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Peripheral neuromodulation: a review.
Abstract Peripheral nerve stimulation (PNS) is likely the most diverse and rapidly expanding area of neuromodulation. Its expansion has become possible due to both technological and clinical advances in pain medicine. The first implantable systems were surgically placed. However, it is currently commonplace to use percutaneous leads, as this approach has become instrumental in its expansion. The first percutaneous peripheral nerve stimulators were reported in 1999. Cylindrical leads were implanted to stimulate the greater occipital nerve to manage intractable headache. It has been expanded into other individual ner...
Source: Epilepsy Curr - April 2, 2014 Category: Neurology Authors: Goroszeniuk T, Pang D Tags: Curr Pain Headache Rep Source Type: research

FDA Clears First Medical Device for Preventing Migraine Headaches
(Source: MDDI)
Source: MDDI - April 1, 2014 Category: Medical Equipment Authors: Jamie Hartford Tags: Washington Wrap-Up Regulatory and Compliance Source Type: news

Topamax Approval for Migraines Expanded to Younger Users
Title: Topamax Approval for Migraines Expanded to Younger UsersCategory: Health NewsCreated: 3/31/2014 12:36:00 PMLast Editorial Review: 4/1/2014 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - April 1, 2014 Category: Neurology Source Type: news

Overuse of brain scans for American headache sufferers costs $1 billion per year
(Source: NaturalNews.com)
Source: NaturalNews.com - April 1, 2014 Category: Consumer Health Advice Source Type: news

Stabbing Headache in an 8-Year-Old Girl: Primary or Drug Induced Headache?
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of the headache, or possibly a link to physical activity. The current study describes the case of an 8-year-old girl who suffered short-lasting stabbing headache attacks. The headaches with increasing intensity and frequency started 1 month before her hospitalization and were usually preceded by physical activity (dancing, running). The pain, which was lo...
Source: PEDIATRICS - April 1, 2014 Category: Pediatrics Authors: Biedroł, A., Kaciłski, M., Skowronek-Bała, B. Tags: Case Report Source Type: research

Topiramate use in pregnancy and the birth prevalence of oral clefts
ConclusionConsistent with other recent epidemiologic research, first‐trimester TPM exposure was associated with an elevated birth prevalence of OC. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - April 1, 2014 Category: Drugs & Pharmacology Authors: Daniel Mines, Patricia Tennis, Suellen M. Curkendall, De‐Kun Li, Craig Peterson, Elizabeth B. Andrews, Brian Calingaert, Hong Chen, Gaurav Deshpande, Daina B. Esposito, Nicholas Everage, Crystal N. Holick, Nicole M. Meyer, Ella T. Nkhoma, Sherry Quinn, Tags: Original Report Source Type: research

What the Nonneurologist Can Do to Treat Headache.
Abstract Nonneurologists who treat patients with headaches should be able recognize common headache types and to initiate therapy for tension-type headaches and migraines. Patients with complicated headache scenarios should be referred to a neurologist for consultation. PMID: 24680491 [PubMed - as supplied by publisher] (Source: The Medical Clinics of North America)
Source: The Medical Clinics of North America - April 1, 2014 Category: Journals (General) Authors: Jamieson DG Tags: Otolaryngol Clin North Am Source Type: research

Teaching NeuroImages: Internal carotid artery dissection presenting as Villaret syndrome
A 63-year-old man presented with headache, hoarseness, and dysphagia. He had a left-sided Horner syndrome and wasting of the left sternocleidomastoid muscle. His tongue was deviated to the left on protrusion (figure 1). MRI and CT angiography revealed a distal left internal carotid artery dissection (figure 2). (Source: Neurology)
Source: Neurology - March 31, 2014 Category: Neurology Authors: Okpala, O., Von Essen, A., Cummins, G., Manford, M. Tags: All Imaging, All Cerebrovascular disease/Stroke, Cranial neuropathy, Carotid artery dissection RESIDENT AND FELLOW SECTION Source Type: research

Topiramate Approved for Migraine Prevention in Adolescents (FREE)
By Amy Orciari Herman The FDA has approved the antiepileptic topiramate (Topamax) to prevent migraine in adolescents aged 12 to 17, the agency announced on Friday. It's the first drug approved for … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 31, 2014 Category: Primary Care Source Type: news

