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Newborn hearing screening on infants at riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our selected hearing screening on infants at risk allowed 60 deaf children access to early management. However, too many children were lost to follow up; which revealed that better information regarding risk of hearing loss must be provided to parents and paramedics and universal newborn screening needs to be performed. The most important result of this study is that in a population of hearing impaired children, with an impairment incidence close to what is commonly reported, the association of several risk factors proves to be a significant additional risk factor for hearing impairment. (Source: International ...
Source: International Journal of Pediatric Otorhinolaryngology - November 20, 2009 Category: ENT & OMF Authors: Christine Ohl, Liliane Dornier, Cécile Czajka, Jean-Claude Chobaut, Laurent Tavernier Tags: Research papers Source Type: journals

Immune systems and ageingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This well-conducted scientific study looked at complex immune pathways in mice and appears to have been over-interpreted in the study’s press release and lay media reports, which suggest that these findings have important implications for seasonal flu and H1N1 vaccination. It is important that scientists study the complex mechanisms in animal and human immunity, and this early research warrants further exploration. However, given the experimental nature of this animal study, it is premature to conclude that this study is relevant to flu vaccination programmes. Links To The Headlines Elderly people succumb to ...
Source: NHS News Feed - November 19, 2009 Category: Consumer Health News Tags: Older people Source Type: news

Herpes Never SleepsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Virus may not lay dormant in the body, as previously suspected [Read more] (Source: ScienceNOW)
Source: ScienceNOW - November 19, 2009 Category: Science Authors: Martin Enserink Source Type: news

Epiphany Announces Positive Results from Its Phase 2b Trial in Shingles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SAN FRANCISCO, Nov. 18 /PRNewswire/ -- Epiphany Biosciences announced results from its Phase 2b dose-ranging study of EPB-348 (valomaciclovir) in patients with shingles (herpes zoster) infection. The study's primary endpoint was non-inferiority... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 19, 2009 Category: Pharmaceuticals Source Type: clinical trials

Giant Microbes: Soft toy versions of bacteria and viruses such as HIV Herpes Swine Flu and EbolaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Soft toy versions of bacteria and viruses like Swine Flu and Ebola. (Source: The Telegraph : Swine Flu A H1N1)
Source: The Telegraph : Swine Flu A H1N1 - November 19, 2009 Category: Infectious Diseases Source Type: news

Epiphany Announces Positive Results From Its Phase 2b Trial In ShinglesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epiphany Biosciences announced results from its Phase 2b dose-ranging study of EPB-348 (valomaciclovir) in patients with shingles (herpes zoster) infection. The study's primary endpoint was non-inferiority of once-daily valomaciclovir compared to thrice-daily valacyclovir in terms of time to complete crusting of the shingles rash. (Source: Seniors / Aging News From Medical News Today)
Source: Seniors / Aging News From Medical News Today - November 19, 2009 Category: Geriatrics Tags: Seniors / Aging Source Type: news

Epiphany Announces Positive Results From Its Phase 2b Trial In ShinglesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epiphany Biosciences announced results from its Phase 2b dose-ranging study of EPB-348 (valomaciclovir) in patients with shingles (herpes zoster) infection. The study's primary endpoint was non-inferiority of once-daily valomaciclovir compared to thrice-daily valacyclovir in terms of time to complete crusting of the shingles rash. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 19, 2009 Category: Consumer Health News Tags: Seniors / Aging Source Type: news

Genital Herpes May Never Go DormantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Genital Herpes May Never Go DormantCategory: Health NewsCreated: 11/18/2009 4:10:00 PMLast Editorial Review: 11/19/2009 (Source: MedicineNet Womens Health General)
Source: MedicineNet Womens Health General - November 19, 2009 Category: OBGYN Source Type: consumer

