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Condition: Obesity

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Total 71740 results found since Jan 2013.

Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland, Brandee L. Branche, Lauren E. Howard, Robert J. Hamilton, William J. Aronson, Martha K. Terris, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research

Cytotoxicity Analysis of Morphologically Different Sol-Gel-Synthesized MgO Nanoparticles and Their In Vitro Insulin Resistance Reversal Ability in Adipose cells.
Abstract Insulin resistance is one of the major factors that leads to type 2 diabetes. Although insulin therapies have been shown to overcome insulin resistance, overweight and hypoglycemia are still observed in most cases. The disadvantages of insulin therapies have driven the interest in developing novel curative agents with enhanced insulin resistance reversibility. Magnesium deficiency has also been recognized as a common problem which leads to insulin resistance in both type 1 and 2 diabetes. Oxide nanoparticles demonstrate highly tunable physicochemical properties that can be exploited by engineers to develo...
Source: Applied Biochemistry and Biotechnology - November 26, 2019 Category: Biochemistry Authors: Jeevanandam J, Chan YS, Danquah MK, Law MC Tags: Appl Biochem Biotechnol Source Type: research

Biomaterials-based nanoparticles conjugated to regulatory T cells provide a modular system for localized delivery of pharmacotherapeutic agents
J Biomed Mater Res A. 2022 Sep 9. doi: 10.1002/jbm.a.37442. Online ahead of print.ABSTRACTType 1 diabetes (T1D) presents with two therapeutic challenges: the need to correct underlying autoimmunity and restore β-cell mass. We harnessed the unique capacity of regulatory T cells (Tregs) and the T cell receptor (TCR) to direct tolerance induction along with tissue-localized delivery of therapeutic agents to restore endogenous β-cell function. Specifically, we designed a combinatorial therapy involving biomaterials-based poly(lactic-co-glycolic acid) nanoparticles co-loaded with the Treg growth factor, IL-2, and the β-cell ...
Source: Biomed Res - September 9, 2022 Category: Research Authors: Gregory P Marshall Judit Cserny Chun-Wei Wang Benjamin Looney Amanda L Posgai Rhonda Bacher Benjamin Keselowsky Todd M Brusko Source Type: research

Molecules, Vol. 27, Pages 2795: Binary Effects of Gynostemma Gold Nanoparticles on Obesity and Inflammation via Downregulation of PPAR & gamma;/CEPB & alpha; and TNF- & alpha; Gene Expression
This study represents thorough research on the antiobesity effect of Gynostemma pentaphyllum gold nanoparticles synthesized using a green approach and the efficacy instead of related inflammatory responses.
Source: Molecules - April 27, 2022 Category: Chemistry Authors: Reshmi Akter Li Ling Esrat Jahan Rupa Jin KyuPark Ramya Mathiyalagan Jinnatun Nahar Lee Jong Won Kim Do Hyun Mohanapriya Murugesan Deok Chun Yang Se Chan Kang Gi-Young Kwak Tags: Article Source Type: research

Targeted nanoparticles with novel non-peptidic ligands for oral delivery.
Abstract Orally administered targeted nanoparticles have a large number of potential biomedical applications and display several putative advantages for oral drug delivery, such as the protection of fragile drugs or modification of drug pharmacokinetics. These advantages notwithstanding, oral drug delivery by nanoparticles remains challenging. The optimization of particle size and surface properties and targeting by ligand grafting have been shown to enhance nanoparticle transport across the intestinal epithelium. Here, different grafting strategies for non-peptidic ligands, e.g., peptidomimetics, lectin mimetics,...
Source: Advanced Drug Delivery Reviews - February 20, 2013 Category: Drugs & Pharmacology Authors: des Rieux A, Pourcelle V, Cani PD, Marchand-Brynaert J, Préat V Tags: Adv Drug Deliv Rev Source Type: research

Gold nanoparticles synthesized with Smilax glabra rhizome modulates the anti-obesity parameters in high-fat diet and streptozotocin induced obese diabetes rat model
Publication date: Available online 16 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): SiddiqueAkber Ansari, Ahmed Bari, Riaz Ullah, Maghimaa Mathanmohun, Vishnu Priya Veeraraghavan, Zhongwei SunAbstractDiabetes is a major emerging health consequence across the world which directly associated with the obesity. Contemporary anti-diabetic drugs have numeral limitations, and investigation of herbal remedies for diabetes give novel guide for the expansion of new drugs that can be used as harmonizing to present anti-diabetic allopathic medications. Gold nanoparticles (AuNPs) of 21 nm have be...
Source: Journal of Photochemistry and Photobiology B: Biology - October 17, 2019 Category: Speech-Language Pathology Source Type: research

Bilirubin Nanoparticles Reduce Diet-Induced Hepatic Steatosis, Improve Fat Utilization, and Increase Plasma β-Hydroxybutyrate
This study demonstrates that bilirubin nanoparticles induce hepatic fat utilization, raise plasma ketones, and reduce hepatic steatosis, opening new therapeutic avenues for NAFLD.
Source: Frontiers in Pharmacology - December 18, 2020 Category: Drugs & Pharmacology Source Type: research

