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Total 17096 results found since Jan 2013.

SAXS characterization of polymer-embedded hollow nanoparticles and of their shell porosityThis article will form part of a virtual special issue of the journal, presenting some highlights of the 15th International Small-Angle Scattering Conference (SAS2012). This special issue will be available in late 2013/early 2014.
Size parameters of SiO2/TiO2 hollow nanoparticles (HNPs) of 25–100 nm in diameter were characterized by small-angle X-ray scattering (SAXS). On the basis of the decoupling and the Percus–Yevick approximations, and using a hollow sphere model, size information on HNPs was extracted, including average outer diameter, average inner diameter and polydispersity. Application of an alternative form factor based on hollow ellipsoids, and of a sticky hard sphere structure factor, did not improve the fit significantly. The shell porosity of the HNPs and the size of the pores in the HNP shell were further characterized by combi...
Source: Journal of Applied Crystallography - November 7, 2013 Category: Physics Authors: Chen, Z.H.Hwang, S.H.Zeng, X.Roh, J.Jang, J.Ungar, G. Tags: hollow nanoparticles small-angle X-ray scattering research papers Source Type: research

Using Robots and Artificial Intelligence to Search for New Medicines
Courtesy of Dr. Adam Gormley. Adam Gormley, Ph.D., describes himself as a creative and adventurous person—albeit, not creative in the traditional sense. “Science allows me to be creative; to me, it’s a form of art. I love being outdoors, going on sailing trips, and spending time adventuring with my family. Research is the same—it’s an adventure. My creative and adventurous sides have combined into a real love for science,” he says. Dr. Gormley currently channels his passion for science into his position as an assistant professor of biomedical engineering at Rutgers University in Piscataway, New Jersey. Lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 24, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Medicines Profiles Source Type: blogs

Next Phase of NIH Preprint Pilot Launching Soon
Last month, the National Library of Medicine (NLM)announced plans to extend its NIH Preprint Pilot in PubMed Central (PMC) and PubMed beyond COVID-19 to encompass all preprints reporting on NIH-funded research. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award, contract, or intramural program and posted to aneligible preprint server on or after January 1, 2023.In preparation for the launch of this second phase, we have updated PMC and PubMed site features to help users of these databases incorporate the increased volume of preprints into their discovery workflows. S...
Source: PubMed Central News - January 10, 2023 Category: Databases & Libraries Source Type: news

Second Phase of the NIH Preprint Pilot Launched
Today, we are pleased to announce the launch of the second phase of the NIH Preprint Pilot with the addition of more than 700 new preprint records to PubMed Central (PMC) and PubMed. This second phase expands the scope of the Pilot to include preprints resulting from all NIH-funded research. Eligible preprints are those acknowledging direct support of an NIH award or authored by NIH staff and posted to bioRxiv, medRxiv, arXiv, or Research Square, on or after January 1, 2023. NLM will automatically include the full text of the preprint (as license terms allow) and associated citation information in PMC and PubMed, respectiv...
Source: PubMed Central News - January 30, 2023 Category: Databases & Libraries Source Type: news

Preparation and characterization of amorphous amphotericin B nanoparticles for oral administration through liquid antisolvent precipitation.
Abstract We prepared amphotericin B (AmB) nanoparticles through liquid antisolvent precipitation (LAP) and by freeze-drying to improve the solubility of AmB for oral administration. The LAP was optimized through a single-factor experiment. We determined the effects of surfactants and their concentration, the stirring time, the precipitation temperature, the stirring intensity, the drug concentration and the volume ratio of antisolvent to solvent on the mean particle size (MPS) of the AmB nanoparticles. Increased stirring intensity and precipitation time favored AmB nanoparticles with smaller MPS, but precipitation...
Source: European Journal of Pharmaceutical Sciences - December 14, 2013 Category: Drugs & Pharmacology Authors: Zu Y, Sun W, Zhao X, Wang W, Li Y, Ge Y, Liu Y, Wang K Tags: Eur J Pharm Sci Source Type: research

