Glandular Fever (infectious mononucleosis) This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest news and research items in this category.

Red fingers syndrome in a patient with pseudolymphoma
To the Editor: A 31-year-old woman presented with a 10-year history of erythematous plaques on the face consistent with cutaneous pseudolymphoma. She incidentally was noted to also have dusky discoloration of her distal fingers and hypothenar eminences bilaterally (), but not toes, and without associated pain, numbness, or accentuation in the cold. Onycholysis was noted on several fingernails, but clubbing or periungual telangiectasias were not present. The patient related that the redness was not present at birth and appeared during her adult years before her pseudolymphoma lesions. She also noted that the redness appeare...
Source: Journal of the American Academy of Dermatology - May 24, 2013 Category: Dermatology Authors: Barry Ladizinski, Elise A. Olsen Tags: JAAD Online Source Type: research

Should tennis be worried about the 'kissing disease'?
Nicknamed the "kissing disease," mononucleosis or glandular fever is a viral illness that can linger for weeks, months or even years. CNN investigates its prevalence within the sport of tennis. (Source: CNN.com - Health)
Source: CNN.com - Health - May 20, 2013 Category: Consumer Health News Source Type: news

MHC II tetramers visualize human CD4+ T cell responses to Epstein-Barr virus infection and demonstrate atypical kinetics of the nuclear antigen EBNA1 response
We present evidence from an in vitro system that may explain these unusual kinetics. Unlike other EBNAs and lytic cycle proteins, EBNA1 is not naturally released from EBV-infected cells as a source of antigen for CD4+ T cell priming. (Source: The Journal of Experimental Medicine)
Source: The Journal of Experimental Medicine - May 6, 2013 Category: Internal Medicine Authors: Long, H. M., Chagoury, O. L., Leese, A. M., Ryan, G. B., James, E., Morton, L. T., Abbott, R. J. M., Sabbah, S., Kwok, W., Rickinson, A. B. Tags: Articles Source Type: research

Incidence of Rash After Amoxicillin Treatment in Children With Infectious Mononucleosis
Antibiotics-induced rash in Epstein-Barr virus acute infectious mononucleosis, especially the aminopenicillins-induced type, was first described during the 1960s, with a reported incidence of 80% to 100%. This phenomenon was not further investigated but is well-established in pediatric textbooks. The main observation of this study is that rash induced by amoxicillin in confirmed Epstein-Barr virus acute infectious mononucleosis was found at a rate of ~30%, which is much lower than previously reported. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - May 1, 2013 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Incidence of Rash After Amoxicillin Treatment in Children With Infectious Mononucleosis
CONCLUSIONS: The incidence of rash in pediatric patients with AIM after treatment with the current oral aminopenicillin (amoxicillin) is much lower than originally reported. (Source: PEDIATRICS)
Source: PEDIATRICS - May 1, 2013 Category: Pediatrics Authors: Chovel-Sella, A., Ben Tov, A., Lahav, E., Mor, O., Rudich, H., Paret, G., Reif, S. Tags: Allergy & Dermatology Article Source Type: research

Frequent Mutations in SH2D1A (XLP) in Males Presenting With High‐Grade Mature B‐Cell Neoplasms
Abstract X‐linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B‐cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnosed among 158 males presenting with B NHL (approximately 3.2%). Four of the patients had two episodes of B NHL and one had a single episode of B NHL followed by aggressive infectious mononucleosis. Prospective screening for XLP in males with B‐cell lymphoma at the time of initial diagnosis should...
Source: Pediatric Blood and Cancer - April 17, 2013 Category: Cancer & Oncology Authors: J.T. Sandlund, S.A. Shurtleff, M. Onciu, E. Horwitz, W. Leung, V. Howard, R. Rencher, M.E. Conley Tags: Brief Report Source Type: research

