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Rate of Ascent and Acute Mountain Sickness at High Altitude
Conclusions: The development of AMS was closely associated with an initial reduction in SaO2. A BMI >24 kg/m2 also contributed to the occurrence of AMS. Clinical Relevance: These findings indicate that factors other than ascent rate should be considered when trying to ameliorate the risk of AMS. (Source: Clinical Journal of Sport Medicine)
Source: Clinical Journal of Sport Medicine - March 1, 2015 Category: Sports Medicine Tags: Original Research Source Type: research

Pituitary Apoplexy
Pituitary apoplexy (PA) is a rare clinical syndrome caused by sudden hemorrhaging and/or infarction of the pituitary gland, generally within a pituitary adenoma. The main symptom is sudden-onset severe headache, associated with visual disorders or ocular palsy. Corticotropic deficiency may be life-threatening if left untreated. Computed tomography (CT) or MRI confirms the diagnosis by revealing a pituitary tumor with hemorrhagic and/or necrotic components. PA used to be considered a neurosurgical emergency but a conservative approach is increasingly used in selected patients, as it yields similar outcomes. Glucocorticoid t...
Source: Endocrinology and Metabolism Clinics of North America - March 1, 2015 Category: Endocrinology Authors: Claire Briet, Sylvie Salenave, Philippe Chanson Source Type: research

Hydrogen Sulfide Suicide: A New Trend and Threat to Healthcare Providers
First popularized in Japan, hydrogen sulfide (H2S) gas suicide is an underreported form of suicide with known risk for secondary disaster. Mortality rate commonly exceeds 90% because of the gas’s lethal, noncontained nature. Instances in the United States are increasing, up from 2 cases in 2008 to 18 in 2010. Because H2S poisonings remain rare, there exists a lack of knowledge regarding the residual effects of gas venting after victim extrication. Identifying instances of the efficacious use of personal protection equipment (PPE) is critical in the effort to alleviate risks faced by hospital and rescue personnel. The cur...
Source: Journal of Burn Care and Research - February 28, 2015 Category: Rehabilitation Tags: Original Articles Source Type: research

Are cannabinoids effective for orofacial pain states?
Authors: Sessle BJ PMID: 25715439 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - February 28, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Effects of Ethanol on the Pharmacokinetics of Extended-Release Oxycodone with Sequestered Naltrexone (ALO-02)
Conclusions Oxycodone exposures (C max) were unaffected when ALO-02 was administered with 20 % ethanol but C max increased by 37 % with 40 % ethanol versus water. ALO-02 administered with ethanol under naltrexone block was generally well tolerated. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 28, 2015 Category: Drugs & Pharmacology Source Type: research

Headache
Publication date: 28 February–6 March 2015 Source:The Lancet, Volume 385, Issue 9970 Author(s): Nicholas F Brown , Saurabh Jain , Stephen B Walsh , Jeremy Gibbs , Aroon Hingorani (Source: The Lancet)
Source: The Lancet - February 28, 2015 Category: Journals (General) Source Type: research

Oral Contraception
Oral contraception (OC) remains a popular noninvasive, readily reversible approach for pregnancy prevention and, largely off label, for control of acne, hirsutism, dysmenorrhea, irregular menstruation, menorrhagia, and other menstrual-related symptoms. Many OC formulations exist, with generics offering lower cost and comparable efficacy. Certain medical conditions, including hypertension, migraine, breast cancer, and risk of venous thromboembolism (VTE), present contraindications. Blood pressure measurement is the only physical examination or testing needed before prescription. Although no OC is clearly superior to others,...
Source: Medical Clinics of North America - February 28, 2015 Category: Primary Care Authors: Ginger Evans, Eliza L. Sutton Source Type: research

