Lobular Carcinoma This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Notice of Correction
Re: Tzao C, Hsu H-S, Sun G-H, Lai H-L, Wang Y-C, Tung H-J, et al. Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma. J Thorac Cardiovasc Surg. 2005;130:1371-7. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - June 18, 2013 Category: Cardiovascular & Thoracic Surgery Tags: Notice of Correction Source Type: research

Low RIN1 Expression in HCC Is Associated With Tumor Invasion and Unfavorable Prognosis.
Conclusions: Our results demonstrate that RIN1 suppresses tumor invasion in HCC patients and that a poor prognosis for HCC is expected when RIN1 expression is downregulated. PMID: 23765536 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2013 Category: Pathology Authors: He H, Wu G, Liu H, Cheng Y, Yu Y, Wang Y, Liu Y Tags: Am J Clin Pathol Source Type: research

Epithelial-mesenchymal transition markers in the differential diagnosis of gastroenteropancreatic neuroendocrine tumors.
Conclusions: β-Catenin and N-cadherin immunohistochemical detection might be a useful tool in the differential diagnosis of small-cell vs large-cell G3 neuroendocrine carcinomas. High Snail1 and Foxc2 expression is associated with the invasion and metastatic spread of GEP NETs. PMID: 23765535 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2013 Category: Pathology Authors: Galván JA, Astudillo A, Vallina A, Fonseca PJ, Gómez-Izquierdo L, García-Carbonero R, González MV Tags: Am J Clin Pathol Source Type: research

Cervical screening test results associated with 265 histopathologic diagnoses of cervical glandular neoplasia.
Conclusions: Conservative cytologic screening practices and HPV cotesting can facilitate early diagnoses of CGN. PMID: 23765533 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - June 18, 2013 Category: Pathology Authors: Zhao C, Li Z, Austin RM Tags: Am J Clin Pathol Source Type: research

Tumor Thrombus
A 48-year-old nonsmoking woman presented with acute epigastric pain after several months of nocturnal sweats. Computed tomography revealed a 9-cm right renal mass with venous tumor thrombus extending from the right renal vein to the right atrium, with no pulmonary embolism and no evidence of distant metastasis. Intraoperative transesophageal echocardiogram demonstrated an 8- × 4-cm echogenic mass (TT) recoiling into the right atrium in systole (A, Online Video 1) and prolapsing into the right ventricle (RV) in diastole (B), with an intact tricuspid valve (Online Video 2). The mass prolapsed into the right ventricular ou...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 17, 2013 Category: Cardiology Source Type: research

Whole exome sequencing of adenoid cystic carcinoma
Adenoid cystic carcinoma (ACC) is a rare malignancy that can occur in multiple organ sites and is primarily found in the salivary gland. While the identification of recurrent fusions of the MYB-NFIB genes have begun to shed light on the molecular underpinnings, little else is known about the molecular genetics of this frequently fatal cancer. We have undertaken exome sequencing in a series of 24 ACC to further delineate the genetics of the disease. We identified multiple mutated genes that, combined, implicate chromatin deregulation in half of cases. Further, mutations were identified in known cancer genes, including PIK3C...
Source: Journal of Clinical Investigation - June 17, 2013 Category: Biomedical Science Authors: Philip J. Stephens, Helen R. Davies, Yoshitsugu Mitani, Peter Van Loo, Adam Shlien, Patrick S. Tarpey, Elli Papaemmanuil, Angela Cheverton, Graham R. Bignell, Adam P. Butler, John Gamble, Stephen Gamble, Claire Hardy, Jonathan Hinton, Mingming Jia, Alagu Source Type: research

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming
Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog–nuclear factor I/B (MYB-NFIB) gene fusion that activates MYB transcriptional regulatory activity. A new study in this issue by Stephens et al. is a comprehensive genomic mutation profiling analysis of this neoplasm and documents a common theme of alteration in chromatin regulatory genes. Also, mutations in SPEN (split ends, homolog of Drosophila), which encodes an RNA-binding coregulatory protein, suggest that other changes in transcriptional regulation may invol...
Source: Journal of Clinical Investigation - June 17, 2013 Category: Biomedical Science Authors: Henry F. Frierson Jr., Christopher A. Moskaluk Source Type: research

