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This page shows you the latest news and research items in this category.

Progesterone may be why pregnant women are more vulnerable to certain infections
(Federation of American Societies for Experimental Biology) Women who are pregnant or using synthetic progesterone birth control injections have a vulnerability to infections including malaria, Listeria, HIV, and herpes simplex virus. Research in the Journal of Leukocyte Biology shows that the progesterone receptor, a pregnancy hormone sensor, targets a part of the immune system responsible for protection against these invaders. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 28, 2013 Category: Global & Universal Source Type: news

MIMR researchers find a protein link to STI susceptibility
(Monash Institute of Medical Research) Monash Institute of Medical Research scientists have found a protein in the female reproductive tract that protects against sexually transmitted diseases such as chlamydia and herpes simplex virus. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 28, 2013 Category: Global & Universal Source Type: news

Viable herpes simplex virus type 1 and varicella‐zoster virus in the trigeminal ganglia of human cadavers
Abstract Human herpes simplex virus type 1 (HSV‐1) and varicella‐zoster virus (VZV) were isolated in the bilateral trigeminal ganglia of 12 human cadavers with no history of herpes‐related symptoms within 1–5 days of death. Sixteen trigeminal ganglia were subjected to explant culture by using Vero cells, but no cytopathogenic effects (CPE) were observed. However, when another eight trigeminal ganglia were placed in a cell strainer and kept from direct contact with Vero cells during culture, CPE were clearly apparent in all cultures. The amount of DNA in the culture supernatants of 16 trigeminal ganglia decreased ov...
Source: Journal of Medical Virology - February 27, 2013 Category: Virology Authors: Hisako Saitoh, Yuko Momma, Hiroyuki Inoue, Daisuke Yajima, Hirotaro Iwase Tags: Research Article Source Type: research

Short flap rhytidectomy and fractional CO2 laser rejuvenation of the aging face
ConclusionsCombination fractional laser resurfacing with short flap, high‐Superficial muscular aponeurotic system rhytidectomy is a safe procedure with excellent patient satisfaction and clinical outcomes. (Source: Journal of Cosmetic Dermatology)
Source: Journal of Cosmetic Dermatology - February 26, 2013 Category: Dermatology Authors: Farhan Taghizadeh, Alicia Leibowitz, Timothy Ellison, Michael Griego, Mimi Traylor‐Knowles, Patrick Ramirez Tags: Original Contribution Source Type: research

Glycoprotein targeted therapeutics: a new era of anti‐herpes simplex virus‐1 therapeutics
SUMMARY Herpes simplex virus type‐1 (HSV‐1) is among the most common human pathogens worldwide. Its entry into host cells is an intricate process that relies heavily on the ability of the viral glycoproteins to bind host cellular proteins and to efficiently mediate fusion of the virus envelope with the cell membrane. Acquisition of HSV‐1 results in a lifelong latent infection. Because of the cycles of reactivation from a latent state, much emphasis has been placed on the management of infection through the use of DNA synthesis inhibitors. However, new methods are needed to provide more effective treatment at earlier ...
Source: Reviews in Medical Virology - February 26, 2013 Category: Virology Authors: Thessicar E. Antoine, Paul J. Park, Deepak Shukla Tags: Review Source Type: research

Gastrointestinal: Herpes vasculitis in an ulcerative colitis patient
(Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - February 26, 2013 Category: Gastroenterology Authors: J‐M Wong, P‐H Huang, S‐Ch Wei Tags: Education and Imaging Source Type: research

Increased Risk of Herpes Zoster in Patients With IBDIncreased Risk of Herpes Zoster in Patients With IBD
This new study explores the reasons why some patients with IBD may develop herpes zoster. Are certain medications to blame? Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