Is EBV a Common Cause of Elevated Liver Enzymes?
Discussion Infectious mononucleosis is caused by an Epstein-Barr Virus (EBV) infection causing the triad of fever, sore throat and adenopathy. The differential diagnosis of clinical presentations similar to EBV includes: Viral Cytomegalovirus Herpes simplex Hepatitis A, B, C HIV Varicella Bacterial/Spirochete Brucellosis Leptospirosis Syphilis Q fever Miscellaneous Autoimmune hepatitis Drug side effects Ischemia Wilson Disease Treatment for EBV infections is mainly supportive. Anti-viral medications such as ganciclovir are usually used for severe problems. Liver failure has been treated by transplant. Refraining fr...
Source: PediatricEducation.org - March 31, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Clinically severe Epstein-Barr virus encephalitis with mild cerebrospinal fluid abnormalities in an immunocompetent adolescent: a case report
Abstract: A 15-year-old boy developed Epstein-Barr virus (EBV) encephalitis, a rare complication of infectious mononucleosis. The severe clinical picture and the marked neuroimaging changes were in contrast with mild cerebrospinal fluid abnormalities: leukocyte count was normal and protein level was only slightly elevated. EBV DNA was detected in cerebrospinal fluid by polymerase chain reaction. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - March 26, 2013 Category: Microbiology Authors: Ilka Engelmann, Hala Nasser, Soufien Belmiloudi, Rémi Le Guern, Anny Dewilde, Louis Vallée, Didier Hober Tags: Case Reports Source Type: research

Hemophagocytic Lymphohistiocytosis--A Diagnostic Dilemma: Two Cases and Review
Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory disorder characterized by activation and proliferation of lymphocytes and histiocytes with cytokine release and uncontrolled hemophagocytosis, especially late in the course of the disease. Clinical features include relapsing fevers, hepatosplenomegaly, cytopenias, lymphadenopathy, and coagulopathy. The diagnosis can be challenging, as the early signs and symptoms are nonspecific and no specific laboratory tests exist. This syndrome is frequently not recognized and has a significant mortality rate. Typical scenarios in which HLH should be considered include m...
Source: Clinical Pediatrics - March 26, 2013 Category: Pediatrics Authors: Bhasin, A., Tolan, R. W. Tags: Articles Source Type: research

Infectious Mononucleosis: Still a 'Kissing Disease'Infectious Mononucleosis: Still a 'Kissing Disease'
Paul G. Auwaerter, MD, describes new research that sheds additional light on the old problem of EBV infection and infectious mononucleosis. Medscape Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 20, 2013 Category: Consumer Health News Tags: Infectious Diseases Commentary Source Type: news

Parvovirus B19 Mimicking Epstein-Barr Virus Infectious Mononucleosis in an Adult
Epstein-Barr virus is the cause of classic infectious mononucleosis. Other infections may mimic Epstein-Barr virus infectious mononucleosis, for example, cytomegalovirus, human herpes virus-6, toxoplasmosis, lymphoma, cat scratch fever, and rubella. Parvovirus B19 infections in children present as febrile exanthems; adults usually have small joint arthritis. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 15, 2013 Category: Journals (General) Authors: Sigridh Muñoz-Gómez, Burke A. Cunha Tags: Clinical communications to the editor Source Type: research

Sex ratio of infectious mononucleosis and possible relevance to multiple sclerosis
Infectious mononucleosis (IM) is associated with the risk of developing multiple sclerosis (MS). Using databases of hospital admissions for England (1999–2005), we investigated the female-to-male ratios (FMRs) for admission to hospital for IM and MS stratified by age. Males were more frequently admitted for IM for all age groups apart from ages 10–14 (FMR 1.50; 95% confidence interval (CI) 1.36–1.64) and, borderline significantly, at ages 15–19 (FMR 1.03, 95% CI 0.99–1.08). This intriguing aspect of IM epidemiology in adolescence, the atypical female excess, may be linked to the sex ratio of M...
Source: Multiple Sclerosis - February 20, 2013 Category: Neurology Authors: Ramagopalan, S. V., Giovannoni, G., Yeates, D. G., Seagroatt, V., Goldacre, M. J. Tags: Short Reports Source Type: research

Challenging the use of the absolute lymphocyte count in the diagnosis of infectious mononucleosis by analysis of a large cohort of monospot test results
(Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - February 19, 2013 Category: ENT & OMF Authors: Lennon P., Fenton J.E., O'Neill J.P., O'Dwyer T.P. Tags: Correspondence: Letters Source Type: research

The impact of serological features in Chinese children with primary or past Epstein--Barr virus infections
Conclusions: Infants aged 9 years had serological evidence of EBV infection, whereas IM peaked in patients aged 2--3 years. (Source: Virology Journal)
Source: Virology Journal - February 13, 2013 Category: Virology Authors: Yuan HuangCong WeiKun ZhengDongchi Zhao Source Type: research

