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Condition: Kidney Transplantation

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Total 40015 results found since Jan 2013.

PLGA+Fe ₃O₄+PFP Nanoparticles Drug-Delivery Demonstrates Potential Anti-Tumor Effects on Tumor Cells
CONCLUSIONS PLGA+Fe₃O₄+PFP nanoparticles were safe, with higher invasive ability and binding efficiency of targeting CDDP with tumor cells. Therefore, PLGA+Fe₃O₄+PFP nanoparticles demonstrated potential anti-tumor effects after transplantation.PMID:35145054 | DOI:10.12659/AOT.933246
Source: Annals of Transplantation - February 11, 2022 Category: Transplant Surgery Authors: Dayan Yang Qiqing Chen Min Zhang Lin Xie Yan Chen Tingting Zhong Fang Tian Guiying Feng Xiangxiang Jing Ling Lin Source Type: research

Gypenoside XLIX loaded nanoparticles targeting therapy for renal fibrosis and its mechanism
This study opens a promising way for targeted drug treatment of renal fibrosis.PMID:34529980 | DOI:10.1016/j.ejphar.2021.174501
Source: European Journal of Pharmacology - September 16, 2021 Category: Drugs & Pharmacology Authors: Qixia Liu Xiaohui Chen Min Kan Jing Yang Qian Gong Rui Jin Yulong Dai Juan Jin Hongmei Zang Source Type: research

H < sub > 2 < /sub > O < sub > 2 < /sub > -Activatable Antioxidant Polymeric Prodrug Nanoparticles for the Prevention of Renal Ischemia/Reperfusion Injury
In this study, we developed fucoidan-coated polymeric prodrug (Fu-PVU73) nanoparticles as renal IR-targeting nanotherapeutics that can rapidly eliminate H2O2 and exert anti-inflammatory and antiapoptotic effects. Fu-PVU73 nanoparticles were composed of H2O2-activatable antioxidant and anti-inflammatory polymeric prodrug (PVU73) that incorporated H2O2-responsive peroxalate linkages, ursodeoxycholic acid (UDCA), and vanillyl alcohol (VA) in its backbone. Fu-PVU73 nanoparticles rapidly scavenged H2O2 and released UDCA and VA during H2O2-triggered degradation. In the study of renal IR injury mouse models, Fu-PVU73 nanoparticle...
Source: Biomacromolecules - August 5, 2022 Category: Biochemistry Authors: Hyeonbin Shin Seungwon Jeong Yeongjong Lee Chanhee Jeon Gayoung Kwon Sooyeon Kim Dongwon Lee Source Type: research

In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green.
CONCLUSIONS: Taken together, these data indicate that poly(lactic-co-glycolic acid) nanoparticles may be used to label transplanted islets and may be imaged with in vivo MR and optical imaging systems. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. PMID: 23640738 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - May 2, 2013 Category: Radiology Authors: Hwang JH, Noh YW, Choi JH, Noh JR, Kim YH, Gang GT, Kim KS, Park HS, Lim YT, Moon H, Hong KS, Lee HG, Chung BH, Lee CH Tags: Magn Reson Med Source Type: research

In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green
ConclusionsTaken together, these data indicate that poly(lactic‐co‐glycolic acid) nanoparticles may be used to label transplanted islets and may be imaged with in vivo MR and optical imaging systems. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Source: Magnetic Resonance in Medicine - May 2, 2013 Category: Radiology Authors: Jung Hwan Hwang, Young‐Woock Noh, Jung‐Hyun Choi, Jung‐Ran Noh, Yong‐Hoon Kim, Gil‐Tae Gang, Kyoung‐Shim Kim, Hye Sun Park, Yong Taik Lim, Hyeyoung Moon, Kwan Soo Hong, Hee Gu Lee, Bong Hyun Chung, Chul‐Ho Lee Tags: Full Paper Source Type: research

Biological characteristics of adipose tissue-derived stem cells labeled with amine-surface-modified superparamagnetic iron oxide nanoparticles.
Abstract Cell labeling and tracking are becoming increasingly important areas within the field of stem cell transplantation. The ability to track the migration and distribution of implanted cells is critical to understanding the beneficial effects and mechanisms of stem cell therapy. The present study investigated the effects of amine-surface-modified superparamagnetic iron oxide (SPIO) nanoparticles on the biological properties of human adipose tissue-derived stem cells (hADSCs). Monodisperse hydrophobic magnetite (Fe3 O4 ) nanoparticles were prepared using silicon and surface-modified with amine coating. Cell vi...
Source: Cell Biology International - March 10, 2015 Category: Cytology Authors: Nan W, Jingyuan Z, Xin G, Yue D, Yang L, Xiang Z, Ren'an W, Yue D, Liang Z, Wei Z, Chao H, Lin S, Bo S, Yan L, Jing L Tags: Cell Biol Int Source Type: research

Engineered gold nanoparticles targeted to mesenchymal cells from BOS patients can be safely administered to normal mice by inhalation
Engineered gold nanoparticles targeted with a specific antibody (GNP-HCe) to primary lung mesenchymal cells (MC) isolated from BOS patients and loaded with everolimus were able to specifically inhibit MC proliferation and increase apoptosis without stimulating the inflammatory response (Cova, 2014). The aim of the present work was to prove that GNP-HCe can be safely administered to mice by inhalation.Nanoparticles (NPs) distribution and toxicity in vivo were assayed by aerosolization of 50 µg of labeled GNP-HCe or GNP-HC (gold nanoparticles with the antibody without everolimus) for 30 min a day for 2 weeks. Control m...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Cova, E., Ceccarelli, G., Pandolfi, L., Agozzino, M., Allevi, R., Benedetti, L., Colombo, M., Inghilleri, S., Magni, S., Oggionni, T., Prosperi, D., Cusella, M. G., Meloni, F. Tags: 8.2 Transplantation Source Type: research

Targeting inflammatory monocytes by immune-modifying nanoparticles prevents acute kidney allograft rejection
In this study, immune-modifying nanoparticles attenuated acute rejection in a fully MHC-mismatched murine model of kidney allograft rejection. Nanoparticles prevented monocyte accumulation within the graft and inhibited both innate and adaptive alloimmunity. Our experimental findings identify immune-modifying nanoparticles as a potential induction agent in kidney transplantation.
Source: Kidney International - July 15, 2022 Category: Urology & Nephrology Authors: Christina Lai, Steven Chadban, Yik Wen Loh, Tony Kwan, Chuanmin Wang, Julian Singer, Paula Niewold, Zheng Ling, Alanna Spiteri, Daniel Getts, Nicholas King, Huiling Wu Tags: basic research Source Type: research

Rat Kidneys Vitrified, Warmed with Magnetic Nanoparticles, then Transplanted Successfully
Another step forward for the magnetic nanoparticle approach to thawing vitrified tissues was recently reported. Vitrification for low-temperature storage is a fairly well established technique, at least for organs. The challenge lies in thawing vitrified organ tissue without causing so much damage that it becomes non-viable for transplantation. Researchers have now managed to make this work for rat kidneys, albeit just barely. The kidneys were damaged, and it remains the case that scaling up to human organs will have its challenges. A greater volume of tissue makes cryopreservation and later thawing much harder, but succes...
Source: Fight Aging! - June 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs