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Total 25019 results found since Jan 2013.
Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages
In this study, we generated structure-stabilized HA stalk antigens from influenza B and fabricated double-layered protein nanoparticles as universal influenza B vaccine candidates. In vitro studies found that the resulting protein nanoparticles were effectively taken up to activate dendritic cells. Nanoparticle immunization induced broadly reactive immune responses conferring robust and sustained cross-immune protection against influenza B virus strains of both lineages. The results reveal the potential of layered protein nanoparticles incorporated with structure-stabilized constant antigens as a universal influenza vaccin...
Source: Biomaterials - July 10, 2022 Category: Materials Science Authors: Yufeng Song Wandi Zhu Ye Wang Lei Deng Yao Ma Chunhong Dong Gilbert X Gonzalez Joo Kim Lai Wei Sang-Moo Kang Bao-Zhong Wang Source Type: research
T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines
Antiviral Res. 2023 Jul 27:105688. doi: 10.1016/j.antiviral.2023.105688. Online ahead of print.ABSTRACTVaccines that trigger mucosal immune responses at the entry portals of pathogens are highly desired. Here, we showed that antigen-decorated nanoparticle generated through CRISPR engineering of T4 bacteriophage can serve as a universal platform for the rapid development of mucosal vaccines. Insertion of Flu viral M2e into phage T4 genome through fusion to Soc (Small Outer Capsid protein) generated a recombinant phage, and the Soc-M2e proteins self-assembled onto phage capsids to form 3M2e-T4 nanoparticles during propagatio...
Source: Antiviral Research - July 29, 2023 Category: Virology Authors: Mengling Li Cen Chen Xialin Wang Pengju Guo Helong Feng Xueqi Zhang Wanpo Zhang Changqin Gu Jingen Zhu Guoyuan Wen Yaoyu Feng Lihua Xiao Guiqing Peng Venigalla B Rao Pan Tao Source Type: research
Sugarcane ash and sugarcane ash-derived silica nanoparticles alter cellular metabolism in human proximal tubular kidney cells
Environ Pollut. 2023 Jun 8:121951. doi: 10.1016/j.envpol.2023.121951. Online ahead of print.ABSTRACTMultiple epidemics of chronic kidney disease of an unknown etiology (CKDu) have emerged in agricultural communities around the world. Many factors have been posited as potential contributors, but a primary cause has yet to be identified and the disease is considered likely multifactorial. Sugarcane workers are largely impacted by disease leading to the hypothesis that exposure to sugarcane ash produced during the burning and harvest of sugarcane could contribute to CKDu. Estimated exposure levels of particles under 10 μm (P...
Source: Environmental Pollution - June 10, 2023 Category: Environmental Health Authors: Arthur D Stem Keegan L Rogers James R Roede Carlos A Roncal-Jimenez Richard J Johnson Jared M Brown Source Type: research
Self-Assembled Ferritin Nanoparticles Expressing Hemagglutinin as an Influenza Vaccine
NIH inventors at the Vaccine Research Center have developed a novel influenza virus hemagglutinin (HA)-ferritin nanoparticle influenza vaccine that is easily manufactured, potent, and elicits broadly neutralizing influenza antibodies against multiple strains of influenza. This novel influenza nanoparticle vaccine elicited two types of broadly neutralizing, cross-protective antibodies, one directed to the highly conserved HA stem and a second proximal to the conserved receptor binding site (RBS) of the viral HA, providing a new platform for universal and seasonal influenza. In addition, HA-ferritin nanoparticles can be easi...
Source: NIH OTT Licensing Opportunities - July 20, 2012 Category: Research Authors: admin Source Type: research
Airborne magnetic nanoparticles may contribute to COVID-19 outbreak: Relationships in Greece and Iran
Environ Res. 2021 Sep 18;204:112054. doi: 10.1016/j.envres.2021.112054. Online ahead of print.ABSTRACTThis work attempts to shed light on whether the COVID-19 pandemic rides on airborne pollution. In particular, a two-city study provides evidence that PM2.5 contributes to the timing and severity of the epidemic, without adjustment for confounders. The publicly available data of deaths between March and October 2020, updated it on May 30, 2021, and the average seasonal concentrations of PM2.5 pollution over the previous years in Thessaloniki, the second-largest city of Greece, were investigated. It was found that changes in...
Source: Environmental Research - September 21, 2021 Category: Environmental Health Authors: C Martinez-Boubeta K Simeonidis Source Type: research
Nucleic acid extraction without electrical equipment via magnetic nanoparticles in Pasteur pipettes for pathogen detection
Anal Biochem. 2021 Nov 2:114445. doi: 10.1016/j.ab.2021.114445. Online ahead of print.ABSTRACTThe outbreak of COVID-19 makes epidemic prevention and control become a growing global concern. Nucleic acid amplification testing (NAAT) can realize early and rapid detection of targets, thus it is considered as an ideal approach for detecting pathogens of severe acute infectious diseases. Rapid acquisition of high-quality target nucleic acid is the prerequisite to ensure the efficiency and accuracy of NAAT. Herein, we proposed a simple system in which magnetic nanoparticles (MNPs) based nucleic acid extraction was carried out in...
Source: Analytical Biochemistry - November 6, 2021 Category: Biochemistry Authors: Jia Kang Yang Li Yan Zhao Yanling Wang Cuiping Ma Chao Shi Source Type: research
Analysis of Cognition, Protection, Psychological, and Job-search Intentions Among Medical and Nonmedical College Students During COVID-19 Epidemic
CONCLUSIONS: The news about COVID-19 piqued the interest of medical students. Nonmedical students had stronger protective behavior than medical students. The COVID-19 outbreak had a significant influence on medical students' lives, studies, and moods. In addition, COVID-19 had a greater impact on the job-search intentions of medical students.PMID:36525353
Source: Alternative Therapies in Health and Medicine - December 16, 2022 Category: Complementary Medicine Authors: Xuan Long Kai Sun Kai Wang Lishuai Shi Limin Cao Tingting Wen Zhonghua Zhou Zhihua Guo Yue Shi Hong Yu Zhen Yu Xiaolian Song Lijin Feng Aihong Mei Source Type: research
