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Nanoparticles-mediated emerging approaches for effective treatment of ischemic stroke
Biomaterials. 2021 Aug 31;277:121111. doi: 10.1016/j.biomaterials.2021.121111. Online ahead of print.ABSTRACTIschemic stroke leads to high disability and mortality. The limited delivery efficiency of most therapeutic substances is a major challenge for effective treatment of ischemic stroke. Inspired by the prominent merit of nanoscale particles in brain targeting and blood-brain barrier (BBB) penetration, various functional nanoparticles have been designed as promising drug delivery platforms that are expected to improve the therapeutic effect of ischemic stroke. Based on the complex pathological mechanisms of ischemic st...
Source: Biomaterials - September 6, 2021 Category: Materials Science Authors: Wenxiu He Zhiwen Zhang Xianyi Sha Source Type: research

Peas in a Pod? The Similarities between UFPs and Nanoparticles Yield Research Opportunities
PDF Version (514 KB) About This Article Published: 20 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Nanomaterials Versus Ambient Ultrafine Particles: An Oppor...
Source: EHP Research - October 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Anti-oxidative effect of mangiferin-chitosan nanoparticles on oxidative stress-induced renal cells.
Abstract Oxidative stress is considered to be the leading cause of many chronic and degenerative diseases leading to death and disability. Antioxidant therapy could be efficient in preventing oxidative stress-induced damages in cells. In the present study the efficacy of mangiferin-chitosan nanoparticles (MCNs) as a therapeutic agent against the oxidative stress, since mangiferin (MGF), a polyphenol protects and attenuates oxidative stress against various diseases. However, the bioactivity of MGF does not result in vivo biological effect owing to its low bioavailability and poor solubility. Mangiferin nanoparticle...
Source: International Journal of Biological Macromolecules - February 14, 2020 Category: Biochemistry Authors: Samadarsi R, Dutta D Tags: Int J Biol Macromol Source Type: research

Zinc oxide nanoparticles and L-carnitine effects on neuro-schistosomiasis mansoni induced in mice.
Abstract Neuro-schistosomiasis can induce neurological symptoms and severe disability. Since the resistance against the chemotherapy "praziquantel" was reported, the aim of the present study was investigating the anti-neuro-schistosomal effects of ZnO nanoparticles and/or L-carnitine (as free radicals scavenger) on schistosome-infected mice, where technology of nanoparticles has come to the forefront in the medical diagnosis and therapeutic drug delivery. In the human body, nanoscale-sized particles can move freely and reveal unique biological, mechanical, electrical, and chemical properties. In the present study,...
Source: Environmental Science and Pollution Research International - March 22, 2020 Category: Environmental Health Authors: Bauomy AA Tags: Environ Sci Pollut Res Int Source Type: research

Activation of caspase-dependent apoptosis by intracellular delivery of cytochrome c-based nanoparticles
Conclusions: Our results demonstrate that the coating with a hydrophobic polymer stabilizes Cytochrome c nanoparticles allowing for their delivery to the cytoplasm of target cells. After smart release of Cytochrome c into the cytoplasm, it induced programmed cell death.
Source: Journal of Nanobiotechnology - September 2, 2014 Category: Nanotechnology Authors: Moraima Morales-CruzCindy FigueroaTania González-RoblesYamixa DelgadoAnna MolinaJessica MéndezMyraida MoralesKai Griebenow Source Type: research

Tailoring Lipid and Polymeric Nanoparticles as siRNA Carriers towards the Blood-Brain Barrier – from Targeting to Safe Administration
Abstract Blood-brain barrier is a tightly packed layer of endothelial cells surrounding the brain that acts as the main obstacle for drugs enter the central nervous system (CNS), due to its unique features, as tight junctions and drug efflux systems. Therefore, since the incidence of CNS disorders is increasing worldwide, medical therapeutics need to be improved. Consequently, aiming to surpass blood-brain barrier and overcome CNS disabilities, silencing P-glycoprotein as a drug efflux transporter at brain endothelial cells through siRNA is considered a promising approach. For siRNA enzymatic protection and effici...
Source: Journal of NeuroImmune Pharmacology - May 20, 2016 Category: Drugs & Pharmacology Source Type: research

Evolution of a Search: The Use of Dynamic Twitter Searches During Superstorm Sandy
Conclusion The most important lesson learned from Superstorm Sandy was the need for a dynamic and flexible monitoring process and strategy to understand and respond quickly to health needs in the areas impacted by Superstorm Sandy. Search strategies should change as frequently as the unfolding event. The inability to adapt to a changing situation ensures stale and stagnant terminology and search results. Twitter lists and Boolean searches should be used together to maximize situational awareness. The most important information comes from the impacted population, whether news, local government or local citizens. These are t...
Source: PLOS Currents Disasters - September 26, 2014 Category: Global & Universal Authors: Sara Harris Smith Source Type: research

Targeted drug delivery to ischemic stroke via chlorotoxin-anchored, lexiscan-loaded nanoparticles
Publication date: October 2016 Source:Nanomedicine: Nanotechnology, Biology and Medicine, Volume 12, Issue 7 Author(s): Liang Han, Qiang Cai, Daofeng Tian, Derek K. Kong, Xingchun Gou, Zeming Chen, Stephen M. Strittmatter, Zuoheng Wang, Kevin N. Sheth, Jiangbing Zhou Ischemic stroke is a leading cause of disability and death worldwide. Current drug treatment for stroke remains inadequate due to the existence of the blood–brain barrier. We proposed an innovative nanotechnology-based autocatalytic targeting approach, in which the blood–brain barrier modulator lexiscan is encapsulated in nanoparticles to enhan...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - June 10, 2016 Category: Nanotechnology Source Type: research

