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Headache condition linked to weight-loss surgery
By reshaping the gastrointestinal tract, bariatric surgery appears to set in motion a cascade of physiological changes -- most obviously weight loss. But a new study suggests that such surgery may also be linked, in rare cases, to a headache condition caused by a leak of cerebrospinal fluid... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - October 24, 2014 Category: Science Source Type: news

Bariatric Surgery Linked to Intracranial HypotensionBariatric Surgery Linked to Intracranial Hypotension
Weight loss or micronutrient deficiency may set the stage for spinal fluid leaks causing a unique type of headache. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - October 23, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Local control after fractionated stereotactic radiation therapy for brain metastases
Abstract Stereotactic radiosurgery (SRS) is frequently used in the management of brain metastases, but concerns over potential toxicity limit applications for larger lesions or those in eloquent areas. Fractionated stereotactic radiation therapy (SRT) is often substituted for SRS in these cases. We retrospectively analyzed the efficacy and toxicity outcomes of patients who received SRT at our institution. Seventy patients with brain metastases treated with SRT from 2006–2012 were analyzed. The rates of local and distant intracranial progression, overall survival, acute toxicity, and radionecrosis were determine...
Source: Journal of Neuro-Oncology - October 23, 2014 Category: Cancer & Oncology Source Type: research

Weight-Loss Surgery May Raise Risk of Severe Headaches, Scientists Report
Title: Weight-Loss Surgery May Raise Risk of Severe Headaches, Scientists ReportCategory: Health NewsCreated: 10/22/2014 12:00:00 AMLast Editorial Review: 10/23/2014 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - October 23, 2014 Category: Neurology Source Type: news

Cluster headache in an elderly patient treated with neurofunctional acupuncture a case report
The objective of this report is to describe a low cost technique that can be applied in office by a doctor trained in neurofunctional acupuncture and can bring good results for patients with this debilitating disease. (Source: Acupuncture and Related Therapies)
Source: Acupuncture and Related Therapies - October 23, 2014 Category: Complementary Medicine Source Type: research

Is compassion a part of the non-specific effects of acupuncture?
Publication date: 2012 Source:Acupuncture and Related Therapies, Volume 1, Issue 1 Author(s): Thomas Lundeberg , Iréne Lund , Jan Näslund Acupuncture is widely used for the treatment of chronic (long-term) pain. In a recent study, Vickers et al. characterized the analgesic effect of acupuncture in four different chronic pain conditions, back and neck pain, osteoarthritis, headache, and shoulder pain, and concluded that acupuncture is an effective type of treatment for these chronic pain states. Significant differences between true and sham acupuncture indicate that acupuncture induces superior effects. However, these d...
Source: Acupuncture and Related Therapies - October 23, 2014 Category: Complementary Medicine Source Type: research

Methodological Issues in Studying Trigger Factors and Premonitory Features of Migraine
ConclusionEstablishing the relationship between antecedent events and headaches is a formidable challenge. Successfully addressing this challenge should provide insights into disease mechanisms and lead to new strategies for treatment. In the second paper in this series, we review the available literature on trigger factors and premonitory features. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 23, 2014 Category: Neurology Authors: Richard B. Lipton, Jelena M. Pavlovic, Sheryl R. Haut, Brian M. Grosberg, Dawn C. Buse Tags: Headache Currents—Clinical Review Source Type: research

A Double‐Blind, Placebo‐Controlled Study of Repetitive Transnasal Sphenopalatine Ganglion Blockade With Tx360® as Acute Treatment for Chronic Migraine
ConclusionSPG blockade with bupivacaine delivered repetitively for 6 weeks with the Tx360® device demonstrates promise as an acute treatment of headache in some subjects with CM. Statistically significant headache relief is noted at 15 and 30 minutes and sustained at 24 hours for SPG blockade with bupivacaine vs saline. The Tx360® device was simple to use and not associated with any significant or lasting adverse events. Further research on sphenopalatine ganglion blockade is warranted. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 23, 2014 Category: Neurology Authors: Roger Cady, Joel Saper, Kent Dexter, Heather R. Manley Tags: Research Submission Source Type: research

