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This page shows you the latest news and research items in this category.

Strategies for the Creation and Maintenance of Reconstructed Arteriovenous Fistulas Using the Forearm Basilic Vein
This study reviewed 76 cases of reconstructed AVF including 18 cases using the basilic vein (23.7% of total cases). The following four points were considered: arm positioning of the cubital flexion position combined with the forearm supinated position; several small skin incisions with a subcutaneous tunnel; sufficient venous dilatation using Fogarty balloon catheter; and early percutaneous angioplasty introduction for immature AVF. The primary and secondary patency rates were examined. A radiobasilic AVF was created through a subcutaneous tunnel in two cases. The primary and secondary patency rates of AVF with the basilic...
Source: Therapeutic Apheresis and Dialysis - February 28, 2013 Category: Hematology Authors: Shintaro Kumano, Keiichi Itatani, Jun Shiota, Satoshi Gojo, Naoki Izumi, Hitoshi Kasahara, Yukio Homma, Hitoshi Tagawa Tags: Original Article Source Type: research

A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension
Conclusion: We report on a rare case of TMA probably due to malignant hypertension in LPG. Early lipid-lowering and antihypertensive treatment may improve outcome. The pathophysiologic relationship between LPG and TMA should be investigated further. (Source: BMC Nephrology)
Source: BMC Nephrology - February 28, 2013 Category: Urology & Nephrology Authors: Yu WuXiaohan ChenYuan YangBaohe WangXiaoxia LiuYe TaoPing FuZhangxue Hu Source Type: research

Factors Influencing Hospital Length of Stay After Robotic Totally Endoscopic Coronary Artery Bypass Grafting [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions Multiple variables affect LOS after TECAB. Older patients, patients on hemodialysis, patients with cerebrovascular disease, and those with higher general risk scores should expect prolonged LOS. Intraoperative surgical difficulties and conversion to open coronary artery bypass grafting also lead to extended LOS. Postoperative events that are known to prolong LOS in open coronary artery bypass grafting also prolong LOS after TECAB. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Lee, J. D., Bonaros, N., Hong, P. T., Kofler, M., Srivastava, M., Herr, D. L., Lehr, E. J., Bonatti, J. Tags: Coronary disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Clinical Outcome After Mitral Valve Surgery Due to Ischemic Papillary Muscle Rupture [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions Papillary muscle rupture with severe mitral regurgitation carries a high operative mortality. Additional CABG does not influence the acute postoperative course. Postoperative development of low cardiac output with a need for extracorporeal membrane oxygenation therapy and renal failure with hemodialysis substantially reduces survival. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Schroeter, T., Lehmann, S., Misfeld, M., Borger, M., Subramanian, S., Mohr, F. W., Bakthiary, F. Tags: Myocardial infarction, Valve disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Associations Between Preoperative Anemia and Outcomes After Off-Pump Coronary Artery Bypass Grafting [ORIGINAL ARTICLES: ADULT CARDIAC]
Conclusions In patients undergoing isolated off-pump CABG, preoperative anemia was not an independent predictor of postoperative adverse events. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - February 28, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Matsuda, S., Fukui, T., Shimizu, J., Takao, A., Takanashi, S., Tomoike, H. Tags: Coronary disease ORIGINAL ARTICLES: ADULT CARDIAC Source Type: research

Optimal Nutrition in Hemodialysis Patients
Protein-energy wasting (PEW) is highly prevalent in patients undergoing maintenance hemodialysis (MHD). It is important to note that there is a robust association between the extent of PEW and the risk of hospitalization and death in these patients, regardless of the nutritional marker used. The multiple etiologies of PEW in advanced kidney disease are still being elucidated. Apart from the multiple mechanisms that might lead to PEW, it appears that the common pathway for all of the derangements is related to exaggerated protein degradation along with decreased protein synthesis. The hemodialysis procedure per se is an imp...
Source: Advances in Chronic Kidney Disease - February 27, 2013 Category: Urology & Nephrology Authors: T. Alp Ikizler Tags: Optimal Nutrition for Kidney Diseases Source Type: research

