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This page shows you the latest news and research items in this category.

Comparison of the Efficacy of Dexmedetomidine plus Fentanyl Patient-controlled Analgesia with Fentanyl Patient-controlled Analgesia for Pain Control in Uterine Artery Embolization for Symptomatic Fibroid Tumors or Adenomyosis: A Prospective, Randomized Study
Abstract: Purpose: To investigate whether dexmedetomidine infusion could reduce opioid consumption and opioid-related side effects after uterine artery embolization (UAE).Materials and Methods: Fifty patients undergoing UAE for symptomatic leiomyomas or adenomyosis were randomized into two groups. In 25 patients, dexmedetomidine infusion was started at 0.2 μg/kg/h at 30 minutes before the procedure, followed by 0.4 μg/kg/h for 6 hours after the procedure. In another 25 patients (control group), volume-matched normal saline solution was administered. Both groups received fentanyl-based intravenous patient-controlled analg...
Source: Journal of Vascular and Interventional Radiology : JVIR - May 25, 2013 Category: Radiology Authors: So Yeon Kim, Chul Ho Chang, Jong Seok Lee, Yoon Jae Kim, Man Deuk Kim, Dong Woo Han Source Type: research

Second trimester medical abortion in a woman with prior classical caesarean section and a uterine leiomyoma - A case report.
Conclusions An early second trimester medical abortion with misoprostol was successfully performed in a woman with prior classical CS and a large uterine leiomyoma. PMID: 23692523 [PubMed - as supplied by publisher] (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - May 22, 2013 Category: Reproduction Medicine Authors: Seto MT, Ngu SF, Cheung VY, Pun TC Tags: Eur J Contracept Reprod Health Care Source Type: research

Gene expression analysis reveals an angiogenic profile in uterine leiomyoma pseudocapsule
In this study, quantitative RT–PCR analysis was performed on 18 matched PC, UL and UM specimens and results showed that the PC displays a specific gene expression profile. The low expression level of insulin-like growth factor (IGF-2), a fibroid specific marker, that we found in the PC and the UM when compared with the UL, clearly indicates that the PC is in structural continuity with the UM. However, the significant increase in endoglin expression level in PC with respect to the UL and UM indicates that an active neoangiogenesis is present in PC. Conversely, other angiogenic factors such as von Willebrand factor (vW...
Source: Molecular Human Reproduction - May 16, 2013 Category: Molecular Biology Authors: Di Tommaso, S., Massari, S., Malvasi, A., Bozzetti, M. P., Tinelli, A. Tags: Articles Source Type: research

Successful surgical removal of an intravenous leiomyoma extending to the right atrium 4 years after hysterectomy [IMAGES IN CARDIO-THORACIC SURGERY]
(Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kikuchi, C., Asami, F., Hanzawa, K., Tsuchida, M. Tags: IMAGES IN CARDIO-THORACIC SURGERY Source Type: research

Ligation-assisted endoscopic enucleation for the diagnosis and resection of small gastrointestinal tumors originating from the muscularis propria: a preliminary study
Conclusions: EE-L appears to be a safe, effective, and relatively simple method for the histologic diagnosis and removal of small gastrointestinal tumors originating from the muscularis propria. (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - May 16, 2013 Category: Gastroenterology Authors: Jintao GuoZhijun LiuSiyu SunSheng WangNan GeXiang LiuGuoxin WangXianghong Yang Source Type: research

Self-reported family history of leiomyoma: not a reliable marker of high risk
Conclusions: Many women may first learn about their family history of fibroids when discussing their own clinical diagnosis with family members. Such bias would invalidate self-reported family history as a predictor of fibroid risk. As new pharmacologic treatments for fibroids are developed, women at high risk of fibroids would benefit from early screening and pharmacologic treatment to delay development of large fibroids and reduce the need for invasive treatments. Self-reported family history is not useful for identifying high-risk women. (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - May 1, 2013 Category: Epidemiology Authors: Tina Marie Saldana, Malana Moshesh, Donna Day Baird Source Type: research

