Hepatitis
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Psoriasis treatment guidelines proposed for patients with concomitant HCV
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Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Pediatrics)
Source: MedWire News - Pediatrics - November 21, 2009 Category: Pediatrics Source Type: news
Psoriasis treatment guidelines proposed for patients with concomitant HCV
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Topical therapy and ultraviolet B phototherapy should be considered first-line and second-line therapies for patients with limited psoriasis and concomitant hepatitis C virus infection, suggests a consensus report from the Medical Board of the US National Psoriasis Foundation. (Source: MedWire News - Dermatology)
Source: MedWire News - Dermatology - November 21, 2009 Category: Dermatology Source Type: news
Elevated International Normalized Ratio associated with concurrent use of sorafenib and warfarin.
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CONCLUSION: A 70-year-old man diagnosed with hepatocellular carcinoma experienced an increase in INR values after the addition of sorafenib to his warfarin regimen.
PMID: 19923313 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - November 20, 2009 Category: Drugs & Pharmacology Authors: Moretti LV, Montalvo RO Tags: Am J Health Syst Pharm Source Type: journals
Value of Diffusion-Weighted MRI for Assessing Liver Fibrosis and Cirrhosis
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CONCLUSION. The ADCs in cirrhotic livers are significantly lower
than those in nonfibrotic livers. However, ADC values measured using the
current generation of scanners are not reliable enough to replace liver biopsy
for staging hepatic fibrosis. (Source: American Journal of Roentgenology)
Source: American Journal of Roentgenology - November 20, 2009 Category: Radiology Authors: Sandrasegaran, K., Akisik, F. M., Lin, C., Tahir, B., Rajan, J., Saxena, R., Aisen, A. M. Tags: Gastrointestinal Imaging Source Type: journals
What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?
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The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals
Frequency of antibodies against the etiologic agents of acquired imunodeficiency syndrome, syphilis, hepatitis B and C, and Chagas' disease in patients with rheumatic diseases treated with anti-tumor necrosis factor
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CONCLUSION: The frequency of seropositivity for different infectious diseases in patients under anti-TNF therapy is low. Individuals with positive serology for hepatitis C deserve close attention. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Primary antiphospholipid syndrome and hepatitis B and C infections
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CONCLUSION: A small percentage of patients with primary APS had positive serology for hepatitis B and C, and all represented cases post-vaccine or serology scar. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 20, 2009 Category: Rheumatology Source Type: journals
Hepatitis C Virus Proteins Induce Lipogenesis and Defective Triglyceride Secretion in Transgenic Mice [Lipids and Lipoproteins: Metabolism, Regulation, and Signaling]
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In conclusion, transgenic mice expressing the HCV full-length polyprotein at low levels have decreased plasma triglyceride levels and develop hepatocellular steatosis in the same way as HCV-infected patients. In these mice, SREBP1c activation by one or several HCV proteins induces de novo triglyceride synthesis via the lipogenic pathway, in a manner independent of ER stress, whereas triglyceride secretion is simultaneously reduced. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - November 20, 2009 Category: Chemistry Authors: Lerat, H., Kammoun, H. L., Hainault, I., Merour, E., Higgs, M. R., Callens, C., Lemon, S. M., Foufelle, F., Pawlotsky, J.-M. Tags: Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Source Type: journals
Dynavax Completes Enrollment Of First Cohort Of Patients In Phase 1b Clinical Trial For Hepatitis B Therapy
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Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that enrollment has been completed for the first of three cohorts of patients receiving DV-601 hepatitis B therapy in a Phase 1b clinical trial. The safety profile of patients in the first cohort met pre-specified criteria for dose escalation and the second cohort has been opened for enrollment. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
Toward Explaining Why Hepatitis B Hits Men Harder Than Women
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
