, 2015 Category: Stem Cells Authors: Joanna Triscott, Mary Rose Pambid, Sandra E. Dunn Tags: Cancer Stem Cells Source Type: research

CRNDE, a long-non coding RNA, promotes glioma cell growth and invasion through mTOR signaling
• We identified a highly expressed lncRNA, the Colorectal Neoplasia Differentially Expressed (CRNDE) as an oncogene for its function in promoting cell growth and migration in human gliomas by in vitro and in vivo studies.• We found histone acetylation in the promoter region accounts for regulation of CRNDE gene expression, and the CRNDE modulates mammalian Target of Rapamycin (mTOR) signaling in glioma.• Our findings suggest CRNDE as a diagnostic marker for glioma or a potential therapeutic target for the treatment of glioma. (Source: Cancer Letters)
Source: Cancer Letters - March 24, 2015 Category: Cancer & Oncology Authors: Yunliang Wang, Yutong Wang, Jinfeng Li, Yuzhen Zhang, Honglei Yin, Bing Han Tags: Original Articles Source Type: research

CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling
Glioma is the most common and aggressive primary tumor in the nervous system, and accounts for about 80% of primary malignant brain tumors [1,2]. Gliomas are rarely curable. This is especially true for glioblastoma, which is the most aggressive malignant type of glioma. Without treatment, the average life expectancy for glioblastoma patients is only 4.5 months. With temozolomide (TMZ) treatment, the life expectancy of the patients is extended to about 15 months [3]. The moderate response rate from the glioma patients to TMZ-based chemotherapy is largely due to the occurrence of chemoresistance [4]. (Source: Cancer Letters)
Source: Cancer Letters - March 24, 2015 Category: Cancer & Oncology Authors: Yunliang Wang, Yutong Wang, Jinfeng Li, Yuzhen Zhang, Honglei Yin, Bing Han Tags: Original Articles Source Type: research

Hormonal contraceptive use and risk of glioma among younger women: a nationwide case–control study
ConclusionLong term hormonal contraceptive use may increase the risk of glioma. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - March 23, 2015 Category: Drugs & Pharmacology Authors: Lene Andersen, Søren Friis, Jesper Hallas, Pernille Ravn, Bjarne W. Kristensen, David Gaist Tags: Pharmacoepidemiology Source Type: research

Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma
Glioblastoma multiforme (GBM) is the most aggressive and malignant brain tumor. Delicate microenvironment and lineage heterogeneity of GBM cells including infiltration, hypoxia, angiogenesis, and stemness make them highly resistant to current conventional therapies, with an average life expectancy for GBM patients of less than 15 months. Poor response to cytotoxic agents of GBM cells remains the major challenge of GBM treatment. Resistance of GBM to clinical treatment is a result of genomic alternation and deregulated signaling pathways, such as p53 mutation and apoptosis signaling blockage, providing cancer cells more opp...
Source: Experimental Biology and Medicine - March 23, 2015 Category: Research Authors: Liu, S.-Y., Chiang, M.-F., Chen, Y.-J. Tags: WWOX in Cancer Source Type: research

Biopsy of Brainstem Gliomas Using Flexible Endoscopes
Conclusion The use of flexible endoscops for biopsy of ventral, dorsal (tectum lamina quadrigemina), and diffuse brainstem tumors is a useful, effective, and safe procedure that also allows to treat obstructive hydrocephalus secondary to the tumors.[...]Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - March 23, 2015 Category: Neurosurgery Authors: Torres Corzo, Jaime GerardoRodriguez, Jose SanchezCastillo, Juan LucinoEscobedo, Reynaldo FalconCervantes, DominicDella Vecchia, Roberto RodriguezVinas Rios, Juan Manuel Tags: Original Article Source Type: research

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion
Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion Oncogene advance online publication, March 23 2015. doi:10.1038/onc.2015.60 Authors: L Sleire, B S Skeie, I A Netland, H E Førde, E Dodoo, F Selheim, L Leiss, J I Heggdal, P-H Pedersen, J Wang & P Ø Enger (Source: Oncogene)
Source: Oncogene - March 23, 2015 Category: Cancer & Oncology Authors: L SleireB S SkeieI A NetlandH E FørdeE DodooF SelheimL LeissJ I HeggdalP-H PedersenJ WangP Ø Enger Source Type: research

