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Bitter lupine beans ingestion in a child: a disregarded cause of acute anticholinergic toxicity
Conclusion: Acute anticholinergic syndrome can arise after the consumption of a wide range of exogenous substances including partially debittered lupine beans. Paediatricians should be aware of bitter lupine toxicity, recognize possible cases of intoxication, ensure a prompt and appropriate supportive treatment and provide appropriate information about their danger. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - November 27, 2014 Category: Pediatrics Source Type: research

A New Mechanism for Migraine PreventionA New Mechanism for Migraine Prevention
Two studies using monoclonal antibodies to target the calcitonin gene-related peptide could offer a novel way to prevent migraine. Medscape Neurology (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - November 27, 2014 Category: Neurology Tags: Neurology & Neurosurgery Commentary Source Type: news

Meditation for Migraines: A Pilot RCTMeditation for Migraines: A Pilot RCT
Can a mindfulness-based stress reduction course based on meditation and yoga be a beneficial intervention for patients with migraine? Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 27, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Peripheral nerve blocks in the treatment of migraine in pregnancy.
CONCLUSION: Peripheral nerve blocks for treatment-refractory migraine may be an effective therapeutic option in pregnancy. LEVEL OF EVIDENCE: : III. PMID: 25415168 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - November 27, 2014 Category: OBGYN Authors: Govindappagari S, Grossman TB, Dayal AK, Grosberg BM, Vollbracht S, Robbins MS Tags: Obstet Gynecol Source Type: research

The effect of serial in vitro haemodilution with maternal cerebrospinal fluid and crystalloid on thromboelastographic (TEG®) blood coagulation parameters, and the implications for epidural blood patching
Summary Epidural blood patches may be used to treat post‐dural puncture headache following accidental dural puncture in parturients. Their mode of action and the optimum volume of blood for injection remain controversial, with the interaction between injected blood and cerebrospinal fluid unknown. We aimed to establish the effects of serial haemodilution of whole blood with cerebrospinal fluid from 34 pregnant patients compared with serial haemodilution with Hartmann's solution, using the thromboelastogram. Haemodilution with either cerebrospinal fluid or Hartmann's solution had significant procoagulant and clot destabil...
Source: Anaesthesia - November 27, 2014 Category: Anesthesiology Authors: S. Armstrong, R. Fernando, P. Tamilselvan, A. Stewart, M. Columb Tags: Original Article Source Type: research

Men don't get headache – do they?
The majority of troublesome headaches will be migraine, which is not difficult to diagnose and there are a number of effective treatment options. Although migraine headaches are more common in women, a significant number of men do experience them, but men are less likely to seek help from their GP. (Source: Trends in Urology, Gynaecology and Sexual Health)
Source: Trends in Urology, Gynaecology and Sexual Health - November 27, 2014 Category: OBGYN Authors: David Kernick Tags: Men's Health Source Type: research

Avanir to Provide More Human-Factor Data for Migraine Treatment
Avanir Pharmaceuticals, which previously said the FDA had questions about “human factor” study data for a migraine treatment, said it will provide new data. (Source: WSJ.com: Health)
Source: WSJ.com: Health - November 26, 2014 Category: Pharmaceuticals Tags: PAID Source Type: news

FDA rejects Avanir's migraine drug-device
(Reuters) - The U.S. Food and Drug Administration rejected Avanir Pharmaceuticals Inc's migraine drug device, a few weeks after the regulator had raised questions regarding some data submitted as part of the marketing application. (Source: Reuters: Health)
Source: Reuters: Health - November 26, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

Bevacizumab Receives New Labeled Indication
* Bevacizumab (Avastin) is now approved to treat persistent, recurrent, or metastatic cervical cancer when given with one of two other approved drug therapies, paclitaxel and cisplatin or paclitaxel and topotecan. * The most common adverse effects noted in the phase 3 study of bevacizumab used to treat ovarian cancer were fatigue, decreased appetite, hypertension, hyperglycemia, hypomagnesemia, urinary tract infection, headache, and weight loss. Severe adverse effects are possible. (Source: AJN)
Source: AJN - November 26, 2014 Category: Nursing Tags: Drug Watch Source Type: research

