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Hepatoblastoma in a Patient with Sotos SyndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of hepatoblastoma that developed in a child with Sotos syndrome, an overgrowth syndrome with an increased risk of neoplasms. Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 16, 2009 Category: Pediatrics Authors: Motohiro Kato, Junko Takita, Kan Takahashi, Masakazu Mimaki, Yuyan Chen, Katsuyoshi Koh, Kohmei Ida, Akira Oka, Masashi Mizuguchi, Seishi Ogawa, Takashi Igarashi Tags: Clinical and Laboratory Observations Source Type: journals

Mixed hepatoblastoma and teratoma of the liver in a 3-year-old child: a unique combination and clinical challengeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe the diagnosis and clinical management of a large liver tumor in a 3-year-old child that displayed the features of both, conventional hepatoblastoma and malignant teratoma. Pathological assessment on a pre-operative bioptical specimen showed an immature teratoid tumor with no area of hepatoblastic differentiation present. Histological and immunhistological examination of the resected tumor specimen additionally showed tumor areas of very different differentiation pattern intermixed with each other, namely areas of hepatoblastoma-typical and neuroblastoma-like morphology as well a areas of rhadomy...
Source: Diagnostic Pathology - November 12, 2009 Category: Pathology Authors: Alexander MollAlexander KrenauerUta BierbachHolger TillWolfgang HirschIvo LeuschnerNicole SchmitzChristian WittekindThomas Aigner Source Type: journals

Cisplatin alone safe and effective for patients with standard-risk hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: HemOncToday.com)
Source: HemOncToday.com - October 22, 2009 Category: Cancer & Oncology Source Type: info

Doxorubicin doesn't add benefit in treatment of standard-risk hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: NEJM Area: News Cisplatin alone is as effective as cisplatin plus doxorubicin in children with standard-risk hepatoblastoma, according to a controlled trial. Hepatoblastoma is a rare (10-15 each year in the UK) liver tumour occurring in children and usually presenting before age 2. Standard treatment was cisplatin plus doxorubicin based on the results of a trial carried out in the early 1990's, however evidence then became available that the doxorubicin component may not be necessary. This multi-centre trial aimed to clarify whether cisplatin alone was equally effective. It involved patients ag...
Source: NeLM - Oncology - October 21, 2009 Category: Cancer & Oncology Source Type: organizations

Cisplatin Alone Effective in Children With HepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cisplatin alone is just as effective as, but less toxic than, cisplatin plus doxorubicin in children with standard-risk hepatoblastoma, according to a study in the Oct. 22 issue of the New England Journal of Medicine. (Source: Modern Medicine)
Source: Modern Medicine - October 20, 2009 Category: Journals (General) Source Type: info

Cisplatin versus Cisplatin plus Doxorubicin for Standard-Risk HepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this randomized trial involving children with standard-risk hepatoblastoma, treatment with cisplatin alone caused fewer adverse events and achieved rates of complete resection and survival that were similar to rates achieved with treatment with cisplatin plus doxorubicin. These findings suggest that doxorubicin is not needed in treating children with hepatoblastoma who are not at high risk for a poor outcome. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 20, 2009 Category: Internal Medicine Authors: Perilongo, G., Maibach, R., Shafford, E., Brugieres, L., Brock, P., Morland, B., de Camargo, B., Zsiros, J., Roebuck, D., Zimmermann, A., Aronson, D., Childs, M., Widing, E., Laithier, V., Plaschkes, J., Pritchard, J., Scopinaro, M., MacKinlay, G., Czaude Tags: ORIGINAL ARTICLES Source Type: journals

Pim-2 Activates API-5 to Inhibit the Apoptosis of Hepatocellular Carcinoma Cells Through NF-kappaB Pathway.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pim-2 is proved to be relevant to the tumorigenesis of hepatocellular carcinoma (HCC), but the mechanism is unclear. We studied the relationship among Pim-2, NF-kappaB and API-5. In our experiment, expression level of the three factors and phosphorylation level of API-5, as well as NF-kappaB activity, were detected in HCC tissues and the nontumorous controls. Then Pim-2 gene was transfected into nontumorous liver cells L02, and Pim-2 SiRNA was transfected into hepatoblastoma cell line HepG2. Parthenolide was added as NF-kappaB inhibitor. The same detections as above were repeated in the cells, along with the apoptosis ...
Source: Pathology Oncology Research - October 11, 2009 Category: Pathology Authors: Ren K, Zhang W, Shi Y, Gong J Tags: Pathol Oncol Res Source Type: journals