Acyclovir Reduces the Duration of Fever in Patients with Infectious Mononucleosis-like Illness.
Abstract Acyclovir is known for its antiviral activity against some pathogenic viruses such as the Epstein-Barr virus (EBV) that causes infectious mononucleosis (IM) and IM-like illness. Therefore, we empirically administered acyclovir to patients with suspected EBV-IM and IM like-illness, upon their admission to our hospital. We admitted 25 patients, who were hospitalized for fever and lymphadenopathy, to the Tohoku University Hospital Infectious Disease Ward. As part of treatment, 8 of these patients were given acyclovir (750 mg/day) with their consent and were assigned to the acyclovir group; the remaining 17 pa...
Source: The Tohoku Journal of Experimental Medicine - February 4, 2013 Category: Research Authors: Usami O, Saitoh H, Ashino Y, Hattori T Tags: Tohoku J Exp Med Source Type: research

Cytokine profiles in children with primary Epstein–Barr virus infection
Abstract Primary Epstein–Barr virus (EBV) infection causes infectious mononucleosis and hemophagocytic lymphohistiocytosis (HLH) in children, where EBV infects B and CD8+ T cells, respectively. We measured pro‐inflammatory and anti‐inflammatory cytokines in both diseases. Significantly higher concentrations of various mediators, including interferon‐γ, neopterin, interleukin (IL)‐6, IL‐10, IL‐18, and heme oxygenase‐1, were observed in EBV‐HLH. Because of their similarity to the profile of familial HLH, this profile was likely a consequence of HLH, but not ectopic infection. TNF‐α levels were elevated ...
Source: Pediatric Blood and Cancer - February 4, 2013 Category: Cancer & Oncology Authors: Taizo Wada, Masahiro Muraoka, Tadafumi Yokoyama, Tomoko Toma, Hirokazu Kanegane, Akihiro Yachie Tags: Brief Report Source Type: research

[Stevens-Johnson syndrome concurrent with primary Epstein-Barr virus infection].
We report a case of Stevens-Johnson syndrome concurrent with EBV infection. CASE REPORT: A 17-year-old boy consulted for an eruption suggestive of Stevens-Johnson syndrome, which was supported by the histopathology results. The patient had taken no medication during the previous weeks. Laboratory examinations showed atypical activated T lymphocytes. Serological tests and PCR results confirmed the diagnosis of primary EBV infection. The outcome was spontaneously favorable with only symptomatic treatment being required. DISCUSSION: Stevens-Johnson syndrome is characterized by "target" lesions and profuse mucous membr...
Source: Annales de Dermatologie et de Cenereologie - February 1, 2013 Category: Dermatology Authors: Brunet-Possenti F, Steff M, Marinho E, Crickx B, Descamps V Tags: Ann Dermatol Venereol Source Type: research

Use of complement regulators, CD35, CD46, CD55, and CD59, on leukocytes as markers for diagnosis of viral and bacterial infections.
Abstract Several complement regulatory proteins exist on self-cells to prevent damage by the serum complement system. In the present study, we aimed to perform quantitative analysis of membrane-bound complement regulators, CR1 (CD35), MCP (CD46), DAF (CD55), and MIRL (CD59), on peripheral blood neutrophils, monocytes, and lymphocytes from healthy controls (n = 36) and febrile patients diagnosed with either bacterial (n = 21) or viral (n = 26) infections. Our results show that: a) increased CD35 and CD55 levels on neutrophils and monocytes present potent markers of bacterial infection, b) increased expression of CD4...
Source: Human Immunology - January 29, 2013 Category: Allergy & Immunology Authors: Nuutila J, Jalava-Karvinen P, Hohenthal U, Kotilainen P, Pelliniemi TT, Nikoskelainen J, Lilius EM Tags: Hum Immunol Source Type: research

Epstein–Barr Virus Infection and Posttransplant Lymphoproliferative Disorder
Epstein–Barr virus (EBV) is an important pathogen in recipients of solid organ transplants (SOT). Infection with EBV manifests as a spectrum of diseases/malignancies ranging from asymptomatic viremia through infectious mononucleosis to posttransplant lymphoproliferative disorder (PTLD). EBV disease and its associated PTLD is more frequently seen when primary EBV infection occurs after transplant, a common scenario in pediatric SOT recipients. Intensity of immunosuppressive therapies also influences the risk for PTLD. The use of EBV viral load monitoring facilitates the diagnosis and management of EBV/PTLD as well as bein...
Source: American Journal of Transplantation - January 24, 2013 Category: Transplant Surgery Authors: M. Green, M. G. Michaels Tags: Continuing Medical Education Source Type: research