Abstract IA18: Targeted polymeric nanoparticles: From academic innovations to clinical trials and lessons learned
A variety of organic and inorganic materials have been utilized to generate nanoparticles for drug delivery applications, including polymeric nanoparticles, dendrimers, nanoshells, liposomes, nucleic acid based nanoparticles, magnetic nanoparticles, and virus nanoparticles. The two most commonly used systems are polymeric nanoparticles and liposomes [1, 2]. Controlled release polymer technology has impacted virtually every branch of medicine, including ophthalmology, pulmonary, pain medicine, endocrinology, cardiology, orthopedics, immunology, neurology and dentistry, with several of these systems in clinical practice toda...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Omid C. Farokhzad Tags: Drug Delivery and Nanomedicine Source Type: research

Abstract B54: SR-B1 directed nanoparticles in targeted therapy for the treatment of metastatic triple-negative breast cancer
This study endeavors to fill a void in the treatment of metastatic triple negative breast cancer (TNBC) with the use of scavenger receptor class B type 1 (SR-B1) targeted reconstituted high-density lipoprotein (rHDL) nanoparticles. Though new therapies are being evaluated in clinical trials, TNBC remains an incurable disease. Accordingly, the 5-year survival rate for women with metastatic TNBC is less than 30%. The overall goal of this study is to evaluate the efficacy of Lapatinib (an EGFR inhibitor) and Valrubicin (a topoisomerase II inhibitor) encapsulated rHDL nanoparticles in the treatment of metastatic TNBC. Selectiv...
Source: Cancer Epidemiology Biomarkers and Prevention - September 30, 2015 Category: Cancer & Oncology Authors: Johnson, R., Lacko, A. Tags: Breast Cancer: Poster Presentations - Proffered Abstracts Source Type: research

Abstract B46: Development of biodegradable Fn14-targeted nanoparticles for controlled drug delivery for invasive brain tumors
Conclusion: We have developed a nanoparticle platform that can diffuse and penetrate within brain tissue and selectively target remote experimental GBM tumors. Using this approach we can optimize therapeutics versions to improve drug efficacy while limiting many of the side effects and risks of free drug and non-targeted therapies.Citation Format: Jimena G. Perez, Craig S. Schneider, Nina Connolly, Jeffrey A. Winkles, Graeme F. Woodworth, Anthony J. Kim. Development of biodegradable Fn14-targeted nanoparticles for controlled drug delivery for invasive brain tumors. [abstract]. In: Proceedings of the AACR Special Conference...
Source: Cancer Research - December 9, 2015 Category: Cancer & Oncology Authors: Perez, J. G., Schneider, C. S., Connolly, N., Winkles, J. A., Woodworth, G. F., Kim, A. J. Tags: Other Topics Source Type: research

Abstract B41: Gold nanoparticles based platforms for localized radiosensitization in cancer radiation therapy
The use of nanoparticles with high atomic (Z) number have been known to attenuate X-rays and the unique properties associated with gold nanoparticles makes them as potent radiosensitizers for enhancing Radiotherapy (RT) treatments. The interaction of high Z materials with the X-rays results in photoelectric absorption which leads to generation of photoelectrons. These low energy photoelectrons can deliver lethal energy in the close proximity. The success of cancer radiation therapy relies heavily on the effective delivery of radiation dose to the tumor site sparing the surrounding normal tissues. To overcome the limitation...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Rajiv Kumar, Wilfred Ngwa, Vinit Joshi, Sijumon Kunjachan, Ross Berbeco, Mike Makrigiorgos, Srinivas Sridhar Tags: Drug Delivery and Nanomedicine Source Type: research

Peas in a Pod? The Similarities between UFPs and Nanoparticles Yield Research Opportunities
PDF Version (514 KB) About This Article Published: 20 October 2017 Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days. Related EHP Article Nanomaterials Versus Ambient Ultrafine Particles: An Oppor...
Source: EHP Research - October 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Science Selection Source Type: research

Abstract B21: Use of polymeric nanoparticles for the delivery of YM155 to glioma cells in vitro and in vivo
YM155 (Sepantronium Bromide) is a potent survivin inhibitor that is the subject of clinical trials for multiple types of cancer including melanoma, lypmphoma, lung cancer, prostate and breast cancer. YM155 is a therapeutic candidate for the treatment of glioblastoma (GBM), however, its rapid plasma clearance and minimal blood-brain barrier penetration are obstacles to clinical translation (1). The encapsulation of drugs in nanoparticles can help increase drug circulation time by reducing clearance, and nanoparticles have the ability to increase drug concentration in the tumor through the enhanced permeability and retention...
Source: Cancer Research - December 9, 2015 Category: Cancer & Oncology Authors: Householder, K. T., DiPerna, D. M., Yamaguchi, J. T., Sanai, N., Mehta, S., Sirianni, R. W. Tags: Preclinical Therapeutics/Trials/Models Source Type: research