[Cluster-like headache due to dissection of the internal carotid artery after Pilates training.]
PMID: 24682169 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)
Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Weber R, Grab J, Berlit P, Gaul C Tags: Nervenarzt Source Type: research

FDA Okays First Drug for Migraine Prevention in AdolescentsFDA Okays First Drug for Migraine Prevention in Adolescents
The FDA has approved topiramate for prophylaxis of migraine in adolescents aged 12 to 17, the first such approval for this age group. FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 29, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Functional polymorphisms in COMT and SLC6A4 genes influence the prognosis of patients with medication overuse headache after withdrawal therapy
ConclusionsOur results indicate that genotyping for COMT rs4680 and SLC6A4 STin2 VNTR could be useful for the identification of MOH patients at higher risk of poor prognosis after drug withdrawal. (Source: European Journal of Neurology)
Source: European Journal of Neurology - March 29, 2014 Category: Neurology Authors: S. Cargnin, M. Viana, N. Ghiotto, M. Bianchi, G. Sances, C. Tassorelli, G. Nappi, P. L. Canonico, A. A. Genazzani, S. Terrazzino Tags: Original Article Source Type: research

Index
Note: Page numbers of article titles are in boldface type. Antidepressants, in chronic migraine, 231–232 (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - March 28, 2014 Category: ENT & OMF Source Type: research

The Otolaryngologist’s Challenge: The Differential Diagnosis of the Positive Scan
As advanced imaging became available and the technology progressed to provide more and more highly detailed images of the nervous system, it was often joked that the role of the neurologist would become diminished and relegated to providing a differential diagnosis for the negative scan. Obviously, this dire prediction for neurology never came to fruition. In rhinogenic headache, the tables have clearly been turned, and the challenge for the otolaryngologist has become that of providing a differential diagnosis for a positive scan. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - March 28, 2014 Category: ENT & OMF Authors: Curtis P. Schreiber Source Type: research

Evaluation and Management of “Sinus Headache” in the Otolaryngology Practice
Patients, primary care doctors, neurologists and otolaryngologists often have differing views on what is truly causing headache in the sinonasal region. This review discusses common primary headache diagnoses that can masquerade as “sinus headache” or “rhinogenic headache,” such as migraine, trigeminal neuralgia, tension-type headache, temporomandibular joint dysfunction, giant cell arteritis (also known as temporal arteritis) and medication overuse headache, as well as the trigeminal autonomic cephalalgias, including cluster headache, paroxysmal hemicrania, and hemicrania continua. Diagnostic criteria are discusse...
Source: Otolaryngologic clinics of North America - March 28, 2014 Category: ENT & OMF Authors: Zara M. Patel, Michael Setzen, David M. Poetker, John M. DelGaudio Source Type: research

Study: Scans for headache way overused
It’s Friday, time for a little medical madness. Never mind that the practice is costly and unnecessary, never mind the radiation exposure, around $1 billion is spent every year on medical scans for people who go to their doctor with a headache. What’s more, referrals for head scans for headaches is actually increasing, even though many guidelines recommend against routine neuroimaging for headache, according to an article that appears in the journal JAMA Internal Medicine. And many studies… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 28, 2014 Category: American Health Authors: Kris B. Mamula Source Type: research

FDA approves Topamax for migraine prevention in adolescents
Today, the U.S. Food and Drug Administration approved Topamax (topiramate) for prevention (prophylaxis) of migraine headaches in adolescents ages 12 to 17. This is the first FDA approval of a drug for migraine prevention in this age group. The medication is taken on a daily basis to reduce the frequency of migraine headaches. (Source: Food and Drug Administration)
Source: Food and Drug Administration - March 28, 2014 Category: American Health Source Type: news

Exploration of antagonist CP-376395 escape pathway for the corticotropin-releasing factor receptor 1 by random acceleration molecular dynamics simulations
Mol. BioSyst., 2014, Accepted ManuscriptDOI: 10.1039/C4MB00037D, PaperQifeng Bai, Danfeng Shi, Yang Zhang, Huanxiang Liu, Xiaojun YaoCorticotropin-releasing factor receptor 1 (CRF1R), one member of class B G-protein-coupled receptors (GPCRs), plays an important role in the treatment of osteoporosis, diabetes, depression, migraine and anxiety. To explore the...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Mol. BioSyst. latest articles)
Source: RSC - Mol. BioSyst. latest articles - March 28, 2014 Category: Molecular Biology Authors: Qifeng Bai Source Type: research

