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Spontaneous cerebrospinal fluid leak following a pilates class: a case report
A noteworthy case of a 42 year-old women who developed a low-pressure headache following a pilates class. Magnetic resonance imaging revealed extensive extradural cerebrospinal fluid collections; the authors suggest pilates may be a risk factor for the development of spontaneous cerebrospinal fluid leaks. (Source: BioMed Central)
Source: BioMed Central - December 21, 2014 Category: Journals (General) Authors: James DavisIrini YannySukhdev ChatuPatrick DuboisBu HayeeNick Moran Source Type: research

Safety of a novel formulation of ibuprofen sodium compared with standard ibuprofen and placebo.
Conclusion: IBUNa has a favorable safety profile comparable to those of standard IBU tablets and placebo in single-dose studies evaluating analgesic or antipyretic efficacy. ClinicalTrials.gov Registry Numbers: Dental pain studies: NCT01098747 and NCT01216163; headache studies: NCT01077973 and NCT01362491; pyresis study: NCT01035346. PMID: 25526232 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - December 20, 2014 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain
Publication date: February 2015 Source:Brain, Behavior, and Immunity, Volume 44 Author(s): Susannah S. Lewis , Mark R. Hutchinson , Morin M. Frick , Yingning Zhang , Steven F. Maier , Tarek Sammakia , Kenner C. Rice , Linda R. Watkins We have recently shown that several classes of glucuronide metabolites, including the morphine metabolite morphine-3-glucuronide and the ethanol metabolite ethyl glucuronide, cause toll like receptor 4 (TLR4)-dependent signaling in vitro and enhanced pain in vivo. Steroid hormones, including estrogens and corticosterone, are also metabolized through glucuronidation. Here we demonstrate that...
Source: Brain, Behavior, and Immunity - December 20, 2014 Category: Neurology Source Type: research

West Africa: Mystery Over Ebola Survivors' Ailments
[IRIN]Dakar -For some Ebola survivors, overcoming the lethal viral assault has not heralded a full return to good health. An array of ailments including headache, joint pains, vision and hearing problems have afflicted convalescents; experts are still uncertain of the exact cause. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 19, 2014 Category: African Health Source Type: news

Demonstration of Cerebrospinal Fluid Leakage on Radionuclide Cisternography by SPECT/CT
We report a case of a 37-year-old woman with severe headache provoked by postural changes who was referred to the nuclear medicine department for radionuclide cisternography to demonstrate suspected cerebrospinal fluid leakage. There was an increased uptake laterally on the left paraspinal region of upper thoracal spine and posteriorly on the upper cervical region. Fused SPECT/CT images located the exact leakage site as at the first costovertebral junction level on the left side laterally and on the posterior region of the first and second cervical spine. The treatment with epidural blood patch was successful. (Source: Cli...
Source: Clinical Nuclear Medicine - December 19, 2014 Category: Radiology Tags: Interesting Images Source Type: research

High-altitude headache and acute mountain sickness
Conclusions Symptom escalation seems to be present along the continuum containing HAH, AMS, and high-altitude cerebral oedema. (Source: Neurologia)
Source: Neurologia - December 19, 2014 Category: Neurology Source Type: research

A “Lifesaving” Migraine Attack
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - December 19, 2014 Category: Neurology Authors: Matteo Fuccaro, Francesco Causin, Nicoletta Freddi, Giorgio Zanchin, Ferdinando Maggioni Tags: Images from Headache Source Type: research

Clinical Trials Update 2014: Year in Review
This section of Headache annually reviews the status of recently completed and ongoing major clinical trials involving common headache disorders. The review will focus on multicenter trials of new therapies as well as novel formulations of previously approved therapeutics. Table 1 summarizes the major therapeutic headache trials that were ongoing at the end of 2014, according to data obtained from both the “ClinicalTrials.Gov” website and from corporate press releases and presentations. Title Conditions Interventions Phases Single‐ascending dose study of AMG 333 in healthy subjects and subjects with migra...
Source: Headache: The Journal of Head and Face Pain - December 19, 2014 Category: Neurology Authors: Stephen J. Peroutka Tags: Feature Article Source Type: research