Non-Pharmaceutical Fatigue Interventions in Adults Receiving Hemodialysis: A Systematic Review
(Source: Advances in Chronic Kidney Disease)
Source: Advances in Chronic Kidney Disease - February 27, 2013 Category: Urology & Nephrology Authors: Kim Schafer Astroth, Cynthia L. Russell, Janet L. Welch Tags: Abtracts Source Type: research

Fibrin Sheath and its Relation to Subsequent Events after Tunneled Dialysis Catheter Exchange
Abstract The use of tunneled catheters (TDC) for chronic hemodialysis is frequent and often fails due to fibrin or thrombus and infection. We hypothesized that the presence of fibrin sheath in TDC increases the risk for subsequent catheter malfunction and infection. We did a retrospective review of TDC exchanges and de novo placements from January 2005 to September 2011. Demographic data, information about the catheter procedure, and radiological data were collected. Final outcome analysis included 168 procedure events. Three groups of catheter procedures were identified: catheter exchange without a fibrin sheath (CE), cat...
Source: Seminars In Dialysis - February 27, 2013 Category: Hematology Authors: Almothana Shanaah, Michael Brier, Amy Dwyer Tags: Investigation Source Type: research

An observational outcomes study from 1966‐2008, examining pregnancy and neonatal outcomes from dialyzed women using data from the ANZDATA Registry
Conclusion79% of women achieving a pregnancy in our cohort achieved a LB, although 53.4% of babies were born pre‐term and 65% were of low birth weight (<2.5 kg). (Source: Nephrology)
Source: Nephrology - February 27, 2013 Category: Urology & Nephrology Authors: A.Kaithal Shahir, N. Briggs, J. Katsoulis, V. Levidiotis Tags: Original Article Source Type: research

Increase in nephrology advanced trainee numbers in Australia and associated reduction in clinical exposure over the past decade
ConclusionsThere has been a dramatic and significant increase in nephrology advanced trainee numbers over the past decade at a more rapid rate than the growth in dialysis and transplant patient numbers. This study suggests that training experience has diminished over the past decade and supports a 3‐year core clinical nephrology training programme in Australia. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - February 27, 2013 Category: Internal Medicine Authors: L. Amos, N. D. Toussaint, R. K. Phoon, T. J. Elias, V. Levidiotis, S. B. Campbell, A. M. Walker, C. Harrex Tags: Original Article Source Type: research

Characteristics of serum C1q-binding adiponectin in patients on maintenance hemodialysis: C1q-binding adiponectin in hemodialysis patients
Conclusions: Low serum C1q-APN and C1q-APN/C1q ratio, but not C1q-APN/Total-APN ratio, correlated with ACVD in HD patients.Trial registration: ClinicalTrials.gov: UMIN 000004318https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000005173&language=E (Source: BioMed Central)
Source: BioMed Central - February 26, 2013 Category: Journals (General) Authors: Ken KishidaNaohiro KishidaMasaaki ArimaHideaki NakatsujiHironori KobayashiTohru FunahashiIichiro Shimomura Source Type: research

Promoting Medication Adherence and Regimen Responsibility in Two Adolescents on Hemodialysis for End-Stage Renal Disease: A Case Study
Medication adherence and regimen responsibility (RR) have important implications for adolescents with hemodialysis-dependent end-stage renal disease (ESRD). This case study assesses the preliminary efficacy of a cognitive-behavioral intervention to promote medication adherence and RR in two African American adolescents. Two patients and their mothers participated. Intervention modules addressed adherence barriers. Using a case-series design, weekly parent–adolescent reports of medication adherence and RR were collected. The female participant’s selective nonadherence improved during treatment. Mother and daught...
Source: Clinical Case Studies - February 26, 2013 Category: Psychiatry Authors: Payne, M. E., Eaton, C. K., Mee, L. L., Blount, R. L. Tags: Articles Source Type: research

