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Headache as a manifestation of intracranial aneurysm in autosomal dominant polycystic kidney disease.
CONCLUSIONS: Similarly to ICAN and/or SAH in the family history, headache and/or other neurological symptoms should be indication for screening for ICANs in all ADPKD patients irrespectively of their age. We propose a set of criteria, which may enable detection of most cases of ICANs in ADPKD patients. PMID: 25890928 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 25, 2015 Category: Neurology Authors: Niemczyk M, Niemczyk S, Bujko M, Pączek L Tags: Neurol Neurochir Pol Source Type: research

Migraine frequency and its association with dyslipidemia in women.
CONCLUSION: TC and TG values may have an influence on migraine severity and also contribute to the increased risk of cardiovascular diseases, especially in women. PMID: 25890923 [PubMed - in process] (Source: Neurologia i Neurochirurgia Polska)
Source: Neurologia i Neurochirurgia Polska - April 25, 2015 Category: Neurology Authors: Janoska M, Chorążka K, Domitrz I Tags: Neurol Neurochir Pol Source Type: research

Traumatic Displacement of a Maxillary Primary Canine Tooth into the Middle Nasal Concha Presenting as Chronic Facial Pain: A Case Report.
Authors: Bušic N, Mihovilovic A, Poljak NK, Macan D Abstract The case of a 32-year-old woman who sustained a nasal bone fracture and dental trauma at the age of 9 is described in this article. Misdiagnosis of the dental displacement into the middle turbinate at the initial examination led to chronic facial pain. The cause of the pain was incorrectly diagnosed or misinterpreted by several medical specialists, including an otolaryngologist, neurologist, physiatrist, ophthalmologist, internist, radiologist, oral surgeon, dentist, and the patient's family physician. Finally, 23 years after the dental trauma, a multisl...
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Analysis of Pain in the Rabbit Temporomandibular Joint After Unilateral Splint Placement.
CONCLUSION: Behavioral and anatomical results were consistent with an increase in nociceptive signaling in concert with condylar remodeling driven by altered TMJ loading. Changes in excitability and action potential waveform were consistent with possible compensatory changes of TMJ afferents for an overall increase in afferent drive associated with joint degeneration. These compensatory changes may reflect pain-adaption processes that many patients with TMJ disorders experience. PMID: 25905538 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Persistent Neuropathic Pain Influences Persistence Behavior in Rats.
CONCLUSION: These results suggest that persistent pain influences behavioral regulation and that animals experiencing persistent pain may have difficulty adapting to environmental demands. PMID: 25905537 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