Headache in epilepsy patients: The (un)awareness of this phenomenon among Dutch neurologists
Conclusions These results show that the occurrence of headache in people with epilepsy is underestimated by Dutch neurologists. This leaves an often bothersome and potentially treatable condition underexposed. (Source: Seizure)
Source: Seizure - December 19, 2014 Category: Neurology Source Type: research

Reversible cerebral vasoconstriction syndrome as a cause of thunderclap headache: a retrospective case series study
Thunderclap headache (TCH) is a common Emergency Department presentation. Although subarachnoid hemorrhage (SAH) should be the first diagnosis to exclude, reversible cerebral vasoconstriction syndrome (RCVS) is an important alternative cause, which may be commoner than appreciated. RCVS is characterized by multifocal narrowing of cerebral arteries, typically manifested by acute, severe headache with or without neurological deficits. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 19, 2014 Category: Emergency Medicine Authors: Athanasios Papathanasiou, Vasiliki Zouvelou, David P. Breen, Timothy J. Phillips, Anjum Misbahuddin, Sanjiv Chawda, Rajith de Silva Tags: Case Reports Source Type: research

Behavioral disorders as unusual presentation of pediatric extraventricular neurocytoma: report on two cases and review of the literature
Conclusion: In childhood, the attention/hyperactivity disorders seem to be often over-diagnosed. When these deficits are more subtle and do not well-fit in a specific neurocognitive disorder, the clinicians should have a suspicion that they might mask the clinical features of a frontal lesion. This paper is focused on the clinical presentation of the extraventricular neurocytoma and the possible organic etiology of an attention and hyperactivity deficit. (Source: BMC Neurology)
Source: BMC Neurology - December 19, 2014 Category: Neurology Authors: Raffaella MessinaMaria CefaloDomitilla SeccoSimona CappellettiErika RebessiAndrea CaraiGiovanna ColafatiFrancesca Diomedi CamasseiAntonella CacchioneCarlo MarrasAngela Mastronuzzi Source Type: research

A case of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome presenting with hypertrophic pachymeningitis
A 43-year-old woman with a 3-year history of headache, fever, and swelling of the forehead, presented to our hospital. A general examination revealed palmar and plantar pustules. Blood analyses showed an elevated white blood cell count, C-reactive protein level, and erythrocyte sedimentation rate. Brain MRI revealed a partially thickened cranial bone with gadolinium enhancement, and also abnormally enhanced dura mater. Bone scintigraphy showed involvement of the cranial bone and bilateral sternoclavicular joints. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 19, 2014 Category: Neurology Authors: Wataru Shiraishi, Shintaro Hayashi, Yasutaka Iwanaga, Hiroyuki Murai, Akifumi Yamamoto, Jun-ichi Kira Tags: Clinical Short Communication Source Type: research

Phase I study of the novel Cdc2/CDK1 and AKT inhibitor terameprocol in patients with advanced leukemias
Conclusion Terameprocol can be safely administered to advanced leukemia patients, sufficient drug exposure was obtained and clinical activity and biomarker modulation were observed. (Source: Investigational New Drugs)
Source: Investigational New Drugs - December 18, 2014 Category: Drugs & Pharmacology Source Type: research

Migraine Linked to Risk for Bell's PalsyMigraine Linked to Risk for Bell's Palsy
Researchers report a novel association between migraine and Bell's palsy, a condition causing facial nerve paralysis. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - December 18, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Application of psychometric testing for validation in the field of orofacial pain.
Authors: Heir GM, Jaeger B, Schwartz A PMID: 25507657 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - December 18, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Retraction.
Authors: PMID: 25507656 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - December 18, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Stress and patients' ability to comply with or adhere to treatment regimens.
Authors: Eli I PMID: 25507655 [PubMed - in process] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - December 18, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research