Characterization of Epstein–Barr virus reactivation in a modeled spaceflight system
Abstract Epstein–Barr virus (EBV) is the causative agent of mononucleosis and is also associated with several malignancies, including Burkitt's lymphoma, Hodgkin's lymphoma, and nasopharyngeal carcinoma, among others. EBV reactivates during spaceflight, with EBV shedding in saliva increasing to levels ten times those observed pre‐and post‐flight. Although stress has been shown to increase reactivation of EBV, other factors such as radiation and microgravity have been hypothesized to contribute to reactivation in space. We used a modeled spaceflight environment to evaluate the influence of radiation and microgravity o...
Source: Journal of Cellular Biochemistry - January 22, 2013 Category: Biochemistry Authors: Alaina A. Brinley, Corey A. Theriot, Mayra Nelman‐Gonzalez, Brian Crucian, Raymond P. Stowe, Alan D.T. Barrett, Duane L. Pierson Tags: Article Source Type: research

Infectious mononucleosis mimicking malignant T-cell lymphoma in the nasopharynx: a case report and review of the literature.
In this report, we described a patient of IM with atypical T-cell proliferation in the nasopharynx. In-situ hybridization for EBV-encoded RNA with immunostaining against CD20 was used for evaluation of EBV infection. The histopathologic features of IM could mimic malignant T-cell lymphoma. It should be differentiate reactive T-cell lymphoproliferation from malignant lymphoma in the nasopharynx. PMID: 23236550 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - January 14, 2013 Category: Pathology Authors: He HL, Wang MC, Huang WT Tags: Int J Clin Exp Pathol Source Type: research

A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
by Rohina Rubicz, Robert Yolken, Eugene Drigalenko, Melanie A. Carless, Thomas D. Dyer, Lara Bauman, Phillip E. Melton, Jack W. Kent, John B. Harley, Joanne E. Curran, Matthew P. Johnson, Shelley A. Cole, Laura Almasy, Eric K. Moses, Nikhil V. Dhurandhar, Ellen Kraig, John Blangero, Charles T. Leach, Harald H. H. Göring Infection with Epstein-Barr virus (EBV) is highly prevalent worldwide, and it has been associated with infectious mononucleosis and severe diseases including Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal lymphoma, and lymphoproliferative disorders. Although EBV has been the focus of extensive res...
Source: PLoS Genetics - January 10, 2013 Category: Genetics & Stem Cells Authors: Rohina Rubicz et al. Source Type: research

Epstein–barr virus associated acute hepatitis with cross‐reacting antibodies to other herpes viruses in immunocompetent patients: Report of two cases
Abstract Epstein–Barr virus (EBV) is the causative agent of infectious mononucleosis (IM) which is characterized by the triad of fever, sore throat, and lymphadenopathy. Self‐limited, mild liver function test abnormalities are seen in IM. Acute hepatitis in primary EBV infection is uncommon. Serum transaminases are elevated but are less than fivefold the normal levels in most cases and rarely exceed 10 times the normal levels in primary EBV infections especially in elderly. Laboratory diagnosis of acute EBV infection is by serological assays confirming the presence of EBV viral capsid antigen (VCA) IgM antibodies. Due ...
Source: Journal of Medical Virology - January 7, 2013 Category: Virology Authors: Ekta Gupta, Vikram Bhatia, Aashish Choudhary, Archana Rastogi, Naveen L. Gupta Tags: Research Article Source Type: research