Factors Associated With Emergency Department Visits for Migraine: An Observational Study
ConclusionsMost migraineurs presenting to the ED have a PCP and health insurance. ED visits commonly result from an inability to access care elsewhere and because patients consider pain to be an emergency condition. Missed opportunities for diagnosis and treatment likely contribute to ED visits. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 23, 2014 Category: Neurology Authors: Mia T. Minen, Elizabeth Loder, Benjamin Friedman Tags: Research Submission Source Type: research

Prevalence of migraine headache in an in‐patient stroke population
ConclusionsThe prevalence of migraine in this hospital‐based stroke cohort was comparable to the estimated prevalence of migraine usually described in population studies. In our study population, the prevalence of migraine with aura was higher than expected. The increased prevalence of PFO in patients with migraine headache corresponds well to previous population studies. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 23, 2014 Category: Neurology Authors: M. Lantz, K. Kostulas, E. Waldenlind, C. Sjöstrand Tags: Original Article Source Type: research

Burden and cost of neurological diseases: a European North–South comparison
ConclusionsHealth expenditure, YLDs, costs and prevalence of neurological conditions were generally not correlated across the eight countries. A clear North–South gradient was found for health expenditures, and partially for YLDs, costs and diseases' prevalence. We hypothesized that this is a consequence of the expansion of morbidity of neurological conditions connected to ageing, that health and welfare systems of selected countries were not prepared to face. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 23, 2014 Category: Neurology Authors: A. Raggi, M. Leonardi Tags: Original Article Source Type: research

Weight-Loss Surgery May Raise Risk of Severe Headaches, Scientists Report
But experts find the study too small, problem too rare to be of concern Source: HealthDay Related MedlinePlus Pages: Headache, Low Blood Pressure, Weight Loss Surgery (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - October 22, 2014 Category: Consumer Health News Source Type: news

Comparison of the pharmacokinetic and pharmacodynamic properties of two recombinant granulocyte colony-stimulating factor formulations after single subcutaneous administration to healthy volunteers.
CONCLUSIONS: The study results demonstrated the bioequivalence of Gp-02, a new formulation of filgrastim, and the reference product Neupogen™. PMID: 25323541 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 22, 2014 Category: Universities & Medical Training Authors: Sveikata A, Gumbrevičius G, Seštakauskas K, Kregždytė R, Janulionis V, Fokas V Tags: Medicina (Kaunas) Source Type: research

SINUS CONGESTION HEADACHE (Not Applicable) Spray [Liddell Laboratories, Inc.]
Updated Date: Oct 22, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 22, 2014 Category: Drugs & Pharmacology Source Type: news

When heart cancer hides in the brain
(ecancermedicalscience) The 59-year-old woman had complained of chest pain and shortness of breath. A biopsy revealed that she had an unusual type of 'heart cancer' called cardiac lymphoma. But a week after receiving treatment, the patient developed a headache and her motor skills began to deteriorate. Fortunately, doctors at the institute had seen a similar strange case just two years before. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 22, 2014 Category: Cancer & Oncology Source Type: news

Surgical anatomy of greater occipital nerve and its relation to occipital artery
Conclusion The knowledge of the anatomy of greater occipital nerve and its relation to occipital artery is important for the surgeon. Blockage or surgical release of greater occipital nerve is clinically effective in eliminating chronic migraine headache. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - October 22, 2014 Category: Journals (General) Source Type: research

Data bank struggles as protein imaging ups its game
Nature 514, 7523 (2014). http://www.nature.com/doifinder/10.1038/514416a Author: Ewen Callaway Hybrid methods to solve structures of molecular machines create a storage headache. (Source: Nature)
Source: Nature - October 22, 2014 Category: Research Authors: Ewen Callaway Tags: News Source Type: research

