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This page shows you the latest news and research items in this category.

Clinical and molecular aspects of androgen insensitivity.
Abstract Androgen insensitivity describes the inability of cells to respond adequately to androgens. The clinical aspects are well characterized and described in the androgen insensitivity syndrome, where underandrogenization occurs despite normal to high levels of androgens. In 46,XY individuals, this is associated with a variable phenotype ranging from completely female to ambiguous genitalia and infertility in males with gynecomastia. Androgen action is facilitated by a single androgen receptor (AR), whose gene is localized on the X chromosome. However, the identification of mutations in the AR gene in patients ...
Source: Endocrine Development - February 10, 2013 Category: Endocrinology Authors: Hiort O Tags: Endocr Dev Source Type: research

A 47,X,+t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2),Y Klinefelter Variant with Morbid Obesity.
We report the case of a 35-yr-old man with hypogonadism and morbid obesity and diabetes mellitus. He had gynecomastia, small testes and penis, very sparse body hair and his body mass index was 44.85. He did not report experiencing broken voice and was able to have erections. We conducted a chromosome study. His genotype was 47,X,+t(X;X)(p22.3;p22.3)del(X)(p11.23q11.2). In this case, the patient was diagnosed as Klinefelter syndrome. He showed rare phenotypes like morbid obesity and average height and the phenotype may be caused by the karyotype and the excess number of X chromosome. Further studies of the relationship betw...
Source: Yonsei Medical Journal - February 3, 2013 Category: Universities & Medical Training Authors: Kim Y, Kim WJ, Huh JH, Lee S, Kim D, Hong JW, Lee EJ Tags: Yonsei Med J Source Type: research

Prepubertal unilateral gynecomastia and the presence of 47,XXY mosaicism in breast epithelial cells: a case report
Abstract: Breast enlargement in prepubertal boys is a rare condition. This case report describes an otherwise healthy 3-year old non-obese boy who developed a large unilateral cystic breast mass measuring approximately 9 × 6 × 4cm. The mass was initially treated as a lymphatic malformation, and sclerotherapy with Picibanil® (OK-432) was attempted without any detectable effect on size. The mass was later excised. The pathological examination revealed mammary gland tissue suggestive of idiopathic gynecomastia. FISH revealed 47, XXY mosaicism in the abnormal breast epithelial cells, but not in peripheral blood lymphocytes....
Source: Journal of Pediatric Surgery - February 1, 2013 Category: Surgery Authors: Peter Stemann Andersen, Bodil Laub Petersen, Anders Juul, Mikael Andersen Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: research

Endocrinological issues and hormonal manipulation in children and men with Klinefelter syndrome
Abstract 47, XXY or Klinefelter syndrome (KS), the most common chromosomal aberration in males, is characterized by either absolute or relative hypogonadism with frequent decline in serum testosterone (T) following the onset of puberty. Decreased T levels are the result of testicular dysfunction with decrease in size of Leydig cells, and loss of germs and Sertoli cells leading to tubular hyalinization. Increase in estradiol results from over‐expression of aromatase CYP19. Deficient androgen production and observed varied response of end‐organs to T leads to delayed progression of puberty with decreased facial/body hair...
Source: American Journal of Medical Genetics Part C: Seminars in Medical Genetics - January 18, 2013 Category: Genetics & Stem Cells Authors: Matthew S. Wosnitzer, Darius A. Paduch Tags: Article Source Type: research

Antidepressant-selective gynecomastia.
CONCLUSIONS: Gynecomastia is associated with antidepressants and other medications but is rarely addressed. Gynecomastia may be antidepressant selective or may be the result of additive adverse effects. Clinicians are advised to question patients regarding this potential adverse effect. Further education of clinicians is indicated. PMID: 23324513 [PubMed - in process] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 1, 2013 Category: Drugs & Pharmacology Authors: Kaufman KR, Podolsky D, Greenman D, Madraswala R Tags: Ann Pharmacother Source Type: research