Circumcision and Risk of Sexually Transmissible Infections in a Community-Based Cohort of HIV-Negative Homosexual Men in Sydney, Australia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. PMID: 19911990 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - November 19, 2009 Category: Infectious Diseases Authors: Templeton DJ, Jin F, Prestage GP, Donovan B, Imrie JC, Kippax SC, Cunningham PH, Kaldor JM, Mindel A, Cunningham AL, Grulich AE Tags: J Infect Dis Source Type: journals

Prevalence of Trichomonas vaginalis infection among young reproductive age women in India: implications for treatment and prevention.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The burden of T. vaginalis infection at 8.5% is relatively high among a community sample of young reproductive aged women. Because this infection increases the risk of HIV transmission and is associated with adverse pregnancy outcomes, there is a need for increased screening and treatment of this easily curable sexually transmissible infection in India. PMID: 19917204 [PubMed - in process] (Source: Herpes)
Source: Herpes - November 19, 2009 Category: Infectious Diseases Authors: Madhivanan P, Bartman MT, Pasutti L, Krupp K, Arun A, Reingold AL, Klausner JD Tags: Sex Health Source Type: journals

Herpes Virus Shedding Studied With Mathematical ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
People infected with herpes simplex virus 2 experience almost constant releases of small numbers of viruses from the neurons that host them into the genital tract, which may make prevention of person-to-person transmission difficult, according to a mathematical model of HSV-2 behavior described in a paper published online Nov. 18 in Science Translational Medicine. (Source: Modern Medicine)
Source: Modern Medicine - November 19, 2009 Category: Journals (General) Source Type: info

Genital Herpes May Never Go DormantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Study finds low level shedding may be continuous, infection state unclear Source: HealthDay Related MedlinePlus Topic: Herpes Simplex (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - November 18, 2009 Category: Consumer Health News Source Type: consumer

AIDS, UTI, Herpes Vaccines May Exist In 5 YearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. Many could be on the market in five years or less. Contrast that with five years ago, when so many companies had abandoned the vaccine business that half the U.S. supply of flu shots was lost because of factory contamination at one of the two manufacturers left. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 18, 2009 Category: Consumer Health News Source Type: consumer

Vaccines on horizon for Alzheimer's, herpes, AIDSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: CTV Health)
Source: CTV Health - November 18, 2009 Category: Consumer Health News Source Type: news

How aging compromises antiviral defenses: a role for imbalanced innate cytokine production.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aging causes enhanced susceptibility to viral infections. Stout-Delgado et al. (2009) report increased IL-17A production but reduced type I interferon levels in old mice infected by herpes viruses. This imbalance between proinflammatory and antiviral innate cytokine responses causes immunopathology and compromises virus control, which together lead to death by liver failure. PMID: 19917493 [PubMed - in process] (Source: Cell Host and Microbe)
Source: Cell Host and Microbe - November 18, 2009 Category: Microbiology Authors: Guiton R, Dalod M Tags: Cell Host Microbe Source Type: journals

Aging Promotes Neutrophil-Induced Mortality by Augmenting IL-17 Production during Viral Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Morbidity and mortality associated with viral infections increase with age, although the underlying mechanisms are unclear. Here, we investigated whether aging alters inflammatory responses during systemic viral infection and thereby contributes to virus-induced death. We found that infection of aged mice with systemic herpes viruses led to rapid increases in serum IL-17, neutrophil activation, and mortality due to hepatocyte necrosis. In contrast, all young mice survived infection, displaying weaker IL-17 induction and neutrophil activation. Natural killer T (NKT) cells isolated from the livers of aged mice produced m...
Source: Cell Host and Microbe - November 18, 2009 Category: Microbiology Authors: Stout-Delgado HW, Du W, Shirali AC, Booth CJ, Goldstein DR Tags: Cell Host Microbe Source Type: journals

Vaccines on Horizon for AIDS, Alzheimer's, HerpesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
From Associated Press (November 18, 2009) MARIETTA, Pa._Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 18, 2009 Category: Pharmaceuticals Source Type: news

Vaccines On Horizon For AIDS, HerpesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 18, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news

