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Migraine

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TCT: PFO No Panacea for Migraine
WASHINGTON (MedPage Today) -- Percutaneous patent foramen ovale (PFO) closure did not significantly reduce the number of monthly migraine days compared with medical treatment, researchers reported here. (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - September 17, 2014 Category: Cardiology Source Type: news

PFO Closure Fails Anew in Migraine: PRIMAPFO Closure Fails Anew in Migraine: PRIMA
PRIMA set out to assess reduction in migraine among people with migraine with aura after PFO closure and in fact did see benefit for this outcome. The problem? That wasn't the trial's primary end point. Heartwire (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - September 16, 2014 Category: Cardiology Tags: Cardiology News Source Type: news

Rhabdomyolysis associated with dengue fever in a lupic patient
This report describes the case of a woman with systemic lupus erythematous (SLE) that developed rhabdomyolysis after being infected by dengue virus. There are only a few cases of SLE accompanied by rhabdomyolysis, none of them associated with dengue fever. Initially, the woman presented high fever, myalgia, muscular weakness, mild headache, polyarthralgia and thrombocytopenia reminding a lupus flare, but since the number of people infected by dengue at that time was high and the symptoms from both conditions are similar, a dengue serology was requested. After a few days, the patient developed rhabdomyolysis. She was then s...
Source: Revista Brasileira de Reumatologia - September 16, 2014 Category: Rheumatology Source Type: research

[Corrections] Corrections
Furman JM, Marcus DA, Balaban CD. Vestibular migraine: clinical aspects and pathophysiology. Lancet Neurol 2013; 12: 706–15—In the epidemiology section, the reported prevalence of vestibular migraine in women aged 40–54 years should be 5% and not 1%. This correction has been made to the online version as of Sept 15. (Source: Lancet Neurology)
Source: Lancet Neurology - September 16, 2014 Category: Neurology Authors: The Lancet Neurology Tags: Corrections Source Type: research

Sex can give you a headache... so can standing up suddenly and even taking too many pain killers: How you can conquer that head splitting pain
Anyone who suffers from them knows, headaches can be extremely debilitating. Here we’ve enlisted the help of the country’s top experts to show you how to banish the pain. (Source: the Mail online | Health)
Source: the Mail online | Health - September 16, 2014 Category: Consumer Health News Source Type: news

TENSION HEADACHE RELIEF Capsule [AZ Pharmaceutical, Inc.]
Updated Date: Sep 16, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 16, 2014 Category: Drugs & Pharmacology Source Type: news

Could meditation help combat migraines?
ConclusionThis pilot RCT, based on just 19 adult migraine sufferers, showed an eight-week mindfulness-based stress reduction course led to benefits for headache duration, disability, self-efficacy and mindfulness measures, compared to a control group who received usual care. There were non-significant benefits observed for measures of migraine frequency and severity. Both groups continued to take any migraine medication (prophylactic or for treatment during a headache) they were already taking before the trial.The research group themselves were very reasonable in their conclusions and called for larger trials to be done t...
Source: NHS News Feed - September 15, 2014 Category: Consumer Health News Tags: Medical practice Neurology Mental health Source Type: news

A case of chronic hepatitis C patient of myocardial ischemia accompanied with interstitial pneumonia induced by pegylated interferon alpha-2a.
Abstract After 3 months of combination treatment using interferon α-2a and Ribavirin, a case of 59-year-old female patient with chronic viral hepatitis C demonstrated symptoms such as headache, dizziness accompanied by nausea, vomiting, dry cough, breathing difficulty, and shortness of breath. Dynamic electrocardiogram showed occasional atrial premature beats, paroxysmal tachycardia, and abnormal ST-T (T wave inversion and prolongation of the QT interval). Ambulatory blood pressure indicated that mean blood pressure was elevated than before. Myocardial radionuclide scan showed focal myocardial ischemia in left ven...
Source: International Journal of Clinical and Experimental Pathology - September 15, 2014 Category: Pathology Authors: Qu C, Zheng Z, Liu W, Jiao J, Zhu J Tags: Int J Clin Exp Pathol Source Type: research