Inadvertent High-dose Therapy With Temozolomide in a Child With Recurrent Pontine Glioma Followed by a Rapid Clinical Response But Deteriorated After Substitution With Low-dose Therapy
We present a case of inadvertent high-dose therapy with temozolomide in a child with recurrent diffuse intrinsic pontine glioma followed by a rapid clinical response. The patient was a 7-year-old boy who initially presented with a history of left facial palsy, double vision, headache, and ataxia. His symptoms were completely resolved following radiotherapy but recurred 3 months after. Following recurrence, he received temozolomide in a dose >3 times higher than prescribed inadvertently but tolerated well with a rapid clinical response. He eventually deteriorated after he was substituted with a lower dose of temozolomide an...
Source: Journal of Pediatric Hematology Oncology - October 21, 2014 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

Accelerated hypertension after venlafaxine usage.
We report a patient with accelerated hypertension after venlafaxine use observed at a dose of 150 mg/day. A 23-year-old patient with symptoms of insomnia, depression, anhedonia, fatigue admitted our clinic. Venlafaxine at a dose of 75 mg/day was initiated after he was diagnosed with major depressive disorder. After 5 months, venlafaxine dose was uptitrated to 150 mg/day due to inadequate response to drug. After using venlafaxine for ten months at the dose of 150 mg/day, he admitted our clinic with headache and epistaxis. He was hospitalized after his blood pressure was measured as 210/170 mmHg. No secondary cause...
Source: Case Reports in Psychiatry - October 21, 2014 Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research

EXCEDRIN TENSION HEADACHE PAIN RELIEVER (Acetaminophen And Caffeine) Tablet, Film Coated [Novartis Consumer Health, Inc.]
Updated Date: Oct 21, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 21, 2014 Category: Drugs & Pharmacology Source Type: news

Transcranial bright light treatment via the ear canals in seasonal affective disorder: a randomized, double-blind dose-response study
Conclusions: These results suggests that transcranial bright light treatment may have antidepressant and anxiolytic effect in SAD patients, as both self- and psychiatrist-rated depressive and anxiety symptoms decreased in all treatment groups. These improvements are comparable to findings of earlier bright light studies that used conventional devices. The lack of dose response may be due to a saturation effect above a certain light intensity threshold. Further studies on the effects of transcranial bright light with an adequate placebo condition are needed.Trial registrationNCT01293409, ClinicalTrials.gov (Source: BMC Psychiatry)
Source: BMC Psychiatry - October 21, 2014 Category: Psychiatry Authors: Heidi JurvelinTimo TakalaJuuso NissiläMarkku TimonenMelanie RügerJari JokelainenPirkko Räsänen Source Type: research

A New Reversible and Potent P2Y 12 Receptor Antagonist (ACT-246475): Tolerability, Pharmacokinetics, and Pharmacodynamics in a First-in-Man Trial
Conclusions Oral doses of ACT-281959 and ACT-246475 were well tolerated. Platelet inhibition correlated with ACT-246475 exposure. Exploratory formulations enhanced the bioavailability and antiplatelet effect of ACT-246475. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 21, 2014 Category: Drugs & Pharmacology Source Type: research

Depression, anxiety and stress among pregnant Migraineurs in a pacific-northwest cohort
The co-occurrence of migraine and unipolar psychiatric disorders has been well documented in non-pregnant populations, however little is known in pregnant populations. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - October 21, 2014 Category: Neurology Authors: Olivia R. Orta, Bizu Gelaye, Chungfang Qiu, Lee Stoner, Michelle A. Williams Tags: Research report Source Type: research

Children Who Go to School in Pain
Imagine pain like an ice pick through your head, vertigo, and nausea. Imagine that a cat's footpad sounded so loud your eardrums felt like they were being sandpapered and the overhead lights felt like a harsh flashlight in your eyes when you've been hiding in the dark. Now imagine yourself in the middle of a high school corridor when classes are changing.read more (Source: Psychology Today Parenting Center)
Source: Psychology Today Parenting Center - October 20, 2014 Category: Psychiatry & Psychology Authors: Nancy Darling, Ph.D. Tags: Child Development Education Health Parenting adolescence chronic pain disability migraine Source Type: news