Vaccines for AIDS, Alzheimer's, herpes on the horizonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. Many could be on the market in... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 18, 2009 Category: American Health Source Type: news

Vaccines On Horizon For AIDS, Alzheimer's, HerpesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it. (Source: WDSU.com - Health)
Source: WDSU.com - Health - November 17, 2009 Category: Consumer Health News Authors: WDSU.com Source Type: news

'Golden era' could bring vaccines against AIDS, Alzheimer's and addictions within 5 yearsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MARIETTA, Pa. (AP) — Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it.... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - November 17, 2009 Category: American Health Source Type: news

Skin metastasis: a pathologist's perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents a literature review concerning these issues as well as this author's experience encountered throughout 19 years of surgical pathology and dermatopathology practice. Several conclusions are evident. Generally, skin metastases are encountered in 0.7[ndash]9% of all patients with cancer and as such the skin is an uncommon site of metastatic disease when compared to other organs. There is usually a long-time lag between the diagnosis of the primary malignancy and the recognition of the skin metastases. However, these metastases may be the first indication of the clinically silent visceral malignancies. The ...
Source: Journal of Cutaneous Pathology - November 17, 2009 Category: Pathology Authors: Mahmoud Rezk Abdelwahed Hussein Source Type: journals

Amelioration of myocarditis by HVEM-overexpressing dendritic cells through induction of IL-10-producing cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Myosin-DC-AdHVEM cell gene therapy appears to be a safe and effective way of inhibiting the development of EAM. The signal induced by HVEM seems to play different roles in different cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Cai, G., Wang, H., Qin, Q., Zhang, J., Zhu, Z., Liu, M., Shen, Q. Tags: ORIGINAL ARTICLES Source Type: journals

Cost Effectiveness of Herpes Zoster Vaccine in CanadaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PharmacoEconomics)
Source: PharmacoEconomics - November 16, 2009 Category: Health Management Authors: Najafzadeh, MehdiMarra, Carlo A.Galanis, EleniPatrick, David M. Tags: Original Research Articles Source Type: journals

Willingness to Pay for a QALY Based on Community Member and Patient Preferences for Temporary Health States Associated with Herpes ZosterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: PharmacoEconomics)
Source: PharmacoEconomics - November 16, 2009 Category: Health Management Authors: Lieu, Tracy A.Ray, G. ThomasOrtega-Sanchez, Ismael R.Kleinman, KenRusinak, DonnaProsser, Lisa A. Tags: Original Research Articles Source Type: journals

Azathioprine: Herpes simplex virus type 1 infection: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV MelanomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Melanoma patients present with elevated levels of Tregs, Ts, and MDSC within established tumors. Direct injection of OncovexGM-CSF induces local and systemic antigen-specific T cell responses and decreases Treg, Ts, and MDSC in patients exhibiting therapeutic responses. Content Type Journal ArticleCategory MelanomasDOI 10.1245/s10434-009-0809-6Authors Howard L. Kaufman, Rush University Medical Center Department of Surgery, Medicine and Immunology Chicago IL USADae Won Kim, Rush University Medical Center Department of Surgery, Medicine and Immunology Chicago IL USAGail DeRaffele, Mount Sinai...
Source: Annals of Surgical Oncology - November 14, 2009 Category: Cancer & Oncology Tags: Annals of Surgical Oncology Source Type: journals

Herpes Simplex Virus Epithelial Keratitis (Tabery)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In Vivo Morphology in the Human Cornea Herpes Simplex Virus Epithelial Keratitis provides a kind of ‘living histology’, revealing both morphological and dynamic features of the disease, and explaining the mechanisms behind them. It discusses in detail: ° the result of herpes simplex virus impact on the living human epithelium ° the step-by-step dynamics of healing during a successful treatment ° the ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - November 14, 2009 Category: Databases & Libraries Tags: Ophthalmology Source Type: organizations