Failure to fill a first prescription of a new medication is common in primary care settings
Commentary on: Tamblyn R, Eguale T, Huang A, et al.. The incidence and determinants of primary non-adherence with prescribed medication in primary care: a cohort study. Ann Intern Med 2014;160:441–50. Context Poor medication adherence is common and has been a long-standing concern of providers, payers and policy-makers alike. The incidence and prevalence of primary non-adherence, or the failure to fill a first prescription of a new medication, is increasingly quantifiable with advances in health information technology. Prior work suggests that as many as one-third of new prescriptions may not be filled, although rate...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Hwang, C. S., Alexander, G. C. Tags: EBM Quality improvement, Health informatics, Epidemiologic studies, General practice / family medicine, Urinary tract infections, Headache (including migraine), Pain (neurology), Ischaemic heart disease, Vulvovaginal disorders, Urinary tract infections Source Type: research

Daily meditation could help 8m conquer pain of migraines
DAILY meditation may be the most effective way of tackling migraine. (Source: Daily Express - Health)
Source: Daily Express - Health - September 13, 2014 Category: Consumer Health News Source Type: news

Daily medication could help 8m conquer pain of migraines
DAILY meditation may be the most effective way of tackling migraine. (Source: Daily Express - Health)
Source: Daily Express - Health - September 12, 2014 Category: Consumer Health News Source Type: news

Fractyl raises $40 million in support of ablation-based approach to type 2 diabetes | Medtech funding for the week of September 8, 2014
Here's a look at some of the top legal news stories for medical device companies this week: Fractyl raises $40M, touts positive early results for ablation-based diabetes therapy; eNeura raises $5.8M for home migraine device; Integrity Applications lands $3M for non-invasive glucose sensor; Tryton Medical raises $20M for side-branch stent trial; Smart inhaler maker raises $14.5M Diabetes: Fractyl raises $40M, touts positive early results for ablation-based diabetes therapy September 5, 2014 by Arezu Sarvestani eNeura Therapeutics, Fractyl, Integrity Applications, Propeller Health, Tryton Medical Inc.News Well, F...
Source: Mass Device - September 12, 2014 Category: Medical Equipment Authors: MassDevice Source Type: news

Comprehensive management of patients presenting to the otolaryngologist for Sinus pressure, pain, or headache
ConclusionsWe present the first series detailing management of patients with sinus‐headache pain in an otolaryngology practice. Such symptoms have multifactorial etiologies. Positive sinus CT results require cautious interpretation. ESS should be judiciously used. Interdisciplinary care is critical for success: approximately 50% of patients benefited from otolaryngic management, 50% needed neurological treatment, and 7% required dental disease management. Level of Evidence4 Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - September 12, 2014 Category: ENT & OMF Authors: Devyani Lal, Alexis Rounds, David W. Dodick Tags: Allergy/Rhinology Source Type: research

Benign paroxysmal vertigo of childhood is a precursor of migraine
Conclusions BPVC is characterised by short and sudden attacks of vertigo and imbalance, with no aura and with nystagmus. Due to its short duration and since children often close their eyes, nystagmus is difficult to establish. Imbalance may persist for few... (Source: Archives of Disease in Childhood - Education and Practice)
Source: Archives of Disease in Childhood - Education and Practice - September 12, 2014 Category: Pediatrics Authors: Prasad, M. Tags: Journalology, Epidemiologic studies, Drugs: CNS (not psychiatric), Headache (including migraine), Child health, Ear, nose and throat/otolaryngology, Competing interests (ethics) What I ' ve learnt from European Journal of Paediatric Neurology Source Type: research

Study: Meditation offers migraine relief
Brooks HaysWINSTON-SALEM, N.C., Sept. 11 (UPI) -- A new study suggests meditation and yogic breathing can help mitigate migraine pain -- specifically a routine called mindfulness-based stress reduction. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 11, 2014 Category: Consumer Health News Source Type: news

