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Chemo-Carrying Gold Nanoparticles Tested on Mesothelioma
Italian researchers have found early success using gold nanoparticles as a chemotherapy-delivery vehicle for mesothelioma. They are hopeful their discovery will lead to an improvement in mesothelioma treatment in the future. The researchers tested their strategy on pleural mesothelioma cells in the lab. They first designed gold nanoparticles with a specific antibody targeted to the cells. Then they loaded the chemotherapy drug Alimta (pemetrexed) into the nanoparticles and observed its effect on the cancer cells. Delivering Alimta through the gold nanoparticles proved more effective than standard chemotherapy. But the me...
Source: Asbestos and Mesothelioma News - February 12, 2019 Category: Environmental Health Authors: Matt Mauney Source Type: news

Inhibition of Murine Breast Cancer Metastases by Hydrophilic As4S4 Nanoparticles Is Associated With Decreased ROS and HIF-1 α Downregulation
Conclusion It was showed that e-As4S4 could alleviate the metastatic features of aggressive breast cancers through correcting the tumor microenvironment, which prolonged the survival of tumor-bearing mice, showing its important therapeutic implications to the anti-metastasis therapy for breast cancer. Ethics Statement Six-week-old, female BALB/c mice were bred at the Experimental Animal Center at the Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (Beijing, China) under specific pathogen-free conditions. All the animal experiments reported herein were carried out in compliance with the regulatio...
Source: Frontiers in Oncology - April 26, 2019 Category: Cancer & Oncology Source Type: research

Human biomonitoring and personal air monitoring. An integrated approach to assess exposure of stainless-steel welders to metal-oxide nanoparticles
Environ Res. 2022 Nov 4:114736. doi: 10.1016/j.envres.2022.114736. Online ahead of print.ABSTRACTIn welding, there is a potential risk due to metal-oxide nanoparticles (MONPs) exposure of workers. To investigate this possibility, the diameter and number particles concentration of MONPs were evaluated in different biological matrices and in personal air samples collected from 18 stainless-steel welders and 15 unexposed administrative employees engaged in two Italian mechanical engineering Companies. Exhaled breath condensate (EBC) and urine were sampled at pre-shift on 1st day and post-shift on 5th day of the workweek, whil...
Source: Environmental Research - November 7, 2022 Category: Environmental Health Authors: Beatrice Bocca Veruscka Leso Beatrice Battistini Stefano Caimi Marta Senofonte Mauro Fedele Domenico Maria Cavallo Andrea Cattaneo Piero Lovreglio Ivo Iavicoli Source Type: research

Effects of surface sterilisation with green synthesised silver nanoparticles on Lamiaceae seeds
In this study, an alternative surface sterilisation method was established for plant tissue cultures. Silver nanoparticles synthesised via green synthesis were used for the surface sterilisation of Lamiaceae seeds (Salvia farinecae, Ocimum basilicum - Large Leaf Italian, Thymus vulgaris, Ocimum basilicum var. purpurascens). Water extracts of dried Alkanna tinctorum rhizomes and Syzygium aromaticum flowers were utilised in the bioreduction of silver ions. The seeds were exposed to 0, 1, 7, 14 and 28 day-old colloidal solutions of silver nanoparticles and their effects on germination and surface sterilisation were determined...
Source: IET Nanobiotechnology - August 14, 2018 Category: Nanotechnology Source Type: research

Gold Nanoparticles Help Uncover Fine Structure of Amyloid Fibrils
A team of scientists, based at Swiss Federal Institute of Technology Lausanne (EPFL) with collaborators at Ulm University in Germany, University of Modena and Reggio Emilia in Italy, and MIT, have developed custom nanoparticles for high-resolution de...
Source: Medgadget - March 30, 2020 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Nanomedicine Neurology Neurosurgery Radiology Source Type: blogs

Moderators of Career Calling and Job ‐Search Behaviors Among Unemployed Individuals
This study suggests that perceiving a calling is an important personal resource that is related to a clearer job‐search goal and to more intense job‐search activities and can support job seekers in personal adverse conditions. These results suggest integrating job‐search behavio rs in the work‐as‐calling theory and that incorporating the construct of calling into career counselors' practices may increase the efficacy of job‐search activities.
Source: The Career Development Quarterly - December 6, 2020 Category: Psychiatry & Psychology Authors: Anna Dalla Rosa, Michelangelo Vianello, Elisa Maria Galliani, Ryan D. Duffy Tags: Article Source Type: research