The Safety and Efficacy of KAI‐1678— An Inhibitor of Epsilon Protein Kinase C (εPKC)—Versus Lidocaine and Placebo for the Treatment of Postherpetic Neuralgia: A Crossover Study Design
Conclusions.We conclude that KAI‐1678 is not efficacious as an acute analgesic for chronic neuropathic pain because of PHN. However, for the first time, the results demonstrate that subcutaneous infusions of lidocaine are effective in treating neuropathic pain. The results of lidocaine treatment also indicate that the crossover study design was adequate to detect a clinically meaningful response in this analgesia study. (Source: Pain Medicine)
Source: Pain Medicine - February 25, 2013 Category: Anesthesiology Authors: Michael J. Cousins, Karen Pickthorn, Saling Huang, Linda Critchley, Gregory Bell Tags: Original Article Source Type: research

Impact of antigen specificity on CD4+ T cell activation in chronic HIV-1 infection: CD4+ specificity and activation in HIV
Activation levels of herpes virus-specific CD4+ T cell populations are significantly elevated in untreated HIV+ individuals, suggesting that the elevated level of immune activation that characterizes chronic HIV infection may be influenced by the persistence of other antigens (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 25, 2013 Category: Infectious Diseases Authors: Miranda SmithSonia BastidasUrs KarrerAnnette Oxenius Source Type: research

Isolated ocular flutter
A previously healthy 30-year-old man presented with gradually worsening oscillopsia 2 weeks after an unusual headache; there was ocular flutter on examination (video on the Neurology® Web site at www.neurology.org) without other findings. Brain MRI was unremarkable. CSF showed mild pleocytosis (11 cells/mm3), but no evidence of active viral infections (herpes simplex virus, cytomegalovirus, varicella-zoster virus, Epstein-Barr virus, human herpesvirus 6, and measles). Serum antiganglioside antibodies (including anti-GQ1b antibody) were negative. The symptom resolved without treatment within 4 weeks. Ocular flutter is r...
Source: Neurology - February 25, 2013 Category: Neurology Authors: Nasu, S., Uzawa, A., Mori, M., Kuwabara, S. Tags: All Clinical Neurology, All Movement Disorders, Oscillopsia VIDEO NEUROIMAGES Source Type: research

Therapeutic low-intensity red laser for herpes labialis on plasmid survival and bacterial transformation
, 2013, Accepted ManuscriptDOI: 10.1039/C3PP25394E, PaperLuiz Philippe Silva Sergio, Roberta Silva Marciano, Gleica Rocha Teixeira, Keila Silva Canuto, Giovanni Augusto Castanheira Polignano, Oscar Roberto Guimaraes, Mauro Geller, Flavia Paoli, Adenilson Souza FonsecaLow-intensity laser is used in treating herpes labialis based on biostimulative effect, albeit the photobiological basis is not well understood. In this work experimental models based on Escherichia coli cultures...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Photochem. Photobiol. Sci. latest articles)
Source: RSC - Photochem. Photobiol. Sci. latest articles - February 22, 2013 Category: Chemistry Authors: Luiz Philippe Silva Sergio Source Type: research

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit
Terminases are enzymes that are required for the insertion of a single viral genome into the interior of a viral procapsid by a process referred to as `encapsulation or packaging'. Many double-stranded DNA viruses such as bacteriophages T3, T4, T7, λ and SPP1, as well as herpes viruses, utilize terminase enzymes for this purpose. All the terminase enzymes described to date require two subunits, a small subunit referred to as TerS and a large subunit referred to as TerL, for in vivo activity. The TerS and TerL subunits interact with each other to form a functional hetero-oligomeric enzyme complex; however the stoichiometry...
Source: Acta Crystallographica Section F - February 22, 2013 Category: Biochemistry Authors: Ren, B.Pham, T.M.Surjadi, R.Robinson, C.P.Le, T.Chandry, P.S.Peat, T.S.McKinstry, W.J. Tags: small terminase subunit DNA-binding protein Siphoviridae bacteriophage crystallization communications Source Type: research

Plantar leukocytoclastic vasculitis with detection of herpes simplex virus type 2 by PCR assay
(Source: International Journal of Dermatology)
Source: International Journal of Dermatology - February 22, 2013 Category: Dermatology Authors: Yoo Sang Baek, Won Ung Shin, Hae Jun Song, Chil Hwan Oh, Soobin Son Tags: Correspondence Source Type: research