Development and evaluation ofDesvenlafaxine loaded PLGA-Chitosan nanoparticles for brain delivery
Publication date: Available online 23 December 2016 Source:Saudi Pharmaceutical Journal Author(s): Gui-Feng Tong, Nan Qin, Li-Wei Sun Depression is a debilitating psychiatric condition that remains the second most common cause of disability worldwide. Currently, depression affects more than 4 percent of the world’s population. Most of the drugs intended for clinical management of depression augment the availability of neurotransmitters at the synapse by inhibiting their neuronal reuptake. However, the therapeutic efficacy of antidepressants is often compromised as they are unable to reach brain by the conventional route...
Source: Saudi Pharmaceutical Journal - December 23, 2016 Category: Drugs & Pharmacology Source Type: research

Chitosan nanoparticles release nimodipine in response to tissue acidosis to attenuate spreading depolarization evoked during forebrain ischemia.
Abstract Stroke is an important cause of mortality and disability. Treatment options are limited, therefore the progress in this regard is urgently needed. Nimodipine, an L-type voltage-gated calcium channel antagonist dilates cerebral arterioles, but its systemic administration may cause potential side effects. We have previously constructed chitosan nanoparticles as drug carriers, which release nimodipine in response to decreasing pH typical of cerebral ischemia. Here we have set out to evaluate this nanomedical approach to deliver nimodipine selectively to acidic ischemic brain tissue. After washing a nanoparti...
Source: Neuropharmacology - November 8, 2019 Category: Drugs & Pharmacology Authors: Tóth OM, Menyhárt Á, Varga VÉ, Hantosi D, Ivánkovits-Kiss O, Varga DP, Szabó Í, Janovák L, Dékány I, Farkas E, Bari F Tags: Neuropharmacology Source Type: research

Erythrocyte Membrane-Enveloped Salvianolic Acid B Nanoparticles Attenuate Cerebral Ischemia-Reperfusion Injury
CONCLUSION: The designed brain targeted biomimetic nanomedicine RR@SABNPs can significantly prolong the half-time of SAB, deliver SAB into the ischemic brain and exhibit good therapeutic effects on MCAO/R model mice.PMID:35974873 | PMC:PMC9376004 | DOI:10.2147/IJN.S375908
Source: Cell Research - August 17, 2022 Category: Cytology Authors: Shanshan Zhang Ruoqi Li Yingyi Zheng Yuan Zhou Xiang Fan Source Type: research

Effectiveness of job search interventions: A meta-analytic review.
The current meta-analytic review examined the effectiveness of job search interventions in facilitating job search success (i.e., obtaining employment). Major theoretical perspectives on job search interventions, including behavioral learning theory, theory of planned behavior, social cognitive theory, and coping theory, were reviewed and integrated to derive a taxonomy of critical job search intervention components. Summarizing the data from 47 experimentally or quasi-experimentally evaluated job search interventions, we found that the odds of obtaining employment were 2.67 times higher for job seekers participating in jo...
Source: Psychological Bulletin - March 3, 2014 Category: Psychiatry & Psychology Authors: Liu, Songqi; Huang, Jason L.; Wang, Mo Source Type: research

Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury.
This study examines the ability of PLGA nanoparticles coated with poloxamer 188 (PX) to deliver BDNF into the brain and neuroprotective effects of BNDF in mice with TBI. C57bl/6 mice were subjected to weight-drop closed head injuries under anesthesia. Using enzyme-linked immunosorbent assay, we demonstrated that the intravenous (IV) injection of nanoparticle-bound BDNF coated by PX (NP-BDNF-PX) significantly increased BDNF levels in the brain of sham-operated mice (p < 0.001) and in both ipsi- (p < 0.001) and contralateral (p < 0.001) parts of brain in TBI mice compared to controls. The present study a...
Source: Drug Delivery - June 11, 2016 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Nanoparticles formulation and in vitro efficacy testing of the mitoNEET ligand NL-1 for drug delivery in a brain endothelial model of ischemic reperfusion-injury
This study lays the preliminary work for potential use of mitoNEET as a target and NL-1 as a therapeutic for the treatment of cerebral ischemia and reperfusion injury.Graphical abstract
Source: International Journal of Pharmaceutics - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Functions and applications of metallic and metallic oxide nanoparticles in orthopedic implants and scaffolds
AbstractBone defects and diseases are devastating, and can lead to severe functional deficits or even permanent disability. Nevertheless, orthopedic implants and scaffolds can facilitate the growth of incipient bone and help us to treat bone defects and diseases. Currently, a wide range of biomaterials with distinct biocompatibility, biodegradability, porosity, and mechanical strength is used in bone ‐related research. However, most orthopedic implants and scaffolds have certain limitations and diverse complications, such as limited corrosion resistance, low cell proliferation, and bacterial adhesion. With recent advance...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - August 8, 2020 Category: Materials Science Authors: Niyou Wang, Jerry Ying Hsi Fuh, S Thameem Dheen, A Senthil Kumar Tags: REVIEW ARTICLE Source Type: research