Hepatoblastoma, cisplatin, and ototoxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Young infants with hepatoblastoma now have an excellent chance of cure, but many will be left with significant cisplatin-related hearing loss, which may impair their language and social development and may affect later learning with a lifetime of hearing loss. A report from the Children's Oncology Group of a randomized trial of amifostine for the prevention of platinum-related toxicity in infants with hepatoblastoma demonstrated that amifostine has no benefit in reducing cisplatin ototoxicity. Several new agents, such as sodium thiosulfate, currently are entering clinical trials as otoprotectants; however, as the goal for ...
Source: Cancer - October 8, 2009 Category: Cancer & Oncology Authors: Michael J. Sullivan Source Type: journals

Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The current study was conducted to determine whether amifostine is effective in reducing the toxicities associated with the administration of platinum-containing regimens in children with hepatoblastoma (HB).Patients were enrolled on P9645 beginning in March of 1999. Patients who had stage I/II disease received treatment with 4 cycles of combined cisplatin, 5-fluorouracil, and vincristine (C5V) with or without amifostine. Patients who had stage III/IV disease were randomized to receive treatment with 6 cycles of either C5V with or without amifostine or carboplatin alternating with cisplatin (CC) with or without amifostine....
Source: Cancer - October 6, 2009 Category: Cancer & Oncology Authors: Howard M. Katzenstein, Kay W. Chang, Mark Krailo, Zhengjia Chen, Milton J. Finegold, Jon Rowland, Marleta Reynolds, Alberto Pappo, Wendy B. London, Marcio Malogolowkin, for the Children's Oncology Group Source Type: journals

Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our results suggest that a chemotherapeutic regimen containing both AAP and CDDP with delayed NAC rescue has the potential to enhance chemotherapeutic efficacy while decreasing adverse effects. This would be a promising approach particularly for hepatoblastomas regardless of cellular CYP2E1 protein level but could also be beneficial in other malignancies. PMID: 19794959 [PubMed - in process] (Source: Neoplasia)
Source: Neoplasia - September 30, 2009 Category: Cancer & Oncology Authors: Neuwelt AJ, Wu YJ, Knap N, Losin M, Neuwelt EA, Pagel MA, Warmann S, Fuchs J, Czauderna P, Wozniak M Tags: Neoplasia Source Type: journals

RNAi-mediated silencing of insulin receptor substrate-4 enhances actinomycin D- and tumor necrosis factor-[alpha]-induced cell death in hepatocarcinoma cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Insulin receptor substrate-4 (IRS-4) transmits signals from the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR) to the PI3K/AKT and the ERK1/2 pathways. IRS-4 expression increases dramatically after partial hepatectomy and plays an important role in HepG2 hepatoblastoma cell line proliferation/differentiation. In human hepatocarcinoma, IRS-4 overexpression has been associated with tumor development. Herein, we describe the mechanism whereby IRS-4 depletion induced by RNA interference (siRNA) sensitizes HepG2 cells to treatment with actinomycin D (Act D) and combined treatment with Act D plus tumo...
Source: Journal of Cellular Biochemistry - September 29, 2009 Category: Biochemistry Authors: Eva P. Cuevas, Oscar Escribano, Jorge Monserrat, Javier Martínez-Botas, María G. Sánchez, Antonio Chiloeches, Borja Hernández-Breijo, Verónica Sánchez-Alonso, Irene D. Román, Ma Dolores Fernández-Moreno, Luis G. Guijarro Source Type: journals

Hepatic progenitor cells in liver cancers from Asian childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the two most common primary malignant liver tumours in children. Hepatic progenitor cells have been described and can be stained with K19, EpCAM and CD117. We investigated the morphology and staining patterns of primary liver tumours in Asian children. Four pathologists studied slides from 39 paediatric patients from Vietnam and Korea aged 8 months to 16 years. We performed immunohistochemical stains for K19, EpCAM and CD117, and polymerase chain reaction for tissue hepatitis B virus (HBV) DNA and hepatitis C virus (HCV) RNA. There was agreement on the diagnosis of...
Source: Liver International - September 28, 2009 Category: Gastroenterology Authors: Stephen C. Ward, Swan N. Thung, Kiat Hon Lim, Tung Thanh Tran, Thi Khang Bui Hong, Phuc Le Hoang, Ja June Jang, Young Nyun Park, Kenji Abe Source Type: journals