Lateralizing sensorimotor deficits in a case of pseudopheochromocytoma.
Authors: Suh J, Quinn C, Rehwinkel A Abstract Pseudopheochromocytoma is a poorly understood, rare cause of severe paroxysmal hypertension that mimics the symptomatology of pheochromocytoma in the absence of biochemical evidence of this tumor. Symptoms such as headache, nausea, sweating, and palpitations during hypertensive episodes have been described. In this paper, we describe previously unreported findings of lateralizing sensorimotor deficits in a patient with pseudopheochromocytoma. These changes presented during a hypertensive episode and were concerning for stroke but were not accompanied by acute radiologic...
Source: The Yale Journal of Biology and Medicine - December 18, 2014 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Migraine May Raise Risk for Bell's Palsy, Study Suggests
Title: Migraine May Raise Risk for Bell's Palsy, Study SuggestsCategory: Health NewsCreated: 12/17/2014 12:00:00 AMLast Editorial Review: 12/18/2014 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - December 18, 2014 Category: Neurology Source Type: news

Mycoplasma pneumoniae as a causative agent of community-acquired pneumonia in children: clinical features and laboratory diagnosis
Conclusions: There are no characteristic radiological findings, or routine laboratory tests that would distinguish CAP caused by Mycoplasma pneumoniae from other CAP. It was found that clinical features such as headache and wheezing are indicative for Mycoplasma pneumoniae infection. Furthermore, it was found that during the acute phase of disease, detection of IgM antibodies in combination with RT-PCR allows for precise and reliable diagnosis of Mycoplasma pneumoniae infections in children. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - December 18, 2014 Category: Pediatrics Authors: Biljana MedjoMarina Atanaskovic-MarkovicSnezana RadicDimitrije NikolicMarija LukacSlobodanka Djukic Source Type: research

Migraine Linked to Bell Palsy Risk (FREE)
By Christine Sadlowski Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM Migraine may be a risk factor for the facial paralysis known as Bell palsy, a … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 18, 2014 Category: Primary Care Source Type: news

Diffuse cerebral vasospasm with infarct after intrathecal cytarabine in childhood leukemia
Abstract Although the varied neurotoxicity of intrathecal (IT) chemotherapy for treatment of childhood acute leukemia is well known, most are related to transient post‐puncture headache, drug‐induced arachnoiditis, or leukoencephalopathy after methotrexate or cytarabine. Cerebral vasospasm leading to acute infarct after IT chemotherapy is very uncommon in children. Reported herein is a rare case of diffuse cerebral vasospasm with subsequent cerebral infarct after IT cytarabine in a 7‐year‐old boy with acute lymphoblastic leukemia, who successfully recovered with supportive management, and a review of the literature...
Source: Pediatrics International - December 18, 2014 Category: Pediatrics Authors: Jong Hyung Yoon, Ju Young Yoon, Hyeon Jin Park, Meong Hi Son, Su‐Hyun Kim, Woojun Kim, Ho Jin Kim, Sang Hyun Lee, Byung‐Kiu Park Tags: Patient Report Source Type: research

Learn from a case with glabellar ecchymosis and headache: Variety of pain associated ecchymosis
(Source: Psychiatry and Clinical Neurosciences)
Source: Psychiatry and Clinical Neurosciences - December 18, 2014 Category: Neuroscience Authors: Yosuke Kakisaka, Mayu Fujikawa, Naomi Hino‐Fukuyo Tags: Letter to the Editor Source Type: research

Clinically Mild Encephalitis with a Reversible Splenial Lesion (MERS) after Mumps Vaccination
We retrospectively collected three patients with clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination, and reviewed five patients, including two patients previously reported. The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21days after mumps vaccination. Consciousness disturbance, delirious behavior, seizures, or dysarthria were observed on days 1 to 3, which had completely resolved before day 11. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 18, 2014 Category: Neurology Authors: Jun-ichi Takanashi, Takashi Shiihara, Takeshi Hasegawa, Masaru Takayanagi, Munetsugu Hara, Akihisa Okumura, Masashi Mizuguchi Tags: Short communication Source Type: research