Unilateral Gynecomastia and Hypokalemic Periodic Paralysis as First Manifestations of Graves' Disease.
Abstract ABSTRACT:: A 39-year-old Chinese man presented to the study hospital with right-sided gynecomastia. Underlying Graves' disease was not diagnosed until recurrent episodes of hypokalemic periodic paralysis were observed. The estradiol (E2) and progesterone levels and the E2-to-testosterone (T) (E2/T) ratio of the patient were elevated before treatment. Immediate intravenous potassium supplementation was started to reverse the paralysis. Additionally, antithyroid drugs were administered to restore a euthyroid state. After treatment, the patient gained strength. Gynecomastia regressed with a return to the euth...
Source: The American Journal of the Medical Sciences - December 28, 2012 Category: Journals (General) Authors: Wang Y, Zhao L, Li F, Chen HX, Fang F, Peng YD Tags: Am J Med Sci Source Type: research

Alan Turing pardon: we need a shift in legal position | Alex Bailin and John Halford
The courts may need to help the government overcome its blindness towards this unremedied injusticeCalls have resurfaced for Alan Turing to be posthumously pardoned recently. He was prosecuted in 1952 for consensual homosexual acts under section 11 of the Criminal Law Amendment Act 1885 which criminalised "gross indecency" between men – the very same law under which Oscar Wilde had been prosecuted at the end of the nineteenth century. This is an ongoing stain on our society – and something needs to be done about it; if not by parliament then the courts may have to step in.A brilliant mathematician and logician who led ...
Source: Guardian Unlimited Science - December 19, 2012 Category: Science Authors: Alex Bailin, John Halford Tags: Comment Alan Turing Sexuality World news guardian.co.uk UK criminal justice Gay rights Society Law UK news Science Source Type: news

Review: Eplerenone is not more effective for reducing mortality than other aldosterone antagonists.
CONCLUSION Based on an indirect comparison, eplerenone is not more effective at reducing mortality for adults with left ventricular dysfunction than other aldosterone antagonists.Eplerenone or other AAs vs control in patients with left ventricular dysfunction†OutcomesNumber of trials (n)Weighted event ratesAt 2 to 24 moEplerenoneControl‡RRR (95% CI)NNT (CI)All-cause mortality2 (9369)14%16%15% (7 to 23)41 (27 to 88)CV mortality2 (9369)12%14%17% (8 to 25)42 (29 to 88)Gynecomastia2 (9361)0.49%0.66%26% (-27 to 57)NSRRI (CI)NNH (CI)Hyperkalemia3 (9489)6.1%3.8%72% (19 to 147)37 (19 to 140)Other AA§Control‡RRR (95% CI)NNT ...
Source: Annals of Internal Medicine - December 18, 2012 Category: Internal Medicine Authors: Lader E Tags: Ann Intern Med Source Type: research

Spironolactone, eplerenone and the new aldosterone blockers in endocrine and primary hypertension
Mineralocorticoid receptor antagonists (MRAs) are commonly used to reduce blood pressure, left-ventricular hypertrophy, and urinary albumin excretion in patients with essential hypertension or primary aldosteronism. Effects of MRAs on hypertensive organ damage seem to occur beyond what is expected from the mere reduction of blood pressure. This suggests that activation of the mineralocorticoid receptor plays a central role in the development of cardiac and renal abnormalities in hypertensive patients. However, broad use of classic MRAs such as spironolactone has been limited by significant incidence of gynecomastia and oth...
Source: Journal of Hypertension - December 10, 2012 Category: Cardiology Tags: Reviews Source Type: research

[New technique applicable to the correction of gynecomastia and mastectomy performed as part of transsexualism woman to man with major skin excess.]
PMID: 23218479 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)
Source: Annales de Chirurgie Plastique et Esthetique - December 3, 2012 Category: Cosmetic Surgery Authors: Al Mutairi K, Sawaya E, Rousvoal A Tags: Ann Chir Plast Esthet Source Type: research

Gynecomastia: When is treatment indicated?
Abstract This algorithmic approach can simplify your clinical evaluation and help you decide whether intervention or watchful waiting is appropriate. PMID: 23313989 [PubMed - in process] (Source: The Journal of Family Practice)
Source: The Journal of Family Practice - December 1, 2012 Category: Practice Management Authors: Morcos RN, Kizy T Tags: J Fam Pract Source Type: research