Cytogenetic and array comparative genomic hybridization analysis of a series of hepatoblastomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Hepatoblastoma is the most common primary hepatic tumor in children, and only a limited number of detailed karyotypic analyses have been reported to date. In the present study, cytogenetic abnormalities were identified in nine cases of hepatoblastoma from a single institution. Among characteristic chromosomal changes detected were simple numerical aberrations, structural alterations of chromosomes 1, 2, and 8, and the recurrent unbalanced rearrangements der(4)t(1;4)(q25.2;q35.1) and der(6)t(1;6)(q21;q26). Array comparative genomic hybridization was applied in four of the cases. The combined cytogenetic, molecular...
Source: Cancer Genetics and Cytogenetics - September 24, 2009 Category: Genetics & Stem Cells Authors: Eva Stejskalová, Josef Malis̆, Jiří S̆najdauf, Karel Pýcha, Helena Urbánková, Viera Bajciová, Jan Starý, Roman Kodet, Marie Jarošová Tags: Original articles Source Type: journals

Haptoglobin binds the antiatherogenic protein apolipoprotein E – impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Haptoglobin (Hpt) binds apolipoprotein A-I (ApoA-I), and impairs its stimulation of lecithin:cholesterol acyltransferase (LCAT). LCAT plays a major role in reverse cholesterol transport (RCT). Apolipoprotein E (ApoE), like ApoA-I, promotes different steps of RCT, including LCAT stimulation. ApoE contains amino acid sequences that are homologous with the ApoA-I region bound by Hpt and are involved in the interaction with LCAT. Therefore, Hpt was expected to also bind ApoE, and inhibit the ApoE stimulatory effect on LCAT. Western blotting and ELISA experiments demonstrated that the Hpt [beta]-subunit binds ApoE. The affinity...
Source: FEBS Journal - September 16, 2009 Category: Research Authors: Luisa Cigliano, Carmela R. Pugliese, Maria S. Spagnuolo, Rosanna Palumbo, Paolo Abrescia Source Type: journals

Hep G2 is a hepatoblastoma-derived cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatoblastoma (HB) is an embryonal malignancy of hepatocellular origin and the most common primary liver tumor of childhood, often presenting in the first years of life . Pediatric hepatocellular carcinoma is a rare tumor associated with much worse prognosis and aggressive behavior than HB and significantly less responsive to chemotherapy. It may occur as early as 1 year of age and in children may not be preceded by cirrhosis. Distinguishing between these tumors is sometimes difficult, especially in older children, so our laboratory is developing molecular genetic tests and has used the well-established cell line Hep G2 f...
Source: Human Pathology - September 14, 2009 Category: Pathology Authors: Dolores López-Terrada, Sau Wai Cheung, Milton J. Finegold, Barbara B. Knowles Tags: Correspondence Source Type: journals

SiRNA of Frizzled-9 suppresses proliferation and motility of hepatoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Frizzled (Fz), a receptor of Wnt ligands, plays key roles in liver carcinogenesis. Its expression was analyzed as part of a search for a target of molecular therapy for hepatocellular carcinoma (HCC) and hepatoblastoma (HB). Fz genes were analyzed by RT-PCR in HCC cell lines HLE, HLF, PLC/PRF/5, Huh-7 and Hep3B, HB cell lines Huh-6 and HepG2, HeLa cells, human normal fetal and adult liver. We transfected PLC/PRF/5, HLE, Huh-6, and HeLa cells with Fz9-small interfering RNA (Fz9-siRNA). Five days after transfection, cell proliferation was analyzed by MTS assay and cell motility by wound assay with H&E staining. Subse...
Source: International Journal of Oncology - September 4, 2009 Category: Cancer & Oncology Authors: Fujimoto T, Tomizawa M, Yokosuka O Tags: Int J Oncol Source Type: journals

Betulinic acid treatment promotes apoptosis in hepatoblastoma cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrate that BA is capable of inducing apoptosis in HB cells and thereby might be a hopeful new strategy for treating HB, especially those with an activated hedgehog signaling pathway. PMID: 19724925 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - September 4, 2009 Category: Cancer & Oncology Authors: Eichenmüller M, von Schweinitz D, Kappler R Tags: Int J Oncol Source Type: journals