Adalimumab treatment in patients with rheumatoid arthritis with renal insufficiency
ConclusionOur data indicate that adalimumab does not worsen renal function and has no serious adverse events even for RA patients with renal insufficiency, including those undergoing hemodialysis, and suggest that it could be a potential therapeutic option for them. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2013 Category: Rheumatology Authors: Keiichi Sumida, Yoshifumi Ubara, Tatsuya Suwabe, Noriko Hayami, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi Tags: Brief Reports Source Type: research

Systemic Amyloidosis
This case highlights the challenges of rendering a diagnosis of systemic amyloidosis due to its pleomorphic presentation. Amyloidosis occurs due to the abnormal deposition of proteins in various organ systems causing a host of unusual symptoms ranging from enlarged muscles, neuropathy, hepatosplenomegaly, and periorbital eccymoses. But while its presentation may be vexing, systemic amyloidosis is a condition which can complicate many illnesses that are prevalent in a geriatric population including inflammatory arthritides, end stage renal disease requiring hemodialysis, multiple myeloma, and inflammatory bowel disease. Thu...
Source: Journal of the American Medical Directors Association - February 25, 2013 Category: Health Management Authors: Kim K. Petrone, Kim K. Petrone, Cheryl Eddinger Nolan Tags: Poster Abstracts Source Type: research

Perioperative Complications of Robot-assisted Partial Nephrectomy: Analysis of 886 Patients at 5 United States Centers
Conclusion: Complication rates in this large multicenter series of RAPN appear to be acceptable and comparable with other nephron-sparing modalities. Most complications (77.0%) are Clavien 1 and 2 and can be managed conservatively. (Source: Urology)
Source: Urology - February 25, 2013 Category: Urology & Nephrology Authors: Youssef S. Tanagho, Jihad H. Kaouk, Mohamad E. Allaf, Craig G. Rogers, Michael D. Stifelman, Bartosz F. Kaczmarek, Shahab P. Hillyer, Jeffrey K. Mullins, Yichun Chiu, Sam B. Bhayani Tags: Laparoscopy and Robotics Source Type: research

Spiritual Coping, Religiosity and Quality of Life: A Study on Muslim Patients Undergoing Hemodialysis
ConclusionSpiritual resources may contribute to better quality of life and health status among hemodialysis patients. Further longitudinal studies are needed to determine whether these associations are causal and the direction of effect. (Source: Nephrology)
Source: Nephrology - February 25, 2013 Category: Urology & Nephrology Authors: Mohsen Saffari, Amir H. Pakpour, Maryam K. Naderi, Harold G. Koenig, Donia R. Baldacchino, Crystal N. Piper Tags: Original Article Source Type: research

Use Of Catheters In Dialysis Linked With High Risk Of Infections, Heart Problems, And Death
Review examines safety of different dialysis procedures to access the blood Highlights Dialysis patients using catheters to access the blood have the highest risks for death, infections, and cardiovascular events compared with patients using other types of vascular access. Higher quality studies are needed to determine the true safety of different types of vascular access used for hemodialysis. Worldwide, more than 1.5 million people are treated with hemodialysis... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 25, 2013 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Phosphate handling by end‐stage kidneys and benefits of residual renal function on phosphate removal in patients on haemodialysis
ConclusionsUPE by end‐stage kidneys depends more on GFR than diminishing TRP. The action of PTH on the kidneys remains until GFR decreases to as low as 3 mL/min. RRF plays a significant role in phosphate elimination, and it is possible that FGF‐23 no longer act effectively to excrete phosphate in the urine in these patients. (Source: Nephrology)
Source: Nephrology - February 25, 2013 Category: Urology & Nephrology Authors: Hideaki Iwasawa, Toshiyuki Nakao, Hiroshi Matsumoto, Tomonari Okada, Yume Nagaoka, Toshikazu Wada Tags: Original Article Source Type: research