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules.
This article focuses on gynecomastia associated with antiandrogen-based hormonal treatment and shortly reviews the currently most often used therapeutic options for preventing and treating this pathology. PMID: 23128186 [PubMed - as supplied by publisher] (Source: Oncology)
Source: Oncology - November 2, 2012 Category: Cancer & Oncology Authors: Alesini D, Iacovelli R, Palazzo A, Altavilla A, Risi E, Urbano F, Manai C, Passaro A, Magri V, Cortesi E Tags: Oncology Source Type: research

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules
Oncology 2013;84:92–99 (DOI:10.1159/000343821) (Source: Karger Publishers)
Source: Karger Publishers - November 1, 2012 Category: Cancer & Oncology Source Type: research

Metastatic hepatocellular carcinoma presenting as gynecomastia in male: A diagnostic dilema in fine needle aspiration cytology
Jitendra G Nasit, Birwa Shah, Manoj ShahCytoJournal 2012 9(1):21-21 (Source: CytoJournal)
Source: CytoJournal - October 23, 2012 Category: Pathology Authors: Jitendra G NasitBirwa ShahManoj Shah Source Type: research

Hernia Uteri Inguinalis in a Case of Ovotesticular Disorder of Sexual Differentiation
Abstract: An 18-year-old phenotypic male presented with an irreducible left inguinal mass, gynecomastia, and hypospadias. This mass on exploration was found to be a nonfunctional uterus with ipsilateral ovary and was excised. Further investigation confirmed the presence of a contralateral testis and a genotype of 46, XX. This confirmed the diagnosis of ovotesticular disorder of sexual differentiation (formerly true hermaphroditism) with obstructed hernia uteri inguinalis. The patient was raised as a male. Subcutaneous mastectomy for gynecomastia and neourethra construction with full thickness skin graft for hypospadias wer...
Source: Journal of Pediatric and Adolescent Gynecology - October 19, 2012 Category: OBGYN Authors: Aniketh Venkataram, Sadashivaiah Shivaswamy, Rajashekara Babu, Shivashankar Santhosh Tags: Case Reports Source Type: research

The Efficacy of Tamoxifen in the Treatment of Primary Gynecomastia: An Observational Study of Tamoxifen Versus Observation Alone
(Source: The Breast Journal)
Source: The Breast Journal - October 19, 2012 Category: Cancer & Oncology Authors: Ruth James, Farid Ahmed, Giles Cunnick Tags: Letter to the Editor Source Type: research

Gynecomastia treatment using radiofrequency-assisted liposuction (RFAL)
Conclusions The mixed technique presented in this study appears to be safe and effective. The RFAL mixed technique has proven to be superior to ultrasonic and power-assisted liposuction due to the skin contraction, having no limitation dependent on the quality of the patient’s skin. Level of Evidence: Level IV, therapeutic study. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s00238-012-0772-5Authors Guillermo Blugerman, Centros B & S “Excelencia en Cirugía Plástica”, Buenos Aires, CABA, ArgentinaDiego Schalvezon, Centros B & S “Excelencia en Cirugía Plástic...
Source: European Journal of Plastic Surgery - October 12, 2012 Category: Cosmetic Surgery Tags: European Journal of Plastic Surgery Source Type: research

Gynecomastia Induced by Prostate-Cancer Treatment
New England Journal of Medicine, Volume 367, Issue 15, Page 1449, October 2012. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 10, 2012 Category: Internal Medicine Tags: article Source Type: research

Panax ginseng: a newly identified cause of gynecomastia.
In conclusion, physicians should consider ginseng in the investigation of gynecomastia. PMID: 23006978 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 7, 2012 Category: Research Authors: Kakisaka Y, Ohara T, Tozawa H, Sato S, Katayama S, Suzuki T, Hino-Fukuyo N, Kure S Tags: Tohoku J Exp Med Source Type: research

Male Breast Enlargement (Gynecomastia)
WebMD explains the causes of gynecomastia, or male breast enlargement, and what men can do to reduce their "man boobs." (Source: WebMD Health)
Source: WebMD Health - September 28, 2012 Category: Consumer Health News Source Type: news

Gynecomastia: Is it cost-effective to investigate all patients in a financially restrained nhs?
Aim: Gynecomastia is a common condition, with many men being referred to the already busy rapid access breast clinic. As surgery for gynecomastia is classed as non-essential, is it cost-effective to investigate all patients? (Source: International Journal of Surgery)
Source: International Journal of Surgery - September 28, 2012 Category: Surgery Authors: Habib Tafazal, Hiren Chauhan, Mehboob Mirza Tags: Abstracts from the Assocation of Surgeons in Training Conference Source Type: research

