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Mononucleosis and Epstein-Barr: What's the connection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein-Barr virus sometimes causes mononucleosis, but most Epstein-Barr infections are less severe. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - November 13, 2009 Category: Consumer Health News Source Type: news

Mononucleosis and Epstein-Barr: What's the connection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein-Barr virus sometimes causes mononucleosis, but most Epstein-Barr infections are less severe. Sponsored by:Chemotherapy.com - http://www.chemotherapy.com (Source: MayoClinic.com Full Feed)
Source: MayoClinic.com Full Feed - November 12, 2009 Category: Consumer Health News Source Type: news

Valacyclovir Pharmacokinetics and Exploratory Pharmacodynamics in Young Adults With Epstein-Barr Virus Infectious Mononucleosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study are to characterize the pharmacokinetics and explore the pharmacodynamics of acyclovir in plasma and oral washings of 8 subjects receiving 7 days of valacyclovir 1500 mg twice daily for EBV infectious mononucleosis. Virologic and clinical responses are assessed over 12 days. Acyclovir is measured by liquid chromatography/ultraviolet detection. EBV DNA is quantitated by TaqMan polymerase chain reaction. NONMEM VI and linear regression are used for data analysis. Acyclovir profiles in plasma and oral washings are consistent with a 1-compartment model. Final model estimates of clearance, volume of...
Source: The Journal of Clinical Pharmacology - November 6, 2009 Category: Drugs & Pharmacology Authors: Vezina HE, Balfour HH, Weller DR, Anderson BJ, Brundage R Tags: J Clin Pharmacol Source Type: journals

Genitourinary manifestations of Epstein-Barr virus infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews the available literature and data regarding EBV in the female genital tract and discusses areas of consensus and controversy. The primary manifestation of EBV seems to be vulvar ulcers, which are underrecognized. Diagnosis relies on appropriate serologic testing. Management includes local care and may require pain and corticosteroid medications. Although EBV is present elsewhere in the female genital tract, its pathogenic role in the cervix, uterus, fallopian tubes, and ovaries is poorly understood. Content Type Journal ArticleDOI 10.1007/s11908-009-0065-8Authors Randi LeighPaul Nyirjesy, Drex...
Source: Current Infectious Disease Reports - November 5, 2009 Category: Infectious Diseases Tags: Current Infectious Disease Reports Source Type: journals

False positive immunoglobulin m antibody to cytomegalovirus in child with infectious mononucleosis caused by epstein-barr virus infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 16-month-old boy was admitted because of cough that had lasted for 10 days. The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus (CMV). On the basis of seroconversion to Epstein-Barr nuclear antigen (EBNA) Ig G positivity and reduced CMV Ig M titer with persistently negative CMV Ig G, a definite diagnosis of EBV-induced infectious mononucleosis was established 1 year 2 month later. PMID: 19881978 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - October 31, 2009 Category: Universities & Medical Training Authors: Park JM, Shin JI, Lee JS, Jang YH, Kim SH, Lee KH, Lee CH Tags: Yonsei Med J Source Type: journals

Case 34-2009 -- A 20-Year-Old Man with Sore Throat, Fever, and RashEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 20-year-old man was admitted to this hospital because of sore throat, fever, and a diffuse rash for 1 week. Testing for streptococcal pharyngitis and mononucleosis was negative. Amoxicillin and clavulanate were prescribed, and the next day, a red, itchy rash developed on the medial surface of his right arm; the lesions became raised, enlarged, and painful and spread from his arms to his legs, back, hands, feet, and perioral area, without mucosal involvement. Examination disclosed a diffuse eruption of tender violaceous-pink papulovesicles, which progressed to hemorrhagic crusting. A diagnostic procedure was performed. (S...
Source: New England Journal of Medicine - October 28, 2009 Category: Internal Medicine Authors: Taylor, C. R., Gandhi, R. T., Handwerker, J., Duncan, L. M. Tags: CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL Source Type: journals