Toward Explaining Why Hepatitis B Hits Men Harder Than Women
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / hepatitis Source Type: news
Dynavax Completes Enrollment Of First Cohort Of Patients In Phase 1b Clinical Trial For Hepatitis B Therapy
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Dynavax Technologies Corporation (NASDAQ: DVAX) announced today that enrollment has been completed for the first of three cohorts of patients receiving DV-601 hepatitis B therapy in a Phase 1b clinical trial. The safety profile of patients in the first cohort met pre-specified criteria for dose escalation and the second cohort has been opened for enrollment. Dynavax expects to report top-line data from this trial in the second half of 2010. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / hepatitis Source Type: news
Alnylam Presents New Pre-clinical Data On ALN-VSP, An RNAi Therapeutic For The Treatment Of Liver Cancer
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Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
Alnylam Presents New Pre-clinical Data On ALN-VSP, An RNAi Therapeutic For The Treatment Of Liver Cancer
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Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced new pre-clinical data from its ALN-VSP program presented at the AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics International conference being held November 15 - 19, 2009 in Boston, Mass. ALN-VSP is an RNAi therapeutic currently in a Phase I clinical trial for the treatment of liver cancers, including hepatocellular carcinoma (HCC) and other solid tumors with liver involvement. (Source: Cancer / Oncology News From Medical News Today)
Source: Cancer / Oncology News From Medical News Today - November 20, 2009 Category: Cancer & Oncology Tags: Liver Disease / hepatitis Source Type: news
Why Hepatitis B Hits Men Harder Than Women
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
Why Hepatitis B Hits Men Harder Than Women
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Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 20, 2009 Category: Gastroenterology Tags: Liver Disease / hepatitis Source Type: news
Do we need an 'in-house' neutralization assay for confirmation of hepatitis B surface antigen? Answers from a tertiary care hospital in India
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Conclusion: The enzyme immunoassay-based 'in-house' HBsAg neutralization assay is a feasible alternative to the commercial HBsAg confirmatory assay. This technique is easily adaptable, cost-effective and reliable for the confirmation of HBsAg in a low resource setting, enhancing the overall quality of HBsAg screening. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 20, 2009 Category: Gastroenterology Authors: Gnanadurai J Fletcher, Manu Gnanamony, Joel David, Ashrafali M Ismail, Thenmozhi Subramani, Priya Abraham Source Type: journals
Serum ferritin level changes in children with sickle cell disease on chronic blood transfusion are nonlinear and are associated with iron load and liver injury
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Chronic blood transfusion is increasingly indicated in patients with sickle cell disease. Measuring resulting iron overload remains a challenge. Children without viral hepatitis enrolled in 2 trials for stroke prevention were examined for iron overload (STOP and STOP2; n = 271). Most received desferrioxamine chelation. Serum ferritin (SF) changes appeared nonlinear compared with prechelation estimated transfusion iron load (TIL) or with liver iron concentrations (LICs). Averaged correlation coefficient between SF and TIL (patients/observations, 26 of 164) was r = 0.70; between SF and LIC (patients/observations, 33 of 47) w...
Source: Blood - November 19, 2009 Category: Hematology Authors: Adamkiewicz, T. V., Abboud, M. R., Paley, C., Olivieri, N., Kirby-Allen, M., Vichinsky, E., Casella, J. F., Alvarez, O. A., Barredo, J. C., Lee, M. T., Iyer, R. V., Kutlar, A., McKie, K. M., McKie, V., Odo, N., Gee, B., Kwiatkowski, J. L., Woods, G. M., C Tags: Free Research Articles, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: journals
Multitasking may be Achilles heel for hepatitis C
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Hepatitis C, a formidable virus that affects 130 million people worldwide, is nursing some pretty impressive bruises. By knocking out sections and subsections of one of its proteins, scientists reveal weak spots in the viruss armor and gain new momentum for developing drug targets for sufferers of the disease. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 19, 2009 Category: Biomedical Science Source Type: organizations
Is Hepatic Differentiation Of Embryonic Stem Cells Induced By Valproic Acid And Cytokines?