The Application of Neuropathic Pain Questionnaires in Burning Mouth Syndrome Patients.
CONCLUSION: Although the results of this study suggest that neuropathic pain questionnaires, such as PainDETECT and DN4, are not ideal principal screening tools for BMS patients, a substantial proportion of neuropathic symptoms in primary BMS patients were identified. PMID: 25905536 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Perceived Dental Pain: Determinants and Impact on Brazilian Schoolchildren.
CONCLUSION: A high percentage of schoolchildren suffered from dental pain, which was influenced by demographic, socioeconomic, psychosocial, and clinical characteristics, causing a negative impact on oral health perception. PMID: 25905535 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Intramuscular Temperature Modulates Glutamate-Evoked Masseter Muscle Pain Intensity in Humans.
CONCLUSION: Glutamate-evoked jaw muscle pain was significantly altered by the temperature of the injection solution. Although temperature perception in the jaw muscle is poor, pain intensity is increased when the muscle tissue temperature is elevated. PMID: 25905534 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Painful Temporomandibular Disorders Are Common in Patients with Postural Orthostatic Tachycardia Syndrome and Impact Significantly upon Quality of Life.
CONCLUSION: TMD are common in patients with PoTS. They have a significant, additional impact on patients' quality of life and should therefore be screened for at an early stage in PoTS. PMID: 25905533 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Myofascial Pain: An Open Study on the Pharmacotherapeutic Response to Stepped Treatment with Tricyclic Antidepressants and Gabapentin.
CONCLUSION: This study has demonstrated the good pharmacotherapeutic response of persistent myofascial pain, even in more severe cases. Not being a randomized controlled trial, the results may be biased and should be interpreted with caution. Patients who do not respond to TCAs may be a distinct subgroup and this needs further investigation. The results also suggest that gabapentin, at a lower dose than previously reported, is a good alternative in TCA-resistant patients. PMID: 25905532 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Comorbidity Between Depression and Anxiety in Patients with Temporomandibular Disorders According to the Research Diagnostic Criteria for Temporomandibular Disorders.
CONCLUSION: Multidimensional assessment enabled differentiation between findings of depression, anxiety, somatization, and comorbidity in subgroups of TMD patients. The findings of no statistically significant differences between subgroups of TMD patients as to anxiety and comorbidity support previous studies on TMD and anxiety, which suggest a less significant role of anxiety in chronic TMD patients as compared to depression and somatization. PMID: 25905531 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Subtyping Patients with Temporomandibular Disorders in a Primary Health Care Setting on the Basis of the Research Diagnostic Criteria for Temporomandibular Disorders Axis II Pain-Related Disability: A Step Toward Tailored Treatment Planning?
CONCLUSION: The results suggest that GCPS-related disability scoring can be used as a simple screening instrument in primary care settings to identify individuals with different, clinically relevant psychosocial subtypes. PMID: 25905530 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Hypnosis/Relaxation Therapy for Temporomandibular Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
CONCLUSION: Three RCTs were eligible for the systematic review, but they were with high risk of bias and provided low-quality evidence, suggesting that hypnosis/relaxation therapy may have a beneficial effect on maximal pain and active maximal mouth opening but not on pain and pressure pain threshold. Larger RCTs with low risk of bias are required to confirm or refute these findings and to inform other important patient outcomes. PMID: 25905529 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Neurocognition and Neuroplasticity: What Does It All Mean for Clinical Practice?
Authors: Palla S Abstract No abstract available. PMID: 25905528 [PubMed - as supplied by publisher] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - April 24, 2015 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Topical Gel Promising in Migraine Topical Gel Promising in Migraine
A ketoprofen gel applied on the face over transgeminal nerve endings is effective in migraine treatment and an alternative to those who can't take oral NSAIDs. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 24, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Neurostimulation Therapies for Primary Headache Disorders: Present and Future
No abstract available (Source: Topics in Pain Management)
Source: Topics in Pain Management - April 24, 2015 Category: Anesthesiology Tags: CME Article Source Type: research

Neurotoxicity of intrathecal 6% hydroxyethyl starch 130/0.4 injection in a rat model
Summary Epidural blood patch is the gold standard treatment for post‐dural puncture headache, although hydroxyethyl starch may be a useful alternative to blood if the latter is contraindicated. The aim of this experimental study was to assess whether hydroxyethyl starch given via an indwelling intrathecal catheter resulted in clinical or histopathological changes suggestive of neurotoxicity. The study was conducted in rats that were randomly allocated to receive three 10‐μl injections on consecutive days of either saline or hydroxyethyl starch administered via the intrathecal catheter. Eight rats were given injections...
Source: Anaesthesia - April 24, 2015 Category: Anesthesiology Authors: O. Vassal, P. Del Carmine, P.‐A. Beuriat, F.‐P. Desgranges, N. Gadot, B. Allaouchiche, Q. Timour‐Chah, A. Stewart, D. Chassard Tags: Original Article Source Type: research

Pediatric Migraine Variants: a Review of Epidemiology, Diagnosis, Treatment, and Outcome
This article aims to review the pathophysiology, evaluation, and management of the pediatric migraine variants including abdominal migraine, benign paroxysmal vertigo, cyclic vomiting syndrome, and benign paroxysmal torticollis as well as the episodic syndromes that may lead to migraine, infantile colic, alternating hemiplegia of childhood, and vestibular migraine. (Source: Current Neurology and Neuroscience Reports)
Source: Current Neurology and Neuroscience Reports - April 23, 2015 Category: Neuroscience Source Type: research