Self-reported family history of leiomyoma: not a reliable marker of high risk.
CONCLUSIONS: Many women may first learn about their family history of fibroids when discussing their own clinical diagnosis with family members. Such bias would invalidate self-reported family history as a predictor of fibroid risk. As new pharmacologic treatments for fibroids are developed, women at high risk of fibroids would benefit from early screening and pharmacologic treatment to delay development of large fibroids and reduce the need for invasive treatments. Self-reported family history is not useful for identifying high-risk women. PMID: 23621994 [PubMed - in process] (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - May 1, 2013 Category: Epidemiology Authors: Saldana TM, Moshesh M, Baird DD Tags: Ann Epidemiol Source Type: research

Cytokine Patterns Differ Seasonally between Women with and without Uterine Leiomyomata
ConclusionsThese data suggest that new insight into leiomyoma formation may be acquired through investigation of the immune system. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - April 25, 2013 Category: Allergy & Immunology Authors: Ganesa Wegienka, Donna Day Baird, Tracy Cooper, Kimberley J. Woodcroft, Suzanne Havstad Tags: Original Article Source Type: research

Cotyledonoid dissecting leiomyoma treated by laparoscopic surgery: A case report
Abstract A cotyledonoid dissecting leiomyoma is categorized as a leiomyoma with an unusual growth pattern, which is characterized by remarkable extrauterine bulbous growth in continuity with a dissecting myometrial component. A 36‐year‐old patient was preoperatively diagnosed with a mature cystic teratoma of the left ovary, and according to MRI, the tumor protruded from the uterus into the right broad ligament and was 10 cm in diameter. She underwent laparoscopic surgery to resect ovarian teratoma and the tumor under the right broad ligament. The tumor was almost completely resected and diagnosed as a cotyledonoid di...
Source: Asian Journal of Endoscopic Surgery - April 22, 2013 Category: Surgery Authors: Hirohiko Tanaka, Kuniaki Toriyabe, Tokihiro Senda, Yasufumi Sakakura, Kayo Yoshida, Tetsuo Asakura, Haruki Taniguchi, Kenji Nagao Tags: Case Report Source Type: research

Hysteroscopic Enucleation of Type II Submucosal Uterine Leiomyomas Using a TRUCLEAR Hysteroscopic Morcellator: Case Report and Review of the Literature
Journal of Laparoendoscopic & Advanced Surgical Techniques Apr 2013, Vol. 23, No. 4: 378-382. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - April 10, 2013 Category: Surgery Tags: article Source Type: research

EMAS clinical guide: Assessment of the endometrium in peri and postmenopausal women
Abstract: Introduction: Invasive as well as non-invasive methods are available for assessment of the endometrium.Aims: The purpose of this clinical guide is to provide evidence-based advice on endometrial assessment in peri and postmenopausal women.Material and methods: Literature review and consensus of expert opinion.Results and conclusions: Presuming speculum examination and cervical cytology are assessed, transvaginal ultrasound should be undertaken initially as it is non-invasive and will not only measure endometrial thickness, but will also detect other pelvic pathology such as leiomyomas and ovarian tumours.The main...
Source: Maturitas - April 8, 2013 Category: Primary Care Authors: Eva Dreisler, Lars Grønlund Poulsen, Sofie Leisby Antonsen, Iuliana Ceausu, Herman Depypere, C. Tamer Erel, Irene Lambrinoudaki, Faustino R. Pérez-López, Tommaso Simoncini, Florence Tremollieres, Margaret Rees, Lian G. Ulrich Tags: EMAS clinical guide Source Type: research

Is Uterine Artery Embolization for Patients with Large Myomas Safe and Effective? A Retrospective Comparative Study in 323 Patients
Conclusions: UAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE. (Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - April 8, 2013 Category: Radiology Authors: Hye Jeong Choi, Gyeong Sik Jeon, Man Deuk Kim, Jong Tae Lee, Jung Hyun Yoon Source Type: research

[Orbital leiomyoma. Case report and review of the literature.]
We report an intraconal orbital haemangioleiomyoma in a 55-year-old female treated by total resection through fronto-orbital craniotomy, with no recurrence after 15 months of follow-up. Radiological and pathological features are discussed, emphasising the prognostic role of the surgery. PMID: 23562416 [PubMed - as supplied by publisher] (Source: Neurocirugia)
Source: Neurocirugia - April 3, 2013 Category: Neurosurgery Authors: González-Martínez E, Robla Costales J, Fernández Fernández J, Viñuela Lobo J, Santamarta D, Lomas García J, Iglesias E, Ribas Ariño T, García-Cosamalón J Tags: Neurocirugia (Astur) Source Type: research