[Case Report] Giant cell arteritis
In July 2013, a 64-year-old woman presented to her optometrist with a 4-day history of intermittent blurred vision in the left eye with a left-sided headache. The patient was unsure whether she had had jaw claudication or scalp tenderness. She had no previous ocular history except spectacles for hyperopia and presbyopia. She had been taking diclofenac, tramadol, omeprazole, alendronic acid, calcium supplements, and glyceryl trinitrate spray. Her best corrected visual acuity was 6/6 in the right eye and 6/60 in the left eye. (Source: LANCET)
Source: LANCET - March 28, 2014 Category: Journals (General) Authors: Colm McAlinden, Pantelis Ioannidis, Shaun Roberts, Eirini Skiadaresi Tags: Case Report Source Type: research

Interference from heterophilic antibodies in D-dimer assessment. A case report
We describe the case of a 3-year-old girl, admitted to the pediatric ward for three repeated episodes of severe migraine associated with vertigo, with onset 1 week after complete remission from an episode of chicken pox (i.e., varicella-zoster virus infection). All radiological and laboratory examinations were normal, except for a markedly elevated value of D-dimer (i.e. 8998 ng/ml; local reference range:  (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - March 28, 2014 Category: Hematology Tags: Case Reports Source Type: research

US FDA accepts Avanir's NDA for AVP-825 to treat migraine
The US Food and Drug Administration (FDA) has accepted Avanir Pharmaceuticals' new drug application (NDA) of its breath-powered investigational drug-device combination product AVP-825 for the acute treatment of migraine. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - March 28, 2014 Category: Pharmaceuticals Source Type: news

US FDA accepts Avanir's NDA for AVP-825 to treat migraines
The US Food and Drug Administration (FDA) has accepted Avanir Pharmaceuticals' new drug application (NDA) of its breath-powered investigational drug-device combination product AVP-825 for the acute treatment of migraines. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - March 28, 2014 Category: Pharmaceuticals Source Type: news

A replication study of GWAS findings in migraine identifies association in a Swedish case-control sample
Conclusions: This is the first reported genetic association study of a Swedish migraine case control material. We have thus replicated findings of susceptibility loci for migraine in an independent genetic material, thereby increasing knowledge about genetic risk factors for this common neurological disorder. (Source: BMC Medical Genetics - Latest articles)
Source: BMC Medical Genetics - Latest articles - March 28, 2014 Category: Genetics & Stem Cells Authors: Caroline RanLisette GraaePatrik MagnussonNancy PedersenLars OlsonAndrea Belin Source Type: research

Clinical effectiveness of manual therapy for the management of musculoskeletal and non-musculoskeletal conditions: systematic review and update of UK evidence report
Conclusions: Overall, there was limited high quality evidence for the effectiveness of manual therapy. Most reviewed evidence was of low to moderate quality and inconsistent due to substantial methodological and clinical diversity. Areas requiring further research are highlighted. (Source: Chiropractic and Osteopathy)
Source: Chiropractic and Osteopathy - March 28, 2014 Category: Complementary Medicine Authors: Christine ClarAlexander TsertsvadzeRachel CourtGillian HundtAileen ClarkePaul Sutcliffe Source Type: research

Improvement in Sensorineural Hearing Loss During Pregnancy.
CONCLUSION: This case is unique in documenting improvements in hearing thresholds during pregnancy and substantiates the effects of hormonal changes on hearing thresholds in humans. It raises the intriguing possibility of hormonal therapy as a treatment for sensorineural hearing loss in specific clinical situations. PMID: 24682732 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - March 28, 2014 Category: ENT & OMF Authors: Stevens MN, Hullar TE Tags: Ann Otol Rhinol Laryngol Source Type: research

A replication study of GWAS findings in migraine identifies association in a Swedish case¿control sample
Conclusions: This is the first reported genetic association study of a Swedish migraine case control material. We have thus replicated findings of susceptibility loci for migraine in an independent genetic material, thereby increasing knowledge about genetic risk factors for this common neurological disorder. (Source: BMC Medical Genetics - Latest articles)
Source: BMC Medical Genetics - Latest articles - March 28, 2014 Category: Genetics & Stem Cells Authors: Caroline RanLisette GraaePatrik MagnussonNancy PedersenLars OlsonAndrea Belin Source Type: research

