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A Sleep Gene Has A Surprising Role In Migraines
Mutations on a single gene appear to increase the risk for both an unusual sleep disorder and migraines, a team reports in Science Translational Medicine. The finding could help explain the links between sleep problems and migraines. It also should make it easier to find new drugs to treat migraines, researchers say. via A Sleep […]
Source: Biosingularity - May 9, 2013 Category: Medical Scientists Authors: Derya Tags: Biotechnology Source Type: blogs

Intravenous Dihydroergotamine Therapy for Pediatric Abdominal Migraines
Abdominal migraines present with debilitating symptoms in adolescence. At our institution, the gastroenterology, neurology, and autonomic departments collaborated in treating patients with such presentations. This case series describes 6 patients who were given intravenous dihydroergotamine (DHE) for presumed abdominal migraines. DHE was only used when other agents like amitriptyline, verapamil, topiramate, or depakote had proved ineffective. DHE was started at 0.5 mg dose and on average 7 to 9 mg were given on each hospitalization. Patient ages ranged from 13 to 19 years with the majority being female. One patient did not...
Source: Clinical Pediatrics - September 10, 2013 Category: Pediatrics Authors: Raina, M., Chelimsky, G., Chelimsky, T. Tags: Articles Source Type: research

An Exploratory Study to Determine the Relationship between Cervical Dysfunction and Perimenstrual Migraines.
CONCLUSION: The results suggest that an association between cervical dysfunction and perimenstrual headaches should be further explored. PMID: 25931651 [PubMed]
Source: Physiotherapy Canada - May 3, 2015 Category: Physiotherapy Authors: Horwitz S, Stewart A Tags: Physiother Can Source Type: research

Migraines, plantar fasciitis, joint pain, heartburn . . . gone
Elizabeth shared her emerging experience of health and life transformation by adopting the Wheat Belly lifestyle: “I am 34 years old, married with no kids. I suffered from hypertension, heart problems, plantar fasciitis, joint pains, heartburn, migraines and I was overweight. “After 60 days of wheat-free lifestyle, I feel so much better. I look better and I have never been so active! So far, I have shed 15 lbs, went down two dress sizes and lost 3 inches around my waist. I might have to do some shopping for smaller clothes! “More importantly, I feel lighter, I can walk miles and climb steps without pain. ...
Source: Wheat Belly Blog - October 18, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories gluten grains heartburn hypertension joint pain migraine plantar fasciitis Source Type: blogs

Complicated Migraines
Migraines are a common paroxysmal disorder that may present with a multitude of neurologic symptoms. Migraines have been re-categorized in the most recent edition of the International Classification of Headache Disorders (ICHD 3 beta). In this article, we review the literature on hemiplegic migraines, alternating hemiplegia of childhood, migraine with brainstem aura, retinal migraine, ophthalmoplegic migraine, Alice in Wonderland syndrome, and acute confusional migraine. We also discuss the principal clinical features, diagnostic criteria, and treatment options for these disorders.
Source: Seminars in Pediatric Neurology - January 21, 2016 Category: Neurology Authors: Alyssa E. Blumenfeld, M. Cristina Victorio, Frank R. Berenson Source Type: research

A Sleep Gene Has A Surprising Role In Migraines
Mutations on a single gene appear to increase the risk for both an unusual sleep disorder and migraines, a team reports in Science Translational Medicine. The finding could help explain the links between sleep problems and migraines. It also should make it easier to find new drugs to treat migraines, researchers say. via A Sleep […]
Source: Biosingularity - May 9, 2013 Category: Research Authors: Derya Tags: Biotechnology Source Type: blogs

Complicated Migraines
Migraines are a common paroxysmal disorder that may present with a multitude of neurologic symptoms. Migraines have been re-categorized in the most recent edition of the International Classification of Headache Disorders. In this article, we review the literature on hemiplegic migraines, alternating hemiplegia of childhood, migraine with brainstem aura, retinal migraine, ophthalmoplegic migraine, Alice in Wonderland syndrome, and acute confusional migraine. We also discuss the principal clinical features, diagnostic criteria, and treatment options for these disorders.
Source: Seminars in Pediatric Neurology - January 20, 2016 Category: Neurology Authors: Alyssa E. Blumenfeld, M. Cristina Victorio, Frank R. Berenson Source Type: research

Susceptible genes of restless legs syndrome in migraine
Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.
Source: Cephalalgia - October 6, 2016 Category: Neurology Authors: Fuh, J.-L., Chung, M.-Y., Yao, S.-C., Chen, P.-K., Liao, Y.-C., Hsu, C.-L., Wang, P.-J., Wang, Y.-F., Chen, S.-P., Fann, C. S.-J., Kao, L.-S., Wang, S.-J. Tags: Original Articles Source Type: research