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. There have been several protocols available for hepatic fate specification from ES cells, however, most of the protocols currently used result in low yield or purity of functional hepatocytes. (Source: Transplants / Organ Donations News From Medical News Today)
Source: Transplants / Organ Donations News From Medical News Today - November 19, 2009 Category: Transplant Surgery Tags: Liver Disease / hepatitis Source Type: news
Is Hepatic Differentiation Of Embryonic Stem Cells Induced By Valproic Acid And Cytokines?
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Embryonic stem (ES) cells, known for their capacity to proliferate indefinitely and differentiate into almost all types of cells including hepatocytes, have raised the hope of cellular replacement therapy for liver failure. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
The Antifibrotic Effects Of Green Tea
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Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
Unexplained Liver Hemorrhage After Metastasis Radiofrequency Ablation
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Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved. Although historically it was considered that liver metastases meant a very poor prognosis, today, due to improved systemic therapy, many patients will be candidates for local hepatic treatments such as surgery or less aggressive radiofrequency ablation. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: Colorectal Cancer Source Type: news
The Antifibrotic Effects Of Green Tea
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Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis. Hepatoprotective effects of green tea against carbon tetrachloride, cholestasis and alcohol induced liver fibrosis were reported in many studies. However, the hepatoprotective effect of green tea in dimethylnitrosamine (DMN)-induced models has not been studied. (Source: Liver Disease / Hepatitis News From Medical News Today)
Source: Liver Disease / Hepatitis News From Medical News Today - November 19, 2009 Category: Gastroenterology Tags: Liver Disease / hepatitis Source Type: news
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data Shows
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The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data Shows
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The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
DPRK develops reagent for diagnosis of hepatitis C virus antibody
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PYONGYANG, Nov. 19 (Xinhua) -- The Academy of Medical ... (Source: Xinhuanet Chinaview Health)
Source: Xinhuanet Chinaview Health - November 19, 2009 Category: Consumer Health News Tags: Health Source Type: news
Why hepatitis is harder on men?
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Researchers in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women. Their study has been published online in ACS' Journal of Proteome Research, a monthly publication........ (Source: Medicineworld.org: New Article Alert)
Source: Medicineworld.org: New Article Alert - November 19, 2009 Category: Consumer Health News Source Type: info
ENGERIX-B (Hepatitis B Vaccine (Recombinant)) Injection, Suspension [GlaxoSmithKline Biologicals SA]
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Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 19, 2009 Category: Drugs & Pharmacology Source Type: organizations
G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence.
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CONCLUSION: G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasing neutrophil count, prolonging treatment and leading to sustained virological response (SVR) rates comparable to non-neutropenic patients. It prevents the occurrence of de novo autoimmune hepatitis.
PMID: 19916175 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Lodato F, Azzaroli F, Tamè MR, Di Girolamo M, Buonfiglioli F, Mazzella N, Cecinato P, Roda E, Mazzella G Tags: World J Gastroenterol Source Type: journals
Hepatitis B markers and vaccination-induced protection rate among Albanian pregnant women in Greece.
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Hepatitis B has long been a serious public health problem both in Greece and in Albania. In the February 2009 issue of World Journal of Gastroenterology, Resuli et al presented the interesting epidemiological data concerning hepatitis B virus infection in Albania. The results of this study were discussed and several data from our similar research were provided.