Meditation may mitigate migraine misery
Meditation might be a path to migraine relief, according to a new study. "For the approximate 36 million Americans who suffer from migraines, there is big need for non-pharmaceutical treatment strategies, and doctors and patients should know that meditation is a safe intervention that could potentially decrease the impact of migraines," one author said. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 11, 2014 Category: Science Source Type: news

Stroke and Migraine Headaches in Females
A stroke happens when part of a person's brain is deprived of its blood supply. There are two main types of stroke, one of which is suggested to have a link with certain types of migraine headaches. Migraine affects three times as many women as men, yet the incidence of stroke is twice as high in men as it is in women. (Source: Disabled World)
Source: Disabled World - September 11, 2014 Category: Disability Tags: Female Health Source Type: news

Meditation may mitigate migraine misery
(Wake Forest Baptist Medical Center) Meditation might be a path to migraine relief, according to a new study by researchers at Wake Forest Baptist Medical Center. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2014 Category: Global & Universal Source Type: news

Initial serum ferritin predicts number of therapeutic phlebotomies to iron depletion in secondary iron overload.
CONCLUSIONS: Initial SF but not transfusion burden predicted number of phlebotomies to target in patients with TIO. Despite good treatment tolerance, significant losses to follow-up were noted. Providing patients with an estimated phlebotomy number and follow-up duration, and thus a finite endpoint, may improve compliance. Hepatic function improved with iron offloading. PMID: 25209879 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 11, 2014 Category: Hematology Authors: Panch SR, Yau YY, West K, Diggs K, Sweigart T, Leitman SF Tags: Transfusion Source Type: research

Aggressive pituitary lesion with a remarkably high Ki-67
The uncommon aggressive pituitary tumors are named carcinomas when metastases are detected, either in the central nervous system and/or systemically. Some cases are associated with hormonal overproduction, but most are diagnosed because of local symptoms. These neoplasias are generally refractory to current treatments. A 51 year-old woman presented sudden onset of headache, left arm paresis and left facial hypoesthesia. Computed tomography scan and magnetic resonance imaging revealed a pituitary tumor invading the left sphenoidal and cavernous sinuses. Laboratory data excluded hormonal hypersecretion. The patient underwent...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research

Persistence of intrasellar trigeminal artery and simultaneous pituitary adenoma: description of two cases and their importance for the differential diagnosis of sellar lesions
Persistent trigeminal artery (PTA) is the most frequent embryonic communication between the carotid and vertebrobasilar systems. However, hormonal changes or the association of PTA with other sellar lesions, such as pituitary adenomas, are extremely rare. The aim of the present study was to report two patients with intrasellar PTA and simultaneous pituitary adenoma in order to emphasize the importance of differential diagnoses for sellar lesions. Case 1. A female patient, 41 years old, was admitted with a history of chronic headache (> 20 years). Pituitary magnetic resonance imaging (MRI) showed a rounded lesion in the ...
Source: Arquivos Brasileiros de Endocrinologia e Metabologia - September 10, 2014 Category: Endocrinology Source Type: research

CAM for Migraine and Cluster Headaches
Alternative and Complementary Approaches to Migraine and Cluster Headaches (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - September 9, 2014 Category: Journals (General) Source Type: news

A randomised, multicentre, double blind, placebo controlled trial to evaluate the efficacy and safety of cilostazol in patients with vasospastic angina
Conclusions Cilostazol is an effective therapy for patients with VSA uncontrolled by conventional amlodipine therapy, and has no serious side effects. Trial registration number NCT01444885. (Source: Heart)
Source: Heart - September 9, 2014 Category: Cardiology Authors: Shin, E.-S., Lee, J.-H., Yoo, S.-Y., Park, Y., Hong, Y. J., Kim, M. H., Lee, J.-Y., Nam, C.-W., Tahk, S.-J., Kim, J.-S., Jeong, Y.-H., Lee, C. W., Shin, H. K., Kim, J.-H. Tags: Coronary artery disease Source Type: research