Association Between Esophageal Leiomyomatosis and p53 Mutation [CASE REPORTS]
Li-Fraumeni syndrome is a cancer predisposition syndrome associated with a variety of neoplasms, mainly soft tissue sarcoma, premenopausal breast cancer, brain tumors, adrenocortical carcinoma, and leukemia. Esophageal leiomyomatosis involves the presence of several rare benign neoplastic lesions composed of proliferating smooth muscle cells in the esophageal wall. The current case report presents a patient with recurrent diffuse leiomyomas of the esophagus and confirmed p53 mutation with clinical criteria of Li-Fraumenilike syndrome. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 31, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kazarin, O., Vlodavsky, E., Guralnik, L., Kremer, R., Lachter, J., Bar-Sela, G. Tags: Esophagus - other CASE REPORTS Source Type: research

Atypical pilar leiomyomatosis: an unusual presentation of multiple atypical cutaneous leiomyomas
We report a case of multiple cutaneous atypical leiomyomas occurring in a 43‐year‐old man with long history of lesions of the right lower leg and a family history of leiomyomatosis. Twenty of the lesions were excised due to pain and were examined histopathologically. All the lesions exhibited features described in atypical leiomyomas of the skin including increased cellularity, nuclear atypia and pleomorphism, and low mitotic activity. The biologic potential of cutaneous atypical leiomyomas is uncertain. Only a few case reports exist in the literature with the majority occurring as solitary lesions. Most of the reporte...
Source: Journal of Cutaneous Pathology - March 29, 2013 Category: Pathology Authors: Deborah L. Cook, Melissa A. Pugliano‐Mauro, Zea L. Schultz Tags: Case Report Source Type: research

Haemophilus influenzae acute endometritis with bacteremia: case report and literature review
Abstract: Haemophilus influenzae rarely causes acute endometritis and the few published cases have always been associated with intrauterine devices (IUD). A 48-year-old female presented to the emergency department with a 3-day history of lower abdominal pain and fever. On physical examination she was tachycardic, hypotensive and had fundic tenderness to palpation. Imaging showed uterine leiomyomas and no IUD. Blood cultures grew a non-typable H. influenzae. Endometrial biopsy demonstrated acute endometritis. Tissue Gram stains and cervico-vaginal cultures were negative; however, polymerase chain reaction (PCR) determined p...
Source: Diagnostic Microbiology and Infectious Disease - March 27, 2013 Category: Microbiology Authors: David Martin, Reema H. Dbouk, Marlene DeLeon-Carnes, Carlos del Rio, Jeannette Guarner Tags: Case Reports Source Type: research

Three cases of intraocular mesectodermal leiomyoma expressing progesterone and androgen receptors
I G Rennie, P A Rundle & H S Mudhar (Source: Eye)
Source: Eye - March 22, 2013 Category: Opthalmology Authors: H Quhill Tags: mexectodermal leiomyoma androgen receptor progesterone receptor Source Type: research

Myomectomy during cesarean delivery
Conclusions: Cesarean myomectomy may be a reasonable option for some women with leiomyoma. However, no definite conclusion can be drawn because the data included in the meta-analysis were of low quality. (Source: International Journal of Gynaecology and Obstetrics)
Source: International Journal of Gynaecology and Obstetrics - March 18, 2013 Category: OBGYN Authors: Dianrong Song, Wei Zhang, Mark C. Chames, Jie Guo Tags: Review Article Source Type: research

