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Total 221853 results found since Jan 2013.
Correction to: The Relationship Between Forgiveness and Health Outcomes Among People Living with HIV: A Cross-Sectional Study in France
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
Effects of a COVID-19 Public Health Lockdown on Drinking and Health Behavior Among Persons with HIV and with Unhealthy Alcohol use in Uganda
We examined associations between bar-based drinking and decreased alcohol use, and decreased alcohol use and health outcomes (antiretroviral therapy [ART] access, ART adherence, missed clinic visits, psychological stress and intimate partner violence), during lockdown. Of 178 adults sur veyed whose data was analyzed, (67% male, median age: 40), 82% reported bar-based drinking at trial enrollment; 76% reported decreased alcohol use during lockdown. In a multivariate analysis, bar-based drinking was not associated with greater decreases in alcohol use during lockdown compared to non- bar-based drinking (OR = 0.81, 95% CI...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
A Scoping Review of Oral Pre-exposure Prophylaxis for Cisgender and Transgender Adolescent Girls and Young Women: What Works and Where Do We Go from Here?
AbstractAdolescent girls and young women (AGYW) are disproportionately affected by HIV, and oral pre-exposure prophylaxis (PrEP) can reduce HIV acquisition. The purpose of this scoping review was to synthesize results from interventions along the PrEP continuum for AGYW to inform research and programs. We searched electronic databases for studies published between January 2012 –July 2021 and conducted secondary reference searching. Studies were included if they assessed interventions to increase PrEP interest, uptake, or continuation among AGYW. Results were synthesized narratively. Of 2168 citations identified, 50 studi...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
Factors Associated with Antiretroviral Therapy Adherence Among a Community-Based Sample of Sexual Minority Older Adults with HIV
This study utilized a stochastic search variable selection (SVSS) approach to explore potential psychosocial and structural factors associated with HIV-related health outcomes among a community-based sample of older sexual minorities (N = 150) in South Florida, an U.S. HIV-epidemic epicenter. After SVSS, a forward entry regression approach suggested unstable housing, illicit substance use, current nicotine use, and depression were all associated with poorer ART adherence among older sexual minority adults living with HIV. No a ssociations between potential correlates and biological measures of HIV disease severity wer...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
PrEPare for Work: A Pilot Randomized Controlled Trial of an Intervention to Optimize HIV PrEP Outcomes Among Male Sex Workers
AbstractHIV pre-exposure prophylaxis (PrEP) use is limited among male sex workers, who are at exceptionally high-risk for HIV infection. We developed a theory-informed, two-pronged intervention ( “PrEPare-for-Work”) to optimize PrEP initiation and adherence among male sex workers, which was preliminarily evaluated in a two-stage pilot randomized controlled trial of 110 male sex workers in the US Northeast. Individuals randomized to the Stage 1 PrEPare-for-Work Case Management arm were th ree times as likely as those in the standard of care (SOC) arm to initiate PrEP (RR = 2.95, 95% CI = 1.57–5.57). Participan...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
Can Self-affirmation Encourage HIV-Prevention? Evidence from Female Sex Workers in Senegal
AbstractWe test an intervention aiming to increase condom usage and HIV testing in a stigmatized population at high risk of contracting HIV: female sex workers (FSWs) in Senegal. Some sex work is legal in Senegal, and condoms and HIV tests are freely available to registered FSWs —but FSWs may be reluctant to get tested and use condoms, in part because doing so would entail acknowledging their risk of contracting HIV and potentially expose them to stigma. Drawing on self-affirmation theory, we hypothesized that reflecting on a source of personal pride would help participan ts acknowledge their risk of HIV, intend to use c...
Source: AIDS and Behavior - September 23, 2023 Category: Infectious Diseases Source Type: research
Sustainable healthcare is better for patients
Acting on climate change is often framed as having to give stuff up, to cost more money, to make sacrifices. Yet in healthcare we find the opposite can often be true: there are many actions we can take which reduce the carbon footprint of healthcare which actually end up with better outcomes for our patients.
In this episode, we hear from two examples of that. Singing for breathing is a type of social prescribing to help people with chronic lung disease manage their breathlessness, reducing their need to be reliant on healthcare to do this, while also finding joy and a sense of community. Stephen is one patient who has be...
Source: The BMJ Podcast - September 22, 2023 Category: General Medicine Authors: BMJ Group Source Type: podcasts
Mass Spectrometric Profiling of HLA-B44 Peptidomes Provides Evidence for Tapasin-Mediated Tryptophan Editing
J Immunol. 2023 Sep 22:ji2300232. doi: 10.4049/jimmunol.2300232. Online ahead of print.ABSTRACTThe extreme polymorphisms of HLA class I proteins result in structural variations in their peptide binding sites to achieve diversity in Ag presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assembly factor tapasin were assessed for HLA-B*44:05 (Y116) and a close variant, HLA-B*44:02 (D116), which have low and high tapasin dependence, respectively, for their cell surface expression. Analyses of the HLA-B*44:05 peptidomes in the presence and absence of tapasin...