Clinical manifestations of herpes zoster, its comorbidities, and its complications in north of iran from 2007 to 2013.
Conclusion. Shortening interval between skin lesion manifestation and starting medication can accelerate lesion improvement and decrease disease course, extension, and complication. PMID: 25893116 [PubMed] (Source: Neurology Research International)
Source: Neurology Research International - April 23, 2015 Category: Neurology Tags: Neurol Res Int Source Type: research

Chronic Migraines Take Big Toll on Families, Survey Finds
Debilitating headaches meant less participation in family activities, canceled plans each month Source: HealthDay Related MedlinePlus Pages: Family Issues, Migraine (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 23, 2015 Category: Consumer Health News Source Type: news

Chronic Migraines Take Big Toll on Families, Survey Finds
Title: Chronic Migraines Take Big Toll on Families, Survey FindsCategory: Health NewsCreated: 4/22/2015 12:00:00 AMLast Editorial Review: 4/23/2015 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - April 23, 2015 Category: Neurology Source Type: news

Acute post-traumatic stress symptoms and age predict outcome in military blast concussion
High rates of adverse outcomes have been reported following blast-related concussive traumatic brain injury in US military personnel, but the extent to which such adverse outcomes can be predicted acutely after injury is unknown. We performed a prospective, observational study of US military personnel with blast-related concussive traumatic brain injury (n = 38) and controls (n = 34) enrolled between March and September 2012. Importantly all subjects returned to duty and did not require evacuation. Subjects were evaluated acutely 0–7 days after injury at two sites in Afghanistan and again 6–12 months later in t...
Source: Brain - April 23, 2015 Category: Neurology Authors: Mac Donald, C. L., Adam, O. R., Johnson, A. M., Nelson, E. C., Werner, N. J., Rivet, D. J., Brody, D. L. Tags: Original Articles Source Type: research

64 Year‐Old Woman with Longstanding Migraine
(Source: Brain Pathology)
Source: Brain Pathology - April 23, 2015 Category: Neurology Authors: Ivan Fernandez‐Vega, Antonio Saiz, Jorge Santos‐Juanes, Kelvin Piña‐Batista, Maria Daniela Corte‐Torres, Aurora Astudillo Tags: CASE OF MONTH JANUARY 2015 Source Type: research

Glioblastoma multiforme with epithelial differentiation: A potential diagnostic pitfall in cerebrospinal fluid cytology
Cerebrospinal fluid (CSF) cytology provides valuable diagnostic and prognostic information for diseases of the central nervous system (CNS) and remains the gold standard for the detection of neoplastic meningitis. Metastatic involvement of the CSF by non‐CNS neoplasms far surpasses that of primary brain tumors, although conventional glioblastoma multiforme (GBM) can occasionally be identified in the CSF. GBM with epithelial differentiation is an uncommon variant that may contain features such as adenoid structures, signet ring cells, or squamous metaplasia. Herein, we present a case of GBM with epithelial differentiation...
Source: Diagnostic Cytopathology - April 23, 2015 Category: Pathology Authors: Simpal K. Gill, Vijayalakshmi Padmanabhan, William F. Hickey, Jonathan D. Marotti Tags: Brief Report Source Type: research

Managing headache
Contrary to popular belief, headaches are very common in children and adolescents with an overall prevalence of around 60%. Migraine and tension-type headache are the most common types seen in outpatients. Rarely are they an indicator of serious pathology, but anxiety among parents and general practitioners often leads to referral. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - April 23, 2015 Category: Pediatrics Authors: Catharine P. White Tags: Personal practice Source Type: research

Clinical Experience With Continuous Intrathecal Baclofen Trials Prior to Pump Implantation
Conclusions Continuous trials via an external catheter could be an option if patients and clinicians desire a comprehensive assessment of systemic and functional effects of ITB before pump implantation. The majority of AEs were minor and resolved spontaneously, and the most effective starting intrathecal dose was determined by pump insertion. (Source: PMandR)
Source: PMandR - April 23, 2015 Category: Rehabilitation Source Type: research