A Severe Case of Lemierre Syndrome with Streptococcus constellatus Infection.
Abstract A 76-year-old Japanese male presenting with high fever, headache, and disturbance of consciousness was hospitalized. Contrast computed tomography revealed thrombophlebitis in the internal jugular vein and abscesses in the posterior neck region, pharynx, and pterygoid muscle. Streptococcus constellatus infection was confirmed by culture of blood samples, and the patient was diagnosed with Lemierre syndrome. In addition to the administration of antibiotics and anticoagulants, abscess drainage was performed. S. constellatus should be considered as a causative bacterium in elderly patients with Lemierre syndro...
Source: Japanese Journal of Infectious Diseases - November 26, 2014 Category: Infectious Diseases Authors: Shimada M, Morinaga Y, Kitazaki T, Fukuda M, Hashiguchi K, Yanagihara K, Kohno S Tags: Jpn J Infect Dis Source Type: research

Stroke as the First Clinical Manifestation of Takayasu's Arteritis
In conclusion, Takayasu's arteritis must be recognized as a potential cause of ischemic stroke in young females.Case Rep Neurol 2014;6:271-274 (Source: Case Reports in Neurology)
Source: Case Reports in Neurology - November 26, 2014 Category: Neurology Source Type: research

Assessment of atrial electromechanical delay in patients with migraine
Abstract Evidence suggests that symptoms of migraine are related to the involvement of the autonomic nervous system. Data on atrial conduction system are limited in migraineurs. We aimed to assess atrial electromechanical delay using tissue Doppler imaging (TDI) in patients with migraine. Forty-five migraine patients and age- and sex-matched 26 control subjects were enrolled in the study. All the patients and controls underwent resting surface electrocardiogram (ECG) and TDI. The maximum P-wave duration (Pmax), minimum P-wave duration (Pmin) and P-wave dispersion (Pd) were measured from the 12-lead ECG. Atrial co...
Source: Acta Neurologica Belgica - November 26, 2014 Category: Neurology Source Type: research

Delayed diagnosis of subacute angle closure glaucoma in patients presenting with headaches
This study characterizes the medical course and symptoms of patients with SACG in whom headache was the major symptom. This retrospective observational study consisted of 30 consecutive patients, suffering from headaches and diagnosed with SACG, collected from the Glaucoma Service at the Ophthalmology Department of Meir Medical Center, Kfar Saba, Israel, a tertiary care referral facility. The primary study outcomes were reasons for referral, number of specialists visited and number of imaging studies performed before diagnosing SACG and headache characteristics. The majority of the patients experienced headaches once or tw...
Source: Acta Neurologica Belgica - November 26, 2014 Category: Neurology Source Type: research

Another Step Forward for Migraine BiomarkerAnother Step Forward for Migraine Biomarker
A new study has found that levels of adiponectin, an adipose cytokine, are higher in older people with migraine, particularly men. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - November 26, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts
Publication date: May 2014 Source:Molecular Genetics and Metabolism, Volume 112, Issue 1 Author(s): Kamil S. Sitarz , Hannah R. Elliott , Betül S. Karaman , Caroline Relton , Patrick F. Chinnery , Rita Horvath Valproic acid (VPA) is a widely used antiepileptic drug and also prescribed to treat migraine, chronic headache and bipolar disorder. Although it is usually well tolerated, a severe hepatotoxic reaction has been repeatedly reported after VPA administration. A profound toxic reaction on administration of VPA has been observed in several patients carrying POLG mutations, and heterozygous genetic variation in POLG ha...
Source: Molecular Genetics and Metabolism - November 26, 2014 Category: Genetics & Stem Cells Source Type: research

Antiphospholipid syndrome: an important differential diagnosis for culture-negative endocarditis
Sometimes the initial diagnosis proves secondary to an illness that is diagnosed later. This was the case when a 37-year-old woman presented to the hospital with sudden-onset persistent left-sided weakness. While she reported pain in the right maxilla, lethargy, and malaise in the month prior to presentation, she denied headache, sensory change, visual disturbances, fever, chills or weight loss. Hypertension was her only cardiovascular risk factor, but she took no regular medications. She had no history of stroke, ischemic heart disease, deep vein thrombosis, pulmonary embolism, or miscarriage, and she had no family histor...
Source: The American Journal of Medicine - November 26, 2014 Category: Journals (General) Authors: Louis W. Wang, Baptiste Noël, Elodie Descloux, David W. Baron Source Type: research