LMP1 promoter sequence analysis in Epstein Barr virus pediatric infection reveals preferential circulation of B95.8 related variants in Argentina.
Abstract The Epstein Barr virus (EBV) is associated with several lymphoid and epithelial malignancies such as Hodgkin and Burkitt lymphoma or nasopharyngeal carcinoma and it is also the etiological agent of infectious mononucleosis (IM). Transcriptional regulation of the viral oncoprotein LMP1, remains yet not fully understood. LMP1 expression can be initiated in an EBNA2 dependent or independent manner from ED-L1 or LT-R1 promoters. It has been proposed that sequence variation at ED-L1 region could be an important factor concerning LMP1 expression. In order to characterize the natural sequence variation of the ED-...
Source: Infection, Genetics and Evolution - January 7, 2013 Category: Genetics & Stem Cells Authors: Magdalena G, Alejandro LM, Jaime A, Elena DM, Guillermo M, Samanta M, Andrea CP, Victoria PM Tags: Infect Genet Evol Source Type: research

Two medical pioneers aim to trial a cancer-killing virus. I aim to help out | Alexander Masters
A pair of researchers in Sweden may have a revolutionary cancer treatment on their hands. But a separate revolution will be needed to get it to marketJust north of Stockholm, among the creaking Swedish ice-forests, three revolutions for 2013 are taking place.Revolution One: Two researchers at the University of Uppsala have engineered a virus that will attack cancer. Cheap, precise, with only mild, flu-like side-effects, this plucky little microbe sounds too good to be true. Yet in peer-reviewed articles in top journals, Professor Magnus Essand and Dr Justyna Leja have repeatedly showed that Ad5[CgA-E1A-miR122]PTD views hea...
Source: Guardian Unlimited Science - January 4, 2013 Category: Science Authors: Alexander Masters Tags: Comment The Guardian Crowdsourcing Health Medical research Society Technology Kickstarter Features Cancer Internet Science Comment is free Source Type: news

A comparative study of flow cytometric T cell receptor Vβ repertoire and T cell receptor gene rearrangement in the diagnosis of large granular lymphocytic lymphoproliferation
ConclusionsFC‐Vβ analysis was slightly more sensitive than TCR‐GR for the detection of clonal T cell lymphoproliferation. However, we must interpret the laboratory findings with clinical context as clonal T cell lymphoproliferation may occur in patients with viral infection. (Source: Clinical and Laboratory Haematology)
Source: Clinical and Laboratory Haematology - January 3, 2013 Category: Hematology Authors: Y.‐C. Hsieh, S.‐T. Chang, W.‐T. Huang, S.‐Y. Kuo, T.‐A. Chiang, S.‐S. Chuang Tags: Original Article Source Type: research

A comparative study of flow cytometric T cell receptor Vβ repertoire and T cell receptor gene rearrangement in the diagnosis of large granular lymphocytic lymphoproliferation.
CONCLUSIONS: FC-Vβ analysis was slightly more sensitive than TCR-GR for the detection of clonal T cell lymphoproliferation. However, we must interpret the laboratory findings with clinical context as clonal T cell lymphoproliferation may occur in patients with viral infection. PMID: 23286298 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 3, 2013 Category: Hematology Authors: Hsieh YC, Chang ST, Huang WT, Kuo SY, Chiang TA, Chuang SS Tags: Int J Lab Hematol Source Type: research

Infectious Mononucleosis (Mono)
"Infectious Mononucleosis," or, "mono," is many times referred to as the, "kissing disease." The virus that causes mono is transmitted through a person's saliva and people can get it through kissing, although people can also be exposed to the virus through a sneeze or a cough, or by sharing a food utensil or a glass with someone who has the virus. Mono is not as contagious as some kinds of infections fortunately, such as the common cold. (Source: Disabled World)
Source: Disabled World - January 2, 2013 Category: Disability Tags: Influenza Colds and Flu Source Type: news

Leigh Syndrome in a Girl With a Novel DLD Mutation Causing E3 Deficiency
We present the biochemical and molecular diagnosis of dihydrolipoamide dehydrogenase deficiency (also known as E3 deficiency) and Leigh syndrome in a 14-year-old girl with learning disability and episodic encephalopathy and ketoacidosis. The diagnosis was based on values of plasma amino acids and urine organic acids, obtained during acute encephalopathy, lactic ketoacidosis, and liver failure, precipitated by infectious mononucleosis. Enzymatic and molecular analyses confirmed dihydrolipoamide dehydrogenase deficiency. E3 activity from cultured skin fibroblasts ranged from 9-29% of the mean. Molecular analysis revealed com...
Source: Pediatric Neurology - January 1, 2013 Category: Neurology Authors: Shane C. Quinonez, Steven M. Leber, Donna M. Martin, Jess G. Thoene, Jirair K. Bedoyan Tags: Case Reports Source Type: research