Unilateral multi-segmental leiomyomas: A report of rare case
Chandramohan Kudligi, Binod K Khaitan, Pradeep Vittal Bhagwat, Dinesh Prasad AsatiIndian Journal of Dermatology 2013 58(2):160-160A 30-year-old female presented to us with multiple tender erythematous papules and nodules. These lesions showed multi-segmental distribution along 5 th cervical, 6 th dorsal, and 1 st sacral segments of right half of the body. Histopathological examination confirmed the clinical diagnosis of leiomyoma. Patient was started on nifedipine 10 mg thrice-daily with significant symptomatic improvement in 3 months. Though segmental distribution of leiomyoma is common, unilateral multi-segmental distrib...
Source: Indian Journal of Dermatology - March 5, 2013 Category: Dermatology Authors: Chandramohan KudligiBinod K KhaitanPradeep Vittal BhagwatDinesh Prasad Asati Source Type: research

Congenital leiomyoma of the distal ileum associated with ileal atresia: A case report
Abstract: Association of distal ileal atresia with leiomyoma is a quite rare condition. Herein, we describe a newborn who underwent surgery for ileal atresia and was found to have leiomyoma on pathological examination in the atretic segment. The presence of leiomyoma may indicate a malformation during recanalization and could play a role in the etiology of intestinal atresia. Thus, some cases of atresia may be due to tumor (leiomyoma) in the bowel wall. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 1, 2013 Category: Surgery Authors: Emine Ince, Pelin Oğuzkurt, Emine Tuba Canpolat, Abdulkerim Temiz, Akgun Hiçsönmez Tags: Journal of Pediatric Surgery Electronic Pages (Available only online at www.jpedsurg.org) Source Type: research

MED12 exon 2 mutations in histopathological uterine leiomyoma variants
52;tzow & Lauri A Aaltonen (Source: European Journal of Human Genetics)
Source: European Journal of Human Genetics - February 27, 2013 Category: Genetics & Stem Cells Authors: Netta MäkinenPia VahteristoKati KämpjärviJohanna ArolaRalf BützowLauri A Aaltonen Tags: uterine fibroid uterine leiomyoma variants MED12 FH Source Type: research

Phosphohistone‐H3 And Ki‐67 Immunostaining In Cutaneous Pilar Leiomyoma And Leiomyosarcoma (Atypical Intradermal Smooth Muscle Neoplasm)
ConclusionPHH3 immunostain can simplify counting of mitotic figures in cutaneous smooth muscle neoplasms, especially those with many pyknotic nuclei, and may help to reduce interobserver variability. Ki‐67 staining may also be of help in establishing a diagnosis of LMS. (Source: Journal of Cutaneous Pathology)
Source: Journal of Cutaneous Pathology - February 26, 2013 Category: Pathology Authors: Munir H Idriss, Viktoryia Kazlouskaya, Saurabh Malhotra, Christian Andres, Dirk Elston Tags: Original Article Source Type: research

Atypical pilar leiomyomatosis – An unusual presentation of multiple atypical cutaneous leiomyomas
We report a case of multiple cutaneous atypical leiomyomas occurring in a 43‐year‐old man with long history of lesions of the right lower leg and a family history of leiomyomatosis. Twenty of the lesions were excised due to pain and were examined histopathologically. All of the lesions exhibited features described in atypical leiomyomas of the skin including increased cellularity, nuclear atypia and pleomorphism, and low mitotic activity. The biologic potential of cutaneous atypical leiomyomas is uncertain. Only a few case reports exist in the literature with the majority occurring as solitary lesions. Most of the repo...
Source: Journal of Cutaneous Pathology - February 24, 2013 Category: Pathology Authors: Deborah L. Cook, Melissa A. Pugliano‐Mauro, Zea L. Schultz Tags: Case Report Source Type: research

Mixed endometrial stromal and smooth muscle tumor of the uterus: case report
We describe a case of a patient who had been previously diagnosed with uterine leiomyoma, and after surgery, the anatomopathological study revealed a mixed tumor of uterine smooth muscle and endometrial stromal cells. (Source: Jornal Brasileiro de Patologia e Medicina Laboratorial)
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - February 23, 2013 Category: Pathology Source Type: research

'I had to help my child!':: The role of emotions, risk, and trust in use of nasal decongestants in children
Recent studies suggest that a number of common cold medicines, including nasal decongestants are not suitable for small children. In Latvia nasal decongestants are primarily over-the-counter (OTC) medicines, and patient information leaflets generally permit use of these medicines for small children. The previous studies in Latvia investigating the use of medicines in cases of common cold demonstrated extensive use of decongestants in children less than six years of age, marking a necessity for more profound research. As a result a qualitative study was implemented in 2011 to identify sources of information that offer advic...
Source: Journal of Child Health Care - March 1, 2013 Category: Pediatrics Authors: Salmane-Kulikovska, I., Mezinska, S. Tags: Articles Source Type: research