Lymphadenectomy combined with locoregional treatment for multiple advanced hepatocellular carcinoma with lymph node metastases.
Abstract Lymphadenectomy of lymph node metastasis (LNM) from hepatocellular carcinoma (HCC) may potentially improve survival of patients with intrahepatic tumors controllable by means of locolegional treatment. However, the treatment strategy has not gained wide clinical acceptance, especially in patients with multiple advanced HCC. Thus, the purpose of this study is to evaluate the role of lymphadenectomy combined with locoregional treatment for the management of multiple advanced HCC with LNM. Between January 1998 and August 2012, 15 patients underwent a selective lymphadenectomy either concurrently or sequential...
Source: Kobe J Med Sci - June 17, 2013 Category: Journals (General) Authors: Awazu M, Fukumoto T, Takebe A, Ajiki T, Matsumoto I, Kido M, Tanaka M, Kuramitsu K, Ku Y Tags: Kobe J Med Sci Source Type: research

Non-detection of Epstein-Barr virus and human papillomavirus in a region of high gastric cancer risk indicates a lack of a role for these viruses in gastric carcinomas
Gastric mucosa tissue was collected from patients with gastroduodenal diseases in a region of norrteastern China showing a high risk of gastric cancer incidence. The presence of EBV and HPV were assayed to investigate the relationship between gastric carcinomas and virus infection. Neither EBV nor HPV DNA was detected in tissue from the patients. The role of EBV and HPV in gastric cancer is not well understood and still needs to be clarified. (Source: Genetics and Molecular Biology)
Source: Genetics and Molecular Biology - June 17, 2013 Category: Genetics & Stem Cells Source Type: research

Bioinformatics analysis of the gene expression profile in Bladder carcinoma
Bladder carcinoma, which has the ninth highest incidence among malignant tumors in the world, is a complex, multifactorial disease. The malignant transformation of bladder cells results from DNA mutations and alterations in gene expression levels. In this work, we used a bioinformatics approach to investigate the molecular mechanisms of bladder carcinoma. Biochips downloaded from the Gene Expression Omnibus (GEO) were used to analyze the gene expression profile in urinary bladder cells from individuals with carcinoma. The gene expression profile of normal genomes was used as a control. The analysis of gene expression revea...
Source: Genetics and Molecular Biology - June 17, 2013 Category: Genetics & Stem Cells Source Type: research

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells
Conclusions: Our results have indicated the treatment of cells involving use of the siRNA targeting efflux pumps could be a beneficial approach in the future. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - June 17, 2013 Category: Veterinary Research Authors: Karol Paw¿owskiJoanna MuchaKinga MajchrzakTomasz MotylMagdalena Król Source Type: research

Comparison of radiographic and pathologic sizes of renal tumors
Conclusions Renal tumor size was overestimated by radiography as compared with pathology. The difference was just 0.22 cm with little clinical significance, suggesting that CT provides an accurate method to estimate renal tumor size preoperatively. (Source: International Braz J Urol)
Source: International Braz J Urol - June 16, 2013 Category: Urology & Nephrology Source Type: research

Urine screening by Seldi-Tof, followed by biomarker identification, in a Brazilian cohort of patients with Renal Cell Carcinoma (RCC)
Conclusions The down expression of Protein K-12 and MASP-2 make them good candidates for RCC urine marker and should be validated in a bigger cohort including the other less common histological RCC subtypes. (Source: International Braz J Urol)
Source: International Braz J Urol - June 16, 2013 Category: Urology & Nephrology Source Type: research

Visualization of the leakage of pancreatic juice using a chymotrypsin‐activated fluorescent probe
ConclusionThe chymotrypsin probe enabled determination of the protease activity in drained pancreatic fluid samples and allowed real‐time visualization of pancreatic juice leakage during surgery. (Source: British Journal of Surgery)
Source: British Journal of Surgery - June 16, 2013 Category: Surgery Authors: S. Yamashita, M. Sakabe, T. Ishizawa, K. Hasegawa, Y. Urano, N. Kokudo Tags: Original Article Source Type: research

