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Drug: Nicotine
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Total 8595 results found since Jan 2013.
Lipid-drug-conjugate (LDC) solid lipid nanoparticles (SLN) for the delivery of nicotine to the oral cavity - optimization of nicotine loading efficiency.
In this study, lipid-drug-conjugates (LDC) were formed by nicotine and different fatty acids to enable the production of sufficiently loaded nicotine lipid nanoparticles. The encapsulation efficiency of nicotine in LDC-containing SLN was about 50%, which increased at least fourfold compared to the non-LDC formulations (around 10%) due to the increased lipophilicity of nicotine by strong interactions between positively charged nicotine and negatively charged fatty acids (formation of LDCs). The z-average of all formulations (150 to 350 nm) proved to be in the required submicron size range with a narrow size distribution. In...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 12, 2018 Category: Drugs & Pharmacology Authors: Ding Y, Nielsen KA, Nielsen BP, Bøje NW, Müller RH, Pyo SM Tags: Eur J Pharm Biopharm Source Type: research
Nicotine hydrogen tartrate loaded chitosan nanoparticles: Formulation, characterization and in vitro delivery from dry powder inhaler formulation.
This study reports the development of nanoparticles in the form of inhalable micro-aggregates of biodegradable chitosan (CS) loaded with nicotine hydrogen tartrate (NHT) for potential pulmonary delivery of nicotine from dry powder inhaler (DPI) formulations with prolonged release profile. The NHT-loaded CS particles were prepared using a water-in-oil emulsion crosslinking method. The prepared particles were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) for morphological studies; Zetasizer and Mastersizer were applied for particle size analysis. The in vitro aerosolization...
Source: European Journal of Pharmaceutics and Biopharmaceutics - January 10, 2017 Category: Drugs & Pharmacology Authors: Wang H, George G, Bartlett S, Gao C, Islam N Tags: Eur J Pharm Biopharm Source Type: research
Molecules, Vol. 24, Pages 4620: Nucleic Acid Nanoparticles at a Crossroads of Vaccines and Immunotherapies
a
Vaccines and immunotherapies involve a variety of technologies and act through different mechanisms to achieve a common goal, which is to optimize the immune response against an antigen. The antigen could be a molecule expressed on a pathogen (e.g., a disease-causing bacterium, a virus or another microorganism), abnormal or damaged host cells (e.g., cancer cells), environmental agent (e.g., nicotine from a tobacco smoke), or an allergen (e.g., pollen or food protein). Immunogenic vaccines and therapies optimize the immune response to improve the eradication of the pathogen or damaged cells. In contrast, tolerogenic v...
Source: Molecules - December 16, 2019 Category: Chemistry Authors: Marina A. Dobrovolskaia Tags: Review Source Type: research
Examining the Relationship Between Past Orientation and US Suicide Rates: An Analysis Using Big Data-Driven Google Search Queries
Conclusions: We empirically identified the positive relationship between the suicide rate and past orientation, which was measured by big data-driven Google search query.
Source: Journal of Medical Internet Research - February 11, 2016 Category: Journals (General) Authors: Donghyun LeeHojun LeeMunkee Choi Source Type: research
Selenium nanoparticles with low-level ionizing radiation exposure ameliorate nicotine-induced inflammatory impairment in rat kidney.
Abstract
Occupational exposure to low-level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. Nicotine, a major toxic component of cigarette smoke, is responsible for smoking-mediated renal dysfunction. The present study was therefore aimed to investigate the protective impact of ginger Zingiber officinale selenium nanoparticles (SeNPs) with whole-body low-dose gamma radiation (γ-R) against nicotine-induced nephrotoxicity in male albino rats. Nicotine intoxication was induced with 0.5 mg/kg BW. Rats received 0.1 mg SeNPs/kg BW by gastric gav...
Source: Environmental Science and Pollution Research International - July 9, 2017 Category: Environmental Health Authors: Zahran WE, Elsonbaty SM, Moawed FSM Tags: Environ Sci Pollut Res Int Source Type: research
Influence of legislations and news on Indian internet search query patterns of e-cigarettes
Conclusions: These findings suggest that search for information on ENDS is increasing and that these tobacco control policies and news items, targeting tobacco usage reduction, have only a short-term effect on the rate of searching for information on ENDS.
Source: Journal of Oral and Maxillofacial Pathology - August 18, 2017 Category: ENT & OMF Authors: Rooban Thavarajah Anusa Arunachalam Mohandoss Kannan Ranganathan Srinivas Kondalsamy-Chennakesavan Source Type: research
Nicotinamide adenine dinucleotide immobilized tungsten trioxide nanoparticles for simultaneous sensing of norepinephrine, melatonin and nicotine.
Abstract
Herein, we report the anionic surfactant, ethylene diamine tetraacetic acid (EDTA), mediated synthesis of WO3 nanoparticles and its subsequent modification through gamma irradiation (GI) and electrochemical immobilization with nicotinamide adenine dinucleotide (NAD). Glassy carbon electrode (GCE) modified with GI-WO3 NPs and the enzyme NAD exhibited strong electro-oxidation of three important biomolecules such as norepinephrine (NEP), melatonin (MEL) and nicotine (NIC) in 0.1 M phosphate buffer saline (PBS) at physiological pH of 7. Square wave voltammetry (SWV) studies exhibited three well-defined peak...