Perspectives on death, dying and advance care planning from patients receiving haemodialysis
ConclusionThis study provides an insight into what is important to patients in relation to death, dying and advance care planning. (Source: Journal of Renal Care)
Source: Journal of Renal Care - February 25, 2013 Category: Urology & Nephrology Authors: May Collins, Elaine Lehane Tags: Original Research Source Type: research

The impact of nurse‐led education on haemodialysis patients' phosphate binder medication adherence
ConclusionsA nurse‐led intervention education programme can increase patients' phosphate binder adherence. However, this does not necessarily manifest into improved serum phosphate levels. (Source: Journal of Renal Care)
Source: Journal of Renal Care - February 25, 2013 Category: Urology & Nephrology Authors: Kimberly Sandlin, Paul N Bennett, Cherene Ockerby, Ann‐Marie Corradini Tags: Original Research Source Type: research

Effect of nutritional intervention on malnutrition indicators in patients on haemodialysis
ConclusionNutritional supplementation designed for haemodialysis, improved their nutritional status in the short term study. (Source: Journal of Renal Care)
Source: Journal of Renal Care - February 25, 2013 Category: Urology & Nephrology Authors: Linda Grace Roy, Manjunath S. Shetty, Asna Urooj Tags: Original Research Source Type: research

Colestilan (BindRen®) approved in the EU for treatment of hyperphosphataemia in adults with CKD
Source: European Medicines Agency Area: News Colestilan (BindRen®) has been approved in the EU for the treatment of hyperphosphataemia in adult patients with Chronic Kidney Disease (CKD) Stage 5 receiving haemodialysis or peritoneal dialysis. Further details of this product, including the European Public Assessment Report, are available via link below. (Source: NeLM - News)
Source: NeLM - News - February 25, 2013 Category: Drugs & Pharmacology Source Type: news

Can We Improve Quality of Life in Hemodialysis Patients?
(Source: Seminars In Dialysis)
Source: Seminars In Dialysis - February 25, 2013 Category: Hematology Authors: Scott D. Cohen Tags: Opinion Source Type: research

Spinal ischemic stroke following dialysis: clinical and radiologic findings
Spinal cord ischemia (SCI) is a relatively common cause of noncompressive myelopathy.1 SCI frequently involves the thoracic or lumbar cord manifesting as acute painful paraparesis but may also involve the posterior columns and autonomic fibers.2 Most infarcts affect the central parts of the anterior spinal artery supply.2–4 Outcome depends on the initial severity of the neurologic deficits and may be surprisingly benign especially if proprioception remains intact.1,2 Because hypoperfusion may cause SCI,5,6 our goal was to describe SCI as a potential complication of hemodialysis-associated hypoperfusion. (Source: Neurology)
Source: Neurology - February 25, 2013 Category: Neurology Authors: Honig, A., Gomori, J. M., Schneider, R., Makranz, C., Leker, R. R. Tags: All Medical/Systemic disease, All Cerebrovascular disease/Stroke, All Spinal Cord, Spinal cord infarction, Infarction CLINICAL/SCIENTIFIC NOTES Source Type: research

Hemodiafiltration technique improves mortality in ESRD
High-efficiency online hemodiafiltration reduces mortality over conventional hemodialysis in patients with end-stage renal disease, report researchers. (Source: MedWire News - Urology)
Source: MedWire News - Urology - February 23, 2013 Category: Urology & Nephrology Source Type: news

Hemodiafiltration technique improves mortality in ESRD
High-efficiency online hemodiafiltration reduces mortality over conventional hemodialysis in patients with end-stage renal disease, report researchers. (Source: MedWire News - Cardiology)
Source: MedWire News - Cardiology - February 22, 2013 Category: Cardiology Source Type: news

Risk factors for re-recurrent carpal tunnel syndrome in patients undergoing long-term hemodialysis.
Abstract The purpose of this study was to evaluate risk factors for re-recurrent carpal tunnel syndrome (CTS) in long-term renal hemodialysis (HD) patients. Fifteen wrists of ten HD patients, follow-up period of minimum seven years after reoperation of CTS, were included in this study. Duration of HD, period from first operation to reoperation, shunt side was involved or not, presence of trigger finger and cervical destructive spondyloarthritis, and operative procedure performed during the reoperation (synovectomy was performed or not) were evaluated. Re-recurrent CTS was identified in four out of 15 wrists (27%). ...
Source: Hand Surgery - February 22, 2013 Category: Surgery Authors: Kikuchi K, Matsumoto K, Seo K, Ito Y, Tomari S Tags: Hand Surg Source Type: research