Prevalence of viruses in stool of premature neonates at a neonatal intensive care unit
ConclusionThe overall viral detection rate in stool of 5.7% (affecting 17% of neonates) indicates viral infections are an important health risk for premature infants in NICU. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - February 22, 2013 Category: Pediatrics Authors: Zin Naing, Benjamin Rayner, Ananthen Killikulangara, Krishna Vunnam, Steven Leach, Christopher J McIver, Gillian M Scott, Maria E Craig, Kei Lui, William D Rawlinson Tags: Original Article Source Type: research

The estimated direct medical cost of selected sexually transmitted infections in the United States, 2008.
CONCLUSIONS: Sexually transmitted infections continue to impose a substantial cost burden on the payers of medical care in the United States. The burden of STIs would be even greater in the absence of STI prevention and control efforts. PMID: 23403600 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Owusu-Edusei K, Chesson HW, Gift TL, Tao G, Mahajan R, Ocfemia MC, Kent CK Tags: Sex Transm Dis Source Type: research

Sexually Transmitted Infections Among US Women and Men: Prevalence and Incidence Estimates, 2008.
CONCLUSIONS: Sexually transmitted infections are common in the United States, with a disproportionate burden among young adolescents and adults. Public health efforts to address STIs should focus on prevention among at-risk populations to reduce the number and impact of STIs. PMID: 23403598 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Satterwhite CL, Torrone E, Meites E, Dunne EF, Mahajan R, Ocfemia MC, Su J, Xu F, Weinstock H Tags: Sex Transm Dis Source Type: research

Herpes simplex virus infection and erectile dysfunction: a nationwide population-based study.
In conclusion, HSV infections were associated with risk of ED in this cohort. PMID: 23413136 [PubMed - in process] (Source: Herpes)
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Huang CC, Chan WL, Chen YC, Chen TJ, Chung CM, Huang PH, Lin SJ, Chen JW, Leu HB Tags: Andrology Source Type: research

Intrahost genetic variability of human herpes virus-8.
Abstract Studies were conducted to determine whether HHV-8 hyperactivity could be the consequence of the propensity of the host to multiple HHV-8 infection. The aim of the present work was to investigate HHV-8 intrahost genetic variability. HHV-8 subgenomic DNA was amplified by PCR from patients infected with HIV, health care workers (HCW) and bone marrow transplant recipients (BMT), and from oral lesional tissues of AIDS-Kaposi's sarcoma (KS) patients. As controls, blood from HIV-negative health care workers, and the cell lines BC-1, BC-2, and BCP-1 were used. Clones derived from amplicons originating from DNA fra...
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Leao JC, de Faria AB, Fonseca DD, Gueiros LA, Silva IH, Porter SR Tags: J Med Virol Source Type: research

Cellular MicroRNAs 498 and 320d Regulate Herpes Simplex Virus 1 Induction of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Targeting RTA.
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) infection was necessary but not sufficient for KS development without other cofactors. We have previously reported that herpes simplex virus (HSV)-1 was an important cofactor that reactivated KSHV from latency by inducing the expression of KSHV replication and transcription activator (RTA), the lytic switch protein. Here, we further investigated the possible cellular microRNAs (miRNAs) involved in regulation of RTA during HSV-1-induced KSHV replication. The differential profiles of miRNAs expression between Mock- and HSV-1-infected body cavity-based lymphoma (...
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Yan Q, Li W, Tang Q, Yao S, Lv Z, Feng N, Ma X, Bai Z, Zeng Y, Qin D, Lu C Tags: PLoS One Source Type: research

Human Cytomegalovirus Infection Enhances NF-κB/p65 Signaling in Inflammatory Breast Cancer Patients.
Abstract Human Cytomegalovirus (HCMV) is an endemic herpes virus that re-emerges in cancer patients enhancing oncogenic potential. Recent studies have shown that HCMV infection is associated with certain types of cancer morbidity such as glioblastoma. Although HCMV has been detected in breast cancer tissues, its role, if any, in the etiology of specific forms of breast cancer has not been investigated. In the present study we investigated the presence of HCMV infection in inflammatory breast cancer (IBC), a rapidly progressing form of breast cancer characterized by specific molecular signature. We screened for anti...
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: El-Shinawi M, Mohamed HT, El-Ghonaimy EA, Tantawy M, Younis A, Schneider RJ, Mohamed MM Tags: PLoS One Source Type: research