Large-Volume Blood Patch to Multiple Sites in the Epidural Space through a Single-Catheter Access Site for Treatment of Spontaneous Intracranial Hypotension [SPINE]
CONCLUSIONS: Our experience supports the use of a large-volume blood patch to multiple sites in the epidural space through a single-catheter access site for the treatment of spontaneous intracranial hypotension. Additionally, our results indicate a role for this procedure in refractory cases of spontaneous intracranial hypotension. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - September 9, 2014 Category: Radiology Authors: Griauzde, J., Gemmete, J. J., Chaudhary, N., Wilson, T. J., Pandey, A. S. Tags: SPINE Source Type: research

Thunderclap headache: are we investigating sufficiently?
Conclusions Emergency department doctors appear to employ an appropriately low threshold for neuroimaging in TCH, however there is little evidence that LPs are sufficiently performed where imaging is negative, or that further investigation is arranged following negative LP. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Graham, N. Tags: Abstracts Source Type: research

White matter lesions after cerebral aneurysm coiling
In this study we investigated WMLs in patients with cerebral aneurysms. Consecutive patients were identified who underwent endovascular coiling of cerebral aneurysms at the Royal Preston Hospital between 2008 and 2010, for whom follow-up MRI scans were available. Scans from patients showing WMLs were anonymised and the lesion burden was estimated using the Fazekas visual rating score and by software-aided volumetric analysis. Comparison was made with an age-stratified outpatient control group who underwent brain MRI for headache. 157 patients had follow-up MRI scans. WMLs were reported in 38.2%, and 48% were scored Fazekas...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Anandarajah, M., Spassova, S., Brown, S., Wuppalapati, S., Vidyasagar, R., Emsley, H. Tags: Abstracts Source Type: research

Thunderclap headache: are we investigating sufficiently?
Conclusions Emergency department doctors appear to employ an appropriately low threshold for neuroimaging in TCH, however there is little evidence that LPs are sufficiently performed where imaging is negative, or that further investigation is arranged following negative LP. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: N, G. Tags: Abstracts Source Type: research

The clinical and genetic spectrum of hemiplegic migraine
Conclusions CACNA1A is a major disease gene but HM shows significant clinical and, genetic heterogeneity. The paroxysmal disorders gene panel will be an important diagnostic tool in investigating HM, related disorders and the role of ion channels. Whole-exome sequencing is underway for unresolved cases. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Jaffer, F., Gardiner, A., Polke, J., Pittman, A., Prabhakar, P., Kurian, M., Sweeney, M., Hanna, M. G., Houlden, H. Tags: Abstracts Source Type: research

Activating mutations in stim1 and orai1 cause overlapping syndromes of tubular aggregate myopathy and congenital miosis
We describe the clinical phenotype in five members of an English family (three female), with tubular aggregate myopathy and congenital miosis who were previously described at this meeting 10 years ago (Nicholl DJ et al JNNP 2004;75:1213)and are genealogically linked to other UK families (Shahrizaila et al 2004 Familial myopathy with tubular aggregates associated with abnormal pupils. Neurology 63:1111–13). The phenotype is similar to the previously described Stormorken syndrome (MIM 185070) but without associated thrombocytopathy, asplenia, dyslexia, icthyosis, or migraine. Patients, ranging in age from 22 years to 7...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Nicholl, D., Sadalage, G., Shahrizaila, N., Wills, A., Rose, M., Bremner, F., Wierenga, K. Tags: Abstracts Source Type: research

