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Total 20514 results found since Jan 2013.

Multimodal nanoparticles that provide immunomodulation and intracellular drug delivery for infectious diseases
Abstract: Infectious diseases are a worldwide health concern. For some infections, a common feature is the intracellular residence of the pathogen and evasion of the host immune response. In the case of tuberculosis (TB), Mycobacterium tuberculosis evades clearance within macrophages through suppression of intracellular reactive oxygen and nitrogen species (ROS/RNS) and pro-inflammatory cytokines. We propose new nanoparticle designs for infectious diseases, functionalized with ligands able to modulate the cellular immune response and concurrently deliver drug. We have designed 1,3-β-glucan functionalized chitosan shell, p...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - December 11, 2013 Category: Nanotechnology Authors: Admire Dube, Jessica L. Reynolds, Wing-Cheung Law, Charles C. Maponga, Paras N. Prasad, Gene D. Morse Tags: Communicable Diseases, Tuberculosis, Core-Shell Nanoparticles, Glucan-Functionalized Chitosan, Rifampicin Source Type: research

Impact of nanoparticles on amyloid beta-induced Alzheimer's disease, tuberculosis, leprosy and cancer: A systematic review
Biosci Rep. 2023 Jan 11:BSR20220324. doi: 10.1042/BSR20220324. Online ahead of print.ABSTRACTNanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1-100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical f...
Source: Bioscience Reports - January 11, 2023 Category: Biomedical Science Authors: Ayon Chakraborty Saswati Soumya Mohapatra Subhashree Barik Ipsita Roy Bhavika Gupta Ashis Biswas Source Type: research

Effect of polycation coating on the long-term pulsatile release of antigenic ESAT-6 < sub > 1-20 < /sub > peptide from PLGA nanoparticles
Colloids Surf B Biointerfaces. 2023 Jun 20;228:113421. doi: 10.1016/j.colsurfb.2023.113421. Online ahead of print.ABSTRACTThe development of novel vaccine formulations against tuberculosis is necessary to reduce the number of new cases worldwide. Polymeric nanoparticles offer great potential as antigen delivery and immunostimulant systems for such purposes. In the study, we have encapsulated the antigenic peptide epitope of ESAT-6 protein of M. tuberculosis into PLGA nanoparticles and coated these nanoparticles with the cationic polymer of quaternized poly(4-vinylpyridine) (QPVP) to obtain a positively charged system as a ...
Source: Colloids and Surfaces - June 25, 2023 Category: Biotechnology Authors: Hatice K übra Büyükbayraktar Pelin Pelit Aray ıcı Murat Ihlamur Damla G ökkaya Mesut Karahan Emrah Şefik Abamor Murat Topuzo ğulları Source Type: research

Antagonist Impact of Selenium-Based Nanoparticles Against Mycobacterium tuberculosis
This study thus proposes a novel approach and opens new dimensional avenues in the field of nanoparticle-induced cell disruption strategies.PMID:36637700 | DOI:10.1007/s12010-023-04315-1
Source: Applied Biochemistry and Biotechnology - January 13, 2023 Category: Biochemistry Authors: Shagufta Parveen Taniya Sur Soumee Sarkar Rupak Roy Source Type: research

Strategic role of selected noble metal nanoparticles in medicine.
Abstract Noble metals and their compounds have been used as therapeutic agents from the ancient time in medicine for the treatment of various infections. Recently, much progress has been made in the field of nanobiotechnology towards the development of different kinds of nanomaterials with a wide range of applications. Among the metal nanoparticles, noble metal nanoparticles have demonstrated potential biomedical applications. Due to the small size, nanoparticles can easily interact with biomolecules both at surface and inside cells, yielding better signals and target specificity for diagnostics and therapeutics. ...
Source: Critical Reviews in Microbiology - June 19, 2015 Category: Microbiology Authors: Rai M, Ingle AP, Birla S, Yadav A, Santos CA Tags: Crit Rev Microbiol Source Type: research

Limonia acidissima L. leaf mediated synthesis of zinc oxide nanoparticles: A potent tool against Mycobacterium tuberculosis
Conclusion Phytosynthesis of zinc oxide nanoparticles is a green, eco-friendly technology because it is inexpensive and pollution free. In the present investigation, based on our results we conclude that the aqueous extract of leaves of L. acidissima can be used for the synthesis of zinc oxide nanoparticles. These nanoparticles control the growth of M. tuberculosis and this was confirmed with the microplate alamar blue method. The potential of biogenic zinc oxide nanoparticles may be harnessed as a novel medicine ingredient to combat tuberculosis disease.
Source: International Journal of Mycobacteriology - March 30, 2016 Category: Infectious Diseases Source Type: research

Antitubercular activity of ZnO nanoparticles prepared by solution combustion synthesis using lemon juice as bio-fuel.
In this study, we report the synthesis, structural and morphological characteristics of zinc oxide (ZnO) nanoparticles using solution combustion synthesis method where lemon juice was used as the fuel. In vitro anti-tubercular activity of the synthesized ZnO nanoparticles and their biocompatibility studies, both in vitro and in vivo were carried out. The synthesized nanoparticles showed inhibition of Mycobacterium tuberculosis H37Ra strain at concentrations as low as 12.5μg/mL. In vitro cytotoxicity study performed with normal mammalian cells (L929, 3T3-L1) showed that ZnO nanoparticles are non-toxic with a Selectivity In...
Source: Appl Human Sci - April 20, 2017 Category: Physiology Authors: Gopala Krishna P, Paduvarahalli Ananthaswamy P, Trivedi P, Chaturvedi V, Bhangi Mutta N, Sannaiah A, Erra A, Yadavalli T Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Green synthesis of selenium nanoparticles using Rosmarinus officinalis and investigated their antimicrobial activity
Biometals. 2022 Jan 12. doi: 10.1007/s10534-021-00356-3. Online ahead of print.ABSTRACTThe interest of many has been attracted by plant-mediated synthesizing procedures for nanoparticles since they provide certain qualities including being cost-effective, quick, and compatible with the environment. In this regard, this work introduces the production of selenium-nanoparticles (Se-NPs) in a biological manner utilizing aqueous extracts of Rosmarinus officinalis (R. officinalis). Production of Se-NPs was confirmed using UV-visible (UV-Vis) spectrophotometry. Also, dynamic light scattering (DLS) analysis was used for determinat...
Source: Biometals - January 12, 2022 Category: Biochemistry Authors: Fatemeh Adibian Roya Saddat Ghaderi Zahra Sabouri Javid Davoodi Monireh Kazemi Kiarash Ghazvini Masoud Youssefi Saman Soleimanpour Majid Darroudi Source Type: research