Peri-incisional botulinum toxin for chronic post craniotomy headache following traumatic brain injury: A case series
Botulinum neurotoxin (BoNT) has been successfully used to treat primary headache syndromes but there is no published data on its use for chronic post craniotomy headache. BoNT-A (4:1 dilution) was injected at a dose of 15-50 units into peri-incisional sites of the scalp in three patients who had remotely undergone craniotomy for traumatic epidural hematoma. All patients reported reductions in headache lasting at least 2.5 months. Repeat injections were performed in all cases with favourable outcomes. (Source: PM and R)
Source: PM and R - February 28, 2015 Category: Rehabilitation Authors: Heather M. MacKenzie, Robert Teasell, Thomas Miller, Keith Sequeira Source Type: research

Human Infections with Sarcocystis Species.
Abstract SUMMARY: Recurrent outbreaks of muscular sarcocystosis among tourists visiting islands in Malaysia have focused international attention on sarcocystosis, a disease once considered rare in humans. Sarcocystis species require two hosts, definitive and intermediate, to complete their life cycle. Humans can serve as definitive hosts, with intestinal sarcocystosis for two species acquired from eating undercooked meat: Sarcocystis hominis, from beef, and Sarcocystis suihominis, from pork. Symptoms such as nausea, stomachache, and diarrhea vary widely depending on the number of cysts ingested but appear more seve...
Source: Clinical Microbiology Reviews - February 27, 2015 Category: Microbiology Authors: Fayer R, Esposito DH, Dubey JP Tags: Clin Microbiol Rev Source Type: research

[Morning Report] Headache
A 53-year-old man presents with headache and hypertension. How would you differentiate intrinsic renal disease from renal end-organ damage? How would you lower his blood pressure safely, to what target, and with which agent? What is your response when he asks whether his clinical features will improve? Test your knowledge in this Morning Report collaboration from The Lancet and the Royal Free Hospital. (Source: LANCET)
Source: LANCET - February 27, 2015 Category: Journals (General) Authors: Nicholas F Brown, Saurabh Jain, Stephen B Walsh, Jeremy Gibbs, Aroon Hingorani Tags: Morning Report Source Type: research

A Case of Cryptococcus gattii in Western Florida: An Aggressive Pathogen in an Immunocompetent Host
Conclusions: This is a virulent VGI strain of C. gattii, causing infection in an immunocompetent host in Western Florida with no recent travel history. Here, we discuss clinical, laboratory, diagnostic, and pathologic findings of the clinical presentation and its delayed diagnostic appearance in a nonendemic area. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - February 27, 2015 Category: Infectious Diseases Tags: Case Reports Source Type: research

Scrub Typhus in Hospitalized Children: A Missed Entity?
Conclusions: Scrub typhus in children should be considered in all hospitalized children, especially if there is a recent rural or outdoor exposure, an eschar, splenomegaly, or thrombocytopenia. Unlike adults, renal dysfunction and central nervous system involvement seem to be uncommon. All children recovered after treatment with azithromycin, doxycycline, or the combination. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - February 27, 2015 Category: Infectious Diseases Tags: Original Articles Source Type: research

Interplay between the Virus and Host in Rift Valley Fever Pathogenesis
Rift Valley fever virus (RVFV) belongs to the genus Phlebovirus, family Bunyaviridae, and carries single-stranded tripartite RNA segments. The virus is transmitted by mosquitoes and has caused large outbreaks among ruminants and humans in sub-Saharan African and Middle East countries. The disease is characterized by a sudden onset of fever, headache, muscle pain, joint pain, photophobia, and weakness. In most cases, patients recover from the disease after a period of weeks, but some also develop retinal or macular changes, which result in vision impairment that lasts for an undefined period of time, and severe disease, cha...
Source: Journal of Innate Immunity - February 27, 2015 Category: Allergy & Immunology Source Type: research

Acknowledgements to Referees
The quality of The Journal of Headache and Pain depends on the qualified and regular collaboration of renowned scientists, who devoted their time to constructively review the submitted articles.We are indebted to the following experts who reviewed papers that completed the peer-reviewing process within 2014. (Source: BioMed Central)
Source: BioMed Central - February 27, 2015 Category: Journals (General) Authors: Valerio De Angelis Source Type: research