See no evil, hear no evil, speak no evil... keep it a sicret
A 21-year-old presented with a one-month history of confusion and headache, with collateral history suggestive of focal seizures. Examination revealed an encephalopathic patient with a bilateral internuclear ophthalmoplegia and a spastic ataxic quadraparesis. MRI demonstrated multiple non-enhancing hyperintense T2 lesions in the cerebellum, corpus callosum, grey and white matter, some with restricted diffusion. There was marked posterior fossa leptomeningeal enhancement. CSF protein was 2.32g, with 5 lymphocytes and negative oligoclonal bands. Brain biopsy showed non-specific inflammatory changes. Extensive infective, infl...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Dobson, R., Doshi, A., Massey, L., Crowe, L., Wood, R., Vundavalli, S., Hughes, E., Lunn, M., Plant, G., Wickremaratchi, M. Tags: Abstracts Source Type: research

Thunderclap headache--not a rash diagnosis
A 62-year-old lady presented with thunderclap onset, severe, bi-occipital headache with associated motion sensitivity and vomiting on a background of gradually worsening, constant bi-temporal throbbing pain over a two year period. CT brain demonstrated acute superior frontocortical subarachnoid blood but CT venogram, angiogram and brain MRI were all normal. Peripheral autoimmune and inflammatory serology was unremarkable, as were initial results from CSF analysis. Cerebral vasculitis was suspected and the patient underwent formal catheter angiography. This found multifocal irregularity of the intracranial medium and small ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Barritt, A. W., Vundavalli, S., Hughes, P. Tags: Abstracts Source Type: research

Headache determines quality of life in iih
Conclusion We demonstrate a significant improvement in QOL in IIH following therapeutic weight loss and reduction in ICP. Improvement in headache was associated with enhanced QOL. We suggest that effective headache treatment will improve QOL in patients with IIH. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Mulla, Y., Markey, K., Patel, S., Sinclair, A. Tags: Abstracts Source Type: research

Long-term safety and efficacy of zonisamide versus carbamazepine monotherapy for treatment of partial seizures in adults with newly diagnosed epilepsy: results of a phase iii, multinational, randomised, double-blind, active-controlled study
Conclusion Zonisamide monotherapy demonstrated favourable long-term safety and maintenance of efficacy when used to treat partial seizures in adults with newly diagnosed epilepsy. No new or unexpected safety findings emerged. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Baulac, M., Bagul, M., Patten, A., Giorgi, L. Tags: Abstracts Source Type: research

Auto-regulation icp in iih due to chronic csf leak
We describe a patient that presented with symptoms and signs of raised intracranial pressure but also seizures and persistent CSF rhinorrhea when supine. Investigations revealed raised ICP with no structural cause and a cribriform plate defect with a large encephalocele. The defect appeared to auto-regulate intracranial pressure allowing the patient to maintain long symptom free periods but also led to the atypical presenting features. Patients rarely present with spontaneous CSF leaks but there is increasing recognition that CSF leakage from skull base defects may be a relatively common consequence of IIH. This can help t...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Osborne, C., Noyce, A., Sylvester, R. Tags: Abstracts Source Type: research

Long-term safety of perampanel: additional 10 months of data from extension study 307 in patients with partial-onset seizures aged 12 and above
Conclusions No new safety signals identified, with 7260 additional patient-months. Acknowledgements This study was sponsored by Eisai Inc. Medical writing support in developing the abstract was provided by Lisa Henry, of Choice Healthcare Solutions, and funded by Eisai Ltd. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Clement, J.-F., Krauss, G., Pillay, N., McLachlan, R., Hwang, P., Bagul, M., Zhu, J., Gee, M. Tags: Abstracts Source Type: research

External trigeminal nerve stimulation (etns) for epilepsy
We offer patients with drug resistant epilepsy (aged 9+) eTNS and audit outcome. A self-adhesive electrode is placed on the forehead stimulating both trigeminal nerves (120 Hz, 30 seconds on/off). Patients set the current (noticeable/comfortable, <10mA, aiming >8 hours overnight). Results mean±SD, comparisons: paired ttest. Seven children started eTNS but two discontinued early (headache). Another developed transient hypopigmentation from the adhesive. Outcome for other 5 awaited. Sixteen adult started eTNS before October 2013. Two discontinued early (disliked sensation/unhappy with seizure pattern) and o...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Slaght, S., Said, M., Hughes, E., Ramdas, S., Richardson, M., Elwes, R., Nashef, L. Tags: Abstracts Source Type: research