Viagra could double up as heart failure drug
ConclusionThis systematic review of 24 RCTs indicated PDE5is were more effective than placebos at improving specific measures of heart health and were broadly safe.PDE5is lower blood pressure, so these drugs are currently contraindicated or used with caution in people with cardiovascular disease, including those with low blood pressure and a history of stroke or heart attack, as the effects are unknown. However, various research studies have continued to investigate the possibility that these drugs could have a beneficial effect on heart function. This review has looked into their effect on cardiovascular outcomes further ...
Source: NHS News Feed - October 20, 2014 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials
Conclusions: This meta-analysis suggests for the first time that PDE5i have anti-remodeling properties and improve cardiac inotropism, independently of afterload changes, with a good safety profile. Given the reproducibility of the findings and tolerability across different populations, PDE5i could be reasonably offered to men with cardiac hypertrophy and early stage heart failure. Given the limited gender data, a larger trial on the sex-specific response to long-term PDE5i treatment is required. (Source: BMC Medicine)
Source: BMC Medicine - October 20, 2014 Category: Internal Medicine Authors: Elisa GiannettaTiziana FeolaDaniele GianfrilliRiccardo PofiValentina Dall¿ArmiRoberto BadagliaccaFederica BarbagalloAndrea LenziAndrea Isidori Source Type: research

Two formulations of epoprostenol sodium in the treatment of pulmonary arterial hypertension: EPITOME-1 (epoprostenol for injection in pulmonary arterial hypertension), a phase IV, open-label, randomized study
Conclusions In this randomized clinical study of epoprostenol AM in PAH, use of this novel preparation with greater room temperature stability was well tolerated. (Source: American Heart Journal)
Source: American Heart Journal - October 20, 2014 Category: Cardiology Source Type: research

Best practice guidelines on publishing ethics: a publisher's perspective, 2nd edition
Wiley has updated its publishing ethics guidelines, first published in 2006. The new guidelines provide guidance, resources, and practical advice on ethical concerns that arise in academic publishing for editors, authors, and researchers, among other audiences. New guidance is also included on whistle blowers, animal research, clinical research, and clinical trial registration, addressing cultural differences, human rights, and confidentiality. The guidelines are uniquely interdisciplinary and were reviewed by 24 editors and experts chosen from the wide range of communities that Wiley serves. The new guidelines are also pu...
Source: Annals of the New York Academy of Sciences - October 20, 2014 Category: Science Authors: Chris Graf, Lisa Deakin, Martine Docking, Jackie Jones, Sue Joshua, Tiffany McKerahan, Martin Ottmar, Allen Stevens, Edward Wates, Deborah Wyatt Tags: Other Paper Source Type: research

Corrigendum
In the article “Management of Pediatric Migraine in a Tertiary Care Versus Community Based Emergency Department: An Observational Pilot Study” by Eapen et al. in the February 2014 issue (2014;50:164-170; http://dx.doi.org/10.1016/j.pediatrneurol.2013.10.005), the authors were listed in the wrong order. The corrected author line appears below. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 19, 2014 Category: Neurology Tags: Corrigendum Source Type: research

The thalamic reticular nucleus is activated by cortical spreading depression in freely moving rats: prevention by acute valproate administration
This study investigated the effect of repetitive cortical spreading depression (CSD) on behaviour and the anatomical and physiological patterns of cellular activation of cortical and subcortical areas in awake, moving rats. Rat behaviours in response to repetitive CSD events evoked by the application of KCl were quantified with electrophysiological recording. Immunohistochemistry was used to quantify anatomical regions of cellular activation. The effects of acute valproic acid administration on the behavioural parameters and cellular activation were evaluated. CSD significantly decreased locomotor activity and induced free...
Source: European Journal of Neuroscience - October 18, 2014 Category: Neuroscience Authors: Nermin Tepe, Aslı Filiz, Ergin Dilekoz, Didem Akcali, Yildirim Sara, Andrew Charles, Hayrunnisa Bolay Tags: Research Report Source Type: research