Tyrosine Phosphorylation of NR2B Contributes to Chronic Migraines via Increased Expression of CGRP in Rats.
Abstract Tyrosine phosphorylation of NR2B (NR2B-pTyr), a subunit of the N-methyl-D-aspartate (NMDA) receptor, has been reported to develop central sensitization and persistent pain in the spine, but its effect in chronic migraines has not been examined. We hypothesized that tyrosine phosphorylation of NR2B contributes to chronic migraines (CM) through calcitonin gene-related peptide (CGRP) in rats. Ninety-four male Sprague-Dawley rats were subjected to seven inflammatory soup (IS) injections. In a subset of animals, the time course and location of NR2B tyrosine phosphorylation were detected by western blot and imm...
Source: Biomed Res - April 12, 2017 Category: Research Authors: Liang X, Wang S, Qin G, Xie J, Tan G, Zhou J, McBride DW, Chen L Tags: Biomed Res Int Source Type: research

CGRP: A new era for migraine treatment
Migraine is a common medical condition, affecting as many as 37 million people in the US. It is considered a systemic illness, not just a headache. Recent research has demonstrated that changes may begin to occur in the brain as long as 24 hours before migraine symptoms begin. Many patients have a severe throbbing headache, often on only one side of the head. Some people are nauseated with vomiting. Many are light sensitive (photophobic) and sound sensitive (phonophobic), and these symptoms can persist after the pain goes away. There are a variety of migraine subtypes with symptoms that include weakness, numbness, visual c...
Source: Harvard Health Blog - March 5, 2018 Category: Consumer Health News Authors: Carolyn A. Bernstein, MD, FAHS Tags: Drugs and Supplements Headache Health Migraines Pain Management Source Type: blogs

Could Estrogen Play a Role in Men ' s Migraines?
WEDNESDAY, June 27, 2018 -- Many women with migraines have headaches triggered by hormonal fluctuations. Now a small study hints that estrogen could play a role in men ' s migraines, too. The study of 39 men found that those with migraines had higher...
Source: Drugs.com - Daily MedNews - June 27, 2018 Category: General Medicine Source Type: news

Pharmacotherapy for acute migraines in children and adolescents.
Authors: Barbanti P, Grazzi L, Egeo G Abstract INTRODUCTION: Migraine is increasingly recognized as an extremely burdensome and disabling disorder in both children and adolescents. A proper treatment plan is needed to improve the quality of life of both children and families as well as to minimize the risk of disease progression. Areas covered: This review focuses on the current pharmacotherapy for acute migraine in pediatric populations, taking into account specific considerations for those drugs tested in randomized, placebo-controlled trials (RCTs). Expert opinion: A large number of RCTs have documented the effi...
Source: Expert Opinion on Pharmacotherapy - December 13, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Geographical Differences in Trigger Factors of Tension-Type Headaches and Migraines
In conclusion, the geographical location factor has an influence on the trigger factors of headaches. Ethnicity may have an effect due to the cultural differences. Change in weather and sunlight are important commonly identified trigger factors for headaches. Moreover, gender differences in some trigger factors are present among the patients with headaches, especially sunlight and sleep deprivation. More research studies can be conducted to have a better understanding on trigger factors in the future. This will enable proper identification of trigger factors, leading to a decrease in the number of headache episodes and an ...
Source: Current Pain and Headache Reports - February 21, 2019 Category: Neurology Source Type: research

5E.1. Associations between the Gut Microbiome and Migraines in 7-18-Year-Old Children: The American Gut Cohort Analysis
10% children suffer from migraine which result in more school absences and lower academic performance. Recent literature proposed that the gut microbiome may impact migraines through increased intestinal epithelial permeability and inflammation. This quantitative study examined the associations between the gut microbiome and migraines among a cohort of children aged 7-18 years from the American Gut Project (AGP). Findings can help understand biological mechanisms of migraines so that personalized interventions can be designed towards migraine control.
Source: Pain Management Nursing - March 31, 2019 Category: Nursing Authors: Jinbing Bai Source Type: research

5 Common Questions about Migraines
Treatment TermsChronic Headaches Author Morgan deBlecourt Overview Migraines are more than just bad headaches, and they ’re more common than most people think. Here, Timothy Collins, MD, a headache specialist at Duke, answers five common questions about migraines. Content Blocks CTA ButtonChronic Headaches and Migraines CTA Header Find Out More About Hero Imageblog_migraine_1932x862.jpg Preview Image Featured Doctors and Providers Timothy A. Collins, MD Related Doctors HeadingFeatured DoctorDisplay in Announcement Section:  Reviewer Timothy Collins Archived Medically Reviewed DateWednesday, January...
Source: dukehealth.org: Duke Health News - January 7, 2020 Category: Consumer Health News Authors: md141 at duke.edu Source Type: news