Time to take tension‐type headache seriously
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - April 23, 2015 Category: Internal Medicine Authors: S. Jarvis Tags: Editorial Source Type: research

The burden of headache: global and regional prevalence of headache and its impact
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - April 23, 2015 Category: Internal Medicine Authors: A. Dowson Tags: Perspective Source Type: research

Headache: muscle tension, trigger points and referred pain
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - April 23, 2015 Category: Internal Medicine Authors: L. Arendt‐Nielsen Tags: Perspective Source Type: research

Treatment guidelines: implications for community‐based headache treatment
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - April 23, 2015 Category: Internal Medicine Authors: L. Bendtsen Tags: Perspective Source Type: research

Community‐based headache management
(Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - April 23, 2015 Category: Internal Medicine Authors: T. Maguire Tags: Perspective Source Type: research

Up-regulation of calcitonin gene-related peptide in trigeminal ganglion following chronic exposure to paracetamol in a CSD migraine animal model
1. Short-term treatment with APAP does not have any effect on the CGRP expression in TG.2. Short-term treatment with APAP can attenuate the CGRP expression in TG induced by CSD activation.3. Long-term treatment with APAP can up-regulates CGRP expression in TG.4. Up-regulation of CGRP is enhanced in long term APAP treatment in combination with CSD activation. (Source: Neuropeptides)
Source: Neuropeptides - April 23, 2015 Category: Neuroscience Authors: Waranurin Yisarakun, Weera Supornsilpchai, Chattraporn Chantong, Thananya Thongtan, Anan Srikiatkhachorn, Preecha Reuangwechvorachai, Supang Maneesri-le Grand Source Type: research

Short-lasting unilateral neuralgiform headache attacks with ispilateral facial flushing is a new variant of paroxysmal extreme pain disorder
Conclusions: Gain-of-function mutations in Nav1.7 are well known to cause paroxysmal extreme pain disorder (PEPD), a painful Na-channelopathy characterized by attacks of excruciating deep burning pain in the rectal, ocular, or jaw areas. The SCN9A mutation suggests that our patients had a phenotype of PEPD with a predominant symptom of short-lasting, severe, unilateral headache. (Source: BioMed Central)
Source: BioMed Central - April 22, 2015 Category: Journals (General) Authors: Noboru ImaiNoriko MiyakeYoshiaki SaitoEmiko KobayashiMasako IkawaShinya ManakaMasaaki ShiinaKazuhiro OgataNaomichi Matsumoto Source Type: research

Subclinical hypothyroidism in children and adolescents: is it clinically relevant?
Authors: Gawlik A, Such K, Dejner A, Zachurzok A, Antosz A, Malecka-Tendera E Abstract Although subclinical hypothyroidism (SH) is a common clinical problem, its diagnosis tends to be incidental. According to the definition, it should be asymptomatic, only detectable by screening. The presence or coincidence of any symptoms leads to L-thyroxine treatment. The clinical presentation, especially in younger patients with subclinical hypothyroidism, is still under dispute. Accordingly, the aim of this paper was to review the literature from the past seven years. The literature search identified 1,594 potentially relevan...
Source: International Journal of Endocrinology - April 22, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Successful Treatment of a Massive Metoprolol Overdose Using Intravenous Lipid Emulsion and Hyperinsulinemia/Euglycemia Therapy
We describe the case of a 59‐year‐old man who intentionally ingested ~7.5 g of metoprolol tartrate. Initial treatment of bradycardia and hypotension included glucagon, atropine, dopamine, and norepinephrine. Despite these treatment modalities, the patient developed cardiac arrest. Intravenous lipid emulsion (ILE) and hyperinsulinemia/euglycemia (HIE) therapies were initiated during advanced cardiac life support and were immediately followed by return of spontaneous circulation. Further treatment included gastric lavage, activated charcoal, continued vasopressor therapy, and a repeat bolus of ILE. The patient was weane...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 22, 2015 Category: Drugs & Pharmacology Authors: Cassie A. Barton, Nathan B. Johnson, Nathan D. Mah, Gillian Beauchamp, Robert Hendrickson Tags: Case Report Source Type: research