Finally well after a full abdominal at 31 – Nina’s Story
Like many girls, I started my periods at 11, but quickly realised that mine where different to others. The pain and blood loss where much higher than I could really cope with and still function. There is a history down my mothers and grandmothers side, that this is how it has always been for ‘us girls’, so I tried to put up as best I could. By 15 I needed something to help and went to my doctor, he prescribed the pill for me, but my mother didn’t want me to take it. It wasn’t till much later she and I would understand why. From 17 to 26 I became a testing ground for all doctors and sexual health doc...
Source: The Hysterectomy Association - December 31, 2012 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Heavy Bleeding Latest News Your Stories heavy periods hysterectomy Source Type: news

Expatriates ill after travel:results from the Geosentinel Surveillance Network
Conclusions: Ill returned expatriates differ from other travelers in travel characteristics and proportionate morbidity for specific diseases, based on the region of exposure and travel reason. They are more likely to present with more serious illness. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - December 31, 2012 Category: Infectious Diseases Authors: Poh-Lian LimPauline HanLin ChenSusan MacDonaldPrativa PandeyDeVon HalePatricia SchlagenhaufLouis LoutanAnnelies Wilder-SmithXiaohong DavisDavid Freedman Source Type: research

Agranulocytosis after infectious mononucleosis
We report the case of a 5-year-old boy with agranulocytosis after infectious mononucleosis (IM). Antibodies against anti-human neutrophil-specific antigens (HNA)-1 were detected in his serum. A literature review on agranulocytosis after IM and our case suggest that anti-HNA-1 antibodies play important roles in agranulocytosis associated with IM. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - December 26, 2012 Category: Virology Authors: Tadafumi Yokoyama, Yuko Tokuhisa, Akiko Toga, Toshihiro Fujiki, Yasuhisa Sakakibara, Shintaro Mase, Raita Araki, Ryosei Nishimura, Taizo Wada, Tetsuya Fuseda, Eiji Kato, Akihiro Yachie Tags: Case report Source Type: research

Clinicopathologic spectrum and EBV status of post-transplant lymphoproliferative disorders after allogeneic hematopoietic stem cell transplantation.
We describe clinicopathologic features of 17 cases of PTLD after allogeneic hematopoietic stem cell transplantation (allo-HSCT), which were analyzed by in situ hybridization for EBV and a panel of antibodies directed against numerous antigens, including CD20, PAX5, CD3, bcl-6, CD10, MUM-1/IRF4, CD138, Kappa, Lambda, CD30, CD15, and Ki67. The cases included 13 males and 4 females with a median age of 31 years (range 9-49 years) and the PTLDs developed 1.5-19 months post-transplant (mean 4.7 months). The histological types indicated five cases of early lesions, two of plasmacytic hyperplasia and three of infectious monon...
Source: International Journal of Hematology - December 20, 2012 Category: Hematology Authors: Chen DB, Song QJ, Chen YX, Chen YH, Shen DH Tags: Int J Hematol Source Type: research

Orkney's world-record MS rates – Vikings to blame?
Conclusion This was a well-conducted study which carried out a thorough review of medical and laboratory records to verify each diagnosis of MS, and used internationally accepted criteria to establish the prevalence of MS (although prevalence rates for the study did vary according to different diagnostic criteria). However, as the authors point out, most patients were not reviewed in person by the study team, so it is possible there were some inaccuracies. In particular, a number of older people who were diagnosed with MS before the widespread introduction of MRI scans to help diagnose the disease more accurately, may hav...
Source: NHS News Feed - December 11, 2012 Category: Consumer Health News Tags: Neurology Source Type: news

Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells.
Abstract Epstein Barr virus (EBV) is carried by almost all adults, mostly without clinical manifestations. Latent virus infection of B lymphocytes induces activation and proliferation that can be demonstrated in vitro. In healthy individuals, generation of EBV induced malignant proliferation is avoided by continuous immunological surveillance. The proliferation inducing set of the virally encoded genes is expressed exclusively in B cells in a defined differentiation window. It comprises nine EBV encoded nuclear proteins, EBNA 1-6, and three cell membrane associated proteins, LMP-1, 2A and 2B, designated as latency ...
Source: Journal of Immunological Methods - November 30, 2012 Category: Allergy & Immunology Authors: Rasul AE, Nagy N, Sohlberg E, Ádori M, Claesson HE, Klein G, Klein E Tags: J Immunol Methods Source Type: research