Got Bad Breath? Try Chlorophyll for HalitosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) Forget about breath mints. You can never take enough to cover halitosis if your breath really smells bad. The only real way to get rid of bad breath is to solve the problem internally.Fortunately, there's an easy way to do that: Chlorophyll. It's Mother Nature's amazing green cleaning machine, and the more you take, the cleaner you get.Here, we bring you a collection of supporting quotes about chlorophyll and halitosis (bad breath) from some of the best-known natural health authors in the industry. You'll learn not only why chlorophyll works so well, but also the best sources for getting some.Of course, if yo...
Source: NaturalNews.com - October 16, 2009 Category: Consumer Health Advice Source Type: news

What Is Glandular Fever? What Causes Glandular Fever? What Is Infectious Mononucleosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glandular fever is a type of viral infection. It is also known as infectious mononucleosis. It can cause fever, sore throat, fatigue, swollen lymph nodes and glands. It is caused by the Epstein-Barr virus (EBV). It is one of the most common viruses that can affect humans. Most EBV infections occur during early childhood. They usually produce few or no symptoms. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 14, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Antiviral drug found to cut the severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers say. Instead, the disease can be treated to shorten the duration of the illness and reduce the chance of... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - October 3, 2009 Category: American Health Source Type: news

Clinically controlled study on children’s infectious mononucleosis treated by Chinese medicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion  Using Chinese herbs for clearing heat, removing toxin, activating blood circulation, and dissolving stasis is effective and safe for the treatment of CIM. It can effectively improve the clinical symptoms and shows a certain effect on immune regulation. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s11655-009-0347-xAuthors Yuan Yao, Beijing Children’s Hospital Affiliated to Capital Medical University Beijing 100045 ChinaHong-mei Duan, Beijing University of Chinese Medicine School of Nursing Beijing 100102 ChinaHui-min Yan, Beijing Children’s Hospital Affiliated to Capit...
Source: Chinese Journal of Integrative Medicine - October 3, 2009 Category: Internal Medicine Tags: Chinese Journal of Integrative Medicine Source Type: journals

Antiviral drug found to reduce severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers say. Instead, the disease can be treated to shorten the duration of the illness and reduce the chance of... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - October 1, 2009 Category: American Health Source Type: news

MononucleosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - September 28, 2009 Category: Journals (General) Source Type: info

Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from toll-like receptor 3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein-Barr virus–encoded small RNA (EBER) is nonpolyadenylated, noncoding RNA that forms stem-loop structure by intermolecular base-pairing, giving rise to double-stranded RNA (dsRNA)–like molecules, and exists abundantly in EBV-infected cells. Here, we report that EBER induces signaling from the Toll-like receptor 3 (TLR3), which is a sensor of viral double-stranded RNA (dsRNA) and induces type I IFN and proinflammatory cytokines. A substantial amount of EBER, which was sufficient to induce signaling from TLR3, was released from EBV-infected cells, and the majority of the released EBER existed as a complex w...
Source: The Journal of Experimental Medicine - September 27, 2009 Category: Internal Medicine Authors: Iwakiri, D., Zhou, L., Samanta, M., Matsumoto, M., Ebihara, T., Seya, T., Imai, S., Fujieda, M., Kawa, K., Takada, K. Tags: Brief Definitive Reports Source Type: journals

Medical news: Study offers hope for mono treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mononucleosis, the curse of high school and college students, does not have to bring social and academic lives to a screeching halt, researchers reported this week. Instead, the disease can be treated to shorten its duration and reduce the chance of... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - September 22, 2009 Category: American Health Source Type: news

Epstein-Barr virus BZLF1 gene promoter variants in pediatric patients with acute infectious mononucleosis: Its comparison with pediatric lymphomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein-Barr virus genotypes can be distinguished by polymorphic variations in the genes encoding EBNA2, 3A, 3B, and 3C. The immediate early gene BZLF1 plays a key role in modulating the switch from latency to lytic replication and therefore enabling viral propagation. The aim of this study was to investigate and compare BZLF1 promoter sequence (Zp) variation in pediatric infectious mononucleosis (IM) and in pediatric EBV positive lymphoma biopsies. Zp was sequenced from peripheral blood mononuclear cells (PBMC) and throat swabs from 10 patients with IM at the time of diagnosis (D0) and during convalescence; and from 13 ly...
Source: Journal of Medical Virology - September 21, 2009 Category: Virology Authors: Mario Alejandro Lorenzetti, Marina Inés Gutiérrez, Jaime Altcheh, Guillermo Moscatelli, Samanta Moroni, Paola Andrea Chabay, María Victoria Preciado Tags: Research Article Source Type: journals