Circumcision and Risk of Sexually Transmissible Infections in a Community‐Based Cohort of HIV‐Negative Homosexual Men in Sydney, AustraliaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. These are the first prospective data obtained from homosexual men to assess circumcision status as a risk factor for STIs. Circumcised men were at reduced risk of incident syphilis but no other prevalent or incident STIs. Circumcision is unlikely to have a substantial public health impact in reducing acquisition of most STIs in homosexual men. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - November 13, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

The Endoplasmic Reticulum of Dorsal Root Ganglion Neurons Contains Functional TRPV1 Channels [Mechanisms Of Signal Transduction]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Transient receptor potential vanilloid type 1 (TRPV1) is a plasma membrane Ca2+ channel involved in transduction of painful stimuli. Dorsal root ganglion (DRG) neurons express ectopic but functional TRPV1 channels in the endoplasmic reticulum (ER) (TRPV1ER). We have studied the properties of TRPV1ER in DRG neurons and HEK293T cells expressing TRPV1. Activation of TRPV1ER with capsaicin or other vanilloids produced an increase of cytosolic Ca2+ due to Ca2+ release from the ER. The decrease of [Ca2+]ER was directly revealed by an ER-targeted aequorin Ca2+ probe, expressed in DRG neurons using a herpes amplicon virus. The sen...
Source: Journal of Biological Chemistry - November 13, 2009 Category: Chemistry Authors: Gallego-Sandin, S., Rodriguez-Garcia, A., Alonso, M. T., Garcia-Sancho, J. Tags: Mechanisms Of Signal Transduction Source Type: journals

Health News of the DayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:5 Pathogens Linked to Risk for Stroke: Chlamydia pneumoniae, Helicobacter pylori, CMV, herpes simplex viruses 1 and 2 http://bit.ly/3UUisRFDA looks for ways to regulate drug promotion on Twitter, Wikipedia, blogs and other social media http://bit.ly/1fJ1X85% of winter deaths are caused by influenza http://bit.ly/3tU1oRHow to avoid falling victim to a hospital mistake - CNN http://bit.ly/1dUL1TVideo: Top 10 Tips for Residency...
Source: Clinical Cases and Images - November 13, 2009 Category: Journals (General) Tags: Health News of the Day Source Type: info

Expression, Purification of Herpes Simplex Virus Type 1 UL4 Protein, and Production and Characterization of UL4 Polyclonal Antibody.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The herpes simplex virus type 1 (HSV-1) UL4 protein is a late protein encoded by the UL4 gene. To date, the function of this protein is poorly understood. To aid further investigation of the function of this protein, the UL4 gene was cloned into the vector pET-28a (+) to express His-tagged UL4 protein in Escherichia coli. The recombinant fusion protein was purified from inclusion body by histidine selected nickel affinity chromatography under denaturing conditions. After refolding, the purified recombinant protein was used to produce anti-UL4 polyclonal antibody. Western blot analysis demonstrated that the polyclonal s...
Source: Journal of Virological Methods - November 13, 2009 Category: Virology Authors: Pan W, Ren X, Guo H, Ding Q, Zheng AC Tags: J Virol Methods Source Type: journals

1{alpha},25-Dihydroxyvitamin D3 and Its TX527 Analog Inhibit the Growth of Endothelial Cells Transformed by Kaposi Sarcoma-Associated Herpes Virus G Protein-Coupled Receptor in Vitro and in Vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we have demonstrated that 1alpha,25(OH)2D3 and its TX527 analog have antiproliferative effects on the growth of endothelial cells transformed by the vGPCR in vitro and in vivo, the vitamin D receptor being part of the inhibitory mechanism of action. PMID: 19915163 [PubMed - as supplied by publisher] (Source: Endocrinology)
Source: Endocrinology - November 13, 2009 Category: Endocrinology Authors: Gonzalez-Pardo V, Martin D, Gutkind JS, Verstuyf A, Bouillon R, Russo de Boland A, Boland RL Tags: Endocrinology Source Type: journals