Headaches after Traumatic Brain Injury
Headache is one of the most common symptoms after a traumatic brain injury (TBI). They affect over 30% of individuals who have a TBI. Headaches can come and go, with varying frequency and intensity, for more than a year after injury. Headaches can make it more difficult to think, remember things, and carry out daily activities. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - March 27, 2014 Category: Rehabilitation Authors: Kathleen R. Bell, Jeanne Hoffman, Homas Watanabe Tags: Information/Education Page Source Type: research

Can a Placebo Stop a Migraine?
I heard about a study showing that taking a placebo works as well as prescription drugs at stopping migraine headaches. Can you please explain how this can happen? (Source: Dr. Weil Q and A)
Source: Dr. Weil Q and A - March 27, 2014 Category: Consumer Health Advice Source Type: news

A2: Rapid and Sustained Response in Patients Suffering From Severe Cryopyrin‐Associated Periodic Syndromes Treated With Anakinra (Kineret®)
Conclusion:All patients experienced a rapid response to the anakinra treatment, both initially and after a flare caused by the withdrawal phase. The response was maintained up to 60 months. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Mika Leinonen, Bengt Hallén, Hans Olivecrona Tags: Poster Presentations Source Type: research

A3: Efficacy and Safety of Adalimumab in Pediatric Patients With Enthesitis Related Arthritis
Conclusion:ADA reduced the signs and symptoms of ERA at wk 12 and efficacy was sustained up to 52 wks. The safety profile observed in pediatric patients with ERA was consistent with that observed in children aged ≥2 years treated for polyarticular JIA. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Ruben Burgos‐Vargas, Shirley ML Tse, Gerd Horneff, Aileen L. Pangan, Kristina Unnebrink, Jaclyn K. Anderson Tags: Poster Presentations Source Type: research

A40: Periodic Fever Syndromes in Canada: Results from a National Surveillance Program
Conclusion:Although rare periodic fever syndromes are identified across Canada each year. PFAPA, Undefined fever syndromes, and FMF are most frequently seen. We hope to have a more complete picture of the full spectrum and incidence of these autoinflammatory diseases in the Canadian population as genetic test results become available, and additional cases are identified through the end of the study in September 2014. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Paul Dancey, Susann Benseler, Marco Gattorno, Anne K Junker, Ronald M. Laxer, Paivi Miettunen, Lesley Ann Turner Tags: Poster Presentations Source Type: research

A64: Patient‐Reported Side Effects with Weekly Injections of Methotrexate in Tertiary Care Rheumatology Clinic
Conclusion:More than half of the patients reported at least one side effect that could be attributed to methotrexate injections; the most frequent ones were nausea and vomiting. Importantly, most side effects resolved within 24hours and patients reported excellent compliance. In general, patients did not have a preference for oral methotrexate. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Melanie Bechard, Julie Lemieux, Johannes Roth, Karen Watanabe Duffy, Ciaran M. Duffy, Mary Aglipay, Nick Barrowman, Roman Jurencak Tags: Poster Presentations Source Type: research

A84: Changes over Time in Symptoms and Treatment of Juvenile Primary Fibromyalgia Syndrome
Conclusion:Children with JPFS exhibit worsening pain and quality of life over time regardless of treatment modality recommendations or patient compliance to therapy. Patients returning for follow‐up visits may be those whose symptoms are most refractory. Additional studies are needed to identify barriers to improvement in this patient population and to determine effective treatment approaches to improve health outcomes. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Mark Connelly, Cara Hoffart, Kenneth Schikler, Alexis Boneparth, Jennifer E. Weiss Tags: Poster Presentations Source Type: research

A103: Childhood Onset Takayasu Arteritis—Experience From a Tertiary Care Centre in South India
Conclusion:Corticosteroids and immunosuppressive therapy were effective in the control of disease activity. Progression of damage was associated with persistent inflammation. Continued surveillance by clinical instruments and imaging is warranted. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Sathish Kumar, Ruchika Goel, Debashish Danda, Ajith Kumar Surin, Paul A Bacon Tags: Poster Presentations Source Type: research