Antiviral drug found to reduce severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The so-called kissing disease is commonly treated only with rest. But in a study, young people who received an antiviral medication early in the illness became less sick. Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers say. Instead, the disease can be treated to shorten the duration of the illness and reduce the chance of transmission. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - September 21, 2009 Category: Science Source Type: news

Antiviral drug found to reduce severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The so-called kissing disease is commonly treated only with rest. But in a study, young people who received an antiviral medication early in the illness became less sick. Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers say. Instead, the disease can be treated to shorten the duration of the illness and reduce the chance of transmission. (Source: L.A. Times - Health)
Source: L.A. Times - Health - September 18, 2009 Category: Consumer Health News Source Type: news

Study offers hope for mono treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mononucleosis, the curse of high school and college students, does not have to bring social and academic lives to a screeching halt, researchers reported this week. Instead, the disease can be treated to shorten its duration and reduce the chance of... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - September 15, 2009 Category: American Health Source Type: news

Antiviral drug found to reduce severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The so-called kissing disease is commonly treated only with rest. But in a study, young people who received an antiviral medication early in the illness became less sick. Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers reported today. Instead, the disease can be treated to shorten the duration of the illness and reduce the chance of transmission. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - September 14, 2009 Category: Science Source Type: news

Antiviral drug found to reduce severity of monoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mononucleosis, the curse of high school and college students, doesn't have to bring social and academic lives to a screeching halt, researchers reported today. Instead, the disease can be treated to shorten the duration of the illness and reduce the... (Source: OrlandoSentinel: Medical Research)
Source: OrlandoSentinel: Medical Research - September 14, 2009 Category: American Health Source Type: news

Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settle [Recent advances in clinical practice]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risk of lymphoproliferative disorders (LDs) has become a major concern for clinicians managing patients with inflammatory bowel disease (IBD). Yet it is difficult to distinguish the possible responsibility of immunosuppressive therapy from the background risk due to the inflammatory disorder itself. LDs are clonal B or T cell proliferation showing considerable heterogeneity and the incidence has increased since the 1970s. The strongest and best-established risk factors for LDs are primary and acquired immunodeficiency (HIV, immunosuppressant), notably via defective immune surveillance of Epstein–Barr virus. In ma...
Source: Gut - September 11, 2009 Category: Gastroenterology Authors: Sokol, H, Beaugerie, L Tags: GUT Recent advances in clinical practice Source Type: journals

The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deletion or mutation of the SH2D1A gene located at Xq25 is responsible for the development of the X-linked lymphoproliferative disease, XLP. Primary infection of the affected individuals with EBV leads to fulminant and often fatal infectious mononucleosis, FIM. Moreover, they run a 200 fold elevated risk for lymphoma development. Due to the critical role of the immune response for the outcome of EBV infection and the detection of EBV genomes in several malignancies, XLP studies have been mainly focused on the immunological aspects. The involvement of SAP in the apoptotic machinery provides a further aspect in the compl...
Source: Cell Cycle - September 11, 2009 Category: Cytology Authors: Nagy N, Matskova L, Hellman U, Klein G, Klein E Tags: Cell Cycle Source Type: journals

[Recent advances in clinical practice] Inflammatory bowel disease and lymphoproliferative disorders: the dust is starting to settleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The risk of lymphoproliferative disorders (LDs) has become a major concern for clinicians managing patients with inflammatory bowel disease (IBD). Yet it is difficult to distinguish the possible responsibility of immunosuppressive therapy from the background risk due to the inflammatory disorder itself. LDs are clonal B or T cell proliferation showing considerable heterogeneity and the incidence has increased since the 1970s. The strongest and best-established risk factors for LDs are primary and acquired immunodeficiency (HIV, immunosuppressant), notably via defective immune surveillance of Epstein–Barr virus. In ma...
Source: Gut - September 10, 2009 Category: Gastroenterology Authors: Sokol, H, Beaugerie, L Tags: GUT Recent advances in clinical practice Source Type: journals