Posterior reversible encephalopathy syndrome in puerperium
Discussion This case describes PRES secondary to eclampsia seven days postpartum, when typically, eclampsia in the postpartum period occurs within the first 48 hours. Prompt management of PRES often results in a good prognosis and brain lesions in PRES are often reversible. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Lim, S. H., Zoumprouli, A. Tags: Abstracts Source Type: research

Laughing 'til it hurts: a curious case of mirth and migraine
We report the case of a 46 year old woman referred to our Headache Clinic with a 12 month history of severe episodic headache. The headache was left-sided, pressure-like and reliably triggered by outbursts of laughter. Episodes lasted most of the day and were associated with kaleidoscopic visual disturbances, photophobia and nausea. The headache was not triggered by coughing, sneezing, bending forward or neck movement, and could be prevented if she avoided laughing. Her past medical history was significant for asthma and she was on no medication. Neuro-logical examination was normal. MRI of the head and neck did not show a...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Shatti, D., Weatherby, S., Pace, A. Tags: Abstracts Source Type: research

Status epilepticus secondary to unusual encephalopathy
An 18-year-old girl presented urgently with recurrent focal seizures. The seizures start with myoclonic jerking of the left leg, spreading to the left arm and head. She had complained of mild migraine like headaches for the last 4 weeks and had had formal visual hallucinations. She had no past medical history. She was apyrexial, with continuous myoclonic activity of the left leg, arm and head, left homonymous hemianopia and left sided ataxia. Routine blood tests were normal or negative, HIV test was negative, MRI brain showed right parieto-occipital gyral swelling, CSF examination was normal with normal CSF lactate. Geneti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Ali, K., Flower, M., Lawthom, C. Tags: Abstracts Source Type: research

Patients' ideas and choices about the management of headache
This study aims to describe the views of patients, their fears, use of emergency departments, their perceived need for a scan and its future outcome for them. Methods A qualitative study using semi-structured interviews with 19 adults aged 23–63, referred by General Practitioners (GPs) to neurologists for primary headaches approximately two years previously. Audio-recorded interviews were transcribed and analysed thematically. Results Participants described fears about secondary organic causes for headache, like a brain tumour. They described their headaches as stressful, and leading to a vicious cycle of fear. Man...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Ridsdale, L., Noble, A., Nadeem, F., Morgan, M. Tags: Abstracts Source Type: research

Psychological interventions for migraine: systematic review
Migraine causes major health impairment and disability costing the UK over £2 billion annually. Psychological interventions offer an addition to pharmacotherapy, but are not currently available in the NHS. We aimed to systematically review evidence on the efficacy of psychological interventions for migraine in adults published since 1999, when the last systematic review was published. A search was done of MEDLINE and psychINFO, as well as www.opengrey.eu, the metaregister of controlled trials and bibliographies. 24 papers were included and rated independently by two people using the Yates scale, which has 35 points. ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Sullivan, A., Cousins, S., Ridsdale, L. Tags: Abstracts Source Type: research

From ataxia to bilateral facial palsy due to one virus
Discussion Neurological complications occur in up to 8% of patients with EBV infection. Although viral meningitis is the commonest presentation, it may result in encephalitis, cerebellitis, cranial nerve palsies, myelitis and neuropathies. Cerebrospinal fluid viral DNA testing is often negative and the diagnosis requires careful history-taking for preceding systemic symptoms. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Chinthapalli, V. K., Chinthapalli, S., Trend, P. Tags: Abstracts Source Type: research