Serine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma.
Abstract Glioma is the most common type of primary central nervous system tumor. Ser/Thr protein phosphatase 5 (PP5) has been shown to regulate multiple signaling cascades that suppress growth and facilitate apoptosis in several human cancer cells. However, the role of PP5 in human gliomas remains unclear. Herein, the relationship between PP5 expression and glioma cell growth was investigated, and the therapeutic value of PP5 in glioma was further evaluated. We employed a short hairpin RNA targeting PPP5C gene to knock down PP5 expression in human glioma cell lines U251 and U373. Depletion of PPP5C via RNAi remarka...
Source: Cellular and Molecular Neurobiology - March 22, 2015 Category: Cytology Authors: Zhi X, Zhang H, He C, Wei Y, Bian L, Li G Tags: Cell Mol Neurobiol Source Type: research

Bevacizumab in high-grade gliomas: past, present, and future
Expert Review of Anticancer Therapy, Volume 15, Issue 4, Page 387-397, April 2015. (Source: Expert Review of Anticancer Therapy)
Source: Expert Review of Anticancer Therapy - March 21, 2015 Category: Cancer & Oncology Tags: article Source Type: research

Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression
In this study, 5–30μM of oridonin, a natural diterpenoid compound isolated from the traditional Chinese medicine, Rabdosia rubescens, induced U87MG glioma cell apoptosis and RNA accumulation in nucleus at 12h-time point. Before U87MG cell apoptosis, the RanGAP1 protein amount decreased and RanGTP accumulated in nucleus as respectively determined by immunoprecipitation and immunofluorescence, suggesting that decrease of RanGAP1 may result in nuclear entrapment of RanGTP and RNA, and then induce U87MG cell death. In contrast, over-expression of the RanGAP1 protein reversed oridonin-induced U87MG cell apoptosis. Hence, we ...
Source: Chemico Biological Interactions - March 21, 2015 Category: Biochemistry Source Type: research

Glioma grading by microvascular permeability parameters derived from dynamic contrast-enhanced MRI and intratumoral susceptibility signal on susceptibility weighted imaging
This study assessed volume transfer constant (Ktrans) accuracy, the volume of extravascular extracellular space (EES) per unit volume of tissue (Ve) derived from DCE-MRI, and the degree of ITSS in glioma grading. Methods: Thirty-two patients with different glioma grades were enrolled in this retrospective study. Patients underwent DCE-MRI and non-contrast enhanced SWI by three-tesla scanning. Ktrans values, Ve, and the degree of ITSS in glioma were compared. Receiver operating characteristic (ROC) curve analysis determined diagnostic performances of Ktrans and Ve in glioma grading, and Spearman’s correlation analysis det...
Source: Cancer Imaging - March 21, 2015 Category: Radiology Authors: Xiaoguang LiYongshan ZhuHouyi KangYulong ZhangHuaping LiangSumei WangWeiguo Zhang Source Type: research

Histopathological findings in the peritumoral edema area of human glioma.
Authors: Wang X, Liu X, Chen Y, Lin G, Mei W, Chen J, Liu Y, Lin Z, Zhang S Abstract Peritumoral brain edema (PTBE) is considered to be one of the main biological behaviors of brain glioma. However, the histopathological features of PTBE remain imprecisely defined. We analyzed the histopathological characteristics in the PTBE area of 22 cases of glioma. Microscopically, the pre-existing basic structure in the edema area was still preserved but there were varying degrees of loose tissue. The main components of the edema tissue were scattered invasive tumor cells, reactive cells, and various blood vessel patterns. In...
Source: Histology and Histopathology - March 20, 2015 Category: Cytology Tags: Histol Histopathol Source Type: research

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.
In this study, we report an effective strategy for cancer therapy through targeting glucose transporter 3 (GLUT3) with siRNA-based nanomedicine to simultaneously inhibit the self-renewal of glioma stem cells and bulk glioma cells in a glucose restricted tumor micro-environment. We have demonstrated that cationic lipid-assisted poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PLA) nanoparticles can efficiently deliver siRNA into U87MG and U251 glioma stem cells and bulk glioma cells. Nanoparticles carrying specific siRNA targeting GLUT3 (NPsiGLUT3) were able to significantly reduce the expression of GLUT3 in glioma stem cells...
Source: Biomaterials - March 20, 2015 Category: Materials Science Authors: Xu CF, Liu Y, Shen S, Zhu YH, Wang J Tags: Biomaterials Source Type: research