Transcranial direct current stimulation in the prophylactic treatment of migraine based on interictal visual cortex excitability abnormalities: A pilot randomized controlled trial
(i) to compare the excitability of visual cortex in migraine patients with healthy volunteers; (ii) if an abnormal excitability has been found, to modulate cortical excitability in migraine patients with transcranial direct current stimulation (tDCS) and observe their clinical and neurophysiological effects. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - December 18, 2014 Category: Neurology Authors: Sérgio Rocha, Lorena Melo, Camilla Boudoux, Águida Foerster, Daniella Araújo, Katia Monte-Silva Source Type: research

Headache in epilepsy patients: The (un)awareness of this phenomenon among Dutch neurologists
Headache is one of the most frequent complaints heard by a general practitioner or a neurologist. It is a problem that is experienced by 80% of the general population anywhere during their life and when calculated globally, numbers are found of 47% of the general population suffering from current headaches, 10% of current migraine and 38% of current tension type headache 1;2. In fact, migraine and tension type headaches are a major burden on both the health system and health cost 1;3. As far back as in 1898, an editorial in the Journal of American Medical Association noted that there was a need to find “a plausible expla...
Source: Seizure: European Journal of Epilepsy - December 18, 2014 Category: Neurology Authors: WA Hofstra, G Hageman, AW de Weerd Source Type: research

Migraine May Raise Risk for Bell's Palsy, Study Suggests
The headaches were tied to a doubling of odds for the facial paralysis, researchers say (Source: WebMD Health)
Source: WebMD Health - December 17, 2014 Category: Consumer Health News Source Type: news

Migraine May Raise Risk for Bell's Palsy
The headaches were tied to a doubling of odds for the facial paralysis, researchers say Source: HealthDay Related MedlinePlus Pages: Bell's Palsy, Migraine (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 17, 2014 Category: Consumer Health News Source Type: news

[Review] Migraine pathophysiology: lessons from mouse models and human genetics
Migraine is a common, disabling, and undertreated episodic brain disorder that is more common in women than in men. Unbiased genome-wide association studies have identified 13 migraine-associated variants pointing at genes that cluster in pathways for glutamatergic neurotransmission, synaptic function, pain sensing, metalloproteinases, and the vasculature. The individual pathogenetic contribution of each gene variant is difficult to assess because of small effect sizes and complex interactions. Six genes with large effect sizes were identified in patients with rare monogenic migraine syndromes, in which hemiplegic migraine...
Source: Lancet Neurology - December 17, 2014 Category: Neurology Authors: Michel D Ferrari, Roselin R Klever, Gisela M Terwindt, Cenk Ayata, Arn M J M van den Maagdenberg Tags: Review Source Type: research

[Review] Functional MRI of migraine
Migraine is a disabling neurological condition manifesting with attacks of headache, hypersensitivities to visual, auditory, olfactory and somatosensory stimuli, nausea, and vomiting. Exposure to sensory stimuli, such as odours, visual stimuli, and sounds, commonly triggers migraine attacks, and hypersensitivities to sensory stimuli are prominent during migraine attacks, but can persist with less magnitude between attacks. Functional MRI (fMRI) has been used to investigate the mechanisms that lead to migraine sensory hypersensitivities by measuring brain responses to visual, olfactory, and painful cutaneous stimulation, an...
Source: Lancet Neurology - December 17, 2014 Category: Neurology Authors: Todd J Schwedt, Chia-Chun Chiang, Catherine D Chong, David W Dodick Tags: Review Source Type: research

HEADACHE RELIEF (Acetaminophen, Aspirin, Caffeine) Tablet [TARGET Corporation]
Updated Date: Dec 17, 2014 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 17, 2014 Category: Drugs & Pharmacology Source Type: news

A Wearable Epidural Catheter Infusion System for Patients With Intractable Spontaneous Intracranial Hypotension
Conclusions: This wearable epidural catheter infusion system showed promising efficacy results but the high rate of complications limits its use to a very select group of patients. (Source: Regional Anesthesia and Pain Medicine)
Source: Regional Anesthesia and Pain Medicine - December 17, 2014 Category: Anesthesiology Tags: Original Articles Source Type: research