Targeting the Serotonin 5-HT 7 Receptor in the Search for Treatments for CNS Disorders: Rationale and Progress to Date
Abstract The 5-HT7 (5-hydroxytryptamine 7, serotonin 7) receptor is one of the most recently identified members of the serotonin receptor family. Pharmacological tools, including selective antagonists and, more recently, agonists, along with 5-HT7 receptor (5-HT7R) knock-out mice have revealed the involvement of this receptor in central nervous system processes. Its well-established role in controlling body temperature and regulating sleep and circadian rhythms has implicated this receptor in mood disorders. Thus, the 5-HT7R has gained much attention as a possible target for the treatment of depression. Although p...
Source: CNS Drugs - February 27, 2015 Category: Neurology Source Type: research

Update and Mutational Analysis of SLC20A2: A Major Cause of Primary Familial Brain Calcification
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - February 27, 2015 Category: Genetics & Stem Cells Authors: Roberta R. Lemos, Marisa E. Ramos, Andrea Legati, Gaël Nicolas, Emma M. Jenkinson, John H. Livingston, Yanick J. Crow, Dominique Campion, Giovanni Coppola, João R.M. Oliveira Tags: Mutation Update Source Type: research

Intrasellar Symptomatic Salivary Gland Rest with Inflammations
Conclusions Not only are instances of symptomatic ectopic salivary glands rare, but this was also the first case detected to be caused by the pathophysiology involving the leakage of secretions from an ectopic salivary gland and associated inflammation. We report this case to help elucidate the pathophysiology of the condition. (Source: World Neurosurgery)
Source: World Neurosurgery - February 27, 2015 Category: Neurosurgery Source Type: research

Randomized phase III trial of prophylactic cranial irradiation versus observation in patients with fully resected stage IIIA-N2 nonsmall-cell lung cancer and high risk of cerebral metastases after adjuvant chemotherapy
Conclusion In patients with fully resected postoperative pathologically confirmed stage IIIA–N2 NSCLC and high risk of cerebral metastases after adjuvant chemotherapy, PCI prolongs DFS and decreases the incidence of brain metastases. (Source: Annals of Oncology)
Source: Annals of Oncology - February 27, 2015 Category: Cancer & Oncology Authors: Li, N., Zeng, Z.- F., Wang, S.- Y., Ou, W., Ye, X., Li, J., He, X.- H., Zhang, B.- B., Yang, H., Sun, H.- B., Fang, Q., Wang, B.- X. Tags: thoracic tumors Source Type: research

Osler on Migraine.
The objectives of this study were to review Osler's thoughts on migraine, and outline his therapeutic recommendations. Preventively Osler mentioned bromides, iron, arsenic, nitroglycerin, and cannabis. Acutely he recommended coffee, chloroform, cannabis, antipyrin, antifebrin, phenacetin, caffeine citrate, nux vomica, or ergot. He thought cannabis was the most satisfactory remedy. Osler was not a therapeutic nihilist when it came to migraine, and his treatment recommendations were similar to other writers of his time. Osler did not draw upon his personal experience to contribute new knowledge about migraine. Regardless, gi...
Source: The Canadian Journal of Neurological Sciences - February 27, 2015 Category: Neurology Authors: Boes CJ Tags: Can J Neurol Sci Source Type: research

Topographic Analysis of Electroencephalographic Changes during Photic Driving Responses in Patients with Migraine
Conclusion: Photic hypersensitivity and photic driving responses were increased in migraineurs. Photic hypersensitivity might result in sensitization of the limbic system.Neuropsychobiology 2015;71:49-62 (Source: Neuropsychobiology)
Source: Neuropsychobiology - February 26, 2015 Category: Psychiatry & Psychology Source Type: research

Top Georgia Pain Centers, Spine Care & Pain Management, Now...
The top pain centers in Georgia, Spine Care & Pain Management, is now offering Botox injections for migraine relief. The outpatient procedure is typically able to decrease both the frequency and...(PRWeb February 25, 2015)Read the full story at http://www.prweb.com/releases/atlantapainmanagement/botoxinjectionsmigraines/prweb12542479.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 26, 2015 Category: Pharmaceuticals Source Type: news