Thirty-three-year-old Man Presents With Abdominal Mass With Empty Scrotum
A 33-year-old healthy Hispanic man with no medical history presented to an outside facility with an abdominal mass that had been enlarging for 6 months. There had been a delay in his presentation owing to a lack of insurance. He had no signs of infection. He denied shortness of breath, cough, gynecomastia, or other complaints. The patient was married, with normal sexual function. His medical history was significant for bilateral undescended testes for which he had not had previous treatment. His surgical history included an inguinal hernia repair on the right side approximately 8 years previously in Mexico without mention ...
Source: Urology - September 20, 2012 Category: Urology & Nephrology Authors: Michael A. Liss, Antoine Khoury, Atreya Dash Tags: Grand Rounds Source Type: research

J&J Sees Male Breasts And Quickly Settles Risperdal Suit
Was Johnson & Johnson worried what would happen when Aaron Banks took the stand to testify that its Risperdal antipsychotic allegedly caused him to grow breasts? Just as a trial in a Pennsylvania state court was about to begin, the health care giant settled the case, the first of dozens of such lawsuits charging the pill has caused gynecomastia – the abnormal development of large mammary glands in males – but labeling lacked sufficient warnings. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 11, 2012 Category: Pharmaceuticals Authors: Ed Silverman Source Type: news

Surgical Correction of Gynecomastia with Minimal Scarring
Conclusions Use of PAL and a cartilage shaver for the treatment of gynecomastia allows for effective removal of both the fat and the glandular tissue of the breast through a minimal periareolar incision. This technique can achieve excellent aesthetic results with inconspicuous scarring. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Content Type Journal ArticleCatego...
Source: Aesthetic Plastic Surgery - September 7, 2012 Category: Cosmetic Surgery Tags: Aesthetic Plastic Surgery Source Type: research

Familial epilepsy in the pharaohs of ancient Egypt's eighteenth dynasty.
Abstract The pharaohs of Egypt's famous eighteenth dynasty all died early of unknown causes. This paper comprehensively reviews and analyses the medical literature and current evidence available for the New Kingdom rulers - Tuthmosis IV, Amenhotep III, Akhenaten, Smenkhkare and Tutankhamun. The integration of these sources reveals that the eighteenth dynasty rulers may have suffered from an inherited condition that may explain their untimely deaths. The description of recurring strong religious visions, likely neurological disease and gynecomastia, supports the theory that these pharaohs may have suffered from a fa...
Source: Epilepsy and Behaviour - September 1, 2012 Category: Neurology Authors: Ashrafian H Tags: Epilepsy Behav Source Type: research

Gynecomastia caused by ethionamide
Parveen K Sharma, Rekha BansalIndian Journal of Pharmacology 2012 44(5):654-655A 43 year old male patient, known case of multidrug resistant tuberculosis, was prescribed antitubercular drugs: kanamycin, levofloxacin, ethionamide, terizidone, Para-Aminosalicylate Sodium (PAS), pyrazinamide and pyridoxine. After 4 months of treatment, the patient developed a lump in the right breast which was approximately around 3 × 3 cm in size, tender on palpation, and not fixed to the underlying tissues. Ultrasonography (USG) revealed a hypoechoic mass of size 2.5 × 0.92 × 2.6 cm in the right breast re...
Source: Indian Journal of Pharmacology - August 31, 2012 Category: Drugs & Pharmacology Authors: Parveen K SharmaRekha Bansal Source Type: research

Side Effects Of Treatment For Prostate Cancer Reduced
New research published in BioMed Central's open access journal BMC Medicine reassessing clinical data from trials, which investigate ways of treating side effects of therapy for prostate cancer, finds that tamoxifen, an anti-estrogen used to treat breast cancer, is also able to suppress gynecomastia and breast pain in men. Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. Androgen-suppression therapy is often used to slow down progression of advanced disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 29, 2012 Category: Consumer Health News Tags: Prostate / Prostate Cancer Source Type: news