[Percutaneous closure of patent ductus arteriosus: short term results].
Conclusion: Transcatheter closure of PDA with ADO-1 and ADO-2 devices has low morbidity and mortality with high rates of success in selected patients. PMID: 23760118 [PubMed - in process] (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - June 16, 2013 Category: Cardiology Authors: Kaya Y, Bulut MO, Yurtdaş M, Karakurt A, Güvenç TS, Söylemez N, Güler A, Gönüllü E, Ceylan Y, Akdemir R Tags: Turk Kardiyol Dern Ars Source Type: research

Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the southern Swedish lung cancer study.
Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung. PMID: 23765532 [PubMed - in process] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - June 16, 2013 Category: Cancer & Oncology Authors: Brunnström H, Johansson L, Jirström K, Jönsson M, Jönsson P, Planck M Tags: Am J Clin Pathol Source Type: research

Hereditary Syndromes With Associated Renal Neoplasia: A Practical Guide to Histologic Recognition in Renal Tumor Resection Specimens
Many hereditary tumor syndromes are associated with neoplasms of the kidney. It is becoming increasingly well recognized that a given familial tumor syndrome may be very heterogenous in clinical appearance and that unrecognized patients may present initially for the treatment of a renal mass. It is therefore important for surgical pathologists to be aware of the specific gross and microscopic findings in the kidney that suggest a possible syndromic association. In this review, we detail the histologic features of syndromic-associated renal neoplasms, describe the presence of characteristic changes in the background renal p...
Source: Advances in Anatomic Pathology - June 16, 2013 Category: Pathology Tags: Review Articles Source Type: research

Aggressive Liver Cancer Tracked to Genetic Driver (CME/CE)
(MedPage Today) -- An oncofetal gene normally silenced in the adult liver contributes to hepatocellular carcinoma through several cellular pathways, investigators reported. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 15, 2013 Category: Gastroenterology Source Type: news

Successful single-cycle rituximab treatment in a patient with pemphigus vulgaris and squamous cell carcinoma of the tongue and IgG antibodies to desmocollins
To the Editor: Pemphigus can be triggered by many insults, including drugs, infections, and neoplasms. Radiation-induced pemphigus vulgaris accompanied by an internal malignancy has been rarely reported, but the link between pemphigus vulgaris and malignancy still needs to be elucidated. Moreover, the treatment of pemphigus in this condition is often challenging, as the patient’s immune system is already suppressed by radiation and chemotherapy. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 15, 2013 Category: Dermatology Authors: Jaehwan Kim, Kwesi Teye, Hiroshi Koga, Sue-Ching Yeoh, Denis Wakefield, Takashi Hashimoto, Dedee F. Murrell Tags: JAAD Online Source Type: research

Emergence of a squamous cell carcinoma phenotype following treatment of metastatic basal cell carcinoma with vismodegib
To the Editor: Vismodegib is a small molecule inhibitor of the hedgehog signaling pathway approved by the US Food and Drug Administration (FDA) for the treatment of basal cell carcinoma (BCC) as of January 2012, and phase I clinical trial results were recently published. Given the potential for its widespread use, possible unexpected outcomes are pertinent to dermatologists and oncologists. A case of squamous cell carcinoma (SCC) emerging after treatment of metastatic BCC with vismodegib is described. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 15, 2013 Category: Dermatology Authors: Amy Iarrobino, Jane L. Messina, Ragini Kudchadkar, Vernon K. Sondak Tags: JAAD Online Source Type: research

Periocular actinic keratosis, keratinocyte carcinomas, and eyeglasses use
This study sought to determine the role of eyeglasses use on prevention of periocular KCs and actinic keratoses (AKs). (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - June 15, 2013 Category: Dermatology Authors: Kachiu C. Lee, Martin A. Weinstock, Department of Veterans Affairs Topical Tretinoin Chemoprevention Trial Group Tags: Research Letters Source Type: research