Retrospective Study of Epidural Blood Patch Use for Spontaneous Intracranial Hypotension
Conclusions: Our study suggests that the response to the EBP is related to the severity of symptoms but not to the number and locations of cisternographic CSF leakages. (Source: Regional Anesthesia and Pain Medicine)
Source: Regional Anesthesia and Pain Medicine - December 17, 2014 Category: Anesthesiology Tags: Original Articles Source Type: research

Acute acalculous cholecystitis (AAC) in the pediatric population associated with Epstein–Barr Virus (EBV) infection. Case report and review of the literature
We present a teenager with acute cholecystitis associated with EBV acute infection. Acute acalculous cholecystitis accounts for 2–15% of all cases of acute cholecystitis. Few cases of acute cholecystitis have been reported during the course of primary EBV infection. Case report A 15-year-old female who came to the JDCH ER complaining of 3 days history of mild diffuse abdominal pain associated with two episodes of emesis. She also reports headache as well as a mild cough and low grade subjective fever. Blood test results showed mild leukocytosis with significant elevation in the lymphocytes (59%), High alkaline phosphata...
Source: International Journal of Surgery Case Reports - December 17, 2014 Category: Surgery Source Type: research

Postmarketing Review of Intravenous Acetaminophen Dosing Based on Food and Drug Administration Prescribing Guidelines
ConclusionIntravenous acetaminophen appeared to be a safe and effective analgesic and antipyretic agent. Dosing for patients weighing less than 50 kg needs to be appropriately weight adjusted. Intravenous acetaminophen can be used alone or in conjunction with opioids and other analgesics. Limitations of this study include its retrospective design, inability to assess outcomes of reducing opioid use, and short‐term observation period. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 17, 2014 Category: Drugs & Pharmacology Authors: Catherine dela Cruz Ubaldo, Natalie Semaan Hall, Brenden Le Tags: Original Research Article Source Type: research

Emotionally induced galactorrhoea in a non-lactating female -"Pseudo- Lactation"?
Conclusion: The strong temporal relationship between her symptoms and emotional attachment to the newborn with exclusion of other causes on clinical, biochemical and radiological evidence, raises the possibility that transient hyperprolactinaemia was due to a transient lactotroph hyperplasia and hyper function which had been triggered by the stimulatory cues from the newborn.Emotionally induced "pseudo lactation" may be a rare but important cause for transient hyperprolactinaemia in a non-lactating female. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - December 17, 2014 Category: Endocrinology Authors: Harsha DissanayakeSisil KeerthisenaChinthana DematapitiyaPrasad Katulanda Source Type: research

Esophageal Mucosal Impedance: Is It Time to Forgo Prolonged Gastroesophageal Reflux Recordings?
For several decades, ambulatory 24-hour esophageal pH monitoring remained the sole tool for the assessment of gastroesophageal reflux. This tool, first introduced in 1969, is still being used to determine the extent of esophageal acid exposure in patients with gastroesophageal reflux disease (GERD) with typical or atypical symptoms, patients who are candidates for surgical fundoplication and those who do respond to antireflux treatment.1,2 However, it has been repeatedly demonstrated that the catheter-based pH testing interferes with patients’ reflux-provoking activities (food consumption, smoking, sleep, etc) primarily ...
Source: Gastroenterology - December 17, 2014 Category: Gastroenterology Authors: Ronnie Fass Tags: Editorial Source Type: research

Isolated middle cerebral artery dissection: a systematic review
Abstract Acute stroke can be missed in the emergency department, particularly in younger patients and in those with more vague symptoms such as headache or dizziness. Cervicocephalic dissections are one group of etiologies for acute stroke in the young. While cervicocephalic dissections are not uncommon in clinical practice, isolated middle cerebral artery dissection (MCAD) has been rarely reported as a cause for stroke. We sought to review the clinical implications and pathophysiology of an isolated MCAD. We searched the medical literature for isolated MCAD in clinical stroke patients using MEDLINE, HighWire, an...
Source: International Journal of Emergency Medicine - December 17, 2014 Category: Emergency Medicine Source Type: research