Detection Of Early Markers Of Epstein Barr Virus; The Diagnostic Value
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection. The benefits of this diagnostic approach in patients with mononucleosis and in EBV-infected transplant patients are evaluated in an article published in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2012 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Is the detection of early markers of Epstein Barr virus of diagnostic value?
Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 16, 2012 Category: Science Source Type: news

Brain on Fire: My Month of Madness [Excerpt]
In 2009 Susannah Cahalan was a healthy 24-year-old reporter at the New York Post , one of the country's oldest newspapers, when she suddenly developed a range of worrying symptoms. Her left hand went numb, paranoid thoughts obsessed her mind, and migraines and stomachaches beset her body. Initially diagnosed with mononucleosis, Cahalan continued to grow worse, eventually suffering a series of near-fatal seizures, psychosis, and a gradual loss of brain function. She ended up at New York University's Langone Medical Center, where a team of doctors, lead by neurologist Souhel Najjar, diagnosed her with a disease that ...
Source: Scientific American - Official RSS Feed - November 16, 2012 Category: Science Tags: Mind & Brain,Mind Brain,Psychology,Neurological Disorders,Neuroscience,Biology Source Type: research

Is the detection of early markers of Epstein Barr virus of diagnostic value?
(Mary Ann Liebert, Inc./Genetic Engineering News) Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 16, 2012 Category: Global & Universal Source Type: news

Ultrasound in Athletes: Emerging Techniques in Point-of-Care Practice.
Ultrasound in Athletes: Emerging Techniques in Point-of-Care Practice. Curr Sports Med Rep. 2012 Nov;11(6):298-303 Authors: Yim ES, Corrado G Abstract Ultrasound offers sports medicine clinicians the potential to diagnose, treat, and manage a broad spectrum of conditions afflicting athletes. This review article highlights applications of ultrasound that hold promise as point-of-care diagnostics and therapeutic tools that can be used directly by clinicians to direct real-time management of athletes. Point-of-care ultrasound has been examined most in the context of musculoskeletal disorders in athletes, with ...
Source: Current Sports Medicine Reports - November 1, 2012 Category: Sports Medicine Authors: Yim ES, Corrado G Tags: Curr Sports Med Rep Source Type: research

Corticosteroids as standalone or add-on treatment for sore throat.
CONCLUSIONS: Oral or intramuscular corticosteroids, in addition to antibiotics, increase the likelihood of both resolution and improvement of pain in participants with sore throat. Further trials assessing corticosteroids in the absence of antibiotics and in children are warranted. PMID: 23076943 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 31, 2012 Category: Journals (General) Authors: Hayward G, Thompson MJ, Perera R, Glasziou PP, Del Mar CB, Heneghan CJ Tags: Cochrane Database Syst Rev Source Type: research

Profile of EBV Associated Infectious Mononucleosis.
Abstract During a 5 year period, 33 children (22 males) were diagnosed to have infectious mononucleosis (M:F::2:1; age 9 mo-15 y). The common clinical features observed were fever (100%), lymphadenopathy (84%) hepatosplenomegaly (81%), tonsillar enlargement (45%), neck swelling (30%), upper respiratory symptoms (21%), epitrochlear node enlargement (20%), vomiting and diarrhea (1%). Ten children had complications; upper airway obstruction and hemophagocytic lymphohistocytosis occurred in four each and septic shock in two. EBV associated infectious mononucleosis in hospitalized children was found to affect mainly pre...
Source: Indian Pediatrics - October 8, 2012 Category: Pediatrics Authors: Balasubramanian S, Ganesh R, Kumar JR Tags: Indian Pediatr Source Type: research

Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy.
In conclusion, the plasma levels of Gal-9 may be predictive of a severe inflammation status during the acute phase of HIV-1 infection and could be a potential biomarker during acute infection. PMID: 23038209 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 7, 2012 Category: Research Authors: Saitoh H, Ashino Y, Chagan-Yasutan H, Niki T, Hirashima M, Hattori T Tags: Tohoku J Exp Med Source Type: research