Is living donor liver transplantation really equivalent to deceased donor liver transplantation?
Living donor liver transplantation (LDLT) has developed as an alternative to deceased donor liver transplantation (DDLT) in order to overcome the critical shortage of deceased organ donations. Particularly in regions with low deceased donation rates, like Asian, LDLT for end stage liver disease significantly reduces the risk of death or drop‐off the wait list without compromising posttransplant survival. A preference for LDLT to DDLT may depend on the original disease representing the indication for liver transplantation (LT). LDLT offers a timely alternative to DDLT for patients with hepatocellular carcinoma (HCC). (Sou...
Source: Transplant International - June 15, 2013 Category: Transplant Surgery Authors: Hideki Ohdan Tags: Original Article Source Type: research

High HMGA2 expression and high body mass index negatively affect the prognosis of patients with ovarian cancer
Abstract HMGA2 is a small, non‐histone, chromatin‐associated protein with a key role in tumorigenesis and adipogenesis. Indeed, HMGA2 overexpression has been frequently detected in several malignant neoplasms and inhibition of its expression prevents thyroid cell transformation. Moreover, HMGA2 null mice show a pigmy phenotype with a great reduction in fat tissue. To investigate whether HMGA2 expression correlates with clinico‐pathological parameters and patient outcome, immunohistochemical analysis of HMGA2 expression was performed in ovarian cancer specimens from 117 patients.HMGA2 overexpression was found in 39% o...
Source: Journal of Cellular Physiology - June 14, 2013 Category: Cytology Authors: Daniela Califano, Sandro Pignata, Nunzia Simona Losito, Alessandro Ottaiano, Stefano Greggi, Veronica De Simone, Sabrina Cecere, Concetta Aiello, Francesco Esposito, Alfredo Fusco, Gennaro Chiappetta Tags: Original Research Article Source Type: research

Current Perspectives in Bladder Cancer ManagementCurrent Perspectives in Bladder Cancer Management
This overview focuses on current best-evidence in the diagnosis and management of transitional cell carcinoma, which comprises over 90% of bladder cancers. International Journal of Clinical Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 14, 2013 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

A Human Thyroid Cancer Cell Line, DH-14-3, Newly Established from Poorly Differentiated Thyroid Carcinoma.
Abstract Poorly differentiated thyroid carcinoma (PDTC) is a newly recognized histological type of malignant thyroid tumor, accounting for about 2 - 13% of all thyroid carcinomas. PDTC is considered as a morphologically and biologically intermediate stage between well-differentiated thyroid carcinoma and anaplastic thyroid carcinoma. PDTC preferentially manifests bone metastases. We here established a cell line from a resected tumor specimen from a 70-year-old male patient with PDTC who presented with multiple bone metastases. This new thyroid tumor cell line was designated as DH-14-3 and was subsequently grown in ...
Source: The Tohoku Journal of Experimental Medicine - June 14, 2013 Category: Research Authors: Teshima J, Doi H, Fujimori K, Watanabe M, Nakajima N, Nakano T, Takahashi Y, Ohuchi N, Satomi S Tags: Tohoku J Exp Med Source Type: research

Morphology of the patent ductus arteriosus does not preclude successful patent ductus arteriosus stent implantation in high‐risk patients undergoing hybrid stage I palliation: Recommendations to optimize ductal stent positioning
ConclusionsMid‐ to long‐term follow‐up indicates that PDA stents remain widely patent regardless of ductal morphology until comprehensive stage II repair. © 2013 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - June 14, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Michael R. Recto, Sandy Doyle, Vitor C. Guerra, Song Gui Yang, Thomas Yeh Tags: Pediatric and Congenital Heart Disease Source Type: research

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Conclusions: Our results suggest that Wee1 may be involved in the progression of vulvar carcinomas. Based on our in vitro results, Wee1 is unlikely to function as a target for mono-treatment of these patients. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Gry MagnussenEllen HellesyltJahn NeslandClaes TropeVivi FlørenesRuth Holm Source Type: research