Imaging of Important Causes of Brain Stem Enlargement: Beyond the Low-Grade Glioma
The brain stem is a critical part of the central nervous system (CNS); it houses the cranial nerve nuclei and cardiopulmonary centers, and serves as a conduit for descending tracts into the spinal cord. The brain stem is located in the posterior fossa, and anatomically is composed of the midbrain (most rostral part of the brain stem), pons, and medulla. Gliomas are the most common cause of brain stem enlargement. However, a variety of other pathologic processes such as infection, metastasis, inflammation or demyelination, hemorrhagic lesions, posterior reversible encephalopathy syndrome, and hypertrophic olivary degenerati...
Source: Contemporary Diagnostic Radiology - March 20, 2015 Category: Radiology Tags: Article Source Type: research

Imaging of Important Causes of Brain Stem Enlargement: Beyond the Low-Grade Glioma
No abstract available (Source: Contemporary Diagnostic Radiology)
Source: Contemporary Diagnostic Radiology - March 20, 2015 Category: Radiology Tags: CME Quiz: Volume 38, Number 8 Source Type: research

Pilocytic astrocytoma: pathology, molecular mechanisms and markers
Abstract Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago. They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over 90 %. Many require merely surgical removal and only very infrequently do they progress to more malignant gliomas. While most show classical morphology, they may present a spectrum of morphological patterns, and there are difficult cases that show similarities to other gliomas, some of which are malignant and require aggressive treatment. Until recently, almost nothing was known about the molecular mechanisms involved in th...
Source: Acta Neuropathologica - March 20, 2015 Category: Neurology Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

O5.2 * The Development of CDK4 Inhibitors for Cancer Therapy
In this study Palbociclib (Palbo) improved median progression free survival (mPFS) from 10.2 months with letrozole alone to 20.2 months with Palbo in the combination therapy [Hazard Ratio (HR) 0.488 (95% CI 0.319, 0.748)]. Response rates were 55.4% with the combination and 39.4% with letrozole alone. Palbo has been tested in other disease including dedifferentiated and well-differentiated liposarcoma where CDK4 is amplified. In this disease Palbo has been reported to increase the PFS at 12 weeks to 66% surpassing the primary end of 40% in patients who had progressed on at least one primary regimen. The major toxicity is ne...
Source: Annals of Oncology - March 20, 2015 Category: Cancer & Oncology Authors: Schwartz, G. Tags: Plenary session 5: CDK-targeting agents Source Type: research

Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case–control study
Conclusions High folate intake during childhood may reduce the risk of CBT. This potentially important finding needs to be corroborated in other studies. If replicated, these results could have important implications for public health recommendations regarding diet during childhood. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - March 19, 2015 Category: Cancer & Oncology Source Type: research

Letter: Reoperation for Recurrent High-Grade Glioma: Does Tumor Genetics Play a Role?
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - March 19, 2015 Category: Neurosurgery Tags: Correspondence Source Type: research

In Reply: Reoperation for Recurrent High-Grade Glioma: Does Tumor Genetics Play a Role?
No abstract available (Source: Neurosurgery)
Source: Neurosurgery - March 19, 2015 Category: Neurosurgery Tags: Correspondence Source Type: research

Initial Experience Using Awake Surgery for Glioma: Oncological, Functional, and Employment Outcomes in a Consecutive Series of 25 Cases
CONCLUSION: These oncological and functional results of awake glioma surgery during the learning curve are comparable to results from established centers. The use and utility of resection probability maps are well demonstrated. The return to work level is high. ABBREVIATION: FLAIR, fluid-attenuated inversion-recovery (Source: Neurosurgery)
Source: Neurosurgery - March 19, 2015 Category: Neurosurgery Tags: Research-Human-Clinical Studies Source Type: research

Dedifferentiation of patient‐derived glioblastoma multiforme cell lines results in a cancer stem cell‐like state with mitogen‐independent growth
Abstract Emerging evidence shows that glioblastoma multiforme (GBM) originates from cancer stem cells (CSCs). Characterization of CSC‐specific signalling pathways would help identify new therapeutic targets and perhaps lead to the development of more efficient therapies selectively targeting CSCs. Here; we successfully dedifferentiated two patient‐derived GBM cell lines into CSC‐like cells (induced glioma stem cells, iGSCs) through expression of Oct4, Sox2 and Nanog transcription factors. Transformed cells exhibited significant suppression of epidermal growth factor receptor and its downstream pathways. Compared with...
Source: Journal of Cellular and Molecular Medicine - March 19, 2015 Category: Molecular Biology Authors: Inan Olmez, Wangzhen Shen, Hayes McDonald, Bulent Ozpolat Tags: Original Article Source Type: research