How painkillers really can relieve a headache brought on by foreigners
A Ukip candidate recently resigned after making racist and homophobic comments. The excuse offered was that this was due to his being under the influence of prescription medication. Many have scoffed at this explanation, but is there any scientific basis to the claim that painkillers can cause racism or other bigotry? Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - December 16, 2014 Category: Science Authors: Dean Burnett Tags: Science UK Independence party (Ukip) Psychology Drugs Politics Source Type: news

Top San Diego Pain Clinic, Sorrento Valley Pain Relief, Now Offering...
Sorrento Valley Pain Relief, one of the top pain management clinics in San Diego, is now offering Botox injections for migraine relief. In addition to the variety of other migraine therapies offered,...(PRWeb December 16, 2014)Read the full story at http://www.prweb.com/releases/migraine-specialist/san-diego-ca/prweb12398275.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - December 16, 2014 Category: Pharmaceuticals Source Type: news

Vestibular Migraine in an Otolaryngology Clinic: Prevalence, Associated Symptoms, and Prophylactic Medication Effectiveness
ConclusionVM is a common disorder presenting in a dizziness clinic, and detailed history taking is important to assess VM-associated symptoms and thus to prevent underdiagnosis. The latter is very important because our study shows that the majority of patients, regardless of VM subtype, can benefit from a prophylactic treatment, but further prospective studies are necessary. (Source: Otology and Neurotology)
Source: Otology and Neurotology - December 16, 2014 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Dizziness is More Prevalent than Autophony Among Patients Who Have Undergone Repair of Superior Canal Dehiscence
ConclusionDizziness is more prevalent than autophony among patients who have undergone SCD repair, although the majority of these patients are satisfied with their decision to undergo surgery. Female sex and migraine headaches are associated with dizziness in this patient population. Further work is necessary to determine causal relationships among these associations. (Source: Otology and Neurotology)
Source: Otology and Neurotology - December 16, 2014 Category: ENT & OMF Tags: Vestibular Disorders Source Type: research

Postinfectious Opsoclonus‐Myoclonus Syndrome in a 41‐Year‐Old Patient—Visualizing Hyperactivation in Deep Cerebellar Nuclei by Cerebral [18F]‐FDG‐ PET
ABSTRACT A 41‐year‐old woman presented with acute onset headache, vertigo, nausea, and gait disorder, initially interpreted as a common cold. Within 2 weeks, she developed a severe opsoclonus‐myoclonus syndrome with truncal ataxia. Cerebrospinal fluid examination and serological findings suggested a recent infection with Coxsackie B3 virus. [18F]‐FDG‐PET proved to be the only imaging tool to identify the underlying pathology depicting hyperactivation in the vestibulo‐ and spinocerebellum as well as hyperactivation of the ocular muscles. At the clinical follow‐up 4 months later, the patient's symptoms were con...
Source: Journal of Neuroimaging - December 16, 2014 Category: Radiology Authors: Mona Mustafa, Johannes Levin, Florian Schöberl, Axel Rominger Tags: Case Report Source Type: research

Incidental Diagnosis of Cerebral Cortical Venous Thrombosis in Postdural Puncture Headache on Brain Computed Tomography
We describe 2 cases of patients with asymptomatic cortical vein thrombosis in the context of PDPH. In both cases, brain computed tomography (CT) scans showed an isolated cortical vein thrombosis without cerebral damage. Neurological examination revealed the typical orthostatic feature of PDPH, independently of cortical vein thrombosis which was considered as a radiological incidental finding. Clinical and radiological signs resolved after bed rest, oral caffeine, and anticoagulation therapy. Asymptomatic cortical vein thrombosis may be found on radiological exploration, even basic like brain CT scan without contrast, of PD...
Source: Journal of Neuroimaging - December 16, 2014 Category: Radiology Authors: Lisa Humbertjean, Xavier Ducrocq, Jean‐Christophe Lacour, Gioia Mione, Sébastien Richard Tags: Case Report Source Type: research