Infectious Encephalitis in France in 2007: A National Prospective StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our prospective study provides an overview of the clinical and etiologic patterns of acute infectious encephalitis in adults in France. Herpes simplex virus 1 remains the main cause of encephalitis, but bacteria accounts for the highest case‐fatality rates. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - November 12, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Vital Signs: Risks: 5 Pathogens Linked to Risk for StrokeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The lead author of a study said low-level infection and inflammation in vessel walls might be leading to disease. (Source: NYT > Health)
Source: NYT > Health - November 12, 2009 Category: Consumer Health News Authors: By RONI CARYN RABIN Tags: Stroke Bacteria Helicobacter Pylori (Bacterium) herpes Viruses Medicine and Health Source Type: news

Regulation of Angiogenesis in Malignancies Associated With Epstein-Barr Virus and Kaposi's Sarcoma-Associated Herpes VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New treatment modalities that target members of the VEGF family have gained approval for clinical use in cancer. Future Microbiology (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 12, 2009 Category: Drugs & Pharmacology Tags: Pathology & Lab Medicine Source Type: info

Newer trends in the management of genital herpesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nath Amiya Kumar, Thappa Devinder MohanIndian Journal of Dermatology, Venereology, and Leprology 2009 75(6):566-574Management of genital herpes is complex. Apart from using the standard antivirals, an ideal management protocol also needs to address various aspects of the disease, including the psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Long-term suppressive therapy is effective in reducing the number of recurrences and the risk of transmission to others. Severe or disseminated disease may require intravenous therapy. Resistant cases are managed with foscarnet or ci...
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Nath Amiya Kumar, Thappa Devinder Mohan Source Type: journals

Does circumcision influence recurrences in herpes genitalis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions:</b> Six patients and six controls did not follow-up. Seven patients reported no recurrences during 3-18 years, seven patients had two to six recurrences during 11-27 years of postcircumcision follow-up, 0.0080 (average) recurrences per person per year as compared with 0.20 (average) recurrences per person per year recorded before the circumcision. Two patients had first recurrence 11 years after the circumcision. In comparison, 14 controls had 0.17 (average) recurrences per person per year, comparable with the number of recurrences in uncircumcised patients, and frequently at shorter interv...
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Jerath V P, Mahajan Vikram K Source Type: journals

[An herpes virus colonic infection in the initial presentation of an ulcerative colitis : diagnostic difficulties.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19914028 [PubMed - as supplied by publisher] (Source: Presse Medicale)
Source: Presse Medicale - November 12, 2009 Category: Journals (General) Authors: Kallel L, Nijaa N, Haouet S, Bahri O, Boubaker J, Filali A Tags: Presse Med Source Type: journals

Infections Such as Pneumonia and Herpes May Heighten Stroke RiskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers report that infections increase the risk for stroke through their aggregate effect on vascular inflammation. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 11, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Common Infections Linked to Increased Stroke Risk (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
People who contract common infections such as herpes and ulcer-causing viruses appear to be at increased risk of stroke, a new study found. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - November 11, 2009 Category: Cardiology Source Type: news

Herpes Zoster Meningoencephalitis: Not Only a Disease of the Immunocompromised?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory CorrespondenceDOI 10.1007/s15010-009-9092-5Authors A. Douglas, University of Melbourne School of Medicine Parkville VIC 3010 AustraliaP. Harris, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 AustraliaF. Francis, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 AustraliaR. Norton, Townsville Hospital Pathology Queensland 100 Angus Smith Drive Douglas QLD 4814 Australia Journal InfectionOnline ISSN 1439-0973Print ISSN 0300-8126 (Source: Infection)
Source: Infection - November 11, 2009 Category: Infectious Diseases Tags: Infection Source Type: journals

During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins [Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ICP0 is a multifunctional herpes simplex virus protein known primarily as a promiscuous transactivator. In the course of productive infection,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 10, 2009 Category: Science Authors: Gu, H., Poon, A. P., Roizman, B. Tags: Microbiology Source Type: journals

