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Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | PMC:PMC10500261 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | PMC:PMC10500257 |...
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
Population prevalence of antiretroviral therapy sharing and its association with HIV viremia in rural Uganda: a cross-sectional population-based study
CONCLUSIONS: ART sharing is common among persons reporting ART use in rural Uganda, particularly among men. Sharing ART was associated with viremia, and receiving ART may facilitate viral suppression. HIV programmes may benefit from considering ART sharing in counselling messages.PMID:37705364 | PMC:PMC10500261 | DOI:10.1002/jia2.26135
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Caitlin E Kennedy Xinyi Feng Robert Ssekubugu Joseph G Rosen Joseph Ssekasanvu Godfrey Kigozi David Serwadda Ping Teresa Yeh Joseph Kagaayi Thomas C Quinn Aaron A R Tobian Maria J Wawer Steven J Reynolds Larry W Chang M Kate Grabowski Fred Nalugoda Source Type: research
Cross-sectional HIV and HCV cascades of care across the regions of Ukraine between 2019 and 2020: findings from the CARE cohort
CONCLUSIONS: Over 98% of PLHIV in care in both CARE sites in Ukraine were receiving ART, and the target of 90% virally suppressed was achieved in persons >6 months on ART. Only one of six HIV/HCV study sites tested over 50% anti-HCV-positive PLHIV for HCV-RNA and treated over 25% of eligible persons. While free HCV-RNA testing and DAA treatment are paramount to achieving HCV elimination targets, they remained a challenge in Ukraine in 2019-2020. The extent of the HIV and HCV care disruption during the war will be further assessed in the CARE cohort and compared with the pre-war findings.PMID:37705358 | PMC:PMC10500257 |...
Source: Journal of the International AIDS Society - September 14, 2023 Category: Infectious Diseases Authors: Olga Fursa Joanne Reekie Ihor Kuzin Larysa Hetman Alina Kryshchuk Olena Starychenko Nana Hrytsaiuk Inna Khodus Alla Nyzhnyk Viktoriia Rakhuba Maryna Kovalevska Tetiana Maistat Iryna Pryhoda Marianna Ahieieva Olena Varvarovska Olena Valdenmaiier Jens Lundg Source Type: research
Ethiopia: Building Bridges to Success - Paving the Path to Sustaining the HIV/Aids Response
[U.S. Embassy Addis Ababa] Benjamin Kasdan, Acting PEPFAR Ethiopia Country Coordinator
Source: AllAfrica News: Health and Medicine - September 14, 2023 Category: African Health Tags: HIV-Aids and STDs East Africa Ethiopia External Relations Governance Health and Medicine Press and Media United States, Canada and Africa Source Type: news
Sexual compulsivity mediates the association between childhood sexual abuse and condom use resistance among men who have sex with men and women - Kirwan M, Stewart R, Chen W, Hammett JF, Davis KC.
Despite the continued prevalence of HIV and condoms' proven effectiveness in HIV prevention, many young men continue to engage in condom use resistance (CUR). Research shows that sexual compulsivity and childhood sexual abuse (CSA) victimization are risk f...
Source: SafetyLit - September 14, 2023 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Sydney’s HIV success shows way for others
Experts say joint effort by clinicians, activists and politicians to deploy preventive tools shows how effective they can be
Source: FT.com - Drugs and Healthcare - September 14, 2023 Category: Pharmaceuticals Source Type: news
In charts: Threat from infectious diseases eases across the world
Illnesses such as cancer and heart disease supplant likes of HIV
Source: FT.com - Drugs and Healthcare - September 14, 2023 Category: Pharmaceuticals Source Type: news
The changing characteristics of a cohort of children and adolescents living with HIV at antiretroviral therapy initiation in Asia
by Johanna Beulah Sornillo, Rossana Ditangco, Aarti Kinikar, Dewi Kumara Wati, Quy Tuan Du, Dinh Qui Nguyen, Vohith Khol, Lam Van Nguyen, Thanyawee Puthanakit, Pradthana Ounchanum, Nia Kurniati, Kulkanya Chokephaibulkit, Thahira A. Jamal Mohamed, Tavitiya Sudjaritruk, Siew Moy Fong, Nagalingeswaran Kumarasamy, Pope Kosalaraksa, Revathy A. Nallusamy, Nik Khairulddin Nik Yusoff, Annette H. Sohn, Azar Kariminia, on behalf of the TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific
Despite improvements in HIV testing and earlier antiretroviral therapy (ART) initiation in children living with HIV through the y...