Can we Improve Quality of Life in Hemodialysis Patients?
(Source: Seminars In Dialysis)
Source: Seminars In Dialysis - February 22, 2013 Category: Hematology Authors: Samir S. Patel Tags: Opinion Source Type: research

The A736V TMPRSS6 polymorphism influences hepcidin and iron metabolism in chronic hemodialysis patients: TMPRSS6 and hepcidin in hemodialysis
Conclusions: The A736V TMPRSS6 genotype influences hepcidin levels, erythropoiesis, and anemia management in CHD patients. Evaluation of the effect of TMPRSS6 genotype on clinical outcomes in prospective studies in CHD may be useful to predict the outcomes of hepcidin manipulation, and to guide treatment personalization by optimizing anemia management. (Source: BMC Nephrology)
Source: BMC Nephrology - February 22, 2013 Category: Urology & Nephrology Authors: Serena PelusiDomenico GirelliRaffaela RamettaNatascia CampostriniCarlo AlfieriMichela TragliaPaola DongiovanniGiovanna ComoDaniela TonioloClara CamaschellaPiergiorgio MessaSilvia FargionLuca Valenti Source Type: research

The Benefit of In-Center Oral Protein Supplementation on Hemodialysis Patients
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 21, 2013 Category: Urology & Nephrology Tags: National Kidney Foundation 2013 Spring Clinical Meetings Abstracts Source Type: research

Relationship Between Phosphorus Levels, Race and Age in Chronic Kidney Disease (CKD) Patients on Hemodialysis (HD)
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 21, 2013 Category: Urology & Nephrology Tags: National Kidney Foundation 2013 Spring Clinical Meetings Abstracts Source Type: research

Sarcopenia, Dynapenia and Muscle Atrophy: Are They Associated with Worse Clinical Condition in Elderly Hemodialysis Patients?
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 21, 2013 Category: Urology & Nephrology Tags: National Kidney Foundation 2013 Spring Clinical Meetings Abstracts Source Type: research

Hemodialysis (HD) Patients with Liver Disease: Intradialytic Parenteral Nutrition (IDPN)
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 21, 2013 Category: Urology & Nephrology Tags: National Kidney Foundation 2013 Spring Clinical Meetings Abstracts Source Type: research

March Meeting Announcements
March 9-12, 2013 Annual Dialysis Conference (33rd Annual Dialysis Conference/19th International Symposium on Hemodialysis/24th Annual Symposium on Pediatric Dialysis), Washington State Convention & Trade Center, Seattle, WA. Visit http://som.missouri.edu/dialysis or call (573) 882-4105. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - February 21, 2013 Category: Urology & Nephrology Tags: Announcements Source Type: research

Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients
Conclusions The joint presence of high aldosterone and high cortisol levels is strongly associated with sudden cardiac death as well as all-cause mortality in haemodialysed type 2 diabetic patients. Whether a blockade of the mineralocorticoid receptor decreases the risk of sudden death in these patients must be examined in future trials. (Source: European Heart Journal)
Source: European Heart Journal - February 21, 2013 Category: Cardiology Authors: Drechsler, C., Ritz, E., Tomaschitz, A., Pilz, S., Schonfeld, S., Blouin, K., Bidlingmaier, M., Hammer, F., Krane, V., Marz, W., Allolio, B., Fassnacht, M., Wanner, C. Tags: Arrhythmia/electrophysiology Source Type: research

