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Condition: Stroke

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Total 55293 results found since Jan 2013.

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke
as Endres, Ulrich Dirnagl & Tracy D Farr
Source: Journal of Cerebral Blood Flow - February 27, 2013 Category: Neurology Authors: Christoph HarmsAnna Lena DatwylerFrank WiekhorstLutz TrahmsRandall LindquistEyk SchellenbergerSusanne MuellerGunnar SchützFarnoosh RoohiAndreas IdeMartina FüchtemeierKaren GertzGolo KronenbergUlrike HarmsMatthias EndresUlrich DirnaglTracy D Farr Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research

Systemically administered brain-targeted nanoparticles transport peptides across the blood–brain barrier and provide neuroprotection
Systemically administered brain-targeted nanoparticles transport peptides across the blood–brain barrier and provide neuroprotection Journal of Cerebral Blood Flow & Metabolism advance online publication, December 10 2014. doi:10.1038/jcbfm.2014.220 Authors: Muge Yemisci, Secil Caban, Yasemin Gursoy-Ozdemir, Sevda Lule, Ramon Novoa-Carballal, Ricardo Riguera, Eduardo Fernandez-Megia, Karine Andrieux, Partick Couvreur, Yilmaz Capan & Turgay Dalkara
Source: Journal of Cerebral Blood Flow - December 10, 2014 Category: Neurology Authors: Muge YemisciSecil CabanYasemin Gursoy-OzdemirSevda LuleRamon Novoa-CarballalRicardo RigueraEduardo Fernandez-MegiaKarine AndrieuxPartick CouvreurYilmaz CapanTurgay Dalkara Tags: cerebrovascular disease/stroke caspases growth factors/cytokines nanoparticles neuroprotection Source Type: research

Nanoparticles to Target Atherosclerotic Plaques
This popular science article takes a look at efforts to develop nanoparticles capable of reducing the size of plaques in blood vessels produced by the processes of atherosclerosis. These plaques narrow and deform blood vessels, ultimately breaking apart to cause blockages and ruptures of blood vessels that are often fatal. Atherosclerosis is caused at root by damaged lipids that enter the circulation and lodge in blood vessel tissue. This is followed by an unfortunate set of self-reinforcing signals sent by cells in the blood vessel wall and then by immune cells that turn up to try to deal with the problem. When immune cel...
Source: Fight Aging! - May 31, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Toxicity and health impact of nanoparticles. Basic biology and clinical perspective.
Authors: Olaru DG, Olaru A, Kassem GH, Popescu-Drigă MV, Pinoşanu LR, Dumitraşcu DI, Popescu EL, Hermann DM, Popa-Wagner A Abstract Stroke has limited restorative treatment options. In search of new therapeutic strategies for the ischemic brain, cell-based therapies offered new hope, which has been, in the meanwhile, converted into a more realistic approach recognizing difficulties related to unfavorable environments causing low survival rates of transplanted neuronal precursors. Stem cell therapies are based on the transplantation of neuronal precursor cells (NPCs), adult stem cells propagated in cell culture o...
Source: Romanian Journal of Morphology and Embryology - January 10, 2020 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis
Conclusion: This study highlights the therapeutic role of stem cells in stroke and also emphasizes nanotechnology as an important tool for monitoring stem cell migration to the affected neurological locus.
Source: Stem Cell Research and Therapy - March 13, 2015 Category: Stem Cells Authors: Leopoldo NucciHelio SilvaViviana GiampaoliJavier MamaniMariana NucciLionel Gamarra Source Type: research

Enhancing the biopharmaceutical attributes of atorvastatin calcium using polymeric and lipid-polymer hybrid nanoparticles: An approach for atherosclerosis treatment
Biomed Pharmacother. 2023 Jan 21;159:114261. doi: 10.1016/j.biopha.2023.114261. Online ahead of print.ABSTRACTAtherosclerosis is associated with inflammation in the arteries, a significant cause of heart attacks and strokes. Although statin therapy can reduce the chances of atherosclerotic plaque formation, they need to be administered in high doses due to low systemic bioavailability and encountered with side effects. To overcome these challenges, we developed nanoparticles using biocompatible and biodegradable lipids and polymers for improving systemic drug absorption and therapeutic response. The polymeric nanoparticles...
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Miao Liu Tingchao Gao Lei Jiang Shunqi Li Bolun Shi Fangxu Li Source Type: research