Assessment of Tacrolimus Absorption From the Human Intestinal Tract: Open-Label, Randomized, 4-Way Crossover Study.
CONCLUSIONS: Tacrolimus was absorbed from the duodenum to the colon in these male subjects, although differences were observed in the value of AUC0-24, possibly due to variation in cytochrome P450 3A4 activity in the intestine. Although this study was conducted in small group of healthy fasting men, the present results indicate that tacrolimus is suitable for MR formulation development due to a wide absorption window throughout the intestine in humans. PMID: 24680768 [PubMed - as supplied by publisher] (Source: Clinical Therapeutics)
Source: Clinical Therapeutics - March 27, 2014 Category: Drugs & Pharmacology Authors: Tsunashima D, Kawamura A, Murakami M, Sawamoto T, Undre N, Brown M, Groenewoud A, Keirns JJ, Holman J, Connor A, Wylde H, Wilding I, Ogawara KI, Sako K, Higaki K, First R Tags: Clin Ther Source Type: research

NICE: 'schools should provide morning-after pill'
Conclusion Everyone makes mistakes, but if you find yourself relying on the morning-after pill as a regular method of contraception, you may want to speak to a healthcare professional about what would be the most suitable form of ongoing contraception for you to use. This could include methods that do not involve needing to take a daily pill, such as contraceptive patches, injections or an implant. However, none of these methods will protect you against sexually transmitted infections (STIs). Condoms are cheap, free of side effects and they will protect you against STIs such as chlamydia. For more information about your ...
Source: NHS News Feed - March 26, 2014 Category: Consumer Health News Tags: QA articles Pregnancy/child Source Type: news

Migraine attacks increase following stress 'let-down'
(Albert Einstein College of Medicine) Migraine sufferers who experienced reduced stress from one day to the next are at significantly increased risk of migraine onset on the subsequent day, according to a new study conducted by researchers at the Montefiore Headache Center and Albert Einstein College of Medicine at Yeshiva University. Stress has long been believed to be a common headache trigger. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 26, 2014 Category: Global & Universal Source Type: news

Body posture changes in women with migraine with or without temporomandibular disorders
Conclusion : The results demonstrated the presence of postural changes compared with a control group in women with migraines with or without TMD, and there were similar clinically relevant postural changes among the patients with migraines with and without TMD. Contextualização: Há relatos na literatura sobre associações entre migrânea e disfunção temporomandibular (DTM). Entretanto, não há relatos sobre a associação entre migrânea, DTM e alterações da postura corporal. Objetivos: Avaliar a presença de alterações da postura corporal em mulheres com migrânea com e sem DTM em relação a um grupo controle...
Source: Revista Brasileira de Fisioterapia - March 26, 2014 Category: Physiotherapy Source Type: research

Migraine predicts hypertension--a cohort study of the Finnish working-age population
Conclusion: The findings may indicate a focus on hypertension screening for the working-age population with migraine. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - March 26, 2014 Category: Journals (General) Authors: Entonen, A. H., Suominen, S. B., Korkeila, K., Mantyselka, P. T., Sillanmaki, L. H., Ojanlatva, A., Rautava, P. T., Koskenvuo, M. J. Tags: Cardiovascular disease Source Type: research

Innervation of Rat and Human Dura mater and Pericranial Tissues in the Parieto‐Temporal Region by Meningeal Afferents
ConclusionsWe conclude that a proportion of meningeal afferents innervates extracranial tissues like periosteum and pericranial muscles via collaterals projecting through the skull. These afferents may be nociceptive, some may subserve proprioceptive functions. The finding of extracranial projections of meningeal afferents may be important for our understanding of extracranial impacts on headache generation and therapy. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - March 26, 2014 Category: Neurology Authors: Markus Schueler, Winfried L. Neuhuber, Roberto De Col, Karl Messlinger Tags: Research Submission Source Type: research

Anafranil / Clomipramine Side Effects
Catalogue of side effects for the medication Anafranil - generic Clomipramine - an antidepressant used in the treatment of obsessive compulsive disorder, self-injury, panic attacks, phobias, depression, migraines and other comorbid symptoms of bipolar disorder. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - March 26, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

The TRPA1 Channel in Inflammatory and Neuropathic Pain and Migraine.
Abstract The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized to a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia. This subset of nociceptors produces and releases the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP), which mediate neurogenic inflammatory responses. TRPA1 is activated by a number of exogenous compounds, including molecules of botanical origin, environmental irritants, and medicines. However, the most prominent feature of TRPA1 resides in its unique sensitivity for ...
Source: Physiological Reviews - March 26, 2014 Category: Physiology Authors: Nassini R, Materazzi S, Benemei S, Geppetti P Tags: Rev Physiol Biochem Pharmacol Source Type: research