Long‐term effects of melatonin on quality of life and sleep in hemodialysis patients (Melody study): a randomized controlled trial
ConclusionsThe high drop‐out rate limits the strength of our conclusions. However, although a previous study reported beneficial short‐term effects of melatonin on sleep in hemodialysis patients, in this long‐term study the positive effects disappeared during follow up (6‐12 months). Also the quality of life parameter vitality did not improve. Efforts should be made to elucidate the mechanism responsible for the loss of effect with chronic use. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - February 21, 2013 Category: Drugs & Pharmacology Authors: Marije Russcher, Birgit C P Koch, J Elsbeth Nagtegaal, Frans J Ittersum, Pieternel C M Pasker‐de Jong, E Chris Hagen, Wim Th Dorp, Bas Gabreëls, Thierry X Wildbergh, Monique M L Westerlaken, Carlo A J M Gaillard, Piet M Wee Tags: Clinical trials Source Type: research

Recanalization of Thrombosed Arteriovenous Fistulas for Hemodialysis by Minimal Venotomy
Abstract: The present work describes the preliminary results of a new method of minimally invasive thrombectomy in the treatment of thrombosed arteriovenous fistula (AVF) with dilated aneurysm. Data from 25 patients who were treated with this minimal venotomy technique were retrospectively reviewed. The minimal venotomy was made on the dilated fistula, and thrombectomy was performed with forceps and Fogarty catheters through the venotomy site. Technical and clinical success was achieved in all 25 patients. There were two major and two minor complications (8% each). The two major complications consisted of bleeding at the v...
Source: Journal of Vascular and Interventional Radiology : JVIR - February 20, 2013 Category: Radiology Authors: Seung-Moon Joo, Hyo-Cheol Kim, Sang-Il Min, Saebeom Hur, Hwan Jun Jae, Jin Wook Chung, Jae Hyung Park Source Type: research

T-shaped Angioplasty with Apex Puncture of Thrombosed Looped Hemodialysis Grafts
This study is a retrospective evaluation of an alternative technique for angioplasty of thrombosed loop hemodialysis grafts through a single vascular access. This technique can provide balloon angioplasty to the puncture site without any additional vascular accesses by using a T-shaped balloon catheter and can simplify thrombectomy procedures. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - February 20, 2013 Category: Radiology Authors: Jung Suk Oh, Byung Gil Choi, Ho Jong Chun, Hae Giu Lee Source Type: research

Comparison of methodologies to define hemodialysis patients hyporesponsive to epoetin and impact on counts and characteristics
Background: Some hemodialysis patients require large doses of erythropoiesis-stimulating agents (ESAs) to manage anemia. These patients, termed "ESA hyporesponsive," have been characterized using various definitions. We applied three definitions of hyporesponsiveness to a large, national cohort of hemodialysis patients to assess the impact of definition on counts and on characteristics associated with hyporesponsiveness. Methods: We studied point-prevalent hemodialysis patients on May 1, 2008, with Medicare as primary payer, who survived through December 31, 2008. Included patients received recombinant human erythropoietin...
Source: BMC Nephrology - February 20, 2013 Category: Urology & Nephrology Authors: David GilbertsonYi PengThomas ArnesonStephan DunningAllan Collins Source Type: research

Anti-Inflammatory Profile of Paricalcitol in Hemodialysis Patients: A Prospective, Open-Label, Pilot Study.
In conclusion, paricalcitol administration to HD patients is associated with a beneficial effect on the inflammatory cytokine serum and gene expression profile of PBMC. This effect may contribute to the survival benefits of paricalcitol observed in clinical studies. PMID: 23426718 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: Navarro-González JF, Donate-Correa J, Méndez ML, de Fuentes MM, García-Pérez J, Mora-Fernández C Tags: J Clin Pharmacol Source Type: research

