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Using Robots and Artificial Intelligence to Search for New Medicines
Courtesy of Dr. Adam Gormley.
Adam Gormley, Ph.D., describes himself as a creative and adventurous person—albeit, not creative in the traditional sense. “Science allows me to be creative; to me, it’s a form of art. I love being outdoors, going on sailing trips, and spending time adventuring with my family. Research is the same—it’s an adventure. My creative and adventurous sides have combined into a real love for science,” he says. Dr. Gormley currently channels his passion for science into his position as an assistant professor of biomedical engineering at Rutgers University in Piscataway, New Jersey.
Lea...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 24, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Computational Biology Medicines Profiles Source Type: blogs
Surface loading of nanoparticles on engineered or natural erythrocytes for prolonged circulation time: strategies and applications
Acta Pharmacol Sin. 2021 Mar 26. doi: 10.1038/s41401-020-00606-z. Online ahead of print.ABSTRACTNano drug-delivery systems (DDS) may significantly improve efficiency and reduce toxicity of loaded drugs, but a few nano-DDS are highly successful in clinical use. Unprotected nanoparticles in blood flow are often quickly cleared, which could limit their circulation time and drug delivery efficiency. Elongating their blood circulation time may improve their delivery efficiency or grant them new therapeutic possibilities. Erythrocytes are abundant endogenous cells in blood and are continuously renewed, with a long life span of 1...
Source: Acta Pharmacologica Sinica - March 27, 2021 Category: Drugs & Pharmacology Authors: Si-Qi Zhang Qiang Fu Yun-Jie Zhang Jian-Xing Pan Ling Zhang Zhi-Rong Zhang Zhen-Mi Liu Source Type: research
Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers
Biomaterials. 2023 Sep 6;302:122318. doi: 10.1016/j.biomaterials.2023.122318. Online ahead of print.ABSTRACTNanoparticle-based drug delivery systems (DDS) have shown promising results in reversing hepatic fibrosis, a common pathological basis of chronic liver diseases (CLDs), in preclinical animal models. However, none of these nanoparticle formulations has transitioned to clinical usage and there are currently no FDA-approved drugs available for liver fibrosis. This highlights the need for a better understanding of the challenges faced by nanoparticles in this complex disease setting. Here, we have systematically studied ...
Source: Biomaterials - September 14, 2023 Category: Materials Science Authors: Arunpandian Balaji Craig A Bell Zachary H Houston Kim R Bridle Berit Genz Nicholas L Fletcher Grant A Ramm Kristofer J Thurecht Source Type: research
Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain
Publication date: Available online 6 October 2018Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Kristen M. Ahlschwede, Geoffry L. Curran, Jens T. Rosenberg, Samuel C. Grant, Gobinda Sarkar, Robert B. Jenkins, Subramanian Ramakrishnan, Joseph F. Poduslo, Karunya K. KandimallaAbstractAccumulation of amyloid beta (Aβ) peptides in the cerebral vasculature, referred to as cerebral amyloid angiopathy (CAA), is widely observed in Alzheimer's disease (AD) brain and was shown to accelerate cognitive decline. There is no effective method for detecting cerebrovascular amyloid (CVA) and treat CAA. The targeted n...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 6, 2018 Category: Nanotechnology Source Type: research
47 Gambogic acid delivery using lipid nanoparticles modified with cell-penetrating peptide
ConclusionsIn conclusion, FA/MA-R7W nanoparticles are promising vehicles for GA delivery and warrant further investigation.AcknowledgmentsThis research was financially supported by Jilin Province Science and Technology Development Program (Grant No. 20140311072YY) and Jilin Province Science and Technology Development Program (Grant No.20150520141JH).
Source: Journal of Investigative Medicine - December 18, 2016 Category: Research Authors: Zhao, M., Li, J., Xiao, L., Zeng, J., Zhang, D., Lee, R. J., Teng, L. Tags: Biochemical Pharmacy Source Type: research
A robust systematic design: Optimization and preparation of polymeric nanoparticles of PLGA for docetaxel intravenous delivery
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Pedram Rafiei, Azita HaddadiAbstractPoly (lactide-co-glycolide) (PLGA) is a biocompatible, biodegradable, and non-toxic polymer used in a variety of biomedical and pharmaceutical applications. Polymeric nanoparticles prepared from PLGA have been extensively used as delivery vehicles of various chemotherapeutic agents. The variability of PLGA polymer and nanoparticle fabrication process potentially results in variability of particle characteristics. Nanoparticle characteristics determine nanoparticles' performance when used as ...
Source: Materials Science and Engineering: C - July 27, 2019 Category: Materials Science Source Type: research
UV Light-Activated GdYVO < sub > 4 < /sub > :Eu < sup > 3+ < /sup > Nanoparticles Induce Reactive Oxygen Species Generation in Leukocytes Without Affecting Erythrocytes In Vitro
Biol Trace Elem Res. 2021 Aug 13. doi: 10.1007/s12011-021-02867-z. Online ahead of print.ABSTRACTNanoparticles (NPs) have been reported to be promising enhancement agents for radiation therapy. The aim of the study was to assess the cytotoxicity of UV non-treated and UV pretreated GdYVO4:Eu3+ nanoparticles against erythrocytes and leukocytes by detecting eryptosis and reactive oxygen species (ROS) generation. Levels of intracellular ROS in erythrocytes and leukocytes using a ROS-sensitive dye 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA), as well as eryptosis rate utilizing annexin V staining, following direct expos...