Design of Disintegrable Nanoassemblies to Release Multiple Small-Sized Nanoparticles
Adv Drug Deliv Rev. 2023 Apr 27:114854. doi: 10.1016/j.addr.2023.114854. Online ahead of print.ABSTRACTThe therapeutic and diagnostic effects of nanoparticles depend on the efficiency of their delivery to targeted tissues, such as tumors. The size of nanoparticles, among other characteristics, plays a crucial role in determining their tissue penetration and retention. Small nanoparticles may penetrate deeper into tumor parenchyma but are poorly retained, whereas large ones are distributed around tumor blood vessels. Thus, compared to smaller individual nanoparticles, assemblies of such nanoparticles due to their larger siz...
Source: Advanced Drug Delivery Reviews - April 29, 2023 Category: Drugs & Pharmacology Authors: Dingcheng Zhu Huijie Yan Yaofeng Zhou Leroy M Nack Junqiu Liu Wolfgang J Parak Source Type: research

Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
Biomaterials. 2021 Aug 31;277:121111. doi: 10.1016/j.biomaterials.2021.121111. Online ahead of print.ABSTRACTIschemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic st...
Source: Biomaterials - September 6, 2021 Category: Materials Science Authors: Wenxiu He Zhiwen Zhang Xianyi Sha Source Type: research

A Comparative Study of Ultrasmall Calcium Carbonate Nanoparticles for Targeting and Imaging Atherosclerotic Plaque
ACS Nano. 2023 Jul 3. doi: 10.1021/acsnano.3c03523. Online ahead of print.ABSTRACTAtherosclerosis is a complex disease that can lead to life-threatening events, such as myocardial infarction and ischemic stroke. Despite the severity of this disease, diagnosing plaque vulnerability remains challenging due to the lack of effective diagnostic tools. Conventional diagnostic protocols lack specificity and fail to predict the type of atherosclerotic lesion and the risk of plaque rupture. To address this issue, technologies are emerging, such as noninvasive medical imaging of atherosclerotic plaque with customized nanotechnologic...
Source: Atherosclerosis - July 3, 2023 Category: Cardiology Authors: Lydia Mart ínez-Parra Marina Pi ñol-Cancer Carlos Sanchez-Cano Ana B Miguel-Coello Desir è Di Silvio Ana M Gomez Clara Uriel Sandra Plaza-Garc ía Marta Gallego Raquel Pazos Hugo Groult Marc Jeannin Kalotina Geraki Laura Fern ández-Méndez Ainhize Urk Source Type: research

Enhancement of combustion effect leading to improved performance and exhaust emissions of an SI engine with ferrous oxide and graphite nanoparticles
Environ Sci Pollut Res Int. 2023 Aug 8. doi: 10.1007/s11356-023-28556-z. Online ahead of print.ABSTRACTThe present study was conducted to investigate the effectiveness of new, less toxic, less harmful, and nonmetallic graphite (G) and metallic iron oxide (Fe2O3) nanofuel additives by analyzing experimentally their consequences on exhaust emissions and performance of an air cooled, single cylinder, 4-stroke gasoline engine. Fe2O3 and graphite nanoparticles at 40, 80, and 120 mg/l of gasoline concentrations were mixed with gasoline by means of a magnetic stirrer. Brake power (BP), brake-specific fuel consumption (BSFC), torq...
Source: Environmental Science and Pollution Research International - August 8, 2023 Category: Environmental Health Authors: Yasir Hussain Siddiqui Muhammad Shakaib Adnan Rasheed Hafiz Muhammad Ali Syed Mohammad Rizwan Azeem Athar Husain Siddique Muhammad Shafiq Source Type: research