Use of angioembolization as an effective technique for the management of pediatric solid tumorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Tumor angioembolization may enter the treatment algorithm for selected patients who have to face difficult or unwarranted surgical procedures or have diseases where conventional therapies have failed. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - August 31, 2009 Category: Surgery Authors: Lucas Krauel, Asteria Albert, Jaume Mora, Teresa Sola, Ofelia Cruz, Carlos Mortera, Josep María Ribó Tags: Operative Techniques Source Type: journals

Posttransplant Lymphoproliferative Disease in Pediatric Liver Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Posttransplant lymphoproliferative disease was first reported in 1968. Posttransplant lymphoproliferative disease encompasses a range of abnormalities from benign infectious mononucleosis-like illnesses to non-Hodgkin's lymphomas with nodal and extranodal site involvement. We evaluated five children who had posttransplant lymphoproliferative disease after liver transplantation. Since 2001, we have performed 118 liver transplantations in 115 children. Five children (4.6%), including three girls and two boys of overall mean age, 3.9 year, developed posttransplant lymphoproliferative diseases. The indications for li...
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: S. Sevmis, S. Pehlivan, R. Shabazov, H. Karakayali, F. Ozcay, M. Haberal Tags: Liver Transplantation Source Type: journals

Complete resection of hepatoblastoma originating in the caudate lobe: case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hepatoblastoma originating in the caudate lobe is extremely rare, and resection is technically challenging. The aim of this study was to report our experience of complete resection of hepatoblastoma originating in the caudate lobe and review the literature. A 12-month-old boy was admitted for investigation of an upper abdominal mass. Imaging studies showed an irregularly lobulated 8-cm solid tumor in the left lobe of the liver. Serum α-fetoprotein was 67,700 ng/mL. This tumor was diagnosed as hepatoblastoma (PRETEXT II) and chemotherapy (3 courses of CDDP and ADR) was performed. After chemothe...
Source: Pediatric Surgery International - August 21, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals

Altered microRNA Expression Patterns in Hepatoblastoma Patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, although our samples were poorly informative from a genetic point of view, they showed a peculiar microRNA expression pattern compared with nontumor tissues and hepatocellular carcinoma. MicroRNA could represent valid markers for the classification of pediatric liver tumors. PMID: 19701500 [PubMed - in process] (Source: Translational Oncology)
Source: Translational Oncology - August 17, 2009 Category: Cancer & Oncology Authors: Magrelli A, Azzalin G, Salvatore M, Viganotti M, Tosto F, Colombo T, Devito R, Di Masi A, Antoccia A, Lorenzetti S, Maranghi F, Mantovani A, Tanzarella C, Macino G, Taruscio D Tags: Transl Oncol Source Type: journals

JNK1 activation predicts the prognostic outcome of the human hepatocellular carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Accordingly, we believe that the H-JNK1 HCC may originate from hepatic progenitor cells and is associated with poorer prognosis. The status of JNK1 activation in HCC tissue, thus, might be a new biomarker for HCC prognosis and therapeutic targeting (Source: Molecular Cancer)
Source: Molecular Cancer - August 16, 2009 Category: Cancer & Oncology Authors: Qingshan ChangJianguo ChenKevin BeezholdVince CastranovaXianglin ShiFei Chen Source Type: journals

Evaluation of pediatric abdominal masses by fine-needle aspiration cytology: A clinicoradiologic approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathologist forms a very important part of the clinical team in the management of pediatric intra-abdominal masses in giving a rapid, accurate diagnosis for these potentially curable tumors. Fine-needle aspiration cytology (FNAC) is an invaluable tool in this regard when interpreted with clinicoradiologic parameters. With this in mind, we decided to evaluate the role of FNAC in pediatric abdominal masses in our institution. A total of 83 of 105 FNAC accessioned in the pathology department over 5 years (2003-2007) were studied. These included only cases where a diagnosis could be offered on cytology. Detailed clinicorad...
Source: Diagnostic Cytopathology - August 16, 2009 Category: Pathology Authors: Seethalakshmi Viswanathan, Sophia George, Mukta Ramadwar, Seema Medhi, Brijesh Arora, Purna Kurkure Source Type: journals