Ischemic Stroke Related to Severe Iron-Deficiency Anemia in Adults May Benefit from Blood Transfusion (P01.232)
CONCLUSIONS: Prevalence of IDA is 1-20%; it is 3.9% in our AIS population and is often related to untreated uterine bleeding. As described in the pediatric population, severe IDA may be an underlying mechanism of ischemic stroke in adults, therefore, efforts must be undertaken to identify and treat the cause of the anemia. While patients with AIS and severe IDA may receive TPA, blood transfusion may be considered as an adjuvant therapy.Supported by: SPOTRIAS P50 NS044227 & NIH Training Grant 5T 32NS0077412-12.Disclosure: Dr. Choi has nothing to disclose. Dr. Sanchez-Rotunno has nothing to disclose. Dr. Gonzales has not...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choi, E., Sanchez-Rotunno, M., Gonzales, N. Tags: P01 Cerebrovascular Disease I Source Type: research

Uterine Leiomyoma: Available Medical Treatments and New Possible Therapeutic Options.
Conclusion:To date, several pathogenetic factors such as genetic factors, epigenetic factors, estrogens, progesterone, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in leiomyoma development and growth. On the basis of current hypotheses, several medical therapies have been investigated. GnRH agonist has been approved by US Food and Drug Administration for reducing fibroid volume and related symptoms. In addition, the FDA also approved an intrauterine device, levonorgestrel-releasing intrauterine system (Mirena), for additional use to treat heavy menstrual bleeding in intrau...
Source: The Journal of Clinical Endocrinology and Metabolism - February 7, 2013 Category: Endocrinology Authors: Islam MS, Protic O, Giannubilo SR, Toti P, Tranquilli AL, Petraglia F, Castellucci M, Ciarmela P Tags: J Clin Endocrinol Metab Source Type: research

No REST for fibroids [Developmental Biology]
Good news: A long-awaited model for uterine fibroid tumor research is upon us (1). Historically, there has been a paucity of in vivo models for the study of fibroid tumors (i.e., leiomyomas), benign female pelvic organ tumors characterized by clonal proliferation of smooth muscle cells and expression of genes involved... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 5, 2013 Category: Science Authors: Rueda, B. R., Davis, J. S. Tags: Commentaries Source Type: research

Loss of REST in leiomyomas [Developmental Biology]
Uterine fibroids (leiomyomas) are the most common tumors of the female reproductive tract, occurring in up to 77% of reproductive-aged women, yet molecular pathogenesis remains poorly understood. A role for atypically activated mammalian target of rapamycin (mTOR) pathway in the pathogenesis of uterine fibroids has been suggested in several studies.... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - February 5, 2013 Category: Science Authors: Varghese, B. V., Koohestani, F., McWilliams, M., Colvin, A., Gunewardena, S., Kinsey, W. H., Nowak, R. A., Nothnick, W. B., Chennathukuzhi, V. M. Tags: Biological Sciences Source Type: research

Differential clinical and pathological characteristics of esophageal stromal tumors and leiomyomata
The objective of the study was to assess the differences in clinical and pathological characteristics between esophageal stromal tumor and leiomyoma. Data from 93 esophageal stromal tumors and leiomyomata cases were retrospectively analyzed, including clinical symptoms, endoscopic features, pathological characteristics, immunohistochemistry (IHC), and treatment. All cases underwent endoscopic ultrasonography examination before treatment. Lesions arising from the muscularis mucosa were resected by endoscopic mucosal resection or endoscopic submucosal dissection. Lesions arising from the muscularis propria were resected by s...
Source: Diseases of the Esophagus - February 5, 2013 Category: Gastroenterology Authors: B.‐Y. Fei, J.‐M. Yang, Z.‐S. Zhao Tags: Original Article Source Type: research