Source: PLoS One - September 14, 2023 Category: Biomedical Science Authors: Johanna Beulah Sornillo Source Type: research
Viruses, Vol. 15, Pages 1923: Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses
trakova
El-Hage
The protein Beclin1 (BECN1, a mammalian homologue of ATG6 in yeast) plays an important role in the initiation and the normal process of autophagy in cells. Moreover, we and others have shown that Beclin1 plays an important role in viral replication and the innate immune signaling pathways. We previously used the cationic polymer polyethyleneimine (PEI) conjugated to mannose (Man) as a non-viral tool for the delivery of a small interfering (si) Beclin1-PEI-Man nanoplex, which specifically targets mannose receptor-expressing glia (microglia and astrocytes) in the brain when administered intranasally to...
Source: Viruses - September 14, 2023 Category: Virology Authors: Rodriguez Owens Perry Stone Soler Almohtadi Zhao Elena V. Batrakova El-Hage Tags: Article Source Type: research
Engineered CD4 T cells expressing a membrane anchored viral inhibitor restrict HIV-1 through cis and trans mechanisms
In this study, we further characterize the effect of GPI-scFv X5 on cell-cell HIV-1 transmission from DCs to target cells. We report that expression of GPI-scFv X5 in transduced CD4+ cell lines and human primary CD4+ T cells potently restricts viral replication in iDC- or mDC-captured HIV-1 in trans. Using live-cell imaging, we observed that when GPI-GFP or GPI-scFv X5 transduced T cells are co-cultured with iDCs, GPI-anchored proteins enrich in contact zones and subsequently migrate from T cells into DCs, suggesting that transferred GPI-scFv X5 interferes with HIV-1 infection of iDCs. We conclude that GPI-scFv X5 on the s...
Source: Frontiers in Immunology - September 14, 2023 Category: Allergy & Immunology Source Type: research
PEPFAR Reauthorization by Congress Urgent for Global Health
This Viewpoint discusses the importance of the US Congress reauthorizing funding for the President ’s Emergency Plan for AIDS Relief, a program developed in 2003 that has played a critical role in fighting HIV/AIDS worldwide as well as other emerging infections and noncommunicable diseases.
Source: JAMA - Journal of the American Medical Association - September 14, 2023 Category: General Medicine Source Type: research
Tenofovir diphosphate in dried blood spots and HIV-1 resistance in South Africa
Suboptimal antiretroviral (ART) adherence can lead to virologic failure with consequent HIV-1 resistance. Tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) is a powerful biomarker of cumulative adheren...
Source: AIDS Research and Therapy - September 14, 2023 Category: Infectious Diseases Authors: Y. Singh, J. Castillo-Mancilla, R. Madimabe, L. Jennings, C. M. Ferraris, R. N. Robbins, P. L. Anderson, R. H. Remien and C. Orrell Tags: Research Source Type: research
Racial disparities in use of syringe service programs in King County, WA: a comparison of two cross-sectional surveys
Syringe service programs (SSPs) provide tools to people who inject drugs (PWID) to prevent overdose, reduce the risk of HIV and HCV infection, and reduce injection frequency. While effective, previous research...
Source: Harm Reduction Journal - September 14, 2023 Category: Drugs & Pharmacology Authors: Katheryn Salow, Helen E. Jack, Joe Tinsley, Caleb J. Banta-Green, Susan Kingston, Matthew Iles-Shih, Judith I. Tsui and Sara Glick Tags: Research Source Type: research
MicroRNA signature from extracellular vesicles of HCV/HIV co-infected individuals differs from HCV mono-infected
AbstractHepatitis C virus (HCV) coinfection with human immunodeficiency virus (HIV) has a detrimental impact on disease progression. Increasing evidence points to extracellular vesicles (EVs) as important players of the host-viral cross-talk. The microRNAs (miRNAs), as essential components of EVs cargo, are key regulators of normal cellular processes and also promote viral replication, viral pathogenesis, and disease progression. We aimed to characterize the plasma-derived EVs miRNA signature of chronic HCV infected and HIV coinfected patients to unravel the molecular mechanisms of coinfection. EVs were purified and charac...
Source: Journal of Molecular Medicine - September 14, 2023 Category: Molecular Biology Source Type: research