Sterol-mediated Regulation of Human Lipin 1 Gene Expression in Hepatoblastoma Cells [Lipids and Lipoproteins: Metabolism, Regulation, and Signaling]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have demonstrated that lipin 1 gene (LPIN1) expression is regulated by cellular sterols, which are key regulators of lipid metabolism. We have also characterized the sterol-response element and nuclear factor Y-binding sites in the human LPIN1 promoter. Using a luciferase assay, electrophoretic mobility shift assay, and chromatin immunoprecipitation assay, we demonstrated that these elements are responsible for the transcription of LPIN1 gene, mediated by SREBP-1 (sterol regulatory element-binding protein 1) and nuclear factor Y. Furthermore, we investigated whether lipin 1 is involved in lipogenesis by t...
Source: Journal of Biological Chemistry - August 6, 2009 Category: Chemistry Authors: Ishimoto, K., Nakamura, H., Tachibana, K., Yamasaki, D., Ota, A., Hirano, K.-i., Tanaka, T., Hamakubo, T., Sakai, J., Kodama, T., Doi, T. Tags: Lipids and Lipoproteins: Metabolism, Regulation, and Signaling Source Type: journals

Emerging gene-directed anti-tumor strategies against human hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Expert Opinion on Biological Therapy , September 2009, Vol. 9, No. 9, Pages 1155-1161. (Source: Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents)
Source: Expert Opinion: Expert Opinion on Biological Therapy: Table of Contents - August 5, 2009 Category: Drugs & Pharmacology Tags: article Source Type: journals

Loss of carcinoembryonic antigen-related cell adhesion molecule 1 expression predicts metachronous pulmonary metastasis and poor survival in patients with hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Loss of CEACAM1 expression may reflect a high metastatic potential and thus indicate a poor prognosis for patients with hepatoblastoma. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - July 28, 2009 Category: Surgery Authors: Mami Tsukada, Toshifumi Wakai, Yasunobu Matsuda, Pavel V. Korita, Yoshio Shirai, Yoichi Ajioka, Katsuyoshi Hatakeyama, Masayuki Kubota Tags: Original Articles Source Type: journals

Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatoblastoma is a rare malignancy of childhood. The scarcity of adequate cell models has limited our understanding of this tumor. Here we describe and characterize a new human liver tumor cell line, Hep293TT, derived from an aggressive childhood hepatoblastoma.Hep293TT cells were established using primary tumor tissues from a 5-year-old Caucasian female child. This cell line has been maintained for more than 34 months and over 20 subcultures, and was characterized by histopathology, ELISA, genotype, cytogenetics, CGH array, immunohistochemistry, and molecular sequence analyses.Cells were confirmed to originate from paren...
Source: Pediatric Blood and Cancer - July 26, 2009 Category: Cancer & Oncology Authors: Tina T.-L. Chen, Dinesh Rakheja, Jaclyn Y. Hung, Peter J. Hornsby, Piotr Tabaczewski, Marcio Malogolowkin, James Feusner, Frank Miskevich, Roger Schultz, Gail E. Tomlinson Source Type: journals

Global proteome analysis of hepatitis B virus expressing human hepatoblastoma cell line HepG2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study described the proteomic alterations in HepG2 cells HBV-harboring, which may provide new insights into the underlying molecular mechanisms involved in HBV replication and pathogenesis. J. Med. Virol. 81:1539-1550, 2009. © 2009 Wiley-Liss, Inc. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - July 21, 2009 Category: Virology Authors: Qingling Huang, Lin Wang, Shiyu Bai, Wansong Lin, Wannan Chen, Jianyin Lin, Xu Lin Tags: Research Article Source Type: journals

Experience with hemihyperplasia and Beckwith-Wiedemann syndrome surveillance protocolEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, ultrasound surveillance detected renal and liver pathology including benign and malignant lesions. The known variability of AFP in normal neonates and patients with BWS makes interpretation difficult in early infancy. Very high AFP values did seem to be correlated with risk for identifiable liver lesions. Determination of the natural changes in AFP levels over time will allow more appropriate comparison. © 2009 Wiley-Liss, Inc. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - July 15, 2009 Category: Genetics & Stem Cells Authors: Yuri A. Zarate, Rafael Mena, Lisa J. Martin, Paul Steele, Bradley T. Tinkle, Robert J. Hopkin Source Type: journals

Aicardi syndrome associated with hepatoblastoma and pulmonary sequestrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - July 15, 2009 Category: Genetics & Stem Cells Authors: Benjamin Aaron Kamien, Michael Terrence Gabbett Source Type: journals