A case of relapsing kikuchi-fujimoto disease.
Abstract Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis was first described in Japan in 1972. It is described as a benign syndrome most commonly involving cervical lymphadenopathy, fever, and night sweats. The etiology of KFD is unknown but it is thought to be triggered by an autoimmune or viral process with an exaggerated T-cell-mediated immune response. KFD can mimic other serious conditions such as lymphoma, systemic lupus erythematosus (SLE), herpes simplex, and Epstein Barr virus. Diagnosis is confirmed histopathologically. Kikuchi's disease is typically reported to have a self-limitin...
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Rezayat T, Carroll MB, Ramsey BC, Smith A Tags: Case Report Otolaryngol Source Type: research

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature.
We describe two HIV-negative patients who presented with primary effusion lymphoma of B-cell lineage involving the pleural cavity, but whose tumor cells lacked infection by HHV8. We review the English language literature of HHV8-negative PEL of B-cell lineage and compare these lymphomas to HHV8-associated PEL with regard to clinical and pathological characteristics, therapy, and outcome. PMID: 23401819 [PubMed] (Source: Herpes)
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Saini N, Hochberg EP, Linden EA, Jha S, Grohs HK, Sohani AR Tags: Case Rep Oncol Med Source Type: research

Diagnosis and Management of Primary Effusion Lymphoma in the Immunocompetent and Immunocompromised Hosts.
Abstract Primary effusion lymphoma (PEL) is an uncommon non-Hodgkin lymphoma associated with human herpes virus-8 (HHV-8) that grows mainly in serous body cavities. The most common presentation of PEL is that of a young immunocompromised male with shortness of breath, as the pleural cavity is most commonly affected. Diagnosis is primarily based on fluid cytology in which PEL cells display variable morphology and a null lymphocyte immunophenotype; however, evidence of HHV-8 infection within the neoplastic cell is essential. Patients have commonly been treated with systemic multidrug chemotherapy and antiretroviral t...
Source: The Thoracic and Cardiovascular Surgeon - February 19, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Ammari ZA, Mollberg NM, Abdelhady K, Mansueto MD, Massad MG Tags: Thorac Cardiovasc Surg Source Type: research

Chorea and Developmental Regression Associated With Human Herpes Virus-6 Encephalitis
We report a 14-month old child with multiple episodes of febrile status epilepticus, followed by chorea and developmental regression, caused by human herpes virus–6 encephalitis. Chorea has been described as a complication of relapsing herpes simplex virus I infection, but not as a manifestation of human herpes virus–6 infection. It is uncertain whether the chorea was an autoimmune phenomenon or a direct effect of the virus. The child was treated with levetiracetam, intravenous immunoglobulin, and foscarnet. The seizures and chorea resolved with treatment, but developmental regression, with loss of language skills, per...
Source: Pediatric Neurology - February 18, 2013 Category: Neurology Authors: Anoop S. Pulickal, Simi Ramachandran, Philippe Rizek, Pramod Narula, Romaine Schubert Tags: Case Reports Source Type: research

Severe cutaneous necrosis due to mixed infection with herpes simplex virus and fungi in an unrelated cord blood stem cell transplantation recipient
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - February 18, 2013 Category: Dermatology Authors: Kanami Saito, Yutaka Hatano, Tomoko Okamoto, So‐ichi Suenobu, Tatsuro Izumi, Kaho Matsuda, Fumiaki Shimizu, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