A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies.
Abstract The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions (23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7.8%), 68 candidiasis (7.5%), 35 benign ulcer (3.8%), 41 squamous papilloma (4.5%), 4 granular cell tum...
Source: International Journal of Clinical and Experimental Pathology - February 2, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Pyomyoma after uterine artery embolization.
CONCLUSION: : Surgical management of pyomyoma may be necessary early in the management of pyomyoma after uterine artery embolization. PMID: 23344399 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - February 1, 2013 Category: OBGYN Authors: Rosen ML, Anderson ML, Hawkins SM Tags: Obstet Gynecol Source Type: research

Retract-ligate-unroof-biopsy: a novel approach to the diagnosis and therapy of large nonpedunculated stromal tumors (with video)
Conclusions: The RLUB technique is feasible as a platform for full-thickness treatment of stromal tumors. Limitations encountered included technical challenges and delayed bleeding. Further developmental work is needed. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 31, 2013 Category: Gastroenterology Authors: Kenneth F. Binmoeller, Janak N. Shah, Yasser M. Bhat, Steve D. Kane Tags: Clinical Endoscopy Source Type: research

Acute abdomen caused by huge pedunculated uterine leiomyoma in torsion
(Source: ANZ Journal of Surgery)
Source: ANZ Journal of Surgery - January 27, 2013 Category: Surgery Authors: Goran Šantak, Željko Glavić, Ljubo Begić, Damir Šimleša, Goran Zukanović Tags: LETTER TO THE EDITOR Source Type: research

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours
ConclusionsAmong uterine smooth muscle tumours, MED12 mutations are frequently present in conventional leiomyomas, but are significantly less common in histological variants of leiomyoma and leiomyosarcoma. In contrast to uterine lesions, none of the extrauterine smooth muscle tumours had MED12 mutations. (Source: Histopathology)
Source: Histopathology - January 24, 2013 Category: Pathology Authors: Akiko Matsubara, Shigeki Sekine, Masayuki Yoshida, Akihiko Yoshida, Hirokazu Taniguchi, Ryoji Kushima, Hitoshi Tsuda, Yae Kanai Tags: Short Report Source Type: research

Bladder Leiomyoma
A 76-year-old female presented with left hip pain radiating down the left leg. Pelvic magnetic resonance imaging (MRI) without contrast demonstrated a 4.3 cm homogeneous well marginated bladder dome or bladder wall mass (). Review of systems revealed only a remote history of mild pelvic discomfort 2 years earlier, and the patient denied any urinary tract symptoms or hematuria. Cystoscopy revealed a smooth indentation at the bladder dome with intact urothelium, suggesting a mass either external to the bladder or arising from the bladder wall. Urine cytology was negative for malignant cells. (Source: The Journal of Urology)
Source: The Journal of Urology - January 21, 2013 Category: Urology & Nephrology Authors: Rakhee Goel, Chakradhar R. Thupili Tags: Radiology Page Source Type: research

Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
Summary: Sirtuin, silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1 (SIRT1), is a protein that has been implicated in multiple mammalian functions including cell aging, stress resistance, and differentiation. SIRT1 has also been shown to be involved in multiple tumors. In addition, new pharmacotherapies have recently been approved that target SIRT1. The purpose of this study was to use immunohistochemistry to characterize SIRT1 protein expression in human soft tissue neoplasms with the hopes of finding new diagnostic and therapeutic modalities. SIRT1 immunoreactivity was reviewed in a series of...
Source: Human Pathology - January 17, 2013 Category: Pathology Authors: Brendan C. Dickson, Nicole D. Riddle, John S. Brooks, Theresa L. Pasha, Paul J. Zhang Tags: Original Contributions Source Type: research

Hereditary papillary renal cell carcinoma primarily diagnosed in a cervical lymph node: a case report of a 30-year-old woman with multiple metastases
Conclusion: Papillary renal cell carcinoma in young patients should be further investigated for a hereditary variant like the hereditary leiomyomatosis and renal cell carcinoma even if leiomyomas could not be detected. A detailed histological examination and search for mutations is essential for the survival of patients and relatives. (Source: BMC Urology - Latest articles)
Source: BMC Urology - Latest articles - January 15, 2013 Category: Urology & Nephrology Authors: Carl Ludwig BehnesChristina SchlegelMoneef ShoukierIsabella MagieraFrank HenschkeAlexander SchwarzFelix BremmerHagen Loertzer Source Type: research