Mechanisms regulating glioma invasion
• Glioblastoma (GBM) is the deadliest and most common brain malignancy in adults with a dismal median survival of about 14 months.• Because of its tendency to aggressively invade throughout the brain, surgical resection and localized radiotherapy cannot completely target all malignant GBM cells.• GBM invasion can be regulated by the PI3K/Akt, Wnt, sonic hedgehog-GLI1, and microRNAs. (Source: Cancer Letters)
Source: Cancer Letters - March 19, 2015 Category: Cancer & Oncology Authors: Ivy Paw, Richard C. Carpenter, Kounosuke Watabe, Waldemar Debinski, Hui-Wen Lo Tags: Mini-review Source Type: research

[Chemotherapy of brain tumors in aduts].
Abstract The treatment of patients with brain tumors has long been the domain of neurosurgery and radiotherapy but chemotherapy is now well established as an additional treatment option for many tumor entities in neuro-oncology. This is particularly true for patients with newly diagnosed and relapsing glioblastoma and anaplastic glioma as well as the treatment of medulloblastoma and primary lymphoma of the central nervous system (CNS). In addition to purely histopathological features, treatment decisions including those for chemotherapy are now based increasingly more on molecular tumor profiling. Within the group ...
Source: Der Nervenarzt - March 19, 2015 Category: Neurology Authors: Roth P, Weller M Tags: Nervenarzt Source Type: research

Isocitrate dehydrogenase mutations: new opportunities for translational research.
Abstract Over the last decade, comprehensive genome-wide sequencing studies have enabled us to find out unexpected genetic alterations of metabolism in cancer. An example is the identification of arginine missense mutations of isocitrate dehydrogenases-1 and -2 (IDH1/2) in glioma, acute myeloid leukemia (AML), chondrosarcomas, and cholangiocarcinoma. These alterations are closely associated with the production of a new stereospecific metabolite, (R)-2-hydroxyglutarate (R-2HG). A large number of follow-up studies have been performed to address the molecular mechanisms of IDH1/2 mutations underlying how these events ...
Source: BMB Reports - March 19, 2015 Category: Biochemistry Authors: Keum YS, Choi BY Tags: BMB Rep Source Type: research

Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth.
Abstract Emerging evidence shows that glioblastoma multiforme (GBM) originates from cancer stem cells (CSCs). Characterization of CSC-specific signalling pathways would help identify new therapeutic targets and perhaps lead to the development of more efficient therapies selectively targeting CSCs. Here; we successfully dedifferentiated two patient-derived GBM cell lines into CSC-like cells (induced glioma stem cells, iGSCs) through expression of Oct4, Sox2 and Nanog transcription factors. Transformed cells exhibited significant suppression of epidermal growth factor receptor and its downstream pathways. Compared wi...
Source: J Cell Mol Med - March 19, 2015 Category: Molecular Biology Authors: Olmez I, Shen W, McDonald H, Ozpolat B Tags: J Cell Mol Med Source Type: research

T11TS inhibits angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model.
Abstract Malignant gliomas represent one of the most aggressive and hypervascular primary brain tumors. Angiopoietin-1, the peptide growth factor activates endothelial Tie-2 receptor promoting vessel maturation and vascular stabilization steps of angiogenesis in glioma. Epidermal growth factor receptor (EGFR) and Tie-2 receptor on endothelial cells once activated transmits signals through downstream Raf/MEK/ERK pathway promoting endothelial cell proliferation and migration which are essential for angiogenesis induction. The in vivo effect of sheep erythrocyte membrane glycopeptide T11-target structure (T11TS) on an...
Source: Experimental and Molecular Pathology - March 19, 2015 Category: Pathology Authors: Bhattacharya D, Chaudhuri S, Singh MK, Chaudhuri S Tags: Exp Mol Pathol Source Type: research

Stanniocalcin-1, a new biomarker of glioma progression, is associated with prognosis of patients
Abstract Stanniocalcin-1 (STC1) is a secreted glycoprotein hormone and highly expressed in various types of human malignancies. Although evidence points to the role of STC1 in human cancers, the clinical significance of STC1 expression in glioma has not been established. Here, we investigated the relationship between STC1 expression and clinicopathological significance in glioma. In our study, we selected 60 cases of different grades glioma tissues to detect the expression of STC1. Data showed that the mRNA and protein levels of STC1 in high-grade glioma tissues were significantly higher than that in low-grade tis...
Source: Tumor Biology - March 18, 2015 Category: Cancer & Oncology Source Type: research