PMID: 19916183 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - November 19, 2009 Category: Gastroenterology Authors: Elefsiniotis IS, Vezali E, Brokalaki H, Tsoumakas K Tags: World J Gastroenterol Source Type: journals
Evidence for the insufficient evaluation and undertreatment of chronic hepatitis B infection in a predominantly low-income and immigrant population
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Conclusions: After the diagnosis of HBV infection, few patients in our population received laboratory evaluation to determine eligibility for HBV treatment. Furthermore, only a small percentage received HBV treatment. Further research needs to be done to validate these findings in other populations and understand barriers to receiving HBV treatment. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - November 19, 2009 Category: Gastroenterology Authors: Chin W Jung, Jennifer Tan, Nelly Tan, Melissa N Kuo, Ashwin Ashok, Samantha J Eells, Loren G Miller Source Type: journals
What are 'true normal' liver stiffness values using FibroScan®?: a prospective study in healthy living liver and kidney donors in South Korea
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To identify the normal range of liver stiffness (LS) values by recruiting healthy living liver and kidney donors in South Korea. Liver stiffness measurement (LSM) was performed in 69 healthy living liver and kidney donors who were admitted for transplantation. None of the subjects suffered from diabetes mellitus, hypertension, hepatitis B virus infection, hepatitis C virus infection, heart dysfunction, liver dysfunction or metabolic syndrome. LSM failure rate was 2.7%. Among 12 liver donors (17.4%) with available liver histology, eight showed normal liver histology and four showed liver steatosis of (Source: Liver International)
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Seung Up Kim, Gi Hong Choi, Woong Kyu Han, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Jin Sub Choi, Seung Choul Yang, Eun Hee Choi, Sang Hoon Ahn, Kwang-Hyub Han, Chae Yoon Chon Source Type: journals
Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells
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This study aimed to investigate the paracrine effects of hepatocarcinoma cells on human HSC using a co-culture system. Huh7 or HepG2 cells, human hepatocarcinoma cell lines, were co-cultured with primary human HSC. Intracellular calcium mobilization, proliferation, migration, expression of pro-angiogenic and fibrogenic genes, smooth muscle [alpha]-actin ([alpha]-SMA) protein expression, inflammatory properties (nuclear factor kappa B activation and interleukin 8 secretion) and intracellular signalling pathways (AKT and ERK) were analysed in HSC. Culture of HSC with Huh7 cells for 24 h stimulated HSC proliferation, migratio...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Pau Sancho-Bru, Elena Juez, Montserrat Moreno, Valeria Khurdayan, Manuel Morales-Ruiz, Jordi Colmenero, Vicente Arroyo, David A. Brenner, Pere Ginès, Ramón Bataller Source Type: journals
Endotipsitis-persistent infection of transjugular intrahepatic portosystemic shunt: pathogenesis, clinical features and management
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Transjugular intrahepatic portosystemic shunt (TIPS) is in widespread use for the decompression of portal pressure. The entity of persistent TIPS infection, also known as 'endotipsitis' is a rare but serious complication of TIPS insertion. The exact definition of 'endotipsitis' is still debated, but involves persistent bacteremia and fever together with either shunt occlusion, or vegetation, or bacteremia in the presence of a patent shunt, when other sources of bacteremia have been ruled out. To date, approximately 40 cases of 'endotipsitis' have been described, with predominance for male and alcoholic hepatitis patients. ...
Source: Liver International - November 19, 2009 Category: Gastroenterology Authors: Meir Mizrahi, Tomer Adar, Daniel Shouval, Allan I. Bloom, Oren Shibolet Source Type: journals
Immunoadsorption apheresis and immunosuppressive drug therapy in the treatment of complicated HCV-related cryoglobulinemia
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The immunosuppressive drug therapy (IDT) is not always effective to avoid the development of complications in hepatitis C virus-related cryoglobulinemia (HCV-Cr). Removal of cryoglobulins by therapeutic plasmapheresis is currently accepted. In this randomized, parallel group study, 17 male and female patients aged 43-79 years, with complicated HCV-Cr, were submitted for 12 weeks (initial immunosuppressive therapy) to IDT ([alpha]-interferon, pegylated-interferon [alpha]-2a, cyclophosphamide, methylprednisolone, prednisone, cyclosporine, ribavirin, and melphalan). Then, they were randomly assigned to two parallel groups: A ...