Pediatric migraine: common, yet treatable
Abstract:Migraine headache is a common problem among children and adolescents that is now recognized as a significant and often debilitating condition in this population. Improved recognition and management of pediatric migraine in primary care is necessary, as there is a knowledge gap in understanding the unique features of this condition and a general reluctance to treat children. (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - October 17, 2014 Category: Nursing Tags: Feature: HEADACHES Source Type: research

Pediatric migraine: common, yet treatable
No abstract available (Source: The Nurse Practitioner)
Source: The Nurse Practitioner - October 17, 2014 Category: Nursing Tags: CE Connection Source Type: research

A pain in the neck
A 41-year-old woman presented to the emergency department after developing severe neck pain while unloading groceries. The pain began at the base of her neck, radiated to the vertex of the skull, reached maximum intensity within 2–3 min, and was aggravated by head movement. Neurological examination was normal. Head CT showed focal hyperattenuation immediately anterior to the midbrain (figure 1) and angiogram showed no evidence of aneurysm (see online supplementary figure 1). Diagnosis: Perimesencephalic nonaneurysmal subarachnoid haemorrhage (PN-SAH). Originally described in 1985,1 PN-SAH has been reported in pa...
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Lindor, R. A., Homme, J. L. Tags: Headache (including migraine), Pain (neurology), Stroke, Ethics Images in emergency medicine Source Type: research

Topical Review: Behavioral Economics as a Promising Framework for Promoting Treatment Adherence to Pediatric Regimens
Conclusions BE offers pediatric psychology not only low-intensity approaches for promoting adherence but also highly attractive ways of obtaining the attention of health care administrators and policymakers. (Source: Journal of Pediatric Psychology)
Source: Journal of Pediatric Psychology - October 17, 2014 Category: Pediatrics Authors: Stevens, J. Tags: Topical Reviews Source Type: research

Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients With Neurosyphilis and HIV Infection.
Abstract Periodic lateralized epileptiform discharges (PLEDs) are an electroencephalographic pattern recorded in the setting of a variety of brain abnormalities. It is best recognized for its association with acute viral encephalitis, stroke, tumor, or latestatus epilepticus. However, there are other conditions that have been recognized as the underlying pathology for PLEDs such as alcohol withdrawal, Creutzfeldt-Jacob disease, anoxic brain injury, and hemiplegic migraine. However, there are only rare case reports of PLEDs in patients with neurosyphilis. Here, we report 2 patients presenting with encephalopathy and...
Source: Clinical EEG and Neuroscience - October 17, 2014 Category: Neuroscience Authors: Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK Tags: Clin EEG Neurosci Source Type: research

New drug-free treatment helps combat painful migraines
Cefaly, a high-tech headband device, has shown promise preventing migraine headaches. Kathy Walsh of KCNC reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 16, 2014 Category: Consumer Health News Source Type: news

Breastfeeding and migraine drugs
Conclusions According to our review, the majority of the revised AMDs were assessed to be compatible with breastfeeding. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - October 16, 2014 Category: Drugs & Pharmacology Source Type: research

Images From Headache: Acute Headache With a Reversible Splenium Lesion
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: David Schick, Matthew S. Robbins Tags: Images From Headache Source Type: research

Symptomatic Lacrimal Neuralgia After Ophthalmic Surgery
ConclusionLacrimal neuralgia may be due to local trauma. This new case not only reinforces the existence of a specific neuralgia of the lacrimal nerve, but also introduces a classification into primary and secondary forms based on the etiology. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: María‐Luz Cuadrado, Ángel Aledo‐Serrano Tags: Brief Communication Source Type: research

From Wakefulness to Sleep: Migraine and Hypnic Headache Association in a Series of 23 Patients
ConclusionA history of migraine is common in HH patients in our series. Most frequent transition pattern was an immediate change between both syndromes. Hypnic headache and migraine might share a common pathophysiological predisposition. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Marina Ruiz, Patricia Mulero, María Isabel Pedraza, Carolina Cruz, Cristina Rodríguez, Irene Muñoz, Johanna Barón, Angel Luis Guerrero Tags: Brief Communication Source Type: research