IGF-1 administration ameliorates disease manifestations in a mouse model of spinal and bulbar muscular atrophy.
Abstract Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive proximal muscle weakness, muscle atrophy, and fasciculations. Affected individuals often show gynecomastia, testicular atrophy, and reduced fertility as a result of mild androgen insensitivity. No effective disease-modifying therapy is currently available for this disease. Our recent studies have demonstrated that insulin-like growth factor 1 (IGF-1) reduces the mutant androgen receptor toxicity through activation of Akt in vitro, and spinal ...
Source: Molecular Medicine - August 29, 2012 Category: Molecular Biology Authors: Rinaldi C, Bott LC, Chen KL, Harmison GG, Katsuno M, Sobue G, Pennuto M, Fischbeck KH Tags: Mol Med Source Type: research

Reducing the side effects of treatment for prostate cancer
New research reassessing clinical data from trials, which investigate ways of treating side effects of therapy for prostate cancer, finds that tamoxifen, an anti-estrogen used to treat breast cancer, is also able to suppress gynecomastia and breast pain in men. Prostate cancer is one of the most common cancers in men and early treatment is usually very successful. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 27, 2012 Category: Science Source Type: news

Reducing the side effects of treatment for prostate cancer
(BioMed Central) New research published in BioMed Central's open access journal BMC Medicine reassessing clinical data from trials, which investigate ways of treating side effects of therapy for prostate cancer, finds that tamoxifen, an anti-estrogen used to treat breast cancer, is also able to suppress gynecomastia and breast pain in men. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 27, 2012 Category: Cancer & Oncology Source Type: news

Klinefelter's syndrome associated with progressive muscular atrophy simulating Kennedy's disease
Pedro Enrique Jiménez CaballeroAnnals of Indian Academy of Neurology 2012 15(3):227-229Kennedy's disease, an X-linked spinal and bulbar muscular atrophy, is characterized by loss of lower motor neurons. Mild sensory deficits, gynecomastia and infertility may be observed. Klinefelter's syndrome is a variation of sex chromosome disorder characterized by hypogonadism, gynecomastia and azoospermia, and the most frequent karyotype is XXY. A 55-year-old man who presented with slowly progressive and diffuse neurogenic muscle atrophy without bulbar or sensory symptoms. He also had Klinefelter's syndrome...
Source: Annals of Indian Academy of Neurology - August 14, 2012 Category: Neurology Authors: Pedro Enrique Jiménez Caballero Source Type: research

Gynecomastia: physiopathology, evaluation and treatment.
Abstract Gynecomastia (GM) is characterized by enlargement of the male breast, caused by glandular proliferation and fat deposition. GM is common and occurs in adolescents, adults and in old age. The aim of this review is to discuss the pathophysiology, etiology, evaluation and therapy of GM. A hormonal imbalance between estrogens and androgens is the key hallmark of GM generation. The etiology of GM is attributable to physiological factors, endocrine tumors or dysfunctions, non-endocrine diseases, drug use or idiopathic causes. Clinical evaluation must address diagnostic confirmation, search for an etiological fac...
Source: Sao Paulo Medical Journal - August 9, 2012 Category: Journals (General) Authors: Barros AC, Sampaio Mde C Tags: Sao Paulo Med J Source Type: research

Class III gynecomastia in pediatric age: a new modified surgical treatment
Conclusion The technique used meets safety and efficacy standards for the treatment of this type of pediatric gynecomastia. It also offers the best possible aesthetic results with minimum complications which can be treated without the need of further surgery. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00383-012-3155-xAuthors Nicola Zampieri, Department of Surgical Science, Policlinico “G.B.Rossi”, Pediatric Surgical Unit, University of Verona, Piazzale L.A. Scuro, 37134 Verona, ItalyRoberto Castellani, Department of Surgery, “Casa di Cura San Francesco” Hospita...
Source: Pediatric Surgery International - August 9, 2012 Category: Surgery Tags: Pediatric Surgery International Source Type: research