[From tonsillitis to coxitis. A case report.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a 19-year-old woman with a throat infection, increased temperature, a positive mononucleosis monospot test and clinical signs of a lower respiratory tract infection. The diagnosis was thought to be mononucleosis complicated by bacterial pneumonia, but she was later found to have Fusobacterium necrophorum in blood cultures. She subsequently developed metastatic abscesses in her lungs and hip joint and was diagnosed with Lemierre's Syndrome. This case report highlights the importance of close links between clinicians and microbiologists in order to prevent morbidity and mortality in patients with an infectious dis...
Source: Tidsskrift for den Norske Laegeforening - September 9, 2009 Category: Journals (General) Authors: Sarjomaa M, Liyanarachi KV, Brekke H Tags: Tidsskr Nor Laegeforen Source Type: journals

The Role of Valacyclovir on Epstein–Barr Virus Viral Loads in Pediatric Liver Transplantation PatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this small, non–placebo-controlled study, valacyclovir treatment was not effective to decrease peripheral blood EBV viral loads. (Source: Transplantation Proceedings)
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: F. Özçay, H. Arslan, B. Bilezikçi, Ş. Sevmiş, G. Moray, M. Haberal Tags: Liver Transplantation Source Type: journals

Posttransplant Lymphoproliferative Disease in Pediatric Liver Transplant RecipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Posttransplant lymphoproliferative disease was first reported in 1968. Posttransplant lymphoproliferative disease encompasses a range of abnormalities from benign infectious mononucleosis-like illnesses to non-Hodgkin's lymphomas with nodal and extranodal site involvement. We evaluated five children who had posttransplant lymphoproliferative disease after liver transplantation. Since 2001, we have performed 118 liver transplantations in 115 children. Five children (4.6%), including three girls and two boys of overall mean age, 3.9 year, developed posttransplant lymphoproliferative diseases. The indications for li...
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: S. Sevmis, S. Pehlivan, R. Shabazov, H. Karakayali, F. Ozcay, M. Haberal Tags: Liver Transplantation Source Type: journals

Infectious MononucleosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Infectious MononucleosisCategory: Diseases and ConditionsCreated: 12/31/1997Last Editorial Review: 8/24/2009 (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - August 24, 2009 Category: Pediatrics Source Type: consumer

Clinical values of multiple Epstein-Barr virus (EBV) serological biomarkers detected by xMAP technologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Combined EBV serological biomarkers could improve the diagnostic values for NPC. Diverse EBV serological spectrums presented in populations with different EBV-associated diseases, but NPC patients have the highesr EBV activity. (Source: BioMed Central)
Source: BioMed Central - August 22, 2009 Category: Journals (General) Authors: Ai-Di GuLi-Xia LuYan-Bo XieLi-Zhen ChenQi-Sheng FengTiebang KangWei-Hua JiaYi-Xin Zeng Source Type: journals

A case of sulphasalazine-induced DRESS syndrome with delayed acute interstitial nephritisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the case of a 77-year-old female with sulphasalazine-induced DRESS syndrome who improved rapidly on corticosteroid treatment. After prednisone withdrawal, the patient developed renal failure that necessitated a session of haemodialysis. A kidney biopsy showed acute tubulointerstitial nephritis with an intense lymphocytic infiltrate and tubular necrosis. Kidney function normalized after a further 2 weeks of corticosteroid treatment. This is the first histologically proven case of acute tubulointerstitial nephritis in the setting of sulphasalazine-induced DRESS syndrome. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - August 16, 2009 Category: Urology & Nephrology Authors: Augusto, J.-F., Sayegh, J., Simon, A., Croue, A., Chennebault, J.-M., Cousin, M., Subra, J.-F. Tags: Exceptional Case Source Type: journals

Glutamate dehydrogenase activity in lymphocytes of B-cell chronic lymphocytic leukaemia patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The increased GLDH activity is specific for the PBMC of B-CLL patients. The GLUD1 but not the GLUD2 gene expression pattern is different between the PBMC of IM and B-CLL patients. PMID: 19683518 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - August 12, 2009 Category: Biochemistry Authors: Pajič T, Cernelč P, Briški AS, Lejko-Zupanc T, Malešič I Tags: Clin Biochem Source Type: journals

