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Infectious Disease: Influenza

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Total 16629 results found since Jan 2013.

Virus-Mimicking Cell Membrane-Coated Nanoparticles for Cytosolic Delivery of mRNA
Angew Chem Int Ed Engl. 2021 Oct 25. doi: 10.1002/anie.202113671. Online ahead of print.ABSTRACTEffective endosomal escape after cellular uptake represents a major challenge in the field of nanodelivery, as the majority of drug payloads must localize to subcellular compartments other than the endosomes in order to exert activity. In nature, viruses can readily deliver their genetic material to the cytosol of host cells by triggering membrane fusion after endocytosis. For the influenza A virus, the hemagglutinin (HA) protein found on its surface fuses the viral envelope with surrounding membrane at endosomal pH values. Here...
Source: Angewandte Chemie - October 25, 2021 Category: Chemistry Authors: Joon Ho Park Animesh Mohapatra Jiarong Zhou Maya Holay Nishta Krishnan Weiwei Gao Ronnie H Fang Liangfang Zhang Source Type: research

Validation of Multi-epitope Peptides Encapsulated in PLGA Nanoparticles Against Influenza A Virus
CONCLUSION: The study demonstrated the self-adjuvanting properties of the PLGA nanoparticles as a delivery system without the need for incorporation of toxic and costly conventional adjuvants in multi-epitope peptide-based vaccines.PMID:37344603 | DOI:10.1007/s11095-023-03540-x
Source: Cell Research - June 21, 2023 Category: Cytology Authors: Wen Tzuen Heng Hui Xuan Lim Kuan Onn Tan Chit Laa Poh Source Type: research

Inhibitory effects of silver nanoparticles against adenovirus type 3 in vitro.
Abstract Adenoviruses are associated with respiratory, ocular, or gastrointestinal disease. With various species and high morbidity, adenoviruses are increasingly recognized as significant viral pathogen among pediatric and immunocompromised patients. However, there is almost no specific drug for treatment. Silver nanoparticles are demonstrated to be virucidal against influenza A (H1N1) virus, human immunodeficiency virus and Hepatitis B virus. Currently, there is no data regarding whether the silver nanoparticles inhibit the adenovirus or not. The aim of this study is to investigate the effect of silver nanoparti...
Source: Journal of Virological Methods - July 22, 2013 Category: Virology Authors: Chen N, Zheng Y, Yin J, Li X, Zheng C Tags: J Virol Methods Source Type: research

Pronounced therapeutic potential of oligonucleotides fixed on inorganic nanoparticles against highly pathogenic H5N1 influenza A virus in vivo
This study describes the effective attack of oligonucleotides on the viral genome of highly pathogenic H5N1 influenza A virus (IAV) in vivo using for the first time the new delivery system consisting of biocompatible low-toxic titanium dioxide nanoparticles and immobilized polylysine-containing oligonucleotides with the native (ODN) and partially modified (ODNm) internucleotide bonds. Intraperitoneal injection of the TiO2•PL-ODN nanocomposite provided 65-70% survival of mice, while intraperitoneal or oral administration of TiO2•PL-ODNm was somewhat more efficient (∼80% survival). The virus titer in the lung was reduc...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 23, 2021 Category: Drugs & Pharmacology Authors: Asya Levina Marina Repkova Nadezhda Shikina Zinfer Ismagilov Maxim Kupryushkin Anna Pavlova Natalia Mazurkova Dmitrii Pyshnyi Valentina Zarytova Source Type: research

Inhibitory effects of epigallocatechin gallate (EGCG) combined with zinc sulfate and silver nanoparticles on avian influenza A virus subtype H5N1
CONCLUSIONS: The potentiated antiviral activity of EGCG by co-administering it with zinc II and AgNPs indicates potential as a multi-activity novel topical therapeutic agent against H5N1 flue. This mix makes the adaptation of the virus difficult, which helps to reduce infection resistance.PMID:33829450 | DOI:10.26355/eurrev_202103_25427
Source: Pharmacological Reviews - April 8, 2021 Category: Drugs & Pharmacology Authors: M J Saadh S M Aldalaen Source Type: research

Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages
In this study, we generated structure-stabilized HA stalk antigens from influenza B and fabricated double-layered protein nanoparticles as universal influenza B vaccine candidates. In vitro studies found that the resulting protein nanoparticles were effectively taken up to activate dendritic cells. Nanoparticle immunization induced broadly reactive immune responses conferring robust and sustained cross-immune protection against influenza B virus strains of both lineages. The results reveal the potential of layered protein nanoparticles incorporated with structure-stabilized constant antigens as a universal influenza vaccin...
Source: Biomaterials - July 10, 2022 Category: Materials Science Authors: Yufeng Song Wandi Zhu Ye Wang Lei Deng Yao Ma Chunhong Dong Gilbert X Gonzalez Joo Kim Lai Wei Sang-Moo Kang Bao-Zhong Wang Source Type: research

T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines
Antiviral Res. 2023 Jul 27:105688. doi: 10.1016/j.antiviral.2023.105688. Online ahead of print.ABSTRACTVaccines that trigger mucosal immune responses at the entry portals of pathogens are highly desired. Here, we showed that antigen-decorated nanoparticle generated through CRISPR engineering of T4 bacteriophage can serve as a universal platform for the rapid development of mucosal vaccines. Insertion of Flu viral M2e into phage T4 genome through fusion to Soc (Small Outer Capsid protein) generated a recombinant phage, and the Soc-M2e proteins self-assembled onto phage capsids to form 3M2e-T4 nanoparticles during propagatio...
Source: Antiviral Research - July 29, 2023 Category: Virology Authors: Mengling Li Cen Chen Xialin Wang Pengju Guo Helong Feng Xueqi Zhang Wanpo Zhang Changqin Gu Jingen Zhu Guoyuan Wen Yaoyu Feng Lihua Xiao Guiqing Peng Venigalla B Rao Pan Tao Source Type: research

Induction of innate immunity in lungs with virus-like nanoparticles leads to protection against influenza and Streptococcus pneumoniae challenge
In this study, virus-like nanoparticles were utilized to induce innate immune responses in a mouse model. They were also demonstrated to provide enhanced immune responses during actual pneumonia and ongoing viral infection. Strategies like this may become very helpful in human applications, including bioterrorism countermeasures.Graphical Abstract: Nanoparticles made of the coat protein (CP) of the papaya mosaic virus (PapMV) and a synthetic RNA are able to trigger innate immunity in the lung of animals treated by the intranasal route (I.N.). This stimulation leads to the induction of the antiviral and the anti-bacterial m...
Source: Nanomedicine : Nanotechnology, Biology, and Medicine - March 11, 2013 Category: Nanotechnology Authors: Claudia Mathieu, Gervais Rioux, Marie-Christine Dumas, Denis Leclerc Tags: Communicable Diseases, Immunology, Respiratory System, Influenza, Pneumonia, Papaya Mosaic Virus Source Type: research

Preparation and immunological evaluation of inactivated avian influenza virus vaccine encapsulated in chitosan nanoparticles
Publication date: Available online 8 November 2017 Source:Biologicals Author(s): Samah H. Mohamed, Abdel Satar Arafa, Wesam H. Mady, Hanan A. Fahmy, Lamiaa M. Omer, Rania E. Morsi Efficacy maximization of inactivated avian influenza vaccine using safe adjuvants was investigated. Chitosan nanoparticles were prepared by ionic gelation method with average size of 150 nm and their Zeta potential was 11.5 mV. After encapsulation of avian influenza vaccine, the average size was 397 nm and Zeta potential was 4.29 mV. The highest HI antibody titer results were shown in chicken group vaccinated with inactivated avian influenza...
Source: Biologicals - November 8, 2017 Category: Biology Source Type: research

Preparation and immunological evaluation of inactivated avian influenza virus vaccine encapsulated in chitosan nanoparticles.
Abstract Efficacy maximization of inactivated avian influenza vaccine using safe adjuvants was investigated. Chitosan nanoparticles were prepared by ionic gelation method with average size of 150 nm and their Zeta potential was 11.5 mV. After encapsulation of avian influenza vaccine, the average size was 397 nm and Zeta potential was 4.29 mV. The highest HI antibody titer results were shown in chicken group vaccinated with inactivated avian influenza virus AIV-chitosan followed by the group vaccinated with inactivated AIV-chitosan nanoparticles then the group vaccinated with oil inactivated AIV vaccine, on usi...
Source: Biologicals : Journal of the International Association of Biological Standardization - November 8, 2017 Category: Biotechnology Authors: Mohamed SH, Arafa AS, Mady WH, Fahmy HA, Omer LM, Morsi RE Tags: Biologicals Source Type: research