The pictorial atlas of common genito-urinary medicine
The words ‘Pictorial Atlas’ in this book's title had me eagerly anticipating its arrival and it does indeed feature pictures on almost every page. The author built up a collection of photographs during his 30 years of working in genitourinary medicine (GUM) in the UK and Saudi Arabia and describes the book as a ‘pictorial supplement’ to standard works on GUM. The first chapter summarises the anatomy and function of the genitalia and reproductive organs. Although generally concise and clear, a little more 'applied' anatomy might have been helpful such as the landmarks for a bimanual examination....
Source: Sexually Transmitted Infections - February 18, 2013 Category: Sexual Medicine Authors: Redfern, B. Tags: Miscellaneous Source Type: research

Prevalence of HIV and other sexually transmitted infections and factors associated with syphilis among female sex workers in Panama
Conclusions Although HIV prevalence is low among FSWs in Panama, unregistered FSWs bear a higher burden of HIV and STIs than registered FSWs. Programmes aimed at overcoming obstacles to registration, and HIV, STI and harm reduction among unregistered FSWs is warranted to prevent HIV transmission, and to improve their sexual and reproductive health. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - February 18, 2013 Category: Sexual Medicine Authors: Hakre, S., Arteaga, G., Nunez, A. E., Bautista, C. T., Bolen, A., Villarroel, M., Peel, S. A., Paz-Bailey, G., Scott, P. T., Pascale, J. M., the Panama HIV EPI Group Tags: Liver disease, Health policy, Epidemiologic studies, Open access, Drugs: infectious diseases, Hepatitis and other GI infections, HIV/AIDS, Hepatitis (sexual health), HIV / AIDS, Syphilis, HIV infections, Sex workers Epidemiology Source Type: research

Severe cutaneous necrosis due to mixed infection with herpes simplex virus and fungi in an unrelated cord blood stem cell transplantation recipient.
PMID: 23414251 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 18, 2013 Category: Infectious Diseases Authors: Saito K, Hatano Y, Okamoto T, Suenobu SI, Izumi T, Matsuda K, Shimizu F, Fujiwara S Tags: J Dermatol Source Type: research

Report of Three Cases of Herpes Zoster During Treatment with Natalizumab.
PMID: 23419219 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - February 18, 2013 Category: Neuroscience Authors: Fragoso YD, Brooks JB, Gomes S, de Oliveira FT, Gama PD Tags: CNS Neurosci Ther Source Type: research

Vaccination of older adults against herpes zoster is safe and effective.
PMID: 23416421 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - February 16, 2013 Category: Infectious Diseases Authors: Tyring SK Tags: Evid Based Med Source Type: research

UCLA study suggests link between untreated depression, response to shingles vaccine
Can an individual's state of mind effect how well a vaccine may work? In the case of seniors and shingles, the answer is yes. Reporting in the current online edition of the journal Clinical Infectious Diseases, Dr. Michael Irwin, a professor of psychiatry at the Semel Institute for Neuroscience and Human Behavior at UCLA, demonstrates a link between untreated depression in older adults and decreased effectiveness of the herpes zoster —or shingles — vaccine. Shingles is a painful, blistering skin rash that can last for months or even years. It's caused by the varicella–zoster virus, the ...
Source: UCLA Newsroom: Health Sciences - February 15, 2013 Category: Universities & Medical Training Source Type: news

Natural Herpes Cure Resolve Herpes Launches Improved Version that is...
The new formula is available in a two-step, 50-day detox program(PRWeb February 14, 2013)Read the full story at http://www.prweb.com/releases/2013/2/prweb10427687.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 15, 2013 Category: Pharmaceuticals Source Type: news

STDs Are An Epidemic In The U.S., CDC Warns
In step with Valentine's Day, the Centers for Disease Control and Prevention (CDC) announced that the U.S. has around 110 million cases of sexually transmitted diseases (STDs or STIs), amounting to 20 million new infections each year, and it is only getting worse. The announcement followed two new studies just released by the CDC. They revealed the following STDs as the most common: human papilloma virus (HPV) chlamydia gonorrhea syphilis herpes hepatitis b trichomoniasis HIV Over half of these infections are in the young adult population, those aged 15 to 24 years... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 15, 2013 Category: Consumer Health News Tags: Sexual Health / STDs Source Type: news