Source: Journal of Clinical Apheresis - November 19, 2009 Category: Hematology Authors: Claudia Stefanutti, Antonio Vivenzio, Serafina Di Giacomo, Giancarlo Labbadia, Fabio Mazza, Giovanna D'Alessandri, Pietro M. Ferraro, Cesare Masala Source Type: journals
Introduction of human papillomavirus (HPV) vaccination in Belgium, 2007-2008
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This paper documents the progress of human papillomavirus (HPV) vaccine introduction in Belgium. Information on vaccine use is based on sales statistics and reimbursement claims. From November 2007 to November 2008, the National Institute for Health and Disability Insurance reimbursed the HPV vaccine for girls aged between 12-15 years. In December 2008, the age limit was extended to include girls up to the age of 18. In November 2008, the total number of HPV vaccines sold exceeded 530,000 doses. The number of vaccines reimbursed in Belgium, for the period November 2007-November 2008, corresponds to the amount required to f...
Source: Eurosurveillance latest news - November 19, 2009 Category: Infectious Diseases Source Type: journals
Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patients
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Kamphues C, Lotz K, Röcken C, Berg T, Eurich D, Pratschke J, Neuhaus P, Neumann UP. Chances and limitations of non-invasive tests in the assessment of liver fibrosis in liver transplant patients.Clin Transplant 2009 DOI:10.1111/j.1399-0012.2009.01152.x© 2009 John Wiley & Sons A/S.Abstract: Because fibrosis progression resulting in liver cirrhosis represents the main reason for graft lost in patients after liver transplantation, an early detection of liver fibrosis is crucial. In recent years, several non-invasive tests for the assessment of liver fibrosis have been developed. We prospectively assessed the stage of liver ...
Source: Clinical Transplantation - November 19, 2009 Category: Transplant Surgery Authors: Carsten Kamphues, Katharina Lotz, Christoph Röcken, Thomas Berg, Dennis Eurich, Johann Pratschke, Peter Neuhaus, Ulf P. Neumann Source Type: journals
An interesting case of adenoviral hepatitis in a cardiac transplant recipient
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We present a case of adenoviral infection of a nontransplanted organ in a solid organ transplant recipient. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - November 19, 2009 Category: Transplant Surgery Authors: A. Gupta, A. Philip, K. Ranga, J. Cappa, J. Dougherty, M. Lawlor Source Type: journals
Mortality and drug exposure in a 5-year cohort of patients with chronic liver disease.
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CONCLUSIONS: Drug exposure in general was not associated with higher mortality except for a few categories. Mortality in patients with chronic liver disease was high and is associated with simple laboratory values.
PMID: 19924579 [PubMed - as supplied by publisher] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - November 19, 2009 Category: Journals (General) Authors: Hug BL, Lipsitz SR, Seger DL, Karson AS, Wright SC, Bates DW Tags: Swiss Med Wkly Source Type: journals
Insulin resistance and geographical origin: major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4
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Conclusion:
Insulin resistance and geographical origin are major predictors of liver fibrosis and response to peginterferon and ribavirin in HCV-4 patients. Insulin resistance is frequently encountered in these patients, and correlated independently with serum HCV-RNA. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Moucari, R, Ripault, M-P, Martinot-Peignoux, M, Voitot, H, Cardoso, A-C, Stern, C, Boyer, N, Maylin, S, Nicolas-Chanoine, M-H, Vidaud, M, Valla, D, Bedossa, P, Marcellin, P Tags: Cirrhosis Hepatology Source Type: journals
A novel technique for selective NF-{kappa}B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion
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Conclusions:
NF-B inhibiting decoy oligodeoxynucleotide-loaded gelatin nanoparticles is a novel tool to selectively inhibit NF-B activation in Kupffer cells in vivo. Thus, liver injury can be reduced in experimental fulminant hepatitis, but increased at ischaemia–reperfusion. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Hoffmann, F, Sass, G, Zillies, J, Zahler, S, Tiegs, G, Hartkorn, A, Fuchs, S, Wagner, J, Winter, G, Coester, C, Gerbes, A L, Vollmar, A M Tags: Hepatology Source Type: journals