Body size and longitudinal body weight changes do not increase mortality in incident peritoneal dialysis patients of the Brazilian peritoneal dialysis multicenter study
OBJECTIVES: To determine the roles of body size and longitudinal body weight changes in the survival of incident peritoneal dialysis patients. PATIENTS AND METHODS: Patients (n = 1911) older than 18 years of age recruited from 114 dialysis centers (Dec/ 2004-Oct/2007) and participating in the Brazilian Peritoneal Dialysis Multicenter Cohort Study were included. Clinical and laboratory data were collected monthly (except if the patient received a transplant, recovered renal function, was transferred to hemodialysis, or died). RESULTS: Survival analyses were performed using Kaplan-Meier survival curves and Cox proportional h...
Source: Clinics - February 19, 2013 Category: Journals (General) Source Type: research

Vascular access in therapeutic apheresis: Update 2013
This review addresses the types of vascular access available for patients who need therapeutic apheresis (TA). As in hemodialysis, vascular access for TA is chosen based on type of procedure prescribed, the patient's vascular anatomy, the acuity, frequency and duration of treatment, and the underlying disease state. The types of access available include peripheral vein cannulation, central venous catheters: including nontunneled and tunneled catheters, arterio‐venous grafts and arterio‐venous fistulas. Peripheral veins and central venous catheters are most frequently utilized for the acute administration of TA, and may...
Source: Journal of Clinical Apheresis - February 19, 2013 Category: Hematology Authors: Ladan Golestaneh, Michele H. Mokrzycki Tags: Commentary Source Type: research

Endovascular Treatment for Infrainguinal Vessels in Patients With Critical Limb Ischemia: OLIVE Registry, a Prospective, Multicenter Study in Japan With 12-Month Follow-up [Peripheral Artery Disease]
Conclusions— The high reintervention rate notwithstanding, EVT was an effective treatment for Japanese critical limb ischemia patients with infrainguinal disease, with satisfactory AFS and major adverse limb event-free rates. The results of this study will be helpful for the future evaluation of critical limb ischemia therapy. Clinical Trial Registration— URL: http://www.umin.ac.jp/ctr. Unique identifier: UMIN000002830. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - February 19, 2013 Category: Cardiology Authors: Iida, O., Nakamura, M., Yamauchi, Y., Kawasaki, D., Yokoi, Y., Yokoi, H., Soga, Y., Zen, K., Hirano, K., Suematsu, N., Inoue, N., Suzuki, K., Shintani, Y., Miyashita, Y., Urasawa, K., Kitano, I., Yamaoka, T., Murakami, T., Uesugi, M., Tsuchiya, T., Shinke Tags: Peripheral vascular disease, Other Treatment Peripheral Artery Disease Source Type: research

Low serum fetuin A levels and incident stroke in patients with maintenance haemodialysis
ConclusionsFetuin A deficiency is associated with a higher risk of incident stroke among prevalent HD patients. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - February 19, 2013 Category: Journals (General) Authors: Hung‐Yuan Chen, Yen‐Ling Chiu, Shih‐Ping Hsu, Mei‐Fen Pai, Ju‐Yeh Yang, Yu‐Sen Peng Tags: Original Article Source Type: research

Anaphylactoid reaction during first hemofiltration with a PUREMA® polysulfone membrane.
We present a case of a 34 year old woman in the Burn Intensive Care Unit, who developed acute kidney injury requiring renal replacement therapy. She was placed on continuous veno-venous hemofiltration with the NxStage® machine which uses a synthetic PUREMA® polyethersulfone filter sterilized by gamma radiation. Within two minutes of initiating hemofiltration, the patient complained of pruritus as well as dyspnea and became flushed and agitated. She subsequently developed hypotension ultimately resulting in cardiopulmonary arrest. Cardiopulmonary resuscitation was initiated and the patient was given epinephrine with retur...
Source: The International Journal of Artificial Organs - February 19, 2013 Category: Transplant Surgery Authors: Heegard KD, Tilley MA, Stewart IJ, Edgecombe HP, Lundy JB, Renz EM, Chung KK Tags: Int J Artif Organs Source Type: research