Aciclovir: Development of resistance in herpes simplex virus type 1 infection in a neonate: case report
(Source: Reactions)
Source: Reactions - February 15, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Intrahost genetic variability of human herpes virus‐8
Abstract Studies were conducted to determine whether HHV‐8 hyperactivity could be the consequence of the propensity of the host to multiple HHV‐8 infection. The aim of the present work was to investigate HHV‐8 intrahost genetic variability. HHV‐8 subgenomic DNA was amplified by PCR from patients infected with HIV, health care workers (HCW) and bone marrow transplant recipients (BMT), and from oral lesional tissues of AIDS‐Kaposi's sarcoma (KS) patients. As controls, blood from HIV‐negative health care workers, and the cell lines BC‐1, BC‐2, and BCP‐1 were used. Clones derived from amplicons originating fr...
Source: Journal of Medical Virology - February 15, 2013 Category: Virology Authors: Jair Carneiro Leao, Andreza Barkokebas Santos de Faria, Déborah Daniela Diniz Fonseca, Luiz Alcino Monteiro Gueiros, Igor Henrique Morais Silva, Stephen R. Porter Tags: Research Article Source Type: research

Effects of Herpes Simplex Virus Vector–Mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception
Human Gene Therapy , Vol. 0, No. 0. (Source: Human Gene Therapy)
Source: Human Gene Therapy - February 14, 2013 Category: Genetics & Stem Cells Tags: article Source Type: research

Treating Depression May Boost Vaccine ResponseTreating Depression May Boost Vaccine Response
Treating major depression in older adults may significantly boost their response to vaccines, such as for herpes zoster. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 14, 2013 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Depression May Lower Response to Shingles Vax (CME/CE)
(MedPage Today) -- Untreated major depression may hamper the protective effect of varicella zoster virus vaccine against herpes zoster -- shingles -- in older individuals, researchers found. (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - February 14, 2013 Category: Consumer Health News Source Type: news

Study Suggests Link Between Untreated Depression And Response To Shingles Vaccine
Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine. Older adults are known to be at risk for shingles, a painful condition caused by the reactivation of the varicella-zoster virus, and more than a million new cases occur each year in the U.S. The vaccine boosts cell-mediated immunity to the virus and can decrease the incidence and severity of the condition... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 14, 2013 Category: Consumer Health News Tags: Depression Source Type: news

Study suggests link between untreated depression and response to shingles vaccine
(Infectious Diseases Society of America) Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine. Older adults are known to be at risk for shingles, a painful condition caused by the reactivation of the varicella-zoster virus, and more than a million new cases occur each year in the US. The vaccine boosts cell-mediated immunity to the virus and can decrease the incidence and severity of the condition. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 14, 2013 Category: Global & Universal Source Type: news