Cloning human herpes virus 6A genome into bacterial artificial chromosomes and study of DNA replication intermediates [Microbiology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cloning of large viral genomes into bacterial artificial chromosomes (BACs) facilitates analyses of viral functions and molecular mutagenesis. Previous derivations... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 10, 2009 Category: Science Authors: Borenstein, R., Frenkel, N. Tags: Microbiology Source Type: journals

Use of therapeutic drug monitoring in the long-term valaciclovir therapy of relapsing herpes simplex virus encephalitis in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Lim, M., Menson, E., Tong, C. Y. W., Lin, J.-P. Tags: Research letters Source Type: journals

FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The results showed, for the first time, that the bacterial-derived TLR2/6 agonist FSL-1 induced significant resistance to HSV-2 infection when applied in mice or human vaginal EC cultures. Cytokine evaluation illustrated that anti-herpetic activity correlated with induction of a specific profile. The identified anti-herpetic profile provides an invaluable resource for the future design of novel compounds to reduce genital HSV-2 transmission and improves understanding of the complex innate immune response to potential pathogens elicited by the vaginal mucosa. (Source: BioMed Central)
Source: BioMed Central - November 10, 2009 Category: Journals (General) Authors: William RoseChris McGowinRichard Pyles Source Type: journals

Herpes virus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We suggest that an inherited genetic profile involving TP53 may favor HHV-7 infection and maintenance which, in turn, may initiate and perpetuate GD autoimmune process. PMID: 19903800 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - November 10, 2009 Category: Endocrinology Authors: Leite J, Bufalo N, Santos R, Romaldini J, Ward L Tags: Eur J Endocrinol Source Type: journals

Infectious Burden and Risk of Stroke: The Northern Manhattan Study [Original Contribution]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A quantitative weighted index of infectious burden was associated with risk of first stroke in this cohort. Future studies are needed to confirm these findings and to further define optimal measures of infectious burden as a stroke risk factor.Published online November 9, 2009 (doi:10.1001/archneurol.2009.271). (Source: Archives of Neurology)
Source: Archives of Neurology - November 9, 2009 Category: Neurology Authors: Elkind, M. S. V., Ramakrishnan, P., Moon, Y. P., Boden-Albala, B., Liu, K. M., Spitalnik, S. L., Rundek, T., Sacco, R. L., Paik, M. C. Tags: Bacterial Infections, Viral Infections, Neurology, Cerebrovascular Disease, Stroke, Infectious Diseases Original Contribution Source Type: journals

A novel herpesvirus in the sanctuary chimpanzees on Ngamba Island in UgandaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Non-human primates harbor several herpesviruses many of which are still unknown. This has implications to management of primates in sanctuaries requiring continuous updates on the management protocols to deal with potential occupational pathogens. (Source: Journal of Medical Primatology)
Source: Journal of Medical Primatology - November 9, 2009 Category: Research Authors: L. Mugisha, F.H. Leendertz, J. Opuda-Asibo, J.O. Olobo, B. Ehlers Source Type: journals

Hyperimmunoglobulin E syndrome with a novel STAT3 mutation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 35-year-old man with severe eczematous dermatitis and recurrent staphylococcal skin infections, some of which required hospitalization, is presented. Other medical concerns include recurrent oral staphylococcal infections, otitis media, ocular herpes simplex virus keratitis, asthma, steroid-induced gastritis, steroid-induced cataracts, recurrent upper respiratory infections, and acute pharyngitis. Past medical history includes retained dentition of six primary teeth, two episodes of childhood pneumonia that required hospitalization, and three wrist and ankle fractures. Laboratory data showed an eosinophil count of 2,...
Source: Dermatol Online J - November 7, 2009 Category: Dermatology Authors: Anolik R, Elmariah S, Lehrhoff S, Votava HJ, Martiniuk FT, Levis W Tags: Dermatol Online J Source Type: journals