Convection-enhancement delivery of platinum-based drugs and Lipoplatin TM to optimize the concomitant effect with radiotherapy in F98 glioma rat model
In conclusion, CED increased the accumulation of platinum drugs in tumor, reduced the toxicity, and resulted in a higher median survival time. The best treatment was obtained in animals treated with carboplatin and irradiated 24 h later. (Source: Investigational New Drugs)
Source: Investigational New Drugs - March 18, 2015 Category: Drugs & Pharmacology Source Type: research

Malignant Transformation of Low-Grade Gliomas in Children: Lessons Learned From Rare Medical Events [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 18, 2015 Category: Cancer & Oncology Authors: Broniscer Tags: CNS Tumors EDITORIALS Source Type: research

BRAF Mutation and CDKN2A Deletion Define a Clinically Distinct Subgroup of Childhood Secondary High-Grade Glioma [Pediatric Oncology]
Conclusion BRAF V600E mutations and CDKN2A deletions constitute a clinically distinct subtype of sHGG. The prolonged course to transformation for BRAF V600E PLGGs provides an opportunity for surgical interventions, surveillance, and targeted therapies to mitigate the outcome of sHGG. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 18, 2015 Category: Cancer & Oncology Authors: Mistry, Zhukova, Merico, Rakopoulos, Krishnatry, Shago, Stavropoulos, Alon, Pole, Ray, Navickiene, Mangerel, Remke, Buczkowicz, Ramaswamy, Guerreiro Stucklin, Li, Young, Zhang, Castelo-Branco, Bakry, Laughlin, Shlien, Chan, Ligon, Rutka, Dirks, Taylor, Gr Tags: Brain Tumors, Translational Oncology, CNS Tumors, Cancer Biomarkers, Pediatric Pediatric Oncology Source Type: research

Health-Related Quality of Life in Stable, Long-Term Survivors of Low-Grade Glioma [Palliative and Supportive Care]
Conclusion Although HRQOL remains mostly preserved in the majority of patients with LGG, a subset of patients experience detectable decline on one or more HRQOL scales despite long-term stable disease. For this subgroup, further research is recommended to better aid patients in dealing with the consequences of LGG. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - March 18, 2015 Category: Cancer & Oncology Authors: Boele, Douw, Reijneveld, Robben, Taphoorn, Aaronson, Heimans, Klein Tags: Brain Tumors, Quality of Life Palliative and Supportive Care Source Type: research

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups
Abstract Cerebral gliomas of World Health Organization (WHO) grade II and III represent a major challenge in terms of histological classification and clinical management. Here, we asked whether large-scale genomic and transcriptomic profiling improves the definition of prognostically distinct entities. We performed microarray-based genome- and transcriptome-wide analyses of primary tumor samples from a prospective German Glioma Network cohort of 137 patients with cerebral gliomas, including 61 WHO grade II and 76 WHO grade III tumors. Integrative bioinformatic analyses were employed to define molecular subgrou...
Source: Acta Neuropathologica - March 18, 2015 Category: Neurology Source Type: research

Docosahexaenoic Acid Alters Gsα Localization in Lipid Raft and Potentiates Adenylate Cyclase
The objective of this study is to investigate the mechanism underling the antidepressant effect of DHA by evaluating Gsα localization in lipid raft and the activity of adenylate cyclase in an in vitro glioma cell model. (Source: Nutrition)
Source: Nutrition - March 18, 2015 Category: Nutrition Authors: Zhuoran Zhu, Zhoubin Tan, Yan Li, Hongyan Luo, Xinwu Hu, Ming Tang, Jürgen Hescheler, Yangling Mu, Lanqiu Zhang Source Type: research

Extracellular Matrix Glycoprotein-Derived Synthetic Peptides Differentially Modulate Glioma and Sarcoma Cell Migration.
In this study, we have investigated the biological effects of peptides derived from collagen type IV and tenascin-C compared to the well-known RGD peptide originally discovered in fibronectin. The influence of glycoproteins and corresponding peptides on the migration of the glioma cell lines U-251-MG and U-373-MG and the sarcoma line S-117 was studied. When the cell lines were tested in a modified Boyden chamber assay on filters coated with the ECM glycoproteins, glioma cells showed a strong migration response on tenascin-C and the basal lamina constituent collagen IV, in contrast to S-117 cells. In order to identify relev...
Source: Cellular and Molecular Neurobiology - March 18, 2015 Category: Cytology Authors: Brösicke N, Sallouh M, Prior LM, Job A, Weberskirch R, Faissner A Tags: Cell Mol Neurobiol Source Type: research