Quality of information of websites dedicated to obesity: a systematic search to promote high level of information for Internet users and professionals
CONCLUSIONS: These results can inform guidelines for the improvement of health information and help Internet users to achieve a higher level of information. Users must find benefits of treatment, support to the shared decision-making, the sources used, the medical editor's supervision, and the risk of postponing the treatment.PMID:33665782 | DOI:10.1007/s40519-020-01089-x
Source: Eating and weight disorders : EWD - March 5, 2021 Category: Eating Disorders & Weight Management Authors: Alessandra Perra Antonio Preti Valerio De Lorenzo Antonio Egidio Nardi Mauro G Carta Source Type: research

A GIS-based Quantitative Approach for the Search of Clandestine Graves, Italy.
Abstract Previous research on the RAG color-coded prioritization systems for the discovery of clandestine graves has not considered all the factors influencing the burial site choice within a GIS project. The goal of this technical note was to discuss a GIS-based quantitative approach for the search of clandestine graves. The method is based on cross-referenced RAG maps with cumulative suitability factors to host a burial, leading to the editing of different search scenarios for ground searches showing high-(Red), medium-(Amber), and low-(Green) priority areas. The application of this procedure allowed several out...
Source: Journal of Forensic Sciences - October 30, 2017 Category: Forensic Medicine Authors: Somma R, Cascio M, Silvestro M, Torre E Tags: J Forensic Sci Source Type: research

Loss of smell and taste: a new marker of COVID-19? Tracking reduced sense of smell during the coronavirus pandemic using search trends.
CONCLUSIONS: We feel that Google search trends relating to loss of smell can be utilized to identify potential Covid-19 outbreaks on a national and regional basis. PMID: 32673122 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - July 18, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research

What People Search for When Browsing "Doctor Google." An Analysis of Search Trends in Italy after the Law on Pain.
Authors: Miceli L, Bednarova R, Bednarova I, Rizzardo A, Cobianchi L, Dal Mas F, Biancuzzi H, Bove T, Dal Moro F, Zattoni F Abstract Italy adopted a law on chronic pain in March 2010, which focused on detection and management of this symptom, that affects approximately 25% of the population. The aim of this study is to analyze the interest of the Italian population in palliative care and chronic pain and to understand whether the Law 38/2010 made an impact on the internet search on chronic pain. Five research parameters were included using Google Trends (chronic pain, anti-inflammatory drugs, opioids, fibromyalgia,...
Source: Journal of Pain and Palliative Care Pharmacotherapy - February 13, 2021 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research

Quit smoking search interest in Google Trends from Turkey, UK, France, Italy, and Germany: What happened during the COVID-19 pandemic?
We aimed to evaluate whether Google search interest for smoking cessation has changed from 2018-2019 to 2020, during the pandemic days.Google trends search interest was examined for 2018, 2019, and 2020. Relative Search Volume Interest (RSV) for the term "quit smoking" was obtained from Google Trends. Statistics were given as median (IQR), and statistical analyses performed using the Mann-Whitney U test. We have found that average median (IQR) RSV values for Turkey were 34.50(28.12-40.00), for the UK were 58.50(51.62-65.00), for France were 43.00(35.00-52.00), for Italy were 56.50(50.12-65.00), and for Germany were 33.00(2...
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Uysal, M., Niksarlıoglu, E. Y., Cifter, A., Carkoglu, A. Tags: Tobacco, smoking control and health education Source Type: research

A cross-cultural comparison of visual search strategies and response times in road hazard perception testing.
Abstract Road hazard perception is considered the most prominent higher-order cognitive skill related to traffic-accident involvement. Regional cultures and social rules that govern acceptable behavior may influence drivers' interpretation of a traffic situation and, consequently, the correct identification of potentially hazardous situations. Here, we aimed to compare hazard perception skills among four European countries that differ in their traffic culture, policies to reduce traffic risks, and fatal crashes: Ukraine, Italy, Spain, and Sweden. We developed a static hazard perception test in which driving scenes...
Source: Accident; Analysis and Prevention. - November 5, 2020 Category: Accident Prevention Authors: Di Stasi LL, Diaz-Piedra C, Morales JM, Kurapov A, Tagliabue M, Bjärtå A, Megias A, Bernhardsson J, Paschenko S, Romero S, Cándido A, Catena A Tags: Accid Anal Prev Source Type: research