Large Conductance Calcium-Activated Potassium Channels: Their Expression and Modulation of Glutamate Release from Nerve Terminals Isolated from Rat Trigeminal Caudal Nucleus and Cerebral Cortex.
In this study, we analyzed the effects of BK channel activators and blockers on glutamate and γ-aminobutyric acid (GABA) release from synaptosomes isolated from the cerebral cortices or trigeminal caudal nuclei (TCN) of rats. Real-time polymerase chain reaction was used to characterize BK channel α and β(1-4) subunit expression in the cortex and in the trigeminal ganglia (TG), whose neurons project primary terminal afferents into the TCN. Immunocytochemistry was used to localize these subunits on cortical and TCN synaptosomes. The BK channels regulating [(3)H]D-aspartate release from primary afferent nerve terminals pro...
Source: Neurochemical Research - March 26, 2014 Category: Neuroscience Authors: Samengo I, Currò D, Barrese V, Taglialatela M, Martire M Tags: Neurochem Res Source Type: research

CGRP and VIP levels as predictors of efficacy of onabotulinumtoxin type A in chronic migraine.
CONCLUSIONS: Interictal CGRP and, to a lesser degree, VIP levels measured in peripheral blood are of great help on predicting response to onabotA. PMID: 24673487 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 26, 2014 Category: Neurology Authors: Cernuda-Morollón E, Martínez-Camblor P, Ramón C, Larrosa D, Serrano-Pertierra E, Pascual J Tags: Headache Source Type: research

Innervation of Rat and Human Dura mater and Pericranial Tissues in the Parieto-Temporal Region by Meningeal Afferents.
CONCLUSIONS: We conclude that a proportion of meningeal afferents innervates extracranial tissues like periosteum and pericranial muscles via collaterals projecting through the skull. These afferents may be nociceptive, some may subserve proprioceptive functions. The finding of extracranial projections of meningeal afferents may be important for our understanding of extracranial impacts on headache generation and therapy. PMID: 24673461 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - March 26, 2014 Category: Neurology Authors: Schueler M, Neuhuber WL, De Col R, Messlinger K Tags: Headache Source Type: research

Altered brainstem auditory evoked potentials in a rat central sensitization model are similar to those in migraine.
Abstract Migraine symptoms often include auditory discomfort. Nitroglycerin (NTG)-triggered central sensitization (CS) provides a rodent model of migraine, but auditory brainstem pathways have not yet been studied in this example. Our objective was to examine brainstem auditory evoked potentials (BAEPs) in rat CS as a measure of possible auditory abnormalities. We used four subdermal electrodes to record horizontal (h) and vertical (v) dipole channel BAEPs before and after injection of NTG or saline. We measured the peak latencies (PLs), interpeak latencies (IPLs), and amplitudes for detectable waveforms evoked by ...
Source: Brain Research - March 26, 2014 Category: Neurology Authors: Arakaki X, Galbraith G, Pikov V, Fonteh AN, Harrington MG Tags: Brain Res Source Type: research

In Ranchers Vs. Weeds, Climate Change Gives Weeds An Edge
Invasive weeds are already a big headache for ranchers, who spend thousands of dollars to get rid of them. New research shows that a changing climate is likely to help many of these weeds thrive.» E-Mail This (Source: NPR Health and Science)
Source: NPR Health and Science - March 25, 2014 Category: Consumer Health News Source Type: news

Elvis Presley could have died from underlying heart condition
After tracking down a sample of Elvis’ hair and analysing his DNA, scientists found that the singer was genetically prone to migraines, obesity and heart disease. (Source: the Mail online | Health)
Source: the Mail online | Health - March 25, 2014 Category: Consumer Health News Source Type: news

TENSION HEADACHE RELIEF (Acetaminophen, Caffeine) Capsule [GREENBRIER INTERNATIONAL, INC.]
Updated Date: Mar 25, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 25, 2014 Category: Drugs & Pharmacology Source Type: news

EXTRA STRENGTH HEADACHE RELIEF (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [GREENBRIER INTERNATIONAL, INC.]
Updated Date: Mar 25, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - March 25, 2014 Category: Drugs & Pharmacology Source Type: news