Dynamic Contrast-Enhanced MRI in the Study of Brain Tumors. Comparison Between the Extended Tofts-Kety Model and a Phenomenological Universalities (PUN) Algorithm
In conclusion, we can confirm that the application of the EU1 model to the DCE-MRI experimental data might be a useful alternative to pharmacokinetic models in the study of BT, because the analytic results can be generated more quickly and easily than with the ETK model. (Source: Journal of Digital Imaging)
Source: Journal of Digital Imaging - March 17, 2015 Category: Radiology Source Type: research

Focused ultrasound-induced blood–brain barrier opening to enhance interleukin-12 delivery for brain tumor immunotherapy: a preclinical feasibility study
Conclusion: This study provides evidence that FUS-BBB opening can enhance immune-modulating agent delivery to the brain, which improve the anticancer immune response in brain tumor treatment. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 17, 2015 Category: Research Authors: Pin-Yuan ChenHan-Yi HsiehChiung-Yin HuangChun-Yen LinKuo-Chen WeiHao-Li Liu Source Type: research

Proteomic screening and identification of microRNA‐128targets in glioma cells
This article is protected by copyright. All rights reserved (Source: Proteomics)
Source: Proteomics - March 17, 2015 Category: Biochemistry Authors: Bin Yang, Shan Wang, Jiawei Zeng, Yu Zhang, Xiangbin Ruan, Wei Han, Bin Yin, Jiangang Yuan, Boqin Qiang, Wantao Ying, Xiaohong Qian, Xiaozhong Peng Tags: Research Article Source Type: research

CT Perfusion with Acetazolamide Challenge in C6 Gliomas and Angiogenesis
This study was performed to investigate the correlation between CT perfusion with acetazolamide challenge and angiogenesis in C6 gliomas. Methods Thirty-two male Sprague-Dawley rats were evaluated. The rats were divided randomly to four groups: eight rats with orthotopically implanted C6 gliomas at 10-days old (Group A), eight rats with gliomas at 14-days old (Group B), eight rats with gliomas at 18-days old (Group C), eight rats with orthotopically injected normal saline served as controls. CT perfusion was performed before and after administration of acetazolamide. Changes in perfusion parameters due to acetazolamide adm...
Source: PLoS One - March 17, 2015 Category: Biomedical Science Authors: Na Lu et al. Source Type: research

Variable phenotypes in Greig cephalopolysyndactyly sydrome (GCPS) and their relevance to plastic surgery
Conclusion An awareness of the diversity in phenotypes is important for diagnosis and early referral for genetic confirmation and counselling. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - March 17, 2015 Category: Journals (General) Source Type: research

Gene of the month: PIK3CA
PIK3CA encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K) which through its role in the PI3K/Akt pathway is important for the regulation of important cellular functions such as proliferation, metabolism and protein synthesis, angiogenesis and apoptosis. Mutations in PIK3CA are known to be involved in a wide range of human cancers and mutant PIK3CA is thought to act as an oncogene. The specific PIK3CA inhibitor, NVP-BYL719, has displayed promising results in cancer therapy and is currently under clinical trials. Furthermore, PI3K regulates autophagy, a cellular process that recycles proteins a...
Source: Journal of Clinical Pathology - March 17, 2015 Category: Pathology Authors: Lai, K., Killingsworth, M. C., Lee, C. S. Tags: Molecular genetics, Neurooncology, CNS cancer Gene of the month Source Type: research

Akt3 activates DNA repair pathway [Cell Biology]
Akt is a robust oncogene that plays key roles in the development and progression of many cancers, including glioma. We evaluated the differential propensities of the Akt isoforms toward progression in the well-characterized RCAS/Ntv-a mouse model of PDGFB-driven low grade glioma. A constitutively active myristoylated form of Akt1 did not... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - March 17, 2015 Category: Science Authors: Turner, K. M., Sun, Y., Ji, P., Granberg, K. J., Bernard, B., Hu, L., Cogdell, D. E., Zhou, X., Yli-Harja, O., Nykter, M., Shmulevich, I., Yung, W. K. A., Fuller, G. N., Zhang, W. Tags: Biological Sciences Source Type: research