Effectiveness of Gonadotropin Administration for Spermatogenesis Induction in Hypogonadotropic Hypogonadism: A Possible Role of Androgen Receptor CAG Repeat Polymorphism and Therapeutic Measures.
Abstract Prepuberal-onset (PRHH) and postpuberal-onset (PSHH) Hypogonadotropic Hypogondism (HH) refer to a heterogeneous group of patients, showing a broad spectrum of clinical signs and symptoms of androgen deficiency in consideration of the different possible aetiologies and the age at onset. These patients, though, required Gonadotropin treatment (GnTh) by means of administration of both the β Human Chorionic Gonodadotropin (β HCG) and the Follicle Stimulating Hormone (FSH) to obtain mature sperms in the ejaculate aiming to reach fertility levels. However, the response to GnTh is always unpredictable concernin...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 7, 2012 Category: Endocrinology Authors: Giagulli VA, Triggiani V, Corona G, Carbone MD, Tafaro E, Licchelli B, Resta F, Sabba C, Maggi M, Guastamacchia E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

A rare case of unilateral gynecomastia during antituberculous chemotherapy with isoniazid
BK Manjunatha Goud, Oinam Sarsina Devi, Bhavna Nayal, RN DevakiIndian Journal of Pharmacology 2012 44(4):521-522Gynecomastia refers to enlargement of male breast (s) due to benign proliferation of glandular tissue and is caused by excessive estrogen. The etiology may be pathological, pharmacological, or idiopathic reasons. The present report describes a case of gynecomastia due to isoniazid therapy. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2012 Category: Drugs & Pharmacology Authors: BK Manjunatha GoudOinam Sarsina DeviBhavna NayalRN Devaki Source Type: research

Dynamic-Definition Male Pectoral Reshaping and Enhancement in Slim, Athletic, Obese, and Gynecomastic Patients Through Selective Fat Removal and Grafting
Conclusion Implants are no longer the only option for defining and augmenting the male chest. Combining fat grafting in a multilayer fashion with precise anatomic fat and gland removal achieved a contoured and athletic male pectoral in a safe and reproducible manner. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. Content Type Journal ArticleCategory Innovative Techni...
Source: Aesthetic Plastic Surgery - July 26, 2012 Category: Cosmetic Surgery Tags: Aesthetic Plastic Surgery Source Type: research

Gynecomastia: a rare complication of isoretinoin?
We present a case with 20 years old man who developed gynecomastia after treatment with isotretinoin. To the best of our knowledge, this is the third report of the development of gynecomastia after isotretinoin treatment. PMID: 22813063 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
Source: Cutaneous and Ocular Toxicology - July 20, 2012 Category: Toxicology Authors: Ustun I, Rifaioglu EN, Sen BB, Inam MU, Gokce C Tags: Cutan Ocul Toxicol Source Type: research

Prevention of Gynecomastia and Breast Pain Caused by Androgen Deprivation Therapy in Prostate Cancer: Tamoxifen or Radiotherapy?
Purpose: To determine, in a meta-analysis, whether gynecomastia and breast pain rates in men with prostate cancer treated with androgen deprivation therapy (ADT) are reduced if treated with prophylactic radiotherapy (RT) or tamoxifen (TMX).Methods and Materials: The MEDLINE, EMBASE, CANCERLIT, and Cochrane Library databases, as well as proceedings of annual meetings, were systematically searched to identify randomized, controlled studies comparing RT or TMX with observation for men with prostate cancer using ADT.Results: Six RCTs (three RT trials and three TMX trials, N = 777 patients total) were identified that met the st...
Source: International Journal of Radiation Oncology * Biology * Physics - June 20, 2012 Category: Radiology Authors: Gustavo Arruda Viani, Lucas Godói Bernardes da Silva, Eduardo Jose Stefano Tags: Genitourinary Cancers Source Type: research

Cycling may negatively affect male reproductive health, UCLA study finds
A study by researchers at the UCLA School of Nursing has found that serious male cyclists may experience hormonal imbalances that could affect their reproductive health. The study, "Reproductive Hormones and Interleukin-6 in Serious Leisure Male Athletes," was recently published in the European Journal of Applied Physiology. To date, an extensive amount of research has been done documenting the positive effects of long-term exercise on health. Yet while moderate exercise can lead to enhanced cardiovascular and metabolic function and reduced body fat, studies have shown that ultra-endurance...
Source: UCLA Newsroom: Health Sciences - May 21, 2012 Category: Universities & Medical Training Source Type: news

Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast: A Series of 24 Patients
This study suggests that PASH is primarily a diagnosis of premenopausal and perimenopausal women. Our series supports a hormonal basis for its development due to the positive staining for hormonal receptors. Management is conservative surgery for larger masses with careful observation being an option in patients not at high risk for breast cancer. (Source: The Breast Journal)
Source: The Breast Journal - May 14, 2012 Category: Cancer & Oncology Authors: Erin Bowman, Gabriela Oprea, Joel Okoli, Kathleen Gundry, Monica Rizzo, Sheryl Gabram‐Mendola, Upender Manne, Geoffrey Smith, Stefan Pambuccian, Harvey L. Bumpers Tags: ORIGINAL ARTICLE Source Type: research

Male acquired hypogonadotropic hypogonadism: Diagnosis and treatment.
Abstract Acquired hypogonadotropic hypogonadism (AHH), contrary to congenital hypogonadotropic hypogonadism (CHH) is characterized by postnatal onset of disorders that damage or alter the function of gonadotropin-releasing hormone (GnRH) neurons and/or pituitary gonadotroph cells. AHH thus prevents the establishment of gonadotropin secretion at puberty, or its post-pubertal maintenance. Thus, postnatal AHH may prevent the onset of puberty or appear during pubertal development, but it usually emerges after the normal age of puberty. Although pituitary tumors, particularly prolactinoma, are the most common cause, sel...
Source: Annales d'Endocrinologie - April 25, 2012 Category: Endocrinology Authors: Salenave S, Trabado S, Maione L, Brailly-Tabard S, Young J Tags: Ann Endocrinol (Paris) Source Type: research

[The cardiologist and immunosuppressive therapy.]
Abstract The monitoring of immunosuppressive therapy may involve the cardiologist in various settings. TNF inhibitors are contra-indicated in patients with NYHA III-IV cardiac failure. This contra-indication is not absolute for etanercept. In patients with milder forms of cardiac failure, TNF inhibitors can be prescribed in the absence of alternative therapy. A cardiac follow-up is necessary in this situation. Cyclosporine and tacrolimus are both nephrotoxic and hypertensive drugs. For the treatment of arterial hypertension induced by the immunosuppressive therapy, first-line recommended drugs are calcium-blockers ...
Source: Presse Medicale - April 20, 2012 Category: Journals (General) Authors: Ambrosi P, Lafforgue P Tags: Presse Med Source Type: research

Unilateral gynecomastia and pseudoangiomatous stromal hyperplasia in neurofibromatosis: Case report and review of the literature.
Abstract In this article, we describe unilateral gynecomastia and pseudoangiomatous stromal hyperplasia (PASH) in a case of type-1 neurofibromatosis (NF-1). It is important to distinguish PASH from fibroadenoma clinically, and from true blood capillaries and angiosarcoma histologically. In the present case, giant multinucleated cells lined the pseudovascular spaces, which was markedly different from that of conventional breast PASH. The origin of PASH has been reported to be either the fibroblast or the myofibroblast phenotype and may be affected by endocrine signaling because many cases have been reported in preme...
Source: Pathology, Research and Practice - April 18, 2012 Category: Pathology Authors: Kimura S, Tanimoto A, Shimajiri S, Sasaguri T, Yamada S, Wang KY, Guo X, Sasaguri Y Tags: Pathol Res Pract Source Type: research

Gynecomastia.
Abstract Gynecomastia is defined as benign proliferation of glandular breast tissue in men. Physiologic gynecomastia is common in newborns, adolescents, and older men. It is self-limited, but can be treated to minimize emotional distress and physical discomfort. Nonphysiologic gynecomastia may be caused by chronic conditions (e.g., cirrhosis, hypogonadism, renal insufficiency); use of medications, supplements, or illicit drugs; and, rarely, tumors. Discontinuing use of contributing medications and treating underlying disease are the mainstay of treatment. Medications, such as estrogen receptor modulators, and surge...
Source: American Family Physician - April 1, 2012 Category: Primary Care Authors: Dickson G Tags: Am Fam Physician Source Type: research

Safety of cabergoline in the management of pituitary prolactin-induced symptoms with patients treated with atypical neuroleptics.
Conclusions: Long-term treatment with cabergoline seems to be safe in atypical antipsychotic-treated patients. PMID: 22873493 [PubMed - in process] (Source: Current Drug Safety)
Source: Current Drug Safety - April 1, 2012 Category: Drugs & Pharmacology Authors: Coronas R, Cobo J, Giménez-Palop O, Ortega E, Márquez M Tags: Curr Drug Saf Source Type: research