Long-Term Safety of Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: Results from Phase 3 FREEDOMS II Extension Study (P01.165)
CONCLUSIONS: The long-term safety results of FREEDOMS II extension study were generally consistent with previous fingolimod studies. Switching therapy from placebo to fingolimod after 24 months identified no unexpected safety concerns.Supported by: Novartis Pharma AG, Basel, Switzerland.Disclosure: Dr. Vollmer has received personal compensation for activities with Genzyme Corporation, Acorda Therapeutics, Accelerated Cure Projects for MS, Bristol-Myers Squibb Company, Teva Neuroscience, Biogen Idec, Novartis, and Hoffman-LaRoche. Dr. Vollmer has received research support from Teva Neuroscience, Genzyme Corporation, Ono Pha...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Vollmer, T., Jeffery, D., Goodin, D., Kappos, L., Lublin, F., Radue, E.-W., Rammohan, K., Reder, A., Agius, M., Stites, T., Li, B., Cappiello, L., von Rosenstiel, P., Calabresi, P. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Frequency of Infections during Treatment with Teriflunomide: Pooled Data from Three Placebo-Controlled Teriflunomide Studies (P01.171)
CONCLUSIONS: Teriflunomide had a low incidence of serious infections, which was not different from placebo. Mean reductions in WBC counts were small in magnitude, often stabilized during treatment, and were not associated with infections. These findings provide evidence that risk of infection is not increased by teriflunomide treatment.Supported by: Genzyme, a Sanofi company.Disclosure: Dr. Singer has received personal compensation for activities with Acorda, Bayer, Biogen Idec, EMD Serono, Genentech, Genzyme, Novartis, Pfizer and Teva as a speaker or consultant. Dr. Singer has received research support from Biogen-Idec, G...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Singer, B., Comi, G., Miller, A., Olsson, T., Wolinsky, J., Kappos, L., Confavreux, C., Freedman, M., Benzerdjeb, H., Li, H., Truffinet, P., O'Connor, P. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Comparison of Infection Risk with Alemtuzumab and SC IFNB-1a in Patients with Multiple Sclerosis Who Experienced Disease Activity While on Prior Therapy (CARE-MS II) (P01.172)
CONCLUSIONS: Although alemtuzumab increased the risk for infection compared with IFNB-1a in CARE-MS II, all infections were manageable, few were serious, and none led to study discontinuation.Supported by: Genzyme, a Sanofi company and Bayer Healthcare Pharmaceuticals.Disclosure: Dr. Wray has received personal compensation for activities with Serono, Inc., Bayer Pharmaceuticals Corporation, Genzyme Corporation, Biogen Idec, Novartis and Teva Neuroscience as a consultant, speaker and/or serving on an advisory board. Dr. Wray has received research support from Accorda, Biogen Idec, Elan, Genzyme, Novartis, Ono, Roche and Ser...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Wray, S., Arnold, D., Cohen, J., Coles, A., Confavreux, C., Fox, E., Hartung, H., Havrdova, E., Selmaj, K., Weiner, H., Miller, T., Twyman, C., Lake, S., Margolin, D., Panzara, M., Compston, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Oral Cladribine Safety Profile in Patients with a First Demyelinating Event: Top Line Results from the Phase III ORACLE MS Study (P01.177)
CONCLUSIONS: The safety profile of oral cladribine in early MS is similar to that of the CLARITY study, except for less cladribine-associated lymphocyte toxicity. Two malignancies occurred, both in cladribine-treated patients, and were unlikely related to the study treatment given the short latencies and presence of other risk factors.Supported by: Merck Serono S.A. – Geneva, Switzerland, an affiliate of Merck KGaA, Darmstadt, Germany.Disclosure: Dr. Leist has received personal compensation for activities with EMD Serono, Teva Neuroscience, Biogen, Bayer, and Pfizer as a consultant. Dr. Leist has received research su...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Leist, T., Comi, G., Cree, B., Coyle, P., Freedman, M., Hartung, H., Vermersch, P., Orejudos, A., Lachenal, N., Scaramozza, M. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

An Open-Label Observational Pilot Study To Evaluate the Safety and Immunogenicity of the Herpes Zoster Vaccine in Patients with Multiple Sclerosis (P01.181)
CONCLUSIONS: We believe this is the largest systematic observational study of the HZV in MS. There were no exacerbations, no new enhancing or T2 lesions, and no changes in T1 /T2 volumes. VZV IgG antibody levels increased indicating expected immunogenicity. Although this study was not designed to definitively establish safety, it provides evidence to suggest that the HZV may be safely administered in MS patients.Supported by: Grant from the Consortium of Multiple Sclerosis Centers.Disclosure: Dr. McGraw has received personal compensation for activities with Biogen Idec. Dr. Inglese has received personal compensation for ac...
Source: Neurology - February 14, 2013 Category: Neurology Authors: McGraw, C., Inglese, M., Petracca, M., Hannigan, C., Miller, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Inflammatory Variant of Cerebral Amyloid Angiopthy Mimicking Herpes Encephalitis (P02.043)
CONCLUSIONS: The typical MRI appearance and the good response to steroids point to the by the inflammatory variant of cerebral amyloid angiopathy as correct diagnosis, which is a clinical, neuroradiological, histological and genetical disease entitiy of its own (Kinnecom et al., Neurology 2007). In such cases, its diagnosis does not necessarily require a brain biopsy.Disclosure: Dr. Heide has received personal compensation for activities with Bayer and Sanofi-Aventis Pharmaceuticals, Inc. Dr. Pape has nothing to disclose. (Source: Neurology)
Source: Neurology - February 14, 2013 Category: Neurology Authors: Heide, W., Pape, O. Tags: P02 Cerebrovascular Disease II Source Type: research