Pulsed radiofrequency for occipital neuralgia.
CONCLUSION: Clinical studies to date examining the efficacy of PRF as a treatment for occipital neuralgia have yielded promising results, demonstrating sustained improvement in pain, quality of life, and adjuvant pain medication usage. Despite these encouraging clinical studies, conclusive evidence in support of PRF as an interventional treatment option for occipital neuralgia awaits to be seen. PMID: 25415786 [PubMed - in process] (Source: Pain Physician)
Source: Pain Physician - November 25, 2014 Category: Anesthesiology Authors: Manolitsis N, Elahi F Tags: Pain Physician Source Type: research

Tryptamine levels are low in plasma of chronic migraine and chronic tension-type headache
Abstract The primary aim of this study (TA-CH, Tryptophan Amine in Chronic Headache) was to investigate a possible role of tryptophan (TRP) metabolism in chronic migraine (CM) and chronic tension-type headache (CTTH). It is not known if TRP metabolism plays any role in CM and/or CTTH. Plasma levels of serotonin (5-HT), 5-hydroxyindolacetic acid (5-HIAA), metabolite of 5-HT, and tryptamine (TRY) were tested in 73 patients with CM, 15 patients with CTTH and 37 control subjects. Of these, plasmatic TRY was significantly lower in CM (p < 0.001) and in CTTH (p < 0.002) patients with respect to control subjec...
Source: Neurological Sciences - November 25, 2014 Category: Neurology Source Type: research

Decreased antioxidant status in migraine patients with brain white matter hyperintensities
Abstract Migraine patients have an increased risk to develop deep white matter hyperintensities (WMH) than the general population. Oxidative stress is believed to play a role in the pathogenesis of migraine. The present study was undertaken to assess oxidant/antioxidant balance of migraineurs with and without WMH. We hypothesized that increased oxidative stress and decreased antioxidant response may play a role in the pathophysiology of WMH in migraineurs. The study included 32 patients in the migraine group and 17 age- and sex-matched healthy subjects without headache in the control group. The migraine group com...
Source: Neurological Sciences - November 25, 2014 Category: Neurology Source Type: research

Are atraumatic spinal needles as efficient as traumatic needles for lumbar puncture?
Abstract The most frequent complication of lumbar puncture is post lumbar puncture headache (PLPH). Recent studies confirmed that the use of atraumatic spinal needles significantly reduces the risk of PLPH. However, the majority of neurologists still use traumatic needles, possibly caused by misconceptions and beliefs about practical performance of atraumatic spinal needles. Therefore, we investigated the practical characteristics of atraumatic and traumatic spinal needles. An experimental setup with a fluid column was used with (1) a physiological NaCl 0.9 % solution and (2) a high protein content solution. Flo...
Source: Neurological Sciences - November 25, 2014 Category: Neurology Source Type: research

HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009: A Retrospective Study.
Conclusions. HIV-associated CNS disease is common in Douala. CNS symptoms in HIV patients need urgent investigation because of their association with diseases of high case fatality. PMID: 23533732 [PubMed] (Source: AIDS Research and Treatment)
Source: AIDS Research and Treatment - November 25, 2014 Category: Infectious Diseases Tags: AIDS Res Treat Source Type: research

Ectopic presence of tooth within the mandibular condyle.
This article describes the case of a 41-year-old woman who presented with the complaint of crepitation sound and mild pain in the left temporomandibular joint area. Panoramic radiographs taken to rule out degenerative or arthritic changes in the joints demonstrated a radiopaque mass within the left condyle. Cone beam computed tomography scans revealed an ectopic tooth located centrally within the left condyle. Thus, while considered rare, the mandibular condyle can be a possible location of an ectopic tooth. PMID: 25347172 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Pregabalin reduces acute inflammatory and persistent pain associated with nerve injury and cancer in rat models of orofacial pain.
CONCLUSION: Pregabalin produced a marked antinociceptive effect in rat models of facial inflammatory pain as well as in facial neuropathic and cancer pain models, suggesting that it may represent an important agent for the clinical control of orofacial pain. PMID: 25347171 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Orofacial pain of muscular origin is not associated with herpes virus-6 infection: a pilot study.
CONCLUSION: The results of this pilot study indicate that HHV-6 infection or reactivation does not appear to play a role in the pathogenesis of TMD reflecting a localized myalgia. PMID: 25347170 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