Isolated Cranial Mononeuropathy: An Unusual Initial Presentation and Disease Progression of Metastatic Carcinoma of the Breast [DIAGNOSIS IN ONCOLOGY]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - June 14, 2013 Category: Cancer & Oncology Authors: Lim, Chandramouleeswaran, Zagar, Budwit, Anders Tags: Diagnosis & Staging, MRI DIAGNOSIS IN ONCOLOGY Source Type: research

Biochemical and biological characterization of exosomes containing prominin-1/CD133
Exosomes can be viewed as complex "messages" packaged to survive trips to other cells in the local microenvironment and, through body fluids, to distant sites. A large body of evidence indicates a pro-metastatic role for certain types of cancer exosomes. We previously reported that prominin-1 had a pro-metastatic role in melanoma cells and that microvesicles released from metastatic melanoma cells expressed high levels of prominin-1. With the goal to explore the mechanisms that govern proteo-lipidic-microRNA sorting in cancer exosomes and their potential contribution(s) to the metastatic phenotype, we here employed promini...
Source: Molecular Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Germana RappaJavier MercapideFabio AnzanelloRobert PopeAurelio Lorico Source Type: research

Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women
Background: Pure mucinous carcinoma (MC) is found in about 3.5% of all newly diagnosed breast cancer patients in Taiwan. MC is a relatively rare malignancy of breast cancer, and its nature, behaviors, treatment pattern and long-term follow-up are not well understood. The study aimed to investigate the incidence rate, treatment patterns, and prognostic factors of MC of the breast and the clinical long-term outcomes compared with infiltrating ductal carcinoma not otherwise specified (IDC) in the middle and south Taiwanese women. Methods: Data from 93 patients with breast MC were retrospectively reviewed and the clinicopathol...
Source: World Journal of Surgical Oncology - June 14, 2013 Category: Cancer & Oncology Authors: Hsin-Shun TsengChe LinSzu-Erh ChanSu-Yu ChienShou-Jen KuoShou-Tung ChenTsai-Wang ChangDar-Ren Chen Source Type: research

Atypical Lobular Hyperplasia Of the Breast
Atypical lobular hyperplasia is not breast cancer. If you have been diagnosed with atypical lobular hyperplasia, then you need to know how it affects your risk for breast cancer, and how to get a clear diagnosis and treatment options. Learn more about atypical lobular hyperplasia here. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - June 14, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

Invasive Lobular Carcinoma – ILC Breast...
Invasive Lobular Carcinoma (ILC) is a type of breast cancer that starts in the lobules of your breast, where milk is produced. Invasive Lobular Carcinoma does not always feel like a breast lump, because it may grow in a web-like mass. Learn about the symptoms, diagnosis and treatment for Invasive Lobular Carcinoma. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - June 14, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

Tubular Carcinoma of the Breast
Tubular carcinoma is a rare type of invasive ductal carcinoma of the breast. Tubular carcinomas tend to be small, estrogen-receptor positive, HER2/neu negative. Your chance of recovery and survival after treatment for a tubular carcinoma is very good. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - June 14, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

2,3-cis-2R,3R-()-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell line
Conclusion: This study is the first to characterize the novel flavan-3-ol compound, rhodoeosein, and its ability to induce estrogenic activity in human cell lines. Rhodoeosein and emodin may have potential therapeutic applications as natural products activating ERbeta, and further characterization of rhodoeosein is necessary to evaluate its selectivity as a cell type-specific ER agonist. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - June 14, 2013 Category: Complementary Medicine Authors: Jennifer BrennanMichael DenisonDirk HolstegeProkopios MagiatisJerry DallasElisa GutierrezAnatoly SoshilovJames Millam Source Type: research

Gross examination by the surgeon as an alternative to frozen section for assessment of adequacy of surgical margin in head and neck squamous cell carcinoma
ConclusionAchievement of 7 mm surgical margin measured by a surgeon obviates the need for frozen section. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Pankaj Chaturvedi, Sourav Datta, Sudhir Nair, Deepa Nair, Prashant Pawar, Sagar Vaishampayan, Asawari Patil, Shubhada Kane Tags: Original Article Source Type: research

Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta‐analysis of English‐language literature
ConclusionTLM is oncologically sound in the salvage setting with high larynx‐preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Yujay Ramakrishnan, Mike Drinnan, Foon Ng Kee Kwong, David G. Grant, Hisham Mehanna, Terry Jones, Vinidh Paleri Tags: Clinical Review Source Type: research

Salivary duct carcinoma responding to trastuzumab‐based therapy: Case report and review of the literature
ConclusionTrastuzumab‐based therapy is a potential therapeutic option for patients with SDC. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Jairam Krishnamurthy, Devi Mukkai Krishnamurty, John J. Baker, Weining Zhen, Daniel Lydiatt, Apar Kishor Ganti Tags: Case Report Source Type: research

Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population‐level analysis of 2400 patients
ConclusionGrade influences the prognosis and distribution of nodal metastases. Results indicate that management guidelines should vary based on grade. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Michelle M. Chen, Sanziana A. Roman, Julie A. Sosa, MA,Benjamin L. Judson Tags: Original Article Source Type: research

Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma
ConclusionAnalysis of the largest laryngeal BSCC series to date (n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Valerie A. Fritsch, Eric J. Lentsch Tags: Original Article Source Type: research

Incurable recurrences in patients with oropharyngeal and hypopharyngeal carcinomas
ConclusionThe knowledge about the courses of disease and especially the remaining lifetime after diagnosed incurability could facilitate the planning of the remaining lifetime in order to achieve the best possible quality of life. © 2013 Wiley Periodicals, Inc. Head Neck, 2013 (Source: Head and Neck)
Source: Head and Neck - June 14, 2013 Category: ENT & OMF Authors: Susanne Wiegand, Annette P. Zimmermann, Hans‐Helge Müller, Jochen A. Werner, Andreas M. Sesterhenn Tags: Original Article Source Type: research

Esophageal leukoplakia or epidermoid metaplasia: a clinicopathological study of 18 patients
; Elizabeth A Montgomery (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Aatur D SinghiChristina A ArnoldClinton D CrowderDora M Lam-HimlinLysandra VoltaggioElizabeth A Montgomery Tags: epidermoid metaplasia esophagus leukoplakia orthokeratotic dysplasia squamous cell carcinoma squamous dysplasia Source Type: research

Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles
e Gilks & David G Huntsman (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Melissa K McConechyJiarui DingJanine SenzWinnie YangNataliya MelnykAlicia A ToneLeah M PrenticeKimberly C WiegandJessica N McAlpineSohrab P ShahCheng-Han LeePaul J GoodfellowC Blake GilksDavid G Huntsman Tags: carcinoma CTNNB1 endometrial endometrioid mutations ovarian PTEN Source Type: research

Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice
& Pei Hui (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Natalia BuzaDiana P EnglishAlessandro D SantinPei Hui Tags: endometrial serous carcinoma fluorescent in situ hybridization HER2 testing heterogeneity immunohistochemistry Source Type: research

Phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia
amp; James G Rheinwald (Source: Modern Pathology AOP)
Source: Modern Pathology AOP - June 14, 2013 Category: Pathology Authors: Alvaro P PintoMartin DegenPatricia BarronChristopher P CrumJames G Rheinwald Tags: laminin lichen sclerosus S6 squamous cell carcinoma VIN Source Type: research

The Paracrine Effect of Cancer‐associated Fibroblast‐induced Interleukin‐33 Regulates the Invasiveness of Head and Neck Squamous Cell Carcinoma
Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer‐related death worldwide. The prognosis of HNSCC is usually poor because of its propensity for extensive invasion, local recurrence and frequent regional lymph node metastasis even at initial diagnosis. Carcinoma‐associated fibroblasts (CAFs), a major type of tumour‐surrounding stromal cell, generate mediators through which they interact with tumours and contribute to cancer progression. The orchestration between CAFs and cancer cells is complex. Despite recent studies demonstrating the paracrine effect of stromal cells in th...
Source: The Journal of Pathology - June 14, 2013 Category: Pathology Authors: Su‐Feng Chen, Shin Nieh, Shu‐Wen Jao, Min‐Zu Wu, Chia‐Lin Liu, Yun‐Ching Chang, Yaoh‐Shiang Lin Tags: Original Article Source Type: research