Memantine Extended Release (28 mg Once Daily): A Review of Its Use in Alzheimer’s Disease
Abstract Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist that is a well-established treatment option for moderate to severe dementia of the Alzheimer’s type, either alone or in combination with cholinesterase inhibitors. The immediate-release (IR) formulations of memantine (tablets and oral solution) have been available in numerous countries, including the USA, for more than a decade and are administered orally twice daily at a maximum recommended total daily dosage of 20 mg/day. The memantine extended-release (ER) (Namenda XR®) 28 mg once-daily capsule formulation was approved i...
Source: Drugs - April 22, 2015 Category: Drugs & Pharmacology Source Type: research

Elderly Woman With Headache
Publication date: May 2015 Source:Annals of Emergency Medicine, Volume 65, Issue 5 Author(s): Rachel A. Lindor , Michael J. Laughlin Jr. , Annie T. Sadosty (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - April 22, 2015 Category: Emergency Medicine Source Type: research

Fasting Lipid and Lipoproteins Concentrations in Pregnant Women With a History of Migraine
ConclusionPregnant migraineurs had elevated odds of dyslipidemia, particularly hypercholesterolemia, elevated LDL, and total cholesterol : HDL ratio as compared with pregnant non‐migraineurs. The observed associations were more pronounced among obese migraineurs. Our findings add to the accumulating evidence of adverse cardiometabolic risk profiles among migraineurs and extend these associations to pregnant women. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Bizu Gelaye, Gloria T. Larrabure‐Torrealva, Chunfang Qiu, Miguel Angel Luque‐Fernandez, B. Lee Peterlin, Sixto E. Sanchez, Michelle A. Williams Tags: Research Submission Source Type: research

Dr. Nat Blau, The City of London Migraine Clinic and the Esterhazy Orchestra: The American Connection
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Harvey Blumenthal Tags: Vox Clamantis Source Type: research

Topiramate and Nephrolithiasis: A Response
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Amanda Raff, Yasmin Idu Jion, Brian M Grosberg, Randolph W. Evans Tags: Comment Observation and Rebuttals Source Type: research

German Language Adaptation of the Headache Management Self‐Efficacy Scale (HMSE‐G) and Development of a New Short Form (HMSE‐G‐SF)
ConclusionsBoth the 25‐item version and the 6‐item version appear to be valid, reliable measures of self‐efficacy beliefs. These scales will allow clinicians to identify headache sufferers with low levels of headache‐specific self‐efficacy with the goal of enhancing this expectancy for improvement. The new short form can help accomplish this goal without adding significantly to the burden of the self‐report assessment batteries used in clinical settings. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Julia E. Graef, Winfried Rief, Douglas J. French, Paul Nilges, Yvonne Nestoriuc Tags: Research Submission Source Type: research

Post‐Craniotomy Headache: A Clinical View With a Focus on the Persistent Form
ConclusionsPost‐craniotomy headaches can have significant repercussions on patients' quality of life. There is a need for clinical trials evaluating therapeutic options for treatment of this type of headache. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Pedro Augusto Sampaio Rocha‐Filho Tags: Headache Currents Source Type: research

Headache, Cerebral Aneurysms, and the Use of Triptans and Ergot Derivatives
ConclusionAssociations between some headaches and aneurysms may exist. Some chronic headaches may respond to surgical aneurysm repair while others may worsen. These associations are undefined by current literature because of variable results, study methods, and limited data. Prospective studies are needed which incorporate pre‐ and post‐procedure headache character and diagnosis, aneurysm characteristics, type of aneurysm repair, associated risk factors for worsening post‐procedure headache, and ultimately combining all of these data to better predict headache outcome following surgical aneurysm treatment. Lastly, th...
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Eric P. Baron Tags: Headache Currents Source Type: research