The association between temporomandibular disorders and suicide ideation in a representative sample of the South korean population.
CONCLUSION: Pain conditions, including TMD pain, might aggravate SI among those with a cancer history. These findings add to a growing body of evidence indicating that TMD warrants further attention in relation to suicide. PMID: 25347169 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Bony deviations revealed by cone beam computed tomography of the temporomandibular joint in subjects without ongoing pain.
CONCLUSION: CBCT images of asymptomatic adult TMJs commonly show degenerative bony alterations. Accordingly, such radiographic findings should be used with care and only as a supplement to clinical assessment. PMID: 25347168 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Temporomandibular Disorder Pain Is Related to the General Disposition to be Anxious.
CONCLUSION: Trait anxiety is significantly associated with diagnoses of TMD pain. PMID: 25347167 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Craniofacial pain of cardiac origin is associated with inferior wall ischemia.
CONCLUSION: The occurrence of craniofacial pain during myocardial ischemia, with or without an acute myocardial infarction, was associated with ischemia within the inferior wall. This result suggests the involvement of the vagal afferent system in the mechanisms of craniofacial pain of cardiac origin. PMID: 25347166 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Quantitative sensory testing in patients with or without ongoing pain one year after orthognathic surgery.
CONCLUSION: The pattern of sensory alteration in orthognathic surgical patients with or without pain was characterized by sensory loss in thermal parameters and non-nociceptive mechanosensory parameters and sensory gain in nociceptive mechanosensory parameters. The elevated VDT might be a potential indicator of the impact of postoperative pain on trigeminal somatosensory functions. PMID: 25347165 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Sleep bruxism and sleep-disordered breathing: a systematic review.
CONCLUSION: There is not sufficient scientific evidence either to confirm or discredit the association between SB and SDB. PMID: 25347164 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Periorbital pain induced by the concha bullosa fungus ball: a case report.
This article describes a patient with such a fungus ball in the concha bullosa that caused right periorbital pain, specifically in the right medial canthal area, similar to mucosal contact point headache. PMID: 25068222 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effects of chemically induced hypoxia on in vitro expression of hypoxia inducible factor-lα, vascular endothelial growth factor, aggrecanase-1, and tissue inhibitor of metalloproteinase-3 in rat mandibular condylar chondrocytes.
CONCLUSION: An upregulated HIF-1α and VEGF mRNA expression indicates their important roles in cartilage vascularization and development in newly hypoxic microenvironments. Additionally, chemically induced hypoxia has little effect on the expressions of ADAMTS-4 and TIMP-3. PMID: 25068221 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effects of low-intensity pulsed ultrasound on the expression of cyclooxygenase-2 in mandibular condylar chondrocytes.
CONCLUSION: LIPUS exposure inhibited IL-1β-induced COX-2 expression through the integrin β1 receptor followed by the phosphorylation of ERK 1/2. Despite the restricted duration of its effect, LIPUS is suggested to be a potential candidate as a preventive and auxiliary treatment to suppress the degradation of articular chondrocytes in temporomandibular joint osteoarthritis. PMID: 25068220 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effects of muscle pain induced by glutamate injections during sustained clenching on the contraction pattern of masticatory muscles.
CONCLUSION: Intramuscular injection of glutamate caused more pain than isotonic saline but did not affect the contraction pattern of the masticatory muscles during a sustained clenching task. This finding strongly suggests the adaptive capacity of the stomatognathic system in the presence of acute nociceptive inputs. PMID: 25068219 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

"Grin(d) and bear it": narratives from Sami women with and without temporomandibular disorders. A qualitative study.
CONCLUSION: Based on the analysis, the following hypothesis was generated: Women with TMD, associated headaches, and neck-shoulder pain may benefit from efforts aimed at empowering them to use their own abilities to reduce stress behavior, strain, and disuse of the jaw. Rehabilitation strategies in groups might increase their sense of coherence and increase social support, which seems to be more limited than in women with no symptoms of TMD. PMID: 25068218 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

A comparative analysis of magnetic resonance imaging and radiographic examinations of patients with atypical odontalgia.
CONCLUSION: MRI examination revealed no changes in the painful region in a majority of patients with AO, suggesting that inflammation was not present. MRI findings were significantly correlated to radiographic findings. PMID: 25068217 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Beliefs and distress about orofacial pain: patient journey through a specialist pain consultation.
CONCLUSION: Patients' fears and beliefs about chronic orofacial pain are dominated by worrying and searching for meaning before consultation. Information about their chronic pain condition counters feelings of helplessness and supports sense-making around pain when explanations are clear, are delivered sensitively from a trusted source, and take into account the patient's existing health beliefs; this promotes self-management. These findings underline the important functions of specialist consultation in achieving a shared accurate understanding of pain and options for treatment. PMID: 25068216 [PubMed - indexed for ME...
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