Vascular leiomyoma of the lung arising from pulmonary artery.
Abstract Leiomyoma of the lung is extremely rare. The entity is not described in WHO blue book. Less than 100 cases of leiomyoma of the lung have been reported in the literature. However, vascular leiomyoma has not been reported in the literature, to the author's best knowledge. Herein reported is the first case of vascular leiomyoma of the lung arising from smooth muscles of the pulmonary artery. A 62-year-old woman (non-smoker) was found to have a small tumor in the upper lobe in the right lung in routine check. Imaging modalities including CT demonstrated no metastatic lesions. Although clinical cytology and bio...
Source: International Journal of Clinical and Experimental Pathology - January 14, 2013 Category: Pathology Authors: Terada T Tags: Int J Clin Exp Pathol Source Type: research

Progesterone Action in Endometrial Cancer, Endometriosis, Uterine Fibroids, and Breast Cancer.
Abstract Progesterone receptor (PR) mediates the actions of the ovarian steroid progesterone, which together with estradiol regulates gonadotropin secretion, prepares the endometrium for implantation, maintains pregnancy, and differentiates breast tissue. Separation of estrogen and progesterone actions in hormone-responsive tissues remains a challenge. Pathologies of the uterus and breast, including endometrial cancer, endometriosis, uterine fibroids, and breast cancer, are highly associated with estrogen, considered to be the mitogenic factor. Emerging evidence supports distinct roles of progesterone and its influ...
Source: ENDOCR REV - January 9, 2013 Category: Endocrinology Authors: Kim JJ, Kurita T, Bulun SE Tags: Endocr Rev Source Type: research

DOG1 immunoreactivity in uterine leiomyosarcomas
Conclusions Since GISTs have rarely been described as primary uterine neoplasms, the presence of DOG1 immunoreactivity in a uterine leiomyosarcoma may result in diagnostic confusion, and a panel of markers is necessary for diagnosis. Uterine leiomyosarcomas should be added to the list of mesenchymal neoplasms which may be DOG1 positive. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 23, 2012 Category: Pathology Authors: Sah, S. P., McCluggage, W. G. Tags: Immunology (including allergy), Gynecological cancer Original articles Source Type: research

Degeneration of leiomyoma in patients referred for uterine fibroid embolization: incidence, imaging features and clinical characteristics.
Conclusion: The incidence of degeneration of leiomyoma in patients referred for UFE was 5.1%. Patients presented with variable clinical symptoms with or without a history of pregnancy. MR imaging showed a high SI on T1WI and various SIs on T2WI without contrast enhancement. An understanding of the degeneration of leiomyomata is essential when considering UFE. PMID: 23225822 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - December 21, 2012 Category: Universities & Medical Training Authors: Han SC, Kim MD, Jung DC, Lee M, Lee MS, Park SI, Won JY, Lee do Y, Lee KH Tags: Yonsei Med J Source Type: research

Completely infarcted smooth muscle tumor of the placental membrane
We report leiomyoma of the placental membrane, which was discovered on cesarean section. Histologically, the tumor was a benign leiomyoma with complete necrosis, and this finding was confirmed immunohistochemically. Only six cases of smooth muscle tumors of the placenta have been reported to date. This is the third report of leiomyoma involving the placental membrane. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - December 21, 2012 Category: OBGYN Authors: Hacer Haltas, Reyhan Bayrak, Sibel Yenidunya, Hatice Tevrizci Tags: Case Report Source Type: research

Human prolyl hydroxylase expression in uterine leiomyoma during the menstrual cycle
Conclusions: These results suggest that increased expression of PH might play an role in the physiology of uterine leiomyoma during the menstrual cycle. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - December 17, 2012 Category: Endocrinology Authors: Masaaki IwahashiYasuteru MuragakiKazuhiko Ino Source Type: research