Airway compromise in infectious mononucleosis: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 25-year-old Caucasian man had difficulty swallowing and shortness of breath during an episode of infectious mononucleosis. His tonsils were "kissing" and erythematous but no superimposed infection with a streptococcal organism was identified. His symptoms improved rapidly upon administration of intravenous steroids. This case demonstrates a rare and short-term complication that is well described in young adults with infectious mononucleosis. Physicians should routinely counsel their patients with infectious mononucleosis to be aware of potentially life-threatening airway obstruction in addition to splenic rupture and men...
Source: Cases Journal - August 2, 2009 Category: Journals (General) Source Type: journals

Sennetsu neorickettsiosis: a probable fish-borne cause of fever rediscovered in Laos.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neorickettsia sennetsu has been described from Japan and Malaysia, causing a largely forgotten infectious mononucleosis-like disease. Because it is believed to be contracted from eating raw fish, frequently consumed in the Lao PDR, we looked for evidence of N. sennetsu among Lao patients and fish. A buffy coat from 1 of 91 patients with undifferentiated fever was positive by 16S rRNA amplification and sequencing and real-time polymerase chain reactions (PCR) targeting two N. sennetsu genes. Lao blood donors and patients with fever, hepatitis, or jaundice (N = 1,132) had a high prevalence (17%) of immunofluorescence ass...
Source: The American Journal of Tropical Medicine and Hygiene - July 30, 2009 Category: Tropical Medicine Authors: Newton PN, Rolain JM, Rasachak B, Mayxay M, Vathanatham K, Seng P, Phetsouvanh R, Thammavong T, Zahidi J, Suputtamongkol Y, Syhavong B, Raoult D Tags: Am J Trop Med Hyg Source Type: journals

Sunbeds dramatically raise cancer riskEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report was published in June and we are considering the recommendations in full." Government sources said action was "very likely".Kathy Banks, chief executive of the Sunbed Association, said it disputed IARC's reclassification of sunbeds as carcinogenic.She said: "There is no proven link between the responsible use of sunbeds and skin cancer. The relationship between UV exposure and an increased risk of developing skin cancer is only likely to arise where over-exposure – that is, burning – has taken place."This outcome would be the same whether burning takes place on a sunbed or on a beach or in a park or garden ...
Source: Guardian Unlimited Science - July 28, 2009 Category: Science Authors: Denis Campbell Tags: Cancer Medical research Health policy Science Skin cancer (melanoma) Life and style Politics UK news Society & wellbeing The Guardian Source Type: news

Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A liquid chromatographic method for the simultaneous analysis of marker pteridins and biopterin reduced forms, in urine samples is proposed. A Zorbax Eclipse XDB-C18 column was used for the chromatographic separation, using a 98/2 (v/v), citrate buffer (pH 5.5)-acetonitrile mobile phase, in isocratic mode. A post-column photoderivatization was carried out with an on-line photoreactor, located between a diode array detector (DAD) and a fast scanning fluorescence detector (FSFD). Neopterin (NEO), biopterin (BIO), pterin (PT) and dihydrobiopterin (BH2) were determined by measuring native fluorescence, using the photoreact...
Source: Analytica Chimica Acta - July 23, 2009 Category: Chemistry Authors: Cañada-Cañada F, Espinosa-Mansilla A, Muñoz de la Peña A, Mancha de Llanos A Tags: Anal Chim Acta Source Type: journals

Lymphocytic vasculitis involving the central nervous system occurs in patients with X-linked lymphoproliferative disease in the absence of Epstein-Barr virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe two unrelated patients with fatal T-cell-mediated central nervous system vasculitis for whom repeated serologic and molecular testing for EBV was negative. In both patients, clonal T-cell populations were observed, but neither demonstrated evidence of lymphoma. Thus, loss of SAP function can lead to dysregulated immune responses characterized by the uncontrolled expansion and activation of T cells independent of EBV infection. Pediatr Blood Cancer. © 2009 Wiley-Liss, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - July 19, 2009 Category: Cancer & Oncology Authors: Kawsar R. Talaat, Jennifer A. Rothman, Jeffrey I. Cohen, Mariarita Santi, John K. Choi, Miguel Guzman, Robert Zimmerman, Sudha Nallasamy, Alexander Brucker, Martha Quezado, Stefania Pittaluga, Nicholas J. Patronas, Amy D. Klion, Kim E. Nichols Source Type: journals