Source: Biological Trace Element Research - August 13, 2021 Category: Biology Authors: Anatolii Onishchenko Valeriy Myasoedov Svetlana Yefimova Oksana Nakonechna Volodymyr Prokopyuk Dmytro Butov Umut K ökbaş Vladimir Klochkov Pavel Maksimchuk Nataliya Kavok Anton Tkachenko Source Type: research
Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T1-weighted MR imaging.
In this report, monodispersed ultra-small Gd2O3 nanoparticles capped with hydrophobic oleic acid (OA) were synthesized with average particle size of 2.9 nm. Two methods were introduced to modify the surface coating to hydrophilic for bio-applications. With a hydrophilic coating, the polyvinyl pyrrolidone (PVP) coated Gd2O3 nanoparticles (Gd2O3-PVP) showed a reduced longitudinal T1 relaxation time compared with OA and cetyltrimethylammonium bromide (CTAB) co-coated Gd2O3 (Gd2O3-OA-CTAB) in the relaxation study. The Gd2O3-PVP was thus chosen for its further application study in MRI with an improved longitudinal relaxivity r...
Source: Biomaterials - November 26, 2013 Category: Materials Science Authors: Fang J, Chandrasekharan P, Liu XL, Yang Y, Lv YB, Yang CT, Ding J Tags: Biomaterials Source Type: research
Cytotoxic interactions of bare and coated NaGdF4:Yb(3+):Er(3+) nanoparticles with macrophage and fibroblast cells.
Abstract
The lanthanide nano-compounds are well suited to serve as fluorescent and magnetic contrast agents and luminescent labels. Although they are considered as promising materials for bio-imaging and bio-sensors in vivo or in vitro, the amount of data is still insufficient for deep understanding the toxicity of these nanomaterials. This knowledge is of great importance in the light of growing use of the biofunctionalized nanoparticles, which raises some questions about safety of these materials. Despite lanthanide-doped NaGdF4 nanocrystals are considered as non-toxic, here we present the data showing the fatal...
Source: Toxicology in Vitro - November 27, 2015 Category: Toxicology Authors: Wysokińska E, Cichos J, Zioło E, Bednarkiewicz A, Strzadala L, Karbowiak M, Hreniak D, Kalas W Tags: Toxicol In Vitro Source Type: research
Preclinical assessment of nanoparticles conjugated with 64Cu-DOTA-PEG-BBN targeting gastrin-releasing peptide receptors
Conclusions: The combination of size-controlled distribution of nanoparticles, functionalization with high-specific targeting peptides and Cu-64 radioisotope labelling resulted in highly promising imaging/therapeutic scaffolds, based on gold/iron oxide NPs coated with PEG(4) and bearing specific targeting 64Cu-DOTA-BBN analogs. Their preliminary in vitro and in vivo evaluation shows good results regarding uptake, retention, stability and PKs parameters. Further investigations are to be performed to determine the detailed dosimetry and therapeutic efficacy to extend the potential use to targeted radionuclide therapy, by use...
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Chilug, L. E., Nan, A., Leonte, R. A., Dusman, R. D., Abrunhosa, A., Manda, G., Turcu, R., Niculae, D. Tags: Preclinical Probes for Oncology Source Type: research
Abstract 4589: Impact of tumor microenvironment on tumor growth, metastasis and response to combination therapy via microenvironment-responsive dual drug-loaded nanoparticles and radiation
The objective of this study is to establish a novel strategy for radiation therapy-amplified delivery of dual drugs for targeting the microenvironment-responsive endothelial component of the tumor vasculature. Use of radiation-guided anginex bound nanoparticles for delivery and controlled release of dual drugs (Arsenic-cisplatin) are expected to simulate metronomic therapy and preferentially target the tumor endothelial cells at the irradiated tumor site via tumor stroma enriched Galectin-1 protein. Our molecular studies indicate differential vulnerability for arsenic and cisplatin in cell types constituting the tumor/tumo...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Sethi, P., Jyoti, A., Swindell, E., Langner, U. W., Clair, W. H. S., McGarry, R. C., O'Halloran, T. V., Upreti, M. Tags: Experimental and Molecular Therapeutics Source Type: research
Formation of magnetic nanoparticles by low energy dual implantation of Ni and Fe into SiO2
Publication date: 15 May 2016 Source:Journal of Alloys and Compounds, Volume 667 Author(s): Tushara Prakash, Grant V.M. Williams, John Kennedy, Sergey Rubanov Magnetic nanoparticles have been made by Ni and Fe implantation into a SiO2 film with a Ni:Fe ratio of 82:18 both before and after electron beam annealing (EBA). Superparamagnetic nanoparticles with diameters ∼4 nm were observed after implantation. The moment per implanted ion at high magnetic fields was significantly lower than that reported for bulk Ni1−x Fe x with a similar x, which may be due to some implanted ions not magnetically ordering and the app...
Source: Journal of Alloys and Compounds - February 5, 2016 Category: Chemistry Source Type: research