A systematic review and meta-analysis of usual treatment versus psychosocial interventions in the treatment of myofascial temporomandibular disorder pain.
CONCLUSION: No evidence was found to distinguish the clinical effectiveness between "usual treatment" and psychosocial interventions for myofascial TMD pain. Future studies of TMD and related subdiagnoses should be reported according to core standardized outcomes to facilitate comparisons. PMID: 25068215 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Experimental jaw muscle pain increases pain scores and jaw movement variability in higher pain catastrophizers.
CONCLUSION: The increased reported pain intensity, pain areas, and pain rating indices are consistent with enhanced central sensitization processes in high-catastrophizing individuals. The slower velocity and greater variability of repetitive jaw movements in higher pain catastrophizing individuals in acute experimental pain may reflect changes in motor coordination as an example of avoidance behavior for the jaw motor system. PMID: 25068214 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Opioid drug addiction and pain: diagnostic and management challenges.
Authors: Sessle BJ PMID: 25068213 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Masticatory and cervical muscle tenderness and pain sensitivity in a remote area in subjects with a temporomandibular disorder and neck disability.
CONCLUSION: The results of this study have highlighted the importance of assessing TMD patients not only in the craniofacial region but also in the neck and other parts of the body. Future studies should focus on testing the effectiveness of treatments addressing the neck and the pain sensitivity in the hand in patients with TMD. PMID: 24829929 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Bilateral stellate ganglion blockade for recalcitrant oral pain from Burning Mouth Syndrome: a case report.
This article presents a case report of stellate ganglion blockade as a treatment for recalcitrant pain from BMS. PMID: 24822241 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Tuberculosis of the temporomandibular joint: a case of misdiagnosis.
This article describes an unusual case of a 53-year-old man with painful swelling in the right preauricular area accompanied by difficulty in mouth opening. After surgical exploration, histopathologic findings revealed TB in the TMJ. The findings of this case highlight the importance of considering TB in the differential diagnosis of TMJ pain, especially for patients from endemic areas, patients who have lived or visited those areas, or patients with a preauricular swelling in the TMJ area. PMID: 24822240 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effect of experimental tooth clenching on the release of β-endorphin.
CONCLUSION: This experimental tooth-clenching task was not associated with significant alterations in β-endorphin levels over time, but with mechanical hyperalgesia and low to moderate levels of pain in healthy subjects and M-TMD patients, respectively. More research is required to understand the role of the β-endorphinergic system in the etiology of M-TMD. PMID: 24822239 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Ketoprofen is more effective than diclofenac after oral surgery when used as a preemptive analgesic: a pilot study.
CONCLUSION: Intramuscular ketoprofen 100 mg is more effective than intramuscular diclofenac 75 mg after mandibular third molar extraction when used as a preemptive analgesic. PMID: 24822238 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Epidemiology of severity of temporomandibular disorders in Brazilian women.
CONCLUSION: The severity of TMD among Brazilian women was greater in nonusers of dental prostheses and was also associated with greater mandibular functional limitation and poor perception of oral health. PMID: 24822237 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effectiveness of a prefabricated occlusal appliance in patients with temporomandibular joint pain: a randomized controlled multicenter study.
CONCLUSION: The effectiveness of the prefabricated appliance seems to be similar to that of the stabilization appliance in alleviating TMJ pain. Since the prefabricated appliance requires only one visit for construction, it is convenient for both the general practitioner and for the patient. PMID: 24822236 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
CONCLUSION: The use of tizanidine or cyclobenzaprine in addition to self-care management and patient education was not more effective than placebo for the management of patients with myofascial jaw pain upon awakening. PMID: 24822235 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Topical review: the enigma of fibromyalgia.
This article reviews the epidemiology, etiology, pathophysiology, and clinical presentation of fibromyalgia, as well as therapeutic advances. Also highlighted are issues that are important to the oral health care provider, including orofacial manifestations and oral health care considerations for patients with fibromyalgia. PMID: 24822234 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

The next frontier: digital disease detection in cyberspace.
Authors: Stohler C PMID: 24822233 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research