Predictive power of pretreatment prognostic factors in children with hepatoblastoma: A report from the Children's Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PRETEXT is used to stratify risk in children with hepatoblastoma by the Liver Tumor Strategy Group (SIOPEL) of the International Society of Pediatric Oncology (SIOP). A recent analysis excluding patients that did not survive neoadjuvant chemotherapy, concluded that PRETEXT was superior to Children's Oncology Group (COG) stage for predicting survival. Puzzled by this result, we made a similar comparison of PRETEXT and COG stage. This time, however, we include all patients, and we compare predictive value at diagnosis, instead of after neoadjuvant chemotherapy.Hepatoblastoma patients in INT-0098 were retrospectively reviewed...
Source: Pediatric Blood and Cancer - July 7, 2009 Category: Cancer & Oncology Authors: Rebecka L. Meyers, Jon R. Rowland, Mark Krailo, Zhengjia Chen, Howard M. Katzenstein, Marcio H. Malogolowkin Source Type: journals

Activation of Phosphatidylinositol-3'-kinase/AKT Signaling Is Essential in Hepatoblastoma Survival.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings imply that PI3K signaling plays an essential role in growth control of hepatoblastoma and might be successfully targeted in multimodal therapeutic strategies. PMID: 19584164 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - July 6, 2009 Category: Cancer & Oncology Authors: Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, Czerwitzki J, Metzger D, Steiner S, Wurst P, Leuschner I, von Schweinitz D, Buettner R, Pietsch T Tags: Clin Cancer Res Source Type: journals

cis-Clerodane Diterpenoids from the Liverwort Gottschelia schizopleura and their Cytotoxic ActivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Planta MedDOI: 10.1055/s-0029-1185837AbstractTwo new and three previously known -clerodane diterpenoids were isolated from the wild liverwort (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds – were evaluated against liver hepatoblastoma (HEP‐G2), lung carcinoma (A549), breast ductal carcinoma (MDA‐MB‐435), and colon adenocarcinoma (LOVO) cell lines. Compound showed moderate inhibition against MDA‐MB‐435 and LOVO cells.[...]© Georg Thieme Verlag KG Stuttgart ...
Source: Planta Medica - July 5, 2009 Category: Drugs & Pharmacology Tags: Original Paper Source Type: journals

Cancer risk among children with very low birth weights.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. PMID: 19564288 [PubMed - in process] (Source: Cancer Control)
Source: Cancer Control - June 30, 2009 Category: Cancer & Oncology Authors: Spector LG, Puumala SE, Carozza SE, Chow EJ, Fox EE, Horel S, Johnson KJ, McLaughlin CC, Reynolds P, Behren JV, Mueller BA Tags: Pediatrics Source Type: journals

Cancer Risk Among Children With Very Low Birth WeightsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggested no association between most cancers and very low birth weight, with the exception of the known association of hepatoblastoma and possibly moderately increased risks of other gliomas and retinoblastoma, which may warrant confirmation. (Source: PEDIATRICS)
Source: PEDIATRICS - June 28, 2009 Category: Pediatrics Authors: Spector, L. G., Puumala, S. E., Carozza, S. E., Chow, E. J., Fox, E. E., Horel, S., Johnson, K. J., McLaughlin, C. C., Reynolds, P., Behren, J. V., Mueller, B. A. Tags: Premature & Newborn ARTICLES Source Type: journals

Autologous peripheral blood stem-cell transplantation with a double-conditioning regimen for recurrent hepatoblastoma after liver transplantation – A valid therapeutic option or just too much? – Author replyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Pediatric Transplantation)
Source: Pediatric Transplantation - June 28, 2009 Category: Transplant Surgery Authors: Katsutsugu Umeda, Ken-Ichiro Watanabe Source Type: journals

The Role of Pediatricians in Families with a History of Familial Adenomatous PolyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Colon cancer is not an entity that pediatricians routinely confront; however, a family history of colon cancer can have pediatric implications when it is part of familial adenomatous polyposis syndrome. Colonic (multiple intestinal polyps) and extracolonic manifestations (such as hepatoblastoma or brain tumors) can be the presenting features in children. The authors present 2 patients from different families with familial adenomatous polyposis who presented with the extracolonic manifestation of this syndrome and a family history of colon cancer. Identification of these families and education of their primary care givers c...
Source: Clinical Pediatrics - June 4, 2009 Category: Pediatrics Authors: Augustyn, A. M., Wallerstein, R. Tags: Article Source Type: journals