Evidence of Multidomain Mild Cognitive Impairment in Idiopathic Intracranial Hypertension
Conclusions: Our results indicate that patients with IIH have mild cognitive impairment. All domain measures apart from memory showed a statistically significant difference from normal individuals, indicating that there is a form of multidomain cognitive impairment in IIH. The relationship between cognitive impairment and chronically elevated intracranial pressures and its role in contributing to patient morbidity requires further study. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Original Contribution Source Type: research

Association of cinnarizine and betahistine in prophylactic therapy for Ménière's disease with and without migraine.
Authors: Teggi R, Gatti O, Sykopetrites V, Quaglieri S, Benazzo M, Bussi M Abstract Prophylactic therapy of Ménière's disease (MD) includes betahistine and calcium-blockers (the latter also useful for migraine prevention). The aim of our work was to assess the efficacy of combined therapy with cinnarizine and betahistine in MD subjects both with and without migraine and poorly responsive to betahistine alone. Fifty-two MD subjects were included who were poorly responsive to betahistine during 6 months of follow-up; 29 were migraineurs. Combined therapy was administered with betahistine 48 mg/day and cinnarizine 2...
Source: Acta Otorhinolaryngologica Italica - February 26, 2015 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Mucosal contact points and paranasal sinus pneumatization: Does radiology predict headache causality?
ConclusionsRadiological identification of MCP, CB, or hyperpneumatized sinuses does not seem to be a predictor of headache causality. Further studies are required to identify clinical scenarios in which these variations may contribute to pain symptoms. Level of Evidence3b. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - February 26, 2015 Category: ENT & OMF Authors: Islam R. Herzallah, Maged A. Hamed, Salem M. Salem, Maria V. Suurna Tags: Allergy/Rhinology Source Type: research

HEADACHE PM (Acetaminophen, Diphenhydramine Hcl) Tablet, Film Coated [HyVee Inc]
Updated Date: Feb 26, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 26, 2015 Category: Drugs & Pharmacology Source Type: news

The problem of unrecognized acromegaly: surgeries patients undergo prior to diagnosis of acromegaly
Conclusions Acromegaly patients mostly present to internal medicine professionals. Surgeries related to acromegaly complications and symptoms before diagnosis cause a long delay period before diagnosis. Medical staff must be more aware of the clinical aspects of acromegaly. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 26, 2015 Category: Endocrinology Source Type: research

Assessment of the CROS (Contralateral Routing of Signal) system in unilateral cochlear implantation
ConclusionCROS‐CI is an interesting novel option, restoring a binaural effect and providing improved speech perception and non‐negligible comfort of hearing in certain patients, without the medical and economic costs of bilateral CI. However, the drawbacks (especially the difficulty of modulating the signal‐to‐noise ratio) do not presently allow it to be an effective alternative to bilateral CI.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - February 26, 2015 Category: ENT & OMF Authors: Nicolas Guevara, Claire Grech, Ivan Gahide, Stéphane Gallego Tags: Original Article Source Type: research

On-field management and return-to-play in sports-related concussion in children: Are children managed appropriately?
Conclusions Many children with sports related-concussion are not formally assessed on-field and continue to play. On-field concussion management and return to play practices are often suboptimal. Awareness and education of coaches, teachers, parents and children need to be improved. (Source: Journal of Science and Medicine in Sport)
Source: Journal of Science and Medicine in Sport - February 26, 2015 Category: Sports Medicine Source Type: research

Efficacy and safety of acetylcysteine in “non-acetaminophen” acute liver failure: A meta-analysis of prospective clinical trials
Conclusion NAC is safe for NAI-ALF. It can prolong patients’ survival with native liver without transplantation and survival after transplantation, but it cannot improve the overall survival. (Source: Clinics and Research in Hepatology and Gastroenterology)
Source: Clinics and Research in Hepatology and Gastroenterology - February 26, 2015 Category: Gastroenterology Source Type: research