The Role of Fear of Pain in Headache
ConclusionsFOP differentiates migraineurs from those without headache and plays a significant role in primary headache, particularly in headache‐related disability. Findings build upon and extend those from previous chronic pain studies and highlight the need for longitudinal and experimental studies to further explore this construct in headache. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - April 22, 2015 Category: Neurology Authors: Anna Katherine Black, Joshua C. Fulwiler, Todd A. Smitherman Tags: Research Submission Source Type: research

Antiepileptic drug prescribing patterns in Iraq and Afghanistan war veterans with epilepsy
We examined patterns of antiepileptic drug (AED) use in a cohort of Iraq/Afghanistan war veterans (IAVs) who were previously identified as having epilepsy. We hypothesized that clinicians would be more likely to prescribe newer AEDs and would select specific AEDs to treat seizures based on patient characteristics including gender and comorbidities. Methods From the cohort of IAVs previously identified with epilepsy between fiscal years 2009 and 2010, we selected those who received AEDs from the Veterans Health Administration in FY2010. Regimens were classified as monotherapy or polytherapy, and specific AED use was examin...
Source: Epilepsy and Behavior - April 22, 2015 Category: Neurology Source Type: research

Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back‐translational research
There are currently eight groups of drugs for the pharmacotherapy of vertigo, nystagmus, and cerebellar disorders: antiemetics; anti‐inflammatories, antimenieres, and antimigraineous medications; antidepressants, anticonvulsants, aminopyridines, and acetyl‐dl‐leucine (“the eight A's”). In acute unilateral vestibulopathy, corticosteroids improve the recovery of peripheral vestibular function, but there is not sufficient current evidence for a general recommendation. There is also insufficient evidence that 48 or 144 mg/day betahistine has an effect in Ménière's disease. Therefore, higher dosages are currently re...
Source: Annals of the New York Academy of Sciences - April 22, 2015 Category: Science Authors: Michael Strupp, Andreas Zwergal, Katharina Feil, Tatiana Bremova, Thomas Brandt Tags: Original Article Source Type: research

Classification of headache
Headaches are prevalent and a very common presentation for medical care. It is therefore important to have a systemic classification to aid in the evaluation and treatment of these disorders. Attempts at classification began in ancient times1,2 and continued through the 20th century.3 Various authors published different classification schemes in the middle 20th century.4–6 (Source: Disease a Month)
Source: Disease a Month - April 22, 2015 Category: Infectious Diseases Authors: Thomas Freedom Tags: Review article Source Type: research

The Study of Headache in the 1950s in Latin America by Edgard Raffaelli Júnior (1930-2006).
Abstract The aim of this study was to review the life of Edgard Raffaelli Júnior (1930-2006) and to summarize his important contributions to the study of headaches. He was the first doctor to study headaches in Latin America, and for 50 years he advanced the understanding of headaches worldwide. He was born in São Paulo, Brazil, on March 2, 1930 and died on December 29, 2006. He founded the Brazilian Headache Society and was one of the organizers and founders of the International Headache Society. Following Raffaelli, many Latin American doctors have since been inspired to study headaches. PMID: 25904384 [Pub...
Source: Headache - April 22, 2015 Category: Neurology Authors: Silva-Néto RP Tags: Headache Source Type: research

Fasting Lipid and Lipoproteins Concentrations in Pregnant Women With a History of Migraine.
CONCLUSION: Pregnant migraineurs had elevated odds of dyslipidemia, particularly hypercholesterolemia, elevated LDL, and total cholesterol : HDL ratio as compared with pregnant non-migraineurs. The observed associations were more pronounced among obese migraineurs. Our findings add to the accumulating evidence of adverse cardiometabolic risk profiles among migraineurs and extend these associations to pregnant women. PMID: 25904286 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 22, 2015 Category: Neurology Authors: Gelaye B, Larrabure-Torrealva GT, Qiu C, Luque-Fernandez MA, Peterlin BL, Sanchez SE, Williams MA Tags: Headache Source Type: research

Dr. Nat Blau, The City of London Migraine Clinic and the Esterhazy Orchestra: The American Connection.
PMID: 25904198 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - April 22, 2015 Category: Neurology Authors: Blumenthal H Tags: Headache Source Type: research