Adrenal Nodular Hyperplasia in Hereditary Leiomyomatosis and Renal Cell Cancer
Conclusions: Unilateral and bilateral adrenal nodular hyperplasia was detected in a subset of patients with hereditary leiomyomatosis and renal cell carcinoma. A functional endocrine evaluation is recommended when an adrenal lesion is discovered. Imaging frequently reveals lesions that are not typical of adenomas and positron emission tomography may be positive. To date no patient has had adrenal malignancy, and active surveillance of hereditary leiomyomatosis and renal cell carcinoma adrenal nodules appears justified. (Source: The Journal of Urology)
Source: The Journal of Urology - December 17, 2012 Category: Urology & Nephrology Authors: Brian Shuch, Christopher J. Ricketts, Cathy D. Vocke, Vladimir A. Valera, Clara C. Chen, Rabi Gautam, Gopal N. Gupta, Gabriela S. Gomez Macias, Maria J. Merino, Gennady Bratslavsky, W. Marston Linehan Tags: Oncology: Adrenal/Renal/Upper Tract/Bladder Source Type: research

Familial leiomyomatosis cutis affecting nine family members in two successive generations including four cases of Reed's syndrome
We report here a case of a 53-year-old woman who presented to us with multiple painful nodules over different parts of her body. Based on the histopathological examination, imaging, and past medical records, a diagnosis of Reed's syndrome was made. Three of her sisters had similar disease. Subsequently, it was found that a total of nine members of their family in two successive generations were affected with cutaneous leiomyomas. The present case series has been reported for its interesting clinical presentations and rarity. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - December 14, 2012 Category: Dermatology Authors: Rajesh Kumar MandalSankha KoleySabyasachi BanerjeeSankar Prasad KabirajSudip Kumar GhoshPiyush Kumar Source Type: research

Polymorphism of catechol-o-methyltransferase and uterine leiomyoma.
Abstract Uterine leiomyoma (ULM) is the most common gynecological benign tumor that is affecting around 20-50 % of women over the age of 30. Although its molecular pathogenesis is still unknown, ULM has a multifactorial etiology determined by both genetics and environmental factors. The present study was designed to find out whether Val158Met polymorphism in the catechol-o-methyltransferase (COMT) gene is associated with the risk of ULM. We analyzed COMT Val158Met polymorphism in 105 ULMs patients and 105 healthy subjects using a polymerase chain reaction-based restriction fragment length polymorphism assay. We fo...
Source: Molecular and Cellular Biochemistry - December 14, 2012 Category: Biochemistry Authors: Ates O, Demirturk F, Toprak M, Sezer S Tags: Mol Cell Biochem Source Type: research

Pulmonary benign metastasizing leiomyoma: a case report and review of the literature
Pulmonary benign metastasizing leiomyoma characterized by the growth of uterine leiomyoma in the lung is a very rare disease. We herein report the case of a 46-year-old asymptomatic woman who underwent a total abdominal hysterectomy for her multiple uterine leiomyomas 5 years ago, with the presence of multiple shadows in her chest roentgenogram during the regular check-up. Chest computerized tomography (CT) showed multiple solitary nodules in both lungs. Video-assisted thoracoscopic surgery with a wedge resection of the lesion was performed. Histopathologically, the pulmonary nodule was composed of benign smooth muscle cel...
Source: World Journal of Surgical Oncology - December 12, 2012 Category: Cancer & Oncology Authors: Yili FuHui LiBo TianBin Hu Source Type: research

Pulmonary sclerosing hemangioma presenting with dense spindle stroma cells: a potential diagnostic pitfall
Pulmonary sclerosing hemangioma (PSH) is an uncommon pulmonary tumor. Histologically,PSH typically consists of two types of cells, surface cuboidal cells and polygonal cells, fourarchitectural patterns including papillary, sclerotic, solid, and hemorrhagic. Herein, wepresent a case of PSH in a 59-year-old Chinese female. The tumor was predominantlycomposed of solid area presenting with diffuse spindle cells rather than polygonal cells.Focally, classical papillary and sclerotic area could be seen. Immunohistochemical stainingshowed that the spindle cells were positive for TTF-1, EMA, Actin(SM) and Vimentin, andnegative for ...
Source: Diagnostic Pathology - December 10, 2012 Category: Pathology Authors: Xu-Yong LinYan WangChui-Feng FanYang LiuJuan-Han YuShun-Dong DaiLiang WangEn-Hua Wang Source Type: research