Persistent vertigo and dizziness after mild traumatic brain injury
Vertigo, dizziness, and disequilibrium are common symptoms following concussion or mild traumatic brain injury (mTBI). Dizziness and vertigo may be the result of trauma to the peripheral vestibular system or the central nervous system, or, in some cases, may be due to anxiety, depression, or posttraumatic stress disorder; these mechanisms are not mutually exclusive. While most peripheral vestibular disorders can be identified by testing and examination, those without inner‐ear causes that have persisting complaints of dizziness and motion sickness are more difficult to understand and to manage. Some of these patients exh...
Source: Annals of the New York Academy of Sciences - February 26, 2015 Category: Science Authors: Terry D. Fife, Deepak Kalra Tags: Original Article Source Type: research

Vestibular migraine
This article will discuss the demographics, epidemiology, clinical manifestations, physical examination findings, laboratory testing, comorbidities, treatment options, and pathophysiology of vestibular migraine. Future research in the field of vestibular migraine should include both clinical and basic science efforts to better understand the pathophysiology of this condition. Controlled treatment trials for vestibular migraine are desperately needed. (Source: Annals of the New York Academy of Sciences)
Source: Annals of the New York Academy of Sciences - February 26, 2015 Category: Science Authors: Joseph M. Furman, Carey D. Balaban Tags: Original Article Source Type: research

Boy allergic to SUN is determined to become a professional golfer
Ben Brown, from Stockton, breaks out in hives and a rash, as well as developing migraines if he goes out in the sun. He takes antihistamine tablets, migraine tablets and has prescription suncream. (Source: the Mail online | Health)
Source: the Mail online | Health - February 25, 2015 Category: Consumer Health News Source Type: news

TENSION HEADACHE (Aconitum Napellus, Carduus Marianus, Coffea Cruda, Dioscorea Villosa, Gelsemium Sempervirens, Gnaphalium Polycephalum, Iris Versicolor,) Spray [Liddell Laboratories, Inc.]
Updated Date: Feb 25, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - February 25, 2015 Category: Drugs & Pharmacology Source Type: news

Gum-chewing and headache: an underestimated trigger of headache pain in migraineurs?
Abstract Tension-type headache and migraine are currently considered the second and third most frequent human diseases. Since a variety of conditions that involve the temporomandibular joint and chewing muscles are frequent causes of orofacial pain, the aim of this article was to review current published evidence about the potential relationship between gum-chewing and headache. A systematic electronic search performed on Medline, Scopus and Web of Science using the keywords "headache" or "migraine" and "chewing" allowed to finally identify 1 cross-sectional, 1 observational and 3 randomized studies, along with 3 c...
Source: CNS and Neurological Disorders Drug Targets - February 25, 2015 Category: Drugs & Pharmacology Authors: Lippi G, Cervellin G, Mattiuzzi C Tags: CNS Neurol Disord Drug Targets Source Type: research

Changes in serum amino acids in migraine patients without and with aura and their possible usefulness in the study of migraine pathogenesis.
CONCLUSION. We found higher level of His in migraine patients without and with aura and lower level of Val and Leu in patients with migraine without aura. PMID: 25714963 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - February 25, 2015 Category: Drugs & Pharmacology Authors: Domitrz I, Koter MD, Cholojczyk M, Domitrz W, Baranczyk-Kuzma A, Kaminska A Tags: CNS Neurol Disord Drug Targets Source Type: research

How Effective Is Melatonin as a Preventive Treatment for Hemicrania Continua? A Clinic‐Based Study
ConclusionFrom this single clinic investigation, only a small percent of subjects with hemicrania continua (less than 20%) will achieve pain freedom on melatonin, thus clearly not matching the effectiveness of indomethacin. However, the addition of melatonin to indomethacin may allow around 45% of patients to have complete or partial relief of their headache with the subsequent ability to reduce or eliminate their indomethacin dosage, which may lead to a decrease in medical morbidity over time secondary to less exposure to indomethacin. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - February 25, 2015 Category: Neurology Authors: Todd D. Rozen Tags: Brief Communication Source Type: research