New aspects of an anti-tumour drug: sorafenib efficiently inhibits HCV replication
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Conclusion:
Our data demonstrate that the well-characterised anti-tumour drug sorafenib efficiently blocks HCV replication in vitro. This novel effect of sorafenib should be further explored as an antiviral strategy for patients with chronic HCV infection. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Himmelsbach, K, Sauter, D, Baumert, T F, Ludwig, L, Blum, H E, Hildt, E Tags: Hepatology Source Type: journals
Insulin resistance is associated with liver stiffness in HIV/HCV co-infected patients
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Conclusion:
IR is associated with LS in patients co-infected with HIV/HCV. (Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Merchante, N, Rivero, A, de los Santos-Gil, I, Merino, D, Marquez, M, Lopez-Ruz, M A, Rodriguez-Bano, J, del Valle, J, Camacho, A, Sanz-Sanz, J, Macias, J, Perez-Camacho, I, Gomez-Mateos, J, Moro, A, Pineda, J A Tags: Hepatology Source Type: journals
HIV/hepatitis C co-infection and hepatic fibrosis: looking beyond HIV-associated immune suppression; the contribution of hepatic steatosis and insulin resistance
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(Source: Gut)
Source: Gut - November 18, 2009 Category: Gastroenterology Authors: Bhagani, S. Tags: Commentaries Source Type: journals
Swine flu vaccine uptake
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Several newspapers have reported that pregnant women and other vulnerable people are refusing to have the swine flu vaccine. The Times reported that a poll of GPs found that only 46% of people who were offered the vaccine have accepted it, and one doctor estimated that only 5% of pregnant women have had it.
The news reports are based on a “snapshot” survey of 107 GPs. The survey asked how likely they were to hit the government’s target of vaccinating at least half of their patients who are under 65 and in high-risk groups this winter. GPs were also asked to estimate how many of the people who were offered the vacci...
Source: NHS News Feed - November 18, 2009 Category: Consumer Health News Tags: Swine flu Source Type: news
Genetic Predictors of Treatment-Induced Viral Clearance in Hepatitis C
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Drs. Dermot McGovern and Gil Melmed comment on a study published in Nature on the ability of an IL-28B polymorphism to predict sustained viral response to hepatitis C treatment. Medscape Genomic Medicine (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 18, 2009 Category: Gastroenterology Tags: Pathology & Lab Medicine Source Type: info
InterMune Shares Fall on Change in Hepatitis Study
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From Associated Press (November 17, 2009)
NEW YORK--Shares of InterMune Inc. fell Tuesday after the
biotechnology company said it would discontinue a high-dose of its
experimental Hepatitis C treatment in a study because of potential
liver... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2009 Category: Pharmaceuticals Source Type: news
Acetaminophen-Related Liver Damage May Be Prevented By Common Herbal Medicine
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A well-known Eastern medicine supplement may help avoid the most common cause of liver transplantation, according to a study by researchers at the Stanford University School of Medicine. The finding came as a surprise to the scientists, who used a number of advanced genetic and genomic techniques in mice to identify a molecular pathway that counters acetaminophen toxicity, which leads to liver failure. (Source: Genetics News From Medical News Today)
Source: Genetics News From Medical News Today - November 18, 2009 Category: Genetics & Stem Cells Tags: Liver Disease / hepatitis Source Type: news
Acetaminophen-Related Liver Damage May Be Prevented By Common Herbal Medicine
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A well-known Eastern medicine supplement may help avoid the most common cause of liver transplantation, according to a study by researchers at the Stanford University School of Medicine. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Liver Disease / hepatitis Source Type: news