Herpes simplex type 2 associated neurological syndromes
Three women with neurological syndromes associated with Herpes Simplex type 2 (HSV2), diagnosed by PCR, are presented. Patient 1 had lymphocytic meningitis with no antecedent or concurrent genital symptoms. Patient 2 had chronic lymphocytic meningitis in the context of immunosuppressive medication and Mollaret cells in the cerebrospinal fluid. She has persistent neurological symptoms despite prolonged treatment with intravenous acyclovir, cessation of immunosuppression and clearance of viral nucleic acid from the cerebrospinal fluid. Patient 3 had a 6 year history of a recurrent vesicular eruption in a dermatomal distribut...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Keshavan, A., Breen, D., Theodore, C., Misbahuddin, A., De Silva, R. Tags: Abstracts Source Type: research

The mind's eye
Had the Russian painter Wassily Kandinsky (figure 1) turned his hand to neuroscience rather than abstract art, he may well have been able to shed some light on an intriguing ivory artefact discovered in the Upper Palaeolithic site of Eliseevitchi, nestled between Kiev and his hometown of Moscow. The 21 000-year-old mammoth tusk is the subject of a fascinating article for JNNP by GD Schott,1 who argues that the piece presents something of a puzzle for archaeologists and neuroscientists, for there appears no convincing conclusion as to the origin of the intricate hexagonal pattern etched on the tusk's surface. There is conse...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Caldwell, C. E. Tags: Headache (including migraine) Editorial commentaries Source Type: research

The neuropsychiatry of tinnitus: a circuit-based approach to the causes and treatments available
In conclusion, a review of the literature demonstrates the varied neuropsychiatric manifestations of tinnitus. Imaging studies help to explain the mechanism of the association. However, more research is needed to elucidate the neurocircuitry underlying the association. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Minen, M. T., Camprodon, J., Nehme, R., Chemali, Z. Tags: Headache (including migraine), Pain (neurology), Stroke, Drugs: psychiatry, Personality disorders, Psychotic disorders (incl schizophrenia), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics), Ear, nose and throat/otolaryngology Source Type: research

Joint Hypermobility and Headache
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - September 8, 2014 Category: Neurology Authors: Brad T. Tinkle Tags: Headache Currents—Invited Commentary/Editorial Source Type: research

Transcutaneous Supraorbital NeuroStimulation (tSNS)
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - September 8, 2014 Category: Neurology Authors: Deborah Tepper Tags: Headache Toolbox Source Type: research

Late‐Breaking Abstracts
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - September 8, 2014 Category: Neurology Tags: Late‐Breaking Abstracts Source Type: research

Eager for better migraine therapies: Keep your (telcage)PANTs on
Pharmacologic therapies for migraine have traditionally been divided into 2 broad and distinct categories.1–3 Acute treatments are given at the time of a migraine attack to relieve pain and restore function. Preventive treatments are usually taken on a daily basis to reduce the frequency of headaches. Conventional wisdom suggests that the drugs used as acute treatments (i.e., triptans, ergot alkaloids, nonsteroidal anti-inflammatory agents) differ from the drugs used as preventive treatments (antiepilepsy drugs, β-blockers, calcium channel blockers, and antidepressants) in mechanism of action, pharmacokinetic pr...
Source: Neurology - September 8, 2014 Category: Neurology Authors: Lipton, R. B., Sandor, P. S. Tags: All Headache, Migraine EDITORIALS Source Type: research

Randomized controlled trial of the CGRP receptor antagonist telcagepant for migraine prevention
Conclusions: These data suggest a potential role for CGRP receptor antagonism in migraine prophylaxis. However, the observed aminotransferase elevations do not support the use of telcagepant for daily administration. Classification of evidence: This study provides Class II evidence that in patients with migraine, telcagepant taken daily reduces headache days by 1.4 days per month compared to placebo and causes 2.5% of patients to have elevations of serum ALT levels. (Source: Neurology)
Source: Neurology - September 8, 2014 Category: Neurology Authors: Ho, T. W., Connor, K. M., Zhang, Y., Pearlman, E., Koppenhaver, J., Fan, X., Lines, C., Edvinsson, L., Goadsby, P. J., Michelson, D. Tags: Migraine, Clinical trials Randomized controlled (CONSORT agreement), Class II ARTICLE Source Type: research