The effectiveness of high dose zinc acetate lozenges on various common cold symptoms: a meta-analysis
Conclusions: The effect of zinc acetate lozenges on cold symptoms may be associated with the local availability of zinc from the lozenges, with the levels being highest in the pharyngeal region. However our findings indicate that the effects of zinc ions are not limited to the pharyngeal region. There is no indication that the effect of zinc lozenges on nasal symptoms is less than the effect on the symptoms of the pharyngeal region, which is more exposed to released zinc ions.Given that the adverse effects of zinc in the three trials were minor, zinc acetate lozenges releasing zinc ions at doses of about 80 mg/day may be ...
Source: BMC Family Practice - February 25, 2015 Category: Primary Care Authors: Harri HemiläElizabeth Chalker Source Type: research

Nitric oxide donors for cervical ripening in first-trimester surgical abortion.
CONCLUSIONS: NO donors are superior to placebo or no treatment, but inferior to prostaglandins for first-trimester cervical ripening, and associated with more side effects. PMID: 25712737 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 25, 2015 Category: Journals (General) Authors: Promsonthi P, Preechapornprasert A, Chanrachakul B Tags: Cochrane Database Syst Rev Source Type: research

Discontinued Medications: Are They Really Discontinued?
A 69-year-old man with chronic atrial fibrillation and a past cerebrovascular accident treated with warfarin and aspirin presented to the emergency department with a severe headache. A STAT computed tomography (CT) scan revealed bilateral subdural hematomas. His international normalized ratio (INR) was supratherapeutic at 4.9. He was admitted to the intensive care unit, and the warfarin was stopped. After resolution of the condition, warfarin was restarted because of the high risk associated with the patient’s previous cerebrovascular accident. (Source: AORN Journal)
Source: AORN Journal - February 24, 2015 Category: Nursing Tags: Column Source Type: research

Cerebral venous thrombosis in inflammatory bowel disease
Cerebral venous thrombosis (CVT) is a rare but devastating complication of inflammatory bowel disease (IBD). Here we describe six IBD patients with cerebral venous thrombosis. The patients presented with hours to days of headache and were found to have venous thrombosis on imaging. Four of the six patients had ulcerative colitis and two had Crohn's disease. All six patients were treated with therapeutic anticoagulation. There were two deaths; one patient became comatose and died despite anticoagulation while the other recovered well from the sinus thrombosis but died after a bowel perforation 3 weeks later. This case serie...
Source: Journal of Digestive Diseases - February 24, 2015 Category: Gastroenterology Authors: Ersilia M Defilippis, Elaine Barfield, Dana Leifer, Adam Steinlauf, Brian P Bosworth, Ellen J Scherl, Robbyn Sockolow Tags: Case report Source Type: research

Behavioral Treatments for Migraine Management: Useful at Each Step of Migraine Care
Abstract Migraine is a disabling and prevalent disorder. Migraine is most effectively treated with a stepped care approach, where patients initially receive a broad level of care (primary care) and proceed to receive increasingly specialized care throughout the course of treatment. Behavioral treatments for migraine modify behaviors of people with migraine with the intention to prevent migraine episodes and secondary consequence of migraine. Behavioral treatments can be incorporated into each level of the stepped care approach for migraine treatment. In this article, we provide a rationale for including behaviora...
Source: Current Neurology and Neuroscience Reports - February 24, 2015 Category: Neuroscience Source Type: research

Efficacy of an Innovative Aerosol Foam Formulation of Fixed Combination Calcipotriol plus Betamethasone Dipropionate in Patients with Psoriasis Vulgaris
Conclusions Cal/BD foam demonstrated a significant improvement in antipsoriatic effect over Cal/BD ointment, BD foam and foam vehicle alone. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 24, 2015 Category: Drugs & Pharmacology Source Type: research

Typical aura without headache: a case report and review of the literature
Conclusions TAWH is an uncommon phenomenon of migraine. Migraine with visual aura mainly presents positive and dynamic symptoms. It has a benign course and can be diagnosed after exclusion of other organic diseases such as TIA and epilepsy. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 24, 2015 Category: Journals (General) Source Type: research