Changes of Migraine‐Related White Matter Hyperintensities After 3 Years: A Longitudinal MRI Study
ConclusionsThis longitudinal MRI study found clinically silent brain white matter hyperintensities to be predominantly progressive in nature. The absence of a control group precludes definitive conclusions about the nature of these changes or if their degree is beyond normal aging. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Szilvia Erdélyi‐Bótor, Mihály Aradi, David Olayinka Kamson, Norbert Kovács, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Attila Schwarcz, Tamás Dóczi, Sámuel Komoly, Gabriella Deli, Anita Trauninger, Zoltán Pfund Tags: Research Submission Source Type: research

Statistical Testing of Association Between Menstruation and Migraine
ConclusionsIn this paper, we correct a proposed method for establishing association between menstruation and migraine by statistical methods. We conclude that the proposed standard of 3‐cycle observations prior to setting an MRM diagnosis should be extended with at least one perimenstrual window to obtain sufficient information for statistical processing. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Mathias Barra, Fredrik A. Dahl, Kjersti G. Vetvik Tags: Research Submission Source Type: research

Measuring the Social Media Impact of Your Headache Article
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Jason Roberts Tags: From the Editorial Office Source Type: research

Headache (@HeadacheJournal) and Twitter
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Matthew S. Robbins, Todd J. Schwedt, Thomas N. Ward, Jason Roberts Tags: From the Editorial Office Source Type: research

Insights on Treatment Mechanisms of Cognitive‐Behavioral Migraine Therapy
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Donald B. Penzien, Megan B. Irby Tags: Guest Editorial Source Type: research

KCNK18 (TRESK) Genetic Variants in Italian Patients With Migraine
ConclusionsOur study shows the presence of several KCNK18 gene mutations in both migraine with aura and migraine without aura. However, the precise role of this gene in migraine predisposition deserves further studies. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Innocenzo Rainero, Elisa Rubino, Salvatore Gallone, Paola Zavarise, Daniela Carli, Silvia Boschi, Pierpaola Fenoglio, Lidia Savi, Salvatore Gentile, Paolo Benna, Lorenzo Pinessi, Giorgio Dalla Volta Tags: Research Submission Source Type: research

Sumatriptan Iontophoretic Patch for Migraine
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - October 16, 2014 Category: Neurology Authors: Deborah E. Tepper Tags: Headache Toolbox Source Type: research

CADASIL and CARASIL
Abstract CADASIL and CARASIL are hereditary small vessel diseases leading to vascular dementia. CADASIL commonly begins with migraine followed by minor strokes in mid‐adulthood. Dominantly inherited CADASIL is caused by mutations (n > 230) in NOTCH3 gene, which encodes Notch3 receptor expressed in vascular smooth muscle cells (VSMC). Notch3 extracellular domain (N3ECD) accumulates in arterial walls followed by VSMC degeneration and subsequent fibrosis and stenosis of arterioles, predominantly in cerebral white matter, where characteristic ischemic MRI changes and lacunar infarcts emerge. The likely pathogenesis of...
Source: Brain Pathology - October 16, 2014 Category: Neurology Authors: Saara Tikka, Marc Baumann, Maija Siitonen, Petra Pasanen, Minna Pöyhönen, Liisa Myllykangas, Matti Viitanen, Toshio Fukutake, Emmanuel Cognat, Anne Joutel, Hannu Kalimo Tags: MINI‐SYMPOSIUM: Pathology & Genetics of (non‐CAA) Cerebral Microvascular Disease Source Type: research

Part II- Management of Pediatric Posttraumatic Headaches
Posttraumatic headache is one of the most common symptoms occurring after mild traumatic brain injury in children. (Source: Pediatric Neurology)
Source: Pediatric Neurology - October 16, 2014 Category: Neurology Authors: Elana Pinchefsky, Alexander Sasha Dubrovsky, Debbie Friedman, Michael Shevell Tags: Topical Review Source Type: research