Hemiparesis and Demyelination as Presentation of NMDA Receptor Antibody Encephalitis (P02.111)
CONCLUSIONS: NMDA antibody receptor encephalitis is usually a paraneoplastic syndrome associated with ovarian teratoma or dermoid cyst. To our knowledge, a presentation with hemiparesis; and gray and white matter involvement with mass effect mimicking a tumor has not previously been reported. The biopsy results were confusing by showing demyelination and diagnosis of atypical MS was initially considered. In conclusion, NMDA receptor encephalitis should be considered in cases with bitemporal mass lesions presented with hemiparesis. A biopsy showing demyelination does not rule out the diagnosis.Disclosure: Dr. Bollu has noth...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Bollu, P., Vellipuram, A., Sandhu, D., Miller, D., Chuquilin Arista, M. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Viral and Genetic Risk Factors for Pediatric Neuromyelitis Optica (P02.114)
CONCLUSIONS: NMO patients have lower prevalence of HLA-DRB1*15:01 and HSV-1 exposure compared to those with MS but these prevalences are similar to controls. Larger case-control studies are needed to confirm these findings.Supported by: The Guthy Jackson Charitable Foundation.Disclosure: Dr. Grandhe has nothing to disclose. Dr. Graves has nothing to disclose. Dr. Mowry has received research support from Teva Neuroscience. Dr. Krupp has received personal compensation for activities with Teva Neuroscience, Biogen Idec, EMD Serono, MEDA Corp, Acorda Therapeutics, Betaseron/Bayer Healthcare, Gerson Lehrman Group, Guidepoint Gl...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Grandhe, S., Graves, J., Mowry, E., Krupp, L., Chitnis, T., Ness, J., Belman, A., Milazzo, M., Gorman, M., Weinstock-Guttman, B., Rodriguez, M., Patterson, M., James, J., Waubant, E. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Risk Factors for Transverse Myelitis Compared with Multiple Sclerosis, Neuromyelitis Optica, and Other Neurologic Disorders in Pediatric Patients (P02.121)
CONCLUSIONS: Unlike pediatric and adult MS, EBV exposure does not appear to be associated with TM in pediatric patients. Larger studies are needed to confirm this association.Supported by: TM and some NMO sera were provided by the Accelerated Cure/Guthy Jackson Foundation. The Pediatric MS Centers are supported by the NMSS. KW is supported by a grant from the Dean's Office Medical Student Research Program at UCSF. Dr. Graves is supported by the NMSS (Sylvia Lawry award) and the CMSC.Disclosure: Dr. Weinfurtner has nothing to disclose. Dr. Graves has nothing to disclose. Dr. Mowry has received research support from Teva Neu...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Weinfurtner, K., Graves, J., Mowry, E., Krupp, L., Belman, A., Milazzo, M., James, J., Waubant, E. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Acute Aseptic Encephalitis and Reversible Auditory Verbal Agnosia Following Rapid Immune Reconstitution in AIDS: A Case Report (P03.247)
CONCLUSIONS: Although IRIS generally manifests as inflammation against subclinical or persistent infection in HIV patients, this case of IRIS occurred against HIV itself (HIVE-IRIS). Strategic cerebral lesions due to HIVE-IRIS were substrates in this reversible auditory verbal agnosia. In patients with acute HIVE-IRIS with significant neurological deficit without OI, corticosteroid therapy is effective for salvaging neurological function.Disclosure: Dr. Roh has nothing to disclose. Dr. Glenn has nothing to disclose. Dr. Anzalone has nothing to disclose. Dr. Petito has nothing to disclose. Dr. Post has nothing to disclose. ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Roh, D., Glenn, M., Anzalone, S., Petito, C., Post, J., Verma, A. Tags: P03 Infections I Source Type: research