A phase 1 dose-escalation study of antibody BI-505 in relapsed/refractory multiple myeloma.
Conclusion: BI-505 can be safely administered at doses that saturate myeloma cell ICAM-1 receptors in patients. This study was registered at www.clinicaltrials.gov (NCT01025206). PMID: 25712687 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - February 24, 2015 Category: Cancer & Oncology Authors: Hansson M, Gimsing P, Badros AZ, Martinsson Niskanen T, Nahi H, Offner F, Salomo M, Sonesson E, Mau-Sorensen M, Stenberg Y, Sundberg A, Teige I, van Droogenbroeck J, Wichert S, Zangari M, Frendeus B, Korsgren M, Poelman M, Tricot G Tags: Clin Cancer Res Source Type: research

Inpatient Management of Migraine
Abstract Migraine is a frequently disabling disorder which may require inpatient treatment. Admission criteria for migraine include intractable migraine, nausea and/or vomiting, severe disability, and dependence on opioids or barbiturates. The inpatient treatment of migraine is based on observational studies and expert opinion rather than placebo-controlled trials. Well-established inpatient treatments for migraine include dihydroergotamine, neuroleptics/antiemetics, lidocaine, intravenous aspirin, and non-pharmacologic treatment such as cognitive–behavioral therapy. Short-acting treatments possibly associated ...
Source: Current Neurology and Neuroscience Reports - February 23, 2015 Category: Neuroscience Source Type: research

Intracranial Fungal Granulomas: A Single Instituitional Clinico-Pathological Study of 66 Patients and Review of Literature
Conclusion ICFG have high morbidity and mortality rates. Early diagnosis, radical surgery and antifungal treatment for 6 weeks may improve outcome. Poor neurological status of patients at the time of presentation, immunocompromised state, contamination of ventricular CSF during surgery and renal failure (due to amphotericin-B) are associated with poor outcome. (Source: World Neurosurgery)
Source: World Neurosurgery - February 23, 2015 Category: Neurosurgery Source Type: research

Prevalence of ponticuli posticus among patients referred for dental examinations by cone-beam CT
Ponticulus posticus (PP) is the bony bridge that can completely or partially embrace the vertebral artery and the suboccipital nerve root at the atlas posterior arch. The PP can be a possible cause of vertigo, vertebrobasilar insufficiency, neck pain, shoulder pain, and cervicogenic headache. Moreover, the vertebral artery injury may happen during atlas lateral mass screw insertion in the presence of PP. (Source: The Spine Journal)
Source: The Spine Journal - February 23, 2015 Category: Orthopaedics Authors: Chia-Hui Chen, Yuk-Kwan Chen, Chien-Kuo Wang Tags: Clinical studies Source Type: research

Vertebral artery hypoplasia and vertebral artery dissection: A hospital-based cohort study
Conclusions: sVAD is associated with ipsilateral VAH and occurs more frequently in hypoplastic VAs than in their normal counterparts. (Source: Neurology)
Source: Neurology - February 23, 2015 Category: Neurology Authors: Zhou, M., Zheng, H., Gong, S., Guo, J., Chen, N., Zhou, D., Yang, R., Zhu, C., He, L. Tags: Other cerebrovascular disease/ Stroke, Clinical trials Observational study (Cohort, Case control) ARTICLE Source Type: research

Rising Global Prevalence of Migraine Headaches to Drive Migraine Drugs...
Marketresearchreports.biz has added a new research report on the "Global Migraine Drugs Market 2015-2019" to its collection. Explore All Drugs Market Research Reports at...(PRWeb February 21, 2015)Read the full story at http://www.prweb.com/releases/2015/02/prweb12532536.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 22, 2015 Category: Pharmaceuticals Source Type: news

Frequency of migraine as a chief complaint in otolaryngology outpatient practice.
Conclusion. Actual diagnostic criteria for migraine do not satisfy the diversity of its presentation. Investigating the history of migraine is enough to diagnose most atypical presentations. Sound knowledge about migraine seems essential for any ENT practitioner. PMID: 25695049 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - February 22, 2015 Category: Research Authors: Sabra O, Muhammad Ali M, Al Zayer M, Altuwaijri S Tags: Biomed Res Int Source Type: research