Hyper‐expression of PAX2 in human metastatic prostate tumors and its role as a cancer promoter in an in vitro invasion model
CONCLUSIONSOur data suggested that PAX2 hyper‐expression promotes the development of the metastatic state in prostate cancer cells, presumably through upregulating the expression of cell membrane proteins. Prostate 9999: 1–10, 2013. © 2013 Wiley Periodicals, Inc. (Source: The Prostate)
Source: The Prostate - June 14, 2013 Category: Urology & Nephrology Authors: Takashi Ueda, Saya Ito, Takumi Shiraishi, Prakash Kulkarni, Akihisa Ueno, Hideo Nakagawa, Yasunori Kimura, Fumiya Hongo, Kazumi Kamoi, Akihiro Kawauchi, Tsuneharu Miki Tags: Original Article Source Type: research

Hepatocyte nuclear factor‐4α reverses malignancy of hepatocellular carcinoma through regulating miR‐134 in the DLK1‐DIO3 region
Conclusion: Our data highlight the importance of the miR‐379‐656 cluster in the inhibitory effect of HNF4α on HCC, and suggest that regulation of the HNF4α‐miRNA cascade may have beneficial effects in the treatment of HCC. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - June 14, 2013 Category: Internal Medicine Authors: Chuan Yin, Pei‐Qin Wang, Wen‐Ping Xu, Yuan Yang, Qing Zhang, Bei‐Fang Ning, Ping‐Ping Zhang, Wei‐Ping Zhou, Wei‐Fen Xie, Wan‐Sheng Chen, Xin Zhang Tags: Hepatobiliary Malignancies Source Type: research

Population‐based epidemiology, malignancy risk and outcome of primary sclerosing cholangitis
Conclusion: This study exemplifies that for relatively rare diseases it is paramount to collect observational data from large population‐based cohorts, because incidence and prevalence rates of PSC are markedly lower and survival much longer than previously reported. The selection bias‐free population‐based cohort showed a significantly longer survival compared to the tertiary referral cohort. CRC can develop at an early age, warranting surveillance from time of PSC diagnosis. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - June 14, 2013 Category: Internal Medicine Authors: Kirsten Boonstra, Rinse K. Weersma, Karel J. van Erpecum, Erik A. Rauws, B.W. Marcel Spanier, Alexander C. Poen, Karin M. van Nieuwkerk, Joost P. Drenth, Ben J. Witteman, Hans A. Tuynman, Anton H. Naber, Paul J. Kingma, Henk R. van Buuren, Bart van Hoek, Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Paracrine signals from liver sinusoidal endothelium regulate hepatitis C virus replication
Conclusion: These studies identify a role for LSEC and BMP4 in HCV infection and highlight BMP4 as a new therapeutic target for treating individuals with liver disease. (HEPATOLOGY 2013.) (Source: Hepatology)
Source: Hepatology - June 14, 2013 Category: Internal Medicine Authors: Ian A Rowe, Sukhdeep K Galsinh, Garrick K Wilson, Richard Parker, Sarah Durant, Catalin Lazar, Norica Branza‐Nichita, Roy Bicknell, David H Adams, Peter Balfe, Jane A McKeating Tags: Viral Hepatitis Source Type: research

Polymorphisms of the core, NS3, and NS5A proteins of hepatitis C virus genotype 1b associate with development of hepatocellular carcinoma
Conclusion: HCV isolates with core‐Gln70 and/or NS3‐Tyr1082/Gln1112 are more closely associated with HCC development compared to those with non‐(Gln70 plus NS3‐Tyr1082/Gln1112). (HEPATOLOGY 2013) (Source: Hepatology)
Source: Hepatology - June 14, 2013 Category: Internal Medicine Authors: Ahmed El‐Shamy, Michiko Shindo, Ikuo Shoji, Lin Deng, Tadao Okuno, Hak Hotta Tags: Viral Hepatitis Source Type: research