[Androgen deprivation therapy in prostate cancer : Indication and systemic consequences].
Abstract Androgen deprivation therapy (ADT) is effective in prolonging the progression free survival of patients with symptomatic/metastatic prostate cancer (PC). The reduction of clinical symptoms of tumour disease and the reduction of tumour growth and metastatic dissemination is accompanied by systemic consequences of testosterone deficiency. These are hot flushes, fatigue due to reduction of muscular strength and muscle mass as well as anaemia. Moreover, patients develop cognitive impairment und depressive mood. Weight gain with insulin resistance, disturbances of lipid metabolism and gynecomastia are other eff...
Source: Der Urologe. Ausg. A - April 1, 2012 Category: Urology & Nephrology Authors: Rohayem J, Kliesch S Tags: Urologe A Source Type: research

The Good Guy’s Guide to Lying
According to a Shimer College adjunct faculty member, Dr. Yau (he also holds an MFA in Phrenology) whose team analyzed all 81 students at his school, there are 4 distinct ways to tell if a guy is lying.read more (Source: Psychology Today Personality Center)
Source: Psychology Today Personality Center - March 26, 2012 Category: Psychiatry & Psychology Authors: Slash Coleman, M.A.Ed. Tags: Personality Relationships Self-Help agony and the ecstasy american radio aol Apple apple products auditory Baron von Muchnhausen childhood deceived faithful reader giraffe guilty gynecomastia hallucinations host ira glass Source Type: news

Malignant lymphoma of the breast in a male patient: ultrasound imaging features.
Abstract Non-Hodgkin lymphoma (NHL) of the breast is a rare disease. Herein, we report a rare case of secondary involvement of the breast by NHL in a male patient and the ultrasound imaging findings. A 70-year-old man noticed an induration of the subareolar region of the right breast. He had been diagnosed as having mantle cell lymphoma 5 years before and treated with several series of chemoradiotherapy. On supine examination, palpation revealed bilateral breast enlargement, but detection of a lump was difficult. Ultrasonography showed a hypoechoic non-mass image-forming lesion in the subareolar region of the righ...
Source: Breast Cancer - March 7, 2012 Category: Cancer & Oncology Authors: Ikeda T, Bando H, Iguchi A, Tanaka Y, Tohno E, Hara H Tags: Breast Cancer Source Type: research

Effectiveness of Gonadotropin administration for spermatogenesis induction in hypogonadotropic hypogonadism: a possible role of Androgen Receptor CAG repeat polymorphism and therapeutic measures.
Abstract Prepuberal-onset (PRHH) and postpuberal-onset (PSHH) Hypogonadotropic Hypogondism (HH) refer to a heterogeneous group of patients, showing a broad spectrum of clinical signs and symptoms of androgen deficiency in consideration of the different possible aetiologies and the age at onset. These patients, though, required Gonadotropin treatment (GnTh) by means of administration of both the β Human Chorionic Gonodadotropin (β HCG) and the Follicle Stimulating Hormone (FSH) to obtain mature sperms in the ejaculate aiming to reach fertility levels. However, the response to GnTh is always unpredictable concernin...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 5, 2012 Category: Endocrinology Authors: Giagulli VA, Triggiani V, Corona G, Carbone MD, Tafaro E, Licchelli B, Resta F, Sabbà C, Maggi M, Guastamacchia E Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Laser-assisted lipolysis in the treatment of gynecomastia: a prospective study in 28 patients
This article reports a 5-year experience using laser-assisted lipolysis (LAL) to treat gynecomastia, and describes the surgical technique. Between January 2006 and December 2010, a total of 28 patients with bilateral gynecomastia were treated with LAL. Patients had a mean age of 36.5 years (range 24 to 56 years). LAL was performed with a 980-nm diode laser (continuous emission, 15 W power, 8–12 kJ total energy per breast) after tumescent anesthetic infiltration. The breast was evaluated objectively by two physicians who compared chest circumference and photographs. Patients were also asked to scor...
Source: Lasers in Medical Science - February 21, 2012 Category: Laser Surgery Tags: Lasers in Medical Science Source Type: research