Intravitreal mobility of nanoparticles: how to make a move toward successful ocular gene delivery?
SummaryIntravitreal injection is an interesting delivery route for the administration of nanoparticles for treatment of a variety of retinopathies. To reach the retina, nanoparticles need to diffuse through the vitreous and travel across the vitreoretinal interface. We have recently optimized an ex vivo assay that allows to measure the mobility of fluorescent nanoparticles in intact vitreous humour on a single‐particle level. With this model, we optimize surface coating strategies of nanoparticles to assure good vitreal mobility, while maintaining the normal transfection efficiency. Also, we developed a novel ex vivo ret...
Source: Acta Ophthalmologica - September 13, 2016 Category: Opthalmology Authors: K. Remaut, J. Devoldere, K. Peynshaert, T. Martens, J. Engbersen, K. Braeckmans, S. De Smedt Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

Abstract B42: Silencing of DNA repair proteins with ECO/siRNA nanoparticles for the enhancement of radiation response in glioblastoma
In this study we investigate the use of these nanoparticles to deliver siRNA to inhibit ATM and DNApk activity and enhance radiation response in both glioma and glioma stem cell lines.Established glioma (U251) and glioma stem cell (NSC11) lines were used to evaluate the effectiveness of ECO nanoparticle delivery of siRNA in vitro . Cellular uptake of ECO nanoparticles loaded with fluorescent siRNA was assessed using flow cytometry and fluorescent microscopy, demonstrating the rapid uptake of ECO/siRNA nanoparticles in comparison to commercially available transfection agents. Protein and mRNA analyses revealed the kinetics ...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Jennifer A. Lee, Nadia Ayat, Anita Tandle, Zheng-Rong Lu, Kevin Camphausen Tags: Drug Delivery and Nanomedicine Source Type: research

Abstract B45: Silencing ss3 integrin by targeted ECO/siRNA nanoparticles inhibits EMT and metastasis of triple-negative breast cancer
Metastatic breast cancer is the second leading cause of cancer-related deaths among women. Triple-negative breast cancer (TNBC) is a highly aggressive subcategory of breast cancer and currently lacks well-defined molecular targets for effective targeted therapies. Disease relapse, metastasis, and drug resistance render standard chemotherapy ineffective in the treatment of TNBC. Because previous studies coupled β3 integrin (ITGB3) to epithelial-mesenchymal transition (EMT) and metastasis, we exploited β3 integrin as a therapeutic target to treat TNBC by delivering β3 integrin siRNA via lipid ECO-based nanoparticles (ECO/...
Source: Cancer Research - January 15, 2017 Category: Cancer & Oncology Authors: Jenny G. Parvani, Maneesh D. Gujrati, Margaret A. Mack, William P. Schiemann, Zheng-Rong Lu Tags: Drug Delivery and Nanomedicine Source Type: research

Molecules, Vol. 22, Pages 2038: Preparation of Vitexin Nanoparticles by Combining the Antisolvent Precipitation and High Pressure Homogenization Approaches Followed by Lyophilization for Dissolution Rate Enhancement
Yujie Fu Vitexin, a natural flavonoid found in many medicinal plants, is well known for its rich pharmacological activities. However, the poor water solubility of vitexin has limited its therapeutic application. The aim of this study was to prepare the nanoparticles of vitexin by combining the antisolvent precipitation (ASP) and high pressure homogenization (HPH) approaches followed by lyophilization for improving the dissolution rate of this poorly water-soluble drug. The effects of main factors influencing the mean particle size (MPS) of vitexin were investigated and optimized. Under optimum conditions, vitexin na...
Source: Molecules - November 22, 2017 Category: Chemistry Authors: Chengbo Gu Ziwei Liu Xiaohan Yuan Wang Li Yuangang Zu Yujie Fu Tags: Article Source Type: research