Cortical spreading depression decreases Fos expression in rat periaqueductal gray matter
Publication date: 12 January 2015 Source:Neuroscience Letters, Volume 585 Author(s): Volodymyr Borysovych Bogdanov , Olena Viktorivna Bogdanova , Arnaud Lombard , Virginie Chauvel , Sylvie Multon , Larysa Ivanivna Kot , Mykola Yukhymovych Makarchuk , Jean Schoenen The migraine headache involves activation and central sensitization of the trigeminovascular pain pathway. The migraine aura is likely due to cortical spreading depression (CSD), a propagating wave of brief neuronal depolarization followed by prolonged inhibition. The precise link between CSD and headache remains controversial. Our objectives were to study the ...
Source: Neuroscience Letters - December 16, 2014 Category: Neuroscience Source Type: research

Carotid-Cavernous Fistula as a Complication of Facial Trauma: A Case Report
Cranial Maxillofac Trauma ReconstructionDOI: 10.1055/s-0034-1396524Posttraumatic carotid-cavernous fistula is a very rare complication that can occur in patients with craniomaxillofacial trauma. Symptoms involve headache, diplopia, ptosis of the upper lid, conjunctival chemosis, pulsating exophthalmos, and ophthalmoplegia. Diagnosis can be challenging because various pathologic entities can present with similar symptoms such as superior orbital fissure syndrome, orbital apex syndrome, retrobulbar hematoma, and cavernous sinus syndrome. However, accurate and early diagnosis is of utmost importance because treatment delay ma...
Source: Craniomaxillofacial Trauma and Reconstruction - December 16, 2014 Category: ENT & OMF Authors: Lazaridou, MariaBourlidou, EleniKontos, KonstantinosMangoudi, Doxa Tags: Case Report Source Type: research

Ledipasvir-Sofosbuvir: Interferon-/Ribavirin-Free Regimen for Chronic Hepatitis C Virus Infection.
CONCLUSIONS: Ledipasvir-sofosbuvir is the first interferon- and ribavirin-free FDC agent that has SVR rates much greater than 94%, with minimal ADEs, for the treatment of chronic HCV genotype 1 in naïve and treatment-experienced patients. PMID: 25515863 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - December 16, 2014 Category: Drugs & Pharmacology Authors: Smith MA, Chan J, Mohammad RA Tags: Ann Pharmacother Source Type: research

Accompanying Symptoms Overlap during Attacks in Menière’s Disease and Vestibular Migraine
Jose Antonio Lopez-Escamez, Julia Dlugaiczyk, Julien Jacobs, Thomas Lempert, Roberto Teggi, Michael von Brevern and Alexandre Bisdorff (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - December 15, 2014 Category: Neurology Source Type: research

No Link Between Migraine, Breast Cancer Risk, Study Says
Title: No Link Between Migraine, Breast Cancer Risk, Study SaysCategory: Health NewsCreated: 12/12/2014 12:00:00 AMLast Editorial Review: 12/15/2014 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - December 15, 2014 Category: Cancer & Oncology Source Type: news

Chronic constipation‐associated symptoms in Asians and non‐Asians, and effects of 12‐week prucalopride treatment: A pooled analysis of 4 randomized, placebo‐controlled trials
ConclusionsPrucalopride 2 mg/day was found to be well‐tolerated and efficacious in relieving all chronic constipation‐associated symptoms in both Asians and non‐Asians, except for abdominal pain in Asians, over 12 weeks, regardless of their severity. (Source: Journal of Digestive Diseases)
Source: Journal of Digestive Diseases - December 15, 2014 Category: Gastroenterology Authors: Suck Chei Choi, Duowu Zou, Mei Yun Ke, Somchai Leelakusolvong, Jan Tack, Eamonn M M Quigley, Andy Liu, JinYong Kim Tags: Original Article Source Type: research