Infectious mononucleosis and risk of breast cancer in a prospective study of women
Conclusion Results of this large prospective study do not support a clear association between history of clinical IM and risk of invasive breast cancer. Content Type Journal ArticleCategory Original PaperPages 1-6DOI 10.1007/s10552-012-0064-1Authors J. Massa, Department of Nutrition, Harvard School of Public Health, 655 Huntington, Ave, Boston, MA 02115, USAA. Hamdan, Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USAK. C. Simon, Department of Nutrition, Harvard School of Public Health, 655 Huntington, Ave, Boston, MA 02115, USAK. Bertr...
Source: Cancer Causes and Control - October 6, 2012 Category: Cancer & Oncology Tags: Cancer Causes and Control Source Type: research

About Epstein-Barr virus-associated infectious mononucleosis
Although the Epstein-Barr virus causes most illnesses presenting as mononucleosis, clinicians should be able to recognize and consider alternate differential possibilities. (Source: Modern Medicine Contemporary Pediatrics)
Source: Modern Medicine Contemporary Pediatrics - October 1, 2012 Category: Pediatrics Source Type: news

EBV primary infection in childhood and its relation to B‐cell lymphoma development: A mini‐review from a developing region
Abstract In most underdeveloped countries the initial contact with Epstein Barr virus (EBV) usually happens in the first decade of life and results in an asymptomatic infection, while in developed areas primary infection in adolescence or adulthood is accompanied by infectious mononucleosis in 50% cases. Although it is generally a harmless passenger, in some individuals, it is associated with B‐cell lymphoma. In Argentina, EBV primary infection shows the classical pattern observed in developing populations, given that nearly 70% of patients are seropositive by the age of 2 years. However, EBV association with paediatric ...
Source: International Journal of Cancer - September 24, 2012 Category: Cancer & Oncology Authors: Paola A Chabay, Maria V Preciado Tags: Mini Review Source Type: research

Characterization of Epstein‐Barr virus reactivation in a modeled spaceflight system
Abstract Epstein‐Barr virus (EBV) is the causative agent of mononucleosis and is also associated with several malignancies, including Burkitt's lymphoma, Hodgkin's lymphoma, and nasopharyngeal carcinoma, among others. EBV reactivates during spaceflight, with EBV shedding in saliva increasing to levels ten times those observed pre‐and post‐flight. Although stress has been shown to increase reactivation of EBV, other factors such as radiation and microgravity have been hypothesized to contribute to reactivation in space. We used a modeled spaceflight environment to evaluate the influence of radiation and microgravity o...
Source: Journal of Cellular Biochemistry - September 18, 2012 Category: Biochemistry Authors: Alaina A. Brinley, Corey A. Theriot, Mayra Nelman‐Gonzalez, Brian Crucian, Raymond P. Stowe, Alan D. T. Barrett, Duane L. Pierson Tags: Article Source Type: research

Updates in immunoassays: virology.
Abstract Virus identification is a challenge to the clinical microbiologist since growing viruses in traditional cell culture is labor intensive, time consuming, and subject to contamination. The advent of rapid and automated immunoassays has eliminated this problem by generating positive results in minutes to hours. For example, testing for infectious mononucleosis can yield a positive result in 3-8 minutes as seen with the Beckman Coulter, Inc. ICON Mono test or in 5-15 minutes with the MONO Mononucleosis Rapid Test Device marketed by ACON Laboratories, Inc. Fully automated immunoassay analyzers provide fast, acc...
Source: Clinical Laboratory Science : Journal of the American Society for Medical Technology - September 15, 2012 Category: Laboratory Medicine Authors: Josko D Tags: Clin Lab Sci Source Type: research

Resveratrol inhibits Epstein Barr Virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets.
In this study, we examined the antiviral activity of RV against the EBV replicative cycle and investigated the molecular targets possibly involved. In a cellular context that allows in vitro EBV activation and lytic cycle progression through mechanisms closely resembling those that in vivo initiate and enable productive infection, we found that RV inhibited EBV lytic genes expression and the production of viral particles in a dose-dependent manner. We demonstrated that RV inhibited protein synthesis, decreased reactive oxygen species (ROS) levels, and suppressed the EBV-induced activation of the redox-sensitive transcripti...
Source: Antiviral Research - September 15, 2012 Category: Virology Authors: Alessandra DL, Giuseppe A, Egidio L, Giorgio O, Francesca C, Elena M Tags: Antiviral Res Source Type: research