Source: Journal of Immunology - September 22, 2023 Category: Allergy & Immunology Authors: Amanpreet Kaur Avrokin Surnilla Anita J Zaitouna Michael B Mumphrey Venkatesha Basrur Irina Grigorova Marcin Cieslik Mary Carrington Alexey I Nesvizhskii Malini Raghavan Source Type: research
Diagnostic accuracy of a point-of-care urine tenofovir assay, and associations with HIV viraemia and drug resistance among people receiving dolutegravir and efavirenz-based antiretroviral therapy
CONCLUSIONS: Among PLHIV receiving ART, a rapid urine TFV immunoassay can be used to accurately monitor urine TFV levels compared to the gold standard of LC-MS/MS. Undetectable point-of-care urine TFV results were associated with viraemia, particularly among people receiving dolutegravir.TRIAL REGISTRATION: Pan-African Clinical Trials Registry: PACTR202001785886049.PMID:37735860 | DOI:10.1002/jia2.26172
Source: Journal of the International AIDS Society - September 22, 2023 Category: Infectious Diseases Authors: Jienchi Dorward Richard Lessells Katya Govender Pravi Moodley Natasha Samsunder Yukteshwar Sookrajh Phil Turner Christopher C Butler Gail Hayward Monica Gandhi Paul K Drain Nigel Garrett Source Type: research
Recommendations on data sharing in HIV drug resistance research
PLoS Med. 2023 Sep 22;20(9):e1004293. doi: 10.1371/journal.pmed.1004293. Online ahead of print.ABSTRACTAuthor summary • Human immunodeficiency virus (HIV) drug resistance has implications for antiretroviral treatment strategies and for containing the HIV pandemic because the development of HIV drug resistance leads to the requirement for antiretroviral drugs that may be less effective, less well-tolerated, and more expensive than those used in first-line regimens. • HIV drug resistance studies are designed to determine which HIV mutations are selected by antiretroviral drugs and, in turn, how these mutations affect ant...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seth C Inzaule Mark J Siedner Susan J Little Santiago Avila-Rios Alisen Ayitewala Ronald J Bosch Vincent Calvez Francesca Ceccherini-Silberstein Charlotte Charpentier Diane Descamps Susan H Eshleman Joseph Fokam Lisa M Frenkel Ravindra K Gupta John P A Io Source Type: research
Determinants of the unmet needs for information, education and communication on sexual health among single youths in Burundi
Afr J Reprod Health. 2023 Aug 31;27(8):39-37. doi: 10.29063/ajrh2023/v27i8.5.ABSTRACTThe prevalence of HIV/AIDS among young people aged 15-24 in urban areas is at least 12 times higher among girls than boys in Burundi, while it is twice as high in Rwanda. The gap between the two countries could be narrowed if Burundi's single young people were provided with sufficient information about their sexual health through appropriate channels. The aim of this study was to examine the social and individual "determinants" of unmet needs for sexual health information, education and communication (IEC) among unmarried young boys and gi...
Source: African Journal of Reproductive Health - September 22, 2023 Category: African Health Authors: Bahimana Adolphe Mburano Rwenge Jean-Robert Source Type: research
Notice of Change in the Expiration Date for PAR-21-228, "NIMH Research Education Mentoring Program for HIV/AIDS Researchers (R25 Clinical Trial Not Allowed)"
Notice NOT-MH-23-395 from the NIH Guide for Grants and Contracts
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 22, 2023 Category: Research Source Type: funding
Kenya: UNFPA-Led Alliance Unveils Financing for Adolescent-Friendly HIV Testing and Treatment
[Capital FM] Nairobi -- Three UN agencies in the country have announced a collaborative effort to promote adolescent-friendly sexual and reproductive health services in a bid to enhance HIV testing and treatment among the youth.
Source: AllAfrica News: Health and Medicine - September 22, 2023 Category: African Health Tags: HIV-Aids and STDs East Africa External Relations Health and Medicine International Organizations and Africa Kenya Source Type: news
Perception of PrEP-Related Stigma in PrEP Users Perception of PrEP-Related Stigma in PrEP Users
This paper provides insight into how PrEP users perceive PrEP-related stigma and identifies the factors associated with this perception.HIV Medicine
Source: Medscape Today Headlines - September 22, 2023 Category: Consumer Health News Tags: HIV/AIDS Journal Article Source Type: news
Extracellular vesicles as biomarkers for AIDS-associated non-Hodgkin lymphoma risk
In this study, we investigate the association of EVs bearing PD-L1 and molecules important in B-cell activation and differentiation with AIDS-NHL risk.MethodsEVs were isolated from archived serum collected prior to the diagnosis of AIDS-NHL in cases (N = 51) and matched HIV+ controls (N = 52) who were men enrolled in the Los Angeles site of the MACS/WIHS Combined Cohort Study (MWCCS). Serum specimens of AIDS-NHL cases were collected at a mean time of 1.25 years (range of 2 to 36 months) prior to an AIDS-NHL diagnosis. The expression of PD-L1 and other molecules on EVs (CD40, CD40L, TNF-RII, IL-6Rα, B7-H3, ICAM-1, and FasL...
Source: Frontiers in Immunology - September 22, 2023 Category: Allergy & Immunology Source Type: research