Tumor lysis syndrome following trastuzumab for breast cancer: a case report and review of the literature.
We report tumor lysis syndrome in a patient treated with trastuzumab for metastatic breast carcinoma. A 69-year-old woman was diagnosed with multiple liver metastases 1 month after mastectomy. As her liver functions had deteriorated, chemotherapeutic agents were contraindicated and she was treated with trastuzumab alone. On day 6 of the first course of trastuzumab, she developed tumor lysis syndrome. As her liver functions showed deterioration due to multiple hepatic metastases, hemodialysis was contraindicated. Acute renal failure worsened and she died 11 days after the administration of trastuzumab. PMID: 23420376 ...
Source: Breast Cancer - February 19, 2013 Category: Cancer & Oncology Authors: Taira F, Horimoto Y, Saito M Tags: Breast Cancer Source Type: research

Enhanced Vascular Endothelial Growth Factor and Inflammatory Cytokine Removal With Online Hemodiafiltration Over High‐Flux Hemodialysis in Sepsis‐Related Acute Kidney Injury Patients
In conclusion, online HDF in sepsis‐related AKI could provide significantly better removal of VEGF and other cytokines and these were associated with better renal outcome than high‐flux HD. Thus, online HDF would offer a potential role in hypercytokinemic state in sepsis‐related AKI. (Source: Therapeutic Apheresis and Dialysis)
Source: Therapeutic Apheresis and Dialysis - February 17, 2013 Category: Hematology Authors: Wiwat Chancharoenthana, Khajohn Tiranathanagul, Nattachai Srisawat, Paweena Susantitaphong, Asada Leelahavanichkul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam‐Ong Tags: Original Article Source Type: research

Long‐Term Antihypertensive Effects of Aliskiren, a Direct Renin Inhibitor, in Chronic Hemodialysis Patients
Abstract: The renin‐angiotensin‐aldosterone system is not necessarily suppressed in end‐stage renal disease patients undergoing dialysis. Of all the inhibitors of this system, the clinical efficacy of the renin inhibitor, aliskiren, has not been well demonstrated in dialysis patients. We evaluated the antihypertensive effect of aliskiren, administered as a single daily dose of 150 mg for 24 weeks, in 23 chronic hemodialysis patients (age 65 ± 12 years, 15 men and eight women) with blood pressure ≥140/90 mm Hg, and assessed the factors relating to blood pressure reduction. At 4 weeks, the average systo...
Source: Therapeutic Apheresis and Dialysis - February 17, 2013 Category: Hematology Authors: Toshihiko Ishimitsu, Satoshi Ohta, Eri Ohno, Toshiaki Takahashi, Atsushi Numabe, Atsushi Okamura, Shuichi Ohba, Akiko Hashimoto, Hiroaki Matsuoka Tags: Original Article Source Type: research

Autosomal dominant polycystic kidney disease with ectopic unilateral multicystic dysplastic kidney: unilateral ADPKD with ectopic MCDK
Conclusion: Anatomical and genetic abnormality in patients with ADPKD may be more frequent and complex than previously believed. The compensatory capacity in patients with ADPKD is fragile, and missing one kidney could accelerate the deterioration of renal function. (Source: BioMed Central)
Source: BioMed Central - February 17, 2013 Category: Journals (General) Authors: Jing XuDong-Ping ChenZhi-Guo MaoHe-Feng HuangChen-Ming XuCong-Rong WangWei-Ping JiaChang-Lin Mei Source Type: research

What enhanced elimination techniques are useful in critical toxicology patients?
3 out of 5 stars Enhanced Poison Elimination in Critical Care. Ghannoum M, Gosselin S. Adv Chronic Kidney Dis 2013 Jan;20:94-101. Abstract This survey of methods available for enhanced elimination in toxicology cases gives a good overview, but unnecessarily wastes time discussing modalities that now are never used (e.g., forced diuresis and urine acidification). The information would have been more accessible if it had been streamlined to reflect current practice. For instance, the authors list 20 poisons “amenable” to multidose activated charcoal, but in fact the indications for this treatment are limited and...
Source: The Poison Review - February 16, 2013 Category: Toxicology Authors: Leon Tags: Medical critical care enhanced elimination hemodialysis multidose activated charcoal overdose poisoning toxicology Source Type: news