Living donor liver transplantation for hepatoblastoma with Beckwith–Wiedemann syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of BWS in a girl with unresectable hepatoblastoma, who received a planned LVDT following neo-adjuvant chemotherapy. This is the first case report of liver transplantation for patients with BWS. Tumor surveillance after transplantation would be necessary to detect possible recurrence of the original disease and development of other malignancies. (Source: Pediatric Transplantation)
Source: Pediatric Transplantation - June 1, 2009 Category: Transplant Surgery Authors: Kazunari Sasaki, Mureo Kasahara, Akinari Fukuda, Takanobu Shigeta, Hideaki Tanaka, Satoshi Nakagawa, Kazumasa Mitsui, Ryoko Harada, Atsuko Nakagawa Source Type: journals

Upstream reactive oxidative species (ROS) signals in exogenous oxidative stress-induced mitochondrial dysfunction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exogenous oxidative stress induces cell death, but the upstream molecular mechanisms involved of the process remain relatively unknown. We determined the instant dynamic reactions of intracellular reactive oxygen species (ROS, including hydrogen peroxide (H(2)O(2)), superoxide radical (O(2)(*)(-)), and nitric oxide (NO)) in cells exposed to exogenous oxidative stress by using a confocal laser scanning microscope. Stimulation with extracellular H(2)O(2) significantly increased the production of intracellular H(2)O(2), O(2)(*)(-), and NO (P<0.01) through certain mechanisms. Increased levels of intracellular ROS result...
Source: Cell Biology International - May 31, 2009 Category: Cytology Authors: Lu M, Gong X Tags: Cell Biol Int Source Type: journals

Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we examined whether Dkk3 was related to a premature or dedifferentiated nature in hepatoblastomas (HBLs) and hepatocellular carcinomas (HCCs). It was demonstrated that Dkk3 was overexpressed in HBLs and HCCs and that its expression was more frequent in the former than in the latter, being consistent with the fact that most HBLs show an embryonal or fetal hepatic histology, whereas there was no distinct relationship between Dkk3 expression and clinical data or histology. All of the HBLs expressed Dkk3, alpha-fetoprotein (AFP), or both proteins, suggesting that, similar to AFP, Dkk3 is another potentially...
Source: Virchows Archiv - May 13, 2009 Category: Pathology Tags: Virchows Archiv Source Type: journals

Surgical Management of Giant Liver Tumor Involving the Hepatic Hilum of ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Resecting giant liver tumors involving the main hepatic veins and/or the retrohepatic vena cava, although challenging, is feasible and safe. Content Type Journal ArticleDOI 10.1007/s00268-009-0060-0Authors Qian Dong, Qing Dao University Department of Pediatric Surgery, The Affiliated Hospital of Medical College 16 Jiangsu Road Qing Dao City 266003 ChinaBuxian Jiang, Qing Dao University Department of Pediatric Surgery, The Affiliated Hospital of Medical College 16 Jiangsu Road Qing Dao City 266003 ChinaYun Lu, Qing Dao University Second Department of General Surgery, The Affiliated Hospital ...
Source: World Journal of Surgery - May 8, 2009 Category: Surgery Tags: World Journal of Surgery Source Type: journals

Modulation of morphology and functions of human hepatoblastoma cells by nano-grooved substrataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the impact of nano-grooves/ridges on hepatocyte morphology and functions. HepG2/C3A (C3A) cells were cultured on nano-grooved silicon or polystyrene substrata with various widths (from 100 to 500nm) and depths (from 100 to 380nm). Nano-grooved substrates induced dramatic changes in C3A cell morphology. The cells formed spheroids on the flat substrates, while C3A cells spread and grew confluently with elongated and aligned morphology along the nano-grooves/ridges. Albumin synthesis was enhanced on the nano-grooved silicon substrates compared to the flat surface, and was decreased with increasi...
Source: Acta Biomaterialia - May 5, 2009 Category: Materials Science Authors: Wei-Bor Tsai, Jia-Hua Lin Source Type: journals

Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Farnesoid X receptor (FXR) is a bile acid-sensing nuclear receptor that controls bile acid homeostasis. It has been suggested that downregulation of FXR contributes to the pathogenesis of an inherited disorder of bile secretion caused by mutations in ATP8B1. We have investigated the relationship between ATP8B1 knockdown and FXR downregulation in the human hepatoblastoma cell line HepG2. Transfection of HepG2 cells with ATP8B1 small interfering RNA (siRNA) duplexes led to a 60% reduction in the endogenous levels of ATP8B1 mRNA and protein and a concomitant decrease in FXR mRNA and protein content, as well as in FXR phosphor...
Source: AJP: Gastrointestinal and Liver Physiology - April 24, 2009 Category: Gastroenterology Authors: Martinez-Fernandez, P., Hierro, L., Jara, P., Alvarez, L. Tags: LIVER AND BILIARY TRACT Source Type: journals