Novel insights into the synergistic effects of selenium nanoparticles and metformin treatment of letrozole - induced polycystic ovarian syndrome: targeting PI3K/Akt signalling pathway, redox status and mitochondrial dysfunction in ovarian tissue
CONCLUSION: Combined SeNPs and MET therapy could be potential therapeutic agent for PCOS-IR model via modulation of the PI3K/Akt pathway, enhancing anti-inflammatory and anti-oxidant properties and altered mitochondrial functions.HighlightsThe strong relationship between obesity, insulin resistance, and polycystic ovarian syndrome.Disturbance of the PI3K/Akt signaling pathway is involved in the progression of polycystic ovary syndrome-insulin resistance (PCOS-IR).In PCOS-IR rats, combined SeNPs and metformin therapy considerably alleviated IR by acting on the PI3K/Akt signaling pathway.The combination of SeNPs and metformi...
Source: Redox Report : communications in free radical research - January 20, 2023 Category: Biochemistry Authors: Hanem M Rabah Darin A Mohamed Reham A Mariah Sarah R Abd El-Khalik Haidy A Khattab Norhan A AbuoHashish Amal M Abdelsattar Mohamed A Raslan Eman E Farghal Amira K Eltokhy Source Type: research

Tolerance strategies employing antigen-coupled apoptotic cells and carboxylated PLG nanoparticles for the treatment of type 1 diabetes.
Authors: Prasad S, Xu D, Miller SD Abstract The development of therapies that specifically target autoreactive immune cells for the prevention and treatment of type 1 diabetes (T1D) without inducing generalized immunosuppression that often compromises the host's ability to clear non-self antigen is highly desired. This review discusses the mechanisms and potential therapeutic applications of antigen-specific T cell tolerance techniques using syngeneic apoptotic cellular carriers and synthetic nanoparticles that are covalently cross-linked to diabetogenic peptides or proteins through ethylene carbodiimide (ECDI) to ...
Source: Review of Diabetic Studies - November 19, 2014 Category: Endocrinology Tags: Rev Diabet Stud Source Type: research

Stearoyl gemcitabine nanoparticles overcome obesity-induced cancer cell resistance to gemcitabine in a mouse postmenopausal breast cancer model.
Abstract Obesity is associated with increased breast tumor aggressiveness and decreased response to multiple modalities of therapy in postmenopausal women. Delivering cancer chemotherapeutic drugs using nanoparticles has evolved as a promising approach to improve the efficacy of anticancer agents. However, the application of nanoparticles in cancer chemotherapy in the context of obesity has not been studied before. The nucleoside analog gemcitabine is widely used in solid tumor therapy. Previously, we developed a novel stearoyl gemcitabine solid-lipid nanoparticle formulation (GemC18-NPs) and showed that the GemC1...
Source: Cancer Biology and Therapy - January 28, 2013 Category: Cancer & Oncology Authors: De Angel RE, Blando JM, Hogan MG, Sandoval MA, Lansakara-P DS, Dunlap SM, Hursting SD, Cui Z Tags: Cancer Biol Ther Source Type: research

Molecules, Vol. 24, Pages 3271: Optimization of Preparation and Preclinical Pharmacokinetics of Celastrol-Encapsulated Silk Fibroin Nanoparticles in the Rat
In conclusion, the preparation of CL-SFNP was optimized and the formulation demonstrated improved pharmacokinetic properties compared to CL in solution following IV administration.
Source: Molecules - September 7, 2019 Category: Chemistry Authors: Onyeabor Paik Kovvasu Ding Lin Wahid Prabhu Betageri Wang Tags: Article Source Type: research

An overview on recent in vivo biological application of cerium oxide nanoparticles
This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer's disease, obesity, liver inflammation, cancer, sepsis, amyotrophic lateral sclerosis, acute kidney injury, radiation-induced tissue damage, hepatic ischemia reperfusion injury, retinal diseases and constipation. In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma, ovarian, breast and retinoblastoma cancer cell-induced mice, with their conjugation with folic acid, doxorubicin, CPM, or CXC receptor-4 antagonist ligand eliciting higher efficiency. After conjugation with tr...
Source: Asian Journal of Pharmaceutical Sciences - November 27, 2019 Category: Drugs & Pharmacology Source Type: research

β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway.
In conclusion, β-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway. PMID: 32945205 [PubMed - in process]
Source: Drug Delivery - September 20, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Quality of information of websites dedicated to obesity: a systematic search to promote high level of information for Internet users and professionals
CONCLUSIONS: These results can inform guidelines for the improvement of health information and help Internet users to achieve a higher level of information. Users must find benefits of treatment, support to the shared decision-making, the sources used, the medical editor's supervision, and the risk of postponing the treatment.PMID:33665782 | DOI:10.1007/s40519-020-01089-x
Source: Eating and weight disorders : EWD - March 5, 2021 Category: Eating Disorders & Weight Management Authors: Alessandra Perra Antonio Preti Valerio De Lorenzo Antonio Egidio Nardi Mauro G Carta Source Type: research