"Mono" linked to chronic fatigue syndrome in teensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW YORK (Reuters Health) - Teens who develop "mono," otherwise known as infectious mononucleosis, may be at risk for chronic fatigue syndrome, according to a study in Pediatrics. (Source: Reuters: Health)
Source: Reuters: Health - July 15, 2009 Category: Consumer Health News Tags: healthNews Source Type: news

"Mono" Linked to Chronic Fatigue Syndrome in TeensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Teens who develop "mono," otherwise known as infectious mononucleosis, may be at risk for chronic fatigue syndrome, according to a study in Pediatrics. Source: Reuters Health Related MedlinePlus Topics: Chronic Fatigue Syndrome, Infectious Mononucleosis, Teen Health (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - July 15, 2009 Category: Consumer Health News Source Type: consumer

Infectious Mononucleosis May Increase Risk for Chronic Fatigue Syndrome in TeensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Female sex and greater fatigue severity, but not reported steroid use during infectious mononucleosis, were linked to the development of chronic fatigue syndrome in teens. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 10, 2009 Category: Consumer Health News Tags: Pediatrics Source Type: news

Acute lymphocytic crisis following herpes simplex type 1 virus hepatitis in a nonimmunocompromised man: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This case report shows that herpes simplex virus type 1 is a possible cause of an acute lymphocytic crisis similar to other well known infectious agents such as Epstein-Barr virus, cytomegalovirus, human immunodeficiency virus, human herpes virus type 6, adenovirus, toxoplasma and human T-cell lymphotropic virus. Furthermore, this case report expands the clinical spectrum of herpes simplex virus hepatitis, since it is reported in a nonimmunocompromised patient presenting with atypical acute lymphocytic syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 30, 2009 Category: Journals (General) Source Type: journals

The uptake and use of the Monospot test in patients with tonsillitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of the study was to ascertain the uptake of the Monospot test in St. James's hospital in Dublin over the five years 2002-2006 and to determine the percentage of Monospot tests which had a positive result. Using the HIPE, Electronic Patient Record (EPR) and Patient Access System (PAS) databases in St. James's Hospital, a cohort of 593 patients with a diagnosis of tonsillitis or infectious mononucleosis was identified. Fourteen patients met the exclusion criteria as outlined below leaving a valid pool of 579 patients. It was ascertained whether each patient had a Monospot performed and if so, whether the result...
Source: Ir Med J - June 30, 2009 Category: Journals (General) Authors: McCormack R, O'Shea T Tags: Ir Med J Source Type: journals

bioMérieux Launches VIDAS® EBV, a New Test for the Diagnosis of Infectious MononucleosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
bioMérieux, a world leader in the field of in vitro diagnostics, today launched VIDAS® EBV for the detection of the Epstein-Barr virus (EBV). This virus causes 80% of cases of infectious mononucleosis, which is often known as “the kissing disease” because it is transmitted through saliva. (Source: bioMerieux Press Releases)
Source: bioMerieux Press Releases - June 29, 2009 Category: Biotechnology Source Type: organizations

Chronic Fatigue Syndrome After Infectious Mononucleosis in AdolescentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Infectious mononucleosis may be a risk factor for chronic fatigue syndrome in adolescents. Female gender and greater fatigue severity, but not reported steroid use during the acute illness, were associated with the development of chronic fatigue syndrome in adolescents. Additional research is needed to determine other predictors of persistent fatigue after infectious mononucleosis. (Source: PEDIATRICS)
Source: PEDIATRICS - June 28, 2009 Category: Pediatrics Authors: Katz, B. Z., Shiraishi, Y., Mears, C. J., Binns, H. J., Taylor, R. Tags: Office Practice ARTICLES Source Type: journals

Increase of atypical lymphocytes expressing CD4+/CD45RO+ in an infectious mononucleosis-like syndrome associated with hepatitis A virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract  Subpopulations of regular and atypical lymphocytes in the peripheral blood of a 24-year-old man with an infectious mononucleosis (IM)-like syndrome associated with hepatitis A virus (HAV) infection were analyzed. The ratio of CD4+ to CD8+ cells was in the normal range (1.19 and 1.23 in the regular and atypical lymphocytes, respectively), with no increase in CD8+ cells. The percentage of CD8+/CD11b- cells was not increased in the atypical lymphocytes. However, CD45RO+ was expressed on 86.3% of CD4+ atypical lymphocytes. The present data suggest that atypical lymphocytes expressing CD4+/CD45RO+ may pl...
Source: Journal of Infection and Chemotherapy - June 25, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Cytomegalovirus and Epstein-Barr virus coinfection in three toddlers with prolonged illnessesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) usually cause primary and latent infections during childhood; thus, coinfection with these viruses occurs occasionally in children. However, its clinical impact has not been established, and may be underestimated. Three cases of coinfection involving these two viruses in toddlers are described: a 14-month-old male with infectious mononucleosis, an 18-month-old female with hemophagocytic lymphohistiocytosis, and a 13-month-old female with acute hepatitis. All three patients had prolonged illnesses. Serial serological testing and quantitation of viral DNA for CMV and EBV usi...
Source: Journal of Medical Virology - June 22, 2009 Category: Virology Authors: Yoshinori Ito, Yukiko Shibata-Watanabe, Jun-ichi Kawada, Koichi Maruyama, Hiroshi Yagasaki, Seiji Kojima, Hiroshi Kimura Tags: Research Article Source Type: journals

Epstein-Barr virus colonization of tonsillar and peripheral blood B-cell subsets in primary infection and persistenceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report 2 findings consistent with this latter view. First, we examined circulating non–isotype-switched (IgD+CD27+) memory cells, a population that much evidence suggests is GC-independent in origin. Whereas isotype-switched memory had the highest viral loads by quantitative polymerase chain reaction, EBV was detectable in the nonswitched memory pool both in infectious mononucleosis (IM) patients undergoing primary infection and in most long-term virus carriers. Second, we examined colonization by EBV of B-cell subsets sorted from a unique collection of IM tonsillar cell suspensions. Here viral loads were concentr...
Source: Blood - June 17, 2009 Category: Hematology Authors: Chaganti, S., Heath, E. M., Bergler, W., Kuo, M., Buettner, M., Niedobitek, G., Rickinson, A. B., Bell, A. I. Tags: Immunobiology Source Type: journals

Infliximab: Atypical infectious mononucleosis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 17, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Infliximab: Atypical infectious mononucleosis: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 19 (Source: Reactions Weekly)
Source: Reactions Weekly - June 15, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

The Overly Empathic White KnightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
<!--break-->Rescuer Subtypes: The Overly Empathic White KnightAfter reviewing the commonalities and differences among rescuers, we created four subtypes - the overly empathic white knight, the tarnished white knight, the terrorizing/terrified white knight, and the balanced rescuer. These subtypes are not discrete entities but represent our observation of clusters of characteristics that can overlap. In this blog, we will focus on the overly empathic white knight.The overly empathic white knight fears emotional distance. This fear can be triggered by many sources, such as separation, loss of love, or loss of approval....
Source: Psychology Today Addiction Center - June 10, 2009 Category: Addiction Authors: Mary C. Lamia, Ph.D. and Marilyn Krieger, Ph.D. Tags: Addiction Happiness Personality Relationships Self-Help codependency Source Type: consumer

Azathioprine: Fatal EBV mononucleosis, histiocystosis and B cell lymphoproliferative disorder: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 9, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Differential diagnosis of hepatitis E virus, cytomegalovirus and Epstein-Barr virus infection in patients with suspected hepatitis EEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Since infection by these herpesviruses may produce acute hepatitis, such event can cause diagnostic mistakes and should be investigated in patients positive for anti-HEV IgM and negative for HEV RNA. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - June 8, 2009 Category: Virology Authors: M. Fogeda, F. de Ory, A. Avellón, J.M. Echevarría Tags: Regular articles Source Type: journals