Source: Biosensors and Bioelectronics - August 15, 2019 Category: Biotechnology Authors: Anithaa AC, Asokan K, Lavanya N, Sekar C Tags: Biosens Bioelectron Source Type: research
Assessment of nicotine release from nicotine-loaded chitosan nanoparticles dry powder inhaler formulations via locomotor activity of C57BL/6 mice.
CONCLUSIONS: The results indicated the inhaled NHT-CS is a viable preclinical option for developing novel inhalation formulations as a potential anti-smoking therapeutic.
PMID: 32682941 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutics and Biopharmaceutics - July 15, 2020 Category: Drugs & Pharmacology Authors: Wang H, Holgate J, Bartlett S, Islam N Tags: Eur J Pharm Biopharm Source Type: research
Why do adult dogs (Canis familiaris) commit the A-not-B search error?
It has been recently reported that adult domestic dogs, like human infants, tend to commit perseverative search errors; that is, they select the previously rewarded empty location in Piagetian A-not-B search task because of the experimenter’s ostensive communicative cues. There is, however, an ongoing debate over whether these findings reveal that dogs can use the human ostensive referential communication as a source of information or the phenomenon can be accounted for by “more simple” explanations like insufficient attention and learning based on local enhancement. In 2 experiments the authors systematically manipu...
Source: Journal of Comparative Psychology - August 19, 2013 Category: Psychiatry & Psychology Authors: Sümegi, Zsófia; Kis, Anna; Miklósi, Ádám; Topál, József Source Type: research
Identifying e-cigarette vape stores: description of an online search methodology
Conclusions
Using the online search methodology we identified more ENDS vape stores than were on the state tobacco licensure list. This approach may be a promising strategy to identify and track the growth of ENDS vape stores over time, especially in states without a systematic licensing requirement for such stores.
Source: Tobacco Control - March 30, 2016 Category: Respiratory Medicine Authors: Kim, A. E., Loomis, B., Rhodes, B., Eggers, M. E., Liedtke, C., Porter, L. Tags: Articles Source Type: research
Can CuO nanoparticles lead to epigenetic regulation of antioxidant enzyme system?
Abstract
Copper has been used from ancient time in various applications. Scientists have exploited its means of exposure and consequences to living organisms. The peculiar property of nanomaterials that is a high surface to volume ratio has increased the range of application in products. Copper oxide nanoparticles (CuO NPs) are widely used in industrial applications such as semiconductor devices, gas sensor, batteries, solar energy converter, microelectronics, heat transfer fluids and consumer products. In contrast, acute toxicity of CuO NPs has also been reported. Subsequently, human and environmental health may be at a h...
Source: Journal of Applied Toxicology - September 30, 2016 Category: Toxicology Authors: Sandesh Chibber, Rishi Shanker Tags: Hyphothesis review Source Type: research
Tethered nanoparticles make tumor cells more vulnerable
(Massachusetts Institute of Technology) MIT researchers have devised a way to make cancer cells more susceptible to certain types of cancer treatment, by coating the cells with nanoparticles before delivering drugs. By tethering hundreds of tiny particles to the surfaces of tumor cells, the researchers made the cells much more vulnerable to attack by a drug called TRAIL that triggers cancer cells to commit suicide.
Source: EurekAlert! - Medicine and Health - March 20, 2017 Category: Global & Universal Source Type: news
Erratum to: Selenium nanoparticles with low-level ionizing radiation exposure ameliorate nicotine-induced inflammatory impairment in rat kidney.
PMID: 28819934 [PubMed - as supplied by publisher]
Source: Environmental Science and Pollution Research International - August 17, 2017 Category: Environmental Health Authors: Zahran WE, Elsonbaty SM, Moawed FSM Tags: Environ Sci Pollut Res Int Source Type: research
The possible protective role of zinc oxide nanoparticles (ZnONPs) on testicular and epididymal structure and sperm parameters in nicotine-treated adult rats (a histological and biochemical study)
AbstractExposure to nicotine in smoking contributes to most unexplained male infertility but the mechanisms remain to be fully elucidated. Zinc (Zn) is an essential trace element in normal growth, development and reproduction. Zinc oxide nanoparticles(ZnONPs) are well-known antioxidants. Therefore, this work was designed to investigate the potential ability of ZnONPs to protect testis and epididymis in nicotine-treated rats. Forty adult male Wistar albino rats were divided into control group and two experimental groups (treated and supplemented rats). In the treated group, rats received nicotine at a dose of 1 mg/kg/day ...
Source: Cell and Tissue Research - September 14, 2018 Category: Cytology Source Type: research
Nicotinamide adenine dinucleotide immobilized tungsten trioxide nanoparticles for simultaneous sensing of norepinephrine, melatonin and nicotine
Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): A.C. Anithaa, K. Asokan, N. Lavanya, C. SekarAbstractHerein, we report the anionic surfactant, ethylene diamine tetraacetic acid (EDTA), mediated synthesis of WO3 nanoparticles and its subsequent modification through gamma irradiation (GI) and electrochemical immobilization with nicotinamide adenine dinucleotide (NAD). Glassy carbon electrode (GCE) modified with GI-WO3 NPs and the enzyme NAD exhibited strong electro-oxidation of three important biomolecules such as norepinephrine (NEP), melatonin (MEL) and nicotine (NIC) in 0.1 M...
Source: Biosensors and Bioelectronics - August 21, 2019 Category: Biotechnology Source Type: research