Absence of oncogenic AKT1 E17K mutation in prostate, esophageal, laryngeal and urothelial carcinomas, hepatoblastomas, gastrointestinal stromal tumors and malignant meningiomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19353338 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - April 6, 2009 Category: Cancer & Oncology Authors: Eom HS, Kim MS, Hur SY, Yoo NJ, Lee SH Tags: Acta Oncol Source Type: journals

Synergistic Effect of Radiation and Interleukin-6 on Hepatitis B Virus Reactivation in Liver Through STAT3 Signaling PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: RT to the liver and longer sustained IL-6 induced HBV reactivation through the STAT3 signal transduction pathway. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 27, 2009 Category: Radiology Authors: Chia Hung Chou, Pei-Jer Chen, Yung-Ming Jeng, Ann-Lii Cheng, Li-Rung Huang, Jason Chia-Hsien Cheng Tags: Biology Contributions Source Type: journals

Gastrointestinal stromal tumor of the lesser omentum in a young adult patient with a history of hepatoblastoma: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a case of GIST of the lesser omentum in a 22-year-old man with a history of hepatoblastoma. Computed tomography showed an abdominal mass about 30 mm in diameter adjacent to the lesser wall of the stomach. A laparotomy showed a mass of about 27 × 24 × 20 mm in diameter originating from the lesser omentum but isolated from the stomach and the liver. Histopathology showed that the tumor was composed of spindle-shaped tumor cells with high cellularity. Immunohistochemically, the tumor was positive for KIT and CD34. An in-frame deletion was observed in the c-kit gene exon 11. Therefore, the tumor was...
Source: Surgery Today - March 25, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides novel insights about the role played by CAV1 in modulating cellular sensitivity to RES through enhancement of its internalization and trafficking. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - March 25, 2009 Category: Research Authors: Hui-ling Yang, Wei-qiong Chen, Xuan Cao, Andrea Worschech, Li-fen Du, Wei-yi Fang, Yang-yan Xu, David F Stroncek, Xin Li, Ena Wang and Francesco M Marincola Source Type: journals

Caveolin-1 enhances resveratrol-mediated cytotoxicity and transport in a hepatocellular carcinoma model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides novel insights about the role played by CAV1 in modulating cellular sensitivity to RES through enhancement of its internalization and trafficking. PMID: 19321006 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - March 25, 2009 Category: Cytology Authors: Yang HL, Chen WQ, Cao X, Worschech A, Du LF, Fang WY, Xu YY, Stroncek DF, Li X, Wang E, Marincola FM Tags: J Transl Med Source Type: journals

Survival trends in children with hepatoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Hepatoblastoma continues to challenge surgeons and oncologists. Most children are diagnosed early in life and undergo surgical resection whenever possible. With the advent of efficacious chemotherapy, survival has improved. Older children, black patients, and those who present with advanced disease tend to have poor outcomes. Surgical resection is the single most important predictor of survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00383-009-2349-3Authors John D. Horton, William Beaumont Army Medical Center Department of Surgery 5005 North Piedras St. El Paso ...
Source: Pediatric Surgery International - March 24, 2009 Category: Surgery Tags: Pediatric Surgery International Source Type: journals

Regulation of expression of apolipoprotein A-I by selenium status in human liver hepatoblastoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that supplementation of hepatocytes with Se mitigates oxidative stress-dependent repression of apoA-I expression by suppressing the NF-κB pathway, which allows PPARα to effectively drive the expression of apoA-I. Content Type Journal ArticleCategory Original ContributionDOI 10.1007/s00394-009-0012-3Authors Jessica A. Stahle, The Pennsylvania State University Undergraduate Program in Animal Biosciences University Park PA USAHema Vunta, The Pennsylvania State University Graduate Program in Pathobiology, Department of Veterinary and Biomedical Sciences, Center for Molecula...
Source: European Journal of Nutrition - March 18, 2009 Category: Nutrition Tags: European Journal of Nutrition Source Type: journals